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Conserved domains on  [gi|688554583|ref|XP_009299686|]
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bromodomain and WD repeat-containing protein 3 isoform X2 [Danio rerio]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077624)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 1294-1412 5.52e-72

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99928  Cd Length: 119  Bit Score: 235.82  E-value: 5.52e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1294 LDINAWHKQCKDLVRRMIVSSDSEPFRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAY 1373
Cdd:cd05496     1 YDESDWKKQCKELVNLMWDCEDSEPFRQPVDLLKYPDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSY 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 688554583 1374 TPNKKSRIYSMTLSLSAFFENQIIPIISDYKSAVQNQRR 1412
Cdd:cd05496    81 TPNKRSRIYSMTLRLSALFEEHIKKIISDWKSALKRNEK 119
WD40 COG2319
WD40 repeat [General function prediction only];
175-497 2.54e-61

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 216.32  E-value: 2.54e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  175 RRILGHLSSVYCVAFDRTGRRIFTGSDDCLVKIWATDNGRLLATLRGHAAEISDMTVNFENTLLASASCDKIVRVWCLRT 254
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  255 CAPVAVLQGHTASITSIQFSPsalgSSRFLATTGADGMVCFWQWNSfsmkfvDKPVKFMERSRPGVqiSCSSFSSGGLFL 334
Cdd:COG2319   194 GKLLRTLTGHTGAVRSVAFSP----DGKLLASGSADGTVRLWDLAT------GKLLRTLTGHSGSV--RSVAFSPDGRLL 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  335 ATGGTDHMIRVYYLGTEMPVKFsdLDSHTDKVVAIQFcnNTDSLRFVSGSRDGTARIWhyqqqewkstvlDMTTRLPGsA 414
Cdd:COG2319   262 ASGSADGTVRLWDLATGELLRT--LTGHSGGVNSVAF--SPDGKLLASGSDDGTVRLW------------DLATGKLL-R 324

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  415 VISGDDKStklvVTMVAWDRCDRSIITAVSNCLLKVWNSTNGQLLHVLSGHDDEVFVLEAHPfDSRILLSAGHDGNIYVW 494
Cdd:COG2319   325 TLTGHTGA----VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLW 399


                  ...
gi 688554583  495 DLS 497
Cdd:COG2319   400 DLA 402
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 1126-1241 1.00e-44

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


:

Pssm-ID: 99958  Cd Length: 128  Bit Score: 158.27  E-value: 1.00e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1126 LYSPQEGEWGL--------HTRDEECERVITAIDQLLT---LDVAKAFSNPVNLR-EYPLYCTVVAYLTDLSTIRTRLVH 1193
Cdd:cd05529     1 LYNPLSSEWELfdpgweqpHIRDEERERLISGLDKLLLslqLEIAEYFEYPVDLRaWYPDYWNRVPVPMDLETIRSRLEN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 688554583 1194 RFYRRISALMWEVRYIEHNARTFNEPQSPIVTAAKTVSDVLLRFIRDQ 1241
Cdd:cd05529    81 RYYRSLEALRHDVRLILSNAETFNEPNSEIAKKAKRLSDWLLRILSSL 128
 
Name Accession Description Interval E-value
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 1294-1412 5.52e-72

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 235.82  E-value: 5.52e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1294 LDINAWHKQCKDLVRRMIVSSDSEPFRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAY 1373
Cdd:cd05496     1 YDESDWKKQCKELVNLMWDCEDSEPFRQPVDLLKYPDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSY 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 688554583 1374 TPNKKSRIYSMTLSLSAFFENQIIPIISDYKSAVQNQRR 1412
Cdd:cd05496    81 TPNKRSRIYSMTLRLSALFEEHIKKIISDWKSALKRNEK 119
WD40 COG2319
WD40 repeat [General function prediction only];
175-497 2.54e-61

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 216.32  E-value: 2.54e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  175 RRILGHLSSVYCVAFDRTGRRIFTGSDDCLVKIWATDNGRLLATLRGHAAEISDMTVNFENTLLASASCDKIVRVWCLRT 254
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  255 CAPVAVLQGHTASITSIQFSPsalgSSRFLATTGADGMVCFWQWNSfsmkfvDKPVKFMERSRPGVqiSCSSFSSGGLFL 334
Cdd:COG2319   194 GKLLRTLTGHTGAVRSVAFSP----DGKLLASGSADGTVRLWDLAT------GKLLRTLTGHSGSV--RSVAFSPDGRLL 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  335 ATGGTDHMIRVYYLGTEMPVKFsdLDSHTDKVVAIQFcnNTDSLRFVSGSRDGTARIWhyqqqewkstvlDMTTRLPGsA 414
Cdd:COG2319   262 ASGSADGTVRLWDLATGELLRT--LTGHSGGVNSVAF--SPDGKLLASGSDDGTVRLW------------DLATGKLL-R 324

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  415 VISGDDKStklvVTMVAWDRCDRSIITAVSNCLLKVWNSTNGQLLHVLSGHDDEVFVLEAHPfDSRILLSAGHDGNIYVW 494
Cdd:COG2319   325 TLTGHTGA----VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLW 399


                  ...
gi 688554583  495 DLS 497
Cdd:COG2319   400 DLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 173-495 7.26e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 199.48  E-value: 7.26e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  173 MHRRILGHLSSVYCVAFDRTGRRIFTGSDDCLVKIWATDNGRLLATLRGHAAEISDMTVNFENTLLASASCDKIVRVWCL 252
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  253 RTCAPVAVLQGHTASITSIQFSPsalgSSRFLATTGADGMVCFWQWNSFSMKFV----DKPVKfmersrpgvqisCSSFS 328
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSP----DGRILSSSSRDKTIKVWDVETGKCLTTlrghTDWVN------------SVAFS 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  329 SGGLFLATGGTDHMIRVYYLGTEMPVKFsdLDSHTDKVVAIQFCNntDSLRFVSGSRDGTARIWHYQQQEWKstvldmtt 408
Cdd:cd00200   145 PDGTFVASSSQDGTIKLWDLRTGKCVAT--LTGHTGEVNSVAFSP--DGEKLLSSSSDGTIKLWDLSTGKCL-------- 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  409 rlpgsAVISGDDKStklvVTMVAWDRCDRSIITAVSNCLLKVWNSTNGQLLHVLSGHDDEVFVLEAHPfDSRILLSAGHD 488
Cdd:cd00200   213 -----GTLRGHENG----VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSAD 282


                  ....*..
gi 688554583  489 GNIYVWD 495
Cdd:cd00200   283 GTIRIWD 289
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 1126-1241 1.00e-44

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 158.27  E-value: 1.00e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1126 LYSPQEGEWGL--------HTRDEECERVITAIDQLLT---LDVAKAFSNPVNLR-EYPLYCTVVAYLTDLSTIRTRLVH 1193
Cdd:cd05529     1 LYNPLSSEWELfdpgweqpHIRDEERERLISGLDKLLLslqLEIAEYFEYPVDLRaWYPDYWNRVPVPMDLETIRSRLEN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 688554583 1194 RFYRRISALMWEVRYIEHNARTFNEPQSPIVTAAKTVSDVLLRFIRDQ 1241
Cdd:cd05529    81 RYYRSLEALRHDVRLILSNAETFNEPNSEIAKKAKRLSDWLLRILSSL 128
BROMO smart00297
bromo domain;
1295-1396 7.50e-22

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 91.96  E-value: 7.50e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583   1295 DINAWHKQCKDLVRRMIVSSDSEPFRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYT 1374
Cdd:smart00297    4 LQKKLQELLKAVLDKLDSHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTYN 83

                            90       100
                    ....*....|....*....|..
gi 688554583   1375 PnKKSRIYSMTLSLSAFFENQI 1396
Cdd:smart00297   84 G-PDSEVYKDAKKLEKFFEKKL 104
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 1143-1229 2.13e-17

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 78.51  E-value: 2.13e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  1143 CERVItaiDQLLTLDVAKAFSNPVNLREYPLYCTVVAYLTDLSTIRTRLVHRFYRRISALMWEVRYIEHNARTFNEPQSP 1222
Cdd:pfam00439    1 CLEIL---DKLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSV 77


                   ....*..
gi 688554583  1223 IVTAAKT 1229
Cdd:pfam00439   78 IYKAAEK 84
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 1303-1382 1.71e-15

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 73.12  E-value: 1.71e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  1303 CKDLVRRMIVSSDSEPFRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYtpNKK-SRI 1381
Cdd:pfam00439    1 CLEILDKLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTY--NGPgSVI 78


                   .
gi 688554583  1382 Y 1382
Cdd:pfam00439   79 Y 79
BROMO smart00297
bromo domain;
1150-1240 2.32e-13

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 67.69  E-value: 2.32e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583   1150 IDQLLTLDVAKAFSNPVNLREYPLYCTVVAYLTDLSTIRTRLVHRFYRRISALMWEVRYIEHNARTFNEPQSPIVTAAKT 1229
Cdd:smart00297   16 LDKLDSHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTYNGPDSEVYKDAKK 95

                            90
                    ....*....|.
gi 688554583   1230 VSDVLLRFIRD 1240
Cdd:smart00297   96 LEKFFEKKLRE 106
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 1013-1379 5.83e-09

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 60.20  E-value: 5.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1013 NESFSLKYHDMPDVIDFLVLqqfYNEAKERNwqpgqrfrSIIDDAWWFGSLECQEPFESEYPDSLFQCYIV--RWDNGER 1090
Cdd:COG5076    46 KNLFQKQLKRMPKEYITSIV---DDREPGSM--------ANVNDDLENVGGITYSPFEKNRPESLRFDEIVflAIESVTP 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1091 EKMSpwdiepipeEAPLPEEDGDSVPV-TEDELQALLYspqegewglhtrDEECERVITAIDQLLTLDVAK---AFSNPV 1166
Cdd:COG5076   115 ESGL---------GSLLMAHLKTSVKKrKTPKIEDELL------------YADNKAIAKFKKQLFLRDGRFlssIFLGLP 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1167 NLREYPLYCTVVAYLTDLSTIRTRLVHRFYR------RISALMWEvryiehNARTFNEPQSPIVTAAKTVSDVLLRFIRD 1240
Cdd:COG5076   174 SKREYPDYYEIIKSPMDLLTIQKKLKNGRYKsfeefvSDLNLMFD------NCKLYNGPDSSVYVDAKELEKYFLKLIEE 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1241 QnCTDILDLYnkmksefsseedeeetvdvdsdtpgtstgQRRSNSTPQKRGVVLdINAwhkqckdlvrrMIVSSDSEPFR 1320
Cdd:COG5076   248 I-PEEMLELS-----------------------------IKPGREEREERESVL-ITN-----------SQAHVGAWPFL 285

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 688554583 1321 QPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSN----SKAYTPNKKS 1379
Cdd:COG5076   286 RPVSDEEVPDYYKDIRDPMDLSTKELKLRNNYYRPEETFVRDAKLFFDNcvmyNGEVTDYYKN 348
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 455-495 7.66e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 7.66e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 688554583    455 NGQLLHVLSGHDDEVFVLEAHPfDSRILLSAGHDGNIYVWD 495
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
175-208 2.09e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 2.09e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 688554583   175 RRILGHLSSVYCVAFDRTGRRIFTGSDDCLVKIW 208
Cdd:pfam00400    5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 182-392 3.52e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.01  E-value: 3.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  182 SSVYC-VAFDRTGRRIFTGSDDCLVKIWATD----NGRLL----ATLRGHAaEISDMTVN-FENTLLASASCDKIVRVWC 251
Cdd:PLN00181  483 SNLVCaIGFDRDGEFFATAGVNKKIKIFECEsiikDGRDIhypvVELASRS-KLSGICWNsYIKSQVASSNFEGVVQVWD 561

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  252 LRTCAPVAVLQGHTASITSIQFSPSalgSSRFLATTGADGMVCFWQWNS-FSMKFVdkpvkfmersRPGVQISCSSF-SS 329
Cdd:PLN00181  562 VARSQLVTEMKEHEKRVWSIDYSSA---DPTLLASGSDDGSVKLWSINQgVSIGTI----------KTKANICCVQFpSE 628

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 688554583  330 GGLFLATGGTDHmiRVYYLGTEMP-VKFSDLDSHTDKVVAIQFcnnTDSLRFVSGSRDGTARIW 392
Cdd:PLN00181  629 SGRSLAFGSADH--KVYYYDLRNPkLPLCTMIGHSKTVSYVRF---VDSSTLVSSSTDNTLKLW 687
 
Name Accession Description Interval E-value
Bromo_WDR9_II cd05496
Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 1294-1412 5.52e-72

Bromodomain; WDR9 repeat II_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99928  Cd Length: 119  Bit Score: 235.82  E-value: 5.52e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1294 LDINAWHKQCKDLVRRMIVSSDSEPFRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAY 1373
Cdd:cd05496     1 YDESDWKKQCKELVNLMWDCEDSEPFRQPVDLLKYPDYRDIIDTPMDLGTVKETLFGGNYDDPMEFAKDVRLIFSNSKSY 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 688554583 1374 TPNKKSRIYSMTLSLSAFFENQIIPIISDYKSAVQNQRR 1412
Cdd:cd05496    81 TPNKRSRIYSMTLRLSALFEEHIKKIISDWKSALKRNEK 119
WD40 COG2319
WD40 repeat [General function prediction only];
175-497 2.54e-61

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 216.32  E-value: 2.54e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  175 RRILGHLSSVYCVAFDRTGRRIFTGSDDCLVKIWATDNGRLLATLRGHAAEISDMTVNFENTLLASASCDKIVRVWCLRT 254
Cdd:COG2319   114 RTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  255 CAPVAVLQGHTASITSIQFSPsalgSSRFLATTGADGMVCFWQWNSfsmkfvDKPVKFMERSRPGVqiSCSSFSSGGLFL 334
Cdd:COG2319   194 GKLLRTLTGHTGAVRSVAFSP----DGKLLASGSADGTVRLWDLAT------GKLLRTLTGHSGSV--RSVAFSPDGRLL 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  335 ATGGTDHMIRVYYLGTEMPVKFsdLDSHTDKVVAIQFcnNTDSLRFVSGSRDGTARIWhyqqqewkstvlDMTTRLPGsA 414
Cdd:COG2319   262 ASGSADGTVRLWDLATGELLRT--LTGHSGGVNSVAF--SPDGKLLASGSDDGTVRLW------------DLATGKLL-R 324

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  415 VISGDDKStklvVTMVAWDRCDRSIITAVSNCLLKVWNSTNGQLLHVLSGHDDEVFVLEAHPfDSRILLSAGHDGNIYVW 494
Cdd:COG2319   325 TLTGHTGA----VRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLW 399


                  ...
gi 688554583  495 DLS 497
Cdd:COG2319   400 DLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
175-530 3.73e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 212.85  E-value: 3.73e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  175 RRILGHLSSVYCVAFDRTGRRIFTGSDDCLVKIWATDNGRLLATLRGHAAEISDMTVNFENTLLASASCDKIVRVWCLRT 254
Cdd:COG2319    72 ATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLAT 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  255 CAPVAVLQGHTASITSIQFSPsalgSSRFLATTGADGMVCFWQWNSfsmkfvDKPVKFMERSRPGVqiSCSSFSSGGLFL 334
Cdd:COG2319   152 GKLLRTLTGHSGAVTSVAFSP----DGKLLASGSDDGTVRLWDLAT------GKLLRTLTGHTGAV--RSVAFSPDGKLL 219

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  335 ATGGTDHMIRVYYLGTEMPVKFsdLDSHTDKVVAIQFcnNTDSLRFVSGSRDGTARIWHYQQQEWKSTvLDMTTRLPGSA 414
Cdd:COG2319   220 ASGSADGTVRLWDLATGKLLRT--LTGHSGSVRSVAF--SPDGRLLASGSADGTVRLWDLATGELLRT-LTGHSGGVNSV 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  415 VISGDdkstklvvtmvawdrcDRSIITAVSNCLLKVWNSTNGQLLHVLSGHDDEVFVLEAHPfDSRILLSAGHDGNIYVW 494
Cdd:COG2319   295 AFSPD----------------GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLW 357

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 688554583  495 DLSKGQKIRNFfnmiegQGH-GAVFDCKFSVDGQHFA 530
Cdd:COG2319   358 DLATGELLRTL------TGHtGAVTSVAFSPDGRTLA 388
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 173-495 7.26e-57

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 199.48  E-value: 7.26e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  173 MHRRILGHLSSVYCVAFDRTGRRIFTGSDDCLVKIWATDNGRLLATLRGHAAEISDMTVNFENTLLASASCDKIVRVWCL 252
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  253 RTCAPVAVLQGHTASITSIQFSPsalgSSRFLATTGADGMVCFWQWNSFSMKFV----DKPVKfmersrpgvqisCSSFS 328
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSP----DGRILSSSSRDKTIKVWDVETGKCLTTlrghTDWVN------------SVAFS 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  329 SGGLFLATGGTDHMIRVYYLGTEMPVKFsdLDSHTDKVVAIQFCNntDSLRFVSGSRDGTARIWHYQQQEWKstvldmtt 408
Cdd:cd00200   145 PDGTFVASSSQDGTIKLWDLRTGKCVAT--LTGHTGEVNSVAFSP--DGEKLLSSSSDGTIKLWDLSTGKCL-------- 212

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  409 rlpgsAVISGDDKStklvVTMVAWDRCDRSIITAVSNCLLKVWNSTNGQLLHVLSGHDDEVFVLEAHPfDSRILLSAGHD 488
Cdd:cd00200   213 -----GTLRGHENG----VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSAD 282


                  ....*..
gi 688554583  489 GNIYVWD 495
Cdd:cd00200   283 GTIRIWD 289
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 1126-1241 1.00e-44

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 158.27  E-value: 1.00e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1126 LYSPQEGEWGL--------HTRDEECERVITAIDQLLT---LDVAKAFSNPVNLR-EYPLYCTVVAYLTDLSTIRTRLVH 1193
Cdd:cd05529     1 LYNPLSSEWELfdpgweqpHIRDEERERLISGLDKLLLslqLEIAEYFEYPVDLRaWYPDYWNRVPVPMDLETIRSRLEN 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 688554583 1194 RFYRRISALMWEVRYIEHNARTFNEPQSPIVTAAKTVSDVLLRFIRDQ 1241
Cdd:cd05529    81 RYYRSLEALRHDVRLILSNAETFNEPNSEIAKKAKRLSDWLLRILSSL 128
WD40 COG2319
WD40 repeat [General function prediction only];
188-541 6.08e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.22  E-value: 6.08e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  188 AFDRTGRRIFTGSDDCLVKIWATDNGRLLATLRGHAAEISDMTVNFENTLLASASCDKIVRVWCLRTCAPVAVLQGHTAS 267
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  268 ITSIQFSPSAlgssRFLATTGADGMVCFWQwnsfsmkfVDKPVKFMERSRPGVQISCSSFSSGGLFLATGGTDHMIRVYY 347
Cdd:COG2319    81 VLSVAFSPDG----RLLASASADGTVRLWD--------LATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  348 LGTEMPVKfsDLDSHTDKVVAIQFcnNTDSLRFVSGSRDGTARIWHYQqqewkstvldmTTRLPgsAVISGDDKStklvV 427
Cdd:COG2319   149 LATGKLLR--TLTGHSGAVTSVAF--SPDGKLLASGSDDGTVRLWDLA-----------TGKLL--RTLTGHTGA----V 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  428 TMVAWDRCDRSIITAVSNCLLKVWNSTNGQLLHVLSGHDDEVFVLEAHPfDSRILLSAGHDGNIYVWDLSKGQKIRNFfn 507
Cdd:COG2319   208 RSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTL-- 284

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 688554583  508 miegQGH-GAVFDCKFSVDGQHFACTDSHGHLLIF 541
Cdd:COG2319   285 ----TGHsGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 172-392 3.11e-37

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 142.47  E-value: 3.11e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  172 KMHRRILGHLSSVYCVAFDRTGRRIFTGSDDCLVKIWATDNGRLLATLRGHAAEISDMTVNFENTLLASASCDKIVRVWC 251
Cdd:cd00200    84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  252 LRTCAPVAVLQGHTASITSIQFSPsalgSSRFLATTGADGMVCFWqwnSFSMKFVDKPVKFMERSrpgvqISCSSFSSGG 331
Cdd:cd00200   164 LRTGKCVATLTGHTGEVNSVAFSP----DGEKLLSSSSDGTIKLW---DLSTGKCLGTLRGHENG-----VNSVAFSPDG 231

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 688554583  332 LFLATGGTDHMIRVYYLGTEMPVKfsDLDSHTDKVVAIQFCNntDSLRFVSGSRDGTARIW 392
Cdd:cd00200   232 YLLASGSEDGTIRVWDLRTGECVQ--TLSGHTNSVTSLAWSP--DGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
175-350 1.37e-30

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.18  E-value: 1.37e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  175 RRILGHLSSVYCVAFDRTGRRIFTGSDDCLVKIWATDNGRLLATLRGHAAEISDMTVNFENTLLASASCDKIVRVWCLRT 254
Cdd:COG2319   240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLAT 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  255 CAPVAVLQGHTASITSIQFSPSalgsSRFLATTGADGMVCFWQWNSfsmkfvDKPVKFMERSRPGVqiSCSSFSSGGLFL 334
Cdd:COG2319   320 GKLLRTLTGHTGAVRSVAFSPD----GKTLASGSDDGTVRLWDLAT------GELLRTLTGHTGAV--TSVAFSPDGRTL 387

                         170
                  ....*....|....*.
gi 688554583  335 ATGGTDHMIRVYYLGT 350
Cdd:COG2319   388 ASGSADGTVRLWDLAT 403
Bromo_plant1 cd05506
Bromodomain, uncharacterized subfamily specific to plants. Might function as a global ...
 1299-1393 3.30e-26

Bromodomain, uncharacterized subfamily specific to plants. Might function as a global transcription factor. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99938  Cd Length: 99  Bit Score: 104.33  E-value: 3.30e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1299 WHKQCKDLVRRMIVSSDSEPFRQPVDLFTY--PDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYTPn 1376
Cdd:cd05506     1 VMKQCGTLLRKLMKHKWGWVFNAPVDVVALglPDYFDIIKKPMDLGTVKKKLEKGEYSSPEEFAADVRLTFANAMRYNP- 79

                          90
                  ....*....|....*..
gi 688554583 1377 KKSRIYSMTLSLSAFFE 1393
Cdd:cd05506    80 PGNDVHTMAKELLKIFE 96
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 1299-1396 9.53e-24

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 97.06  E-value: 9.53e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1299 WHKQCKDLVR--RMIVSSDSEPFRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYtpN 1376
Cdd:cd04369     1 LKKKLRSLLDalKKLKRDLSEPFLEPVDPKEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTY--N 78

                          90       100
                  ....*....|....*....|.
gi 688554583 1377 KK-SRIYSMTLSLSAFFENQI 1396
Cdd:cd04369    79 GPgSPIYKDAKKLEKLFEKLL 99
Bromo_cbp_like cd05495
Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase ...
 1315-1399 2.46e-22

Bromodomain, cbp_like subfamily. Cbp (CREB binding protein or CREBBP) is an acetyltransferase acting on histone, which gives a specific tag for transcriptional activation and also acetylates non-histone proteins. CREBBP binds specifically to phosphorylated CREB protein and augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99927  Cd Length: 108  Bit Score: 93.66  E-value: 2.46e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1315 DSEPFRQPVD--LFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYTPnKKSRIYSMTLSLSAFF 1392
Cdd:cd05495    21 ESLPFRQPVDpkLLGIPDYFDIVKNPMDLSTIRRKLDTGQYQDPWQYVDDVWLMFDNAWLYNR-KTSRVYKYCTKLAEVF 99


                  ....*..
gi 688554583 1393 ENQIIPI 1399
Cdd:cd05495   100 EQEIDPV 106
BROMO smart00297
bromo domain;
1295-1396 7.50e-22

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 91.96  E-value: 7.50e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583   1295 DINAWHKQCKDLVRRMIVSSDSEPFRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYT 1374
Cdd:smart00297    4 LQKKLQELLKAVLDKLDSHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTYN 83

                            90       100
                    ....*....|....*....|..
gi 688554583   1375 PnKKSRIYSMTLSLSAFFENQI 1396
Cdd:smart00297   84 G-PDSEVYKDAKKLEKFFEKKL 104
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 1299-1393 1.36e-20

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 88.10  E-value: 1.36e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1299 WHKQCKDLVRRMIVSSDSE---PFRQPVD--LFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAY 1373
Cdd:cd05498     1 QLKFCSGILKELFSKKHKAyawPFYKPVDpeALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKY 80

                          90       100
                  ....*....|....*....|
gi 688554583 1374 TPnKKSRIYSMTLSLSAFFE 1393
Cdd:cd05498    81 NP-PDHPVHAMARKLQDVFE 99
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 1300-1396 3.96e-18

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 81.06  E-value: 3.96e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1300 HKQCKDLVRRMIVSSDSEPFRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYTPnKKS 1379
Cdd:cd05509     3 YTQLKKVLDSLKNHKSAWPFLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNG-PDT 81

                          90
                  ....*....|....*..
gi 688554583 1380 RIYSMTLSLSAFFENQI 1396
Cdd:cd05509    82 EYYKCANKLEKFFWKKL 98
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 1315-1396 1.40e-17

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 79.66  E-value: 1.40e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1315 DSEPFRQPVD--LFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYTpNKKSRIYSMTLSLSAFF 1392
Cdd:cd05500    21 DARPFLVPVDpvKLNIPHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLTFN-GPEHPVSQMGKRLQAAF 99


                  ....
gi 688554583 1393 ENQI 1396
Cdd:cd05500   100 EKHL 103
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 1143-1229 2.13e-17

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 78.51  E-value: 2.13e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  1143 CERVItaiDQLLTLDVAKAFSNPVNLREYPLYCTVVAYLTDLSTIRTRLVHRFYRRISALMWEVRYIEHNARTFNEPQSP 1222
Cdd:pfam00439    1 CLEIL---DKLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTYNGPGSV 77


                   ....*..
gi 688554583  1223 IVTAAKT 1229
Cdd:pfam00439   78 IYKAAEK 84
Bromodomain cd04369
Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear ...
 1141-1238 5.78e-17

Bromodomain. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.


Pssm-ID: 99922 [Multi-domain]  Cd Length: 99  Bit Score: 77.80  E-value: 5.78e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1141 EECERVITAIDQLLTlDVAKAFSNPVNLREYPLYCTVVAYLTDLSTIRTRLVHRFYRRISALMWEVRYIEHNARTFNEPQ 1220
Cdd:cd04369     3 KKLRSLLDALKKLKR-DLSEPFLEPVDPKEAPDYYEVIKNPMDLSTIKKKLKNGEYKSLEEFEADVRLIFSNAKTYNGPG 81

                          90
                  ....*....|....*...
gi 688554583 1221 SPIVTAAKTVSDVLLRFI 1238
Cdd:cd04369    82 SPIYKDAKKLEKLFEKLL 99
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 1303-1393 2.46e-16

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 75.87  E-value: 2.46e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1303 CKDLVRRMIVSSDSEPFRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYTPNkKSRIY 1382
Cdd:cd05503     5 CETILDEMEAHEDAWPFLEPVNTKLVPGYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFNED-DSEVG 83

                          90
                  ....*....|.
gi 688554583 1383 SMTLSLSAFFE 1393
Cdd:cd05503    84 RAGHNMRKFFE 94
Bromodomain pfam00439
Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin ...
 1303-1382 1.71e-15

Bromodomain; Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 425683 [Multi-domain]  Cd Length: 84  Bit Score: 73.12  E-value: 1.71e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  1303 CKDLVRRMIVSSDSEPFRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYtpNKK-SRI 1381
Cdd:pfam00439    1 CLEILDKLMEHPIAAPFLEPVDPDEYPDYYSVIKKPMDLSTIKKKLENGEYKSLAEFLADVKLIFSNARTY--NGPgSVI 78


                   .
gi 688554583  1382 Y 1382
Cdd:pfam00439   79 Y 79
Bromo_tif1_like cd05502
Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of ...
 1301-1395 2.37e-15

Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or corepressors to modulate transcription. Vertebrate Tif1-gamma, also labeled E3 ubiquitin-protein ligase TRIM33, plays a role in the control of hematopoiesis. Its homologue in Xenopus laevis, Ectodermin, has been shown to function in germ-layer specification and control of cell growth during embryogenesis. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99934 [Multi-domain]  Cd Length: 109  Bit Score: 73.48  E-value: 2.37e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1301 KQCKDLVRRMIVSSDSEPFRQPVDLfTYPDYRDIIDTPMDLGTVSETLTGGN---YENPIEFAKDVRLIFSNskAYTPNK 1377
Cdd:cd05502     7 RKCERLLLELYCHELSLPFHEPVSP-SVPNYYKIIKTPMDLSLIRKKLQPKSpqhYSSPEEFVADVRLMFKN--CYKFNE 83

                          90
                  ....*....|....*....
gi 688554583 1378 -KSRIYSMTLSLSAFFENQ 1395
Cdd:cd05502    84 eDSEVAQAGKELELFFEEQ 102
Bromo_Acf1_like cd05504
Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was ...
 1303-1395 4.63e-15

Bromodomain; Acf1_like or BAZ1A_like subfamily. Bromo adjacent to zinc finger 1A (BAZ1A) was identified as a novel human bromodomain gene by cDNA library screening. The Drosophila homologue, Acf1, is part of the CHRAC (chromatin accessibility complex) and regulates ISWI-induced nucleosome remodeling. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99936  Cd Length: 115  Bit Score: 72.81  E-value: 4.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1303 CKDLVRRMIVSSDSEPFRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYTPnKKSRIY 1382
Cdd:cd05504    17 LEQLLVEIVKHKDSWPFLRPVSKIEVPDYYDIIKKPMDLGTIKEKLNMGEYKLAEEFLSDIQLVFSNCFLYNP-EHTSVY 95

                          90
                  ....*....|...
gi 688554583 1383 SMTLSLSAFFENQ 1395
Cdd:cd05504    96 KAGTRLQRFFIKR 108
Bromo_WSTF_like cd05505
Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The ...
 1301-1384 3.34e-14

Bromodomain; Williams syndrome transcription factor-like subfamily (WSTF-like). The Williams-Beuren syndrome deletion transcript 9 is a putative transcriptional regulator. WSTF was found to play a role in vitamin D-mediated transcription as part of two chromatin remodeling complexes, WINAC and WICH. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99937  Cd Length: 97  Bit Score: 69.87  E-value: 3.34e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1301 KQCKDLVRRMIVSSDSEPFRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYTPNKKSR 1380
Cdd:cd05505     3 QKCEEILSKILKYRFSWPFREPVTADEAEDYKKVITNPMDLQTMQTKCSCGSYSSVQEFLDDMKLVFSNAEKYYENGSYV 82


                  ....
gi 688554583 1381 IYSM 1384
Cdd:cd05505    83 LSCM 86
Bromo_AAA cd05528
Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long ...
 1304-1388 1.36e-13

Bromodomain; sub-family co-occurring with AAA domains. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine. The structure(2DKW) in this alignment is an uncharacterized protein predicted from analysis of cDNA clones from human fetal liver


Pssm-ID: 99957  Cd Length: 112  Bit Score: 68.54  E-value: 1.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1304 KDLVRRMIVSSDSEPFRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYTPNKKS---R 1380
Cdd:cd05528     9 RDVLKRLASDKRFNAFTKPVDEEEVPDYYEIIKQPMDLQTILQKLDTHQYLTAKDFLKDIDLIVTNALEYNPDRDPadkL 88


                  ....*...
gi 688554583 1381 IYSMTLSL 1388
Cdd:cd05528    89 IRSRACEL 96
BROMO smart00297
bromo domain;
1150-1240 2.32e-13

bromo domain;


Pssm-ID: 197636 [Multi-domain]  Cd Length: 107  Bit Score: 67.69  E-value: 2.32e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583   1150 IDQLLTLDVAKAFSNPVNLREYPLYCTVVAYLTDLSTIRTRLVHRFYRRISALMWEVRYIEHNARTFNEPQSPIVTAAKT 1229
Cdd:smart00297   16 LDKLDSHPLSWPFLKPVSRKEAPDYYDIIKKPMDLKTIKKKLENGKYSSVEEFVADFNLMFSNARTYNGPDSEVYKDAKK 95

                            90
                    ....*....|.
gi 688554583   1230 VSDVLLRFIRD 1240
Cdd:smart00297   96 LEKFFEKKLRE 106
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 1316-1393 3.81e-13

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 66.92  E-value: 3.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1316 SEPFRQPVD--LFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYTPnKKSRIYSMTLSLSAFFE 1393
Cdd:cd05499    21 NWPFLDPVDpvALNIPNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTFNP-EGTDVYMMGHQLEEVFN 99
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 1305-1385 2.46e-12

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 64.98  E-value: 2.46e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1305 DLVRRMIVSSDSEPFRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYtpNKKSRIYSM 1384
Cdd:cd05511     7 EIVNELKNLPDSWPFHTPVNKKKVPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLY--NGPDSVYTK 84


                  .
gi 688554583 1385 T 1385
Cdd:cd05511    85 K 85
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 1318-1396 1.14e-11

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 63.21  E-value: 1.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1318 PFRQPVDL--FTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNskAYTPNKKSR-IYSMTLSLSAFFEN 1394
Cdd:cd05497    25 PFQQPVDAvkLNLPDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTN--CYIYNKPGDdVVLMAQTLEKLFLQ 102


                  ..
gi 688554583 1395 QI 1396
Cdd:cd05497   103 KL 104
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 1313-1373 1.53e-11

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 62.84  E-value: 1.53e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 688554583 1313 SSDSEPFRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAY 1373
Cdd:cd05510    23 TEHSTPFLTKVSKREAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLY 83
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 1319-1382 2.24e-10

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 58.95  E-value: 2.24e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 688554583 1319 FRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYtpNKKSRIY 1382
Cdd:cd05512    22 FSEPVDLSEVPDYLDHIKQPMDFSTMRKKLESQRYRTLEDFEADFNLIINNCLAY--NAKDTIF 83
Bromo_gcn5_like cd05509
Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates ...
 1162-1241 2.22e-09

Bromodomain; Gcn5_like subfamily. Gcn5p is a histone acetyltransferase (HAT) which mediates acetylation of histones at lysine residues; such acetylation is generally correlated with the activation of transcription. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99941 [Multi-domain]  Cd Length: 101  Bit Score: 56.41  E-value: 2.22e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1162 FSNPVNLREYPLYCTVVAYLTDLSTIRTRLVHRFYRRISALMWEVRYIEHNARTFNEPQSPIVTAAKTVSDVLLRFIRDQ 1241
Cdd:cd05509    22 FLEPVDKEEAPDYYDVIKKPMDLSTMEEKLENGYYVTLEEFVADLKLIFDNCRLYNGPDTEYYKCANKLEKFFWKKLKEL 101
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 1013-1379 5.83e-09

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 60.20  E-value: 5.83e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1013 NESFSLKYHDMPDVIDFLVLqqfYNEAKERNwqpgqrfrSIIDDAWWFGSLECQEPFESEYPDSLFQCYIV--RWDNGER 1090
Cdd:COG5076    46 KNLFQKQLKRMPKEYITSIV---DDREPGSM--------ANVNDDLENVGGITYSPFEKNRPESLRFDEIVflAIESVTP 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1091 EKMSpwdiepipeEAPLPEEDGDSVPV-TEDELQALLYspqegewglhtrDEECERVITAIDQLLTLDVAK---AFSNPV 1166
Cdd:COG5076   115 ESGL---------GSLLMAHLKTSVKKrKTPKIEDELL------------YADNKAIAKFKKQLFLRDGRFlssIFLGLP 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1167 NLREYPLYCTVVAYLTDLSTIRTRLVHRFYR------RISALMWEvryiehNARTFNEPQSPIVTAAKTVSDVLLRFIRD 1240
Cdd:COG5076   174 SKREYPDYYEIIKSPMDLLTIQKKLKNGRYKsfeefvSDLNLMFD------NCKLYNGPDSSVYVDAKELEKYFLKLIEE 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1241 QnCTDILDLYnkmksefsseedeeetvdvdsdtpgtstgQRRSNSTPQKRGVVLdINAwhkqckdlvrrMIVSSDSEPFR 1320
Cdd:COG5076   248 I-PEEMLELS-----------------------------IKPGREEREERESVL-ITN-----------SQAHVGAWPFL 285

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 688554583 1321 QPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSN----SKAYTPNKKS 1379
Cdd:COG5076   286 RPVSDEEVPDYYKDIRDPMDLSTKELKLRNNYYRPEETFVRDAKLFFDNcvmyNGEVTDYYKN 348
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 1328-1388 6.19e-08

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 52.31  E-value: 6.19e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 688554583 1328 YPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYtpNK-KSRIYSMTLSL 1388
Cdd:cd05515    36 YPDYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKY--NEpDSQIYKDALTL 95
Bromo_Rsc1_2_I cd05521
Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are ...
 1327-1398 9.44e-08

Bromodomain, repeat I in Rsc1/2_like subfamily, specific to fungi. Rsc1 and Rsc2 are components of the RSC complex (remodeling the structure of chromatin), are essential for transcriptional control, and have a specific domain architecture including two bromodomains. The RSC complex has also been linked to homologous recombination and nonhomologous end-joining repair of DNA double strand breaks. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99952  Cd Length: 106  Bit Score: 51.94  E-value: 9.44e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 688554583 1327 TYPDYRDIIDTPMDLGTVSETLTggNYENPIEFAKDVRLIFSNSKAYTpNKKSRIYSMTLSLSAFFENQIIP 1398
Cdd:cd05521    36 DYPDYYKIIKNPLSLNTVKKRLP--HYTNAQEFVNDLAQIPWNARLYN-TKGSVIYKYALILEKYINDVIIP 104
Bromo_polybromo_IV cd05518
Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which ...
 1320-1382 1.11e-07

Bromodomain, polybromo repeat IV. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99949 [Multi-domain]  Cd Length: 103  Bit Score: 51.68  E-value: 1.11e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1320 RQPVDLFT-------YPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYTpNKKSRIY 1382
Cdd:cd05518    21 RRLCDLFMekpskkdYPDYYKIILEPIDLKTIEHNIRNDKYATEEELMDDFKLMFRNARHYN-EEGSQVY 89
Bromo_BAZ2A_B_like cd05503
Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B ...
 1148-1231 1.31e-07

Bromodomain, BAZ2A/BAZ2B_like subfamily. Bromo adjacent to zinc finger 2A (BAZ2A) and 2B (BAZ2B) were identified as a novel human bromodomain gene by cDNA library screening. BAZ2A is also known as Tip5 (Transcription termination factor I-interacting protein 5) and hWALp3. The proteins may play roles in transcriptional regulation. Human Tip5 is part of a complex termed NoRC (nucleolar remodeling complex), which induces nucleosome sliding and may play a role in the regulation of the rDNA locus. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99935  Cd Length: 97  Bit Score: 51.22  E-value: 1.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1148 TAIDQLLTLDVAKAFSNPVNLREYPLYCTVVAYLTDLSTIRTRLVHRFYRRISALMWEVRYIEHNARTFNEPQSPIVTAA 1227
Cdd:cd05503     7 TILDEMEAHEDAWPFLEPVNTKLVPGYRKIIKKPMDFSTIREKLESGQYKTLEEFAEDVRLVFDNCETFNEDDSEVGRAG 86


                  ....
gi 688554583 1228 KTVS 1231
Cdd:cd05503    87 HNMR 90
Bromo_polybromo_V cd05515
Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which ...
 1170-1240 2.51e-07

Bromodomain, polybromo repeat V. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99946  Cd Length: 105  Bit Score: 50.38  E-value: 2.51e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 688554583 1170 EYPLYCTVVAYLTDLSTIRTRLVHRFYRRISALMWEVRYIEHNARTFNEPQSPIVTAAKTVSDVLLRFIRD 1240
Cdd:cd05515    35 EYPDYYDVIKKPIDMEKIRSKIEGNQYQSLDDMVSDFVLMFDNACKYNEPDSQIYKDALTLQKVLLETKRE 105
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 1307-1373 4.46e-07

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 49.69  E-value: 4.46e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 688554583 1307 VRRMIVSSdSEPFRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAY 1373
Cdd:cd05508    12 LERMKQPG-AEPFLKPVDLEQFPDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAIIY 77
COG5076 COG5076
Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin ...
 1315-1414 4.60e-07

Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription];


Pssm-ID: 227408 [Multi-domain]  Cd Length: 371  Bit Score: 54.04  E-value: 4.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1315 DSEPFRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYtpN-KKSRIYSMTLSLSAFFE 1393
Cdd:COG5076   165 LSSIFLGLPSKREYPDYYEIIKSPMDLLTIQKKLKNGRYKSFEEFVSDLNLMFDNCKLY--NgPDSSVYVDAKELEKYFL 242

                          90       100
                  ....*....|....*....|.
gi 688554583 1394 NQIIPIISDYKSAVQNQRRSQ 1414
Cdd:COG5076   243 KLIEEIPEEMLELSIKPGREE 263
Bromo_BDF1_2_I cd05500
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast ...
 1149-1236 7.64e-07

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat I. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99932  Cd Length: 103  Bit Score: 49.23  E-value: 7.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1149 AIDQLLTLDVAKAFSNPV-----NLreyPLYCTVVAYLTDLSTIRTRLVHRFYRRISALMWEVRYIEHNARTFNEPQSPI 1223
Cdd:cd05500    12 SIRSLKRLKDARPFLVPVdpvklNI---PHYPTIIKKPMDLGTIERKLKSNVYTSVEEFTADFNLMVDNCLTFNGPEHPV 88

                          90
                  ....*....|...
gi 688554583 1224 VTAAKTVSDVLLR 1236
Cdd:cd05500    89 SQMGKRLQAAFEK 101
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 455-495 7.66e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 7.66e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 688554583    455 NGQLLHVLSGHDDEVFVLEAHPfDSRILLSAGHDGNIYVWD 495
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 254-296 7.88e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 7.88e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 688554583    254 TCAPVAVLQGHTASITSIQFSPsalgSSRFLATTGADGMVCFW 296
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP----DGKYLASGSDDGTIKLW 39
Bromo_RACK7 cd05508
Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) ...
 1159-1230 9.44e-07

Bromodomain, RACK7_like subfamily. RACK7 (also called human protein kinase C-binding protein) was identified as a potential tumor suppressor genes, it shares domain architecture with BS69/ZMYND11; both have been implicated in the regulation of cellular proliferation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99940  Cd Length: 99  Bit Score: 48.92  E-value: 9.44e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 688554583 1159 AKAFSNPVNLREYPLYCTVVAYLTDLSTIRTRLVHRFYRRISALMWEVRYIEHNARTFNEPQSPIVTAAKTV 1230
Cdd:cd05508    20 AEPFLKPVDLEQFPDYAQYVFKPMDLSTLEKNVRKKAYGSTDAFLADAKWILHNAIIYNGGDHKLTQAAKAI 91
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 171-208 1.37e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 1.37e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 688554583    171 MKMHRRILGHLSSVYCVAFDRTGRRIFTGSDDCLVKIW 208
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
175-208 2.09e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 2.09e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 688554583   175 RRILGHLSSVYCVAFDRTGRRIFTGSDDCLVKIW 208
Cdd:pfam00400    5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
Bromo_brd8_like cd05507
Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with ...
 1306-1373 2.79e-06

Bromodomain, brd8_like subgroup. In mammals, brd8 (bromodomain containing 8) interacts with the thyroid hormone receptor in a ligand-dependent fashion and enhances thyroid hormone-dependent activation from thyroid response elements. Brd8 is thought to be a nuclear receptor coactivator. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99939  Cd Length: 104  Bit Score: 47.74  E-value: 2.79e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 688554583 1306 LVRRMIVSSD-SEPFRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAY 1373
Cdd:cd05507    10 LVYRTLASHRyASVFLKPVTEDIAPGYHSVVYRPMDLSTIKKNIENGTIRSTAEFQRDVLLMFQNAIMY 78
Bromo_brd1_like cd05512
Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein ...
 1150-1202 2.99e-06

Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99944  Cd Length: 98  Bit Score: 47.39  E-value: 2.99e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 688554583 1150 IDQLLTLDVAKAFSNPVNLREYPLYCTVVAYLTDLSTIRTRLVHRFYRRISAL 1202
Cdd:cd05512    10 LDQLQEKDTAEIFSEPVDLSEVPDYLDHIKQPMDFSTMRKKLESQRYRTLEDF 62
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 182-392 3.52e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.01  E-value: 3.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  182 SSVYC-VAFDRTGRRIFTGSDDCLVKIWATD----NGRLL----ATLRGHAaEISDMTVN-FENTLLASASCDKIVRVWC 251
Cdd:PLN00181  483 SNLVCaIGFDRDGEFFATAGVNKKIKIFECEsiikDGRDIhypvVELASRS-KLSGICWNsYIKSQVASSNFEGVVQVWD 561

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  252 LRTCAPVAVLQGHTASITSIQFSPSalgSSRFLATTGADGMVCFWQWNS-FSMKFVdkpvkfmersRPGVQISCSSF-SS 329
Cdd:PLN00181  562 VARSQLVTEMKEHEKRVWSIDYSSA---DPTLLASGSDDGSVKLWSINQgVSIGTI----------KTKANICCVQFpSE 628

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 688554583  330 GGLFLATGGTDHmiRVYYLGTEMP-VKFSDLDSHTDKVVAIQFcnnTDSLRFVSGSRDGTARIW 392
Cdd:PLN00181  629 SGRSLAFGSADH--KVYYYDLRNPkLPLCTMIGHSKTVSYVRF---VDSSTLVSSSTDNTLKLW 687
Bromo_polybromo_II cd05517
Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which ...
 1328-1383 4.20e-06

Bromodomain, polybromo repeat II. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99948  Cd Length: 103  Bit Score: 47.05  E-value: 4.20e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 688554583 1328 YPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYtPNKKSRIYS 1383
Cdd:cd05517    36 YPDYYAVIKEPIDLKTIAQRIQSGYYKSIEDMEKDLDLMVKNAKTF-NEPGSQVYK 90
Bromo_polybromo_III cd05520
Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which ...
 1316-1382 4.54e-06

Bromodomain, polybromo repeat III. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99951  Cd Length: 103  Bit Score: 46.95  E-value: 4.54e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 688554583 1316 SEPF-RQPVDLFtYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYTPnKKSRIY 1382
Cdd:cd05520    24 AEPFlKLPSKRK-YPDYYQEIKNPISLQQIRTKLKNGEYETLEELEADLNLMFENAKRYNV-PNSRIY 89
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 212-250 4.94e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 4.94e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 688554583    212 NGRLLATLRGHAAEISDMTVNFENTLLASASCDKIVRVW 250
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
Bromo_SNF2L2 cd05516
Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI ...
 1301-1395 6.12e-06

Bromodomain, SNF2L2-like subfamily, specific to animals. SNF2L2 (SNF2-alpha) or SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 is a global transcriptional activator, which cooperates with nuclear hormone receptors to boost transcriptional activation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99947  Cd Length: 107  Bit Score: 46.65  E-value: 6.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1301 KQCKDLVRRMIVSSD------SEPFRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYT 1374
Cdd:cd05516     4 KKMNKIVDVVIKYKDsdgrqlAEVFIQLPSRKELPEYYELIRKPVDFKKIKERIRNHKYRSLEDLEKDVMLLCQNAQTFN 83

                          90       100
                  ....*....|....*....|.
gi 688554583 1375 pNKKSRIYSMTLSLSAFFENQ 1395
Cdd:cd05516    84 -LEGSLIYEDSIVLQSVFKSA 103
WD40 pfam00400
WD domain, G-beta repeat;
456-495 8.67e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 8.67e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 688554583   456 GQLLHVLSGHDDEVFVLEAHPfDSRILLSAGHDGNIYVWD 495
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
213-250 9.66e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 9.66e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 688554583   213 GRLLATLRGHAAEISDMTVNFENTLLASASCDKIVRVW 250
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
257-296 1.20e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 1.20e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 688554583   257 PVAVLQGHTASITSIQFSPsalgSSRFLATTGADGMVCFW 296
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSP----DGKLLASGSDDGTVKVW 38
Bromo_SP100C_like cd05501
Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major ...
 1309-1393 4.23e-05

Bromodomain, SP100C_like subfamily. The SP100C protein is a splice variant of SP100, a major component of PML-SP100 nuclear bodies (NBs), which are poorly understood. It is covalently modified by SUMO-1 and may play a role in processes at the chromatin level. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99933  Cd Length: 102  Bit Score: 44.34  E-value: 4.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1309 RMIVSSDSEP-FRQPvDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYtpNKKSRIYSMTLS 1387
Cdd:cd05501    11 LLKVYCMSKSgFFIS-KPYYIRDYCQGIKEPMWLNKVKERLNERVYHTVEGFVRDMRLIFHNHKLF--YKDDDFGQVGIT 87


                  ....*.
gi 688554583 1388 LSAFFE 1393
Cdd:cd05501    88 LEKKFE 93
Bromo_Brdt_II_like cd05498
Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET ...
 1162-1233 5.81e-05

Bromodomain, Brdt_like subfamily, repeat II. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99930  Cd Length: 102  Bit Score: 43.81  E-value: 5.81e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 688554583 1162 FSNPVN--LREYPLYCTVVAYLTDLSTIRTRLVHRFYRRISALMWEVRYIEHNARTFNEPQSPIVTAAKTVSDV 1233
Cdd:cd05498    24 FYKPVDpeALGLHDYHDIIKHPMDLSTIKKKLDNREYADAQEFAADVRLMFSNCYKYNPPDHPVHAMARKLQDV 97
Bromo_WDR9_I_like cd05529
Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome ...
 1314-1402 1.22e-04

Bromodomain; WDR9 repeat I_like subfamily. WDR9 is a human gene located in the Down Syndrome critical region-2 of chromosome 21. It encodes for a nuclear protein containing WD40 repeats and two bromodomains, which may function as a transcriptional regulator involved in chromatin remodeling and play a role in embryonic development. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99958  Cd Length: 128  Bit Score: 43.48  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1314 SDSEPFRQPVDLF-TYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNskAYTPNKKSriySMTLSLSAFF 1392
Cdd:cd05529    43 EIAEYFEYPVDLRaWYPDYWNRVPVPMDLETIRSRLENRYYRSLEALRHDVRLILSN--AETFNEPN---SEIAKKAKRL 117

                          90
                  ....*....|
gi 688554583 1393 ENQIIPIISD 1402
Cdd:cd05529   118 SDWLLRILSS 127
Bromo_BDF1_2_II cd05499
Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast ...
 1143-1233 2.03e-04

Bromodomain. BDF1/BDF2 like subfamily, restricted to fungi, repeat II. BDF1 and BDF2 are yeast transcription factors involved in the expression of a wide range of genes, including snRNAs; they are required for sporulation and DNA repair and protect histone H4 from deacetylation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99931  Cd Length: 102  Bit Score: 42.27  E-value: 2.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1143 CERVITAIDQLLTLDVAKAFSNPV-----NLreyPLYCTVVAYLTDLSTIRTRLVHRFYRRISALMWEVRYIEHNARTFN 1217
Cdd:cd05499     5 CEEVLKELMKPKHSAYNWPFLDPVdpvalNI---PNYFSIIKKPMDLGTISKKLQNGQYQSAKEFERDVRLIFKNCYTFN 81

                          90
                  ....*....|....*.
gi 688554583 1218 EPQSPIVTAAKTVSDV 1233
Cdd:cd05499    82 PEGTDVYMMGHQLEEV 97
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 359-393 2.37e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 2.37e-04
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 688554583    359 LDSHTDKVVAIQFCNntDSLRFVSGSRDGTARIWH 393
Cdd:smart00320    8 LKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLWD 40
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 1301-1373 3.07e-04

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 41.56  E-value: 3.07e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 688554583 1301 KQCKDLVRRMIVSSD------SEPFRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAY 1373
Cdd:cd05519     3 AAMLEIYDAVLNCEDetgrklSELFLEKPSKKLYPDYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTY 81
Bromo_SPT7_like cd05510
Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the ...
 1141-1240 4.46e-04

Bromodomain; SPT7_like subfamily. SPT7 is a yeast protein that functions as a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA, and SLIK. SAGA is involved in the RNA polymerase II-dependent transcriptional regulation of about 10% of all yeast genes. The SPT7 bromodomain has been shown to weakly interact with acetylated histone H3, but not H4. The human representative of this subfamily is cat eye syndrome critical region protein 2 (CECR2). Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99942 [Multi-domain]  Cd Length: 112  Bit Score: 41.66  E-value: 4.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1141 EECERVITaidQLLTL-DVAKAFSNPVNLREYPLYCTVVAYLTDLSTIRTRLVHRFYRRISALMWEVRYIEHNARTFN-E 1218
Cdd:cd05510    10 ESLDKVLN---ELKTYtEHSTPFLTKVSKREAPDYYDIIKKPMDLGTMLKKLKNLQYKSKAEFVDDLNLIWKNCLLYNsD 86

                          90       100
                  ....*....|....*....|....*
gi 688554583 1219 PQSPIVTAA---KTVSDVLLRFIRD 1240
Cdd:cd05510    87 PSHPLRRHAnfmKKKAEHLLKLIPD 111
Bromo_polybromo_I cd05524
Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which ...
 1329-1373 4.77e-04

Bromodomain, polybromo repeat I. Polybromo is a nuclear protein of unknown function, which contains 6 bromodomains. The human ortholog BAF180 is part of a SWI/SNF chromatin-remodeling complex, and it may carry out the functions of Yeast Rsc-1 and Rsc-2. It was shown that polybromo bromodomains bind to histone H3 at specific acetyl-lysine positions. Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine, but not all the bromodomains in polybromo may bind to acetyl-lysine.


Pssm-ID: 99954 [Multi-domain]  Cd Length: 113  Bit Score: 41.55  E-value: 4.77e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 688554583 1329 PDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAY 1373
Cdd:cd05524    39 PEYYEVVSNPIDLLKIQQKLKTEEYDDVDDLTADFELLINNAKAY 83
Bromo_Brdt_I_like cd05497
Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET ...
 1162-1235 9.07e-04

Bromodomain, Brdt_like subfamily, repeat I. Human Brdt is a testis-specific member of the BET subfamily of bromodomain proteins; the first bromodomain in Brdt has been shown to be essential for male germ cell differentiation. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99929  Cd Length: 107  Bit Score: 40.48  E-value: 9.07e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 688554583 1162 FSNPV-----NLreyPLYCTVVAYLTDLSTIRTRLVHRFYRRISALMWEVRYIEHNARTFNEPQSPIVTAAKTVSDVLL 1235
Cdd:cd05497    26 FQQPVdavklNL---PDYHKIIKTPMDLGTIKKRLENNYYWSASECIQDFNTMFTNCYIYNKPGDDVVLMAQTLEKLFL 101
Bromo_brd7_like cd05513
Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown ...
 1319-1382 1.18e-03

Bromodomain, brd7_like subgroup. The BRD7 gene encodes a nuclear protein that has been shown to inhibit cell growth and the progression of the cell cycle by regulating cell-cycle genes at the transcriptional level. BRD7 has been identified as a gene involved in nasopharyngeal carcinoma. The protein interacts with acetylated histone H3 via its bromodomain. Bromodomains are 110 amino acid long domains that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99945  Cd Length: 98  Bit Score: 40.09  E-value: 1.18e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 688554583 1319 FRQPVDLFTYPDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAYtpNKKSRIY 1382
Cdd:cd05513    22 FAFPVTDFIAPGYSSIIKHPMDFSTMKEKIKNNDYQSIEEFKDDFKLMCENAMKY--NKPDTIY 83
Bromo_ASH1 cd05525
Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the ...
 1329-1373 1.45e-03

Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in histones H3 and H4. Mammalian ASH1 has been shown to methylate histone H3. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99955 [Multi-domain]  Cd Length: 106  Bit Score: 40.07  E-value: 1.45e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 688554583 1329 PDYRDIIDTPMDLGTVSETLTGGNYENPIEFAKDVRLIFSNSKAY 1373
Cdd:cd05525    39 PDYYERITDPVDLSTIEKQILTGYYKTPEAFDSDMLKVFRNAEKY 83
Bromo_TFIID cd05511
Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, ...
 1161-1230 2.16e-03

Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to acetylated histone H4. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99943 [Multi-domain]  Cd Length: 112  Bit Score: 39.55  E-value: 2.16e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583 1161 AFSNPVNLREYPLYCTVVAYLTDLSTIRTRLVHRFYRRISALMWEVRYIEHNARTFNEPQSPIVTAAKTV 1230
Cdd:cd05511    20 PFHTPVNKKKVPDYYKIIKRPMDLQTIRKKISKHKYQSREEFLEDIELIVDNSVLYNGPDSVYTKKAKEM 89
Bromo_SNF2 cd05519
Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in ...
 1169-1235 3.85e-03

Bromodomain, SNF2-like subfamily, specific to fungi. SNF2 is a yeast protein involved in transcriptional activation, it is the catalytic component of the SWI/SNF ATP-dependent chromatin remodeling complex. The protein is essential for the regulation of gene expression (both positive and negative) of a large number of genes. The SWI/SNF complex changes chromatin structure by altering DNA-histone contacts within the nucleosome, which results in a re-positioning of the nucleosome and facilitates or represses the binding of gene-specific transcription factors. Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine.


Pssm-ID: 99950  Cd Length: 103  Bit Score: 38.47  E-value: 3.85e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 688554583 1169 REYPLYCTVVAYLTDLSTIRTRLVHRFYRRISALMWEVRYIEHNARTFNEPQSPIVTAAKTVSDVLL 1235
Cdd:cd05519    34 KLYPDYYVIIKRPIALDQIKRRIEGRAYKSLEEFLEDFHLMFANARTYNQEGSIVYEDAVEMEKAFK 100
PTZ00421 PTZ00421
coronin; Provisional
 210-296 4.24e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.80  E-value: 4.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 688554583  210 TDNGRLLAT---LRGHAAEISDMTVN-FENTLLASASCDKIVRVWCL-------RTCAPVAVLQGHTASITSIQFSPSAL 278
Cdd:PTZ00421   59 TDYGKLASNppiLLGQEGPIIDVAFNpFDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAM 138

                          90
                  ....*....|....*...
gi 688554583  279 GssrFLATTGADGMVCFW 296
Cdd:PTZ00421  139 N---VLASAGADMVVNVW 153
WD40 pfam00400
WD domain, G-beta repeat;
359-392 5.70e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 5.70e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 688554583   359 LDSHTDKVVAIQFcnNTDSLRFVSGSRDGTARIW 392
Cdd:pfam00400    7 LEGHTGSVTSLAF--SPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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