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Conserved domains on  [gi|755513620|ref|XP_011246494|]
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hepatocyte nuclear factor 1-alpha isoform X1 [Mus musculus]

Protein Classification

HNF-1B_C and HNF-1A_C domain-containing protein( domain architecture ID 11062438)

protein containing domains HNF-1_N, homeodomain, HNF-1B_C, and HNF-1A_C

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HNF-1B_C pfam04812
Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region ...
 165-421 9.13e-99

Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region found within the alpha isoform and at the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


:

Pssm-ID: 461438  Cd Length: 258  Bit Score: 298.45  E-value: 9.13e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513620  165 AMDTYnGPPPGPGPGPALPAHSSPGLPTTTLSPSKVHGVRYGQSATSEAAEVPSSSGG---PLVTVSAALHQVSPTGLEP 241
Cdd:pfam04812   1 AMDAY-SGPQPHSANPLLPHSSPHHPQPSASPPSKVQGVRYSQQGPSEVTSSSTISHHgnsAMVTSQSVLQQVSPVGLEP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513620  242 S-SLLSTEAKLVSATGGPLPPVSTLTALHSLeqTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGL 320
Cdd:pfam04812  80 ShSLLSTDAKMISVSGGGLPPVSTLTNLHSL--NSHHSPQQTQNLIMASLPGVMAIGPGETLSLEPNFTNTGGSQLVIGL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513620  321 ASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVAQSPFMATMAQLQSPHaLYSHKPEVAQYTHTSLL 400
Cdd:pfam04812 158 NSSQAQSVPVINSVGSSLATLQPVQFSQQLHSSHQQPLMQQSQSHMAQSPFMATMAQLQNSH-MYSHKQEPPQYSHTSLF 236

                         250       260
                  ....*....|....*....|..
gi 755513620  401 PQTMLITDT-NLSTLASLTPTK 421
Cdd:pfam04812 237 PSAMVITDTsSLSTLTSLTSTK 258
HNF-1_N super family cl24171
Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of ...
 1-51 2.62e-31

Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


The actual alignment was detected with superfamily member pfam04814:

Pssm-ID: 461440  Cd Length: 178  Bit Score: 119.15  E-value: 2.62e-31
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 755513620    1 MVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVR 51
Cdd:pfam04814 128 MIKGYLQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVR 178
HNF-1A_C pfam04813
Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus; This family consists of an ...
 423-510 8.72e-20

Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus; This family consists of an alternative C terminus of homeobox-containing transcription factor HNF-1, found in the HNF-1A isoform. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription, and HNF-1A, which has this C-terminal extension, transactivates less well than the B and C isoforms. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


:

Pssm-ID: 461439  Cd Length: 85  Bit Score: 83.67  E-value: 8.72e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513620  423 VFTSDTEASSEPGLHEPPSPATTIHIPSQDPSNiqhlQPAHRLSTSPTVSSSSLVLYQSSDS-NGHSHLLPSNHSVIETF 501
Cdd:pfam04813   1 VFTSDPETQSESGLHTPVSQADTIHIPNQDPAQ----QPGHRLSASPAVSSSSLVLYQSSDStNSHSHLLSSNHTVIETF 76


                  ....*....
gi 755513620  502 ISTQMASSS 510
Cdd:pfam04813  77 ISTQMASSS 85
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 83-156 3.13e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


:

Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 49.93  E-value: 3.13e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755513620  83 RRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNraeciqrgvspsqaqglgsnlVTEVRVYNWFANRRK 156
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELG---------------------LTERQVKIWFQNRRA 53
 
Name Accession Description Interval E-value
HNF-1B_C pfam04812
Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region ...
 165-421 9.13e-99

Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region found within the alpha isoform and at the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 461438  Cd Length: 258  Bit Score: 298.45  E-value: 9.13e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513620  165 AMDTYnGPPPGPGPGPALPAHSSPGLPTTTLSPSKVHGVRYGQSATSEAAEVPSSSGG---PLVTVSAALHQVSPTGLEP 241
Cdd:pfam04812   1 AMDAY-SGPQPHSANPLLPHSSPHHPQPSASPPSKVQGVRYSQQGPSEVTSSSTISHHgnsAMVTSQSVLQQVSPVGLEP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513620  242 S-SLLSTEAKLVSATGGPLPPVSTLTALHSLeqTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGL 320
Cdd:pfam04812  80 ShSLLSTDAKMISVSGGGLPPVSTLTNLHSL--NSHHSPQQTQNLIMASLPGVMAIGPGETLSLEPNFTNTGGSQLVIGL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513620  321 ASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVAQSPFMATMAQLQSPHaLYSHKPEVAQYTHTSLL 400
Cdd:pfam04812 158 NSSQAQSVPVINSVGSSLATLQPVQFSQQLHSSHQQPLMQQSQSHMAQSPFMATMAQLQNSH-MYSHKQEPPQYSHTSLF 236

                         250       260
                  ....*....|....*....|..
gi 755513620  401 PQTMLITDT-NLSTLASLTPTK 421
Cdd:pfam04812 237 PSAMVITDTsSLSTLTSLTSTK 258
HNF-1_N pfam04814
Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of ...
 1-51 2.62e-31

Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 461440  Cd Length: 178  Bit Score: 119.15  E-value: 2.62e-31
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 755513620    1 MVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVR 51
Cdd:pfam04814 128 MIKGYLQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVR 178
HNF-1A_C pfam04813
Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus; This family consists of an ...
 423-510 8.72e-20

Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus; This family consists of an alternative C terminus of homeobox-containing transcription factor HNF-1, found in the HNF-1A isoform. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription, and HNF-1A, which has this C-terminal extension, transactivates less well than the B and C isoforms. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 461439  Cd Length: 85  Bit Score: 83.67  E-value: 8.72e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513620  423 VFTSDTEASSEPGLHEPPSPATTIHIPSQDPSNiqhlQPAHRLSTSPTVSSSSLVLYQSSDS-NGHSHLLPSNHSVIETF 501
Cdd:pfam04813   1 VFTSDPETQSESGLHTPVSQADTIHIPNQDPAQ----QPGHRLSASPAVSSSSLVLYQSSDStNSHSHLLSSNHTVIETF 76


                  ....*....
gi 755513620  502 ISTQMASSS 510
Cdd:pfam04813  77 ISTQMASSS 85
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 83-156 3.13e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 49.93  E-value: 3.13e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755513620  83 RRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNraeciqrgvspsqaqglgsnlVTEVRVYNWFANRRK 156
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELG---------------------LTERQVKIWFQNRRA 53
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 82-156 2.07e-07

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 47.63  E-value: 2.07e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755513620    82 GRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNraeciqrgvspsqaqglgsnlVTEVRVYNWFANRRK 156
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLG---------------------LSERQVKVWFQNRRA 54
Homeodomain pfam00046
Homeodomain;
83-155 1.37e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 39.79  E-value: 1.37e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755513620   83 RRNRfkWGPASQQI--LFQAYERQKNPSKEERETLVEECNraeciqrgvspsqaqglgsnlVTEVRVYNWFANRR 155
Cdd:pfam00046   1 RRKR--TTFTPEQLeeLEKEFQENPYPSAEEREELAAQLG---------------------LTERQVKVWFQNRR 52
 
Name Accession Description Interval E-value
HNF-1B_C pfam04812
Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region ...
 165-421 9.13e-99

Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region found within the alpha isoform and at the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 461438  Cd Length: 258  Bit Score: 298.45  E-value: 9.13e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513620  165 AMDTYnGPPPGPGPGPALPAHSSPGLPTTTLSPSKVHGVRYGQSATSEAAEVPSSSGG---PLVTVSAALHQVSPTGLEP 241
Cdd:pfam04812   1 AMDAY-SGPQPHSANPLLPHSSPHHPQPSASPPSKVQGVRYSQQGPSEVTSSSTISHHgnsAMVTSQSVLQQVSPVGLEP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513620  242 S-SLLSTEAKLVSATGGPLPPVSTLTALHSLeqTSPGLNQQPQNLIMASLPGVMTIGPGEPASLGPTFTNTGASTLVIGL 320
Cdd:pfam04812  80 ShSLLSTDAKMISVSGGGLPPVSTLTNLHSL--NSHHSPQQTQNLIMASLPGVMAIGPGETLSLEPNFTNTGGSQLVIGL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513620  321 ASTQAQSVPVINSMGSSLTTLQPVQFSQPLHPSYQQPLMPPVQSHVAQSPFMATMAQLQSPHaLYSHKPEVAQYTHTSLL 400
Cdd:pfam04812 158 NSSQAQSVPVINSVGSSLATLQPVQFSQQLHSSHQQPLMQQSQSHMAQSPFMATMAQLQNSH-MYSHKQEPPQYSHTSLF 236

                         250       260
                  ....*....|....*....|..
gi 755513620  401 PQTMLITDT-NLSTLASLTPTK 421
Cdd:pfam04812 237 PSAMVITDTsSLSTLTSLTSTK 258
HNF-1_N pfam04814
Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of ...
 1-51 2.62e-31

Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 461440  Cd Length: 178  Bit Score: 119.15  E-value: 2.62e-31
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 755513620    1 MVKSYLQQHNIPQREVVDTTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVR 51
Cdd:pfam04814 128 MIKGYLQQHNIPQREVVDVTGLNQSHLSQHLNKGTPMKTQKRAALYTWYVR 178
HNF-1A_C pfam04813
Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus; This family consists of an ...
 423-510 8.72e-20

Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus; This family consists of an alternative C terminus of homeobox-containing transcription factor HNF-1, found in the HNF-1A isoform. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription, and HNF-1A, which has this C-terminal extension, transactivates less well than the B and C isoforms. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).


Pssm-ID: 461439  Cd Length: 85  Bit Score: 83.67  E-value: 8.72e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755513620  423 VFTSDTEASSEPGLHEPPSPATTIHIPSQDPSNiqhlQPAHRLSTSPTVSSSSLVLYQSSDS-NGHSHLLPSNHSVIETF 501
Cdd:pfam04813   1 VFTSDPETQSESGLHTPVSQADTIHIPNQDPAQ----QPGHRLSASPAVSSSSLVLYQSSDStNSHSHLLSSNHTVIETF 76


                  ....*....
gi 755513620  502 ISTQMASSS 510
Cdd:pfam04813  77 ISTQMASSS 85
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 83-156 3.13e-08

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 49.93  E-value: 3.13e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755513620  83 RRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNraeciqrgvspsqaqglgsnlVTEVRVYNWFANRRK 156
Cdd:cd00086    1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELG---------------------LTERQVKIWFQNRRA 53
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 82-156 2.07e-07

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 47.63  E-value: 2.07e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755513620    82 GRRNRFKWGPASQQILFQAYERQKNPSKEERETLVEECNraeciqrgvspsqaqglgsnlVTEVRVYNWFANRRK 156
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLG---------------------LSERQVKVWFQNRRA 54
Homeodomain pfam00046
Homeodomain;
83-155 1.37e-04

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 39.79  E-value: 1.37e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755513620   83 RRNRfkWGPASQQI--LFQAYERQKNPSKEERETLVEECNraeciqrgvspsqaqglgsnlVTEVRVYNWFANRR 155
Cdd:pfam00046   1 RRKR--TTFTPEQLeeLEKEFQENPYPSAEEREELAAQLG---------------------LTERQVKVWFQNRR 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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