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Conserved domains on  [gi|755539222|ref|XP_011247457|]
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solute carrier family 22 member 21 isoform X5 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 1000272)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates; similar to Drosophila melanogaster organic cation transporter protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A0119 super family cl36765
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 64-311 1.60e-114

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00898:

Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 341.61  E-value: 1.60e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222   64 FIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSETnklQDDSSKKPQsHHIYDLVRTPNIRILTIMSIILWL 143
Cdd:TIGR00898 262 FVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVLSLSLE---KDLSSSKKQ-YSFLDLFRTPNLRKTTLCLMMLWF 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  144 TISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLV 223
Cdd:TIGR00898 338 TTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALA 417

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  224 MVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFFPES 303
Cdd:TIGR00898 418 VLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPET 497


                  ....*...
gi 755539222  304 SGVSLPET 311
Cdd:TIGR00898 498 KGVPLPET 505
 
Name Accession Description Interval E-value
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 64-311 1.60e-114

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 341.61  E-value: 1.60e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222   64 FIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSETnklQDDSSKKPQsHHIYDLVRTPNIRILTIMSIILWL 143
Cdd:TIGR00898 262 FVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVLSLSLE---KDLSSSKKQ-YSFLDLFRTPNLRKTTLCLMMLWF 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  144 TISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLV 223
Cdd:TIGR00898 338 TTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALA 417

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  224 MVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFFPES 303
Cdd:TIGR00898 418 VLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPET 497


                  ....*...
gi 755539222  304 SGVSLPET 311
Cdd:TIGR00898 498 KGVPLPET 505
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 131-301 1.76e-95

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 287.44  E-value: 1.76e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 131 IRILTIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQL 210
Cdd:cd17376  172 IPITTIMSLLLWMAISVGYFGLSLNTPNLHGDPYLNCFLSAVIEVPAYIIAWLLLRSLPRRYSIAATLVLGGGVLLFIQL 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 211 VPSDLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLT 290
Cdd:cd17376  252 VPTDLQVLATALVMLGKFGITAAFSMVYVYTAELYPTVVRNMGVGVCSTASRIGSIISPYFVYLGAYDRYLPYILMGSLT 331

                        170
                 ....*....|.
gi 755539222 291 ILTAIITLFFP 301
Cdd:cd17376  332 VLIGILTLFLP 342
Sugar_tr pfam00083
Sugar (and other) transporter;
64-315 1.18e-14

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 74.62  E-value: 1.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222   64 FIPESPRWLISQGRIKEAEviiRKAAKINGIVAPSTIFDPSetnKLQDDSSKKPQSHHIYDLVRTPNIRILTIMSIILWL 143
Cdd:pfam00083 190 FLPESPRWLVEKGRLEEAR---EVLAKLRGVPDVDRELDEI---KDSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQI 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  144 TI------SVGYFGLSL-DTPNLNGNIYVNcFLLAAVEVPAYVLAWLLLQHVSRRY-------SMAG-SLFLGGSVLLLV 208
Cdd:pfam00083 264 FQqltginAIFYYSTTIfENLGLSDSFLVT-IIVGVVNFVFTFIAIFLVDRFGRRPllllgaaGMAIcFVILGIVALLGV 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  209 QLVPSdLHYLSTT--LVMVGKFGITSAySMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYF--VYLGAYDRRLPYI 284
Cdd:pfam00083 343 SKSDW-AGIVAIVfiALFIAFFAMGWG-PVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLfpIITDAIGLGYTFF 420

                         250       260       270
                  ....*....|....*....|....*....|..
gi 755539222  285 LMGSLTILTAIITLFF-PESSGVSLpETIDEM 315
Cdd:pfam00083 421 IFAGLLVLFIIFVFFFvPETKGRTL-EEIDEL 451
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
134-301 1.98e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 61.42  E-value: 1.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 134 LTIMSIILWL-TISVGYFGLSLDTpnlnGNIYVNCFLLAAVevPAYVLAWLLLQHVSRRYS--MAGSLFLGGSVLLLVQL 210
Cdd:COG2271  194 FALYGFLTWLpTYLVEVRGLSLAQ----AGLLLSLPFLAGI--VGSLLGGWLSDRLGRRRKlvLAIGLLLAALALLLLAL 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 211 VPSdlHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFV--YLGAYDRRLPYILMGS 288
Cdd:COG2271  268 LPS--PALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVgyLLDATGYQAAFLLLAA 345

                        170
                 ....*....|...
gi 755539222 289 LTILTAIITLFFP 301
Cdd:COG2271  346 LALLAALLALLLL 358
xylE PRK10077
D-xylose transporter XylE; Provisional
 64-93 1.36e-03

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 40.45  E-value: 1.36e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 755539222  64 FIPESPRWLISQGRIKEAEVIIRkaaKING 93
Cdd:PRK10077 213 FVPETPRYLMSRGKQEQAEGILR---KIMG 239
 
Name Accession Description Interval E-value
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 64-311 1.60e-114

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 341.61  E-value: 1.60e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222   64 FIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSETnklQDDSSKKPQsHHIYDLVRTPNIRILTIMSIILWL 143
Cdd:TIGR00898 262 FVPESPRWLISQGRIEEALKILQRIAKINGKKLPAEVLSLSLE---KDLSSSKKQ-YSFLDLFRTPNLRKTTLCLMMLWF 337

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  144 TISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLV 223
Cdd:TIGR00898 338 TTAFSYYGLVLDLGNLGGNIYLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALA 417

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  224 MVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFFPES 303
Cdd:TIGR00898 418 VLGKFGITSAFQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPET 497


                  ....*...
gi 755539222  304 SGVSLPET 311
Cdd:TIGR00898 498 KGVPLPET 505
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 131-301 1.76e-95

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 287.44  E-value: 1.76e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 131 IRILTIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQL 210
Cdd:cd17376  172 IPITTIMSLLLWMAISVGYFGLSLNTPNLHGDPYLNCFLSAVIEVPAYIIAWLLLRSLPRRYSIAATLVLGGGVLLFIQL 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 211 VPSDLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLT 290
Cdd:cd17376  252 VPTDLQVLATALVMLGKFGITAAFSMVYVYTAELYPTVVRNMGVGVCSTASRIGSIISPYFVYLGAYDRYLPYILMGSLT 331

                        170
                 ....*....|.
gi 755539222 291 ILTAIITLFFP 301
Cdd:cd17376  332 VLIGILTLFLP 342
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 135-301 7.75e-66

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 210.90  E-value: 7.75e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 135 TIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSD 214
Cdd:cd17317  165 TIIVGLIWFVTSLVYYGLSLNSSNLGGNLYLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDD 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 215 LHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTA 294
Cdd:cd17317  245 ENTLALTLALVGKFAISAAFSVIYLYTAELYPTVVRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFGVLALLGG 324


                 ....*..
gi 755539222 295 IITLFFP 301
Cdd:cd17317  325 LLTLLLP 331
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 131-301 4.36e-44

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 154.76  E-value: 4.36e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 131 IRILTIMSIIL---WLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLL 207
Cdd:cd17374  168 SWWLPKRTLILsfvWFANSFSYYGLSLDLQHLGLNVFLLQFLFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILA 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 208 VQLVPSDLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMG 287
Cdd:cd17374  248 NIFVPQEMQTLRTVLAVLGKGSSAAAFTISYVYTAELFPTVLRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIYG 327

                        170
                 ....*....|....
gi 755539222 288 SLTILTAIITLFFP 301
Cdd:cd17374  328 VLPILAGLLALLLP 341
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 135-301 5.22e-43

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 151.83  E-value: 5.22e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 135 TIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSD 214
Cdd:cd17375  175 TITVWLIWFTGSLGYYVFSLGSVNLGGNEYLNLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALACMLIMVIPQD 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 215 LHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTA 294
Cdd:cd17375  255 YEVLTIVLSMTGKFAIAIAFGLIYLYTAELYPTIVRSLAVGSGSMMCRVGSVVAPFCVYLSDVWIFLPQLLVGIMAFLSG 334


                 ....*..
gi 755539222 295 IITLFFP 301
Cdd:cd17375  335 ILTLMLP 341
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 135-301 4.72e-37

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 136.45  E-value: 4.72e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 135 TIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLLLQH--VSRRYSMAGSLFLGGSVLLLVQLVP 212
Cdd:cd17377  179 TLILMYVWFVCSLVYYGLTLNAGDLGGNIYLNLALSGLVELPAYPLCIYLINQkwSGRRRTLAGFLFLGGIACLLVMFVP 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 213 --SDLHYL----STTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILM 286
Cdd:cd17377  259 ekKDSGVFavvnSTSLSLLGKLTISAAFNIVYIYTSELYPTVVRNAGLGVCSMFSRVGGIIAPFIPSLKSVQWSLPFIVF 338

                        170
                 ....*....|....*
gi 755539222 287 GSLTILTAIITLFFP 301
Cdd:cd17377  339 GASGLSAGLLSLLLP 353
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 135-301 4.19e-35

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 130.93  E-value: 4.19e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 135 TIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSD 214
Cdd:cd17379  173 TFILMYAWFTSAVVYQGLIMRLGITGGNLYLDFFISALVELPAAFIILLTIDRIGRRLPFAASNIVAGAACLITAFIPPD 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 215 LHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVY-LGAYDRRLPYILMGSLTILT 293
Cdd:cd17379  253 LHWLKTTIACVGRLGITMAFEIVCLVNTELYPTFLRNLGVSVCSSLCDIGGIIAPFLLYrLAEIWLELPLIVFGVLALVA 332


                 ....*...
gi 755539222 294 AIITLFFP 301
Cdd:cd17379  333 GGLVLLLP 340
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 134-301 1.24e-34

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 129.84  E-value: 1.24e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 134 LTIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPS 213
Cdd:cd17446  172 ITFCLSLVWFSTSFAYYGLAMDLQKFGVSIYLIQIIFGAVDIPAKFISTLTMSYLGRRPTQAAALILAGIMILANIFVPQ 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 214 DLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILT 293
Cdd:cd17446  252 DLQTVRTALAVFGKGCLAASFNCVYLYTGELYPTVIRQTGMGLGSTMARLGGIVAPLVKMLGEYYPFLPLIIYGAAPILS 331


                 ....*...
gi 755539222 294 AIITLFFP 301
Cdd:cd17446  332 GIAACFLP 339
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 132-301 1.08e-31

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 121.70  E-value: 1.08e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 132 RILTIMsiILWLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLV 211
Cdd:cd17378  174 RLLAVM--VIGFGIGMVYYGIPLAVGNLKFNIYLSVALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFVL 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 212 PSDLH-YLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLT 290
Cdd:cd17378  252 SIGGTtSLQIALELVGFFGAAGAFNLLYIYTVELFPTCVRNAALGMLRQALVVGGIFAPFIVSLGRKNAALSFGVFGVAI 331

                        170
                 ....*....|.
gi 755539222 291 ILTAIITLFFP 301
Cdd:cd17378  332 LLLGLFALGLP 342
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 134-301 1.75e-28

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 112.90  E-value: 1.75e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 134 LTIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPS 213
Cdd:cd17447  174 ISLCTGIVWFGVAFTYYGISFNISGFGLNVYLTQFIYGAIELPAKLLAYLLLDRIGRRLTQAGSLILTGLSIGINILIPS 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 214 DLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILT 293
Cdd:cd17447  254 EFTVVRTVIAVLGKGFSEAAFTTVFLYTSELYPTVLRQNGMGYTSFIARLGGSLAPLVILLDDVWLSLPQVIFCGVALLA 333


                 ....*...
gi 755539222 294 AIITLFFP 301
Cdd:cd17447  334 GGVAFLLP 341
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 131-299 1.60e-18

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 85.35  E-value: 1.60e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 131 IRILTIMSIILWLTISVGYFGLSLDTPNL--------NGNIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGG 202
Cdd:cd17316  175 LRRRTLLLILLWFFISFGYYGLTTFLPTYlqtvlglsPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSG 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 203 SVLLLVQLVPSDLHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFV--YLGAYDRR 280
Cdd:cd17316  255 ILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIalLLASTGGT 334

                        170
                 ....*....|....*....
gi 755539222 281 LPYILMGSLTILTAIITLF 299
Cdd:cd17316  335 GVPALILALLAIVALIVAL 353
Sugar_tr pfam00083
Sugar (and other) transporter;
64-315 1.18e-14

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 74.62  E-value: 1.18e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222   64 FIPESPRWLISQGRIKEAEviiRKAAKINGIVAPSTIFDPSetnKLQDDSSKKPQSHHIYDLVRTPNIRILTIMSIILWL 143
Cdd:pfam00083 190 FLPESPRWLVEKGRLEEAR---EVLAKLRGVPDVDRELDEI---KDSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQI 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  144 TI------SVGYFGLSL-DTPNLNGNIYVNcFLLAAVEVPAYVLAWLLLQHVSRRY-------SMAG-SLFLGGSVLLLV 208
Cdd:pfam00083 264 FQqltginAIFYYSTTIfENLGLSDSFLVT-IIVGVVNFVFTFIAIFLVDRFGRRPllllgaaGMAIcFVILGIVALLGV 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  209 QLVPSdLHYLSTT--LVMVGKFGITSAySMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYF--VYLGAYDRRLPYI 284
Cdd:pfam00083 343 SKSDW-AGIVAIVfiALFIAFFAMGWG-PVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLfpIITDAIGLGYTFF 420

                         250       260       270
                  ....*....|....*....|....*....|..
gi 755539222  285 LMGSLTILTAIITLFF-PESSGVSLpETIDEM 315
Cdd:pfam00083 421 IFAGLLVLFIIFVFFFvPETKGRTL-EEIDEL 451
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 44-311 4.07e-14

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 73.14  E-value: 4.07e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222   44 ALYPCWNGTYIQLrgsICPGFIPESPRWLISQGRIKEAEVIIRK----AAKINGIVAPSTIFDPSETNKLqddSSKKPQS 119
Cdd:TIGR00879 198 PLGLQLIPAGLLF---LGLFFLPESPRWLVGKGRVEEARKSLARlrgtSGEDKELLDELELIDIKRSIEK---RSVQPSW 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  120 HHIYDLVRTPNIRILTI--MSIILWLT-ISVGYF---------GLSLDTPNLnGNIYVNCFLLAAVevpayVLAWLLLQH 187
Cdd:TIGR00879 272 GSLFSSTRRIRRRLFLGvvLQWFQQFTgINAIMYysptifenaGVSTDHAFL-VSIIVGAVNFAFT-----FVAIFLVDR 345

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  188 VSRR--------YSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGKFGI-TSAYSMVYVYTAELYPTVVRNMGVGVSS 258
Cdd:TIGR00879 346 FGRRpllligaaGMAICLFVLGILGASFVTGSSKSSGNVAIVFILLFIAFFaMGWGPVPWVIVSEIFPLSLRPKGISIAV 425

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 755539222  259 TASRLGSIL-SPYFVY-LGAYDRRLPYILMGSLTILTAIITLFF-PESSGVSLPET 311
Cdd:TIGR00879 426 AANWLANFIvGFLFPTmLESIGVGGVFIFFGGLNVLGLIFVYFFlPETKGRTLEEI 481
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 135-300 8.20e-12

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 65.63  E-value: 8.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 135 TIMSIILWLTISVGYFGLSLDTPNLN--GNI-------------------------YVNCFLLAAVEVPAYVLAWLLLQH 187
Cdd:cd17372  176 TLLLWVIWFGNAFAYYGVVLLTTELNnsHNVcgsksdsdsgesptekqcrnsndvdYRDVFIATFAEFPGLLISAAMIDR 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 188 VSRRYSMAGSLFLGGSVLLLVQLVPSdlHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSIL 267
Cdd:cd17372  256 LGRKASMASMLFTCCIFLLLLLICQS--PFILTVLLFGGRACISAAFTVVYIYTPEVYPTAVRALGVGTGSSVGRIGAIL 333

                        170       180       190
                 ....*....|....*....|....*....|...
gi 755539222 268 SPYFVYLGAYDRRLPYILMGSLTILTAIITLFF 300
Cdd:cd17372  334 CPFIAQVLVHGSQTIALLLFSVVCLVSAICVCL 366
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
134-301 1.98e-10

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 61.42  E-value: 1.98e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 134 LTIMSIILWL-TISVGYFGLSLDTpnlnGNIYVNCFLLAAVevPAYVLAWLLLQHVSRRYS--MAGSLFLGGSVLLLVQL 210
Cdd:COG2271  194 FALYGFLTWLpTYLVEVRGLSLAQ----AGLLLSLPFLAGI--VGSLLGGWLSDRLGRRRKlvLAIGLLLAALALLLLAL 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 211 VPSdlHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFV--YLGAYDRRLPYILMGS 288
Cdd:COG2271  268 LPS--PALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVgyLLDATGYQAAFLLLAA 345

                        170
                 ....*....|...
gi 755539222 289 LTILTAIITLFFP 301
Cdd:COG2271  346 LALLAALLALLLL 358
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 64-269 1.20e-09

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 59.29  E-value: 1.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222   64 FIPESPRWLISQGRikeaeviiRKAAKINGIVAPSTIFDPSETnkLQDDSSKKPQSHHIYDLVRTPnirILTIMSIILWL 143
Cdd:TIGR00895 191 FLPESIDFLVSKRP--------ETVRRIVNAIAPQMQAEAQSA--LPEQKSTQGTKRSVFKALFQG---KTARITVLLWL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  144 TIS---VGYFGLSLDTPNL----NGNIYVNCFLLAAVEVPAYVLAWL---LLQHVSRRYSMAGSLFLGGSVLLLVQLVPS 213
Cdd:TIGR00895 258 LYFmllVGVYFLTNWLPKLmvelGFSLSLAATGGALFNFGGVIGSIIfgwLADRLGPRVTALLLLLGAVFAVLVGSTLFS 337

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 755539222  214 DLHYLsTTLVMVGKFgITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSP 269
Cdd:TIGR00895 338 PTLLL-LLGAIAGFF-VNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGP 391
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 183-270 3.54e-09

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 57.51  E-value: 3.54e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 183 LLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYlsTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASR 262
Cdd:cd17442  258 LGINFLGRRLSLVITMGLTAIFFLLLNICTSSAGL--TIFLFMLRALVSANFNTVYIYTAEVYPTTMRALGMGTSGSLCR 335


                 ....*...
gi 755539222 263 LGSILSPY 270
Cdd:cd17442  336 IGAMVAPF 343
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 174-301 1.12e-08

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 55.97  E-value: 1.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 174 EVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSdlHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMG 253
Cdd:cd17441  246 EFPGLLVTLWIIDRFGRKKTMALCFFVFSFCTLLLFSCVG--RFSLTVLLFIARAFISGGFQAAYVYTPEVYPTATRALG 323

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 755539222 254 VGVSSTASRLGSILSPYFV-YLGAYDRRLPYILMGSLTILTAIITLFFP 301
Cdd:cd17441  324 LGTCSGMARVGALITPFIAqVMLESSVYLTLSVYSGCCLLAAIASCFLP 372
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 133-269 3.49e-08

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 54.51  E-value: 3.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 133 ILTIMSIILWLTISVG---YFGLSLDTPNL---------NGNIYVNCFLLAAVeVPAYVLAWLLLqHVSRRYSMAGSLFL 200
Cdd:cd17365  168 PLLRGTLLLWVTFFMGlllVYLLNSWLPKLmveagyslsQALTITLLLNIGGV-IGSLLLGWLAD-RFGPKRVLALFFAL 245

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755539222 201 GGSVLLLVQLVPSDLHYLSTTLVMVGkFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSP 269
Cdd:cd17365  246 GAVSLALLGVSPASLVLLYVLVFLAG-ACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGP 313
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 103-298 9.05e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 53.20  E-value: 9.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 103 PSETNKLQDDSSKKPQSHHIYDLVRTPNIRILTIMSII----------LWLTISVGYFGLSLDTPNLNGNIYVNCFLLAA 172
Cdd:cd06174  177 PESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLvnlayysfstLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGS 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 173 VevpayVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSdlHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNM 252
Cdd:cd06174  257 L-----LLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPS--LLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGT 329

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 755539222 253 GVGVSSTASRLGSILSPY---FVYLGAYDRRLPYILMGSLTILTAIITL 298
Cdd:cd06174  330 AFGLLNTFGFLGGAIGPLlagFLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 64-310 4.37e-07

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 51.42  E-value: 4.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  64 FIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSETNKLQDDSSKKPQShhiyDLVRTPNIRILTIMSIILWL 143
Cdd:cd17358  175 FIPESPRWLAKKGREEEAEKSLQFLRGKDADISKEAAEIQEELAELEKEAKESSFS----DLFQRKYLKPLVIGLGLMLF 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 144 TISVGYFGLSLDT--------PNLNGNIyvNCFLLAAVEVPAYVLAWLLLQHVSRRYSM--------AGSLFLGGSVLL- 206
Cdd:cd17358  251 QQLSGINAVIFYAssifdeagSGLDPNT--ATIIIGVVQVVGTLVATLLVDRLGRRPLLlvsaigmgIGLLALGLYFYLq 328

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 207 LVQLVPSDLHYLSTTLVMVGKFGITSA-YSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYF-----VYLGAYdrr 280
Cdd:cd17358  329 EHGALLSSVSWLPLVGLVIYIISFSIGlGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTfpfltLAWGAS--- 405

                        250       260       270
                 ....*....|....*....|....*....|.
gi 755539222 281 LPYILMGSLTILTAIITLFF-PESSGVSLPE 310
Cdd:cd17358  406 GTFWIFAGICGLALVFVLLFvPETKGKSLEE 436
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 169-304 6.89e-06

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 47.27  E-value: 6.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 169 LLAAVEVPAYVLAWLLLQHVSRRY-SMAGslFLGGSVLLLVQLVPSDLHYLSTTLVMV--------GKFGitsAYSMVYV 239
Cdd:cd17364  248 IALAGTVPGYWFTVFLIDRIGRKKiQMMG--FFGMTIFLLILAGPYDHWKISTIGFFVlygltfffSNFG---PNTTTFI 322

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755539222 240 YTAELYPTVVRNMGVGVSSTASRLGSILSPY-FVYLGA-YDRRLPYILMGSLTILTAIITLFFPESS 304
Cdd:cd17364  323 VPAEVFPARVRSTCHGISAASGKIGAIVGSFlFLSLTQnIGVRNVLIILAGVALLGIILTLLFPEEK 389
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
113-268 8.28e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 47.28  E-value: 8.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 113 SSKKPQSHHIYDLVRTPNIRILTIMSIILWLTISVGYFGLSL---DTPNLNGNIYVNCFLLAAV-EVPAYVLAWLLLQHV 188
Cdd:COG2814  191 AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLylqEVLGLSASAAGLLLALFGLgGVLGALLAGRLADRF 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 189 SRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVgkFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILS 268
Cdd:COG2814  271 GRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLG--FGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
MFS_1 pfam07690
Major Facilitator Superfamily;
135-314 8.30e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.03  E-value: 8.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  135 TIMSIILWLTISvGYFGLSLDTPNLNGNIYvncFLLAAVevpAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSD 214
Cdd:pfam07690  13 SLLGPALPLLLA-EDLGISPTEIGLLLTLF---SLGYAL---AQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  215 LhYLSTTLVMVGkFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYL--GAYDRRLPYILMGSLTIL 292
Cdd:pfam07690  86 W-LLLVLRVLQG-LGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLlaSLFGWRAAFLILAILSLL 163

                         170       180
                  ....*....|....*....|..
gi 755539222  293 TAIITLFFPESSGVSLPETIDE 314
Cdd:pfam07690 164 AAVLLLLPRPPPESKRPKPAEE 185
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 225-315 1.77e-05

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 46.09  E-value: 1.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 225 VGKFGITSAySMVYVYTAELYPTVVRNMGVGVSSTASRLG----SILSPYFVylGAYDRRLPYILMGSLTILTAIITLFF 300
Cdd:cd17356  312 IFSFATTWG-PIAWVYVAEVFPLRVRSKGMALATAFNWLWnfliSFFTPFII--GSIGFKYYYIFAGCNLLAFIVVFFFV 388

                         90
                 ....*....|....*
gi 755539222 301 PESSGVSLpETIDEM 315
Cdd:cd17356  389 PETKGLTL-EEIDEL 402
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 64-311 2.48e-05

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 45.72  E-value: 2.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  64 FIPESPRWL-ISQGRIKEAEVIIRKAAKINGIVAPSTifdpsETNKLQDDSSKKPQSHHIYDLVRTPNIRILTIMSIILW 142
Cdd:cd17357  192 FFPESPKFLlISKGDEEEAEKSLKFLRGIEDDVDQEL-----EEIKKESEQMGDQKQVSLMQLLRDPSLRLPLLLVLVVS 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 143 LTI-----------SVGYF---GLSLDTPnlngnIYVNcFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGG------ 202
Cdd:cd17357  267 ASQqfsginaiffySTFIFenaGFSPQLA-----EWAN-LGIGIVNVLSTIVGPFLIEKVGRRPLLLISLSVCAvalllm 340

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 203 SVLLLVQLVPSDLHYLSTTLVMVgkFGITsaYSMV-----YVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLgay 277
Cdd:cd17357  341 SVFLFLSEQNSWMSYGCIVAIFL--FIFF--FAIGlgpipWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPP--- 413

                        250       260       270
                 ....*....|....*....|....*....|....
gi 755539222 278 drrLPYILMGSLTILTAIITLFFPESSGVSLPET 311
Cdd:cd17357  414 ---LQSIGGGFVFIIFAIPCALFLLYLYRYLPET 444
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 168-303 3.39e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 45.11  E-value: 3.39e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 168 FLLAAVEVPAYVLAWL---LLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTtLVMVGkFGITSAYSMVYVYTAEL 244
Cdd:cd06174   35 LLFALFSLGYALLQPLaglLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLG-RFLLG-LGSGLIDPAVLALIADL 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755539222 245 YPTVVRNMGVGVSSTASRLGSILSP----YFVYLGAYDRRLPYILMGSLTILTAIITLFFPES 303
Cdd:cd06174  113 FPERERGRALGLLQAFGSVGGILGPllggILASSLGFGWRAVFLIAAALALLAAILLLLVVPD 175
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 183-302 3.63e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 45.26  E-value: 3.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 183 LLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMvgkfGITSAYSMV--YVYTAELYPTVVRNMGVGVSSTA 260
Cdd:cd17325   53 RLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQ----GLASAAVWPaaMALIADIAPPEERGRAMGIFSSA 128

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 755539222 261 SRLGSILSPYF--VYLGAYDRRLPYILMGSLTILTAIITLFFPE 302
Cdd:cd17325  129 IGLGFLIGPLLggLLADALGYRAPFLVCAALALLALVLALLLLP 172
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 167-301 4.72e-05

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 44.77  E-value: 4.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 167 CFLLAaveVPAYVLAWLLLQHVSRRYSMAGSLFL-----GGSVLLLVQLVPSDLHYLSTTLVMVGKFGITSAYSMVYVYT 241
Cdd:cd17445  210 SYLLS---TGTAGLACLFLCATVDRFGRRGILLLamtltGIASLILLGLMDYLNDAAIKTFSILGLFSSQAAASLSILFA 286

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 242 AELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFFP 301
Cdd:cd17445  287 AEVIPTVIRGSGLGLIMALGSLGGLSSPLMRLRNQHGYFLHHVVLASLALLAILSIMLLP 346
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 164-301 9.73e-05

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 43.61  E-value: 9.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 164 YVNCFLLAAVEVPAYVLAWLLLQHVSRR-YSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGKFGiTSAYSMVYV-YT 241
Cdd:cd17443  205 YLPYFLQAGLEALACIFLCLTVDRCGRRgVLLLGTIVTGLSSLLLLALTQYLHGGLVLVLSVVGLLA-SHAVSMLSMfFA 283

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 242 AELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFFP 301
Cdd:cd17443  284 AEVLPTVIRGAGLGLIMGAGFLGRAAGPLMELQNKQGYFLHHVVFASFAVLSVLCILLLP 343
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 64-303 1.07e-04

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 43.75  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  64 FIPESPRWLISQGRIKEAEVIIRKAAKINGIV--APSTIFdpsETNKLQDDSskkpqshhiydlvrtpnirilTIMSIIL 141
Cdd:cd17440  185 FMPESPRFLLEVGKHDEAWMILKQIHDTNMRArgQPEKVF---TVNRIKKDN---------------------TIKLTIV 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 142 WLTISVGYFGLS------------------------------------------LDTPNLNGNI---------YVNC--- 167
Cdd:cd17440  241 WLTLSFGYYGLSvwfpdvikhlqfksvtfedslfkscffedvtsvntyfrnctfIETVFYNTDLedykfidsdFINCtff 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 168 -----------------------FLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLvqlvpsdLHYLSTTLVM 224
Cdd:cd17440  321 hnktgcqitfdddysaywiyfvnFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFF-------LWFGTSESMM 393

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 225 VGKF----GIT-SAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPY-FVYLGAYDRRLPYILMGSLTILTAIITL 298
Cdd:cd17440  394 IGMLclynGLTiSAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLiFGSLVGITKAIPILLASTVLVCGGLVGL 473


                 ....*
gi 755539222 299 FFPES 303
Cdd:cd17440  474 RLPDT 478
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
114-302 1.52e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 43.33  E-value: 1.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 114 SKKPQSHHIYDLVRTPNIRILTIM---------SIILWL-TISVGYFGLSLDTPnlnGNIYvncFLLAAVEVPAYVLAWL 183
Cdd:COG2223  190 AAKASLRDQLEALRDPRFWLLSLLyfgtfgsfiGFSSWLpPYLVDQFGLSAATA---GLLA---ALFALLGALGRPLGGW 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 184 LLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGkFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRL 263
Cdd:COG2223  264 LSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLG-LALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGL 342

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 755539222 264 GSILSPYFV-----YLGAYdrRLPYILMGSLTILTAIITLFFPE 302
Cdd:COG2223  343 GGFLGPLLFgalldATGSY--TAAFLVFAVLALVALVLTLLLYR 384
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 93-300 1.57e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 43.33  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  93 GIVAPSTIFDPSETNKLQDDSSKKPQSHHIYDlvrtpNIRILTIMSIILwlTISVGYFGLSLDTPNLNGNIY-------- 164
Cdd:cd17474  165 AFLAILFLLPEPKEKAKSSSATKLRDLKKALR-----GRGLLTFLVSAF--LYFFLYFAFLTYLPFLLELLYgispiiig 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 165 -VNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSdlHYLSTTLVMVGKFGITSAYSMVYVYTAE 243
Cdd:cd17474  238 lLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPS--LALLLIAIVLFGLGLGLNLPLLTTLVTE 315

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 755539222 244 LYPTVVRNMGVGVSSTASRLGSILSPYF--VYLGAYDRRLPYILMGSLTILTAIITLFF 300
Cdd:cd17474  316 LAPEEERGTASSLYNFVRFLGQAVGPLLfgLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 64-303 1.87e-04

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 43.25  E-value: 1.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  64 FIPESPRWLISQGRIKEAEVIIRKAAKIN--GIVAPSTIFDPSetnklqddsskkpqshHIYdlvrtpniRILTIMSIIL 141
Cdd:cd17363  185 FMPESPRFLLEVGKHDEAWMILKQVHDTNmrAKGHPERVFTVS----------------HIK--------RMNTLFLAIV 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 142 WLTISVGYFGLS----------------------------------------------------LDTPNLNGN------- 162
Cdd:cd17363  241 WFTMSFSYYGLTvwfpdmikylqfedslfeecyfedvtstntffenctfintvfyntdlfeykfIDSRFLNSTfflkekc 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 163 -------------IYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDlhylSTTLVMVGKFG 229
Cdd:cd17363  321 gchlnddeenaylIYLVSFLGSLSVLPGNIVSALLMDKIGRLKMIGGSMLLSAVCCFFLFFGNSE----SAMIGLQCLFC 396

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755539222 230 ITS--AYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPY-FVYLGAYDRRLPYILMGSLTILTAIITLFFPES 303
Cdd:cd17363  397 GVSiaAWNALDVVTVELYPTDKRATAFGFLNGLCKLAAILGNSiFGSFVGITKVIPILLASAALVCGGLLALKLPET 473
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 102-300 2.05e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 42.95  E-value: 2.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 102 DPSETNKLQDDSSKKPQSHHIYDLVRTPNIRILTIMSIILWLTISVGYFGLSLDTPNLNG-NIYVNCFLLAAVEVPAYVL 180
Cdd:cd17325  172 PEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGlSPAQIGLLFGAQGLASALS 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 181 AWL---LLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGKFGITSAYSMVYVytAELYPTVVRNMGVGVS 257
Cdd:cd17325  252 QPPagkLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALL--ADIVPPEGRGTAMGLF 329

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 755539222 258 STASRLGSILSPyfVYLGA-YDR---RLPYILMGSLTILTAIITLFF 300
Cdd:cd17325  330 NTAFSLGMVLGP--LLGGFlYDAfgfATPFLAAAALLLLAAVLFLLL 374
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 163-305 2.35e-04

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 43.04  E-value: 2.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  163 IYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDlhylSTTLVMVGKFG--ITSAYSMVYVY 240
Cdd:TIGR01299 597 IYFVNFLGTLAVLPGNIVSALLMDKIGRLRMLAGSMVLSCISCFFLSFGNSE----SAMIALLCLFGglSIAAWNALDVL 672

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755539222  241 TAELYPTVVRNMGVGVSSTASRLGSILS-PYFVYLGAYDRRLPYILMGSLTILTAIITLFFPESSG 305
Cdd:TIGR01299 673 TVELYPSDKRATAFGFLNALCKAAAVLGiLIFGSFVGITKAAPILFASAALACGGLLALKLPDTRG 738
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
127-303 3.00e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 42.27  E-value: 3.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 127 RTPNIRILTIMSIILWLTISV-----GYFGLSLDTPNLNGNIYVNCFLLAAVeVPAYVLAWLLlQHVSRRYSMAGSLFLG 201
Cdd:COG2814    8 RWLALLALALGAFLSGLGIGIvlpalPLIAADLGASPAQAGLVVTAYLLGAA-LGAPLAGRLA-DRFGRRRVLLLGLLLF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 202 GSVLLLVQLVPSdLHYLSTTLVMVGkFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYL--GAYDR 279
Cdd:COG2814   86 ALGSLLCALAPS-LWLLLAARFLQG-LGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLlaDLFGW 163

                        170       180
                 ....*....|....*....|....*
gi 755539222 280 RLPYILMGSLTILTAIITLFF-PES 303
Cdd:COG2814  164 RWVFLVNAVLALLALLLLLRLlPES 188
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
183-298 3.38e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 42.16  E-value: 3.38e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 183 LLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSdLHYLSTTLVMVGkFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASR 262
Cdd:COG2271   67 LLADRFGRRRVLAIGLLLWGLATLLFGFATS-FWQLLLLRFLLG-LGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGP 144

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 755539222 263 LGSILSPYFVY--LGAYDRRLPYILMGSLTILTAIITL 298
Cdd:COG2271  145 LGGALAPPLLGwlLAAFGWRAAFLILGLPGLLLALLRF 182
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 185-299 9.33e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 40.63  E-value: 9.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 185 LQHVSRRYSMAGSLFLGGSVLLLVQLVPSdlHYLSTTLVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLG 264
Cdd:cd17319  242 LLRGARRLVIIIGLLLAAVGLLLAYLTTS--PVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLG 319

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 755539222 265 SILSPYFV-----YLGAYDrrLPYILMGSLTILTAIITLF 299
Cdd:cd17319  320 GFVAPLLIgylvdATGSYT--AAFLFLAAVALLAALLVLL 357
xylE PRK10077
D-xylose transporter XylE; Provisional
 64-93 1.36e-03

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 40.45  E-value: 1.36e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 755539222  64 FIPESPRWLISQGRIKEAEVIIRkaaKING 93
Cdd:PRK10077 213 FVPETPRYLMSRGKQEQAEGILR---KIMG 239
MFS_1 pfam07690
Major Facilitator Superfamily;
134-269 1.86e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.71  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  134 LTIMSIILWLTISVGYFGLSldtPNLNGNIYVNCFLLAAVevPAYVLAWLLLQHVSRR-YSMAGSLFLGGSVLLLVQLVP 212
Cdd:pfam07690 214 FAFFGLLTYLPLYQEVLGLS---ALLAGLLLGLGGLLGAI--GRLLLGRLSDRLGRRRrLLLALLLLILAALGLLLLSLT 288

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 755539222  213 SDLHYLSTTLVMVGkFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSP 269
Cdd:pfam07690 289 LSSLWLLLALLLLG-FGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 162-301 4.10e-03

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 38.65  E-value: 4.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 162 NIYVNCFLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGG--SVLLL--------------VQLVPSDLHYLSTTLVMV 225
Cdd:cd17373  193 NFYLDYYLTAGIAAVACVFLCVTVDFLGRRGGLLLFMILTGlaSLLLLgllnligkysqhpdSGMSDSVKDKFSIAFSVL 272

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755539222 226 GKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAIITLFFP 301
Cdd:cd17373  273 GLFASHAVGSLSVLFAAEVTPTVIRGGGLGLVLASGGLGMLTGPIIELHNQKGYFLQHVVFACCALLCILCILLLP 348
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 177-269 5.92e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 38.40  E-value: 5.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 177 AYVLAWLLLQhvsRRYSMAGSLFLGGSVLLLVQLVPSDlhylSTTLVMVGKFG----ITSAYSMVYVYTAELYPTVVRNM 252
Cdd:PRK11551 272 SLLIGALMDR---LRPRRVVLLIYAGILASLAALAAAP----SFAGMLLAGFAaglfVVGGQSVLYALAPLFYPTQVRGT 344

                         90
                 ....*....|....*..
gi 755539222 253 GVGVSSTASRLGSILSP 269
Cdd:PRK11551 345 GVGAAVAVGRLGSMAGP 361
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 156-299 6.54e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 38.28  E-value: 6.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 156 TPNLNGNIYVNCFLLAAV-EVPAYVLAWLLLQHVSRRysmagSLFLGGSVLLLVQLVPSdLHYLSTT----LVMVGKFGI 230
Cdd:cd17369  258 TLGVDRSTVLLAVLIASVvAAITIPLFGWLSDRVGRR-----PVYLAGALLAALFAFPF-FWLLDTGstwlIVLAAVVVL 331

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755539222 231 TSAYSMVY----VYTAELYPTVVRNMGVGVS-STASRLGSILSPYF-VYLGAYDRRLPYIL--MGSLTILTAIITLF 299
Cdd:cd17369  332 GVLHGMMYgpqaAFLAELFPTRVRYTGASLGyQLGAILGGGFAPLIaTALVAATGSWWPVAlyLAALAVISLVAALF 408
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
 238-310 6.98e-03

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 38.17  E-value: 6.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  238 YVYTAELYPTVVRNMGVGVSSTASRLGSILSPY-FVYL----GAYDRRLPYILMGSLTILTAII-------TLFFPESSG 305
Cdd:TIGR00887 414 FIVPGEVFPTRYRSTAHGISAASGKAGAIIGQFgFLYLaqhgDPTKGYPTGIWMGHVLEIFALFmflgilfTLLIPETKG 493


                  ....*
gi 755539222  306 VSLPE 310
Cdd:TIGR00887 494 KSLEE 498
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 64-303 7.40e-03

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 37.98  E-value: 7.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222  64 FIPESPRWLISQGRIKEAEVIIRKAAKIN--GIVAPSTIFDPSETNKLQddsskkpqshhiydlvrtpnirilTIMSIIL 141
Cdd:cd17438  185 FMPESPRFLLEMGKHDEAWMILKNIHDTNmrAKGTPEKVFTVSNIKRKN------------------------TLFLAVV 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 142 WLTISVGYFGLSLDTPNL-------------------------NGNIYVNC----------------------------- 167
Cdd:cd17438  241 WFTMAFSYYGLTVWFPDMirylqkhvtfedslfdecyfedvtsTDTYFKNCtiestifyntdlyehkfidcrfinstfle 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539222 168 ---------------------FLLAAVEVPAYVLAWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVG 226
Cdd:cd17438  321 qkegchmdfeedndfliylvsFLGSLSVLPGNIISALLMDKIGRIKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCG 400

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755539222 227 KfgITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSIL-SPYFVYLGAYDRRLPYILMGSLTILTAIITLFFPES 303
Cdd:cd17438  401 T--SIAAWNALDVITVELYPTNKRATAFGILNGLCKFAAILgNSIFASFVGITKVIPILLASTALVGGGLISLRLPET 476
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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