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Conserved domains on  [gi|755551237|ref|XP_011243824|]
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fibrocystin-L isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2184-2302 3.68e-41

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


:

Pssm-ID: 462971  Cd Length: 121  Bit Score: 148.52  E-value: 3.68e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  2184 SWGGSPPPEEGSLAVITKGQIILLDQSTPILKMLLIQGgTLIF-DEANIELQAENILITdGGVLQIGTEASPFQHRAVIT 2262
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQG-TLIFdDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 755551237  2263 LHG--HLRSPELPVYGAKTLGVRE-GTLDLHGLPIPVVWTRLT 2302
Cdd:pfam10162   79 LHGrpELDDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWTKLA 121
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 3043-3171 8.97e-38

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


:

Pssm-ID: 462971  Cd Length: 121  Bit Score: 138.89  E-value: 8.97e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  3043 NNYTVPRPGANVIIPEGTWIVADVDIPPVERLIIWGVLEMEDKSEIgvagptyrrvVLNATYISVQGGRLIGGWEDNPFK 3122
Cdd:pfam10162    3 GGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDDKNI----------TLRARYILVQGGRLIIGSEDCPFQ 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 755551237  3123 GELQIVLRGNhstPEWAFPDGPNQGAKVLGV--FGELDLHGLPHSVYKTKL 3171
Cdd:pfam10162   73 GKATITLHGR---PELDDDDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKL 120
Cupredoxin super family cl19115
Cupredoxin superfamily; Cupredoxins contain type I copper centers and are involved in ...
 1394-1497 6.46e-32

Cupredoxin superfamily; Cupredoxins contain type I copper centers and are involved in inter-molecular electron transfer reactions. Cupredoxins are blue copper proteins, having an intense blue color due to the presence of a mononuclear type 1 (T1) copper site. Structurally, the cupredoxin-like fold consists of a beta-sandwich with 7 strands in 2 beta-sheets, which is arranged in a Greek-key beta-barrel. Some of these proteins have lost the ability to bind copper. The majority of family members contain multiple cupredoxin domain repeats: ceruloplasmin and the coagulation factors V/VIII have six repeats; laccase, ascorbate oxidase, spore coat protein A, and multicopper oxidase CueO contain three repeats; and nitrite reductase has two repeats. Others are mono-domain cupredoxins, such as plastocyanin, pseudoazurin, plantacyanin, azurin, rusticyanin, stellacyanin, quinol oxidase, and the periplasmic domain of cytochrome c oxidase subunit II.


The actual alignment was detected with superfamily member cd04217:

Pssm-ID: 473140 [Multi-domain]  Cd Length: 86  Bit Score: 120.74  E-value: 6.46e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1394 TNNGSHLVHGLGYAWSPSVLNVTVGDTVVWSWQAHPflrgiGYRIFSVSSPGSVTYDdkgftngrQKSASGSFSYQFTSP 1473
Cdd:cd04217     1 TNAGKDLVRGLGYVISPSELEINVGDTVTWHNFKRP-----KGRIVLVSEEGLFEDQ--------TLYYGKAFSYTFTEP 67

                          90       100
                  ....*....|....*....|....
gi 755551237 1474 GIYYYSSGYVDEahsisLQGVINV 1497
Cdd:cd04217    68 GTYYFSVKDVPE-----MKGTINV 86
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 270-363 5.97e-19

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 84.04  E-value: 5.97e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  270 PEVVMVSPSKGSTEGGTLLTIHGHFFDQTDLPVRVLVGGQACAILNVTENTIYCKTPPKPHILKATYPggrgLKVEVWNN 349
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVE----VTVDGANV 76

                          90
                  ....*....|....
gi 755551237  350 SRPAHLEDILEYNE 363
Cdd:cd00603    77 SARVLSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 2090-2175 1.46e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.89  E-value: 1.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 2090 PLITEISPRRGSTAGGTRLTVTGSGFSENTQGVQVFVGNSKCDIQYSNKTHIVCMTSVHVPSGWVPVHVNIKNIGLAKLE 2169
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVEVTVDGANVSARV 80


                  ....*...
gi 755551237 2170 NAD--FLY 2175
Cdd:cd00603    81 LSNttFTY 88
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1658-1744 7.17e-17

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 78.27  E-value: 7.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1658 PNIDMVMPKAGSTTGMTRVTIQGSGFMSSPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQ---QLVLVDILIHGVPAQC 1734
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATpgeGPVEVTVDGANVSARV 80

                          90
                  ....*....|
gi 755551237 1735 QSNCSFSYLE 1744
Cdd:cd00603    81 LSNTTFTYVE 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1830-1909 1.22e-16

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 77.10  E-value: 1.22e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  1830 PAVASVSPTSGSIAGGTTLMITGNGFSPG--NTTVTVGDQPCQITFISSSEVYCSTPAGRAGTANLKISVN--AIIYPPL 1905
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDssDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGggGISSSPL 80


                   ....
gi 755551237  1906 SFTY 1909
Cdd:pfam01833   81 TFTY 84
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1240-1314 3.63e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 73.26  E-value: 3.63e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755551237 1240 PVVTDFSPKERTVLGKVNLTIKGYNFGNELAQNTVYVGRKHCQVLHSNFTDITCLLPTLP-PGKHDIYVKVRNWGL 1314
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtPGEGPVEVTVDGANV 76
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1157-1234 1.62e-13

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 68.64  E-value: 1.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1157 ISHVWPDSGSLAGGTLLTISGFGF---SENSTVLVGNETCNVIEGDLNRITCRTSKRIEG-----TVDISVITNGIQVTA 1228
Cdd:cd00603     3 ITSISPSSGPLSGGTRLTITGSNLgsgSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPgegpvEVTVDGANVSARVLS 82


                  ....*.
gi 755551237 1229 KDSFSY 1234
Cdd:cd00603    83 NTTFTY 88
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1999-2085 8.84e-13

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 66.32  E-value: 8.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1999 SIQNIYPTQGSFGGGQTLTVTGMGFDP--WNSTILVCNSECAVdkLRSNSTTLFCVIPPNNGKGHDQV-CGVSVVNGKDS 2075
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSgsPRVRVTVGGVPCKV--LNVSSTEIVCRTPAAATPGEGPVeVTVDGANVSAR 79

                          90
                  ....*....|
gi 755551237 2076 SHSTKLFTYT 2085
Cdd:cd00603    80 VLSNTTFTYV 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1915-1996 7.13e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 63.62  E-value: 7.13e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  1915 PFLKRIIPNRGLP--GTEVEITGSNLGFAISDVSVMIKESVCNVTTVNDTVLQCTVGEHAGGIFPVTMLHKTKGSAVSSV 1992
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   ....
gi 755551237  1993 AFEY 1996
Cdd:pfam01833   81 TFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1748-1828 1.56e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 62.85  E-value: 1.56e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  1748 PYVTGIFPNS--IQGYGNVLIKGERFGTVLEEISIFIGSQQFRVIDVNENNITVLMTPLEAGLHSLSVVVGSKGLALGNL 1825
Cdd:pfam01833    1 PVITSISPSSgpASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   ...
gi 755551237  1826 TIS 1828
Cdd:pfam01833   81 TFT 83
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1565-1647 1.68e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.77  E-value: 1.68e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  1565 PSIINITPSTGTAN--ELITIIGHGFSSLPCANKVTIGSYPCVVEESSENSIICHIDPQNSMNVGIreIVTLIVYNLGTA 1642
Cdd:pfam01833    1 PVITSISPSSGPASggTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNV--SVTVGGGGISSS 78


                   ....*
gi 755551237  1643 INTLT 1647
Cdd:pfam01833   79 PLTFT 83
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 31-126 7.17e-10

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


:

Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 58.23  E-value: 7.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   31 PKVTEVIPKYGSINGATRLTIKGEGFSQASqfnygadntelgnhVQLVSSFQSITCDVEkdSSHSTQITCYTRAMPE-DT 109
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGS--------------PRVRVTVGGVPCKVL--NVSSTEIVCRTPAAATpGE 64

                          90
                  ....*....|....*..
gi 755551237  110 YSVRVSVDGVPVAENNT 126
Cdd:cd00603    65 GPVEVTVDGANVSARVL 81
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1335-1405 2.80e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 56.30  E-value: 2.80e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755551237  1335 FPQRGSLYGGTEITIMGFGFSTIPTENSVLLGSFPCDITSSSENVIKCTL--HSTGTV-FRITNNGSHLVHGLG 1405
Cdd:pfam01833    7 SPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTppGTSGLVnVSVTVGGGGISSSPL 80
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1067-1143 2.73e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 53.60  E-value: 2.73e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755551237  1067 PLILTTTPSEGSYAESTILTIAGSGFSPTS-AVSVSVGSTRCSLLSVEENEIKCQILNGSAGHVPVAVSIADVGLAQN 1143
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
PA14 super family cl08459
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 363-467 7.92e-07

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


The actual alignment was detected with superfamily member pfam07691:

Pssm-ID: 471833 [Multi-domain]  Cd Length: 141  Bit Score: 51.21  E-value: 7.92e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   363 EHTPGYMGATW-TDSASYvwPIEQDTFVARISGFLVPPDSDVYRFYIRGDDRYAIYFSqtgrteDKVRIAYysgNANTYF 441
Cdd:pfam07691   22 IDTDPDNTFYWdTDVPGF--GEAPGDFSARWTGYLLPPESGTYTFGVASDDGARLWID------GELVIDN---WGQHPP 90

                           90       100
                   ....*....|....*....|....*.
gi 755551237   442 SNSTQRSDEIHLQKGKEYYIEILLQE 467
Cdd:pfam07691   91 DASPEESNTLYLVAGKLYPIRIEYFH 116
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 146-255 2.79e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 45.13  E-value: 2.79e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   146 PTIRSITPLSGTP--GTLITIKGRLFtdvygsntalssnGRNVRILRIYIGGMPCELlIPHSDDlyglkldhangdtgSV 223
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNF-------------GTDSSDLKVTIGGTPCTV-ISVSST--------------TI 52

                           90       100       110
                   ....*....|....*....|....*....|..
gi 755551237   224 TCKTTGTYIGHHNVSFILDSDYGRSFPEKMTY 255
Cdd:pfam01833   53 VCTTPPGTSGLVNVSVTVGGGGISSSPLTFTY 84
 
Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2184-2302 3.68e-41

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 148.52  E-value: 3.68e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  2184 SWGGSPPPEEGSLAVITKGQIILLDQSTPILKMLLIQGgTLIF-DEANIELQAENILITdGGVLQIGTEASPFQHRAVIT 2262
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQG-TLIFdDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 755551237  2263 LHG--HLRSPELPVYGAKTLGVRE-GTLDLHGLPIPVVWTRLT 2302
Cdd:pfam10162   79 LHGrpELDDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWTKLA 121
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 3043-3171 8.97e-38

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 138.89  E-value: 8.97e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  3043 NNYTVPRPGANVIIPEGTWIVADVDIPPVERLIIWGVLEMEDKSEIgvagptyrrvVLNATYISVQGGRLIGGWEDNPFK 3122
Cdd:pfam10162    3 GGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDDKNI----------TLRARYILVQGGRLIIGSEDCPFQ 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 755551237  3123 GELQIVLRGNhstPEWAFPDGPNQGAKVLGV--FGELDLHGLPHSVYKTKL 3171
Cdd:pfam10162   73 GKATITLHGR---PELDDDDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKL 120
Cupredoxin_Fibrocystin-L_like cd04217
Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease ...
 1394-1497 6.46e-32

Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease protein; One member of this family is Fibrocystin-L, a homolog of the autosomal recessive polycystic kidney disease protein PKHD1. Human fibrocystin-L is predicted to be a large receptor protein (466 kDa) with a signal peptide, a single transmembrane domain and a short cytoplasmic tail. Fibrocystin-L is widely expressed at a low level in most tissues but is up-regulated specifically in T lymphocytes following activation signals. It may play roles in immunity.


Pssm-ID: 259879 [Multi-domain]  Cd Length: 86  Bit Score: 120.74  E-value: 6.46e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1394 TNNGSHLVHGLGYAWSPSVLNVTVGDTVVWSWQAHPflrgiGYRIFSVSSPGSVTYDdkgftngrQKSASGSFSYQFTSP 1473
Cdd:cd04217     1 TNAGKDLVRGLGYVISPSELEINVGDTVTWHNFKRP-----KGRIVLVSEEGLFEDQ--------TLYYGKAFSYTFTEP 67

                          90       100
                  ....*....|....*....|....
gi 755551237 1474 GIYYYSSGYVDEahsisLQGVINV 1497
Cdd:cd04217    68 GTYYFSVKDVPE-----MKGTINV 86
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 270-363 5.97e-19

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 84.04  E-value: 5.97e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  270 PEVVMVSPSKGSTEGGTLLTIHGHFFDQTDLPVRVLVGGQACAILNVTENTIYCKTPPKPHILKATYPggrgLKVEVWNN 349
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVE----VTVDGANV 76

                          90
                  ....*....|....
gi 755551237  350 SRPAHLEDILEYNE 363
Cdd:cd00603    77 SARVLSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 2090-2175 1.46e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.89  E-value: 1.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 2090 PLITEISPRRGSTAGGTRLTVTGSGFSENTQGVQVFVGNSKCDIQYSNKTHIVCMTSVHVPSGWVPVHVNIKNIGLAKLE 2169
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVEVTVDGANVSARV 80


                  ....*...
gi 755551237 2170 NAD--FLY 2175
Cdd:cd00603    81 LSNttFTY 88
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1658-1744 7.17e-17

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 78.27  E-value: 7.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1658 PNIDMVMPKAGSTTGMTRVTIQGSGFMSSPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQ---QLVLVDILIHGVPAQC 1734
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATpgeGPVEVTVDGANVSARV 80

                          90
                  ....*....|
gi 755551237 1735 QSNCSFSYLE 1744
Cdd:cd00603    81 LSNTTFTYVE 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1830-1909 1.22e-16

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 77.10  E-value: 1.22e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  1830 PAVASVSPTSGSIAGGTTLMITGNGFSPG--NTTVTVGDQPCQITFISSSEVYCSTPAGRAGTANLKISVN--AIIYPPL 1905
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDssDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGggGISSSPL 80


                   ....
gi 755551237  1906 SFTY 1909
Cdd:pfam01833   81 TFTY 84
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1830-1909 1.01e-15

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 74.57  E-value: 1.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1830 PAVASVSPTSGSIAGGTTLMITGNGFSPGNTT-VTVGDQPCQITFISSSEVYCSTPAGRA-GTANLKISV-NAIIYPPLS 1906
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVrVTVGGQPCKILSVSSSQIVCLTPPSASpGEAPVKVLIdGARRLAPLV 80


                  ...
gi 755551237 1907 FTY 1909
Cdd:cd01179    81 FTY 83
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1240-1314 3.63e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 73.26  E-value: 3.63e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755551237 1240 PVVTDFSPKERTVLGKVNLTIKGYNFGNELAQNTVYVGRKHCQVLHSNFTDITCLLPTLP-PGKHDIYVKVRNWGL 1314
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtPGEGPVEVTVDGANV 76
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 2090-2165 1.18e-14

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 71.71  E-value: 1.18e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755551237  2090 PLITEISPRRGSTAGGTRLTVTGSGFSENTQGVQVFVGNSKCDIQYSNKTHIVCMTSVHVPsGWVPVHVNIKNIGL 2165
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTS-GLVNVSVTVGGGGI 75
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1157-1234 1.62e-13

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 68.64  E-value: 1.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1157 ISHVWPDSGSLAGGTLLTISGFGF---SENSTVLVGNETCNVIEGDLNRITCRTSKRIEG-----TVDISVITNGIQVTA 1228
Cdd:cd00603     3 ITSISPSSGPLSGGTRLTITGSNLgsgSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPgegpvEVTVDGANVSARVLS 82


                  ....*.
gi 755551237 1229 KDSFSY 1234
Cdd:cd00603    83 NTTFTY 88
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1999-2085 8.84e-13

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 66.32  E-value: 8.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1999 SIQNIYPTQGSFGGGQTLTVTGMGFDP--WNSTILVCNSECAVdkLRSNSTTLFCVIPPNNGKGHDQV-CGVSVVNGKDS 2075
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSgsPRVRVTVGGVPCKV--LNVSSTEIVCRTPAAATPGEGPVeVTVDGANVSAR 79

                          90
                  ....*....|
gi 755551237 2076 SHSTKLFTYT 2085
Cdd:cd00603    80 VLSNTTFTYV 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1915-1996 7.13e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 63.62  E-value: 7.13e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  1915 PFLKRIIPNRGLP--GTEVEITGSNLGFAISDVSVMIKESVCNVTTVNDTVLQCTVGEHAGGIFPVTMLHKTKGSAVSSV 1992
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   ....
gi 755551237  1993 AFEY 1996
Cdd:pfam01833   81 TFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1658-1742 7.64e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 63.62  E-value: 7.64e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  1658 PNIDMVMPKAGSTTGMTRVTIQGSGFMSSPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQQLVLVDILIHGVpAQCQSN 1737
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGG-GISSSP 79


                   ....*
gi 755551237  1738 CSFSY 1742
Cdd:pfam01833   80 LTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1998-2084 1.28e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 62.85  E-value: 1.28e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  1998 LSIQNIYPTQGSFGGGQTLTVTGMGF--DPWNSTILVCNSECAVdkLRSNSTTLFCVIPPNNGKGHdqvcGVSV-VNGKD 2074
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFgtDSSDLKVTIGGTPCTV--ISVSSTTIVCTTPPGTSGLV----NVSVtVGGGG 74

                           90
                   ....*....|
gi 755551237  2075 SSHSTKLFTY 2084
Cdd:pfam01833   75 ISSSPLTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1748-1828 1.56e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 62.85  E-value: 1.56e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  1748 PYVTGIFPNS--IQGYGNVLIKGERFGTVLEEISIFIGSQQFRVIDVNENNITVLMTPLEAGLHSLSVVVGSKGLALGNL 1825
Cdd:pfam01833    1 PVITSISPSSgpASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   ...
gi 755551237  1826 TIS 1828
Cdd:pfam01833   81 TFT 83
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 270-346 5.81e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 60.92  E-value: 5.81e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755551237   270 PEVVMVSPSKGSTEGGTLLTIHGHFFDQTDLPVRVLVGGQACAILNVTENTIYCKTPPKPhilkatyPGGRGLKVEV 346
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGT-------SGLVNVSVTV 70
IPT smart00429
ig-like, plexins, transcription factors;
270-337 8.59e-11

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 60.90  E-value: 8.59e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755551237    270 PEVVMVSPSKGSTEGGTLLTIHGHFFDQ-TDLPVRVLVGGQACAILNVTENTIYCKTPPKpHILKATYP 337
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSiSVVFVEVGVGEAPCTFSPSSSTAIVCKTPPY-HNIPGSVP 69
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1565-1647 1.68e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.77  E-value: 1.68e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  1565 PSIINITPSTGTAN--ELITIIGHGFSSLPCANKVTIGSYPCVVEESSENSIICHIDPQNSMNVGIreIVTLIVYNLGTA 1642
Cdd:pfam01833    1 PVITSISPSSGPASggTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNV--SVTVGGGGISSS 78


                   ....*
gi 755551237  1643 INTLT 1647
Cdd:pfam01833   79 PLTFT 83
IPT smart00429
ig-like, plexins, transcription factors;
1830-1909 5.12e-10

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 58.59  E-value: 5.12e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   1830 PAVASVSPTSGSIAGGTTLMITGNGFSPGNT---TVTVGDQPCQITFISSSEVYCSTPAGRAGTANLKISVNAII----- 1901
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVvfvEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLRnggvp 81


                    ....*...
gi 755551237   1902 YPPLSFTY 1909
Cdd:smart00429   82 SSPQPFTY 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 31-126 7.17e-10

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 58.23  E-value: 7.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   31 PKVTEVIPKYGSINGATRLTIKGEGFSQASqfnygadntelgnhVQLVSSFQSITCDVEkdSSHSTQITCYTRAMPE-DT 109
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGS--------------PRVRVTVGGVPCKVL--NVSSTEIVCRTPAAATpGE 64

                          90
                  ....*....|....*..
gi 755551237  110 YSVRVSVDGVPVAENNT 126
Cdd:cd00603    65 GPVEVTVDGANVSARVL 81
IPT smart00429
ig-like, plexins, transcription factors;
2090-2175 2.41e-09

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 56.66  E-value: 2.41e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   2090 PLITEISPRRGSTAGGTRLTVTGSGF-SENTQGVQVFVGNSKCDIQYSNKTHIVCMT-SVHVPSGWVPVHVNIKNIGLAK 2167
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLkSISVVFVEVGVGEAPCTFSPSSSTAIVCKTpPYHNIPGSVPVRTVGLRNGGVP 81


                    ....*...
gi 755551237   2168 LENADFLY 2175
Cdd:smart00429   82 SSPQPFTY 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1156-1234 2.61e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 56.30  E-value: 2.61e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  1156 QISHVWPDSGSLAGGTLLTISGFGF---SENSTVLVGNETCNVIEGDLNRITCRTSKRIEGTVDISVITNGIQ-VTAKDS 1231
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGiSSSPLT 81


                   ...
gi 755551237  1232 FSY 1234
Cdd:pfam01833   82 FTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1335-1405 2.80e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 56.30  E-value: 2.80e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755551237  1335 FPQRGSLYGGTEITIMGFGFSTIPTENSVLLGSFPCDITSSSENVIKCTL--HSTGTV-FRITNNGSHLVHGLG 1405
Cdd:pfam01833    7 SPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTppGTSGLVnVSVTVGGGGISSSPL 80
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1915-1996 4.99e-09

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 55.92  E-value: 4.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1915 PFLKRIIPNRGLP--GTEVEITGSNLGFAISDVSVMIKESVCNVTTVNDTVLQCTVGEHA-GGIFPVTMLHKTKG---SA 1988
Cdd:cd00603     1 PVITSISPSSGPLsgGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtPGEGPVEVTVDGANvsaRV 80


                  ....*...
gi 755551237 1989 VSSVAFEY 1996
Cdd:cd00603    81 LSNTTFTY 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1067-1143 2.73e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 53.60  E-value: 2.73e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755551237  1067 PLILTTTPSEGSYAESTILTIAGSGFSPTS-AVSVSVGSTRCSLLSVEENEIKCQILNGSAGHVPVAVSIADVGLAQN 1143
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1240-1317 7.03e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 52.45  E-value: 7.03e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755551237  1240 PVVTDFSPKERTVLGKVNLTIKGYNFGNELAQNTVYVGRKHCQVLHSNFTDITCLLPTLPPGKHDIYVKVRNWGLAST 1317
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1067-1154 8.54e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 52.46  E-value: 8.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1067 PLILTTTPSEGSYAESTILTIAGSGFSPTSA-VSVSVGSTRCSLLSVEENEIKCQIL-NGSAGHVPVAVSIaDVGLAQNL 1144
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrVRVTVGGVPCKVLNVSSTEIVCRTPaAATPGEGPVEVTV-DGANVSAR 79

                          90
                  ....*....|
gi 755551237 1145 EGEGSHFIYR 1154
Cdd:cd00603    80 VLSNTTFTYV 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1331-1384 9.33e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 52.07  E-value: 9.33e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 755551237 1331 VIHMF-PQRGSLYGGTEITIMGFGFSTIPTENSVLLGSFPCDITSSSENVIKCTL 1384
Cdd:cd00603     2 VITSIsPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRT 56
PA14 pfam07691
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 363-467 7.92e-07

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


Pssm-ID: 400161 [Multi-domain]  Cd Length: 141  Bit Score: 51.21  E-value: 7.92e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   363 EHTPGYMGATW-TDSASYvwPIEQDTFVARISGFLVPPDSDVYRFYIRGDDRYAIYFSqtgrteDKVRIAYysgNANTYF 441
Cdd:pfam07691   22 IDTDPDNTFYWdTDVPGF--GEAPGDFSARWTGYLLPPESGTYTFGVASDDGARLWID------GELVIDN---WGQHPP 90

                           90       100
                   ....*....|....*....|....*.
gi 755551237   442 SNSTQRSDEIHLQKGKEYYIEILLQE 467
Cdd:pfam07691   91 DASPEESNTLYLVAGKLYPIRIEYFH 116
PA14 smart00758
domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, ...
 341-467 9.72e-07

domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins;


Pssm-ID: 214807 [Multi-domain]  Cd Length: 136  Bit Score: 50.86  E-value: 9.72e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237    341 GLKVEVWNNSRPAHLEDIleynEHTPGYMGATW-TDSASYvwPIEQDTFVARISGFLVPPDSDVYRFYIRGDDRYAIYFS 419
Cdd:smart00758    2 GLTGYYFENEKFSGLPEI----IDTDPLNTFYWdSDKFGE--GEKADNFSVRWTGYLKPPEDGEYTFSITSDDGARLWID 75

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*...
gi 755551237    420 qtgrteDKVRIayysgNANTYFSNSTQRSDEIHLQKGKEYYIEILLQE 467
Cdd:smart00758   76 ------GKLVI-----DNWGKHEARPSTSSTLYLLAGGTYPIRIEYFE 112
IPT smart00429
ig-like, plexins, transcription factors;
1997-2085 6.88e-06

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 47.03  E-value: 6.88e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   1997 PLSIQNIYPTQGSFGGGQTLTVTGMGFDPWNS---TILVCNSECAVdkLRSNSTTLFCVIPPNNGKGHDQ-VCGVSVVNG 2072
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVvfvEVGVGEAPCTF--SPSSSTAIVCKTPPYHNIPGSVpVRTVGLRNG 78

                            90
                    ....*....|...
gi 755551237   2073 kDSSHSTKLFTYT 2085
Cdd:smart00429   79 -GVPSSPQPFTYV 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 31-126 1.11e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 46.29  E-value: 1.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237    31 PKVTEVIPKYGSINGATRLTIKGEGFSQASqfnygaDNTELgnhvqlvsSFQSITCDVEKDSshSTQITCYTRAMPEDTY 110
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDS------SDLKV--------TIGGTPCTVISVS--STTIVCTTPPGTSGLV 64

                           90
                   ....*....|....*.
gi 755551237   111 SVRVSVDGVPVAENNT 126
Cdd:pfam01833   65 NVSVTVGGGGISSSPL 80
IPT smart00429
ig-like, plexins, transcription factors;
1657-1743 2.60e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 45.10  E-value: 2.60e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   1657 LPNIDMVMPKAGSTTGMTRVTIQGSGFMS-SPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQQLVL-----VDILIHGV 1730
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSiSVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSvpvrtVGLRNGGV 80

                            90
                    ....*....|...
gi 755551237   1731 PAQCQsncSFSYL 1743
Cdd:smart00429   81 PSSPQ---PFTYV 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 146-255 2.79e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 45.13  E-value: 2.79e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   146 PTIRSITPLSGTP--GTLITIKGRLFtdvygsntalssnGRNVRILRIYIGGMPCELlIPHSDDlyglkldhangdtgSV 223
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNF-------------GTDSSDLKVTIGGTPCTV-ISVSST--------------TI 52

                           90       100       110
                   ....*....|....*....|....*....|..
gi 755551237   224 TCKTTGTYIGHHNVSFILDSDYGRSFPEKMTY 255
Cdd:pfam01833   53 VCTTPPGTSGLVNVSVTVGGGGISSSPLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
1067-1154 2.86e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 45.10  E-value: 2.86e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   1067 PLILTTTPSEGSYAESTILTIAGSGFSPTSAVSVSV--GSTRCSLLSVEENEIKCQILNGSAGHVPVAVSIADVGLAqNL 1144
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVgvGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLRNG-GV 80

                            90
                    ....*....|
gi 755551237   1145 EGEGSHFIYR 1154
Cdd:smart00429   81 PSSPQPFTYV 90
PetE COG3794
Plastocyanin [Energy production and conversion];
1406-1478 3.13e-05

Plastocyanin [Energy production and conversion];


Pssm-ID: 443008 [Multi-domain]  Cd Length: 76  Bit Score: 44.60  E-value: 3.13e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755551237 1406 YAWSPSVLNVTVGDTVVWSWQAhpflrGIGYRIFSVSSPgsvtydDKGFTNGRQKsASGSFSYQFTSPGIYYY 1478
Cdd:COG3794     1 MAFEPATLTVKPGDTVTWVNTD-----SVPHNVTSDDGP------DGAFDSGLLA-PGETFSVTFDEPGTYDY 61
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1565-1623 4.78e-05

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 44.37  E-value: 4.78e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755551237 1565 PSIINITPSTGTANE--LITIIGHGFSSLPCANKVTIGSYPCVVEESSENSIICHIDPQNS 1623
Cdd:cd00603     1 PVITSISPSSGPLSGgtRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAT 61
IPT smart00429
ig-like, plexins, transcription factors;
1157-1234 1.38e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 43.18  E-value: 1.38e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   1157 ISHVWPDSGSLAGGTLLTISGFGF----SENSTVLVGNETCNVIEGDLNRITCRTSKRIEGTVDISVITNGIQ---VTAK 1229
Cdd:smart00429    4 ITRISPTSGPVSGGTEITLCGKNLksisVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLRnggVPSS 83


                    ....*.
gi 755551237   1230 DS-FSY 1234
Cdd:smart00429   84 PQpFTY 89
IPT smart00429
ig-like, plexins, transcription factors;
31-119 5.16e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 41.64  E-value: 5.16e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237     31 PKVTEVIPKYGSINGATRLTIKGEGFSQASQFNYGADNTElgnhvqlvssfqsITCDVekDSSHSTQITCYTRAMPEDTY 110
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGE-------------APCTF--SPSSSTAIVCKTPPYHNIPG 66


                    ....*....
gi 755551237    111 SVRVSVDGV 119
Cdd:smart00429   67 SVPVRTVGL 75
IPT smart00429
ig-like, plexins, transcription factors;
1331-1384 9.27e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.87  E-value: 9.27e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 755551237   1331 VIH-MFPQRGSLYGGTEITIMGFGFSTIPTEN-SVLLGSFPCDITSSSENVIKCTL 1384
Cdd:smart00429    3 VITrISPTSGPVSGGTEITLCGKNLKSISVVFvEVGVGEAPCTFSPSSSTAIVCKT 58
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 146-244 1.09e-03

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 40.52  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  146 PTIRSITPLSGTP--GTLITIKGRLFtdvygsntalssnGRNVRILRIYIGGMPCELLiphsddlyglkldhaNGDTGSV 223
Cdd:cd00603     1 PVITSISPSSGPLsgGTRLTITGSNL-------------GSGSPRVRVTVGGVPCKVL---------------NVSSTEI 52

                          90       100
                  ....*....|....*....|..
gi 755551237  224 TCKT-TGTYIGHHNVSFILDSD 244
Cdd:cd00603    53 VCRTpAAATPGEGPVEVTVDGA 74
IPT smart00429
ig-like, plexins, transcription factors;
1919-1996 1.11e-03

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.48  E-value: 1.11e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   1919 RIIPNRGLP--GTEVEITGSNLGfAISDVSVMIK--ESVCNVTTVNDTVLQCTVGEHAGGIFPV---TMLHKTKGSAVSS 1991
Cdd:smart00429    6 RISPTSGPVsgGTEITLCGKNLK-SISVVFVEVGvgEAPCTFSPSSSTAIVCKTPPYHNIPGSVpvrTVGLRNGGVPSSP 84


                    ....*
gi 755551237   1992 VAFEY 1996
Cdd:smart00429   85 QPFTY 89
 
Name Accession Description Interval E-value
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 2184-2302 3.68e-41

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 148.52  E-value: 3.68e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  2184 SWGGSPPPEEGSLAVITKGQIILLDQSTPILKMLLIQGgTLIF-DEANIELQAENILITdGGVLQIGTEASPFQHRAVIT 2262
Cdd:pfam10162    1 TWGGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQG-TLIFdDDKNITLRARYILVQ-GGRLIIGSEDCPFQGKATIT 78

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 755551237  2263 LHG--HLRSPELPVYGAKTLGVRE-GTLDLHGLPIPVVWTRLT 2302
Cdd:pfam10162   79 LHGrpELDDDDGPNYGSKVIGVRNgGTLELHGQPPTVTWTKLA 121
G8 pfam10162
G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after ...
 3043-3171 8.97e-38

G8 domain; This domain is found in disease proteins PKHD1 and KIAA1199 and is named G8 after its 8 conserved glycines. It is predicted to contain 10 beta strands and an alpha helix.


Pssm-ID: 462971  Cd Length: 121  Bit Score: 138.89  E-value: 8.97e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  3043 NNYTVPRPGANVIIPEGTWIVADVDIPPVERLIIWGVLEMEDKSEIgvagptyrrvVLNATYISVQGGRLIGGWEDNPFK 3122
Cdd:pfam10162    3 GGGVVPQPGDNVVIPAGQTVLLDVSSPTLKSLVIQGTLIFDDDKNI----------TLRARYILVQGGRLIIGSEDCPFQ 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 755551237  3123 GELQIVLRGNhstPEWAFPDGPNQGAKVLGV--FGELDLHGLPHSVYKTKL 3171
Cdd:pfam10162   73 GKATITLHGR---PELDDDDGPNYGSKVIGVrnGGTLELHGQPPTVTWTKL 120
Cupredoxin_Fibrocystin-L_like cd04217
Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease ...
 1394-1497 6.46e-32

Cupredoxin domain of PKHDL1, a homolog of the autosomal recessive polycystic kidney disease protein; One member of this family is Fibrocystin-L, a homolog of the autosomal recessive polycystic kidney disease protein PKHD1. Human fibrocystin-L is predicted to be a large receptor protein (466 kDa) with a signal peptide, a single transmembrane domain and a short cytoplasmic tail. Fibrocystin-L is widely expressed at a low level in most tissues but is up-regulated specifically in T lymphocytes following activation signals. It may play roles in immunity.


Pssm-ID: 259879 [Multi-domain]  Cd Length: 86  Bit Score: 120.74  E-value: 6.46e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1394 TNNGSHLVHGLGYAWSPSVLNVTVGDTVVWSWQAHPflrgiGYRIFSVSSPGSVTYDdkgftngrQKSASGSFSYQFTSP 1473
Cdd:cd04217     1 TNAGKDLVRGLGYVISPSELEINVGDTVTWHNFKRP-----KGRIVLVSEEGLFEDQ--------TLYYGKAFSYTFTEP 67

                          90       100
                  ....*....|....*....|....
gi 755551237 1474 GIYYYSSGYVDEahsisLQGVINV 1497
Cdd:cd04217    68 GTYYFSVKDVPE-----MKGTINV 86
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 270-363 5.97e-19

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 84.04  E-value: 5.97e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  270 PEVVMVSPSKGSTEGGTLLTIHGHFFDQTDLPVRVLVGGQACAILNVTENTIYCKTPPKPHILKATYPggrgLKVEVWNN 349
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVE----VTVDGANV 76

                          90
                  ....*....|....
gi 755551237  350 SRPAHLEDILEYNE 363
Cdd:cd00603    77 SARVLSNTTFTYVE 90
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 2090-2175 1.46e-18

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 82.89  E-value: 1.46e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 2090 PLITEISPRRGSTAGGTRLTVTGSGFSENTQGVQVFVGNSKCDIQYSNKTHIVCMTSVHVPSGWVPVHVNIKNIGLAKLE 2169
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPGEGPVEVTVDGANVSARV 80


                  ....*...
gi 755551237 2170 NAD--FLY 2175
Cdd:cd00603    81 LSNttFTY 88
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1658-1744 7.17e-17

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 78.27  E-value: 7.17e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1658 PNIDMVMPKAGSTTGMTRVTIQGSGFMSSPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQ---QLVLVDILIHGVPAQC 1734
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATpgeGPVEVTVDGANVSARV 80

                          90
                  ....*....|
gi 755551237 1735 QSNCSFSYLE 1744
Cdd:cd00603    81 LSNTTFTYVE 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1830-1909 1.22e-16

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 77.10  E-value: 1.22e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  1830 PAVASVSPTSGSIAGGTTLMITGNGFSPG--NTTVTVGDQPCQITFISSSEVYCSTPAGRAGTANLKISVN--AIIYPPL 1905
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDssDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGggGISSSPL 80


                   ....
gi 755551237  1906 SFTY 1909
Cdd:pfam01833   81 TFTY 84
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 2090-2175 8.55e-16

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 75.19  E-value: 8.55e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 2090 PLITEISPRRGSTAGGTRLTVTGSGFSENTQGVQVFVGNSKCDIQYSNKTHIVCMTSVHVPSGWVPVHVNIKNIGLAKLE 2169
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGGGVPCSVLSVSSTAIVCTTPPYANPGPGPVEVTVDRGNGGITS 80


                  ....*..
gi 755551237 2170 NA-DFLY 2175
Cdd:cd00102    81 SPlTFTY 87
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1830-1909 1.01e-15

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 74.57  E-value: 1.01e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1830 PAVASVSPTSGSIAGGTTLMITGNGFSPGNTT-VTVGDQPCQITFISSSEVYCSTPAGRA-GTANLKISV-NAIIYPPLS 1906
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVrVTVGGQPCKILSVSSSQIVCLTPPSASpGEAPVKVLIdGARRLAPLV 80


                  ...
gi 755551237 1907 FTY 1909
Cdd:cd01179    81 FTY 83
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1240-1314 3.63e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 73.26  E-value: 3.63e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755551237 1240 PVVTDFSPKERTVLGKVNLTIKGYNFGNELAQNTVYVGRKHCQVLHSNFTDITCLLPTLP-PGKHDIYVKVRNWGL 1314
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtPGEGPVEVTVDGANV 76
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1830-1909 5.11e-15

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 72.87  E-value: 5.11e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1830 PAVASVSPTSGSIAGGTTLMITGNGFSPG--NTTVTVGDQPCQITFISSSEVYCSTPA-GRAGTANLKISVN-----AII 1901
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGspRVRVTVGGVPCKVLNVSSTEIVCRTPAaATPGEGPVEVTVDganvsARV 80


                  ....*...
gi 755551237 1902 YPPLSFTY 1909
Cdd:cd00603    81 LSNTTFTY 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 2090-2165 1.18e-14

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 71.71  E-value: 1.18e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755551237  2090 PLITEISPRRGSTAGGTRLTVTGSGFSENTQGVQVFVGNSKCDIQYSNKTHIVCMTSVHVPsGWVPVHVNIKNIGL 2165
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTS-GLVNVSVTVGGGGI 75
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1157-1234 1.62e-13

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 68.64  E-value: 1.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1157 ISHVWPDSGSLAGGTLLTISGFGF---SENSTVLVGNETCNVIEGDLNRITCRTSKRIEG-----TVDISVITNGIQVTA 1228
Cdd:cd00603     3 ITSISPSSGPLSGGTRLTITGSNLgsgSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAATPgegpvEVTVDGANVSARVLS 82


                  ....*.
gi 755551237 1229 KDSFSY 1234
Cdd:cd00603    83 NTTFTY 88
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1830-1909 4.08e-13

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 67.49  E-value: 4.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1830 PAVASVSPTSGSIAGGTTLMITGNGFSPG-NTTVTV-GDQPCQITFISSSEVYCSTPAGR-AGTANLKISV----NAIIY 1902
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGsNLRVTFgGGVPCSVLSVSSTAIVCTTPPYAnPGPGPVEVTVdrgnGGITS 80


                  ....*..
gi 755551237 1903 PPLSFTY 1909
Cdd:cd00102    81 SPLTFTY 87
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1999-2085 8.84e-13

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 66.32  E-value: 8.84e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1999 SIQNIYPTQGSFGGGQTLTVTGMGFDP--WNSTILVCNSECAVdkLRSNSTTLFCVIPPNNGKGHDQV-CGVSVVNGKDS 2075
Cdd:cd00603     2 VITSISPSSGPLSGGTRLTITGSNLGSgsPRVRVTVGGVPCKV--LNVSSTEIVCRTPAAATPGEGPVeVTVDGANVSAR 79

                          90
                  ....*....|
gi 755551237 2076 SHSTKLFTYT 2085
Cdd:cd00603    80 VLSNTTFTYV 89
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 270-346 2.65e-12

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 65.18  E-value: 2.65e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755551237  270 PEVVMVSPSKGSTEGGTLLTIHGHFFDqTDLPVRVLVGG-QACAILNVTENTIYCKTPPkphilkatYPGGRGLKVEV 346
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFG-SGSNLRVTFGGgVPCSVLSVSSTAIVCTTPP--------YANPGPGPVEV 69
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1658-1744 3.58e-12

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 64.79  E-value: 3.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1658 PNIDMVMPKAGSTTGMTRVTIQGSGFMSSPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQQL-VLVDILIHGVPAQCQS 1736
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGGGVPCSVLSVSSTAIVCTTPPYANPGpGPVEVTVDRGNGGITS 80


                  ....*....
gi 755551237 1737 NC-SFSYLE 1744
Cdd:cd00102    81 SPlTFTYVP 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1915-1996 7.13e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 63.62  E-value: 7.13e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  1915 PFLKRIIPNRGLP--GTEVEITGSNLGFAISDVSVMIKESVCNVTTVNDTVLQCTVGEHAGGIFPVTMLHKTKGSAVSSV 1992
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   ....
gi 755551237  1993 AFEY 1996
Cdd:pfam01833   81 TFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1658-1742 7.64e-12

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 63.62  E-value: 7.64e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  1658 PNIDMVMPKAGSTTGMTRVTIQGSGFMSSPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQQLVLVDILIHGVpAQCQSN 1737
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGG-GISSSP 79


                   ....*
gi 755551237  1738 CSFSY 1742
Cdd:pfam01833   80 LTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1998-2084 1.28e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 62.85  E-value: 1.28e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  1998 LSIQNIYPTQGSFGGGQTLTVTGMGF--DPWNSTILVCNSECAVdkLRSNSTTLFCVIPPNNGKGHdqvcGVSV-VNGKD 2074
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFgtDSSDLKVTIGGTPCTV--ISVSSTTIVCTTPPGTSGLV----NVSVtVGGGG 74

                           90
                   ....*....|
gi 755551237  2075 SSHSTKLFTY 2084
Cdd:pfam01833   75 ISSSPLTFTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1748-1828 1.56e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 62.85  E-value: 1.56e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  1748 PYVTGIFPNS--IQGYGNVLIKGERFGTVLEEISIFIGSQQFRVIDVNENNITVLMTPLEAGLHSLSVVVGSKGLALGNL 1825
Cdd:pfam01833    1 PVITSISPSSgpASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSSPL 80


                   ...
gi 755551237  1826 TIS 1828
Cdd:pfam01833   81 TFT 83
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 2090-2160 2.16e-11

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 62.24  E-value: 2.16e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755551237 2090 PLITEISPRRGSTAGGTRLTVTGSGFSENTQgVQVFVGNSKCDIQYSNKTHIVCMTSVHVPSGWVPVHVNI 2160
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSS-VRVTVGGQPCKILSVSSSQIVCLTPPSASPGEAPVKVLI 70
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1156-1234 4.35e-11

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 61.71  E-value: 4.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1156 QISHVWPDSGSLAGGTLLTISG--FGFSENSTVLV-GNETCNVIEGDLNRITCRTSK---RIEGTVDISVIT-NGIQVTA 1228
Cdd:cd00102     2 VITSISPSSGPVSGGTEVTITGsnFGSGSNLRVTFgGGVPCSVLSVSSTAIVCTTPPyanPGPGPVEVTVDRgNGGITSS 81


                  ....*.
gi 755551237 1229 KDSFSY 1234
Cdd:cd00102    82 PLTFTY 87
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 270-346 5.81e-11

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 60.92  E-value: 5.81e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755551237   270 PEVVMVSPSKGSTEGGTLLTIHGHFFDQTDLPVRVLVGGQACAILNVTENTIYCKTPPKPhilkatyPGGRGLKVEV 346
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGT-------SGLVNVSVTV 70
IPT smart00429
ig-like, plexins, transcription factors;
270-337 8.59e-11

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 60.90  E-value: 8.59e-11
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755551237    270 PEVVMVSPSKGSTEGGTLLTIHGHFFDQ-TDLPVRVLVGGQACAILNVTENTIYCKTPPKpHILKATYP 337
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSiSVVFVEVGVGEAPCTFSPSSSTAIVCKTPPY-HNIPGSVP 69
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1565-1647 1.68e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 59.77  E-value: 1.68e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  1565 PSIINITPSTGTAN--ELITIIGHGFSSLPCANKVTIGSYPCVVEESSENSIICHIDPQNSMNVGIreIVTLIVYNLGTA 1642
Cdd:pfam01833    1 PVITSISPSSGPASggTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNV--SVTVGGGGISSS 78


                   ....*
gi 755551237  1643 INTLT 1647
Cdd:pfam01833   79 PLTFT 83
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 270-363 1.81e-10

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 59.55  E-value: 1.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  270 PEVVMVSPSKGSTEGGTLLTIHGHFFDqTDLPVRVLVGGQACAILNVTENTIYCKTPPKPHILKAtypggrglKVEVWNN 349
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLN-AGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGEA--------PVKVLID 71

                          90
                  ....*....|....
gi 755551237  350 SRPAHLEDILEYNE 363
Cdd:cd01179    72 GARRLAPLVFTYTE 85
IPT smart00429
ig-like, plexins, transcription factors;
1830-1909 5.12e-10

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 58.59  E-value: 5.12e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   1830 PAVASVSPTSGSIAGGTTLMITGNGFSPGNT---TVTVGDQPCQITFISSSEVYCSTPAGRAGTANLKISVNAII----- 1901
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVvfvEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLRnggvp 81


                    ....*...
gi 755551237   1902 YPPLSFTY 1909
Cdd:smart00429   82 SSPQPFTY 89
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 31-126 7.17e-10

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 58.23  E-value: 7.17e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   31 PKVTEVIPKYGSINGATRLTIKGEGFSQASqfnygadntelgnhVQLVSSFQSITCDVEkdSSHSTQITCYTRAMPE-DT 109
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGS--------------PRVRVTVGGVPCKVL--NVSSTEIVCRTPAAATpGE 64

                          90
                  ....*....|....*..
gi 755551237  110 YSVRVSVDGVPVAENNT 126
Cdd:cd00603    65 GPVEVTVDGANVSARVL 81
IPT smart00429
ig-like, plexins, transcription factors;
2090-2175 2.41e-09

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 56.66  E-value: 2.41e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   2090 PLITEISPRRGSTAGGTRLTVTGSGF-SENTQGVQVFVGNSKCDIQYSNKTHIVCMT-SVHVPSGWVPVHVNIKNIGLAK 2167
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLkSISVVFVEVGVGEAPCTFSPSSSTAIVCKTpPYHNIPGSVPVRTVGLRNGGVP 81


                    ....*...
gi 755551237   2168 LENADFLY 2175
Cdd:smart00429   82 SSPQPFTY 89
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1156-1234 2.61e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 56.30  E-value: 2.61e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  1156 QISHVWPDSGSLAGGTLLTISGFGF---SENSTVLVGNETCNVIEGDLNRITCRTSKRIEGTVDISVITNGIQ-VTAKDS 1231
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGiSSSPLT 81


                   ...
gi 755551237  1232 FSY 1234
Cdd:pfam01833   82 FTY 84
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1335-1405 2.80e-09

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 56.30  E-value: 2.80e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755551237  1335 FPQRGSLYGGTEITIMGFGFSTIPTENSVLLGSFPCDITSSSENVIKCTL--HSTGTV-FRITNNGSHLVHGLG 1405
Cdd:pfam01833    7 SPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTppGTSGLVnVSVTVGGGGISSSPL 80
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 2090-2145 4.90e-09

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 55.78  E-value: 4.90e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755551237 2090 PLITEISPRRGSTAGGTRLTVTGS--GFSENTQGVQVFVGNSKCDIQ---YSNKTHIVCMT 2145
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSnlGLRKNDVRHGVRVGGVPCNPEppeYSSSEKIVCTT 61
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1915-1996 4.99e-09

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 55.92  E-value: 4.99e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1915 PFLKRIIPNRGLP--GTEVEITGSNLGFAISDVSVMIKESVCNVTTVNDTVLQCTVGEHA-GGIFPVTMLHKTKG---SA 1988
Cdd:cd00603     1 PVITSISPSSGPLsgGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAtPGEGPVEVTVDGANvsaRV 80


                  ....*...
gi 755551237 1989 VSSVAFEY 1996
Cdd:cd00603    81 LSNTTFTY 88
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1998-2085 7.88e-09

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 55.16  E-value: 7.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1998 LSIQNIYPTQGSFGGGQTLTVTGMGFDP-WNSTILV-CNSECAVdkLRSNSTTLFCVIPPNNGKGHDQVcGVSVVNGKDS 2075
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSgSNLRVTFgGGVPCSV--LSVSSTAIVCTTPPYANPGPGPV-EVTVDRGNGG 77

                          90
                  ....*....|.
gi 755551237 2076 S-HSTKLFTYT 2085
Cdd:cd00102    78 ItSSPLTFTYV 88
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1067-1143 2.73e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 53.60  E-value: 2.73e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755551237  1067 PLILTTTPSEGSYAESTILTIAGSGFSPTS-AVSVSVGSTRCSLLSVEENEIKCQILNGSAGHVPVAVSIADVGLAQN 1143
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSsDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1240-1317 3.31e-08

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 53.62  E-value: 3.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1240 PVVTDFSPKERTVLGKVNLTIKGYNFGNElAQNTVYV-GRKHCQVLHSNFTDITCLLPTLP-PGKHDIYVKVRNWGLAST 1317
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSG-SNLRVTFgGGVPCSVLSVSSTAIVCTTPPYAnPGPGPVEVTVDRGNGGIT 79
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 1240-1317 7.03e-08

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 52.45  E-value: 7.03e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755551237  1240 PVVTDFSPKERTVLGKVNLTIKGYNFGNELAQNTVYVGRKHCQVLHSNFTDITCLLPTLPPGKHDIYVKVRNWGLAST 1317
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGISSS 78
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1067-1154 8.54e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 52.46  E-value: 8.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1067 PLILTTTPSEGSYAESTILTIAGSGFSPTSA-VSVSVGSTRCSLLSVEENEIKCQIL-NGSAGHVPVAVSIaDVGLAQNL 1144
Cdd:cd00603     1 PVITSISPSSGPLSGGTRLTITGSNLGSGSPrVRVTVGGVPCKVLNVSSTEIVCRTPaAATPGEGPVEVTV-DGANVSAR 79

                          90
                  ....*....|
gi 755551237 1145 EGEGSHFIYR 1154
Cdd:cd00603    80 VLSNTTFTYV 89
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 31-128 9.13e-08

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 52.08  E-value: 9.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   31 PKVTEVIPKYGSINGATRLTIKGEGFSQasqfnygadntelGNHVQlVSSFQSITCDVEkdSSHSTQITCYTRAMPE-DT 109
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGS-------------GSNLR-VTFGGGVPCSVL--SVSSTAIVCTTPPYANpGP 64

                          90
                  ....*....|....*....
gi 755551237  110 YSVRVSVDGVPVAENNTCK 128
Cdd:cd00102    65 GPVEVTVDRGNGGITSSPL 83
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1331-1384 9.33e-08

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 52.07  E-value: 9.33e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 755551237 1331 VIHMF-PQRGSLYGGTEITIMGFGFSTIPTENSVLLGSFPCDITSSSENVIKCTL 1384
Cdd:cd00603     2 VITSIsPSSGPLSGGTRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRT 56
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1658-1744 9.95e-08

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 51.84  E-value: 9.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1658 PNIDMVMPKAGSTTGMTRVTIQGSgFMSSPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQ-QLVLVDILIHGvpAQCQS 1736
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGK-HLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASpGEAPVKVLIDG--ARRLA 77


                  ....*...
gi 755551237 1737 NCSFSYLE 1744
Cdd:cd01179    78 PLVFTYTE 85
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1830-1898 7.36e-07

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 49.62  E-value: 7.36e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755551237 1830 PAVASVSPTSGSIAGGTTLMITGN--GFSPG--NTTVTVGDQPCQIT---FISSSEVYCSTPAGRAGTANLKISVN 1898
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSnlGLRKNdvRHGVRVGGVPCNPEppeYSSSEKIVCTTGPAGNPVFNGPVEVT 76
PA14 pfam07691
PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other ...
 363-467 7.92e-07

PA14 domain; This domain forms an insert in bacterial beta-glucosidases and is found in other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins, including anthrax protective antigen (PA). The domain also occurs in a Dictyostelium prespore-cell-inducing factor Psi and in fibrocystin, the mammalian protein whose mutation leads to polycystic kidney and hepatic disease. The crystal structure of PA shows that this domain (named PA14 after its location in the PA20 pro-peptide) has a beta-barrel structure. The PA14 domain sequence suggests a binding function, rather than a catalytic role. The PA14 domain distribution is compatible with carbohydrate binding.


Pssm-ID: 400161 [Multi-domain]  Cd Length: 141  Bit Score: 51.21  E-value: 7.92e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   363 EHTPGYMGATW-TDSASYvwPIEQDTFVARISGFLVPPDSDVYRFYIRGDDRYAIYFSqtgrteDKVRIAYysgNANTYF 441
Cdd:pfam07691   22 IDTDPDNTFYWdTDVPGF--GEAPGDFSARWTGYLLPPESGTYTFGVASDDGARLWID------GELVIDN---WGQHPP 90

                           90       100
                   ....*....|....*....|....*.
gi 755551237   442 SNSTQRSDEIHLQKGKEYYIEILLQE 467
Cdd:pfam07691   91 DASPEESNTLYLVAGKLYPIRIEYFH 116
PA14 smart00758
domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, ...
 341-467 9.72e-07

domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins;


Pssm-ID: 214807 [Multi-domain]  Cd Length: 136  Bit Score: 50.86  E-value: 9.72e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237    341 GLKVEVWNNSRPAHLEDIleynEHTPGYMGATW-TDSASYvwPIEQDTFVARISGFLVPPDSDVYRFYIRGDDRYAIYFS 419
Cdd:smart00758    2 GLTGYYFENEKFSGLPEI----IDTDPLNTFYWdSDKFGE--GEKADNFSVRWTGYLKPPEDGEYTFSITSDDGARLWID 75

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....*...
gi 755551237    420 qtgrteDKVRIayysgNANTYFSNSTQRSDEIHLQKGKEYYIEILLQE 467
Cdd:smart00758   76 ------GKLVI-----DNWGKHEARPSTSSTLYLLAGGTYPIRIEYFE 112
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1915-1996 1.17e-06

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 49.00  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1915 PFLKRIIPNRGLP--GTEVEITGSNLGFAiSDVSVMIKESV-CNVTTVNDTVLQCTVGE-HAGGIFPVTMLHKTKGSAV- 1989
Cdd:cd00102     1 PVITSISPSSGPVsgGTEVTITGSNFGSG-SNLRVTFGGGVpCSVLSVSSTAIVCTTPPyANPGPGPVEVTVDRGNGGIt 79


                  ....*...
gi 755551237 1990 -SSVAFEY 1996
Cdd:cd00102    80 sSPLTFTY 87
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1658-1744 2.37e-06

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 48.47  E-value: 2.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1658 PNIDMVMPKAGSTTGMTRVTIQGSGFMSSPEGVE--VFMGDFPCKVLSVTY---TAIECETSPAPQQL--VLVDILIHGV 1730
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLGLRKNDVRhgVRVGGVPCNPEPPEYsssEKIVCTTGPAGNPVfnGPVEVTVGHG 80

                          90
                  ....*....|....
gi 755551237 1731 PAQCQSNCSFSYLE 1744
Cdd:cd01180    81 SFRTESSEGFSFVD 94
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1067-1155 4.00e-06

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 47.46  E-value: 4.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1067 PLILTTTPSEGSYAESTILTIAGSGFSPTSAVSVSV-GSTRCSLLSVEENEIKCQI---LNGSAGHVPVAVSIADVGLAQ 1142
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFgGGVPCSVLSVSSTAIVCTTppyANPGPGPVEVTVDRGNGGITS 80

                          90
                  ....*....|...
gi 755551237 1143 NlegeGSHFIYRS 1155
Cdd:cd00102    81 S----PLTFTYVP 89
IPT smart00429
ig-like, plexins, transcription factors;
1997-2085 6.88e-06

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 47.03  E-value: 6.88e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   1997 PLSIQNIYPTQGSFGGGQTLTVTGMGFDPWNS---TILVCNSECAVdkLRSNSTTLFCVIPPNNGKGHDQ-VCGVSVVNG 2072
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVvfvEVGVGEAPCTF--SPSSSTAIVCKTPPYHNIPGSVpVRTVGLRNG 78

                            90
                    ....*....|...
gi 755551237   2073 kDSSHSTKLFTYT 2085
Cdd:smart00429   79 -GVPSSPQPFTYV 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 31-126 1.11e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 46.29  E-value: 1.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237    31 PKVTEVIPKYGSINGATRLTIKGEGFSQASqfnygaDNTELgnhvqlvsSFQSITCDVEKDSshSTQITCYTRAMPEDTY 110
Cdd:pfam01833    1 PVITSISPSSGPASGGTTITITGSNFGTDS------SDLKV--------TIGGTPCTVISVS--STTIVCTTPPGTSGLV 64

                           90
                   ....*....|....*.
gi 755551237   111 SVRVSVDGVPVAENNT 126
Cdd:pfam01833   65 NVSVTVGGGGISSSPL 80
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1157-1234 1.25e-05

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 46.15  E-value: 1.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1157 ISHVWPDSGSLAGGTLLTISG--FGFSEN---STVLVGNETCNVIEG---DLNRITCRT----SKRIEGTVDISVITNGI 1224
Cdd:cd01180     3 ITEFFPLSGPLEGGTRLTICGsnLGLRKNdvrHGVRVGGVPCNPEPPeysSSEKIVCTTgpagNPVFNGPVEVTVGHGSF 82

                          90
                  ....*....|
gi 755551237 1225 QVTAKDSFSY 1234
Cdd:cd01180    83 RTESSEGFSF 92
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1999-2084 1.31e-05

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 46.15  E-value: 1.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1999 SIQNIYPTQGSFGGGQTLTVTG--MGFDPW--NSTILVCNSECAVDKLR-SNSTTLFCVIPPNNGKGHDQVCGVSVVNGK 2073
Cdd:cd01180     2 VITEFFPLSGPLEGGTRLTICGsnLGLRKNdvRHGVRVGGVPCNPEPPEySSSEKIVCTTGPAGNPVFNGPVEVTVGHGS 81

                          90
                  ....*....|.
gi 755551237 2074 DSSHSTKLFTY 2084
Cdd:cd01180    82 FRTESSEGFSF 92
Halocyanin cd04220
Halocyanin is an archaea blue (type I) copper redox protein; Halocyanins are blue (type I) ...
 1405-1478 2.58e-05

Halocyanin is an archaea blue (type I) copper redox protein; Halocyanins are blue (type I) copper redox proteins found in halophilic archaea such as Natronomonas pharaonis (Natronobacterium pharaonis). Halocyanin may serve as a mobile electron carrier at a peripheral membrane protein. The copper-binding domain is present only once in some halocyanins and is duplicated in others.


Pssm-ID: 259882 [Multi-domain]  Cd Length: 92  Bit Score: 45.46  E-value: 2.58e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755551237 1405 GYAWSPSVLNVTVGDTVVWSWQAHpflrGIGYRIfsVSSPGSVTYDDKGFTNgrqKSASGSFSYQFTSPGIYYY 1478
Cdd:cd04220    11 GFAFDPAAIRVSPGTTVTWEWTGE----GGGHNV--VAYEDPITAFDSGSTD---SSEGETYEHTFEETGEYRY 75
IPT smart00429
ig-like, plexins, transcription factors;
1657-1743 2.60e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 45.10  E-value: 2.60e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   1657 LPNIDMVMPKAGSTTGMTRVTIQGSGFMS-SPEGVEVFMGDFPCKVLSVTYTAIECETSPAPQQLVL-----VDILIHGV 1730
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSiSVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSvpvrtVGLRNGGV 80

                            90
                    ....*....|...
gi 755551237   1731 PAQCQsncSFSYL 1743
Cdd:smart00429   81 PSSPQ---PFTYV 90
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 146-255 2.79e-05

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 45.13  E-value: 2.79e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   146 PTIRSITPLSGTP--GTLITIKGRLFtdvygsntalssnGRNVRILRIYIGGMPCELlIPHSDDlyglkldhangdtgSV 223
Cdd:pfam01833    1 PVITSISPSSGPAsgGTTITITGSNF-------------GTDSSDLKVTIGGTPCTV-ISVSST--------------TI 52

                           90       100       110
                   ....*....|....*....|....*....|..
gi 755551237   224 TCKTTGTYIGHHNVSFILDSDYGRSFPEKMTY 255
Cdd:pfam01833   53 VCTTPPGTSGLVNVSVTVGGGGISSSPLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
1067-1154 2.86e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 45.10  E-value: 2.86e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   1067 PLILTTTPSEGSYAESTILTIAGSGFSPTSAVSVSV--GSTRCSLLSVEENEIKCQILNGSAGHVPVAVSIADVGLAqNL 1144
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVgvGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLRNG-GV 80

                            90
                    ....*....|
gi 755551237   1145 EGEGSHFIYR 1154
Cdd:smart00429   81 PSSPQPFTYV 90
PetE COG3794
Plastocyanin [Energy production and conversion];
1406-1478 3.13e-05

Plastocyanin [Energy production and conversion];


Pssm-ID: 443008 [Multi-domain]  Cd Length: 76  Bit Score: 44.60  E-value: 3.13e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755551237 1406 YAWSPSVLNVTVGDTVVWSWQAhpflrGIGYRIFSVSSPgsvtydDKGFTNGRQKsASGSFSYQFTSPGIYYY 1478
Cdd:COG3794     1 MAFEPATLTVKPGDTVTWVNTD-----SVPHNVTSDDGP------DGAFDSGLLA-PGETFSVTFDEPGTYDY 61
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1157-1234 3.37e-05

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 44.91  E-value: 3.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1157 ISHVWPDSGSLAGGTLLTISGFGFSENST--VLVGNETCNVIEGDLNRITCRTSKRIE-GTVDISVITNGIQVTAKDSFS 1233
Cdd:cd01179     3 ITSLSPSYGPQSGGTRLTITGKHLNAGSSvrVTVGGQPCKILSVSSSQIVCLTPPSASpGEAPVKVLIDGARRLAPLVFT 82


                  .
gi 755551237 1234 Y 1234
Cdd:cd01179    83 Y 83
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 1565-1623 4.78e-05

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 44.37  E-value: 4.78e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755551237 1565 PSIINITPSTGTANE--LITIIGHGFSSLPCANKVTIGSYPCVVEESSENSIICHIDPQNS 1623
Cdd:cd00603     1 PVITSISPSSGPLSGgtRLTITGSNLGSGSPRVRVTVGGVPCKVLNVSSTEIVCRTPAAAT 61
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 270-329 6.42e-05

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 44.23  E-value: 6.42e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755551237  270 PEVVMVSPSKGSTEGGTLLTIHGHFF--DQTDLPVRVLVGGQACAILN---VTENTIYCKTPPKP 329
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLglRKNDVRHGVRVGGVPCNPEPpeySSSEKIVCTTGPAG 65
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1329-1383 6.73e-05

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 43.99  E-value: 6.73e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 755551237 1329 LEVIHMFPQRGSLYGGTEITIMGFGFSTIPTENSVLLGSFPCDITSSSENVIKCT 1383
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGSNLRVTFGGGVPCSVLSVSSTAIVCT 55
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1915-1981 9.41e-05

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 43.37  E-value: 9.41e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755551237 1915 PFLKRIIPNRGlP---GTEVEITGSNLGfAISDVSVMIKESVCNVTTVNDTVLQCTVGEHA-GGIFPVTML 1981
Cdd:cd01179     1 PSITSLSPSYG-PqsgGTRLTITGKHLN-AGSSVRVTVGGQPCKILSVSSSQIVCLTPPSAsPGEAPVKVL 69
IPT smart00429
ig-like, plexins, transcription factors;
1157-1234 1.38e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 43.18  E-value: 1.38e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   1157 ISHVWPDSGSLAGGTLLTISGFGF----SENSTVLVGNETCNVIEGDLNRITCRTSKRIEGTVDISVITNGIQ---VTAK 1229
Cdd:smart00429    4 ITRISPTSGPVSGGTEITLCGKNLksisVVFVEVGVGEAPCTFSPSSSTAIVCKTPPYHNIPGSVPVRTVGLRnggVPSS 83


                    ....*.
gi 755551237   1230 DS-FSY 1234
Cdd:smart00429   84 PQpFTY 89
Amicyanin cd13921
Amicyanin is a type I blue copper protein that plays an essential role in electron transfer; ...
 1398-1478 3.14e-04

Amicyanin is a type I blue copper protein that plays an essential role in electron transfer; In Paracoccus denitrificans bacteria, amicyanin acts as an intermediary of a three-member redox complex along with methylamine dehydrogenase (MADH) and cytochrome c-551i. The electron is transferred from the active site of MADH via the amicyanin copper ion to the cytochrome heme iron. The electron transfer from MADH to cytochrome c-551i does not involve a ternary complex but occurs via a ping-pong mechanism in which amicyanin uses the same interface for the reactions with MADH and cytochrome c-551i.


Pssm-ID: 259988 [Multi-domain]  Cd Length: 81  Bit Score: 41.93  E-value: 3.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1398 SHLVHGLGYAWSPSVLNVTVGDTVVWswqahpflrgigyrIFSVSSPGSVTYDDKGFTnGRQKSASGSFSYQFTSPGIYY 1477
Cdd:cd13921     1 THVVTIEDFKFNPAEVTVKVGDTVTW--------------TNKDSVPHTVTAEDGAFD-SGMLATGKSFSYTFTAAGTYD 65


                  .
gi 755551237 1478 Y 1478
Cdd:cd13921    66 Y 66
IPT smart00429
ig-like, plexins, transcription factors;
31-119 5.16e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 41.64  E-value: 5.16e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237     31 PKVTEVIPKYGSINGATRLTIKGEGFSQASQFNYGADNTElgnhvqlvssfqsITCDVekDSSHSTQITCYTRAMPEDTY 110
Cdd:smart00429    2 PVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGVGE-------------APCTF--SPSSSTAIVCKTPPYHNIPG 66


                    ....*....
gi 755551237    111 SVRVSVDGV 119
Cdd:smart00429   67 SVPVRTVGL 75
IPT_plexin_repeat2 cd01179
Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1067-1154 5.98e-04

Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238584  Cd Length: 85  Bit Score: 41.06  E-value: 5.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1067 PLILTTTPSEGSYAESTILTIAGSGFSPTSAVSVSVGSTRCSLLSVEENEIKCQILNGSAGH-VPVAVSIadvGLAQNLe 1145
Cdd:cd01179     1 PSITSLSPSYGPQSGGTRLTITGKHLNAGSSVRVTVGGQPCKILSVSSSQIVCLTPPSASPGeAPVKVLI---DGARRL- 76


                  ....*....
gi 755551237 1146 gEGSHFIYR 1154
Cdd:cd01179    77 -APLVFTYT 84
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1922-1996 6.00e-04

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 41.53  E-value: 6.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1922 PNRGlpGTEVEITGSNLGFAISDV--SVMIKESVCNVTT---VNDTVLQCTVGEHAGGIFP----VTMLHKTKGsAVSSV 1992
Cdd:cd01180    12 PLEG--GTRLTICGSNLGLRKNDVrhGVRVGGVPCNPEPpeySSSEKIVCTTGPAGNPVFNgpveVTVGHGSFR-TESSE 88


                  ....
gi 755551237 1993 AFEY 1996
Cdd:cd01180    89 GFSF 92
IPT smart00429
ig-like, plexins, transcription factors;
1331-1384 9.27e-04

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.87  E-value: 9.27e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 755551237   1331 VIH-MFPQRGSLYGGTEITIMGFGFSTIPTEN-SVLLGSFPCDITSSSENVIKCTL 1384
Cdd:smart00429    3 VITrISPTSGPVSGGTEITLCGKNLKSISVVFvEVGVGEAPCTFSPSSSTAIVCKT 58
IPT_PCSR cd00603
IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup ...
 146-244 1.09e-03

IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the macrophage-stimulating receptors and of fibrocystin. Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT_PCSR domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238337 [Multi-domain]  Cd Length: 90  Bit Score: 40.52  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  146 PTIRSITPLSGTP--GTLITIKGRLFtdvygsntalssnGRNVRILRIYIGGMPCELLiphsddlyglkldhaNGDTGSV 223
Cdd:cd00603     1 PVITSISPSSGPLsgGTRLTITGSNL-------------GSGSPRVRVTVGGVPCKVL---------------NVSSTEI 52

                          90       100
                  ....*....|....*....|..
gi 755551237  224 TCKT-TGTYIGHHNVSFILDSD 244
Cdd:cd00603    53 VCRTpAAATPGEGPVEVTVDGA 74
IPT smart00429
ig-like, plexins, transcription factors;
1919-1996 1.11e-03

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 40.48  E-value: 1.11e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   1919 RIIPNRGLP--GTEVEITGSNLGfAISDVSVMIK--ESVCNVTTVNDTVLQCTVGEHAGGIFPV---TMLHKTKGSAVSS 1991
Cdd:smart00429    6 RISPTSGPVsgGTEITLCGKNLK-SISVVFVEVGvgEAPCTFSPSSSTAIVCKTPPYHNIPGSVpvrTVGLRNGGVPSSP 84


                    ....*
gi 755551237   1992 VAFEY 1996
Cdd:smart00429   85 QPFTY 89
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 31-118 2.24e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 39.99  E-value: 2.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237   31 PKVTEVIPKYGSINGATRLTIKGEGFsqasQFNYgadntELGNHVQLVSsfqSITCDVEKDSSH-STQITCYTRAMPED- 108
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNL----GLRK-----NDVRHGVRVG---GVPCNPEPPEYSsSEKIVCTTGPAGNPv 68

                          90
                  ....*....|.
gi 755551237  109 -TYSVRVSVDG 118
Cdd:cd01180    69 fNGPVEVTVGH 79
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 1565-1647 2.48e-03

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 39.75  E-value: 2.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 1565 PSIINITPSTGTAN--ELITIIGHGFSSLPCAnKVTI-GSYPCVVEESSENSIICHIDPQ-NSMNVGIReiVTLIVYNLG 1640
Cdd:cd00102     1 PVITSISPSSGPVSggTEVTITGSNFGSGSNL-RVTFgGGVPCSVLSVSSTAIVCTTPPYaNPGPGPVE--VTVDRGNGG 77


                  ....*..
gi 755551237 1641 TAINTLT 1647
Cdd:cd00102    78 ITSSPLT 84
IPT_NFAT cd01178
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a ...
 2005-2085 2.59e-03

IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.


Pssm-ID: 238583  Cd Length: 101  Bit Score: 39.78  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237 2005 PTQGSFGGGQTLTVTGMGFDPWNSTILVCNS---------ECAVDKLRSNSTTLFCVIPPNngkgHDQV------CGVSV 2069
Cdd:cd01178     9 LNSCSVNGGEELFLTGKNFLKDSKVVFQEKGqdgeaqweaEATIDKEKSHQNHLVVEVPPY----HNKHvaapvqVQFYV 84

                          90
                  ....*....|....*.
gi 755551237 2070 VNGKDSSHSTKLFTYT 2085
Cdd:cd01178    85 VNGKRKRSQPQTFTYT 100
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1240-1309 5.45e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 38.84  E-value: 5.45e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755551237 1240 PVVTDFSPKERTVLGKVNLTIKGYNFGN--ELAQNTVYVGRKHCQVLHSNFTD---ITCLLPTLPPGKHDIYVKV 1309
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSNLGLrkNDVRHGVRVGGVPCNPEPPEYSSsekIVCTTGPAGNPVFNGPVEV 75
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 146-203 8.13e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 38.45  E-value: 8.13e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551237  146 PTIRSITPLSGTP--GTLITIkgrlftdvYGSNTALSSNGRNVRIlriYIGGMPCELLIP 203
Cdd:cd01180     1 PVITEFFPLSGPLegGTRLTI--------CGSNLGLRKNDVRHGV---RVGGVPCNPEPP 49
IPT_plexin_repeat1 cd01180
First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are ...
 1067-1137 9.05e-03

First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present preceeded by SEMA (semaphorin) and PSI (plexin, semaphorin, integrin) domains.


Pssm-ID: 238585  Cd Length: 94  Bit Score: 38.07  E-value: 9.05e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755551237 1067 PLILTTTPSEGSYAESTILTIAGS--GFSPT-SAVSVSVGSTRCSLLSVEE---NEIKCQI--LNGSAGHVPVAVSIAD 1137
Cdd:cd01180     1 PVITEFFPLSGPLEGGTRLTICGSnlGLRKNdVRHGVRVGGVPCNPEPPEYsssEKIVCTTgpAGNPVFNGPVEVTVGH 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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