BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 130 KHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAY 209
Cdd:cd18202    1 KHGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKGAVSSHEAVVDLSGFCKSSFLPLLEFAY 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767926402 210 TSVLSFDFCSMADVAILARHLFMSEVLEICESVHKLME 247
Cdd:cd18202   81 TSELTFDFCSMAEVAMLARHLFMNEVLEICESVHKQME 118

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 605 MLKHTGVKPHACQV--CGKTFIYKHGLKLHQSL-HQSQKqfqcelcvksfVTKRSLQEHMSIHTGESK-YLCSVCGKSFH 680
Cdd:COG5189  341 MLKVKDGKPYKCPVegCNKKYKNQNGLKYHMLHgHQNQK-----------LHENPSPEKMNIFSAKDKpYRCEVCDKRYK 409

                         90
                 ....*....|..
gi 767926402 681 RGSGLSKHfKKH 692
Cdd:COG5189  410 NLNGLKYH-RKH 420

formate hydrogenlyase complex iron-sulfur subunit; Provisional

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767926402 492 KRDAKENTEEASHKCGECGMVF--QRRYALIMHKLKH------ERARDY--KCPLCKKQFQYSASLRAHLIRHTRK 557
Cdd:PRK12387 103 KEDLLQQSEFALCNCRVCGRPFavQKEIDYAIALLKHngdsraENHRESfeTCPECKRQKCLVPSDRIELTRHMKE 178

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 130 KHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAY 209
Cdd:cd18202    1 KHGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKGAVSSHEAVVDLSGFCKSSFLPLLEFAY 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767926402 210 TSVLSFDFCSMADVAILARHLFMSEVLEICESVHKLME 247
Cdd:cd18202   81 TSELTFDFCSMAEVAMLARHLFMNEVLEICESVHKQME 118

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402   150 DVTLLIEGEEYKAHKSVLSANSEYFRDLFiEKGAVSSHEAVVDLSGFCKASFLPLLEFAYTSVLSFDFCSMADVAILARH 229
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALF-SSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|..
gi 767926402   230 LFMSEVLEICES 241
Cdd:smart00225  80 LQIPGLVELCEE 91

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....
gi 767926402  835 SLKRHVRTHTGERPYVCPVCSEAY 858
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24

Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*.
gi 767926402  600 SLRIHMLKHTGVKPHACQVCGKTFIY 625
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

formate hydrogenlyase complex iron-sulfur subunit; Provisional

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767926402 492 KRDAKENTEEASHKCGECGMVF--QRRYALIMHKLKH------ERARDY--KCPLCKKQFQYSASLRAHLIRHTRK 557
Cdd:PRK12387 103 KEDLLQQSEFALCNCRVCGRPFavQKEIDYAIALLKHngdsraENHRESfeTCPECKRQKCLVPSDRIELTRHMKE 178

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 130 KHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAY 209
Cdd:cd18202    1 KHGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKGAVSSHEAVVDLSGFCKSSFLPLLEFAY 80

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767926402 210 TSVLSFDFCSMADVAILARHLFMSEVLEICESVHKLME 247
Cdd:cd18202   81 TSELTFDFCSMAEVAMLARHLFMNEVLEICESVHKQME 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 131 HCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEkGAVSSHEAVVDLSGFCKASFLPLLEFAYT 210
Cdd:cd18255    1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTG-GMRESSQDEIELKGVSAKGLKHILDFAYT 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767926402 211 SVLSFDFCSMADVAILARHLFMSEVLEICES 241
Cdd:cd18255   80 SELTLDLDCIQDVLGAAVHLQMLPVVELCEE 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 129 PKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEkGAVSSHEAVVDLSGFCKASFLPLLEFA 208
Cdd:cd18198    6 PDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTS-GAVVDQQNVYEIDFVSPEALTALLEFA 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767926402 209 YTSVLSFDFCSMADVAILARHLFMSEVLEIC 239
Cdd:cd18198   85 YTATLTVSTANVGDILSAARLLEIPCVSHVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 131 HCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAvSSHEAVVDLSGFCKASFLPLLEFAYT 210
Cdd:cd18306    1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSD-GESILTVKLDGLDPDAVEVLVNYAYT 79

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767926402 211 SVLSFDFCSMADVAILARHLFMSEVLEICES 241
Cdd:cd18306   80 SRLEVPADLVKSVYSAAKKLKMDRVKKACGD 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 131 HCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEK------------GAVSSHEAVVDLSGFCK 198
Cdd:cd18195    1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPlplgaaavaaapGATQSPERVLELPGVKA 80

                         90
                 ....*....|....*.
gi 767926402 199 ASFLPLLEFAYTSVLS 214
Cdd:cd18195   81 GVFSDVLNFIYSSRVA 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 131 HCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSS------HEAVVDLSGFCKASFLPL 204
Cdd:cd18228    2 HSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLvlvspaGKCVLDLHHVTVTGFAPL 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 767926402 205 LEFAYTSVLSFDFCSMADVAILARHLFMSEVLEICESVHK 244
Cdd:cd18228   82 LEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMK 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 131 HCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGavsSHEAVVDLSGFCKASFLPLLEFAYT 210
Cdd:cd18217    1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTE---DNIVFLDQSQVSADGFQKLLEFIYT 77

                         90       100       110
                 ....*....|....*....|....*....|
gi 767926402 211 SVLSFDFCSMADVAILARHLFMSEVLEICE 240
Cdd:cd18217   78 GNLNLDSWNVAEIHQAASYLGMEEVVAKCK 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 131 HCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEkgavSSHEAVVDLSGFCKASFLPLLEFAYT 210
Cdd:cd18221    1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQD----FTQEPLVEIEGVSNMAFRHLIEFTYT 76

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767926402 211 SVLSFDFCSMA-DVAILARHLFMSEVLEICESVHK 244
Cdd:cd18221   77 AKLMVQGEEEAnDVWKAAEYLQMQEAIKALEFRNK 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 129 PKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIeKGAVSSHEAVVDLSGFCKASFLPLLEFA 208
Cdd:cd18328    6 PNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFT-AGTLADQPYVYEIDFVTPEALSAILEFA 84

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767926402 209 YTSVLSFDFCSMADVAILARHLFMSEVLEIC 239
Cdd:cd18328   85 YTSTLTITTSNVKHILNAAQMLEIQCIINVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 131 HCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAYT 210
Cdd:cd18199    1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDVFSSDAFSIILDFVYS 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767926402 211 SVLSFDFCSMADVAILARHLFMSEVLEICES 241
Cdd:cd18199   81 GKLSLTSQNVIEVMSAASYLQMTDVINVCKT 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 128 SPKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFiEKGAVSSHEAVVDLSGFCKASFLPLLEF 207
Cdd:cd18261    8 SKSHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMF-SLCMVESEADEVNLHGVTSLGLKQALDF 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767926402 208 AYTSVLSFDFCSMADVAILARHLFMSEVLEICEsvHKLMEE 248
Cdd:cd18261   87 AYTGQILLEPGVIQDVLAAGSHLQLLELLSLCS--HYLIQE 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 130 KHCQAVLKQLNEQRLSN-QFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFA 208
Cdd:cd18207    8 QHSADMLHNLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPRELEMHTISSKVFGDILDFA 87

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 767926402 209 YTSVLSFDFCSMADVAILARHLFMSEVLEICESVHK 244
Cdd:cd18207   88 YTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIK 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 129 PKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFiekgAVSSHEAVVDLSGFCKASFLPLLEFA 208
Cdd:cd18289   10 PNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLF----SGNSKSAFELPATVPPACFQQILSFC 85

                         90       100
                 ....*....|....*....|....*....
gi 767926402 209 YTSVLSFDFCSMADVAILARHLFMSEVLE 237
Cdd:cd18289   86 YTGKLTMAASEQLVVMYTAGFLQIQHIVE 114

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402   150 DVTLLIEGEEYKAHKSVLSANSEYFRDLFiEKGAVSSHEAVVDLSGFCKASFLPLLEFAYTSVLSFDFCSMADVAILARH 229
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALF-SSDFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|..
gi 767926402   230 LFMSEVLEICES 241
Cdd:smart00225  80 LQIPGLVELCEE 91

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 131 HCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGA-VSSHeaVVDLSGFCKASFLPLLEFAY 209
Cdd:cd18223    1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSQEIwISSH--VLELPDLKAEVFAEILNFIY 78

                 ..
gi 767926402 210 TS 211
Cdd:cd18223   79 SS 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 124 VKRSSPKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLsgFCKASFLP 203
Cdd:cd18224    2 IKLHSSDHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLFLSTELDVARTYVVDF--ITPANFEK 79

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767926402 204 LLEFAYTSVLSFDFCSMADVAILARHLFMSEVLEICES 241
Cdd:cd18224   80 VLSFIYTSELFTDLINVGVIYEVAEKLGMEDLLKACHS 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 130 KHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSheAVVDL-SGFCKASFLPLLEFA 208
Cdd:cd18332    1 RHSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGV--SVLTLpSGLEARGFQLLLDFM 78

                         90       100       110
                 ....*....|....*....|....*....|.
gi 767926402 209 YTSVLSFDFCSMADVAILARHLFMSEVLEIC 239
Cdd:cd18332   79 YTSRLPLTPRTVPAVLAAATYLQMEHVVETC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 129 PKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLF-IEKGAVSSHEAVVDLSGFCKASFLPLLEF 207
Cdd:cd18196    2 PGHFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFtVAEGDQTMNMIQLDSEVVTAEAFAALIDM 81

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767926402 208 AYTSVLSFDFCSMADVAILARHLFMSEVLEICE 240
Cdd:cd18196   82 MYTSTLMLGESNVMDVLLAASHLHLNSVVKACK 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 123 VVKRSSPKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIekGAVSSHEAVVDLSGFCKASFL 202
Cdd:cd18277    2 VFAYESSVHSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIV--GQADAELNITLPEEVTVKGFE 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767926402 203 PLLEFAYTSVLSFDFCSMADVAILARHLFMSEVLEIC 239
Cdd:cd18277   80 PLIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 127 SSPKHCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFiEKGAVSSHEAVVDLSGFCKASFLPLLE 206
Cdd:cd18265    2 SGPCHAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMF-GGHLKESRQAVVEIQKVSAAAMEVLLD 80

                         90       100       110
                 ....*....|....*....|....*....|...
gi 767926402 207 FAYTSVLSFDFCSMADVAILARHLFMSEVLEIC 239
Cdd:cd18265   81 YMYGGGLRIQEDNVESVLEASDLLQVSKLREAC 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 131 HCQAVLKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFiEKGAVSSHEAVVDLSGFCKASFLPLLEFAYT 210
Cdd:cd18242    4 HAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMF-TSEMSEKGKSEVELQGLTASTMEILLDFVYT 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 136 LKQLNEQRLSNQFCDVTLLIEGEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASFLPLLEFAYTSVLSF 215
Cdd:cd18293    3 FLQLHRQQNSGVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAGQKVVLELQGLKAHTLLKLVDFLYTSELEV 82

                         90       100
                 ....*....|....*....|....
gi 767926402 216 DFCSMADVAILARHLFMSEVLEIC 239
Cdd:cd18293   83 SSEEAQDVLAAARRLQISELESLC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767926402 126 RSSPKHcqaVLKQLNEQRLSNQFCDVTLLIE----GEEYKAHKSVLSANSEYFRDLFIEKGAVSSHEAVVDLSGFCKASF 201
Cdd:cd18211    6 KSAPSN---LLNEMHKLRLLGHLCDVTVQVEhqgsKEEFSAHKAVLAASSKYFKEVFLNEKISDGKNTNVMLNEIYTADF 82