NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|755515311|ref|XP_011239348|]
View 

nuclear respiratory factor 1 isoform X1 [Mus musculus]

Protein Classification

MoaD/ThiS family protein; Ubl5/Hub1 family ubiquitin-like protein( domain architecture ID 13769113)

MoaD/ThiS family protein is a ubiquitin-like protein, may be involved in sulfur transfer| Ubl5/Hub1 family ubiquitin-like protein similar to Saccharomyces cerevisiae Hub1 that plays a role in splice-site usage and alternative splicing

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Nrf1_DNA-bind pfam10491
NLS-binding and DNA-binding and dimerization domains of Nrf1; In Drosophila, the erect wing ...
 87-295 4.59e-161

NLS-binding and DNA-binding and dimerization domains of Nrf1; In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0, there is also an NLS domain at 88-116, and a DNA binding and dimerization domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity.


:

Pssm-ID: 463112  Cd Length: 213  Bit Score: 456.89  E-value: 4.59e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755515311   87 GPVGMAAAAAVATGKKRKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLEN 166
Cdd:pfam10491   1 GPVGVAAAAAIATGKKRKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAVVLCCSPSKPNPVFKVFGAAPLEN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755515311  167 VVRKYKSMILEDLESALAEHAPAPQEVNS----ELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCK 242
Cdd:pfam10491  81 VIRNYKSVILQDLESALAEQAPPPQEVENpglfELPPLVIDGIPTPVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCR 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 755515311  243 PIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCYKQHGREDLLYAFE 295
Cdd:pfam10491 161 PVWWPKDVPWANVRSDVRTEEQKQRVSWTQALRTIVKNCYKHHGREDLLYAFE 213
TGS_YchF_OLA1 cd04867
TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins; The YchF/Ola1 ...
 462-537 4.78e-44

TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins; The YchF/Ola1 family includes bacterial ribosome-binding ATPase YchF as well as its human homolog Obg-like ATPase 1 (OLA1), both of which belong to the Obg family of GTPases, and are novel ATPases that bind and hydrolyze ATP more efficiently than GTP. They have been associated with various cellular processes and pathologies, including DNA repair, tumorigenesis, and apoptosis, in addition to the regulation of the oxidative stress response. OLA1 is also termed DNA damage-regulated overexpressed in cancer 45 (DOC45), or GTP-binding protein 9 (GTPBP9). It is over-expressed in several human malignancies, including cancers of the colon, rectum, ovary, lung, stomach, and uterus. It is linked to the cellular stress response and tumorigenesis, and may also serve as a valuable tumor marker. Members in this family contain a central Obg-type G (guanine nucleotide-binding) domain, flanked by a coiled-coil domain and this TGS (ThrRS, GTPase, SpoT) domain of unknown function.


:

Pssm-ID: 340516 [Multi-domain]  Cd Length: 85  Bit Score: 150.76  E-value: 4.78e-44
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755515311 462 GPDGVHAWTISKAVTAPQAAGKIHTDFGKGFIMAEVMKDEDLKEESSENAAKAAGKYKQQGRAYVVEDGDIIFFKF 537
Cdd:cd04867   10 GPDEVRAWTIRKGTKAPQAAGVIHTDFEKGFIRAEVIKYDDLKELGSEAAAKEAGKYRQEGKDYVVQDGDIIHFKF 85
 
Name Accession Description Interval E-value
Nrf1_DNA-bind pfam10491
NLS-binding and DNA-binding and dimerization domains of Nrf1; In Drosophila, the erect wing ...
 87-295 4.59e-161

NLS-binding and DNA-binding and dimerization domains of Nrf1; In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0, there is also an NLS domain at 88-116, and a DNA binding and dimerization domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity.


Pssm-ID: 463112  Cd Length: 213  Bit Score: 456.89  E-value: 4.59e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755515311   87 GPVGMAAAAAVATGKKRKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLEN 166
Cdd:pfam10491   1 GPVGVAAAAAIATGKKRKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAVVLCCSPSKPNPVFKVFGAAPLEN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755515311  167 VVRKYKSMILEDLESALAEHAPAPQEVNS----ELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCK 242
Cdd:pfam10491  81 VIRNYKSVILQDLESALAEQAPPPQEVENpglfELPPLVIDGIPTPVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCR 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 755515311  243 PIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCYKQHGREDLLYAFE 295
Cdd:pfam10491 161 PVWWPKDVPWANVRSDVRTEEQKQRVSWTQALRTIVKNCYKHHGREDLLYAFE 213
TGS_YchF_OLA1 cd04867
TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins; The YchF/Ola1 ...
 462-537 4.78e-44

TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins; The YchF/Ola1 family includes bacterial ribosome-binding ATPase YchF as well as its human homolog Obg-like ATPase 1 (OLA1), both of which belong to the Obg family of GTPases, and are novel ATPases that bind and hydrolyze ATP more efficiently than GTP. They have been associated with various cellular processes and pathologies, including DNA repair, tumorigenesis, and apoptosis, in addition to the regulation of the oxidative stress response. OLA1 is also termed DNA damage-regulated overexpressed in cancer 45 (DOC45), or GTP-binding protein 9 (GTPBP9). It is over-expressed in several human malignancies, including cancers of the colon, rectum, ovary, lung, stomach, and uterus. It is linked to the cellular stress response and tumorigenesis, and may also serve as a valuable tumor marker. Members in this family contain a central Obg-type G (guanine nucleotide-binding) domain, flanked by a coiled-coil domain and this TGS (ThrRS, GTPase, SpoT) domain of unknown function.


Pssm-ID: 340516 [Multi-domain]  Cd Length: 85  Bit Score: 150.76  E-value: 4.78e-44
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755515311 462 GPDGVHAWTISKAVTAPQAAGKIHTDFGKGFIMAEVMKDEDLKEESSENAAKAAGKYKQQGRAYVVEDGDIIFFKF 537
Cdd:cd04867   10 GPDEVRAWTIRKGTKAPQAAGVIHTDFEKGFIRAEVIKYDDLKELGSEAAAKEAGKYRQEGKDYVVQDGDIIHFKF 85
YchF-GTPase_C pfam06071
Protein of unknown function (DUF933); This domain is found at the C terminus of the YchF ...
 462-536 6.36e-43

Protein of unknown function (DUF933); This domain is found at the C terminus of the YchF GTP-binding protein and is possibly related to the ubiquitin-like and MoaD/ThiS superfamilies.


Pssm-ID: 461819 [Multi-domain]  Cd Length: 82  Bit Score: 147.50  E-value: 6.36e-43
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755515311  462 GPDGVHAWTISKAVTAPQAAGKIHTDFGKGFIMAEVMKDEDLKEESSENAAKAAGKYKQQGRAYVVEDGDIIFFK 536
Cdd:pfam06071   8 GPKEVRAWTIRKGTTAPQAAGVIHTDFEKGFIRAEVISYDDLIEYGSEAAAKEAGKLRLEGKDYVVQDGDIIHFR 82
PTZ00258 PTZ00258
GTP-binding protein; Provisional
 462-540 1.34e-38

GTP-binding protein; Provisional


Pssm-ID: 240334 [Multi-domain]  Cd Length: 390  Bit Score: 145.47  E-value: 1.34e-38
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755515311 462 GPDGVHAWTISKAVTAPQAAGKIHTDFGKGFIMAEVMKDEDLKEESSENAAKAAGKYKQQGRAYVVEDGDIIFFKFNSP 540
Cdd:PTZ00258 311 GPDEVRCWTIQKGTKAPQAAGVIHSDFEKGFICAEVMKYEDFLELGSEAAVKAEGKYRQEGKDYVVQDGDIIFFKFNVS 389
GTP1 COG0012
Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis] ...
 462-538 6.27e-34

Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439783 [Multi-domain]  Cd Length: 362  Bit Score: 132.07  E-value: 6.27e-34
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755515311 462 GPDGVHAWTISKAVTAPQAAGKIHTDFGKGFIMAEVMKDEDLKEESSENAAKAAGKYKQQGRAYVVEDGDIIFFKFN 538
Cdd:COG0012  285 GPKEVRAWTIKKGTTAPQAAGVIHTDFERGFIRAEVISYDDLIAYGSEAAAKEAGKLRLEGKDYVVQDGDVIHFRFN 361
TIGR00092 TIGR00092
GTP-binding protein YchF; This predicted GTP-binding protein is found in a single copy in ...
 462-538 8.04e-19

GTP-binding protein YchF; This predicted GTP-binding protein is found in a single copy in every complete bacterial genome, and is found in Eukaryotes. A more distantly related protein, separated from this model, is found in the archaea. It is known to bind GTP and double-stranded nucleic acid. It is suggested to belong to a nucleoprotein complex and act as a translation factor. [Unknown function, General]


Pssm-ID: 129200 [Multi-domain]  Cd Length: 368  Bit Score: 88.29  E-value: 8.04e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755515311  462 GPDGVH-AWTISKAVTAPQAAGKIHTDFGKGFIMAEVMKDEDLKEESSENAAKAAGKYKQQGRAYVVEDGDIIFFKFN 538
Cdd:TIGR00092 290 GGKEEVrAWTRKGGWAAPQAAGIIHTDFETGFIAAEVISWDDFIYKKSSQGAKKGGLMRLEGKYYVVDDGDVLFFAFN 367
 
Name Accession Description Interval E-value
Nrf1_DNA-bind pfam10491
NLS-binding and DNA-binding and dimerization domains of Nrf1; In Drosophila, the erect wing ...
 87-295 4.59e-161

NLS-binding and DNA-binding and dimerization domains of Nrf1; In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0, there is also an NLS domain at 88-116, and a DNA binding and dimerization domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity.


Pssm-ID: 463112  Cd Length: 213  Bit Score: 456.89  E-value: 4.59e-161
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755515311   87 GPVGMAAAAAVATGKKRKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAIVLCISPSKPNPVFKVFGAAPLEN 166
Cdd:pfam10491   1 GPVGVAAAAAIATGKKRKRPHVFESNPSIRKRQQTRLLRKLRATLDEYTTRVGQQAVVLCCSPSKPNPVFKVFGAAPLEN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755515311  167 VVRKYKSMILEDLESALAEHAPAPQEVNS----ELPPLTIDGIPVSVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCK 242
Cdd:pfam10491  81 VIRNYKSVILQDLESALAEQAPPPQEVENpglfELPPLVIDGIPTPVDKMTQAQLRAFIPEMLKYSTGRGKPGWGKESCR 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 755515311  243 PIWWPEDIPWANVRSDVRTEEQKQRVSWTQALRTIVKNCYKQHGREDLLYAFE 295
Cdd:pfam10491 161 PVWWPKDVPWANVRSDVRTEEQKQRVSWTQALRTIVKNCYKHHGREDLLYAFE 213
TGS_YchF_OLA1 cd04867
TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins; The YchF/Ola1 ...
 462-537 4.78e-44

TGS (ThrRS, GTPase and SpoT) domain found in the YchF/OLA1 family proteins; The YchF/Ola1 family includes bacterial ribosome-binding ATPase YchF as well as its human homolog Obg-like ATPase 1 (OLA1), both of which belong to the Obg family of GTPases, and are novel ATPases that bind and hydrolyze ATP more efficiently than GTP. They have been associated with various cellular processes and pathologies, including DNA repair, tumorigenesis, and apoptosis, in addition to the regulation of the oxidative stress response. OLA1 is also termed DNA damage-regulated overexpressed in cancer 45 (DOC45), or GTP-binding protein 9 (GTPBP9). It is over-expressed in several human malignancies, including cancers of the colon, rectum, ovary, lung, stomach, and uterus. It is linked to the cellular stress response and tumorigenesis, and may also serve as a valuable tumor marker. Members in this family contain a central Obg-type G (guanine nucleotide-binding) domain, flanked by a coiled-coil domain and this TGS (ThrRS, GTPase, SpoT) domain of unknown function.


Pssm-ID: 340516 [Multi-domain]  Cd Length: 85  Bit Score: 150.76  E-value: 4.78e-44
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755515311 462 GPDGVHAWTISKAVTAPQAAGKIHTDFGKGFIMAEVMKDEDLKEESSENAAKAAGKYKQQGRAYVVEDGDIIFFKF 537
Cdd:cd04867   10 GPDEVRAWTIRKGTKAPQAAGVIHTDFEKGFIRAEVIKYDDLKELGSEAAAKEAGKYRQEGKDYVVQDGDIIHFKF 85
YchF-GTPase_C pfam06071
Protein of unknown function (DUF933); This domain is found at the C terminus of the YchF ...
 462-536 6.36e-43

Protein of unknown function (DUF933); This domain is found at the C terminus of the YchF GTP-binding protein and is possibly related to the ubiquitin-like and MoaD/ThiS superfamilies.


Pssm-ID: 461819 [Multi-domain]  Cd Length: 82  Bit Score: 147.50  E-value: 6.36e-43
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755515311  462 GPDGVHAWTISKAVTAPQAAGKIHTDFGKGFIMAEVMKDEDLKEESSENAAKAAGKYKQQGRAYVVEDGDIIFFK 536
Cdd:pfam06071   8 GPKEVRAWTIRKGTTAPQAAGVIHTDFEKGFIRAEVISYDDLIEYGSEAAAKEAGKLRLEGKDYVVQDGDIIHFR 82
PTZ00258 PTZ00258
GTP-binding protein; Provisional
 462-540 1.34e-38

GTP-binding protein; Provisional


Pssm-ID: 240334 [Multi-domain]  Cd Length: 390  Bit Score: 145.47  E-value: 1.34e-38
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755515311 462 GPDGVHAWTISKAVTAPQAAGKIHTDFGKGFIMAEVMKDEDLKEESSENAAKAAGKYKQQGRAYVVEDGDIIFFKFNSP 540
Cdd:PTZ00258 311 GPDEVRCWTIQKGTKAPQAAGVIHSDFEKGFICAEVMKYEDFLELGSEAAVKAEGKYRQEGKDYVVQDGDIIFFKFNVS 389
GTP1 COG0012
Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis] ...
 462-538 6.27e-34

Ribosome-binding ATPase YchF, GTP1/OBG family [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439783 [Multi-domain]  Cd Length: 362  Bit Score: 132.07  E-value: 6.27e-34
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755515311 462 GPDGVHAWTISKAVTAPQAAGKIHTDFGKGFIMAEVMKDEDLKEESSENAAKAAGKYKQQGRAYVVEDGDIIFFKFN 538
Cdd:COG0012  285 GPKEVRAWTIKKGTTAPQAAGVIHTDFERGFIRAEVISYDDLIAYGSEAAAKEAGKLRLEGKDYVVQDGDVIHFRFN 361
TIGR00092 TIGR00092
GTP-binding protein YchF; This predicted GTP-binding protein is found in a single copy in ...
 462-538 8.04e-19

GTP-binding protein YchF; This predicted GTP-binding protein is found in a single copy in every complete bacterial genome, and is found in Eukaryotes. A more distantly related protein, separated from this model, is found in the archaea. It is known to bind GTP and double-stranded nucleic acid. It is suggested to belong to a nucleoprotein complex and act as a translation factor. [Unknown function, General]


Pssm-ID: 129200 [Multi-domain]  Cd Length: 368  Bit Score: 88.29  E-value: 8.04e-19
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755515311  462 GPDGVH-AWTISKAVTAPQAAGKIHTDFGKGFIMAEVMKDEDLKEESSENAAKAAGKYKQQGRAYVVEDGDIIFFKFN 538
Cdd:TIGR00092 290 GGKEEVrAWTRKGGWAAPQAAGIIHTDFETGFIAAEVISWDDFIYKKSSQGAKKGGLMRLEGKYYVVDDGDVLFFAFN 367
TGS_Obg cd04938
TGS (ThrRS, GTPase and SpoT) domain found in the Obg protein family; The Obg family of GTPases ...
 461-536 2.54e-07

TGS (ThrRS, GTPase and SpoT) domain found in the Obg protein family; The Obg family of GTPases function has been implicated in cellular processes as diverse as sporulation, stress response, control of DNA replication, and ribosome assembly. It consists of several subfamilies such as DRG and YchF with TGS domain. The TGS domain is named after the various RNA-binding multidomain ThrRS, GTPase, and SpoT/RelA proteins in which this domain occurs. The TGS domain of Obg-like GTPases such as those present in DRG (developmentally regulated GTP-binding protein), and GTP-binding proteins Ygr210 and YchF has a beta-grasp ubiquitin-like fold, a common structure involved in protein-protein interactions.


Pssm-ID: 340517 [Multi-domain]  Cd Length: 77  Bit Score: 48.21  E-value: 2.54e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755515311 461 NGPDGVHAWTISKAVTAPQAAGKIHTDFGKGFIMAEVmkdedlkeessenaakaAGKYKQQGRAYVVEDGDIIFFK 536
Cdd:cd04938   19 GNSVFRDCVLVKKGTTVKDFANKIHTDLEKGFINAEG-----------------IGGRRLEGEDYILQDNDVVKFT 77
TGS cd01616
TGS (ThrRS, GTPase and SpoT) domain structurally similar to a beta-grasp ubiquitin-like fold; ...
 462-535 2.16e-05

TGS (ThrRS, GTPase and SpoT) domain structurally similar to a beta-grasp ubiquitin-like fold; This family includes eukaryotic and some bacterial threonyl-tRNA synthetases (ThrRSs), a distinct Obg family GTPases, and guanosine polyphosphate hydrolase (SpoT) and synthetase (RelA), which are involved in stringent response in bacteria, as well as uridine kinase (UDK) from Thermotogales. All family members contain a TGS domain named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs. It is a small domain with a beta-grasp ubiquitin-like fold, a common structure involved in protein-protein interactions. The functions of the TGS domain remains unclear, but its presence in two types of regulatory proteins (the GTPases and guanosine polyphosphate phosphohydrolases/synthetases) suggests a ligand (most likely nucleotide)-binding, with a regulatory role.


Pssm-ID: 340455 [Multi-domain]  Cd Length: 61  Bit Score: 42.21  E-value: 2.16e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755515311 462 GPDGVHAWTISKAVTAPQAAGKIHTDFGKGFIMAEVMkdedlkeessenaAKAAGKYkqqgraYVVEDGDIIFF 535
Cdd:cd01616    6 GKTPGTVFVMNKGATAYSCAMHLHEDYCRKSILALVD-------------GQLWDMY------YPLTKGDEIKF 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH