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Conserved domains on  [gi|767948574|ref|XP_011514818|]
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solute carrier family 13 member 1 isoform X2 [Homo sapiens]

Protein Classification

SLC13 family permease( domain architecture ID 12045581)

SLC13 (solute carrier 13) family permease is a sodium-coupled symporter that facilitates the transport across biological membranes of various ions including sulfate or Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate; may function as a regulator

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
90-594 4.38e-65

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


:

Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 217.71  E-value: 4.38e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  90 IGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQiinaeaeveatq 169
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAA------------ 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 170 mtyfngstnhgleidesvngheinerkektkpvpgynndtgkisskvelekeeeesnqqrvftgswvrkrmklllaytle 249
Cdd:COG0471      --------------------------------------------------------------------------------

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 250 shllnktltfglvipqvkpfqdvplsknsgmrtkYRTKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRY 329
Cdd:COG0471   69 ----------------------------------LGSEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEAT 114

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 330 PdcRCLNFGSWFTFSFPAALIILLLSWIWLQWLFlgfnfkemfkcgKTKTVQQKACAEVIKQEYQKLGPIRYP------G 403
Cdd:COG0471  115 G--IPISFFEWMLVGLPVALVGLLLLWLVLYRLL------------PPEIKEVPGSKEVIREELAELGPLSRRekialaI 180

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 404 FATdsTVALLIGLLFFLIPAktlTKTTPTGEIVAFdYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNK 483
Cdd:COG0471  181 FAL--TVLLWITGSLHGIPI---AVVALLGAVLLL-LTGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADA 254

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 484 LSP-LGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIVF 562
Cdd:COG0471  255 LLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVY 334

                        490       500       510
                 ....*....|....*....|....*....|..
gi 767948574 563 SYGHLKVIDMVKAGLGVNIVGVAVVMLGICTW 594
Cdd:COG0471  335 GSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
CitMHS pfam03600
Citrate transporter;
7-171 1.39e-06

Citrate transporter;


:

Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 50.77  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574    7 ILVYRRFLFVVFTVLVLLPLPIVLHTKEAECAYTLFVVATFWLTEALPLSVTALLPSLMLPMFGIMPSKKVASAYFKDFH 86
Cdd:pfam03600 178 LLIFRKLLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574   87 LLLIGVICLATSIEKWNLHKRIALkmVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQIINAEAEVE 166
Cdd:pfam03600 258 LFFAGLFILVGALEKTGLADALAD--ALGGLSGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPL 335


                  ....*
gi 767948574  167 ATQMT 171
Cdd:pfam03600 336 AWALA 340
 
Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
90-594 4.38e-65

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 217.71  E-value: 4.38e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  90 IGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQiinaeaeveatq 169
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAA------------ 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 170 mtyfngstnhgleidesvngheinerkektkpvpgynndtgkisskvelekeeeesnqqrvftgswvrkrmklllaytle 249
Cdd:COG0471      --------------------------------------------------------------------------------

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 250 shllnktltfglvipqvkpfqdvplsknsgmrtkYRTKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRY 329
Cdd:COG0471   69 ----------------------------------LGSEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEAT 114

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 330 PdcRCLNFGSWFTFSFPAALIILLLSWIWLQWLFlgfnfkemfkcgKTKTVQQKACAEVIKQEYQKLGPIRYP------G 403
Cdd:COG0471  115 G--IPISFFEWMLVGLPVALVGLLLLWLVLYRLL------------PPEIKEVPGSKEVIREELAELGPLSRRekialaI 180

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 404 FATdsTVALLIGLLFFLIPAktlTKTTPTGEIVAFdYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNK 483
Cdd:COG0471  181 FAL--TVLLWITGSLHGIPI---AVVALLGAVLLL-LTGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADA 254

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 484 LSP-LGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIVF 562
Cdd:COG0471  255 LLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVY 334

                        490       500       510
                 ....*....|....*....|....*....|..
gi 767948574 563 SYGHLKVIDMVKAGLGVNIVGVAVVMLGICTW 594
Cdd:COG0471  335 GSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 41-591 2.69e-53

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 186.64  E-value: 2.69e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  41 LFVVATFWLTEALPLSVTALLPSLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNP 120
Cdd:cd01115    4 LVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 121 AWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVqqiinaeaeveatqmtyfngstnhgleidesvngheineRKEKTK 200
Cdd:cd01115   84 RRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLA---------------------------------------AKLDIS 124

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 201 PVpgynndtgkisskvelekeeeesnqqrvftgswvrkrmKLLLaytleshllnktltfglvipqvkpfqdvplsknsgm 280
Cdd:cd01115  125 PS--------------------------------------RLLM------------------------------------ 130

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 281 rtkyrtkkghvtrkltclCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDCrcLNFGSWFTFSFPAALIILLLSWIWLQ 360
Cdd:cd01115  131 ------------------PLAFAASIGGMLTLIGTPPNLVASGYLESLGGQG--FSFFEFTPIGLPLLIIGLLYLWFIFR 190

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 361 WLFLGFNFkemfkcgktktvqqkacaevikqeyqklgpirypgfatdstvaLLIGLLFFLIPAKTLTKTTPTGEIVAFDY 440
Cdd:cd01115  191 LAVLIITI-------------------------------------------VLLAALAAITGLLPVSVAIAIGAIVLVFG 227

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 441 SPLITWKEFQSFmPWDIAILVGGGFALADGCEESGLSKWIGNKLSP-LGSLPAWLIILISSLMVTSLTEVASNPATITLF 519
Cdd:cd01115  228 GVLLTKEDYKSI-DWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLPPFAILLLLCLLTLVLTNFISNTATAVLL 306

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767948574 520 LPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGI 591
Cdd:cd01115  307 APIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSILSLVVSVTMI 378
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 33-599 3.47e-41

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 155.61  E-value: 3.47e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574   33 KEAECAYTLFVVATFWLTEALPLSVTALLP-SLMLPMFGIMPSKK---VASAYFKDFHLLLIGVICLATSIEKWNLHKRI 108
Cdd:pfam00939  29 KAWHLFAIFIATIVGWILEPLPMAVIALFAiSLSAILIGTLLAKAlswALSGFSSTTTWLVFGAFFISAAFEKTGLGRRI 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  109 ALKMVMMVGVNPawLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQIINAeaeveatqmtyfNGSTnhgleidesvn 188
Cdd:pfam00939 109 ALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA------------FGSD----------- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  189 gheinerKEKTKPvpgynndtgkisskvelekeeeesnqqrvftgswvrkrmKLLLAYTLeshllnktltfglvipqvkp 268
Cdd:pfam00939 164 -------PEKGSE---------------------------------------RRIGAYLM-------------------- 177

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  269 fqdvplsknsgmrtkyrtkkghvtrkltcLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDCrcLNFGSWFTFSFPAA 348
Cdd:pfam00939 178 -----------------------------WTVYQSTSITSAMFLTAMAPNLLLLGLMNSILGVT--ITWASWFLAAIPPG 226

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  349 LIILLLSWIWLQWLFLGFNFKemfkcgktktvqQKACAEVIKQEYQKLGPIRypgFATDSTVALLIGLLFFLIPAKTLTK 428
Cdd:pfam00939 227 VILLLLAPLLLYVLYPPEIKS------------VPDAKAIAKTELKELGPMT---FREKALLGLFVLLLLLWIFGGSLNI 291

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  429 TTPTGEIVAFD---YSPLITWKE-FQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPL--GSLPAWLIILISSLM 502
Cdd:pfam00939 292 DATTVAIIGLAlmlLLRILDWKDiVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSlsGFSPAMAFIIILSLF 371

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  503 VTSLTEVASNPATITLFLPILSPLAEAIH-VNPLYILIPSTLCTSFA-FLLPVANPPNAIVFSYGHLKVIDMVKAGLGVN 580
Cdd:pfam00939 372 YLSHYLFASATAHTAAMLPIFAAVAQAIPgAPPLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILT 451

                         570
                  ....*....|....*....
gi 767948574  581 IVGVAVVMLGICTWIVPMF 599
Cdd:pfam00939 452 IIGLLILLLLGNWWWKPLG 470
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 41-594 3.37e-33

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 132.47  E-value: 3.37e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574   41 LFVVATFWLTEALPLSVTALLP----SLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMV 116
Cdd:TIGR00785  17 FVAAIVGWILEPLPLPVTALLAipiiAVLLGVLSAFKFKNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLVGKM 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  117 GVNPAWLTL-GFMSSTAFLSMWLSNTS-TAAMVMPIAEAVVqqiinaeaeveatqmtyfngstnhgleidesvngheine 194
Cdd:TIGR00785  97 GGTTLGLGYfLVFLETLLAPMWPSNTArAGGILLPIIKSLL--------------------------------------- 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  195 rkektkpvPGYNNDTGKISSKVelekeeeesnqqrvftgswvrkrmklllaytleshllnktltfglvipqvkpfqdvpl 274
Cdd:TIGR00785 138 --------PLLGSKPEKSPRKI---------------------------------------------------------- 151

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  275 sknsgmrtkyrtkkghvtRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYfnTRYPDCRCLNFGSWFTFSFPAALIILLL 354
Cdd:TIGR00785 152 ------------------GKYLMLGIAYSASIGSSGFLTGSAPNALAAGI--LSKILGIQISWGDWFLAGLPLGIILLLL 211

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  355 SWIWLQWLFlgfnfkemfkcgKTKTVQQKACAEVIKQEYQKLGPIRYPGFAtdSTVALLIGLLFFLIPAKTLTKTTPTGE 434
Cdd:TIGR00785 212 VPLLLYVLF------------PPELKLKDEVDLWAKEELEEMGPMSFREKA--LLGIFLLALLLWIFGGSLGINASVVAL 277

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  435 IVA--FDYSPLITWKEFQS-FMPWDIAILVGGGFALADGCEESGLSKWIGNKLSP--LGSLPAWLIILISSLMVTSLTEV 509
Cdd:TIGR00785 278 LAVvlMLFLGIVTWKDIQKnKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGilDGLSPTIAVLVLVVLFYIILYFF 357

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  510 ASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFA-FLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVM 588
Cdd:TIGR00785 358 ASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLL 437


                  ....*.
gi 767948574  589 LGICTW 594
Cdd:TIGR00785 438 LVGTLW 443
CitMHS pfam03600
Citrate transporter;
7-171 1.39e-06

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 50.77  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574    7 ILVYRRFLFVVFTVLVLLPLPIVLHTKEAECAYTLFVVATFWLTEALPLSVTALLPSLMLPMFGIMPSKKVASAYFKDFH 86
Cdd:pfam03600 178 LLIFRKLLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574   87 LLLIGVICLATSIEKWNLHKRIALkmVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQIINAEAEVE 166
Cdd:pfam03600 258 LFFAGLFILVGALEKTGLADALAD--ALGGLSGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPL 335


                  ....*
gi 767948574  167 ATQMT 171
Cdd:pfam03600 336 AWALA 340
 
Name Accession Description Interval E-value
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
90-594 4.38e-65

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 217.71  E-value: 4.38e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  90 IGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQiinaeaeveatq 169
Cdd:COG0471    1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAA------------ 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 170 mtyfngstnhgleidesvngheinerkektkpvpgynndtgkisskvelekeeeesnqqrvftgswvrkrmklllaytle 249
Cdd:COG0471      --------------------------------------------------------------------------------

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 250 shllnktltfglvipqvkpfqdvplsknsgmrtkYRTKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRY 329
Cdd:COG0471   69 ----------------------------------LGSEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEAT 114

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 330 PdcRCLNFGSWFTFSFPAALIILLLSWIWLQWLFlgfnfkemfkcgKTKTVQQKACAEVIKQEYQKLGPIRYP------G 403
Cdd:COG0471  115 G--IPISFFEWMLVGLPVALVGLLLLWLVLYRLL------------PPEIKEVPGSKEVIREELAELGPLSRRekialaI 180

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 404 FATdsTVALLIGLLFFLIPAktlTKTTPTGEIVAFdYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNK 483
Cdd:COG0471  181 FAL--TVLLWITGSLHGIPI---AVVALLGAVLLL-LTGVLTWKDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADA 254

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 484 LSP-LGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIVF 562
Cdd:COG0471  255 LLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVY 334

                        490       500       510
                 ....*....|....*....|....*....|..
gi 767948574 563 SYGHLKVIDMVKAGLGVNIVGVAVVMLGICTW 594
Cdd:COG0471  335 GSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 41-591 2.69e-53

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 186.64  E-value: 2.69e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  41 LFVVATFWLTEALPLSVTALLPSLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNP 120
Cdd:cd01115    4 LVFAAVLFVTEALPLDVTALLVPVLLVLLGVVPPKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGE 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 121 AWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVqqiinaeaeveatqmtyfngstnhgleidesvngheineRKEKTK 200
Cdd:cd01115   84 RRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLA---------------------------------------AKLDIS 124

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 201 PVpgynndtgkisskvelekeeeesnqqrvftgswvrkrmKLLLaytleshllnktltfglvipqvkpfqdvplsknsgm 280
Cdd:cd01115  125 PS--------------------------------------RLLM------------------------------------ 130

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 281 rtkyrtkkghvtrkltclCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDCrcLNFGSWFTFSFPAALIILLLSWIWLQ 360
Cdd:cd01115  131 ------------------PLAFAASIGGMLTLIGTPPNLVASGYLESLGGQG--FSFFEFTPIGLPLLIIGLLYLWFIFR 190

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 361 WLFLGFNFkemfkcgktktvqqkacaevikqeyqklgpirypgfatdstvaLLIGLLFFLIPAKTLTKTTPTGEIVAFDY 440
Cdd:cd01115  191 LAVLIITI-------------------------------------------VLLAALAAITGLLPVSVAIAIGAIVLVFG 227

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 441 SPLITWKEFQSFmPWDIAILVGGGFALADGCEESGLSKWIGNKLSP-LGSLPAWLIILISSLMVTSLTEVASNPATITLF 519
Cdd:cd01115  228 GVLLTKEDYKSI-DWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLPPFAILLLLCLLTLVLTNFISNTATAVLL 306

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767948574 520 LPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGI 591
Cdd:cd01115  307 APIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSILSLVVSVTMI 378
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 33-599 3.47e-41

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 155.61  E-value: 3.47e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574   33 KEAECAYTLFVVATFWLTEALPLSVTALLP-SLMLPMFGIMPSKK---VASAYFKDFHLLLIGVICLATSIEKWNLHKRI 108
Cdd:pfam00939  29 KAWHLFAIFIATIVGWILEPLPMAVIALFAiSLSAILIGTLLAKAlswALSGFSSTTTWLVFGAFFISAAFEKTGLGRRI 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  109 ALKMVMMVGVNPawLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQIINAeaeveatqmtyfNGSTnhgleidesvn 188
Cdd:pfam00939 109 ALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIMSLPPA------------FGSD----------- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  189 gheinerKEKTKPvpgynndtgkisskvelekeeeesnqqrvftgswvrkrmKLLLAYTLeshllnktltfglvipqvkp 268
Cdd:pfam00939 164 -------PEKGSE---------------------------------------RRIGAYLM-------------------- 177

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  269 fqdvplsknsgmrtkyrtkkghvtrkltcLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDCrcLNFGSWFTFSFPAA 348
Cdd:pfam00939 178 -----------------------------WTVYQSTSITSAMFLTAMAPNLLLLGLMNSILGVT--ITWASWFLAAIPPG 226

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  349 LIILLLSWIWLQWLFLGFNFKemfkcgktktvqQKACAEVIKQEYQKLGPIRypgFATDSTVALLIGLLFFLIPAKTLTK 428
Cdd:pfam00939 227 VILLLLAPLLLYVLYPPEIKS------------VPDAKAIAKTELKELGPMT---FREKALLGLFVLLLLLWIFGGSLNI 291

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  429 TTPTGEIVAFD---YSPLITWKE-FQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPL--GSLPAWLIILISSLM 502
Cdd:pfam00939 292 DATTVAIIGLAlmlLLRILDWKDiVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSlsGFSPAMAFIIILSLF 371

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  503 VTSLTEVASNPATITLFLPILSPLAEAIH-VNPLYILIPSTLCTSFA-FLLPVANPPNAIVFSYGHLKVIDMVKAGLGVN 580
Cdd:pfam00939 372 YLSHYLFASATAHTAAMLPIFAAVAQAIPgAPPLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILT 451

                         570
                  ....*....|....*....
gi 767948574  581 IVGVAVVMLGICTWIVPMF 599
Cdd:pfam00939 452 IIGLLILLLLGNWWWKPLG 470
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 41-594 3.37e-33

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 132.47  E-value: 3.37e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574   41 LFVVATFWLTEALPLSVTALLP----SLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMV 116
Cdd:TIGR00785  17 FVAAIVGWILEPLPLPVTALLAipiiAVLLGVLSAFKFKNALSGFADPTIWLFFGAFILATALVKTGLGKRIAYKLVGKM 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  117 GVNPAWLTL-GFMSSTAFLSMWLSNTS-TAAMVMPIAEAVVqqiinaeaeveatqmtyfngstnhgleidesvngheine 194
Cdd:TIGR00785  97 GGTTLGLGYfLVFLETLLAPMWPSNTArAGGILLPIIKSLL--------------------------------------- 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  195 rkektkpvPGYNNDTGKISSKVelekeeeesnqqrvftgswvrkrmklllaytleshllnktltfglvipqvkpfqdvpl 274
Cdd:TIGR00785 138 --------PLLGSKPEKSPRKI---------------------------------------------------------- 151

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  275 sknsgmrtkyrtkkghvtRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYfnTRYPDCRCLNFGSWFTFSFPAALIILLL 354
Cdd:TIGR00785 152 ------------------GKYLMLGIAYSASIGSSGFLTGSAPNALAAGI--LSKILGIQISWGDWFLAGLPLGIILLLL 211

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  355 SWIWLQWLFlgfnfkemfkcgKTKTVQQKACAEVIKQEYQKLGPIRYPGFAtdSTVALLIGLLFFLIPAKTLTKTTPTGE 434
Cdd:TIGR00785 212 VPLLLYVLF------------PPELKLKDEVDLWAKEELEEMGPMSFREKA--LLGIFLLALLLWIFGGSLGINASVVAL 277

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  435 IVA--FDYSPLITWKEFQS-FMPWDIAILVGGGFALADGCEESGLSKWIGNKLSP--LGSLPAWLIILISSLMVTSLTEV 509
Cdd:TIGR00785 278 LAVvlMLFLGIVTWKDIQKnKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGilDGLSPTIAVLVLVVLFYIILYFF 357

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  510 ASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFA-FLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVM 588
Cdd:TIGR00785 358 ASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVLL 437


                  ....*.
gi 767948574  589 LGICTW 594
Cdd:TIGR00785 438 LVGTLW 443
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 47-591 4.12e-29

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 119.66  E-value: 4.12e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  47 FWLTEALPLSVTALLPSLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMmVGVNPAWLTLG 126
Cdd:cd00625    3 LIRPEKLPRAVVALLGAVLLVLLGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLAR-ASKGSRRLLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 127 FMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQiinaeaeveatqmtyfngstnhgleidesvngheinerkektkpvpgyn 206
Cdd:cd00625   82 LMLLTAALSAFFSNDATAVLLTPIVLALLRK------------------------------------------------- 112

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 207 ndtgkisskvelekeeeesnqqrvftgswvrkrmklllaytleshllnktltfgLVIPQVKPFqdvplsknsgmrtkyrt 286
Cdd:cd00625  113 ------------------------------------------------------LGLSPPVPL----------------- 121

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 287 kkghvtrkltCLCIAYSSTIGGLTTITGTSTNLIFAEYFNtrypdcrcLNFGSWFTFSFPAALIILLLSWIWLQWLFLGF 366
Cdd:cd00625  122 ----------LLALAFAANIGGAATPIGNPPNLIIASLSG--------LGFLDFLAFMAPPALGLLLLLLGLLYLLFRKK 183

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 367 NFKEmfkcgktKTVQQKACAEVIKQEYQKLGPIRYPGFATDSTVALLIGLLFFLIPAktltktTPTGEIVAFDYSPLITW 446
Cdd:cd00625  184 LLLP-------DEDKLTVLAEPLPARPLLKKFLLLALLLLLLFVLLFFFLIPLGLIA------LLGALLLLLLLVRGLDP 250

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 447 KEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPL 526
Cdd:cd00625  251 EEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLPIAASL 330

                        490       500       510       520       530       540       550
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 527 AEA-----IHVNPLYILIPSTLCTSFAFLLPVANPPNAIVfsygHLKVIDMVKAGLGVNIVGVAVVMLGI 591
Cdd:cd00625  331 APPepawlALALGSTLGGNLTLIGSLANLIPLGAAENAGV----GISFGEFLKVGLPLTLLSLVVSLLYL 396
CitMHS pfam03600
Citrate transporter;
47-539 3.33e-17

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 83.13  E-value: 3.33e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574   47 FWLTEALPLSVTALLPSLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLG 126
Cdd:pfam03600   3 LIITEKLPRDVVALLGAVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  127 FMSSTAFLSMWLSNTSTAAMVMPIAEAVVqqiinaeaeveatqmtyfngstnhgleidesvngheinerkektkpvpgyn 206
Cdd:pfam03600  83 LMLATALLSAFLSNDGTVLIMIPIVLALA--------------------------------------------------- 111

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  207 ndtgkisskvelekeeeesnqqrvftgswvrkrmklllaytleshllnktltfglvipqvkpfqdvplsknsgmrtkyrt 286
Cdd:pfam03600     --------------------------------------------------------------------------------

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  287 KKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNtrypdcrcLNFGSWFTFSFPAALIILLLSWIWLQWLFLGF 366
Cdd:pfam03600 112 RRLGLPPSPLLIALAFAANIGGTATPIGDPPNIIIASALG--------LSFGDFGFFMFPPVGVALLLVGLLPLLLIFRK 183

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  367 NFKEmfkcgktktvqQKACAEVIKQEYQKLGPIRYPGFATDSTVALLIGLLFFLIPAktltkttPTGEIVAFDYSPLITW 446
Cdd:pfam03600 184 LLPV-----------RKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVL-------ALAGALLLLLTGVLDP 245

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  447 KEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGslPAWLIILISSLMVTSLTEVASNPATITLFLPILSPL 526
Cdd:pfam03600 246 EEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGLS--GLLVALALILWLSALLSAFISNVPTAALMAPIIVGM 323

                         490
                  ....*....|...
gi 767948574  527 AEAIHVNPLYILI 539
Cdd:pfam03600 324 APAAGLGDPDPLA 336
CitMHS pfam03600
Citrate transporter;
435-617 4.93e-14

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 73.50  E-value: 4.93e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  435 IVAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPA 514
Cdd:pfam03600  19 AVLLVLLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  515 TITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLL-PVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICT 593
Cdd:pfam03600  99 TVLIMIPIVLALARRLGLPPSPLLIALAFAANIGGTAtPIGDPPNIIIASALGLSFGDFGFFMFPPVGVALLLVGLLPLL 178

                         170       180
                  ....*....|....*....|....
gi 767948574  594 WIVPMFDLYTYPSWAPAMSNETMP 617
Cdd:pfam03600 179 LIFRKLLPVRKEEEAELEELRKRA 202
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 443-601 1.73e-10

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 63.04  E-value: 1.73e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 443 LITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILIsSLMVTSLTEVASNPATITLFLPI 522
Cdd:cd00625   27 VVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARASKGSRRLLLLL-MLLTAALSAFFSNDATAVLLTPI 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 523 LSPLAEAIH-VNPLYILIPSTLCTSFA-FLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMlgICTWIVPMFD 600
Cdd:cd00625  106 VLALLRKLGlSPPVPLLLALAFAANIGgAATPIGNPPNLIIASLSGLGFLDFLAFMAPPALGLLLLLL--GLLYLLFRKK 183


                 .
gi 767948574 601 L 601
Cdd:cd00625  184 L 184
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
443-589 9.15e-08

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 54.75  E-value: 9.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 443 LITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPATITLFLPI 522
Cdd:COG1055   41 VVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPV 120

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767948574 523 LSPLAEAIHVNPLYILIPSTLCTSFA-FLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVML 589
Cdd:COG1055  121 VLAIARRLGLNPVPFLIAIVFAANIGgAATPIGNPTNIMIASAGGLSFLDFLANLFPPSLVSLLVTLL 188
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
463-597 4.37e-07

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 52.46  E-value: 4.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 463 GGFALADGCEESGLSKWIGNK-LSPLGSLPAWLIILIsSLMVTSLTEVASNPATITLFLPILSPLAEAIHVN-----PLY 536
Cdd:COG0471    2 GGFVLAAALEKTGLGRRIALLlLKRFGGSPLRLLLGL-MLATALLSAFISNTARAAMMLPIALSIAAALGSEkrskfGSA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 537 ILIP---STLCTSFAFLlpVANPPNAIVFSY------GHLKVIDMVKAGLGVNIVGVAVVMLgICTWIVP 597
Cdd:COG0471   81 LLLPiafAASIGGMGTL--IGTPPNLIAAGLleeatgIPISFFEWMLVGLPVALVGLLLLWL-VLYRLLP 147
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
40-158 1.26e-06

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 50.92  E-value: 1.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  40 TLFVVATFWLTEA---LPLSVTALLPSLMLPMFGIMPSKKVASAYfkDFHLLLI--GVICLATSIEKWNLHKRIALKMV- 113
Cdd:COG0471  180 IFALTVLLWITGSlhgIPIAVVALLGAVLLLLTGVLTWKDAYKSI--PWGVLLLfgGGLALGAALEKTGLAAWLADALLp 257

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 767948574 114 MMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQI 158
Cdd:COG0471  258 LLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQAL 302
CitMHS pfam03600
Citrate transporter;
7-171 1.39e-06

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 50.77  E-value: 1.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574    7 ILVYRRFLFVVFTVLVLLPLPIVLHTKEAECAYTLFVVATFWLTEALPLSVTALLPSLMLPMFGIMPSKKVASAYFKDFH 86
Cdd:pfam03600 178 LLIFRKLLPVRKEEEAELEELRKRAIKDKLLLAISALVLALVILGFLLLSVLALAGALLLLLTGVLDPEEALKAVDWSTL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574   87 LLLIGVICLATSIEKWNLHKRIALkmVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQIINAEAEVE 166
Cdd:pfam03600 258 LFFAGLFILVGALEKTGLADALAD--ALGGLSGLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAGLGDPDPL 335


                  ....*
gi 767948574  167 ATQMT 171
Cdd:pfam03600 336 AWALA 340
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 440-595 3.30e-04

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 43.39  E-value: 3.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 440 YSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPATITLF 519
Cdd:cd01116   32 ATLSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLM 111

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767948574 520 LPILSPLAEAIHVNPLYILIPSTLCTSF-AFLLPVANPPNAIVFSYGHLKVIDMVkAGLGVNIVGVAVVMLGICTWI 595
Cdd:cd01116  112 VPVTIRLCEVLGLNPVPVLISEVIAANIgGAATLIGDPPNIMIGSAAGLTFNDFL-LHMLPSVVLALVVTFILLYFL 187
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
297-539 8.85e-04

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 42.04  E-value: 8.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 297 CLCIAYSSTIGGLTTITGTSTNLIFAEYFNtrypdcrcLNFGSWFTFSFPAALIILLLSWIWLQWLFLGfnfkemfkcgK 376
Cdd:COG1055  136 LIAIVFAANIGGAATPIGNPTNIMIASAGG--------LSFLDFLANLFPPSLVSLLVTLLVLYLLFRK----------E 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 377 TKTVQQKACAEVIKQEYQKLGPIRYPGFATdsTVALLIGLLFFLIPaktLTKTTPTGEIVAFDYSPLITWKEFQSfMPWD 456
Cdd:COG1055  198 LPAAPDLEDDPKEAIKDRRLLRISLLVLAL--LLVGFVLHSFLGLP---PALIALLGAAVLLLLARVDVREVLKK-VDWS 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 457 IAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLY 536
Cdd:COG1055  272 TLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLGATGNPEPLW 351


                 ...
gi 767948574 537 ILI 539
Cdd:COG1055  352 LAL 354
ArsB_permease cd01118
Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in ...
 455-567 1.07e-03

Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump (ArsAB). The ArsAB complex is similar in many ways to ATP-binding cassette transporters, which have two groups of six transmembrane-spanning helical segments and two nucleotide-binding domains. The ArsB proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life.


Pssm-ID: 238538 [Multi-domain]  Cd Length: 416  Bit Score: 41.87  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574 455 WDIAILVGGGFALADGCEESGLSKWIGNKLSPL----GSLPAWLIILISSLMvtslTEVASNPATITLFLPILSPLAEAI 530
Cdd:cd01118   52 WDVTLTLIGVILLSLLLDEEGFFEWVAALAARWargsGRKLFTLIVLLGAAV----TAFFANDGTALILTPIVIALLRAL 127

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767948574 531 HVNPL----YILIPSTLCTSFAFLLPVANPPNAIVFSYGHL 567
Cdd:cd01118  128 GAKKNrtlpFLYACAFIADAASLPLPISNLVNIVTAGYFGI 168
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
40-157 3.81e-03

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 40.11  E-value: 3.81e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948574  40 TLFVVATFWLteALPLSVTALLPSLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVN 119
Cdd:COG1055   12 TYLLIILEPR--GLNRAVAALLGAALLLLLGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGS 89

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767948574 120 PAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQ 157
Cdd:COG1055   90 PRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARR 127
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
298-364 4.77e-03

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 39.73  E-value: 4.77e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767948574 298 LCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYpdcRCLNFGSWFTFSFPAALIILLLSWIWLQWLFL 364
Cdd:COG1055  352 LALALGATLGGNLTPIGSAANVIVLGIAEKKG---IKISFGEFLKVGLPLTLLTLLIALLYLLLLYF 415
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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