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Conserved domains on  [gi|767948113|ref|XP_011514639|]
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peroxisomal carnitine O-octanoyltransferase isoform X1 [Homo sapiens]

Protein Classification

choline/carnitine O-acyltransferase( domain architecture ID 10466051)

choline/carnitine O-acyltransferase catalyzes the reversible transfer of acyl moieties from acyl-CoA to carnitine or choline

CATH:  3.30.559.70
EC:  2.3.1.-
Gene Ontology:  GO:0016746
PubMed:  29730527
SCOP:  4003020

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Carn_acyltransf pfam00755
Choline/Carnitine o-acyltransferase;
23-573 0e+00

Choline/Carnitine o-acyltransferase;


:

Pssm-ID: 459926  Cd Length: 570  Bit Score: 695.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948113   23 LPVPSLEESLKKYLESVKPFANQEEYKKTEEIVQKFQSGIGEKLHQKLLERAKGKRNWLEEWWLNVAYLDVRIPSQLNVN 102
Cdd:pfam00755   1 LPVPPLEDTLDRYLESVKPLLTEEEYERTEKLVEEFLKGGGPKLQERLLERAKDKKNWLEDWWLDYAYLEYRDPLVLNSN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948113  103 FAGPAAHFEHYWPPKEGTQLERGSITLWHNLNYWQLLRKEKVPVHKVGNTPLDMNQFRMLFSTCKVPGITRDsIMNYFRT 182
Cdd:pfam00755  81 PFFVFPDDPDPLDEPTNTQLKRAANLIYAALKFKRLLDRETLPPDVEGGVPLCMSQYKRLFNTTRIPGKERD-ILQHFPD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948113  183 EseGRSPNHIVVLCRGRAFVFDVIHEGCLVTPPELLRQLTYIHKKCH-SEPDGPGIAALTSEERTRWAKAREYLIGLDPE 261
Cdd:pfam00755 160 S--GVEPRHIVVLRKGQFYKVDVLDSGRPLSPAELEAQLQRILDDASaSNPPPPPVGVLTTDNRDVWAKAREELLKLDPG 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948113  262 NLALLEKIQSSLLVYSMEDSSPHVTPEDYSEIIAAILIGDPTVRWGDKSYNLISFSNGVFGCNCDHAPFDAMIMVNISYY 341
Cdd:pfam00755 238 NAESLEAIESALFVVCLDDASPEDKTELEGSHGGGSLGGDGTNRWFDKSLQLIVFKNGRAGFNGEHSPADGTPVLRLNDY 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948113  342 VDEKIFQNEGRWKGSEKVRDIPlPEELIFIVDEKVLNDINQAKAQYLREASDLQIAAYAFTSFGKKLTKNKMLHPDTFIQ 421
Cdd:pfam00755 318 VLKSIFENKPVSSSSASSLPPP-PEKLEFELDPELKSAIEEAETRFDKLISDLDLRVLEFTDYGKNFIKKFKLSPDAFIQ 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948113  422 LALQLAYYRLHGHPGCCYETAMTRHFYHGRTETMRSCTVEAVRWCQSMQDPSVNLRERQQKMLQAFAKHNKMMKDCSAGK 501
Cdd:pfam00755 397 MALQLAYYRLHGKFAPTYESASTRKFRHGRTETIRSVTPESVAFVKAMLDPSASDEEKRELLRAAVKAHVKLTKEASTGQ 476
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767948113  502 GFDRHLLGLLLIAKEEGLPVPeLFTDPLFSKSgggGNFVLSTSLVGYLRVQGVV-VPMVHNGYGFFYHIRDDR 573
Cdd:pfam00755 477 GVDRHLFGLKLVAKEGGLLPP-LFSDPAYKKS---NHWVLSTSQLGSPALRGGGfGPVVPDGYGIGYNIQDDS 545
 
Name Accession Description Interval E-value
Carn_acyltransf pfam00755
Choline/Carnitine o-acyltransferase;
23-573 0e+00

Choline/Carnitine o-acyltransferase;


Pssm-ID: 459926  Cd Length: 570  Bit Score: 695.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948113   23 LPVPSLEESLKKYLESVKPFANQEEYKKTEEIVQKFQSGIGEKLHQKLLERAKGKRNWLEEWWLNVAYLDVRIPSQLNVN 102
Cdd:pfam00755   1 LPVPPLEDTLDRYLESVKPLLTEEEYERTEKLVEEFLKGGGPKLQERLLERAKDKKNWLEDWWLDYAYLEYRDPLVLNSN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948113  103 FAGPAAHFEHYWPPKEGTQLERGSITLWHNLNYWQLLRKEKVPVHKVGNTPLDMNQFRMLFSTCKVPGITRDsIMNYFRT 182
Cdd:pfam00755  81 PFFVFPDDPDPLDEPTNTQLKRAANLIYAALKFKRLLDRETLPPDVEGGVPLCMSQYKRLFNTTRIPGKERD-ILQHFPD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948113  183 EseGRSPNHIVVLCRGRAFVFDVIHEGCLVTPPELLRQLTYIHKKCH-SEPDGPGIAALTSEERTRWAKAREYLIGLDPE 261
Cdd:pfam00755 160 S--GVEPRHIVVLRKGQFYKVDVLDSGRPLSPAELEAQLQRILDDASaSNPPPPPVGVLTTDNRDVWAKAREELLKLDPG 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948113  262 NLALLEKIQSSLLVYSMEDSSPHVTPEDYSEIIAAILIGDPTVRWGDKSYNLISFSNGVFGCNCDHAPFDAMIMVNISYY 341
Cdd:pfam00755 238 NAESLEAIESALFVVCLDDASPEDKTELEGSHGGGSLGGDGTNRWFDKSLQLIVFKNGRAGFNGEHSPADGTPVLRLNDY 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948113  342 VDEKIFQNEGRWKGSEKVRDIPlPEELIFIVDEKVLNDINQAKAQYLREASDLQIAAYAFTSFGKKLTKNKMLHPDTFIQ 421
Cdd:pfam00755 318 VLKSIFENKPVSSSSASSLPPP-PEKLEFELDPELKSAIEEAETRFDKLISDLDLRVLEFTDYGKNFIKKFKLSPDAFIQ 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948113  422 LALQLAYYRLHGHPGCCYETAMTRHFYHGRTETMRSCTVEAVRWCQSMQDPSVNLRERQQKMLQAFAKHNKMMKDCSAGK 501
Cdd:pfam00755 397 MALQLAYYRLHGKFAPTYESASTRKFRHGRTETIRSVTPESVAFVKAMLDPSASDEEKRELLRAAVKAHVKLTKEASTGQ 476
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767948113  502 GFDRHLLGLLLIAKEEGLPVPeLFTDPLFSKSgggGNFVLSTSLVGYLRVQGVV-VPMVHNGYGFFYHIRDDR 573
Cdd:pfam00755 477 GVDRHLFGLKLVAKEGGLLPP-LFSDPAYKKS---NHWVLSTSQLGSPALRGGGfGPVVPDGYGIGYNIQDDS 545
 
Name Accession Description Interval E-value
Carn_acyltransf pfam00755
Choline/Carnitine o-acyltransferase;
23-573 0e+00

Choline/Carnitine o-acyltransferase;


Pssm-ID: 459926  Cd Length: 570  Bit Score: 695.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948113   23 LPVPSLEESLKKYLESVKPFANQEEYKKTEEIVQKFQSGIGEKLHQKLLERAKGKRNWLEEWWLNVAYLDVRIPSQLNVN 102
Cdd:pfam00755   1 LPVPPLEDTLDRYLESVKPLLTEEEYERTEKLVEEFLKGGGPKLQERLLERAKDKKNWLEDWWLDYAYLEYRDPLVLNSN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948113  103 FAGPAAHFEHYWPPKEGTQLERGSITLWHNLNYWQLLRKEKVPVHKVGNTPLDMNQFRMLFSTCKVPGITRDsIMNYFRT 182
Cdd:pfam00755  81 PFFVFPDDPDPLDEPTNTQLKRAANLIYAALKFKRLLDRETLPPDVEGGVPLCMSQYKRLFNTTRIPGKERD-ILQHFPD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948113  183 EseGRSPNHIVVLCRGRAFVFDVIHEGCLVTPPELLRQLTYIHKKCH-SEPDGPGIAALTSEERTRWAKAREYLIGLDPE 261
Cdd:pfam00755 160 S--GVEPRHIVVLRKGQFYKVDVLDSGRPLSPAELEAQLQRILDDASaSNPPPPPVGVLTTDNRDVWAKAREELLKLDPG 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948113  262 NLALLEKIQSSLLVYSMEDSSPHVTPEDYSEIIAAILIGDPTVRWGDKSYNLISFSNGVFGCNCDHAPFDAMIMVNISYY 341
Cdd:pfam00755 238 NAESLEAIESALFVVCLDDASPEDKTELEGSHGGGSLGGDGTNRWFDKSLQLIVFKNGRAGFNGEHSPADGTPVLRLNDY 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948113  342 VDEKIFQNEGRWKGSEKVRDIPlPEELIFIVDEKVLNDINQAKAQYLREASDLQIAAYAFTSFGKKLTKNKMLHPDTFIQ 421
Cdd:pfam00755 318 VLKSIFENKPVSSSSASSLPPP-PEKLEFELDPELKSAIEEAETRFDKLISDLDLRVLEFTDYGKNFIKKFKLSPDAFIQ 396
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767948113  422 LALQLAYYRLHGHPGCCYETAMTRHFYHGRTETMRSCTVEAVRWCQSMQDPSVNLRERQQKMLQAFAKHNKMMKDCSAGK 501
Cdd:pfam00755 397 MALQLAYYRLHGKFAPTYESASTRKFRHGRTETIRSVTPESVAFVKAMLDPSASDEEKRELLRAAVKAHVKLTKEASTGQ 476
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767948113  502 GFDRHLLGLLLIAKEEGLPVPeLFTDPLFSKSgggGNFVLSTSLVGYLRVQGVV-VPMVHNGYGFFYHIRDDR 573
Cdd:pfam00755 477 GVDRHLFGLKLVAKEGGLLPP-LFSDPAYKKS---NHWVLSTSQLGSPALRGGGfGPVVPDGYGIGYNIQDDS 545
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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