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Conserved domains on  [gi|755520025|ref|XP_011248984|]
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zinc finger protein 329 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-480 2.83e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 2.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025 225 RNSSLVLHHRTHTGEKPYTCNDCGKSFSKNYNLIVHRRIHTGEKPYKCSKCGKAFSDGSALTQHQRIHTGEKPYACLDCG 304
Cdd:COG5048  182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025 305 KTFNRNSSLILHQRTHTGE-------KPYRCNECGKPFTDISHLTVHLR--IHTGE--KPYEC--SRCGKAFRDGSYLTQ 371
Cdd:COG5048  262 RSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKR 341

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025 372 HERTHTGEKPFECV--ECGKSFSRNSH-----LIVHQKIHSGEKPYEC--KECGKTFIESAYLIRHQRVHTGEKPYGCN- 441
Cdd:COG5048  342 HILLHTSISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKn 421

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 755520025 442 -QCRKLFRNIAGLIRHQRIHTGERPYECNQCGKAFRDSSC 480
Cdd:COG5048  422 pPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
84-335 3.20e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 3.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025  84 STNPALLPSQRVPGTNGFHVFNSDIKTFDCDQTLHSCPPSYavkgtadgDACEKATQPSMEATQLVRNQMRekSYKYTES 163
Cdd:COG5048  200 SENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSL--------LSQSPSSLSSSDSSSSASESPR--SSLPTAS 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025 164 VKSLNHFTTALCDKKIK-KRSKRFYKGKDFGDILALSSSLNEKRSHSAE-KPYKCAE--CGKCFKRNSSLVLHHRTHTGE 239
Cdd:COG5048  270 SQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSVNHSGESlKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025 240 KPYTC--NDCGKSFSKNYN-----LIVHRRIHTGEKPYKC--SKCGKAFSDGSALTQHQRIHTGEKPYAC--LDCGKTFN 308
Cdd:COG5048  350 SPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFN 429

                        250       260
                 ....*....|....*....|....*..
gi 755520025 309 RNSSLILHQRTHTGEKPYRCNECGKPF 335
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKSFR 456
zf-H2C2_2 pfam13465
Zinc-finger double domain;
481-505 6.31e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.31e-03
                          10        20
                  ....*....|....*....|....*
gi 755520025  481 LTKHQRIHTKETPYQCLKCGKSFRQ 505
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-480 2.83e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 2.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025 225 RNSSLVLHHRTHTGEKPYTCNDCGKSFSKNYNLIVHRRIHTGEKPYKCSKCGKAFSDGSALTQHQRIHTGEKPYACLDCG 304
Cdd:COG5048  182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025 305 KTFNRNSSLILHQRTHTGE-------KPYRCNECGKPFTDISHLTVHLR--IHTGE--KPYEC--SRCGKAFRDGSYLTQ 371
Cdd:COG5048  262 RSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKR 341

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025 372 HERTHTGEKPFECV--ECGKSFSRNSH-----LIVHQKIHSGEKPYEC--KECGKTFIESAYLIRHQRVHTGEKPYGCN- 441
Cdd:COG5048  342 HILLHTSISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKn 421

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 755520025 442 -QCRKLFRNIAGLIRHQRIHTGERPYECNQCGKAFRDSSC 480
Cdd:COG5048  422 pPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 296-348 3.64e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.16  E-value: 3.64e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755520025 296 KPYaCLDCGKTFNRNSSLILHQRTHTgekpYRCNECGKPFTDISHLTVH-LRIH 348
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
453-475 4.54e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.54e-04
                          10        20
                  ....*....|....*....|...
gi 755520025  453 LIRHQRIHTGERPYECNQCGKAF 475
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
84-335 3.20e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 3.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025  84 STNPALLPSQRVPGTNGFHVFNSDIKTFDCDQTLHSCPPSYavkgtadgDACEKATQPSMEATQLVRNQMRekSYKYTES 163
Cdd:COG5048  200 SENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSL--------LSQSPSSLSSSDSSSSASESPR--SSLPTAS 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025 164 VKSLNHFTTALCDKKIK-KRSKRFYKGKDFGDILALSSSLNEKRSHSAE-KPYKCAE--CGKCFKRNSSLVLHHRTHTGE 239
Cdd:COG5048  270 SQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSVNHSGESlKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025 240 KPYTC--NDCGKSFSKNYN-----LIVHRRIHTGEKPYKC--SKCGKAFSDGSALTQHQRIHTGEKPYAC--LDCGKTFN 308
Cdd:COG5048  350 SPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFN 429

                        250       260
                 ....*....|....*....|....*..
gi 755520025 309 RNSSLILHQRTHTGEKPYRCNECGKPF 335
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKSFR 456
zf-H2C2_2 pfam13465
Zinc-finger double domain;
481-505 6.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.31e-03
                          10        20
                  ....*....|....*....|....*
gi 755520025  481 LTKHQRIHTKETPYQCLKCGKSFRQ 505
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-480 2.83e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 2.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025 225 RNSSLVLHHRTHTGEKPYTCNDCGKSFSKNYNLIVHRRIHTGEKPYKCSKCGKAFSDGSALTQHQRIHTGEKPYACLDCG 304
Cdd:COG5048  182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025 305 KTFNRNSSLILHQRTHTGE-------KPYRCNECGKPFTDISHLTVHLR--IHTGE--KPYEC--SRCGKAFRDGSYLTQ 371
Cdd:COG5048  262 RSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKR 341

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025 372 HERTHTGEKPFECV--ECGKSFSRNSH-----LIVHQKIHSGEKPYEC--KECGKTFIESAYLIRHQRVHTGEKPYGCN- 441
Cdd:COG5048  342 HILLHTSISPAKEKllNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKn 421

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 755520025 442 -QCRKLFRNIAGLIRHQRIHTGERPYECNQCGKAFRDSSC 480
Cdd:COG5048  422 pPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
209-541 6.52e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 6.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025 209 SAEKPYKCAECGKCFKRNSSLVLHHRTHTGEKPYTCND--CGKSFSKNYNLIVHRRIHTGEKPYKCSK------------ 274
Cdd:COG5048   29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKslplsnskasss 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025 275 ----CGKAFSDGSALTQHQRIHTGEKPYACLDCGKTFNRN-----------------------------------SSLIL 315
Cdd:COG5048  109 slssSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNnplpgnnsssvntpqsnslhpplpanslskdpssnLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025 316 HQRTHTGEKPYRCNECGKPFTDISHLTVHLRIHTGEKPYECSRCGKAFR------------------------------D 365
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPksllsqspsslsssdssssasesprsslptA 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025 366 GSYLTQHERTHTGE-----KPFECVECGKSFSRNSHLIVHQ--KIHSGE--KPYECKE--CGKTFIESAYLIRHQRVHTG 434
Cdd:COG5048  269 SSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025 435 EKPYGCNQCR-------KLFRNIAGLIRHQRIHTGERPYEC--NQCGKAFRDSSCLTKHQRIHTKETPYQC--LKCGKSF 503
Cdd:COG5048  349 ISPAKEKLLNssskfspLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSF 428

                        410       420       430
                 ....*....|....*....|....*....|....*...
gi 755520025 504 RQNTHLVVHQRLHNREGPSQCPHCGKIFRRSWCLARHQ 541
Cdd:COG5048  429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 296-348 3.64e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.16  E-value: 3.64e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755520025 296 KPYaCLDCGKTFNRNSSLILHQRTHTgekpYRCNECGKPFTDISHLTVH-LRIH 348
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
453-475 4.54e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.54e-04
                          10        20
                  ....*....|....*....|...
gi 755520025  453 LIRHQRIHTGERPYECNQCGKAF 475
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
256-280 4.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.72e-04
                          10        20
                  ....*....|....*....|....*
gi 755520025  256 NLIVHRRIHTGEKPYKCSKCGKAFS 280
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
284-309 7.71e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.71e-04
                          10        20
                  ....*....|....*....|....*.
gi 755520025  284 ALTQHQRIHTGEKPYACLDCGKTFNR 309
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
368-393 8.76e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.76e-04
                          10        20
                  ....*....|....*....|....*.
gi 755520025  368 YLTQHERTHTGEKPFECVECGKSFSR 393
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 261-344 1.47e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025 261 RRIHT-GEKPYKCS--KCGKAFSDGSALTQHqRIHTgekpyaclDCGKTFNRNSSLILHQRTHTGEKPYRCNECGKPFTD 337
Cdd:COG5189  340 RMLKVkDGKPYKCPveGCNKKYKNQNGLKYH-MLHG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKN 410


                 ....*..
gi 755520025 338 ISHLTVH 344
Cdd:COG5189  411 LNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
340-363 1.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.76e-03
                          10        20
                  ....*....|....*....|....
gi 755520025  340 HLTVHLRIHTGEKPYECSRCGKAF 363
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
396-419 1.87e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.87e-03
                          10        20
                  ....*....|....*....|....
gi 755520025  396 HLIVHQKIHSGEKPYECKECGKTF 419
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 242-264 2.35e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.35e-03
                          10        20
                  ....*....|....*....|...
gi 755520025  242 YTCNDCGKSFSKNYNLIVHRRIH 264
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
228-253 2.93e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.93e-03
                          10        20
                  ....*....|....*....|....*.
gi 755520025  228 SLVLHHRTHTGEKPYTCNDCGKSFSK 253
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 382-404 3.19e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.19e-03
                          10        20
                  ....*....|....*....|...
gi 755520025  382 FECVECGKSFSRNSHLIVHQKIH 404
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
84-335 3.20e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 3.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025  84 STNPALLPSQRVPGTNGFHVFNSDIKTFDCDQTLHSCPPSYavkgtadgDACEKATQPSMEATQLVRNQMRekSYKYTES 163
Cdd:COG5048  200 SENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSL--------LSQSPSSLSSSDSSSSASESPR--SSLPTAS 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025 164 VKSLNHFTTALCDKKIK-KRSKRFYKGKDFGDILALSSSLNEKRSHSAE-KPYKCAE--CGKCFKRNSSLVLHHRTHTGE 239
Cdd:COG5048  270 SQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRSVNHSGESlKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755520025 240 KPYTC--NDCGKSFSKNYN-----LIVHRRIHTGEKPYKC--SKCGKAFSDGSALTQHQRIHTGEKPYAC--LDCGKTFN 308
Cdd:COG5048  350 SPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFN 429

                        250       260
                 ....*....|....*....|....*..
gi 755520025 309 RNSSLILHQRTHTGEKPYRCNECGKPF 335
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKSFR 456
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 466-488 3.88e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.88e-03
                          10        20
                  ....*....|....*....|...
gi 755520025  466 YECNQCGKAFRDSSCLTKHQRIH 488
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 214-236 4.24e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.24e-03
                          10        20
                  ....*....|....*....|...
gi 755520025  214 YKCAECGKCFKRNSSLVLHHRTH 236
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 326-348 5.86e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.86e-03
                          10        20
                  ....*....|....*....|...
gi 755520025  326 YRCNECGKPFTDISHLTVHLRIH 348
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
481-505 6.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.31e-03
                          10        20
                  ....*....|....*....|....*
gi 755520025  481 LTKHQRIHTKETPYQCLKCGKSFRQ 505
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 298-320 8.85e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.85e-03
                          10        20
                  ....*....|....*....|...
gi 755520025  298 YACLDCGKTFNRNSSLILHQRTH 320
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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