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Conserved domains on  [gi|767947657|ref|XP_011514448|]
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WD repeat-containing protein 86 isoform X4 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-344 3.99e-76

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 240.58  E-value: 3.99e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657   3 GGGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTfcqledEAAF--------TCS 74
Cdd:COG2319   66 AAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVR------SVAFspdgktlaSGS 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657  75 ADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANN--QLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSapwdlp 152
Cdd:COG2319  140 ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS------ 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 153 stpcaeeaAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFR 232
Cdd:COG2319  214 --------PDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 233 EHRGSVICLELV--NRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA--GTLFTGSGDACARAFDAQSGELR 308
Cdd:COG2319  286 GHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgKTLASGSDDGTVRLWDLATGELL 365

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 767947657 309 RVFRGHTFIINCIQVH--GQVLYTASHDGALRLWDVRG 344
Cdd:COG2319  366 RTLTGHTGAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-344 3.99e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 240.58  E-value: 3.99e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657   3 GGGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTfcqledEAAF--------TCS 74
Cdd:COG2319   66 AAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVR------SVAFspdgktlaSGS 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657  75 ADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANN--QLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSapwdlp 152
Cdd:COG2319  140 ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS------ 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 153 stpcaeeaAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFR 232
Cdd:COG2319  214 --------PDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 233 EHRGSVICLELV--NRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA--GTLFTGSGDACARAFDAQSGELR 308
Cdd:COG2319  286 GHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgKTLASGSDDGTVRLWDLATGELL 365

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 767947657 309 RVFRGHTFIINCIQVH--GQVLYTASHDGALRLWDVRG 344
Cdd:COG2319  366 RTLTGHTGAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 53-341 2.26e-65

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 209.11  E-value: 2.26e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657  53 LQGHESYVTFCQLEDEAAF--TCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILV--ANNQLFSSSYDRTARVWSVDKGQ 128
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLlaTGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 129 MSREFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTA 208
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSP--------------DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 209 FTGSTDATIRAWDILSGEQLRVFREHRGSV--ICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAG 286
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATLTGHTGEVnsVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD 230

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767947657 287 T--LFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH--GQVLYTASHDGALRLWD 341
Cdd:cd00200  231 GylLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSpdGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 108-292 1.55e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 59.72  E-value: 1.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 108 NQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSapwdlpstpcaeeAAAGGLLVTGSTDGTAKVWQVASGCCHQ 187
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYS-------------SADPTLLASGSDDGSVKLWSINQGVSIG 612

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 188 TLRghTGAVLCLVL---DTPGHTAFtGSTDATIRAWDILSGE-QLRVFREHRGSVICLELVN-RLVYSGSADRTVKCW-- 260
Cdd:PLN00181 613 TIK--TKANICCVQfpsESGRSLAF-GSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDsSTLVSSSTDNTLKLWdl 689

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 767947657 261 -LADTG---ECVRTFTAHR--RNVSALKYHAGTLFTGS 292
Cdd:PLN00181 690 sMSISGineTPLHSFMGHTnvKNFVGLSVSDGYIATGS 727
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 5-43 1.03e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.03e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767947657     5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
5-43 5.84e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 5.84e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767947657    5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-344 3.99e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 240.58  E-value: 3.99e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657   3 GGGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTfcqledEAAF--------TCS 74
Cdd:COG2319   66 AAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVR------SVAFspdgktlaSGS 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657  75 ADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANN--QLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSapwdlp 152
Cdd:COG2319  140 ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS------ 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 153 stpcaeeaAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFR 232
Cdd:COG2319  214 --------PDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 233 EHRGSVICLELV--NRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA--GTLFTGSGDACARAFDAQSGELR 308
Cdd:COG2319  286 GHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgKTLASGSDDGTVRLWDLATGELL 365

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 767947657 309 RVFRGHTFIINCIQVH--GQVLYTASHDGALRLWDVRG 344
Cdd:COG2319  366 RTLTGHTGAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
4-346 7.31e-68

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 219.40  E-value: 7.31e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL--EDEAAFTCSADCTIRR 81
Cdd:COG2319   25 LGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFspDGRLLASASADGTVRL 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657  82 WDVLTGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSApwdlpstpcaee 159
Cdd:COG2319  105 WDLATGLLLRTLTGHTGAVRSVAFSpdGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP------------ 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 160 aaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 239
Cdd:COG2319  173 --DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 240 CLELV--NRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAG--TLFTGSGDACARAFDAQSGELRRVFRGHT 315
Cdd:COG2319  251 SVAFSpdGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHT 330

                        330       340       350
                 ....*....|....*....|....*....|...
gi 767947657 316 FIINCIQVH--GQVLYTASHDGALRLWDVRGLR 346
Cdd:COG2319  331 GAVRSVAFSpdGKTLASGSDDGTVRLWDLATGE 363
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 53-341 2.26e-65

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 209.11  E-value: 2.26e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657  53 LQGHESYVTFCQLEDEAAF--TCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILV--ANNQLFSSSYDRTARVWSVDKGQ 128
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLlaTGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 129 MSREFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTA 208
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSP--------------DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 209 FTGSTDATIRAWDILSGEQLRVFREHRGSV--ICLELVNRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHAG 286
Cdd:cd00200  151 ASSSQDGTIKLWDLRTGKCVATLTGHTGEVnsVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD 230

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767947657 287 T--LFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH--GQVLYTASHDGALRLWD 341
Cdd:cd00200  231 GylLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSpdGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-260 1.11e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 191.78  E-value: 1.11e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657   4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQL--EDEAAFTCSADCTIRR 81
Cdd:cd00200   40 TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFspDGRILSSSSRDKTIKV 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657  82 WDVLTGQCLQVYRGHTSIVN--RILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSAPwdlpstpcaee 159
Cdd:cd00200  120 WDVETGKCLTTLRGHTDWVNsvAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD----------- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 160 aaaGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVI 239
Cdd:cd00200  189 ---GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVT 265

                        250       260
                 ....*....|....*....|...
gi 767947657 240 CLELVN--RLVYSGSADRTVKCW 260
Cdd:cd00200  266 SLAWSPdgKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 89-343 5.21e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 187.54  E-value: 5.21e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657  89 CLQVYRGHTSIVNRILVANNQ--LFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLL 166
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGklLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA--------------DGTYL 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 167 VTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLEL--V 244
Cdd:cd00200   67 ASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspD 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 245 NRLVYSGSADRTVKCWLADTGECVRTFTAHRRNVSALKYHA--GTLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQ 322
Cdd:cd00200  147 GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVA 226

                        250       260
                 ....*....|....*....|...
gi 767947657 323 VH--GQVLYTASHDGALRLWDVR 343
Cdd:cd00200  227 FSpdGYLLASGSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
22-346 6.35e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 190.89  E-value: 6.35e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657  22 SLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVT--FCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSI 99
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVAslAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 100 VNRILVA--NNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSApwdlpstpcaeeaaAGGLLVTGSTDGTAKV 177
Cdd:COG2319   81 VLSVAFSpdGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP--------------DGKTLASGSADGTVRL 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 178 WQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELV--NRLVYSGSADR 255
Cdd:COG2319  147 WDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLASGSADG 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 256 TVKCWLADTGECVRTFTAHRRNVSALKYHAG--TLFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH--GQVLYTA 331
Cdd:COG2319  227 TVRLWDLATGKLLRTLTGHSGSVRSVAFSPDgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKLLASG 306

                        330
                 ....*....|....*
gi 767947657 332 SHDGALRLWDVRGLR 346
Cdd:COG2319  307 SDDGTVRLWDLATGK 321
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 185-346 2.85e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.84  E-value: 2.85e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 185 CHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELV--NRLVYSGSADRTVKCWLA 262
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASadGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 263 DTGECVRTFTAHRRNVSALKYHAGT--LFTGSGDACARAFDAQSGELRRVFRGHTFIINCIQVH--GQVLYTASHDGALR 338
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGriLSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSpdGTFVASSSQDGTIK 160


                 ....*...
gi 767947657 339 LWDVRGLR 346
Cdd:cd00200  161 LWDLRTGK 168
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 108-292 1.55e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 59.72  E-value: 1.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 108 NQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAYSapwdlpstpcaeeAAAGGLLVTGSTDGTAKVWQVASGCCHQ 187
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYS-------------SADPTLLASGSDDGSVKLWSINQGVSIG 612

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 188 TLRghTGAVLCLVL---DTPGHTAFtGSTDATIRAWDILSGE-QLRVFREHRGSVICLELVN-RLVYSGSADRTVKCW-- 260
Cdd:PLN00181 613 TIK--TKANICCVQfpsESGRSLAF-GSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDsSTLVSSSTDNTLKLWdl 689

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 767947657 261 -LADTG---ECVRTFTAHR--RNVSALKYHAGTLFTGS 292
Cdd:PLN00181 690 sMSISGineTPLHSFMGHTnvKNFVGLSVSDGYIATGS 727
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 5-43 1.03e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.03e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767947657     5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 5-267 2.04e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 2.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657   5 GSALRVCADHRGGINWLSLSpdgqrlltgsedGTARLWSTADGQCCA---LLQGHESY---VTFCQLEDEAAFTCSADCT 78
Cdd:PTZ00421  32 CSNTIACNDRFIAVPWQQLG------------STAVLKHTDYGKLASnppILLGQEGPiidVAFNPFDPQKLFTASEDGT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657  79 IRRWDV----LTGQC------LQVYRGHTSIVNRILVANNQLFSSSYDRTARVWSVDKGQMSREFRGHRNCVLTLAysap 148
Cdd:PTZ00421 100 IMGWGIpeegLTQNIsdpivhLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLE---- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 149 WDLpstpcaeeaaAGGLLVTGSTDGTAKVWQ------VASGCCHQTLRGHTgAVLCLVLDTPGHTAFTGSTDATIRAWDI 222
Cdd:PTZ00421 176 WNL----------DGSLLCTTSKDKKLNIIDprdgtiVSSVEAHASAKSQR-CLWAKRKDLIITLGCSKSQQRQIMLWDT 244

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767947657 223 --------------LSGEQLRVFREH----------RGSVICLELVN-RLVYSGSADRT--------VKCWLADTGEC 267
Cdd:PTZ00421 245 rkmaspystvdldqSSALFIPFFDEDtnllyigskgEGNIRCFELMNeRLTFCSSYSSVephkglcmMPKWSLDTRKC 322
WD40 pfam00400
WD domain, G-beta repeat;
5-43 5.84e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 5.84e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767947657    5 GSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 182-221 6.67e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 6.67e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767947657   182 SGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 221
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 304-341 9.78e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 9.78e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767947657   304 SGELRRVFRGHTFIINCIQVH--GQVLYTASHDGALRLWD 341
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
183-221 2.22e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.22e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767947657  183 GCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATIRAWD 221
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 214-342 3.26e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.85  E-value: 3.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947657 214 DATIRAWDILSGEQLRVFREHRGSVICLELVN---RLVYSGSADRTVKCWLADTGECVRTFTAhRRNVSALKYHAGT--- 287
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSadpTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSESgrs 632

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767947657 288 LFTGSGDACARAFDAQSGELRR-VFRGHTFIINCIQ-VHGQVLYTASHDGALRLWDV 342
Cdd:PLN00181 633 LAFGSADHKVYYYDLRNPKLPLcTMIGHSKTVSYVRfVDSSTLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
305-341 7.22e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 7.22e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767947657  305 GELRRVFRGHTFIINCIQVH--GQVLYTASHDGALRLWD 341
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSpdGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 86-123 2.02e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 2.02e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767947657    86 TGQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWS 123
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
87-123 1.25e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.25e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 767947657   87 GQCLQVYRGHTSIVNRILVA--NNQLFSSSYDRTARVWS 123
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSpdGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 224-260 1.37e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.37e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 767947657   224 SGEQLRVFREHRGSVICLELV--NRLVYSGSADRTVKCW 260
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
225-260 3.81e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 3.81e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767947657  225 GEQLRVFREHRGSVICLELV--NRLVYSGSADRTVKCW 260
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSpdGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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