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Conserved domains on  [gi|755566863|ref|XP_011246189|]
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uncharacterized protein LOC101055907 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
periphilin-like cd22896
Vertebrate periphilin-1 and similar proteins; This family contains periphilin (PPHLN1), a ...
 560-633 1.12e-39

Vertebrate periphilin-1 and similar proteins; This family contains periphilin (PPHLN1), a component of the Human Silencing Hub (HUSH) complex containing three proteins: periphilin, TASOR and MPP8 (also called MPHOSPH8) and mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (histone H3 lysine 9 trimethylation), as well as MORC2, a DNA-binding ATPase. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. In human, periphilin-1, the protein encoded by the gene PPHLN1, is involved in epithelial differentiation and contributes to epidermal integrity and barrier formation. It is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Oncogenic fusion protein of Fibroblast Growth Factor Receptor 2 (FGRF2) joined to periphilin 1, that occurs through a chromosomal translocation, is associated with intrahepatic cholangiocarcinoma; FGFR2-PPHLN1 activity requiring FGRF2-driven tyrosine kinase domain and PPHLN1 dimerization domain strongly drives cellular proliferation.


:

Pssm-ID: 439377  Cd Length: 74  Bit Score: 139.67  E-value: 1.12e-39
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755566863 560 SQLSSRTKAIISKTKQIEEVYLQYCETFAIVVKMLLDKDPSLQKSIQFALRQNLQEMSERCVEELNCFITEYDN 633
Cdd:cd22896    1 SLLDTRSKAIRAKKKEIEEAYRQDCETFGMVVKMLISKDPSLEKPIQFALRENLREIGERCVEELKDFIAEYDV 74
U2AF_lg super family cl36941
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 292-393 6.08e-08

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


The actual alignment was detected with superfamily member TIGR01642:

Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 55.67  E-value: 6.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  292 RDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSPQYARDRSSHyaRDRSPHYARDRSPHYARDRSPHYA 371
Cdd:TIGR01642   5 PDREREKSRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDRRRY--DSRSPRSLRYSSVRRSRDRPRRRS 82

                          90       100
                  ....*....|....*....|....*..
gi 755566863  372 RDRSS-----HYARDRSPQYARDRSSQ 393
Cdd:TIGR01642  83 RSVRSieqhrRRLRDRSPSNQWRKDDK 109
U2AF_lg super family cl36941
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 220-336 1.33e-06

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


The actual alignment was detected with superfamily member TIGR01642:

Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 51.43  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  220 RDRSPHYARDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPQYARDRSPHyaRDRSPQYARDRSSQYARDRSSQYA 299
Cdd:TIGR01642   5 PDREREKSRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDRRRY--DSRSPRSLRYSSVRRSRDRPRRRS 82

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 755566863  300 RDRSSQyARDRSSQYARDRSSQYARDRSSQYARDRSP 336
Cdd:TIGR01642  83 RSVRSI-EQHRRRLRDRSPSNQWRKDDKKRSLWDIKP 118
 
Name Accession Description Interval E-value
periphilin-like cd22896
Vertebrate periphilin-1 and similar proteins; This family contains periphilin (PPHLN1), a ...
 560-633 1.12e-39

Vertebrate periphilin-1 and similar proteins; This family contains periphilin (PPHLN1), a component of the Human Silencing Hub (HUSH) complex containing three proteins: periphilin, TASOR and MPP8 (also called MPHOSPH8) and mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (histone H3 lysine 9 trimethylation), as well as MORC2, a DNA-binding ATPase. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. In human, periphilin-1, the protein encoded by the gene PPHLN1, is involved in epithelial differentiation and contributes to epidermal integrity and barrier formation. It is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Oncogenic fusion protein of Fibroblast Growth Factor Receptor 2 (FGRF2) joined to periphilin 1, that occurs through a chromosomal translocation, is associated with intrahepatic cholangiocarcinoma; FGFR2-PPHLN1 activity requiring FGRF2-driven tyrosine kinase domain and PPHLN1 dimerization domain strongly drives cellular proliferation.


Pssm-ID: 439377  Cd Length: 74  Bit Score: 139.67  E-value: 1.12e-39
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755566863 560 SQLSSRTKAIISKTKQIEEVYLQYCETFAIVVKMLLDKDPSLQKSIQFALRQNLQEMSERCVEELNCFITEYDN 633
Cdd:cd22896    1 SLLDTRSKAIRAKKKEIEEAYRQDCETFGMVVKMLISKDPSLEKPIQFALRENLREIGERCVEELKDFIAEYDV 74
Lge1 pfam11488
Transcriptional regulatory protein LGE1; This family of proteins is conserved from fungi to ...
 559-628 8.30e-13

Transcriptional regulatory protein LGE1; This family of proteins is conserved from fungi to human. In yeasts it is involved in the ubiquitination of histones H2A and H2B. This ubiquitination step is a vital one in the regulation of the transcriptional activity of RNA polymerase II. In S. cerevisiae, Rad6 and Bre1 are present in a complex, also containing Lge1, that is required for H2B ubiquitination. Bre1 is the H2B ubiquitin ligase that interacts with acidic activators, such as Gal4, and recruits Rad6 and its binding partner Lge1 to target promoters. In S. pombe the equivalent protein to Lge1 appears to be Shf1. In human, periphilin acts a transcriptional co-repressor and regulates cell cycle progression.


Pssm-ID: 431907  Cd Length: 64  Bit Score: 63.43  E-value: 8.30e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  559 DSQLSSRTKAIISKTKQIEEVYLQYCETFAIVVKMLLDKDPSLQKSIQFALRQNLQEmsercvEELNCFI 628
Cdd:pfam11488   1 DLDDESTLKKIESKYKELEQLDKKLCELQLKVLKLELELDLLEEQAERDALNVQLTQ------EKLDEFL 64
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 292-393 6.08e-08

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 55.67  E-value: 6.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  292 RDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSPQYARDRSSHyaRDRSPHYARDRSPHYARDRSPHYA 371
Cdd:TIGR01642   5 PDREREKSRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDRRRY--DSRSPRSLRYSSVRRSRDRPRRRS 82

                          90       100
                  ....*....|....*....|....*..
gi 755566863  372 RDRSS-----HYARDRSPQYARDRSSQ 393
Cdd:TIGR01642  83 RSVRSieqhrRRLRDRSPSNQWRKDDK 109
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 220-336 1.33e-06

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 51.43  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  220 RDRSPHYARDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPQYARDRSPHyaRDRSPQYARDRSSQYARDRSSQYA 299
Cdd:TIGR01642   5 PDREREKSRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDRRRY--DSRSPRSLRYSSVRRSRDRPRRRS 82

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 755566863  300 RDRSSQyARDRSSQYARDRSSQYARDRSSQYARDRSP 336
Cdd:TIGR01642  83 RSVRSI-EQHRRRLRDRSPSNQWRKDDKKRSLWDIKP 118
Fibrinogen_BP pfam08017
Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family ...
 213-415 8.66e-06

Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family includes the fibrinogen receptor, FbsA, which mediates platelet aggregation.


Pssm-ID: 311808 [Multi-domain]  Cd Length: 393  Bit Score: 48.32  E-value: 8.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  213 DRSSHYARDRSPHYARDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPQYARDRSPHYARDRSPQYARDRSSQYAR 292
Cdd:pfam08017  80 ERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENKSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  293 DRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSPQYARDRSSHYARDRSPHYARDRSPHYARDRSPHYAR 372
Cdd:pfam08017 160 ERRQRDAENRSQGNVLERRQRDAENKSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVL 239

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 755566863  373 DRSSHYARDRSPQYARDRSSQYARDRSSHYARDRSSHYARDRS 415
Cdd:pfam08017 240 ERRQRDAENKSQGNVLERRQRDAENRSQGNVLERRQRDAENRS 282
Fibrinogen_BP pfam08017
Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family ...
 213-421 1.12e-05

Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family includes the fibrinogen receptor, FbsA, which mediates platelet aggregation.


Pssm-ID: 311808 [Multi-domain]  Cd Length: 393  Bit Score: 48.32  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  213 DRSSHYARDRSPHYARDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPQYARDRSPHYARDRSPQYARDRSSQYAR 292
Cdd:pfam08017  88 NRSQGNVLERRQRDAENRSQGNVLERRQRDAENKSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAE 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  293 DRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSPQYARDRSSHYARDRSPHYARDRSPHYARDRSPHYAR 372
Cdd:pfam08017 168 NRSQGNVLERRQRDAENKSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAE 247

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 755566863  373 DRSSHYARDRSPQYARDRSSQYARDRSSHYARDRSSHYARDRspHKRDA 421
Cdd:pfam08017 248 NKSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLER--RQRDA 294
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 211-428 1.08e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.55  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  211 PRDRSSHYARDRSP---HYARDRSPHYARDRppqyARDRSSQYARDRSPQYARDRSPQYARDRSPHYARDRSPQYARDRS 287
Cdd:PHA03307  198 PPAAASPRPPRRSSpisASASSPAPAPGRSA----ADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEAS 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  288 SQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSPQyardrSSHYARDRSPHYARDRSPHYARDRS 367
Cdd:PHA03307  274 GWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRE-----SSSSSTSSSSESSRGAAVSPGPSPS 348

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755566863  368 PHYARDRSSHyARDRSPQYARDRSSQYARDRSSHYARD--RSSHYARDRSPHKRDAPFVREST 428
Cdd:PHA03307  349 RSPSPSRPPP-PADPSSPRKRPRPSRAPSSPAASAGRPtrRRARAAVAGRARRRDATGRFPAG 410
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 70-384 5.20e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.24  E-value: 5.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863   70 PKRPPLLDKIPPQVVN-VPKRPPLLDKIPPRVVNVPKKPPLLDKIPPQVVNVPKKPPLLDKIPPQVVNVPKKPPPLFDNI 148
Cdd:PHA03307  117 PPPTPPPASPPPSPAPdLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPS 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  149 PPLLARPGDGY--YSHDAFRVCDEGQSFFRDQRRSRRNYHSASWQPNYRNRRGGLRRKTFSSHHprdrsshyARDRSPHY 226
Cdd:PHA03307  197 TPPAAASPRPPrrSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRP--------APITLPTR 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  227 ARDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPqyARDRSPHYARDRSPqyarDRSSQYARDRSSQyarDRSSQY 306
Cdd:PHA03307  269 IWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSG--PAPSSPRASSSSSS----SRESSSSSTSSSS---ESSRGA 339

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755566863  307 ARDRSSQYARDRSSQYARDRSsqyarDRSPQYARDRSSHYARDRSPHYARDRSPHYARDRSPHY-ARDRSSHYARDRSP 384
Cdd:PHA03307  340 AVSPGPSPSRSPSPSRPPPPA-----DPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRArRRDATGRFPAGRPR 413
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 219-420 2.53e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 41.04  E-value: 2.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863 219 ARDRSPHYARDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPQYARDRSPHYARDRSPQYARDRSSQYARDRSSQY 298
Cdd:PRK12678  58 ARGGGAAAAAATPAAPAAAARRAARAAAAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERGEAA 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863 299 ARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSPQYARDRSSHYARDRSPHYARDRSPHYARDRsphyARDRSSHY 378
Cdd:PRK12678 138 RRGAARKAGEGGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDR----RDRREQGD 213

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 755566863 379 ARDRSPQyaRDRSSQYARDRSSHYARDRSSHYARDRSPHKRD 420
Cdd:PRK12678 214 RREERGR--RDGGDRRGRRRRRDRRDARGDDNREDRGDRDGD 253
 
Name Accession Description Interval E-value
periphilin-like cd22896
Vertebrate periphilin-1 and similar proteins; This family contains periphilin (PPHLN1), a ...
 560-633 1.12e-39

Vertebrate periphilin-1 and similar proteins; This family contains periphilin (PPHLN1), a component of the Human Silencing Hub (HUSH) complex containing three proteins: periphilin, TASOR and MPP8 (also called MPHOSPH8) and mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3 (histone H3 lysine 9 trimethylation), as well as MORC2, a DNA-binding ATPase. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. In human, periphilin-1, the protein encoded by the gene PPHLN1, is involved in epithelial differentiation and contributes to epidermal integrity and barrier formation. It is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. The cellular localization pattern and insolubility of this protein suggest that it may play a role in epithelial differentiation and contribute to epidermal integrity and barrier formation. Oncogenic fusion protein of Fibroblast Growth Factor Receptor 2 (FGRF2) joined to periphilin 1, that occurs through a chromosomal translocation, is associated with intrahepatic cholangiocarcinoma; FGFR2-PPHLN1 activity requiring FGRF2-driven tyrosine kinase domain and PPHLN1 dimerization domain strongly drives cellular proliferation.


Pssm-ID: 439377  Cd Length: 74  Bit Score: 139.67  E-value: 1.12e-39
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755566863 560 SQLSSRTKAIISKTKQIEEVYLQYCETFAIVVKMLLDKDPSLQKSIQFALRQNLQEMSERCVEELNCFITEYDN 633
Cdd:cd22896    1 SLLDTRSKAIRAKKKEIEEAYRQDCETFGMVVKMLISKDPSLEKPIQFALRENLREIGERCVEELKDFIAEYDV 74
Lge1 pfam11488
Transcriptional regulatory protein LGE1; This family of proteins is conserved from fungi to ...
 559-628 8.30e-13

Transcriptional regulatory protein LGE1; This family of proteins is conserved from fungi to human. In yeasts it is involved in the ubiquitination of histones H2A and H2B. This ubiquitination step is a vital one in the regulation of the transcriptional activity of RNA polymerase II. In S. cerevisiae, Rad6 and Bre1 are present in a complex, also containing Lge1, that is required for H2B ubiquitination. Bre1 is the H2B ubiquitin ligase that interacts with acidic activators, such as Gal4, and recruits Rad6 and its binding partner Lge1 to target promoters. In S. pombe the equivalent protein to Lge1 appears to be Shf1. In human, periphilin acts a transcriptional co-repressor and regulates cell cycle progression.


Pssm-ID: 431907  Cd Length: 64  Bit Score: 63.43  E-value: 8.30e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  559 DSQLSSRTKAIISKTKQIEEVYLQYCETFAIVVKMLLDKDPSLQKSIQFALRQNLQEmsercvEELNCFI 628
Cdd:pfam11488   1 DLDDESTLKKIESKYKELEQLDKKLCELQLKVLKLELELDLLEEQAERDALNVQLTQ------EKLDEFL 64
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 292-393 6.08e-08

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 55.67  E-value: 6.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  292 RDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSPQYARDRSSHyaRDRSPHYARDRSPHYARDRSPHYA 371
Cdd:TIGR01642   5 PDREREKSRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDRRRY--DSRSPRSLRYSSVRRSRDRPRRRS 82

                          90       100
                  ....*....|....*....|....*..
gi 755566863  372 RDRSS-----HYARDRSPQYARDRSSQ 393
Cdd:TIGR01642  83 RSVRSieqhrRRLRDRSPSNQWRKDDK 109
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 308-419 2.68e-07

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 53.74  E-value: 2.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  308 RDRSSQYARDRSSQYARDRSSQYARDRSPQYARDRSSHYARDRSPHYARDRSPHyaRDRSPHYARDRSSHYARDRSPQYA 387
Cdd:TIGR01642   5 PDREREKSRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDRRRY--DSRSPRSLRYSSVRRSRDRPRRRS 82

                          90       100       110
                  ....*....|....*....|....*....|..
gi 755566863  388 RDRSSQyarDRSSHYARDRSSHYARDRSPHKR 419
Cdd:TIGR01642  83 RSVRSI---EQHRRRLRDRSPSNQWRKDDKKR 111
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 276-376 4.35e-07

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 52.97  E-value: 4.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  276 RDRSPQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQyaRDRSPQYARDRSSHYARDRSPHYA 355
Cdd:TIGR01642   5 PDREREKSRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDRRRY--DSRSPRSLRYSSVRRSRDRPRRRS 82

                          90       100
                  ....*....|....*....|....*.
gi 755566863  356 RDRSP-----HYARDRSPHYARDRSS 376
Cdd:TIGR01642  83 RSVRSieqhrRRLRDRSPSNQWRKDD 108
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 260-352 6.94e-07

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 52.20  E-value: 6.94e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  260 RDRSPQYARDRSPHYARDRSPQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQyaRDRSSQYARDRSPQYA 339
Cdd:TIGR01642   5 PDREREKSRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDRRRYDSRSPRSL--RYSSVRRSRDRPRRRS 82

                          90
                  ....*....|....*...
gi 755566863  340 RDRSS-----HYARDRSP 352
Cdd:TIGR01642  83 RSVRSieqhrRRLRDRSP 100
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 316-428 7.81e-07

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 52.23  E-value: 7.81e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  316 RDRSSQyaRDRSSQYARDRSPQyaRDRSSHYARDRSphyaRDRSPHYARDRSPHYARDrsshYARDRSPQYARDRSSQYA 395
Cdd:TIGR01622   3 RDRERE--RLRDSSSAGDRDRR--RDKGRERSRDRS----RDRERSRSRRRDRHRDRD----YYRGRERRSRSRRPNRRY 70

                          90       100       110
                  ....*....|....*....|....*....|...
gi 755566863  396 RDRSSHYARDRSSHYARDRSPHKRDAPFVREST 428
Cdd:TIGR01622  71 RPREKRRRRGDSYRRRRDDRRSRREKPRARDGT 103
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 220-336 1.33e-06

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 51.43  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  220 RDRSPHYARDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPQYARDRSPHyaRDRSPQYARDRSSQYARDRSSQYA 299
Cdd:TIGR01642   5 PDREREKSRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDRRRY--DSRSPRSLRYSSVRRSRDRPRRRS 82

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 755566863  300 RDRSSQyARDRSSQYARDRSSQYARDRSSQYARDRSP 336
Cdd:TIGR01642  83 RSVRSI-EQHRRRLRDRSPSNQWRKDDKKRSLWDIKP 118
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 228-344 2.00e-06

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 50.66  E-value: 2.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  228 RDRSPHYARDRPPQYARDRSSQYARDRSpqyaRDRSPQYARDRSPHYARDRSPQYARDRSSQYARDRSSQYARDRSSQYA 307
Cdd:TIGR01642   1 RDEEPDREREKSRGRDRDRSSERPRRRS----RDRSRFRDRHRRSRERSYREDSRPRDRRRYDSRSPRSLRYSSVRRSRD 76

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 755566863  308 RDRSSQYARDRSSQYARDrssqyARDRSPQYARDRSS 344
Cdd:TIGR01642  77 RPRRRSRSVRSIEQHRRR-----LRDRSPSNQWRKDD 108
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 244-360 2.04e-06

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 50.69  E-value: 2.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  244 RDRSSQYARDRSPQYARDRSpqyaRDRSPHYARDRSPQyaRDRSSQYARDRSsqyaRDRSsqYARDRSSQYARDRSSQYA 323
Cdd:TIGR01622   3 RDRERERLRDSSSAGDRDRR----RDKGRERSRDRSRD--RERSRSRRRDRH----RDRD--YYRGRERRSRSRRPNRRY 70

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 755566863  324 RDRSSQyaRDRSPQYARDRSSHYARdRSPHYARDRSP 360
Cdd:TIGR01622  71 RPREKR--RRRGDSYRRRRDDRRSR-REKPRARDGTP 104
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 308-420 4.19e-06

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 49.53  E-value: 4.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  308 RDRSSQYARDRSSQYARDRSsqyaRDRSPQYARDRSShyARDRSphyaRDRSPHYARDRSPHYARDRSSHYARDRSpqya 387
Cdd:TIGR01622   3 RDRERERLRDSSSAGDRDRR----RDKGRERSRDRSR--DRERS----RSRRRDRHRDRDYYRGRERRSRSRRPNR---- 68

                          90       100       110
                  ....*....|....*....|....*....|...
gi 755566863  388 RDRSSQYARDRSSHYARDRSSHYARDRSPHKRD 420
Cdd:TIGR01622  69 RYRPREKRRRRGDSYRRRRDDRRSRREKPRARD 101
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 284-393 4.23e-06

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 49.53  E-value: 4.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  284 RDRSSQYARDRSSQYARDRSsqyaRDRSSQYARDRSSQYARDRSSQYARDRSPQYARDRSSHYARDRSPHYARDRSPhyA 363
Cdd:TIGR01622   3 RDRERERLRDSSSAGDRDRR----RDKGRERSRDRSRDRERSRSRRRDRHRDRDYYRGRERRSRSRRPNRRYRPREK--R 76

                          90       100       110
                  ....*....|....*....|....*....|
gi 755566863  364 RDRSPHYARDRSSHYARdRSPQYARDRSSQ 393
Cdd:TIGR01622  77 RRRGDSYRRRRDDRRSR-REKPRARDGTPE 105
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 300-416 4.90e-06

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 49.53  E-value: 4.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  300 RDRSSQYARDRSSQYARDRSsqyaRDRSSQYARDRSPQyaRDRSSHYARDRSphyaRDRSPHyaRDRSPHYARDRSSHYA 379
Cdd:TIGR01622   3 RDRERERLRDSSSAGDRDRR----RDKGRERSRDRSRD--RERSRSRRRDRH----RDRDYY--RGRERRSRSRRPNRRY 70

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 755566863  380 RDRSPQYARDRSSQYARDRSSHyarDRSSHYARDRSP 416
Cdd:TIGR01622  71 RPREKRRRRGDSYRRRRDDRRS---RREKPRARDGTP 104
Fibrinogen_BP pfam08017
Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family ...
 213-415 8.66e-06

Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family includes the fibrinogen receptor, FbsA, which mediates platelet aggregation.


Pssm-ID: 311808 [Multi-domain]  Cd Length: 393  Bit Score: 48.32  E-value: 8.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  213 DRSSHYARDRSPHYARDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPQYARDRSPHYARDRSPQYARDRSSQYAR 292
Cdd:pfam08017  80 ERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENKSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVL 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  293 DRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSPQYARDRSSHYARDRSPHYARDRSPHYARDRSPHYAR 372
Cdd:pfam08017 160 ERRQRDAENRSQGNVLERRQRDAENKSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVL 239

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 755566863  373 DRSSHYARDRSPQYARDRSSQYARDRSSHYARDRSSHYARDRS 415
Cdd:pfam08017 240 ERRQRDAENKSQGNVLERRQRDAENRSQGNVLERRQRDAENRS 282
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 228-337 1.04e-05

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 48.38  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  228 RDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPQYARDRSPHyaRDRSPQyaRDRSSQYARDRSSQYARDRSSQya 307
Cdd:TIGR01622   3 RDRERERLRDSSSAGDRDRRRDKGRERSRDRSRDRERSRSRRRDRH--RDRDYY--RGRERRSRSRRPNRRYRPREKR-- 76

                          90       100       110
                  ....*....|....*....|....*....|
gi 755566863  308 RDRSSQYARDRSSQYARdRSSQYARDRSPQ 337
Cdd:TIGR01622  77 RRRGDSYRRRRDDRRSR-REKPRARDGTPE 105
Fibrinogen_BP pfam08017
Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family ...
 213-421 1.12e-05

Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family includes the fibrinogen receptor, FbsA, which mediates platelet aggregation.


Pssm-ID: 311808 [Multi-domain]  Cd Length: 393  Bit Score: 48.32  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  213 DRSSHYARDRSPHYARDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPQYARDRSPHYARDRSPQYARDRSSQYAR 292
Cdd:pfam08017  88 NRSQGNVLERRQRDAENRSQGNVLERRQRDAENKSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAE 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  293 DRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSPQYARDRSSHYARDRSPHYARDRSPHYARDRSPHYAR 372
Cdd:pfam08017 168 NRSQGNVLERRQRDAENKSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAE 247

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 755566863  373 DRSSHYARDRSPQYARDRSSQYARDRSSHYARDRSSHYARDRspHKRDA 421
Cdd:pfam08017 248 NKSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLER--RQRDA 294
Fibrinogen_BP pfam08017
Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family ...
 213-415 2.04e-05

Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family includes the fibrinogen receptor, FbsA, which mediates platelet aggregation.


Pssm-ID: 311808 [Multi-domain]  Cd Length: 393  Bit Score: 47.17  E-value: 2.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  213 DRSSHYARDRSPHYARDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPQYARDRSPHYARDRSPQYARDRSSQYAR 292
Cdd:pfam08017  64 ERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENKSQGNVLERRQRDAENRSQGNVL 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  293 DRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSPQYARDRSSHYARDRSPHYARDRSPHYARDRSPHYAR 372
Cdd:pfam08017 144 ERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENKSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVL 223

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 755566863  373 DRSSHYARDRSPQYARDRSSQYARDRSSHYARDRSSHYARDRS 415
Cdd:pfam08017 224 ERRQRDAENRSQGNVLERRQRDAENKSQGNVLERRQRDAENRS 266
Fibrinogen_BP pfam08017
Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family ...
 213-415 2.04e-05

Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family includes the fibrinogen receptor, FbsA, which mediates platelet aggregation.


Pssm-ID: 311808 [Multi-domain]  Cd Length: 393  Bit Score: 47.17  E-value: 2.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  213 DRSSHYARDRSPHYARDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPQYARDRSPHYARDRSPQYARDRSSQYAR 292
Cdd:pfam08017  96 ERRQRDAENRSQGNVLERRQRDAENKSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVL 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  293 DRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSPQYARDRSSHYARDRSPHYARDRSPHYARDRSPHYAR 372
Cdd:pfam08017 176 ERRQRDAENKSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENKSQGNVL 255

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 755566863  373 DRSSHYARDRSPQYARDRSSQYARDRSSHYARDRSSHYARDRS 415
Cdd:pfam08017 256 ERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENKS 298
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 212-334 5.02e-05

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 46.45  E-value: 5.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  212 RDRSSHYARDRSPHYARDRSPHYARDRppqyARDRSSQyaRDRSpqyaRDRSPQYARDRSPHyaRDRSPQYARDRSSQYA 291
Cdd:TIGR01622   3 RDRERERLRDSSSAGDRDRRRDKGRER----SRDRSRD--RERS----RSRRRDRHRDRDYY--RGRERRSRSRRPNRRY 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 755566863  292 RDRSSQYARDRSSQYAR-DRSSQYARDRSSQYARDRSSQYARDR 334
Cdd:TIGR01622  71 RPREKRRRRGDSYRRRRdDRRSRREKPRARDGTPEPLTEDERDR 114
Fibrinogen_BP pfam08017
Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family ...
 213-421 6.17e-05

Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family includes the fibrinogen receptor, FbsA, which mediates platelet aggregation.


Pssm-ID: 311808 [Multi-domain]  Cd Length: 393  Bit Score: 45.63  E-value: 6.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  213 DRSSHYARDRSPHYARDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPQYARDRSPHYARDRSPQYARDRSSQYAR 292
Cdd:pfam08017  56 NRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENKSQGNVLERRQRDAE 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  293 DRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSPQYARDRSSHYARDRSPHYARDRSPHYARDRSPHYAR 372
Cdd:pfam08017 136 NRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENKSQGNVLERRQRDAENRSQGNVLERRQRDAE 215

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 755566863  373 DRSSHYARDRSPQYARDRSSQYARDRSSHYARDRSSHYARDRspHKRDA 421
Cdd:pfam08017 216 NRSQGNVLERRQRDAENRSQGNVLERRQRDAENKSQGNVLER--RQRDA 262
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 340-446 6.85e-05

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 46.04  E-value: 6.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  340 RDRSSHYARDRSPHYARDRSPHYARDRSPHYARDRSSHYARDRSPQYARDRSSQYARDRSShyarDRSSHYARDRSPHKR 419
Cdd:TIGR01642   5 PDREREKSRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDRRRYDSRSPRS----LRYSSVRRSRDRPRR 80

                          90       100
                  ....*....|....*....|....*..
gi 755566863  420 DAPFVRestagwKNSQHNRSGSIISGR 446
Cdd:TIGR01642  81 RSRSVR------SIEQHRRRLRDRSPS 101
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 332-420 8.58e-05

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 45.68  E-value: 8.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  332 RDRSPQYARDRSSHYARDRSPHyaRDRSPHYARDRSPHYARDRSSHYARDRSPQYARDRSSQYARDRSSHYARDRSSHYA 411
Cdd:TIGR01622   1 RYRDRERERLRDSSSAGDRDRR--RDKGRERSRDRSRDRERSRSRRRDRHRDRDYYRGRERRSRSRRPNRRYRPREKRRR 78


                  ....*....
gi 755566863  412 RDRSPHKRD 420
Cdd:TIGR01622  79 RGDSYRRRR 87
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 211-428 1.08e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.55  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  211 PRDRSSHYARDRSP---HYARDRSPHYARDRppqyARDRSSQYARDRSPQYARDRSPQYARDRSPHYARDRSPQYARDRS 287
Cdd:PHA03307  198 PPAAASPRPPRRSSpisASASSPAPAPGRSA----ADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEAS 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  288 SQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSPQyardrSSHYARDRSPHYARDRSPHYARDRS 367
Cdd:PHA03307  274 GWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRE-----SSSSSTSSSSESSRGAAVSPGPSPS 348

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755566863  368 PHYARDRSSHyARDRSPQYARDRSSQYARDRSSHYARD--RSSHYARDRSPHKRDAPFVREST 428
Cdd:PHA03307  349 RSPSPSRPPP-PADPSSPRKRPRPSRAPSSPAASAGRPtrRRARAAVAGRARRRDATGRFPAG 410
Fibrinogen_BP pfam08017
Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family ...
 213-415 1.36e-04

Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family includes the fibrinogen receptor, FbsA, which mediates platelet aggregation.


Pssm-ID: 311808 [Multi-domain]  Cd Length: 393  Bit Score: 44.86  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  213 DRSSHYARDRSPHYARDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPQYARDRSPHYARDRSPQYARDRSSQYAR 292
Cdd:pfam08017  32 ERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVL 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  293 DRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSPQYARDRSSHYARDRSPHYARDRSPHYARDRSPHYAR 372
Cdd:pfam08017 112 ERRQRDAENKSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENKSQGNVL 191

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 755566863  373 DRSSHYARDRSPQYARDRSSQYARDRSSHYARDRSSHYARDRS 415
Cdd:pfam08017 192 ERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENRS 234
Fibrinogen_BP pfam08017
Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family ...
 213-415 1.36e-04

Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family includes the fibrinogen receptor, FbsA, which mediates platelet aggregation.


Pssm-ID: 311808 [Multi-domain]  Cd Length: 393  Bit Score: 44.86  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  213 DRSSHYARDRSPHYARDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPQYARDRSPHYARDRSPQYARDRSSQYAR 292
Cdd:pfam08017  48 ERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENKSQGNVL 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  293 DRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSPQYARDRSSHYARDRSPHYARDRSPHYARDRSPHYAR 372
Cdd:pfam08017 128 ERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENKSQGNVLERRQRDAENRSQGNVL 207

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 755566863  373 DRSSHYARDRSPQYARDRSSQYARDRSSHYARDRSSHYARDRS 415
Cdd:pfam08017 208 ERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENKS 250
Fibrinogen_BP pfam08017
Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family ...
 213-421 1.76e-04

Fibrinogen binding protein; Proteins in this family bind to fibrinogen. Members of this family includes the fibrinogen receptor, FbsA, which mediates platelet aggregation.


Pssm-ID: 311808 [Multi-domain]  Cd Length: 393  Bit Score: 44.47  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  213 DRSSHYARDRSPHYARDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPQYARDRSPHYARDRSPQYARDRSSQYAR 292
Cdd:pfam08017  40 NRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAE 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  293 DRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSPQYARDRSSHYARDRSPHYARDRSPHYARDRSPHYAR 372
Cdd:pfam08017 120 NKSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLERRQRDAENKSQGNVLERRQRDAE 199

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 755566863  373 DRSSHYARDRSPQYARDRSSQYARDRSSHYARDRSSHYARDRspHKRDA 421
Cdd:pfam08017 200 NRSQGNVLERRQRDAENRSQGNVLERRQRDAENRSQGNVLER--RQRDA 246
SF-CC1 TIGR01622
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ...
 268-368 1.76e-04

splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.


Pssm-ID: 273721 [Multi-domain]  Cd Length: 494  Bit Score: 44.52  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  268 RDRSPHYARDRSPQYARDRSSQyaRDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSPQYARDRSSHYA 347
Cdd:TIGR01622   1 RYRDRERERLRDSSSAGDRDRR--RDKGRERSRDRSRDRERSRSRRRDRHRDRDYYRGRERRSRSRRPNRRYRPREKRRR 78

                          90       100
                  ....*....|....*....|....*.
gi 755566863  348 RDRSPHYARD-----RSPHYARDRSP 368
Cdd:TIGR01622  79 RGDSYRRRRDdrrsrREKPRARDGTP 104
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 211-318 2.63e-04

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 44.11  E-value: 2.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  211 PRDRSSHYARDRSPHYARDRSPHYARDRPPQYARDRSSQYARDRSPQyaRDRSPQYARDRSPHYARDRSPQYARDRSSQy 290
Cdd:TIGR01642  12 SRGRDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRPRDRRRY--DSRSPRSLRYSSVRRSRDRPRRRSRSVRSI- 88

                          90       100
                  ....*....|....*....|....*...
gi 755566863  291 ARDRSSQYARDRSSQYARDRSSQYARDR 318
Cdd:TIGR01642  89 EQHRRRLRDRSPSNQWRKDDKKRSLWDI 116
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 70-384 5.20e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 43.24  E-value: 5.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863   70 PKRPPLLDKIPPQVVN-VPKRPPLLDKIPPRVVNVPKKPPLLDKIPPQVVNVPKKPPLLDKIPPQVVNVPKKPPPLFDNI 148
Cdd:PHA03307  117 PPPTPPPASPPPSPAPdLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPS 196

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  149 PPLLARPGDGY--YSHDAFRVCDEGQSFFRDQRRSRRNYHSASWQPNYRNRRGGLRRKTFSSHHprdrsshyARDRSPHY 226
Cdd:PHA03307  197 TPPAAASPRPPrrSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRP--------APITLPTR 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  227 ARDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPqyARDRSPHYARDRSPqyarDRSSQYARDRSSQyarDRSSQY 306
Cdd:PHA03307  269 IWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSG--PAPSSPRASSSSSS----SRESSSSSTSSSS---ESSRGA 339

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755566863  307 ARDRSSQYARDRSSQYARDRSsqyarDRSPQYARDRSSHYARDRSPHYARDRSPHYARDRSPHY-ARDRSSHYARDRSP 384
Cdd:PHA03307  340 AVSPGPSPSRSPSPSRPPPPA-----DPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRArRRDATGRFPAGRPR 413
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 195-398 6.76e-04

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 42.97  E-value: 6.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863 195 RNRRGGLRRKTFSSHHPRDRSSHYARDRSPHYARDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPQYARDRSPHY 274
Cdd:PRK12678  77 ARRAARAAAAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERGEAARRGAARKAGEGGEQPATEA 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863 275 ARDRSPQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSPQYARDRSSHYARDRSPHY 354
Cdd:PRK12678 157 RADAAERTEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDRRDRREQGDRREERGRRDGGDRRGRRRRRDRR 236

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 755566863 355 ARDRSphyARDRSPHYARDRSSHYARDRSPQYARDRSSQYARDR 398
Cdd:PRK12678 237 DARGD---DNREDRGDRDGDDGEGRGGRRGRRFRDRDRRGRRGG 277
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 211-426 1.47e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 41.81  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863 211 PRDRSSHYARDRSPHYARDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPQYARDRSPHYARDRSPQYARDRSSQY 290
Cdd:PRK12678  77 ARRAARAAAAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERGEAARRGAARKAGEGGEQPATEA 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863 291 ARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSPQYARDRSSHYARDRSPHYARDRSPHYARDRSPHY 370
Cdd:PRK12678 157 RADAAERTEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDRRDRREQGDRREERGRRDGGDRRGRRRRRDRR 236

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755566863 371 ARDRSSHYARDRSPQYARDRSSQYARDRSSHYARDRsshyaRDRSphkRDAPFVRE 426
Cdd:PRK12678 237 DARGDDNREDRGDRDGDDGEGRGGRRGRRFRDRDRR-----GRRG---GDGGNERE 284
RSRP pfam17069
Arginine/Serine-Rich protein 1; RSRP1 is an eukaryotic protein family. Its function is unknown.
 254-404 1.75e-03

Arginine/Serine-Rich protein 1; RSRP1 is an eukaryotic protein family. Its function is unknown.


Pssm-ID: 293674 [Multi-domain]  Cd Length: 299  Bit Score: 40.91  E-value: 1.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  254 RSPQYARDRSPQYARDRSPHYARDRSPQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSsqyaRD 333
Cdd:pfam17069  17 KSPSTSSSGSSSRLSSRSRSRSSSRSSRSHSRSSSRFSSRSRSRPRRSRSRSRSRRRHQRKYRRYSRSYSRSRS----RS 92

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755566863  334 RSPQYARDRSSHYARD--RSPHYARDRSPHYARDRSpHYARDRSSHYARDRSPQYARDRSSQYARDRSSHYAR 404
Cdd:pfam17069  93 RRRRYYRRSRYRYSRRyyRSPSRSRSRSRSRSRGRS-YYAIWRGSRYYGFGRTVYPERSPRWRSRSRTRSRSR 164
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 195-414 1.99e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 41.43  E-value: 1.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863 195 RNRRGGlrrktfSSHHPRDRSSHYARDRSPHYARDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPQYARDRSPHY 274
Cdd:PRK12678  56 KEARGG------GAAAAAATPAAPAAAARRAARAAAAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARE 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863 275 ARDRSPQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDR-SSQYARDRSPQYARDRSSHYARDRSPH 353
Cdd:PRK12678 130 RRERGEAARRGAARKAGEGGEQPATEARADAAERTEEEERDERRRRGDREDRqAEAERGERGRREERGRDGDDRDRRDRR 209

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755566863 354 YARDRSPHYA-RDRSPHYARDRSSHYARDRSPQYARDRSSQYARDRssHYARDRSSHYARDR 414
Cdd:PRK12678 210 EQGDRREERGrRDGGDRRGRRRRRDRRDARGDDNREDRGDRDGDDG--EGRGGRRGRRFRDR 269
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 176-280 2.40e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 41.03  E-value: 2.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  176 RDQRRSRRNYHSaSWQPNYRNRRGGLRRKTFSSHHpRDRSSHyaRDRSPHYARDRSPHYARDRPPQYARDRSSQyARDRS 255
Cdd:TIGR01642  19 RSSERPRRRSRD-RSRFRDRHRRSRERSYREDSRP-RDRRRY--DSRSPRSLRYSSVRRSRDRPRRRSRSVRSI-EQHRR 93

                          90       100
                  ....*....|....*....|....*
gi 755566863  256 PQYARDRSPQYARDRSPHYARDRSP 280
Cdd:TIGR01642  94 RLRDRSPSNQWRKDDKKRSLWDIKP 118
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 219-420 2.53e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 41.04  E-value: 2.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863 219 ARDRSPHYARDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPQYARDRSPHYARDRSPQYARDRSSQYARDRSSQY 298
Cdd:PRK12678  58 ARGGGAAAAAATPAAPAAAARRAARAAAAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERGEAA 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863 299 ARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSPQYARDRSSHYARDRSPHYARDRSPHYARDRsphyARDRSSHY 378
Cdd:PRK12678 138 RRGAARKAGEGGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDDRDR----RDRREQGD 213

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 755566863 379 ARDRSPQyaRDRSSQYARDRSSHYARDRSSHYARDRSPHKRD 420
Cdd:PRK12678 214 RREERGR--RDGGDRRGRRRRRDRRDARGDDNREDRGDRDGD 253
U2AF_lg TIGR01642
U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of ...
 202-316 3.44e-03

U2 snRNP auxilliary factor, large subunit, splicing factor; These splicing factors consist of an N-terminal arginine-rich low complexity domain followed by three tandem RNA recognition motifs (pfam00076). The well-characterized members of this family are auxilliary components of the U2 small nuclear ribonuclearprotein splicing factor (U2AF). These proteins are closely related to the CC1-like subfamily of splicing factors (TIGR01622). Members of this subfamily are found in plants, metazoa and fungi.


Pssm-ID: 273727 [Multi-domain]  Cd Length: 509  Bit Score: 40.26  E-value: 3.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863  202 RRKTFSSHHPRDRSSHYARDRSPHYARDRSPHYARDRPpqyaRDRSSQyaRDRSPQYARDRSPQYARDrsphyaRDRSPQ 281
Cdd:TIGR01642  15 RDRDRSSERPRRRSRDRSRFRDRHRRSRERSYREDSRP----RDRRRY--DSRSPRSLRYSSVRRSRD------RPRRRS 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 755566863  282 YARDRSSQYaRDRSSQYARDRSSQYARDRSSQYAR 316
Cdd:TIGR01642  83 RSVRSIEQH-RRRLRDRSPSNQWRKDDKKRSLWDI 116
PRK12678 PRK12678
transcription termination factor Rho; Provisional
 219-420 5.96e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 39.89  E-value: 5.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863 219 ARDRSPHYARDRSPHYARDRPPQYARDRSSQYARDRSPQYARDRSPQYARDRSPHYARDRSPQYARDRSSQYARDRSSQY 298
Cdd:PRK12678  68 ATPAAPAAAARRAARAAAAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERGEAARRGAARKAGE 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863 299 ARDRSSQYARDRSSQYARDRSSQYARDRSSQYARDRSPQyARDRSSHYARDRSPHYARDRSPHYARDRSPHYARDRSSHY 378
Cdd:PRK12678 148 GGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAE-RGERGRREERGRDGDDRDRRDRREQGDRREERGRRDGGDR 226

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 755566863 379 ARDRSPQYARDRSSQYARDRSSHYARDRSSHYARDRSPHKRD 420
Cdd:PRK12678 227 RGRRRRRDRRDARGDDNREDRGDRDGDDGEGRGGRRGRRFRD 268
PHA03118 PHA03118
multifunctional expression regulator; Provisional
 325-419 9.39e-03

multifunctional expression regulator; Provisional


Pssm-ID: 165391  Cd Length: 474  Bit Score: 38.90  E-value: 9.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755566863 325 DRSSQYARDRSPQYARDRSSHYARDRSPHYARDRSPHYA-RDRSPHYARDRSSHyarDRSPQYARDRSSQYARDRSSHYA 403
Cdd:PHA03118  78 DRAYTNPNFEKKAHGRREGYHHDDEKCLVTFLDDINHHGgRDTEPGHAHIENGE---RKSPKSYNQQSRKKHRDESLRNK 154

                         90
                 ....*....|....*.
gi 755566863 404 RDRSSHYArDRSPHKR 419
Cdd:PHA03118 155 HGRPSGPP-AMSPGEH 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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