serine/threonine-protein phosphatase 1 regulatory subunit 10 isoform X1 [Homo sapiens]
List of domain hits
Name | Accession | Description | Interval | E-value | ||
TFIIS_I super family | cl00146 | N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a ... |
102-146 | 2.31e-10 | ||
N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme The actual alignment was detected with superfamily member smart00509: Pssm-ID: 469629 [Multi-domain] Cd Length: 75 Bit Score: 57.32 E-value: 2.31e-10
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zf-CCCH | pfam00642 | Zinc finger C-x8-C-x5-C-x3-H type (and similar); |
909-932 | 1.49e-04 | ||
Zinc finger C-x8-C-x5-C-x3-H type (and similar); : Pssm-ID: 459885 [Multi-domain] Cd Length: 27 Bit Score: 39.48 E-value: 1.49e-04
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Name | Accession | Description | Interval | E-value | ||
TFS2N | smart00509 | Domain in the N-terminus of transcription elongation factor S-II (and elsewhere); |
102-146 | 2.31e-10 | ||
Domain in the N-terminus of transcription elongation factor S-II (and elsewhere); Pssm-ID: 197766 [Multi-domain] Cd Length: 75 Bit Score: 57.32 E-value: 2.31e-10
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Med26 | pfam08711 | TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is ... |
102-144 | 1.29e-09 | ||
TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5. Pssm-ID: 462573 [Multi-domain] Cd Length: 52 Bit Score: 54.44 E-value: 1.29e-09
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TFIIS_I | cd00183 | N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a ... |
102-145 | 1.46e-09 | ||
N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme Pssm-ID: 238107 Cd Length: 76 Bit Score: 55.01 E-value: 1.46e-09
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zf-CCCH | pfam00642 | Zinc finger C-x8-C-x5-C-x3-H type (and similar); |
909-932 | 1.49e-04 | ||
Zinc finger C-x8-C-x5-C-x3-H type (and similar); Pssm-ID: 459885 [Multi-domain] Cd Length: 27 Bit Score: 39.48 E-value: 1.49e-04
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ZnF_C3H1 | smart00356 | zinc finger; |
910-932 | 2.56e-04 | ||
zinc finger; Pssm-ID: 214632 [Multi-domain] Cd Length: 27 Bit Score: 38.76 E-value: 2.56e-04
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Name | Accession | Description | Interval | E-value | ||
TFS2N | smart00509 | Domain in the N-terminus of transcription elongation factor S-II (and elsewhere); |
102-146 | 2.31e-10 | ||
Domain in the N-terminus of transcription elongation factor S-II (and elsewhere); Pssm-ID: 197766 [Multi-domain] Cd Length: 75 Bit Score: 57.32 E-value: 2.31e-10
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Med26 | pfam08711 | TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is ... |
102-144 | 1.29e-09 | ||
TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5. Pssm-ID: 462573 [Multi-domain] Cd Length: 52 Bit Score: 54.44 E-value: 1.29e-09
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TFIIS_I | cd00183 | N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a ... |
102-145 | 1.46e-09 | ||
N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme Pssm-ID: 238107 Cd Length: 76 Bit Score: 55.01 E-value: 1.46e-09
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zf-CCCH | pfam00642 | Zinc finger C-x8-C-x5-C-x3-H type (and similar); |
909-932 | 1.49e-04 | ||
Zinc finger C-x8-C-x5-C-x3-H type (and similar); Pssm-ID: 459885 [Multi-domain] Cd Length: 27 Bit Score: 39.48 E-value: 1.49e-04
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ZnF_C3H1 | smart00356 | zinc finger; |
910-932 | 2.56e-04 | ||
zinc finger; Pssm-ID: 214632 [Multi-domain] Cd Length: 27 Bit Score: 38.76 E-value: 2.56e-04
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zf-CCCH_4 | pfam18044 | CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ... |
910-932 | 4.91e-04 | ||
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases. Pssm-ID: 465626 Cd Length: 22 Bit Score: 37.95 E-value: 4.91e-04
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Blast search parameters | ||||
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