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Conserved domains on  [gi|688553169|ref|XP_009299425|]
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cystatin 14b, tandem duplicate 1 isoform X1 [Danio rerio]

Protein Classification

cystatin family protein( domain architecture ID 430)

cystatin family protein may function as a cysteine protease inhibitor, such as Glycine max cystatin that inhibits papain and cathepsin B

CATH:  3.10.450.10
Gene Ontology:  GO:0004869|GO:0010466
SCOP:  4001013

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CY super family cl09238
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
7-78 1.73e-09

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


The actual alignment was detected with superfamily member pfam00031:

Pssm-ID: 447698  Cd Length: 92  Bit Score: 50.03  E-value: 1.73e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 688553169    7 GGQSEEKQATPEVQKICDEVKHQAEEKA-GKKFTAFTAILFTTQVVAGTNYFIKVNVGGDQFI-HLRVHKPLPH 78
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPL 74
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
7-78 1.73e-09

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 50.03  E-value: 1.73e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 688553169    7 GGQSEEKQATPEVQKICDEVKHQAEEKA-GKKFTAFTAILFTTQVVAGTNYFIKVNVGGDQFI-HLRVHKPLPH 78
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPL 74
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
6-63 2.69e-08

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 47.42  E-value: 2.69e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553169     6 VGGQSEEKQATPEVQKICDEVKHQAEEKAGKKF--TAFTAILFTTQVVAGTNYFIKVNVG 63
Cdd:smart00043   3 LGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYelRVIKVVSAKSQVVAGTNYYLKVEVG 62
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
17-63 6.82e-05

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 38.61  E-value: 6.82e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 688553169  17 PEVQKICDEVKHQAEEKAGKK-FTAFTAILFTTQVVAGTNYFIKVNVG 63
Cdd:cd00042   11 PEVQELADFAVAEYNKKSNDKyLEFFKVLSAKSQVVAGTNYYITVEAG 58
 
Name Accession Description Interval E-value
Cystatin pfam00031
Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. ...
7-78 1.73e-09

Cystatin domain; Very diverse family. Attempts to define separate sub-families failed. Typically, either the N-terminal or C-terminal end is very divergent. But splitting into two domains would make very short families. pfam00666 is related to this family but has not been included.


Pssm-ID: 425431  Cd Length: 92  Bit Score: 50.03  E-value: 1.73e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 688553169    7 GGQSEEKQATPEVQKICDEVKHQAEEKA-GKKFTAFTAILFTTQVVAGTNYFIKVNVGGDQFI-HLRVHKPLPH 78
Cdd:pfam00031   1 GGLSPIPDNSPELQEALDFALAEYNAKTdNYYFELVEVKRAKSQVVAGTNYFIKVEVGETDCSkSKKLLEDCPL 74
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
6-63 2.69e-08

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 47.42  E-value: 2.69e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 688553169     6 VGGQSEEKQATPEVQKICDEVKHQAEEKAGKKF--TAFTAILFTTQVVAGTNYFIKVNVG 63
Cdd:smart00043   3 LGGPSDVPPNDPEVQEAADFAVAEYNKKSNDKYelRVIKVVSAKSQVVAGTNYYLKVEVG 62
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
17-63 6.82e-05

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 38.61  E-value: 6.82e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 688553169  17 PEVQKICDEVKHQAEEKAGKK-FTAFTAILFTTQVVAGTNYFIKVNVG 63
Cdd:cd00042   11 PEVQELADFAVAEYNKKSNDKyLEFFKVLSAKSQVVAGTNYYITVEAG 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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