BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547585 374 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDSEDDIVEMSEFSYPVFRAFLEYLYTDNI 453
Cdd:cd18354    1 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYVHKVLLKIRCEHFRSLLNENEEEIIEMSQFSYPVYRAFLEYLYTDSI 80

                         90
                 ....*....|
gi 755547585 454 SLSPEEAVGL 463
Cdd:cd18354   81 SLSPEDAIGL 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547585 374 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDSEDDIVEMSEFSYPVFRAFLEYLYTDNI 453
Cdd:cd18354    1 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYVHKVLLKIRCEHFRSLLNENEEEIIEMSQFSYPVYRAFLEYLYTDSI 80

                         90
                 ....*....|
gi 755547585 454 SLSPEEAVGL 463
Cdd:cd18354   81 SLSPEDAIGL 90

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755547585   395 DLKFLVDGKYIYAHKVLLKIRCEHFRSSLED----SEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEEAVGL 463
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSdfkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEEL 73

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547585  71 GTNCSGCLGVGDIQSTIEPRRLDSLTGkkIASLSYGSGpHIVLATTDGEVFTWGHNAYSQLGNGTTNHGLVPCHIStNLS 150
Cdd:COG5184   23 GDNSYGQLGDGTTTDRSTPVRVPGLSN--VVAVAAGGD-HTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVP-GLT 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547585 151 NkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGCLQNkvVMNIACGQMCSMAVVDTGEVYVWG 230
Cdd:COG5184   99 G--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG--VVAIAAGGYHTCALKSDGTVWCWG 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547585 231 YNGNGQLGLGSSGNQPTPCRVAALQGirVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDrI 310
Cdd:COG5184  175 ANSYGQLGDGTTTDRPTPVQVGGLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG-V 251

                        250       260
                 ....*....|....*....|....*.
gi 755547585 311 IEIAAchSAHTSAAKTQGGHVYMWGQ 336
Cdd:COG5184  252 VAIAA--GGSHTCALKSDGTVWCWGD 275

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547585  71 GTNCSGCLGVGDIQSTIEPRRLDsLTGKKIASLSYGSGpHIVLATTDGEVFTWGHNAYSQLGNGTTNHGLVPCHISTnLS 150
Cdd:COG5184  123 GDNSSGQLGDGTTTNRLTPVQVD-AGLSGVVAIAAGGY-HTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGG-LS 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547585 151 NkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGcLQNkvVMNIACGQMCSMAVVDTGEVYVWG 230
Cdd:COG5184  200 G--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAG-LTG--VVAIAAGGSHTCALKSDGTVWCWG 274

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755547585 231 YNGNGQLGLGSSGNQPTPCRVAALQGirVQRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPT 301
Cdd:COG5184  275 DNSYGQLGDGTTTDRSTPVKVPGLSG--VVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTPV 343

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547585 155 IEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTANQPIPRRVTGcLQNkvVMNIACGQMCSMAVVDTGEVYVWGYNGN 234
Cdd:COG5184    1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPG-LSN--VVAVAAGGDHTCALKADGTVWCWGNNSY 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547585 235 GQLGLGSSGNQPTPCRVAALQGIRvqRVACGYAHTLVLTDEGQIYAWGANSYGQLGTGNKSNQSYPTPVVVEKDRIIEIA 314
Cdd:COG5184   78 GQLGDGTTTDRTTPVKVPGLTGVV--AVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSGVVAIA 155

                        170       180
                 ....*....|....*....|.
gi 755547585 315 AchSAHTSAAKTQGGHVYMWG 335
Cdd:COG5184  156 A--GGYHTCALKSDGTVWCWG 174

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547585 382 ESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLED----SEDDIVEMSEFSYPVFRAFLEYLYTDNISLSP 457
Cdd:cd18298    1 DSLRKAFNDPRTSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQShwneDDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPP 80

                 ....*.
gi 755547585 458 EEAVGL 463
Cdd:cd18298   81 EDAIGL 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547585 394 ADLKFLVDGKYIYAHKVLLKIRCEHFR----SSLEDSEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEEAVGL 463
Cdd:cd18186    2 CDVTLVVGGREFPAHRAVLAARSPYFRamfsSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEEL 75

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547585 388 FDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRS-----SLEDSEDDIvEMSEFSYPVFRAFLEYLYT---DNISLSPEE 459
Cdd:cd18297    7 VNNPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSmlssgSTEAQTPVI-EIPDIRYDIFQLMMQYLYTggvESLDVAQDD 85

                 ....*..
gi 755547585 460 AVGLRRV 466
Cdd:cd18297   86 ALELLRA 92

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755547585   395 DLKFLVDGKYIYAHKVLLKIRCEHFRSSLED----SEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEEAVGL 463
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSdfkeSDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEEL 73

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547585 376 DHLT-VAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRS----SLEDSEDDIVEMSEFSYPVFRAFLEYLYT 450
Cdd:cd18287    4 DHVHfLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRAllygGMRESQQSEIELKDTNAEAFKALLKYIYT 83

                         90       100
                 ....*....|....*....|....*.
gi 755547585 451 DNISLSPEEavglRRVLLQVL---HQ 473
Cdd:cd18287   84 GRLTLTDLK----EDVLLDVLglaHQ 105

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547585  384 LKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFR----SSLEDSEDDIVEMSEFSYPVFRAFLEYLYTDNI 453
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKalfsGQESESSVSEITLDDVSPEDFEALLEFMYTGKL 74

Regulator of chromosome condensation (RCC1) repeat;

                          10        20        30
                  ....*....|....*....|....*....|
gi 755547585  154 VIEVACGSYHSLVLTSDGEVFAWGYNNSGQ 183
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547585 389 DNPDTADLKFLVDGKYIYAHKVLLKIRCEHF------RSSLEDSEDDIVEMSEFSYPVFRAFLEYLY 449
Cdd:cd18350   20 NNKEMSDVTFLVEGKLFYAHKVLLVTASNRFkslltnKSEQESQGSKTIEISDIKYHIFQMLMQYLY 86

Regulator of chromosome condensation (RCC1) repeat;

                          10        20        30
                  ....*....|....*....|....*....|
gi 755547585  259 VQRVACGYAHTLVLTDEGQIYAWGANSYGQ 288
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547585 389 DNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLE----DSEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEEAVGLR 464
Cdd:cd18352    9 NNATLSDVTFLVEGRRFYAHRIALLASSDAFRAMFDggyrEKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLL 88

                 ....*..
gi 755547585 465 RVLLQVL 471
Cdd:cd18352   89 RAADQYL 95

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755547585 388 FDNPDTADLKFLVDGKYIYAHKVLLKIRCEhFRSSLEDSEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEE 459
Cdd:cd18303   13 FDKELYSDITIKLADKSIPAHKFVLAARSE-KWSNENLASTNELDLSDISYEVVLALLRWLYTDELDLTLDD 83

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547585 388 FDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSL-----EDSEDDIVeMSEFSYPVFRAFLEYLYTDNISLSPEEAVG 462
Cdd:cd18314    1 YNDSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLtgsmiESNLKEVT-LEDVEPEIFETVLKYMYTGQVTLSEENVLD 79

                 ....
gi 755547585 463 LRRV 466
Cdd:cd18314   80 LLML 83

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755547585 389 DNPDTADLKFL-VDGKYIYAHKVLLKIRCEHFRSSL-----EDSEDDIVEMsEFSYPVFRAFLEYLYTDNISLSPE 458
Cdd:cd18302    1 KHSDLYDVTIVsEDGKEFPCHKCVLVARLEYFHSMLssswiEASSCSALTM-PIPSDILEIILDYLYTDEASAVKE 75

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755547585 382 ESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLED--SEDDIVEMSE--FSYPVFRAFLEYLYTD 451
Cdd:cd18295    8 EFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETkwKDKREINLKHplVNPDAFRALLQYLYTG 81

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755547585 388 FDNPDTADLKFLVDGKY-IYAHKVLLKIRCEHFRSSLedSEDDIVEMSE-FSYPVFRAFLEYLYT 450
Cdd:cd18299    7 LHSPSCADVVFILQGGVrIFAHRIVLAAASSVFADLF--LMMTVVTLDSdITPEAFRRVLEFLYT 69

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755547585 389 DNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSL------EDSEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPE 458
Cdd:cd18245   10 EEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLnynppkDDGSTYKIELEGISVEVMEEILDYIYTGQIKLSED 85

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755547585 385 KREFDNpdTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLED-SEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEEAV 461
Cdd:cd18221   12 QRELDQ--FTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDfTQEPLVEIEGVSNMAFRHLIEFTYTAKLMVQGEEEA 87

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755547585 395 DLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDsedDIVEMSEFSYPVFRAFLEYLYTDNISLSPEEAV 461
Cdd:cd18275    6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLSR---DILKVKGLSYATLRLLVDYVYSGRMAVSKDNVV 69

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547585 395 DLKFLVDGKYIYAHKVLLKIRCEHFRSSL-----------EDSEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEEAVGl 463
Cdd:cd18228   21 DVTIRVQDKIFRAHKVVLAACSDFFRSKLvgqasprlvlvSPAGKCVLDLHHVTVTGFAPLLEYAYTSTLSINTENIID- 99

                         90       100
                 ....*....|....*....|
gi 755547585 464 rrVL-----LQVLHQPSDCS 478
Cdd:cd18228  100 --VLaaasyMQMFNVANTCS 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755547585 395 DLKFLVDGKYIYAHKVLLKIRCEHFR----SSLEDSEDDIVEMSEFSYPVFRAFLEYLYTDNISLS 456
Cdd:cd18251   25 DVVLVVEGKPIEAHRILLAASCDYFRgmfaGGLREMQQTEVLIHGVSYNAMCKILDFIYTSELELS 90

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755547585 394 ADLKFLVDGKYIYAHKVLLKIRCEHFRSSLED---SEDDIVEMSEFSYPVFRAFLEYLYTDNISLSPEE 459
Cdd:cd18315    2 VDVTLACEGGSLKAHKLVLAAASPYFAALLKEtppDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQ 70

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547585 394 ADLKFLVDGKYIYAHKVLLKIRCEHF-------RSSLEDseDDIVEMSEFSYPVFRAFLEYLYTDNISLS-PEEAVGLRR 465
Cdd:cd18285   16 TDVTFYVGSTLFKAHKAILLARVPEFfshiigkLSSLED--QEPINIENLEASEFKTFLRQVYTSDKNIKmLEEEILKGK 93

                         90
                 ....*....|.
gi 755547585 466 VLLQVLHQPSD 476
Cdd:cd18285   94 VLDQKVDKEND 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755547585 379 TVAESLKREFDNPDTADLKFLVdGK-----YIYAHKVLLKIRC----EHFRSSLEDSEDDIvEMSEFSYPVFRAFLEYLY 449
Cdd:cd18281    8 TVKERFAFLFNNETLSDVHFIV-GKgdneqRIPAHKFVLSIGSavfdAMFNGGMATTSAEI-ELPDVEPAAFLALLRFLY 85

                 ....*....
gi 755547585 450 TDNISLSPE 458
Cdd:cd18281   86 SDEVQIGPE 94