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Conserved domains on  [gi|767947671|ref|XP_011514454|]
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WD repeat-containing protein 86 isoform X10 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-241 2.57e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 183.69  E-value: 2.57e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL--EDEAAFTCSADCTIRR 81
Cdd:cd00200   40 TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFspDGRILSSSSRDKTIKV 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671  82 WDVLTGQCLQVYRGHTSIVN--RILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPwdlpstpcaee 159
Cdd:cd00200  120 WDVETGKCLTTLRGHTDWVNsvAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD----------- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671 160 aaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 239
Cdd:cd00200  189 ---GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVT 265


                 ..
gi 767947671 240 CL 241
Cdd:cd00200  266 SL 267
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-241 2.57e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 183.69  E-value: 2.57e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL--EDEAAFTCSADCTIRR 81
Cdd:cd00200   40 TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFspDGRILSSSSRDKTIKV 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671  82 WDVLTGQCLQVYRGHTSIVN--RILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPwdlpstpcaee 159
Cdd:cd00200  120 WDVETGKCLTTLRGHTDWVNsvAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD----------- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671 160 aaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 239
Cdd:cd00200  189 ---GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVT 265


                 ..
gi 767947671 240 CL 241
Cdd:cd00200  266 SL 267
WD40 COG2319
WD40 repeat [General function prediction only];
4-241 1.66e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.11  E-value: 1.66e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTfcqledEAAF--------TCSA 75
Cdd:COG2319  109 TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVT------SVAFspdgkllaSGSD 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671  76 DCTIRRWDVLTGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSaP----- 148
Cdd:COG2319  183 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS-Pdgrll 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671 149 -----------WDLPSTPCAEEAAA-------------GGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTP 204
Cdd:COG2319  262 asgsadgtvrlWDLATGELLRTLTGhsggvnsvafspdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 341

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 767947671 205 GHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICL 241
Cdd:COG2319  342 GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV 378
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 108-222 4.79e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.24  E-value: 4.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671 108 NQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSapwdlpstpcaeeAAAGGLLVTGSTDGTAKVWQVASGCCHQ 187
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYS-------------SADPTLLASGSDDGSVKLWSINQGVSIG 612

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767947671 188 TLRghTGAVLCLVL---DTPGHTAFtGSTDATIRAWDI 222
Cdd:PLN00181 613 TIK--TKANICCVQfpsESGRSLAF-GSADHKVYYYDL 647
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 5-43 5.91e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 5.91e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767947671     5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
5-43 3.63e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 3.63e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767947671    5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-241 2.57e-56

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 183.69  E-value: 2.57e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL--EDEAAFTCSADCTIRR 81
Cdd:cd00200   40 TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFspDGRILSSSSRDKTIKV 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671  82 WDVLTGQCLQVYRGHTSIVN--RILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPwdlpstpcaee 159
Cdd:cd00200  120 WDVETGKCLTTLRGHTDWVNsvAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD----------- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671 160 aaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 239
Cdd:cd00200  189 ---GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVT 265


                 ..
gi 767947671 240 CL 241
Cdd:cd00200  266 SL 267
WD40 COG2319
WD40 repeat [General function prediction only];
4-241 1.66e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.11  E-value: 1.66e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTfcqledEAAF--------TCSA 75
Cdd:COG2319  109 TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVT------SVAFspdgkllaSGSD 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671  76 DCTIRRWDVLTGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSaP----- 148
Cdd:COG2319  183 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS-Pdgrll 261

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671 149 -----------WDLPSTPCAEEAAA-------------GGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTP 204
Cdd:COG2319  262 asgsadgtvrlWDLATGELLRTLTGhsggvnsvafspdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD 341

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 767947671 205 GHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICL 241
Cdd:COG2319  342 GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV 378
WD40 COG2319
WD40 repeat [General function prediction only];
5-222 7.92e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.79  E-value: 7.92e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671   5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFcqledeAAF--------TCSAD 76
Cdd:COG2319  194 GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRS------VAFspdgrllaSGSAD 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671  77 CTIRRWDVLTGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSApwdlpst 154
Cdd:COG2319  268 GTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP------- 340

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767947671 155 pcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDI 222
Cdd:COG2319  341 -------DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
3-241 2.74e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 168.94  E-value: 2.74e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671   3 GGGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTfcqledEAAF--------TCS 74
Cdd:COG2319   66 AAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVR------SVAFspdgktlaSGS 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671  75 ADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANN--QLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAP---- 148
Cdd:COG2319  140 ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkll 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671 149 -----------WDLPSTPCAEE---------AAA----GGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTP 204
Cdd:COG2319  220 asgsadgtvrlWDLATGKLLRTltghsgsvrSVAfspdGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPD 299

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 767947671 205 GHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICL 241
Cdd:COG2319  300 GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336
WD40 COG2319
WD40 repeat [General function prediction only];
4-241 9.67e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 148.91  E-value: 9.67e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL--EDEAAFTCSADCTIRR 81
Cdd:COG2319   25 LGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFspDGRLLASASADGTVRL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671  82 WDVLTGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSApwdlpstpcaee 159
Cdd:COG2319  105 WDLATGLLLRTLTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP------------ 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671 160 aaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 239
Cdd:COG2319  173 --DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR 250


                 ..
gi 767947671 240 CL 241
Cdd:COG2319  251 SV 252
WD40 COG2319
WD40 repeat [General function prediction only];
4-182 4.87e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.19  E-value: 4.87e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFcqledeAAF--------TCSA 75
Cdd:COG2319  235 TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNS------VAFspdgkllaSGSD 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671  76 DCTIRRWDVLTGQCLQVYRGHTSIVNRILVANN--QLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSApwdlps 153
Cdd:COG2319  309 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP------ 382

                        170       180
                 ....*....|....*....|....*....
gi 767947671 154 tpcaeeaaAGGLLVTGSTDGTAKVWQVAS 182
Cdd:COG2319  383 --------DGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
22-241 2.60e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.79  E-value: 2.60e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671  22 SLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVT--FCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSI 99
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVAslAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671 100 VNRILVA--NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKV 177
Cdd:COG2319   81 VLSVAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP--------------DGKTLASGSADGTVRL 146

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767947671 178 WQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICL 241
Cdd:COG2319  147 WDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 210
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 89-241 1.25e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.97  E-value: 1.25e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671  89 CLQVYRGHTSIVNRILVANNQ--LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLL 166
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGklLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA--------------DGTYL 66

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767947671 167 VTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICL 241
Cdd:cd00200   67 ASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSV 141
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 108-222 4.79e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.24  E-value: 4.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671 108 NQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSapwdlpstpcaeeAAAGGLLVTGSTDGTAKVWQVASGCCHQ 187
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYS-------------SADPTLLASGSDDGSVKLWSINQGVSIG 612

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767947671 188 TLRghTGAVLCLVL---DTPGHTAFtGSTDATIRAWDI 222
Cdd:PLN00181 613 TIK--TKANICCVQfpsESGRSLAF-GSADHKVYYYDL 647
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 5-43 5.91e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 5.91e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767947671     5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
5-43 3.63e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 3.63e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767947671    5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 182-221 3.79e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 3.79e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767947671   182 SGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 221
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 5-222 7.41e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.20  E-value: 7.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671   5 GSALRVCADHRGGINWLSLSpdgqrlltgsedGTARLWSTADGQCCA---LLQGHESY---VTFCQLEDEAAFTCSADCT 78
Cdd:PTZ00421  32 CSNTIACNDRFIAVPWQQLG------------STAVLKHTDYGKLASnppILLGQEGPiidVAFNPFDPQKLFTASEDGT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671  79 IRRWDV----LTGQC------LQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAysap 148
Cdd:PTZ00421 100 IMGWGIpeegLTQNIsdpivhLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLE---- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947671 149 WDLpstpcaeeaaAGGLLVTGSTDGTAKVWQ------VASGCCHQTLRGHTgAVLCLVLDTPGHTAFTGSTDATIRAWDI 222
Cdd:PTZ00421 176 WNL----------DGSLLCTTSKDKKLNIIDprdgtiVSSVEAHASAKSQR-CLWAKRKDLIITLGCSKSQQRQIMLWDT 244
WD40 pfam00400
WD domain, G-beta repeat;
183-221 1.37e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 1.37e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767947671  183 GCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 221
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 86-123 1.11e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.11e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767947671    86 TGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWS 123
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
87-123 7.63e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 7.63e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767947671   87 GQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWS 123
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSpdGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 126-178 6.37e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 6.37e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 767947671   126 KGQMSREFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVW 178
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP--------------DGKYLASGSDDGTIKLW 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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