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Conserved domains on  [gi|755505939|ref|XP_011248201|]
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coronin-2A isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 29-536 1.49e-97

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 304.89  E-value: 1.49e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939  29 SKFRHVYGKPASKENCYDSVPITRSVHD-NHFCAVNPHFIAVVTECAGGGAFLvipLHQT-GKLDPHYPKVCGHRGNVLD 106
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTAVL---KHTDyGKLASNPPILLGQEGPIID 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 107 IKWNPFNDFEIASCSEDATIKIWNIPKQLLTRNLTTYRKELIGHARRVGLVEWHPTTANILFSAGYDYKVMVWNLDTKDS 186
Cdd:PTZ00421  81 VAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 187 viagpVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLG-IVLQEASYKGHRANKVLFLGSLKKLLSTGTSRWN 265
Cdd:PTZ00421 161 -----VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGtIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQ 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 266 NRQMALWDQENLSVPLTEEDLDGSSGVLFPFFDSDTSMLYIVGKGDGNIRYYEVSMEKphLTYLTEYRSYNPQKGIGIMP 345
Cdd:PTZ00421 236 QRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMP 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 346 KRGLDVSSCEIFRFYKLiTTKSLIePVSMIVPRRS--ESYQEDIYPPTAAAQPSLTAHEWLSGMNRGPIMMSLRP----- 418
Cdd:PTZ00421 314 KWSLDTRKCEIARFYAL-TYHSLY-TIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAvfdgt 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 419 GSELLDSQTLPPERPLSNSMVQvSPQPLEPMKQPAEDGDQAPFSLLEEKLAKWTAEHHLGEKSCLTngfdvfecsppkte 498
Cdd:PTZ00421 392 SPELMGASALSPSGKPRHSGVS-VPASTSAMTHSFDDNTSKHADPCAMGVKRMDEGILDERLGRLQ-------------- 456

                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 755505939 499 nELLQMFYRQQEEIRRLRELLIQREVQTKQLELEIKNL 536
Cdd:PTZ00421 457 -ALSEKLRTQHEEIKRCREALQKKESIVMETLEKIQSI 493
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 29-536 1.49e-97

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 304.89  E-value: 1.49e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939  29 SKFRHVYGKPASKENCYDSVPITRSVHD-NHFCAVNPHFIAVVTECAGGGAFLvipLHQT-GKLDPHYPKVCGHRGNVLD 106
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTAVL---KHTDyGKLASNPPILLGQEGPIID 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 107 IKWNPFNDFEIASCSEDATIKIWNIPKQLLTRNLTTYRKELIGHARRVGLVEWHPTTANILFSAGYDYKVMVWNLDTKDS 186
Cdd:PTZ00421  81 VAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 187 viagpVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLG-IVLQEASYKGHRANKVLFLGSLKKLLSTGTSRWN 265
Cdd:PTZ00421 161 -----VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGtIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQ 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 266 NRQMALWDQENLSVPLTEEDLDGSSGVLFPFFDSDTSMLYIVGKGDGNIRYYEVSMEKphLTYLTEYRSYNPQKGIGIMP 345
Cdd:PTZ00421 236 QRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMP 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 346 KRGLDVSSCEIFRFYKLiTTKSLIePVSMIVPRRS--ESYQEDIYPPTAAAQPSLTAHEWLSGMNRGPIMMSLRP----- 418
Cdd:PTZ00421 314 KWSLDTRKCEIARFYAL-TYHSLY-TIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAvfdgt 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 419 GSELLDSQTLPPERPLSNSMVQvSPQPLEPMKQPAEDGDQAPFSLLEEKLAKWTAEHHLGEKSCLTngfdvfecsppkte 498
Cdd:PTZ00421 392 SPELMGASALSPSGKPRHSGVS-VPASTSAMTHSFDDNTSKHADPCAMGVKRMDEGILDERLGRLQ-------------- 456

                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 755505939 499 nELLQMFYRQQEEIRRLRELLIQREVQTKQLELEIKNL 536
Cdd:PTZ00421 457 -ALSEKLRTQHEEIKRCREALQKKESIVMETLEKIQSI 493
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 26-89 5.32e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 125.69  E-value: 5.32e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755505939   26 YRSSKFRHVYGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPLHQTGK 89
Cdd:pfam08953   3 VRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 98-327 6.00e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.20  E-value: 6.00e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939  98 CGHRGNVLDIKWNPFNDFeIASCSEDATIKIWNIPKQLLTRnlttyrkELIGHARRVGLVEWHPTTaNILFSAGYDYKVM 177
Cdd:cd00200   48 KGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLETGECVR-------TLTGHTSYVSSVAFSPDG-RILSSSSRDKTIK 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 178 VWNLDTKDsviagPVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGIVLQeaSYKGHRA--NKVLFLGSLKK 255
Cdd:cd00200  119 VWDVETGK-----CLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA--TLTGHTGevNSVAFSPDGEK 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755505939 256 LLSTGtsrwNNRQMALWDQENLSVPLT-EEDLDGSSGVLFpffdSDTSMLYIVGKGDGNIRYYEVSMEKPHLT 327
Cdd:cd00200  192 LLSSS----SDGTIKLWDLSTGKCLGTlRGHENGVNSVAF----SPDGYLLASGSEDGTIRVWDLRTGECVQT 256
WD40 COG2319
WD40 repeat [General function prediction only];
99-320 5.97e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.90  E-value: 5.97e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939  99 GHRGNVLDIKWNPFNDFeIASCSEDATIKIWNIPKQLLTRNLTtyrkeliGHARRVGLVEWHPTtANILFSAGYDYKVMV 178
Cdd:COG2319  160 GHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTLT-------GHTGAVRSVAFSPD-GKLLASGSADGTVRL 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 179 WNLDTKDsviagPVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGIVLQEASYKGHRANKVLFLGSLKKLLS 258
Cdd:COG2319  231 WDLATGK-----LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755505939 259 TGtsrwNNRQMALWDQENLSVPLTeedLDGSSGVLFPF-FDSDTSMLyIVGKGDGNIRYYEVS 320
Cdd:COG2319  306 GS----DDGTVRLWDLATGKLLRT---LTGHTGAVRSVaFSPDGKTL-ASGSDDGTVRLWDLA 360
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 191-227 1.41e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.41e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 755505939   191 PVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVD 227
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 29-536 1.49e-97

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 304.89  E-value: 1.49e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939  29 SKFRHVYGKPASKENCYDSVPITRSVHD-NHFCAVNPHFIAVVTECAGGGAFLvipLHQT-GKLDPHYPKVCGHRGNVLD 106
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQLGSTAVL---KHTDyGKLASNPPILLGQEGPIID 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 107 IKWNPFNDFEIASCSEDATIKIWNIPKQLLTRNLTTYRKELIGHARRVGLVEWHPTTANILFSAGYDYKVMVWNLDTKDS 186
Cdd:PTZ00421  81 VAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 187 viagpVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLG-IVLQEASYKGHRANKVLFLGSLKKLLSTGTSRWN 265
Cdd:PTZ00421 161 -----VEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGtIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQ 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 266 NRQMALWDQENLSVPLTEEDLDGSSGVLFPFFDSDTSMLYIVGKGDGNIRYYEVSMEKphLTYLTEYRSYNPQKGIGIMP 345
Cdd:PTZ00421 236 QRQIMLWDTRKMASPYSTVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNER--LTFCSSYSSVEPHKGLCMMP 313

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 346 KRGLDVSSCEIFRFYKLiTTKSLIePVSMIVPRRS--ESYQEDIYPPTAAAQPSLTAHEWLSGMNRGPIMMSLRP----- 418
Cdd:PTZ00421 314 KWSLDTRKCEIARFYAL-TYHSLY-TIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAvfdgt 391

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 419 GSELLDSQTLPPERPLSNSMVQvSPQPLEPMKQPAEDGDQAPFSLLEEKLAKWTAEHHLGEKSCLTngfdvfecsppkte 498
Cdd:PTZ00421 392 SPELMGASALSPSGKPRHSGVS-VPASTSAMTHSFDDNTSKHADPCAMGVKRMDEGILDERLGRLQ-------------- 456

                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 755505939 499 nELLQMFYRQQEEIRRLRELLIQREVQTKQLELEIKNL 536
Cdd:PTZ00421 457 -ALSEKLRTQHEEIKRCREALQKKESIVMETLEKIQSI 493
PTZ00420 PTZ00420
coronin; Provisional
 38-408 2.61e-65

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 222.52  E-value: 2.61e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939  38 PASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPLHQTGKlDPHYPKVCGHRGNVLDIKWNPFNDFEI 117
Cdd:PTZ00420  12 PDPSNNLFDDLRICSRVIDSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMR-KPPVIKLKGHTSSILDLQFNPCFSEIL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 118 ASCSEDATIKIWNIPKQllTRNLTTYRKE---LIGHARRVGLVEWHPTTANILFSAGYDYKVMVWNLDTKDSV--IAGPV 192
Cdd:PTZ00420  91 ASGSEDLTIRVWEIPHN--DESVKEIKDPqciLKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAfqINMPK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 193 KtinchqdvILSMSFNTNGSLLATTCKDRKIRIVDPRLgivlQEAS-----YKGHRANKVLFL----GSLKKLLSTGTSR 263
Cdd:PTZ00420 169 K--------LSSLKWNIKGNLLSGTCVGKHMHIIDPRK----QEIAssfhiHDGGKNTKNIWIdglgGDDNYILSTGFSK 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 264 WNNRQMALWDQENLSVPLTEEDLDGSSGVLFPFFDSDTSMLYIVGKGDGNIRYYEVSMEKphLTYLTEYRSYNPQKGIGI 343
Cdd:PTZ00420 237 NNMREMKLWDLKNTTSALVTMSIDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGS--IRKVNEYKSCSPFRSFGF 314

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755505939 344 MPKRGLDVSSCEIFRFYKlITTKSLIEPVSMIVPRRSES-YQEDIYPPTAAAQPSLTAHEWLSGMN 408
Cdd:PTZ00420 315 LPKQICDVYKCEIGRVYK-NENNSSIRPISFYVPRKNPTkFQEDLYPPILMHDPERSSRNWIDGKD 379
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 26-89 5.32e-35

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 125.69  E-value: 5.32e-35
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755505939   26 YRSSKFRHVYGKPASKENCYDSVPITRSVHDNHFCAVNPHFIAVVTECAGGGAFLVIPLHQTGK 89
Cdd:pfam08953   3 VRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 98-327 6.00e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.20  E-value: 6.00e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939  98 CGHRGNVLDIKWNPFNDFeIASCSEDATIKIWNIPKQLLTRnlttyrkELIGHARRVGLVEWHPTTaNILFSAGYDYKVM 177
Cdd:cd00200   48 KGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLETGECVR-------TLTGHTSYVSSVAFSPDG-RILSSSSRDKTIK 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 178 VWNLDTKDsviagPVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGIVLQeaSYKGHRA--NKVLFLGSLKK 255
Cdd:cd00200  119 VWDVETGK-----CLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA--TLTGHTGevNSVAFSPDGEK 191

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755505939 256 LLSTGtsrwNNRQMALWDQENLSVPLT-EEDLDGSSGVLFpffdSDTSMLYIVGKGDGNIRYYEVSMEKPHLT 327
Cdd:cd00200  192 LLSSS----SDGTIKLWDLSTGKCLGTlRGHENGVNSVAF----SPDGYLLASGSEDGTIRVWDLRTGECVQT 256
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 99-328 7.33e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.64  E-value: 7.33e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939  99 GHRGNVLDIKWNPFNDFeIASCSEDATIKIWNIPKQLLTRNLTtyrkeliGHARRVGLVEWHPTTaNILFSAGYDYKVMV 178
Cdd:cd00200    7 GHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGELLRTLK-------GHTGPVRDVAASADG-TYLASGSSDKTIRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 179 WNLDTKDsviagPVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGivLQEASYKGHRA--NKVLFLGSlKKL 256
Cdd:cd00200   78 WDLETGE-----CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG--KCLTTLRGHTDwvNSVAFSPD-GTF 149

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755505939 257 LSTGtsrWNNRQMALWDQENLSVpltEEDLDGSSG----VLFpffdSDTSMLYIVGKGDGNIRYYEVSMEKPHLTY 328
Cdd:cd00200  150 VASS---SQDGTIKLWDLRTGKC---VATLTGHTGevnsVAF----SPDGEKLLSSSSDGTIKLWDLSTGKCLGTL 215
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 99-318 8.44e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.78  E-value: 8.44e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939  99 GHRGNVLDIKWNPFNDFeIASCSEDATIKIWNIPKqlltrnlTTYRKELIGHARRVGLVEWHPTTaNILFSAGYDYKVMV 178
Cdd:cd00200   91 GHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVET-------GKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQDGTIKL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 179 WNLDTkdsviAGPVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGIVLQeaSYKGHRA--NKVLFLGSlKKL 256
Cdd:cd00200  162 WDLRT-----GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG--TLRGHENgvNSVAFSPD-GYL 233

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755505939 257 LSTGTSrwnNRQMALWDQENLSVPLTeedLDG-SSGVLFPFFDSDTSMLyIVGKGDGNIRYYE 318
Cdd:cd00200  234 LASGSE---DGTIRVWDLRTGECVQT---LSGhTNSVTSLAWSPDGKRL-ASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
99-320 5.97e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.90  E-value: 5.97e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939  99 GHRGNVLDIKWNPFNDFeIASCSEDATIKIWNIPKQLLTRNLTtyrkeliGHARRVGLVEWHPTtANILFSAGYDYKVMV 178
Cdd:COG2319  160 GHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTLT-------GHTGAVRSVAFSPD-GKLLASGSADGTVRL 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 179 WNLDTKDsviagPVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGIVLQEASYKGHRANKVLFLGSLKKLLS 258
Cdd:COG2319  231 WDLATGK-----LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755505939 259 TGtsrwNNRQMALWDQENLSVPLTeedLDGSSGVLFPF-FDSDTSMLyIVGKGDGNIRYYEVS 320
Cdd:COG2319  306 GS----DDGTVRLWDLATGKLLRT---LTGHTGAVRSVaFSPDGKTL-ASGSDDGTVRLWDLA 360
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 369-411 6.70e-19

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 79.86  E-value: 6.70e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 755505939  369 IEPVSMIVPRRS-ESYQEDIYPPTAAAQPSLTAHEWLSGMNRGP 411
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 COG2319
WD40 repeat [General function prediction only];
99-273 3.43e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.89  E-value: 3.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939  99 GHRGNVLDIKWNPfNDFEIASCSEDATIKIWNIPKQLLTRNLTtyrkeliGHARRVGLVEWHPTtANILFSAGYDYKVMV 178
Cdd:COG2319  244 GHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLT-------GHSGGVNSVAFSPD-GKLLASGSDDGTVRL 314

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 179 WNLDTKDsviagPVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGIVLQEasYKGHRA--NKVLFLGSLKKL 256
Cdd:COG2319  315 WDLATGK-----LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRT--LTGHTGavTSVAFSPDGRTL 387

                        170
                 ....*....|....*..
gi 755505939 257 LSTGtsrwNNRQMALWD 273
Cdd:COG2319  388 ASGS----ADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
99-229 4.02e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 4.02e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939  99 GHRGNVLDIKWNPFNDFeIASCSEDATIKIWNIPKQLLTRNLTtyrkeliGHARRVGLVEWHPTtANILFSAGYDYKVMV 178
Cdd:COG2319  286 GHSGGVNSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTLT-------GHTGAVRSVAFSPD-GKTLASGSDDGTVRL 356

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 755505939 179 WNLDTKdsviaGPVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPR 229
Cdd:COG2319  357 WDLATG-----ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
99-315 5.78e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 5.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939  99 GHRGNVLDIKWNPfNDFEIASCSEDATIKIWNIPKQLLTRNLTtyrkeliGHARRVGLVEWHPTtANILFSAGYDYKVMV 178
Cdd:COG2319   76 GHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLT-------GHTGAVRSVAFSPD-GKTLASGSADGTVRL 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 179 WNLDTkdsviAGPVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGIVLQeaSYKGHRA--NKVLFLGSLKKL 256
Cdd:COG2319  147 WDLAT-----GKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR--TLTGHTGavRSVAFSPDGKLL 219

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 257 LSTGtsrwNNRQMALWDQENLSVPLTeedLDG-SSGVLFPFFDSDTSMLYIVGkGDGNIR 315
Cdd:COG2319  220 ASGS----ADGTVRLWDLATGKLLRT---LTGhSGSVRSVAFSPDGRLLASGS-ADGTVR 271
WD40 COG2319
WD40 repeat [General function prediction only];
99-183 4.64e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 4.64e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939  99 GHRGNVLDIKWNPFNDFeIASCSEDATIKIWNIPKQLLTRNLTtyrkeliGHARRVGLVEWHPTtANILFSAGYDYKVMV 178
Cdd:COG2319  328 GHTGAVRSVAFSPDGKT-LASGSDDGTVRLWDLATGELLRTLT-------GHTGAVTSVAFSPD-GRTLASGSADGTVRL 398


                 ....*
gi 755505939 179 WNLDT 183
Cdd:COG2319  399 WDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 191-328 9.43e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 9.43e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 191 PVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVDPRLGIVLqeASYKGHRA--NKVLFLGSLKKLLSTGtsrwNNRQ 268
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELL--RTLKGHTGpvRDVAASADGTYLASGS----SDKT 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755505939 269 MALWDQENLSVPLTeedLDG-SSGVLFPFFDSDTSMLyIVGKGDGNIRYYEVSMEKPHLTY 328
Cdd:cd00200   75 IRLWDLETGECVRT---LTGhTSYVSSVAFSPDGRIL-SSSSRDKTIKVWDVETGKCLTTL 131
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 191-227 1.41e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 1.41e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 755505939   191 PVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVD 227
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 99-130 1.67e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.67e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 755505939    99 GHRGNVLDIKWNPFNDFeIASCSEDATIKIWN 130
Cdd:smart00320  10 GHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
99-130 7.46e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 7.46e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 755505939   99 GHRGNVLDIKWNPFNDFeIASCSEDATIKIWN 130
Cdd:pfam00400   9 GHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
191-227 1.13e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 1.13e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 755505939  191 PVKTINCHQDVILSMSFNTNGSLLATTCKDRKIRIVD 227
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 91-343 1.79e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.77  E-value: 1.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939  91 DPHYPKV-CGHRGNVLDIKWNPFNDFEIASCSEDATIKIWNIPK-QLLTrnlttyrkELIGHARRVGLVEWHPTTANILF 168
Cdd:PLN00181 521 DIHYPVVeLASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARsQLVT--------EMKEHEKRVWSIDYSSADPTLLA 592

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 169 SAGYDYKVMVWNLDTKDSViaGPVKTinchQDVILSMSFNTN-GSLLATTCKDRKIRIVD---PRLGIVLQEASYKghRA 244
Cdd:PLN00181 593 SGSDDGSVKLWSINQGVSI--GTIKT----KANICCVQFPSEsGRSLAFGSADHKVYYYDlrnPKLPLCTMIGHSK--TV 664

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755505939 245 NKVLFLGSlkkllSTGTSRWNNRQMALWDQENLSVPLTEEDLDGSSG--VLFPFFDSDTSMLYIVGKGDGN-IRYYEVSM 321
Cdd:PLN00181 665 SYVRFVDS-----STLVSSSTDNTLKLWDLSMSISGINETPLHSFMGhtNVKNFVGLSVSDGYIATGSETNeVFVYHKAF 739

                        250       260
                 ....*....|....*....|..
gi 755505939 322 EKPHLTYLteYRSYNPQKGIGI 343
Cdd:PLN00181 740 PMPVLSYK--FKTIDPVSGLEV 759
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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