BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  14 GEIDHVHILSEHIGALLIGEEYGDVTFVVEKKHFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLR 93
Cdd:cd18287    1 GEIDHVHFLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQ-QSEIELKDTNAEAFKALLK 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 755556437  94 YIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYL 133
Cdd:cd18287   80 YIYTGRLTLTDLKEDVLLDVLGLAHQYGFEELEAAISDYL 119

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  466 NALLNGDTKNYdWdsgytcHQLGSGA---IVVQLAQPYIIGSIRLLLW--DCDDRSYSYYVEVSTNQQQWTMVADRTKVS 540
Cdd:pfam00754  15 AAALDGDPNTA-W------SAWSGDDpqwIQVDLGKPKKITGVVTQGRqdGSNGYVTSYKIEYSLDGENWTTVKDEKIPG 87

                          90       100       110
                  ....*....|....*....|....*....|..
gi 755556437  541 C---KSWQSVTFErQP--ASFIRIVGTHNTAN 567
Cdd:pfam00754  88 NndnNTPVTNTFD-PPikARYVRIVPTSWNGG 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  14 GEIDHVHILSEHIGALLIGEEYGDVTFVVEKKHFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLR 93
Cdd:cd18287    1 GEIDHVHFLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQ-QSEIELKDTNAEAFKALLK 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 755556437  94 YIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYL 133
Cdd:cd18287   80 YIYTGRLTLTDLKEDVLLDVLGLAHQYGFEELEAAISDYL 119

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437   33 EEYGDVTFVVEKKHFPAHRVILAARCQYFRALLYGGMRESqPEAEIPLQDTTAEAFTMLLRYIYTGRAtltdEKEEVLLD 112
Cdd:pfam00651   8 GELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESES-SVSEITLDDVSPEDFEALLEFMYTGKL----ISEENVDD 82

                          90       100
                  ....*....|....*....|....*
gi 755556437  113 FLSLAHKYGFPELEDSTSEYLCTIL 137
Cdd:pfam00651  83 LLAAADKLQIPSLVDKCEEFLIKSL 107

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437    37 DVTFVVEKKHFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLRYIYTGRATLTDEKeevLLDFLSL 116
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESD-KSEIYLDDVSPEDFRALLNFLYTGKLDLPEEN---VEELLEL 76

                           90       100
                   ....*....|....*....|.
gi 755556437   117 AHKYGFPELEDSTSEYLCTIL 137
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKLL 97

kelch-like protein; Provisional

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  38 VTFVVEKKHFPAHRVILAARCQYFRALLYGGMRESqpeaEIPLQDTTaEAFTMLLRYIYTGRATLTDEKEEvllDFLSLA 117
Cdd:PHA03098  14 IIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKEN----EINLNIDY-DSFNEVIKYIYTGKINITSNNVK---DILSIA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437 118 HKYGFPELEDSTSEYLCTILNIQNVCMTFDVASLYSLPKLTCMCCMFMDRNAQEVLASDGFLSLSKTALLNIvLRDS--F 195
Cdd:PHA03098  86 NYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKI-LSDDklN 164

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755556437 196 AAPEKDIFLALLNWCKHNAKENHAEImqavrlplmslTELLNVVRPSgLLSPDAI 250
Cdd:PHA03098 165 VSSEDVVLEIIIKWLTSKKNNKYKDI-----------CLILKVLRIT-FLSEEGI 207

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  14 GEIDHVHILSEHIGALLIGEEYGDVTFVVEKKHFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLR 93
Cdd:cd18287    1 GEIDHVHFLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQ-QSEIELKDTNAEAFKALLK 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 755556437  94 YIYTGRATLTDEKEEVLLDFLSLAHKYGFPELEDSTSEYL 133
Cdd:cd18287   80 YIYTGRLTLTDLKEDVLLDVLGLAHQYGFEELEAAISDYL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  37 DVTFVVEKKHFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLRYIYTGRATLTdekEEVLLDFLSL 116
Cdd:cd18186    3 DVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESS-SSEIELDDVSPEAFEALLDYIYTGELELS---EENVEELLAA 78

                 ....
gi 755556437 117 AHKY 120
Cdd:cd18186   79 ADKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  22 LSEHIGALLIGEEYGDVTFVV--EKKHFPAHRVILAARCQYFRALLYGGMRESQPEAEIPLQDTTAEAFTMLLRYIYTGR 99
Cdd:cd18294    1 FAADMKSLINNPEFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLVLSDIEPEVFRAVLEFIYTNC 80

                         90       100       110
                 ....*....|....*....|....*....|....
gi 755556437 100 ATLTDekeEVLLDFLSLAHKYGFPELEDSTSEYL 133
Cdd:cd18294   81 VTLSN---HTVIEVLAAAVEYGLDELRKLCERFI 111

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437    37 DVTFVVEKKHFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLRYIYTGRATLTDEKeevLLDFLSL 116
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESD-KSEIYLDDVSPEDFRALLNFLYTGKLDLPEEN---VEELLEL 76

                           90       100
                   ....*....|....*....|.
gi 755556437   117 AHKYGFPELEDSTSEYLCTIL 137
Cdd:smart00225  77 ADYLQIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  33 EEYGDVTFVVEKKHFPAHRVILAARCQYFRALLYGGMRE-SQPEAEIPlqDTTAEAFTMLLRYIYTGRATLTDEKEEVLL 111
Cdd:cd18297   10 PEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEaQTPVIEIP--DIRYDIFQLMMQYLYTGGVESLDVAQDDAL 87

                         90       100
                 ....*....|....*....|...
gi 755556437 112 DFLSLAHKYGFPELEDSTsEYLC 134
Cdd:cd18297   88 ELLRAASFFQLDGLKRHC-EILL 109

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  33 EEYGDVTFVVEKKHFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLRYIYTGRATLTDEKEEVllD 112
Cdd:cd18300    7 GLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESS-AKEVELPGVSKETFLALLEYLYTDQAPILEDGDCV--G 83

                         90
                 ....*....|...
gi 755556437 113 FLSLAHKYGFPEL 125
Cdd:cd18300   84 LIVLANRLCLPRL 96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  22 LSEHIGALLIGEEYGDVTFVVEKKHFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLRYIYtgrat 101
Cdd:cd18280    1 LGQHFGALLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREEN-EGEIVIEDVEPPVFKALLHFIY----- 74

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437 102 lTDEKEEVLldflslahkygfpELEDSTSEYLCTILnIQNVcmtFDVASLYSLPKLTCMC 161
Cdd:cd18280   75 -KDELPDDV-------------EPAGSDSSSLDTTM-AQHL---LAAADRYALERLRLLC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  22 LSEHIGALLIGEEYGDVTFVVEKKHFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLRYIYTGRAT 101
Cdd:cd18345    5 LSDDLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERK-QNRVEITDVDHEVMREMLRFIYTGKAP 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 755556437 102 LTDEKEEvllDFLSLAHKYGFPELEDSTSEYLCTILNIQNV 142
Cdd:cd18345   84 NLDKMAD---DLLAAADKYALERLKVMCEEALCSNLSVENV 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  33 EEYGDVTFVVEKKHFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLRYIYTGRATLTDEKEEVLLD 112
Cdd:cd18237   19 KTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESK-SSEVELKDAEPDIIELLVEFAYTARISVNSNNVQSLLD 97

                         90       100
                 ....*....|....*....|....*....
gi 755556437 113 flsLAHKYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18237   98 ---AANQYQIEPVKKMCVDFLKEQLDASN 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  37 DVTFVVEKKHFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLRYIYTGRATLTDEKEEVLLDFLSL 116
Cdd:cd18238   17 DVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESK-QDSITIKDIDEEAVELLVDFAYTGKLTLTVDNVQSLLYAASL 95

                         90       100
                 ....*....|....*....|....*
gi 755556437 117 ahkYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18238   96 ---LQVEEVAKACCEFMKDHLHPSN 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  37 DVTFVVEKKHFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLRYIYTGRATLT-DEKEEVLldfLS 115
Cdd:cd18255   20 DVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESS-QDEIELKGVSAKGLKHILDFAYTSELTLDlDCIQDVL---GA 95

                         90       100
                 ....*....|....*....|....*.
gi 755556437 116 LAHKYGFPELEdSTSEYLCTILNIQN 141
Cdd:cd18255   96 AVHLQMLPVVE-LCEEFLKSAMSVEN 120

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  31 IGEEYGDVTFVVEKKHFPAHRVILAARCQYFRALLYGGMRESQPE-AEIP---LQDTTAEAFTMLLRYIYTGRATLTDek 106
Cdd:cd18296   13 QELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEENnGSIPvvtLHDVSPEVFAIVLYYIYTDDTDLPP-- 90

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 755556437 107 eEVLLDFLSLAHKYGFPELEDstseyLCTILNIQNVC 143
Cdd:cd18296   91 -ENAYDVLYVADMYLLPGLKR-----LCGTVLAQSLD 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  37 DVTFVV----EKKHFPAHRVILAARCQYFRALLYGGMRESQPEAEIPlqDTTAEAFTMLLRYIYTGRATLTdekEEVLLD 112
Cdd:cd18282    9 DVHFIVgppgGTQRIPAHKYVLATGSSVFYAMFYGGLAENKNEIEIP--DVEPAAFLNLLRYLYCDEIDLE---PDTVLA 83

                         90       100
                 ....*....|....*....|....*
gi 755556437 113 FLSLAHKYGFPELEDSTSEYLCTIL 137
Cdd:cd18282   84 TLYAAKKYLVPHLARACVQFLETSL 108

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  22 LSEHIGALLIGEEYGDVTFVV--EKKHFPAHRVILAARCQYFR------------------------ALLYGGMRESQPE 75
Cdd:cd18308   10 LHDDFGRLLESRQFCDVEFIVgeEEERIPAHIAFVAARSKWLRnkilqarerqkqkaeqevedegseADSSSASKNDSPM 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755556437  76 AEIPLQDTTAEAFTMLLRYIYTGRATLTDEKEE------VLL--DFLSLAHKYGFPELEDSTSEYL 133
Cdd:cd18308   90 LEVRLPEADPEAFELILSFIYTDKIDPTRKGQDpgsnevVLLmmDVYRLALQFQMSRLEQLCVQYL 155

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  22 LSEHIGALLIGEEYGDVTFVVEKKHFPAHRVILAARCQYFRALLyggmreSQPEAEIPLQDTTAEAFTMLLRYIYTGRAT 101
Cdd:cd18303    5 LLKTVASLFDKELYSDITIKLADKSIPAHKFVLAARSEKWSNEN------LASTNELDLSDISYEVVLALLRWLYTDELD 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 755556437 102 LTDEkEEVLLDFLSLAHKYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18303   79 LTLD-DEFLLELMKAAKRFQLTDLVERCERALMSSVNVDN 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  24 EHIGALLIGEEYGDVTFVVEKKHFPAHRVILAARCQYFRALLY--GGMRESQPEAEIPLQDTTAEAFTMLLRYIYTGRAT 101
Cdd:cd18292    6 QDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSndWWSESKQSEIELVEDPECAAVFEKFLRYLYTGQIS 85

                         90       100       110
                 ....*....|....*....|....*....|.
gi 755556437 102 LTdekEEVLLDFLSLAHKYGFPELEDSTSEY 132
Cdd:cd18292   86 VN---LETALPLLMLADKYNVTDLKQLCVDF 113

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  31 IGEEYGDVTFVVEKKHFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDT--TAEAFTMLLRYIYTGRATLTDEKee 108
Cdd:cd18309   16 VGGDFCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPEDN-TVNISIGEMvpSRQAFDSLLRYIYYGDVTMPPED-- 92

                         90
                 ....*....|....
gi 755556437 109 vLLDFLSLAHKYGF 122
Cdd:cd18309   93 -SLYLFSAPYFYGF 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  22 LSEHIGALLIGEEYGDVTFVVEK----KHFPAHRVILAARCQYFRALLYGGMRESQPEAEIPlqDTTAEAFTMLLRYIYt 97
Cdd:cd18281    9 VKERFAFLFNNETLSDVHFIVGKgdneQRIPAHKFVLSIGSAVFDAMFNGGMATTSAEIELP--DVEPAAFLALLRFLY- 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 755556437  98 gratlTDEKE---EVLLDFLSLAHKYGFPELEDSTSEYLCTILNIQN 141
Cdd:cd18281   86 -----SDEVQigpETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  24 EHIGALLIGEEYGDVTFVVEKKH-FPAHRVILAARCQYFRALLyGGMRESQPEAEIplqdtTAEAFTMLLRYIYTGRAtl 102
Cdd:cd18299    1 EDLRNLLHSPSCADVVFILQGGVrIFAHRIVLAAASSVFADLF-LMMTVVTLDSDI-----TPEAFRRVLEFLYTGVL-- 72

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 755556437 103 tDEKEEVLLDFLSLAHKYGFPELEDStseylctILNIQN 141
Cdd:cd18299   73 -DENEDDLKELKDAAELLELFDLVMM-------CTNVLN 103

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  31 IGEEY------GDVTFVVEKKHFPAHRVILAARCQYFRALLYGGMRESQPEaEIPLQDTTAEAFTMLLRYIYTGRATLTD 104
Cdd:cd18352    3 LGEQYvnnatlSDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEAR-DIEIPNIRWEVFELMMRFIYTGSVDITN 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 755556437 105 EKEEvllDFLSLAHKY---GFPEL-EDSTSEYLCT 135
Cdd:cd18352   82 DIAK---DLLRAADQYlleGLKRLcEYTIAQDLTL 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755556437  37 DVTFVVE----KKHFPAHRVILAARCQYFRALLYGGMRESQPEaEIPLQDTTAEAFTMLLRYIYTGRATLTD 104
Cdd:cd18248   23 DVTLKVKyqdpKEEFMAHKVVLASSSPYFKAMFTSGLRECGME-VVPIEGVHPCVMSRLIEFAYTASISVGE 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556437  45 KHFPAHRVILAARCQYFRALLYGGMRESQpEAEIPLQDTTAEAFTMLLRYIYTGRATLTDEKEEVLLDFLSLahkYGFPE 124
Cdd:cd18274   33 KTFSCHRNVLAAISPYFRSMFTSGLTEST-QKEVRIVGVEAESMHLVLDYAYTSRVTLTEANVQALFTAASI---FQIPS 108

                         90
                 ....*....|....*..
gi 755556437 125 LEDSTSEYLCTILNIQN 141
Cdd:cd18274  109 LQDQCAQFMISRLDPQN 125