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Conserved domains on  [gi|688612483|ref|XP_009295336|]
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UBX domain-containing protein 10 isoform X1 [Danio rerio]

Protein Classification

ubiquitin family protein( domain architecture ID 13018795)

ubiquitin family protein belongs to an diverse class of protein modifier and gene expression regulatory proteins that participate in a number of cellular processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UBX_UBXN10 cd17076
Ubiquitin regulatory domain X (UBX) found in UBX domain protein 10 (UBXN10) and similar ...
 136-211 1.80e-35

Ubiquitin regulatory domain X (UBX) found in UBX domain protein 10 (UBXN10) and similar proteins; UBXN10, also termed UBX domain-containing protein 3 (UBXD3), belongs to the UBXD family of proteins that contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. UBXN10 functions as a cofactor of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. UBXN10 localizes to cilia in a p97-dependent manner, and both p97 and UBXN10 are required for ciliogenesis. Additionally, UBXN10 interacts with the intraflagellar transport B (IFT-B) and regulates anterograde transport into cilia.


:

Pssm-ID: 340596  Cd Length: 76  Bit Score: 120.04  E-value: 1.80e-35
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 688612483 136 SDLLLAIRTPCGQRFKRSFRPSDQLKGVLSAAEAEFGDRFDNCIIETMDVPRRTFSNLTMTLAQCGVLNKSVLCIS 211
Cdd:cd17076    1 PRILLAIRLPDGQRFQRFFRPSDTLQDVLAFAESQSGLDLSNCIIETNEVPRRVFSDLSKTIAECGIQDKTVLYIE 76
 
Name Accession Description Interval E-value
UBX_UBXN10 cd17076
Ubiquitin regulatory domain X (UBX) found in UBX domain protein 10 (UBXN10) and similar ...
 136-211 1.80e-35

Ubiquitin regulatory domain X (UBX) found in UBX domain protein 10 (UBXN10) and similar proteins; UBXN10, also termed UBX domain-containing protein 3 (UBXD3), belongs to the UBXD family of proteins that contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. UBXN10 functions as a cofactor of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. UBXN10 localizes to cilia in a p97-dependent manner, and both p97 and UBXN10 are required for ciliogenesis. Additionally, UBXN10 interacts with the intraflagellar transport B (IFT-B) and regulates anterograde transport into cilia.


Pssm-ID: 340596  Cd Length: 76  Bit Score: 120.04  E-value: 1.80e-35
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 688612483 136 SDLLLAIRTPCGQRFKRSFRPSDQLKGVLSAAEAEFGDRFDNCIIETMDVPRRTFSNLTMTLAQCGVLNKSVLCIS 211
Cdd:cd17076    1 PRILLAIRLPDGQRFQRFFRPSDTLQDVLAFAESQSGLDLSNCIIETNEVPRRVFSDLSKTIAECGIQDKTVLYIE 76
UBX smart00166
Domain present in ubiquitin-regulatory proteins; Present in FAF1 and Shp1p.
 139-208 2.68e-04

Domain present in ubiquitin-regulatory proteins; Present in FAF1 and Shp1p.


Pssm-ID: 197552 [Multi-domain]  Cd Length: 77  Bit Score: 38.44  E-value: 2.68e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 688612483   139 LLAIRTPCGQRFKRSFRPSDQLKGVLSAAEAEFGDRFDNCIIETMdVPRRTFSNLTM---TLAQCGVLNKSVL 208
Cdd:smart00166   3 RLQIRLPDGSRLVRRFPSSDTLRTVYEFVSAALGDGNDPFTLNSP-FPRRTFTKDDYskkLLELALLPSSTLV 74
 
Name Accession Description Interval E-value
UBX_UBXN10 cd17076
Ubiquitin regulatory domain X (UBX) found in UBX domain protein 10 (UBXN10) and similar ...
 136-211 1.80e-35

Ubiquitin regulatory domain X (UBX) found in UBX domain protein 10 (UBXN10) and similar proteins; UBXN10, also termed UBX domain-containing protein 3 (UBXD3), belongs to the UBXD family of proteins that contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. UBXN10 functions as a cofactor of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. UBXN10 localizes to cilia in a p97-dependent manner, and both p97 and UBXN10 are required for ciliogenesis. Additionally, UBXN10 interacts with the intraflagellar transport B (IFT-B) and regulates anterograde transport into cilia.


Pssm-ID: 340596  Cd Length: 76  Bit Score: 120.04  E-value: 1.80e-35
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 688612483 136 SDLLLAIRTPCGQRFKRSFRPSDQLKGVLSAAEAEFGDRFDNCIIETMDVPRRTFSNLTMTLAQCGVLNKSVLCIS 211
Cdd:cd17076    1 PRILLAIRLPDGQRFQRFFRPSDTLQDVLAFAESQSGLDLSNCIIETNEVPRRVFSDLSKTIAECGIQDKTVLYIE 76
UBX cd01767
Ubiquitin regulatory domain X (UBX) structurally similar to a beta-grasp ubiquitin-like fold; ...
 140-208 2.62e-06

Ubiquitin regulatory domain X (UBX) structurally similar to a beta-grasp ubiquitin-like fold; The UBXD family of proteins contains the ubiquitin regulatory domain X (UBX) with a beta-grasp ubiquitin-like fold, but without the C-terminal double glycine motif. UBX domain is typically located at the carboxyl terminus of proteins, and participates broadly in the regulation of protein degradation. Members in this family function as cofactors of p97 (also known as VCP or Cdc48), which is a homohexameric AAA ATPase (ATPase associated with a variety of activities) involved in a variety of functions ranging from cell-cycle regulation to membrane fusion and protein degradation. Based on domain composition, UBXD proteins can be divided into two main groups, with and without ubiquitin-associated (UBA) domain.


Pssm-ID: 340466 [Multi-domain]  Cd Length: 74  Bit Score: 43.79  E-value: 2.62e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 688612483 140 LAIRTPCGQRFKRSFRPSDQLKGVLSAAEAEFGDRFDNCIIETMDvPRRTFSNLTM--TLAQCGVLNKSVL 208
Cdd:cd01767    2 IQIRLPDGSRIQRRFSKSDTLQDLYDFVESNLGDSPSSFSLVTSF-PRRVLTDEDSdkTLEELGLTPNAVL 71
UBX smart00166
Domain present in ubiquitin-regulatory proteins; Present in FAF1 and Shp1p.
 139-208 2.68e-04

Domain present in ubiquitin-regulatory proteins; Present in FAF1 and Shp1p.


Pssm-ID: 197552 [Multi-domain]  Cd Length: 77  Bit Score: 38.44  E-value: 2.68e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 688612483   139 LLAIRTPCGQRFKRSFRPSDQLKGVLSAAEAEFGDRFDNCIIETMdVPRRTFSNLTM---TLAQCGVLNKSVL 208
Cdd:smart00166   3 RLQIRLPDGSRLVRRFPSSDTLRTVYEFVSAALGDGNDPFTLNSP-FPRRTFTKDDYskkLLELALLPSSTLV 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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