NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|755559138|ref|XP_011244958|]
View 

sulfotransferase 6B1 isoform X1 [Mus musculus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
5-184 1.18e-54

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 174.07  E-value: 1.18e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559138    5 PSPRILTTHLHYDKLPQSIFKNKAKILVIFRNPKDTAVSFFHFHNDVPDIPSYASWDEFFRQFIKGQVSWGSYFDFAINW 84
Cdd:pfam00685  70 PSPRIIKTHLPLHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGW 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559138   85 NKHIDDENVKFILYEDLKENLVVGIKQISEFLGFSLTDEQIETISTQSTFLAMRANSQETHGAI----GPFlFRKGEVGD 160
Cdd:pfam00685 150 WKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLpkevSPF-FRKGLVGD 228

                         170       180
                  ....*....|....*....|....
gi 755559138  161 WKRLFNETQNQEMDERFKECLAGT 184
Cdd:pfam00685 229 WKNYFTPEQAEKFDEIYQEKMKGT 252
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
5-184 1.18e-54

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 174.07  E-value: 1.18e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559138    5 PSPRILTTHLHYDKLPQSIFKNKAKILVIFRNPKDTAVSFFHFHNDVPDIPSYASWDEFFRQFIKGQVSWGSYFDFAINW 84
Cdd:pfam00685  70 PSPRIIKTHLPLHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGW 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559138   85 NKHIDDENVKFILYEDLKENLVVGIKQISEFLGFSLTDEQIETISTQSTFLAMRANSQETHGAI----GPFlFRKGEVGD 160
Cdd:pfam00685 150 WKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLpkevSPF-FRKGLVGD 228

                         170       180
                  ....*....|....*....|....
gi 755559138  161 WKRLFNETQNQEMDERFKECLAGT 184
Cdd:pfam00685 229 WKNYFTPEQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 9-186 8.36e-19

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 82.66  E-value: 8.36e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559138   9 ILTTHLHYDKLPQSIFKNKAKILVIFRNPKDTAVSFFHF-HNDVPDIPSYASWDEFFRQFIKGQVSWGSYFDFAIN-WNK 86
Cdd:PLN02164 147 LFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGyWKA 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559138  87 HIDDEN-VKFILYEDLKENLVVGIKQISEFLGFSLTDEQIE--------TISTQSTFLAMRANSQETHGAIGPFL----- 152
Cdd:PLN02164 227 YQENPDrILFLKYETMRADPLPYVKRLAEFMGYGFTAEEEEkgvvekvvKLCSFETLKNLEANKGEKDREDRPAVyansa 306

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 755559138 153 -FRKGEVGDWKRLFNETQNQEMDERFKECLAGTSL 186
Cdd:PLN02164 307 yFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
5-184 1.18e-54

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 174.07  E-value: 1.18e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559138    5 PSPRILTTHLHYDKLPQSIFKNKAKILVIFRNPKDTAVSFFHFHNDVPDIPSYASWDEFFRQFIKGQVSWGSYFDFAINW 84
Cdd:pfam00685  70 PSPRIIKTHLPLHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGW 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559138   85 NKHIDDENVKFILYEDLKENLVVGIKQISEFLGFSLTDEQIETISTQSTFLAMRANSQETHGAI----GPFlFRKGEVGD 160
Cdd:pfam00685 150 WKLRPPGNILFLRYEDLKKDPRGEIKKIAEFLGIPLTEEELDKIVKHLSFENMKGNPCLNYSKLpkevSPF-FRKGLVGD 228

                         170       180
                  ....*....|....*....|....
gi 755559138  161 WKRLFNETQNQEMDERFKECLAGT 184
Cdd:pfam00685 229 WKNYFTPEQAEKFDEIYQEKMKGT 252
PLN02164 PLN02164
sulfotransferase
 9-186 8.36e-19

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 82.66  E-value: 8.36e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559138   9 ILTTHLHYDKLPQSIFKNKAKILVIFRNPKDTAVSFFHF-HNDVPDIPSYASWDEFFRQFIKGQVSWGSYFDFAIN-WNK 86
Cdd:PLN02164 147 LFSTHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGyWKA 226

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559138  87 HIDDEN-VKFILYEDLKENLVVGIKQISEFLGFSLTDEQIE--------TISTQSTFLAMRANSQETHGAIGPFL----- 152
Cdd:PLN02164 227 YQENPDrILFLKYETMRADPLPYVKRLAEFMGYGFTAEEEEkgvvekvvKLCSFETLKNLEANKGEKDREDRPAVyansa 306

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 755559138 153 -FRKGEVGDWKRLFNETQNQEMDERFKECLAGTSL 186
Cdd:PLN02164 307 yFRKGKVGDWQNYLTPEMAARIDGLMEEKFKGTGL 341
Sulfotransfer_3 pfam13469
Sulfotransferase family;
28-122 2.27e-05

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 43.05  E-value: 2.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755559138   28 AKILVIFRNPKDTAVS----FFHFHNdvpdipsyASWDEFFRQFIKGQVS-W-GSYFDFAINWNKhIDDENVKFILYEDL 101
Cdd:pfam13469  82 AKFIHLHRDPVDTVISsycsLFGFTL--------SSYSTAFLRDIGLALArWsRAYERLMAARAR-VPPGRFLDVRYEDL 152

                          90       100
                  ....*....|....*....|.
gi 755559138  102 KENLVVGIKQISEFLGFSLTD 122
Cdd:pfam13469 153 VADPEGTLRRILEFLGLPWDD 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH