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Conserved domains on  [gi|755541461|ref|XP_011242195|]
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cadherin-related family member 3 isoform X3 [Mus musculus]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182011)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  17158740|28268172|27782885|11736639
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 186-282 7.87e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.07  E-value: 7.87e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755541461 186 SYVFDVPERRPARTQIGQVRATDADFPRT-PVVYSVSRGGSslqyPNIFWINPKTGELQLITQADHETTSVYILTVEATN 264
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENgEVTYSIVSGNE----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|.
gi 755541461 265 GED---RSSVTVTVNILGEND 282
Cdd:cd11304   77 GGGpplSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 292-400 1.84e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 1.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755541461 292 YFMAIPVDLKVGTNIqnFKLTCTDLDSSP-SSFRYSIGSGNINNHFTFSPNAGsnitRLLLASRFDYSSLDTvwdYQLLV 370
Cdd:cd11304    2 YEVSVPENAPPGTVV--LTVSATDPDSGEnGEVTYSIVSGNEDGLFSIDPSTG----EITTAKPLDREEQSS---YTLTV 72

                         90       100       110
                 ....*....|....*....|....*....|
gi 755541461 371 HITDDNLLSGSTkakalvetgTVTLSVKVI 400
Cdd:cd11304   73 TATDGGGPPLSS---------TATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 8-62 4.48e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 48.08  E-value: 4.48e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755541461   8 PVTGTIQVARRLDRDagelrQNPIISLEVRVRDRPSGGQENRMQITFIVEDINDN 62
Cdd:cd11304   49 PSTGEITTAKPLDRE-----EQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 186-282 7.87e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.07  E-value: 7.87e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755541461 186 SYVFDVPERRPARTQIGQVRATDADFPRT-PVVYSVSRGGSslqyPNIFWINPKTGELQLITQADHETTSVYILTVEATN 264
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENgEVTYSIVSGNE----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|.
gi 755541461 265 GED---RSSVTVTVNILGEND 282
Cdd:cd11304   77 GGGpplSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
187-278 5.62e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.41  E-value: 5.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755541461  187 YVFDVPERRPARTQIGQVRATDADF-PRTPVVYSVSRGGSSlqypNIFWINPKTGELQLITQADHETTSVYILTVEATN- 264
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLgPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDs 76

                          90
                  ....*....|....*.
gi 755541461  265 -GEDRSSV-TVTVNIL 278
Cdd:pfam00028  77 gGPPLSSTaTVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 205-285 1.22e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.52  E-value: 1.22e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755541461   205 RATDADFPR-TPVVYSVSRGGsslqYPNIFWINPKTGELQLITQADHETTSVYILTVEATNGEDR---SSVTVTVNILGE 280
Cdd:smart00112   1 SATDADSGEnGKVTYSILSGN----DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplsSTATVTITVLDV 76


                   ....*
gi 755541461   281 NDEKP 285
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 292-400 1.84e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 1.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755541461 292 YFMAIPVDLKVGTNIqnFKLTCTDLDSSP-SSFRYSIGSGNINNHFTFSPNAGsnitRLLLASRFDYSSLDTvwdYQLLV 370
Cdd:cd11304    2 YEVSVPENAPPGTVV--LTVSATDPDSGEnGEVTYSIVSGNEDGLFSIDPSTG----EITTAKPLDREEQSS---YTLTV 72

                         90       100       110
                 ....*....|....*....|....*....|
gi 755541461 371 HITDDNLLSGSTkakalvetgTVTLSVKVI 400
Cdd:cd11304   73 TATDGGGPPLSS---------TATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 8-62 4.48e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 48.08  E-value: 4.48e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755541461   8 PVTGTIQVARRLDRDagelrQNPIISLEVRVRDRPSGGQENRMQITFIVEDINDN 62
Cdd:cd11304   49 PSTGEITTAKPLDRE-----EQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 8-63 8.00e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.96  E-value: 8.00e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 755541461     8 PVTGTIQVARRLDRDagelrQNPIISLEVRVRDRPSGGQENRMQITFIVEDINDNP 63
Cdd:smart00112  30 PETGEITTTKPLDRE-----EQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
292-400 1.15e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.83  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755541461  292 YFMAIPVDLKVGTNIQNfkLTCTDLDSSP-SSFRYSIGSGNINNHFTFSPNAGSnitrLLLASRFDYSSLDTvwdYQLLV 370
Cdd:pfam00028   1 YSASVPENAPVGTEVLT--VTATDPDLGPnGRIFYSILGGGPGGNFRIDPDTGD----ISTTKPLDRESIGE---YELTV 71

                          90       100       110
                  ....*....|....*....|....*....|
gi 755541461  371 HITDdnllsGSTKAKalveTGTVTLSVKVI 400
Cdd:pfam00028  72 EATD-----SGGPPL----SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
8-57 1.36e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.05  E-value: 1.36e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 755541461    8 PVTGTIQVARRLDRDagelrQNPIISLEVRVRDRPSGGQENRMQITFIVE 57
Cdd:pfam00028  48 PDTGDISTTKPLDRE-----SIGEYELTVEATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 314-400 2.32e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 36.94  E-value: 2.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755541461   314 TDLDSSPSS-FRYSIGSGNINNHFTFSPNAGsnitRLLLASRFDYSSLDTvwdYQLLVHITDdnllsGSTKAKalveTGT 392
Cdd:smart00112   3 TDADSGENGkVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPE---YTLTVEATD-----GGGPPL----SST 66


                   ....*...
gi 755541461   393 VTLSVKVI 400
Cdd:smart00112  67 ATVTITVL 74
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 186-282 7.87e-22

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 90.07  E-value: 7.87e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755541461 186 SYVFDVPERRPARTQIGQVRATDADFPRT-PVVYSVSRGGSslqyPNIFWINPKTGELQLITQADHETTSVYILTVEATN 264
Cdd:cd11304    1 SYEVSVPENAPPGTVVLTVSATDPDSGENgEVTYSIVSGNE----DGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATD 76

                         90       100
                 ....*....|....*....|.
gi 755541461 265 GED---RSSVTVTVNILGEND 282
Cdd:cd11304   77 GGGpplSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
187-278 5.62e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 70.41  E-value: 5.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755541461  187 YVFDVPERRPARTQIGQVRATDADF-PRTPVVYSVSRGGSSlqypNIFWINPKTGELQLITQADHETTSVYILTVEATN- 264
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLgPNGRIFYSILGGGPG----GNFRIDPDTGDISTTKPLDRESIGEYELTVEATDs 76

                          90
                  ....*....|....*.
gi 755541461  265 -GEDRSSV-TVTVNIL 278
Cdd:pfam00028  77 gGPPLSSTaTVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 205-285 1.22e-12

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 63.52  E-value: 1.22e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755541461   205 RATDADFPR-TPVVYSVSRGGsslqYPNIFWINPKTGELQLITQADHETTSVYILTVEATNGEDR---SSVTVTVNILGE 280
Cdd:smart00112   1 SATDADSGEnGKVTYSILSGN----DDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPplsSTATVTITVLDV 76


                   ....*
gi 755541461   281 NDEKP 285
Cdd:smart00112  77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 292-400 1.84e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 55.01  E-value: 1.84e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755541461 292 YFMAIPVDLKVGTNIqnFKLTCTDLDSSP-SSFRYSIGSGNINNHFTFSPNAGsnitRLLLASRFDYSSLDTvwdYQLLV 370
Cdd:cd11304    2 YEVSVPENAPPGTVV--LTVSATDPDSGEnGEVTYSIVSGNEDGLFSIDPSTG----EITTAKPLDREEQSS---YTLTV 72

                         90       100       110
                 ....*....|....*....|....*....|
gi 755541461 371 HITDDNLLSGSTkakalvetgTVTLSVKVI 400
Cdd:cd11304   73 TATDGGGPPLSS---------TATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 8-62 4.48e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 48.08  E-value: 4.48e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755541461   8 PVTGTIQVARRLDRDagelrQNPIISLEVRVRDRPSGGQENRMQITFIVEDINDN 62
Cdd:cd11304   49 PSTGEITTAKPLDRE-----EQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 8-63 8.00e-07

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 46.96  E-value: 8.00e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 755541461     8 PVTGTIQVARRLDRDagelrQNPIISLEVRVRDRPSGGQENRMQITFIVEDINDNP 63
Cdd:smart00112  30 PETGEITTTKPLDRE-----EQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80
Cadherin pfam00028
Cadherin domain;
292-400 1.15e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.83  E-value: 1.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755541461  292 YFMAIPVDLKVGTNIQNfkLTCTDLDSSP-SSFRYSIGSGNINNHFTFSPNAGSnitrLLLASRFDYSSLDTvwdYQLLV 370
Cdd:pfam00028   1 YSASVPENAPVGTEVLT--VTATDPDLGPnGRIFYSILGGGPGGNFRIDPDTGD----ISTTKPLDRESIGE---YELTV 71

                          90       100       110
                  ....*....|....*....|....*....|
gi 755541461  371 HITDdnllsGSTKAKalveTGTVTLSVKVI 400
Cdd:pfam00028  72 EATD-----SGGPPL----SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
8-57 1.36e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.05  E-value: 1.36e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 755541461    8 PVTGTIQVARRLDRDagelrQNPIISLEVRVRDRPSGGQENRMQITFIVE 57
Cdd:pfam00028  48 PDTGDISTTKPLDRE-----SIGEYELTVEATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 314-400 2.32e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 36.94  E-value: 2.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755541461   314 TDLDSSPSS-FRYSIGSGNINNHFTFSPNAGsnitRLLLASRFDYSSLDTvwdYQLLVHITDdnllsGSTKAKalveTGT 392
Cdd:smart00112   3 TDADSGENGkVTYSILSGNDDGLFSIDPETG----EITTTKPLDREEQPE---YTLTVEATD-----GGGPPL----SST 66


                   ....*...
gi 755541461   393 VTLSVKVI 400
Cdd:smart00112  67 ATVTITVL 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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