|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
40-479 |
1.65e-151 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 437.44 E-value: 1.65e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 40 AFILHLCNFSVYTQQMNLSIAITAMVNTTAASSHANASIERPTtdsqdfwnetlQESKAPVYDWTPEIQGILLSSLNYGS 119
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTDKDT-----------LPVEAPEFDWSEKTQGIILSSFFYGY 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 120 FLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAEAGVALLIVLRVIQGMSQVMVLTGQYSMWAKWAPPLERSQLI 199
Cdd:cd17318 70 ILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLT 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 200 TIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLLWFPLVyddpqnhpfistgekryimcslaqedcslgw 279
Cdd:cd17318 150 SIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 280 slpikamvksLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRNIL 359
Cdd:cd17318 199 ----------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGIL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 360 RLVTIRKLFTALGVLVSSGILVPLPWVSSSLSTTMAFLVLSSVFASLCDSGALINFLDIAPRYAGFLKGLLQVFSYLAGG 439
Cdd:cd17318 269 STTTVRKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGI 348
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 672081819 440 IAPTVAGFFISQD-SEFGWRNVFLLAAAIDVVGLLFYLIFG 479
Cdd:cd17318 349 ISPLIVGAIVKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
30-489 |
1.43e-135 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 399.50 E-value: 1.43e-135
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 30 KGCCSLRHGLAFILHLCNFSVYTQQMNLSIAITAMVNTTAASSHANASIERPTTDSQDfwnetlqeskaPVYDWTPEIQG 109
Cdd:TIGR00894 11 PYFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENELDNIKN-----------PNFKWSGALQG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 110 ILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAEAGVALLIVLRVIQGMSQVMVLTGQYSMWAKW 189
Cdd:TIGR00894 80 LILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 190 APPLERSQLITIAASGSMLGTFLVLIAGGLLCQA-LGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGEKRYIMC 268
Cdd:TIGR00894 160 APPKERSRLLGMSTSGFQLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 269 SLAQEDCSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGL 348
Cdd:TIGR00894 240 SLQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGY 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 349 LADFLLSRNILRLVTIRKLFTALGVLVSSGILVPLPWVSSSLSTTMAFLVLSSVFASLCDSGALINFLDIAPRYAGFLKG 428
Cdd:TIGR00894 320 LADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKG 399
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672081819 429 LLQVFSYLAGGIAPTVAGFFISQDSEFGWRNVFLLAAAIDVVGLLFYLIFGRAEVQDWAKE 489
Cdd:TIGR00894 400 ITGLPGFIGGLIASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKE 460
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
39-479 |
6.29e-102 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 310.94 E-value: 6.29e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 39 LAFILHLCNFSVYTQQMNLSIAITAMVNTTAASSHANASIERPTTDSQdfwNETLQESKAPVYDWTPEIQGILLSSLNYG 118
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNACPEHSSS---PSVEHNETGKKYDWDAETQGWILGSFFYG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 119 SFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAEAGVALLIVLRVIQGMSQVMVLTGQYSMWAKWAPPLERSQL 198
Cdd:cd17381 78 YIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 199 ITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLLWFPLVyddpqnhpfistgekryimcslaqedcslg 278
Cdd:cd17381 158 LTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV------------------------------ 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 279 wslpikamvksLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRNI 358
Cdd:cd17381 208 -----------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQN 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 359 LRLVTIRKLFTALGVLVSSGILVPLPWVSSSLSTTMAFLVLSSVFASLCDSGALINFLDIAPRYAGFLKGLLQVFSYLAG 438
Cdd:cd17381 277 FSTVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPG 356
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 672081819 439 GIAPTVAGFFISQDSEFGWRNVFLLAAAIDVVGLLFYLIFG 479
Cdd:cd17381 357 MVGPVIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
56-479 |
3.97e-73 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 236.08 E-value: 3.97e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 56 NLSIAITAMVNTTAASSHANASIERPTtdsqdfwnetlqeskapvYDWTPEIQGILLSSLNYGSFLAPIPTGYVAGVFGA 135
Cdd:cd17382 17 NLGVAIVRMVNNFTDAYGGKVIVHKAE------------------FNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 136 KYVVGLGLLVSSVLTLFIPLAAEAGVALLIVLRVIQGMSQVMVLTGQYSMWAKWAPPLERSQLITIAASGSMLGTFLVLI 215
Cdd:cd17382 79 NRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMP 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 216 AGGLLCQALGWPYIFYIFGGIGCacclLWFplvyddpqnhpfistgekryimcslaqedcsLGWslpikaMVKSLPLWAI 295
Cdd:cd17382 159 LSGILVQYVGWSSPFYVYGVFGI----IWY-------------------------------MFW------MLVSMPVYAI 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 296 VVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRNILRLVTIRKLFTALGVLV 375
Cdd:cd17382 198 IVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCGGFGM 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 376 SSGILVPLPWVSSSlSTTMAFLVLSSVFASLCDSGALINFLDIAPRYAGFLKGLLQVFSYLAGGIAPTVAGFFISQDSEF 455
Cdd:cd17382 278 EATFLLVVAFSHSP-TVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKHKTRE 356
|
410 420
....*....|....*....|....
gi 672081819 456 GWRNVFLLAAAIDVVGLLFYLIFG 479
Cdd:cd17382 357 EWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
101-479 |
8.62e-60 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 200.47 E-value: 8.62e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 101 YDWTPEIQGILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAEAGVALLIVLRVIQGMSQVMVLT 180
Cdd:cd17380 29 FGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 181 GQYSMWAKWAPPLERSQLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLLWFPLVyddpqnhpfist 260
Cdd:cd17380 109 SMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL------------ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 261 gekryimcslaqedcslgwslpikamvksLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLqANLRDSGILSALPFMFGC 340
Cdd:cd17380 177 -----------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMF 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 341 VCIILGGLLADFLLSRNIlRLVTIRKLFTALGVLVSSGILVPLPWVsSSLSTTMAFLVLSSVFASLCDSGALINFLDIAP 420
Cdd:cd17380 227 PSSNVAGWLADHLISRGW-TVTSVRKLMQSIGFLGPALFLLLLSHT-DSFSLALLCMSVALGLSAFSSSGVLVNHQDIAP 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 672081819 421 RYAGFLKGLLQVFSYLAGGIAPTVAGFFISQDSEfgWRNVFLLAAAIDVVGLLFYLIFG 479
Cdd:cd17380 305 NYAGIVFGISNTAGTIPGIVGVYLTGYILEATGS--WSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
101-480 |
1.46e-32 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 127.29 E-value: 1.46e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 101 YDWTPEIQGILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAeaGVALLIVLRVIQGMSQVMVLT 180
Cdd:COG2271 40 LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 181 GQYSMWAKWAPPLERSQLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGcaccLLWFPLvyddpqnhpfist 260
Cdd:COG2271 118 AALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPG----LLLALL------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 261 gekryimcslaqedcslgwslpikamvkslPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFGC 340
Cdd:COG2271 181 ------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGI 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 341 VCIILGGLLADFLLSRnilrlvtiRKLFTALGVLVSSGILVPLPWVsSSLSTTMAFLVLSSVFASLCDSGALINFLDIAP 420
Cdd:COG2271 231 VGSLLGGWLSDRLGRR--------RKLVLAIGLLLAALALLLLALL-PSPALAIALLFLAGFGLGGAFGLLWALAAELFP 301
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672081819 421 -RYAGFLKGLLQVFSYLAGGIAPTVAGFFISQdseFGWRNVFLLAAAIDVVGLLFYLIFGR 480
Cdd:COG2271 302 kKARGTASGLVNTFGFLGGALGPLLVGYLLDA---TGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
103-477 |
6.65e-29 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 116.90 E-value: 6.65e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 103 WTPEIQGILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAeaGVALLIVLRVIQGMSQVMVLTGQ 182
Cdd:cd17319 35 LSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFAT--SLTSLYVLRFLLGVAEAGFFPGA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 183 YSMWAKWAPPLERSQLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLLWFPLVYDdpqnhpfistge 262
Cdd:cd17319 113 IKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ------------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 263 kryimcslaqedcslgwslpikamvkslpLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFGCVC 342
Cdd:cd17319 181 -----------------------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIG 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 343 IILGGLLADFLLSRNilrlvtiRKLFTALGVLVSSGILVPLPwVSSSLSTTMAFLVLSSVFASLCDSGALINFLDIAPR- 421
Cdd:cd17319 232 MILGGRLSDRLLRGA-------RRLVIIIGLLLAAVGLLLAY-LTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGe 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 672081819 422 YAGFLKGLLQVFSYLAGGIAPTVAGFFIsqDSEFGWRNVFLLAAAIDVVGLLFYLI 477
Cdd:cd17319 304 AAATAGGLINSGGNLGGFVAPLLIGYLV--DATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
101-442 |
4.35e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 105.96 E-value: 4.35e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 101 YDWTPEIQGILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAeaGVALLIVLRVIQGMSQVMVLT 180
Cdd:pfam07690 27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRVLQGLGAGALFP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 181 GQYSMWAKWAPPLERSQLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLLWFpLVYDDPQNHPFIST 260
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL-LPRPPPESKRPKPA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 261 GEKRyimcslaqedcsLGWSLPIKAMVKSLPLWAIVVSyFCEYWLLFTIMAYTPTYIsSVLQANLRDSGILSALPFMFGC 340
Cdd:pfam07690 184 EEAR------------LSLIVAWKALLRDPVLWLLLAL-LLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 341 VCIILGGLLADFLLSRNILrlvtirkLFTALGVLVSSGILVPLPWVSSSLSTTMAFLVLSSVFASLCDSGALINFLDIAP 420
Cdd:pfam07690 250 IGRLLLGRLSDRLGRRRRL-------LLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPK 322
|
330 340
....*....|....*....|..
gi 672081819 421 RYAGFLKGLLQVFSYLAGGIAP 442
Cdd:pfam07690 323 EERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
100-476 |
1.53e-22 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 99.04 E-value: 1.53e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 100 VYDWTPEIQGILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAeaGVALLIVLRVIQGMSQVMVL 179
Cdd:cd06174 25 SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP--SFWLLLLGRFLLGLGSGLID 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 180 TGQYSMWAKWAPPLERSQLITIAASGSMLGTFLVLIAGGLLCQAL--GWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPF 257
Cdd:cd06174 103 PAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAALALLAAILLLLVVPDPPESARA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 258 ISTGEKryimcslaqedcSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFM 337
Cdd:cd06174 183 KNEEAS------------SKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 338 FGCVCIILGGLLADFLLSrnilrlvtiRKLFTALGVLVSSGILVPLPWVSSSLSTTMAFLVLSSVFASLCDSGALINFLD 417
Cdd:cd06174 251 AGALGSLLLGLLSDRLIG---------RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAEL 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 672081819 418 IAPRYAGFLKGLLQVFSYLAGGIAPTVAGFFISQDseFGWRNVFLLAAAIDVVGLLFYL 476
Cdd:cd06174 322 FPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAT--FGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
109-478 |
8.18e-21 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 93.79 E-value: 8.18e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 109 GILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAEagVALLIVLRVIQGMSQVMVLTGQYSMWAK 188
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS--YWQLLLARFLQGLASAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 189 WAPPLERSQLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPfistgekryimc 268
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPN------------ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 269 slAQEDCSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGL 348
Cdd:cd17325 180 --KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 349 LADfllsrnilrlvTIRKLFTALGVLVSSGILVPLPWVSSSLSTTMAFLVLSSVFASLCDSGALINFLDIAPRYA-GFLK 427
Cdd:cd17325 258 LSD-----------RIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGrGTAM 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 672081819 428 GLLQVFSYLAGGIAPTVAGFFISQdseFGWRNVFLLAAAIDVVGLLFYLIF 478
Cdd:cd17325 327 GLFNTAFSLGMVLGPLLGGFLYDA---FGFATPFLAAAALLLLAAVLFLLL 374
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
101-480 |
1.29e-19 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 90.71 E-value: 1.29e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 101 YDWTPEIQGILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAeaGVALLIVLRVIQGMSQVMVLT 180
Cdd:COG2223 35 FGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV--SYWLLLLLGLLLGIGGGGSFA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 181 GQYSMWAKWAPPLERSQLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFIST 260
Cdd:COG2223 113 VGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAK 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 261 GEKRyimcslaqedcslgwslPIKAMVKSLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFGC 340
Cdd:COG2223 193 ASLR-----------------DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 341 VCIILGGLLADFLLSRNILRLVTIrklFTALGVLVSSGILVPLPWVSSSLSTTMAFL--VLSSVFASLCDSgalinfldI 418
Cdd:COG2223 256 LGRPLGGWLSDRIGGRRVLLIVFA---LMALGLLLLALALGSLWLFLVLFLLLGLALggGNGAVFALVPDI--------F 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672081819 419 APRYAGFLKGLLQVFSYLAGGIAPTVAGFFIsqDSEFGWRNVFLLAAAIDVVGLLFYLIFGR 480
Cdd:COG2223 325 PTKNAGAVYGLVGAAGGLGGFLGPLLFGALL--DATGSYTAAFLVFAVLALVALVLTLLLYR 384
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
101-441 |
7.00e-18 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 85.03 E-value: 7.00e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 101 YDWTPEIQGILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAeaGVALLIVLRVIQGMSQVMVLT 180
Cdd:COG2814 40 LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP--SLWLLLAARFLQGLGAGALFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 181 GQYSMWAKWAPPLERSQLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLLWFPLVyddPQNHPFIST 260
Cdd:COG2814 118 AALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLL---PESRPAARA 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 261 GEKRyimcslaqedcslgwslPIKAMVKSLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFGC 340
Cdd:COG2814 195 RLRG-----------------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGV 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 341 VCIILGGLLADFLLSRNILrlvtirklftaLGVLVSSGILVPLPWVSSSLSTTMAFLVLSSVFASLCDSGALINFLDIAP 420
Cdd:COG2814 258 LGALLAGRLADRFGRRRLL-----------LIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326
|
330 340
....*....|....*....|..
gi 672081819 421 -RYAGFLKGLLQVFSYLAGGIA 441
Cdd:COG2814 327 pEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
109-476 |
1.83e-17 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 83.75 E-value: 1.83e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 109 GILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAeaGVALLIVLRVIQGMSQVMVLTGQYSMWAK 188
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAP--SFALLLLARALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 189 WAPPLERSQLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFistgekryimc 268
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPG----------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 269 slaqedcSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQAnlrDSGILSALPFMFGcVCIILGGL 348
Cdd:cd17324 184 -------SLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGF---SSSAIIGLLLLFG-VAGVVGSP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 349 LADFLLSRNilrlvTIRKLFTALGVLVSSGILVPLPWVSSSLSTTMAFLVlsSVFASLCDSGALINFLDIAPRYAGFLKG 428
Cdd:cd17324 253 LAGRLADRG-----GRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLW--GLGFFAAHSALQTRVLRLAPEARGLASS 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 672081819 429 LLQVFSYLAGGIAPTVAGFFISQdseFGWRNVFLLAAAIDVVGLLFYL 476
Cdd:cd17324 326 LYLAAYNLGGALGAALGGLVLDH---GGWAGVGWVGAALLLLALLLAL 370
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
109-461 |
1.21e-15 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 78.57 E-value: 1.21e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 109 GILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFipLAAEAGVALLIVLRVIQGMSQVMVLTGQYSMWAK 188
Cdd:TIGR00881 33 GLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLF--FGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTK 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 189 WAPPLERSQLITIAASGSML-GTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGEKR--- 264
Cdd:TIGR00881 111 WFSRSERGTWVSFWNCSHNVgGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPnee 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 265 YIMCSLAQEDCSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFGCVCII 344
Cdd:TIGR00881 191 PDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTL 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 345 LGGLLADFLLSRNilRLVTirKLFTALGVLVSSGILVPLPWVSSSLSTTMAFLVLSSVFASLCDSGALINflDIAP-RYA 423
Cdd:TIGR00881 271 LAGWLSDKLFNGR--RGPL--AVFFMALIIVSLLVYWLNPAANPLMDLICLFALGFLVYGPQMLIGVIAS--ELAPkKAA 344
|
330 340 350
....*....|....*....|....*....|....*...
gi 672081819 424 GFLKGLLQVFSYLAGGIAPTVAGFFISQdseFGWRNVF 461
Cdd:TIGR00881 345 GTAAGFVGFFAYLGGILAGLPLGYLADG---FGWAGAF 379
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
109-481 |
4.69e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 67.57 E-value: 4.69e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 109 GILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAaeAGVALLIVLRVIQGMSQVMVLTGQYSMwAK 188
Cdd:COG0738 46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALA--PSYPLLLLALFLLGLGLGLLDVAANPY-VA 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 189 WAPPLERSQLITIAASGSMLGTFLVLIAGGLLCQA---LGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGEKRy 265
Cdd:COG0738 123 ALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAA- 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 266 imcslaqedcslgwslPIKAMVKSLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALpFMFGcvcIIL 345
Cdd:COG0738 202 ----------------SLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSL-FWGG---MTI 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 346 GGLLADFLLSRnilrlVTIRKLFTALGVLVSSGILvpLPWVSSSLSTTMAFLVLSSVFASLCDSGALINFLDIAPRYAGF 425
Cdd:COG0738 262 GRFLGGFLLKR-----FGPVRLLRLSALLAAVGLL--LALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAA 334
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 672081819 426 LKGLLQVFSYLAGGIAPTVAGFFISQdseFGWRNVFLLAAAIDVVGLLFYLIFGRA 481
Cdd:COG0738 335 AVSAVLIMGIVGGAIGPPLIGFLADA---FGLRAAFLVPLVCYLLILLLALALKRK 387
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
127-478 |
1.48e-11 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 65.76 E-value: 1.48e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 127 GYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAEagVALLIVLRVIQGMSQVMVLTGQYSMWAKWAPPLERSQLITIAASGS 206
Cdd:cd17312 59 GFLSDRSNIRRFMSAGLLLSALANIFMGFSTS--LWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSH 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 207 MLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNhpfistgekryimcslaqedcslgwslpikam 286
Cdd:cd17312 137 NFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSPPY-------------------------------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 287 vkslpLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRNilRLVTIrk 366
Cdd:cd17312 185 -----VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGR--RAPIA-- 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 367 LFTALGVLVSSGILVPLPwVSSSLSTTMAFLVLSSVFASLCDSGALINfLDIAPRYA-GFLKGLLQVFSYLAGGIAPTVA 445
Cdd:cd17312 256 VIYMLLMTLSLALFWFFP-HNKLLSIVLLFLIGFFVGGPINLIGGAAA-QDIGRKEAaGTATGFVGLFGYLGASLAGLPL 333
|
330 340 350
....*....|....*....|....*....|...
gi 672081819 446 GFFISQdseFGWRNVFLLAAAIDVVGLLFYLIF 478
Cdd:cd17312 334 GYIIDH---YGWSTVFYFLISAALLSVLLLLSL 363
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
104-355 |
3.06e-10 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 61.37 E-value: 3.06e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 104 TPEIQGILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAeaGVALLIVLRVIQGMSQVMVLTGQY 183
Cdd:COG0477 47 SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAP--SPELLIAARALQGIGAGGLMPGAL 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 184 SMWAKWAPPLERSQLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGcaccLLWFPLVYDDPQNHPFISTGEK 263
Cdd:COG0477 125 ALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLG----LLALVLRLRLPESRGLLLALLA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 264 RYIMCSLAQEDCSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFGCVCI 343
Cdd:COG0477 201 LALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLL 280
|
250
....*....|..
gi 672081819 344 ILGGLLADFLLS 355
Cdd:COG0477 281 LLLLLLLLLLLA 292
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
121-485 |
3.49e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 61.81 E-value: 3.49e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 121 LAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFipLAAEAGVALLIVLRVIQGMSqVMVLTGQYSMWAKWAPPLERSQLIT 200
Cdd:COG2807 68 LFAPLAPRLARRFGLERTLLLALLLLAAGLLL--RSLAPSVALLLAGTALIGAG-IAVGNVLLPGLIKRWFPDRVGLMTG 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 201 IAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPfistgekryimcslaqedcSLGWS 280
Cdd:COG2807 145 LYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAA-------------------AAPAA 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 281 LPIKAMVKSLPLWAIVVSYFCEYWLLFTIMAYTPTYISSvLQANLRDSGILSALPFMFGCVCIILGGLLADfllsrnilR 360
Cdd:COG2807 206 ASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLAD--------R 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 361 LVTIRKLFTALGVLVSSGILVpLPWVSSSLstTMAFLVLSSVFASLCDSGALINFLDIA--PRYAGFLKGLLQVFSYLAG 438
Cdd:COG2807 277 LGDRRPLLLLLGLLGLAGLLG-LLLAPGSL--PWLWAVLLGLGQGGLFPLALTLIGLRArtPAEAAALSGMAQSVGYLLA 353
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 672081819 439 GIAPTVAGFFISQDSefGWRNVFLLAAAIDVVGLLFYLIFGRAEVQD 485
Cdd:COG2807 354 ALGPLLVGALHDATG--SWTAALLLLAALAVLMLVAGLLAGRPYVED 398
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
88-474 |
3.56e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 61.49 E-value: 3.56e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 88 FWNETLQESKAPVydwtpeiqGILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVltLFIPLAAEAGVALLIVL 167
Cdd:cd17475 21 FLQEDLHLSLAQV--------GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGA--AALLMALVGSYPVLLVL 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 168 RVIQGMSQVMVLTGQYSMWAKWAPPLERSQLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFyIFGGIGCACCLLWFPL 247
Cdd:cd17475 91 LFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAF-VVAGLVSILAAVLFWL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 248 VYDDPQnhPFISTGEKryimcslaqedcSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRD 327
Cdd:cd17475 170 FYREPP--AASAATES------------ASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVA 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 328 SGILSALPFMFGCVCIILGGLLADFLLSRNilrlvtiRKLFTALGVLVSSGILVPLPWVSSslSTTMAFLVLSSVFASLC 407
Cdd:cd17475 236 AGALLAVAQLGGALGRIGLGRVSDRVFGGR-------RRPVLVITAAIAAAALLVLSLLSP--GTPLWLLVLLLILLGLF 306
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672081819 408 DSG-ALINFLDIA----PRYAGFLKGLLQVFSYLAGGIAPTVAGFFIsqDSEFGWRNVFLLAAAIDVVGLLF 474
Cdd:cd17475 307 AIGwNGLYLTLVAesagPEQAGTALGLANTINFIGIAIGPPLFGLLV--DATHSYAPAWLALALLLVLAALL 376
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
124-385 |
4.78e-10 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 61.50 E-value: 4.78e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 124 IPTGYVAGVFGAKYVVGLGLLVSSVLTLFipLAAEAGVALLIVLRVIQGMSQVMVLTGQYSMWAKWAPPLERSQLITIAA 203
Cdd:cd17327 59 LPGNLLLQRFPPSKWLSVFIVLWGLLTLL--TAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFY 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 204 SGSMLGTflvlIAGGLLCQAL----------GWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGEKRYIMCSLAQE 273
Cdd:cd17327 137 AAAGLGS----IFGGLLAYGVfkilgvgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRAN 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 274 DCSLG-----WSLPIKAMvKSLPLWAIVVSYFCEYWLLFTIMAYTPTYISS----VLQANLrdsgiLSALPFMFGCVCII 344
Cdd:cd17327 213 QTGKGdqkfkWKQIKEAF-KDPRTWLLFLFFFCSQITNNGISNFLPLILKSlgfySLQTNL-----LSVPIGALGAVSLL 286
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 672081819 345 LGGLLADFLLSRNILrlvtirKLFTALGVLVSSGILVPLPW 385
Cdd:cd17327 287 IAALLSDRFKKRGLF------AIFACVLALVGSIILLAAPN 321
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
121-406 |
7.82e-10 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 60.71 E-value: 7.82e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 121 LAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAEagVALLIVLRVIQGMSQVMVLTGQYSMWAKWAPPLERSQLIT 200
Cdd:cd17328 49 VLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPN--FWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 201 IAASGSMLGTFLVLIAGGLLCQA-LGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGEKRYIMcslaqedcslGW 279
Cdd:cd17328 127 VFYFAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTAT----------SF 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 280 SLPIKAMVKSLPLWAIVVSYFCeywLLFTIMAYT---PTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSR 356
Cdd:cd17328 197 LADLKALAKNPSFILSTLGFTA---VSFVTGALAfwaPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADR 273
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 672081819 357 NILRLVTIRKLFTALGVLVSSGILVPLPWVS-SSLSTTMAFLVLSSVFASL 406
Cdd:cd17328 274 LRRKTPRADPLVCAVGLLAAAPFLFLALVLAlSNLLLAWVLLFLGEFLLSL 324
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
104-476 |
7.66e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 57.60 E-value: 7.66e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 104 TPEIQGILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAeaGVALLIVLRVIQGMSQVMVLTGQY 183
Cdd:cd17489 29 SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT--SVALLLVLRLIHGIGWGAFTTAAA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 184 SMWAKWAPPLERSQLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLLWFpLVYDDPQNHPFISTGEK 263
Cdd:cd17489 107 TLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVF-LVKDPPPVAAEEAEAGT 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 264 RyimcslaqedcSLGWSLPIKAMVKSLPLWAIVVSYfceywllFTIMAYTPTYISSVLQANlrdsgilSALPFMFGCVCI 343
Cdd:cd17489 186 R-----------AFRRLVEKKVLPPALILFLASIAY-------GAISTFLPLYAAERGISN-------AGLFFTVYAIAL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 344 ILGGLLAdfllsrnilrlvtiRKLFTALG---VLVSSGILVPLPWVSSSLSTTMAFLVLSSVFASLcDSGALINFL---- 416
Cdd:cd17489 241 LLSRPFS--------------GKLSDRKGpktVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGL-GFGLLFPALqala 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672081819 417 -DIAPRYA-GFLKGLLQVFSYLAGGIAPTVAGFFIsqdSEFGWRNVFLLAAAIDVVGLLFYL 476
Cdd:cd17489 306 vDLVPPHRrGAANGTFFIFFDLGIGLGGLLLGLVA---ELFGYRAMFLLAAVVVLLALVLYI 364
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
194-450 |
9.16e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 57.60 E-value: 9.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 194 ERSQLITIAASGSMLGTFLVLIAGGLL------CQALGWPYIFYIFGGIGCACCLLwfplvyddpqnhPFISTGEKRYIm 267
Cdd:COG2211 144 ERTRLSSWRFAFAGLGGLLASVLPPPLvaafggDAALGYRLTALIFAVLGLLAFLL------------TFFGTKERPVP- 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 268 cslaqEDCSLGWSLPIKAMVKSLPLWAIVVSYFCeYWL-LFTIMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILG 346
Cdd:COG2211 211 -----EEEKVSLKESLKALLKNRPFLLLLLAYLL-FFLaLALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLW 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 347 GLLADFLLSRNILRLVTIrklFTALGVLV------SSGILVPLPWVSSSLSTTMAFLVLSSVFASLCDSGALINFLdiap 420
Cdd:COG2211 285 PRLAKRFGKKKAFIIGLL---LAALGLLLlfflgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGR---- 357
|
250 260 270
....*....|....*....|....*....|
gi 672081819 421 RYAGFLKGLLQVFSYLAGGIAPTVAGFFIS 450
Cdd:COG2211 358 RREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
118-478 |
1.98e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.04 E-value: 1.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 118 GSFLAPIpTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAeaGVALLIVLRVIQG------MSQVMVLTGQYSmwakwaP 191
Cdd:cd17474 47 AAVLMPV-AGVLADRFGRKKVLLPGLLLFGIGGLLCGLSD--SFALLLAGRALQGigaaglGPLALTLIGDLF------E 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 192 PLERSQLITIAASGSMLGTFLVLIAGGLLCqALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGEKRyimcsla 271
Cdd:cd17474 118 GGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLR------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 272 qedcslgwsLPIKAMvKSLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFGCV-CIILGGLLA 350
Cdd:cd17474 190 ---------DLKKAL-RGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALgSLFVGRLLK 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 351 DFLLSRNILrlvtirklftALGVLVSSGILVPLPWVssslsTTMAFLVLSSVFASLCD-------SGALINFLDIAPRya 423
Cdd:cd17474 260 KRFGARRIL----------VIGLLLYALSLLLLGFV-----PSLALLLIAIVLFGLGLglnlpllTTLVTELAPEEER-- 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 672081819 424 GFLKGLLQVFSYLAGGIAPTVAGFFIsqdSEFGWRNVFLLAAAIDVVGLLFYLIF 478
Cdd:cd17474 323 GTASSLYNFVRFLGQAVGPLLFGLLL---EIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
114-477 |
2.81e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 55.64 E-value: 2.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 114 SLNYGSFLapIPTGYVAGVFGAK--YVVGLGL-LVSSVLTLFIPlaaeaGVALLIVLRVIQGMSQVMVLTGQYSMWAKWA 190
Cdd:cd17321 41 LLAFAALL--LLAGRLGDRFGRKrvFLIGLALfGLASLLCALAP-----SLAFLIAARALQGIGAAAIMPASLALIAATF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 191 PPLERSQLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLLwfplvyddpqnhpfistgekryimcsl 270
Cdd:cd17321 114 PGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL--------------------------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 271 aqedcslgwslpikamvkSLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSaLPFMFGC-VCIILGGLL 349
Cdd:cd17321 167 ------------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLAL-LPLALAMlVAAPLAGRL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 350 ADFLLSRNILRLVTirkLFTALGVLVSSGILVPLPWVSSSLSTTMAFLVLSSVFASLcdSGALINFLDiaPRYAGFLKGL 429
Cdd:cd17321 228 ADRFGPRLVLVAGL---LLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPL--TNAALSSVP--KEKAGAASGI 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672081819 430 LQVFSYLAGGIAPTVAGFFIS--------------------QDSEFGWRNVFLLAAAIDVVGLLFYLI 477
Cdd:cd17321 301 LNTARQLGGALGVALLGALLTaglsanlgdsgvaallsaaaAAFAAGFHLAFLVAAALALLAALLALL 368
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
108-402 |
3.45e-08 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 55.39 E-value: 3.45e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 108 QGILLSSLNY-----GSFLAPIptgyVAGVFGAKYVVGLGLLVSSVLTLFIPLAAeaGVALLIVLRVIQGMSQVMVLTGQ 182
Cdd:cd06180 35 QAGWIATANYagylvGALLASF----LRRRGRARRLIRGGLLLTVLLLAAMALTS--GFAALLALRFLAGAASAFVFVFG 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 183 YSMWAKWAPPLERSQLITIAASGSMLGTFLV-LIAGGLLCQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTG 261
Cdd:cd06180 109 SNLVLHHATAAGRGHLIGLLFAGVGLGIALSgLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAA 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 262 EKRyimcslaqedcslgwslpikaMVKSLPLWAIVVSYFCEYWLLFTIMAYTPTYissvlqanLRDSGILSALPFMFGCV 341
Cdd:cd06180 189 ESA---------------------PGLNRPLWRLALAYGLFGFGYIITATFLPLI--------ARETGAGSLLAGLLWSL 239
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672081819 342 cIILGGLLADFLLSRNILRLVTIRKLFTALGVLvSSGILVPLpwvsssLSTTMAFLVLSSV 402
Cdd:cd06180 240 -FGLAAVPSCFLWGALSDRWGTRRALAANLLVQ-AVGVLLPL------LSPGPAGLVLSAV 292
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
109-477 |
4.38e-08 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 55.02 E-value: 4.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 109 GILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAEAGVALLIVLRVIQGMSQVMVLTGQY--SMW 186
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFvgALF 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 187 AKWAPplerSQLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFISTGEKRYi 266
Cdd:cd17333 114 EESSA----TRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVGAF- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 267 mcslaqedcslgwSLPIKAMVKSLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILG 346
Cdd:cd17333 189 -------------SASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 347 GLLADFLLSRNILRLVTIRKLFTALGVLVSSGILVPLpwvsssLSTTMAFLVLSSVFASlcdsgALINFLDIAPRYAGFL 426
Cdd:cd17333 256 GPISRRIKPHTLLVLSGSGALLGLLILLLAPTLVVGL------VATALLGLFMAALFPT-----ILSLGISNLPYAKGKG 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 672081819 427 KGLLQVFSYLAGGIAPTVAGFFisqDSEFGWRNVFLLAAAIDVVGLLFYLI 477
Cdd:cd17333 325 TSVLLAAGSIGGAIIPFIMGFI---AEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
295-478 |
9.82e-08 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 53.96 E-value: 9.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 295 IVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRNILrlvtirklftaLGVL 374
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVL-----------LIGL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 375 VSSGILVPLPWVSSSLSTTMAFLVLSSVFASLCDSGALINFLDIAPRYA-GFLKGLLQVFSYLAGGIAPTVAGFFISQds 453
Cdd:pfam07690 70 LLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEErGRALGLVSAGFGLGAALGPLLGGLLASL-- 147
|
170 180
....*....|....*....|....*
gi 672081819 454 eFGWRNVFLLAAAIDVVGLLFYLIF 478
Cdd:pfam07690 148 -FGWRAAFLILAILSLLAAVLLLLP 171
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
109-246 |
1.58e-07 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 50.34 E-value: 1.58e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 109 GILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTlfIPLAAEAGVALLIVLRVIQGMSQVMVLTGQYSMWAK 188
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLST--AMFALSSNITVLIIARFLQGFGAAFALVAGAALIAD 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672081819 189 WAPPLERSQLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYI---FGGIGCACCLLWFP 246
Cdd:TIGR00880 79 IYPPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFlaiLALAAFILLAFLLP 139
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
101-477 |
5.39e-07 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 51.86 E-value: 5.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 101 YDWTPEIQGILLS--SLNYGsfLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIP--LAAEAGVALLIVLRVIQGMSQV 176
Cdd:cd17345 33 YGLSKTEIGLIGSalSIAYG--LSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGfvPSATSSVGLMFILLFLNGWFQG 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 177 MVLTGQYSMWAKWAPPLERSQLITIAASGSMLGTFLV--LIAGGLLCQALGWPYIFYIFGGIGC---ACCLLWfpLVYDD 251
Cdd:cd17345 111 MGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVgpLAGLGLAIFGDGWWRGAFIFPAIIAiivAVIVLF--LGKDT 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 252 PQNH--PFIST--GEKRYIMCSLAQEDCSLGWSLPIKAMVKSLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRD 327
Cdd:cd17345 189 PESEglPPIEEykGDYPEEADGEEEEQELSAWEIFVKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQ 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 328 SGILSALPFMFGCVCIILGGLLADFLLSRNILRLVTIRKLFTALGVLVSSgiLVPLPWVSSSLSTTMAFLVLSSVFaslc 407
Cdd:cd17345 269 AMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGIIFMILVIVALIVYW--LAPNVLVDLIALIALGFLIYGPVM---- 342
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672081819 408 dsgaLINF--LDIAPRYA-GFLKGLLQVFSYLAGGIAPTVAGFFISQdsEFGWRNVFLLAAAIDVVGLLFYLI 477
Cdd:cd17345 343 ----LIGLqaLELVPKKAaGTAAGLTGLFGYLGGSVLATALIGIIVD--HFGWNGGFIVLLASCILAIIFLAL 409
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
108-476 |
1.61e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 50.25 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 108 QGILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAaeAGVALLIVLRVIQGMS------QVMVLTG 181
Cdd:cd17478 33 AGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFA--PNYWLLLLLVALAGIGsaafhpEGARLAS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 182 QYSmwakwapPLERSQLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLLWFPLvyddpqnhpfistg 261
Cdd:cd17478 111 QAA-------GGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRL-------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 262 eKRYIMCSLAQEDCSLGWSLPIKAMVKSL-PLWAIVvsyFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALpFMFGC 340
Cdd:cd17478 170 -RPLKKPEAKKAAAKSSARSTLKGVWRALlLLLIIV---FLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLF-LFAGA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 341 VCIILGGLLADFLLSRNILRLVTIRKLFTALGVLVSSGILvplpwvssslstTMAFLVLSSVFASLCDSGALINFLDIAP 420
Cdd:cd17478 245 IGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIW------------SYILLVLAGFLLFASFPVTVVLAQELLP 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 672081819 421 RYAGFLKGLLQVFSYLAGGIAPTVAGFFISQdseFGWRNVFLLAAAIDVVGLLFYL 476
Cdd:cd17478 313 GNVGLASGLMMGLSFGLGGIGAPVLGALADA---FGLESVLLILALLPLLGALLAF 365
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
109-478 |
2.67e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.53 E-value: 2.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 109 GILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAaeAGVALLIVLRVIQGMSQVMVLTGQYSMWAK 188
Cdd:cd17329 38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA--HSPWLFAIALVLTGFGGGLFEPASEAMIAD 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 189 WAPPLERSQLITI--------AASGSMLGTFLVLIAGGLLCQALGWPYIFYIFggigcaccLLWFPLVYDDPQNHPFIST 260
Cdd:cd17329 116 VTTPENRTRAFSLlywainlgVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAAL--------VLLFLLPETRPKRRAAEKT 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 261 GEKRyimcslaqedcslgwslPIKAMVKSLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPfmfGC 340
Cdd:cd17329 188 EILR-----------------GYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALN---AL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 341 VCIILGGLLADFLLSRNILRLVTIRKLFTALGVLVSSGILVPLPWVSSSLSTTMAFLVLSSVFASLCDsgalinflDIAP 420
Cdd:cd17329 248 LIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVA--------ALAP 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 672081819 421 -RYAGFLKGLLQVFSYLAGGIAPTVAGFFISQDSEFGwrnVFLLAAAIDVVGLLFYLIF 478
Cdd:cd17329 320 pDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGL---PWLILAALGLIAAALLLGL 375
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
100-247 |
3.23e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 49.15 E-value: 3.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 100 VYDWTPEIQGILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLfiPLAAEAGVALLIVLRVIQGMSQVMVL 179
Cdd:cd06173 238 VLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALL--VLGLSPSLWLLLAALFLLGLAGGLFN 315
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672081819 180 TGQYSMWAKWAPPLERSQLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLLWFPL 247
Cdd:cd06173 316 VPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
100-245 |
3.28e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 49.11 E-value: 3.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 100 VYDWTPEIQGILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAaeAGVALLIVLRVIQGMSQVMVL 179
Cdd:cd17325 229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA--TSFWLLLLLLALLGLGLGLVF 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 672081819 180 TGQYSMWAKWAPPLERSQLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIgCACCLLWF 245
Cdd:cd17325 307 PATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAAL-LLLAAVLF 371
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
121-410 |
8.93e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 48.02 E-value: 8.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 121 LAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAEaGVALLIVLRVIQGMSQVMVLTGQYSMwAKWAPPLERSQLIT 200
Cdd:cd17341 49 LLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVS-SYWGLLVLGFLLGFAGANFASGQPWA-SFWFPKEKIGGAAG 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 201 IAASGSMLGT-----FLVLIAGG--LLCQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNhpfistgeKRYIMCSLAQe 273
Cdd:cd17341 127 GIAGAGNMGVavsqlLAPLIAGAivFDGGFVGWRNAFFVPGILLAIAAVLVLLFGDDLPTG--------KASALEFLKV- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 274 dcslgwslpIKAMVKSLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFL 353
Cdd:cd17341 198 ---------QLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRF 268
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 672081819 354 LSRNILRLVTIrklftalGVLVSSGILVPLPwvSSSLSTTMAFLVLSSVFASLCDSG 410
Cdd:cd17341 269 GGRRRLWWLFI-------VMTIGAALLSLSL--PTSGTNLVLFLALFVALGLGAGAG 316
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
100-248 |
1.40e-05 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 47.17 E-value: 1.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 100 VYDWTPEIQGILLSSLNYGSFLAPIPTGYVAGVFGA--KYVVGLGLLVSSVLTLFIPLAAeaGVALLIVLRVIQGMSQVM 177
Cdd:COG2271 210 VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLP--SPALAIALLFLAGFGLGG 287
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672081819 178 VLTGQYSMWAKWAPPLERSQLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLLWFPLV 248
Cdd:COG2271 288 AFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
104-473 |
1.41e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.21 E-value: 1.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 104 TPEIQGILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAeaGVALLIVLRVIQGMSQVMVLTGQY 183
Cdd:cd17316 34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLP--TPILLLVLRFLQGIGIGGEYPGAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 184 SMWAKWAPPLERSQLITIAASGSMLGTFLVLIAGGLL----CQALGWPyIFYIFGGIGCACCLLWFPLVyddpqnhpfis 259
Cdd:cd17316 112 TYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLipllSGDWGWR-ILFLIGALPALLALLLRRRT----------- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 260 tgekryimcslaqedcslgwslpikamvkslplWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFG 339
Cdd:cd17316 180 ---------------------------------LLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 340 CVCIILGGLLADFLLsrnilrlvtiRKLFTALGVLVSSGILVPLPWV-SSSLSTTMAFLVLSSVFASLCDSGALINFLDI 418
Cdd:cd17316 227 LVGALIAGLLSDRIG----------RKKTLVIGLILSGILALPLFYLlSGSPTLLLLLLFILSFFVGGVWGALYAYLAEL 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 672081819 419 AP---RYAGFlkGLLQVFSYLAGGIAPTVAGFFISqdSEFGWRNVFLLAAAIDVVGLL 473
Cdd:cd17316 297 FPtevRATGV--GLSYNLGRLGGGGAPPLIALLLA--STGGTGVPALILALLAIVALI 350
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
124-243 |
2.07e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 46.80 E-value: 2.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 124 IP-TGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAEAGValLIVLRVIQGMSQ-VMVLTGQySMWAKWAPPLERSQLITI 201
Cdd:cd17503 48 IPlSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLAS--LIIFRILQGFGGgVLIPLAQ-TILLRIYPPEKRGAAMGL 124
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 672081819 202 AASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLL 243
Cdd:cd17503 125 VGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLL 166
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
114-350 |
2.24e-05 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 46.49 E-value: 2.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 114 SLNYGSFLapIPTGYVAGVFGAK--YVVGLGLLVS-SVLTLFIPlaaeaGVALLIVLRVIQGMSQVMVLTGQYSMWAK-W 189
Cdd:cd17476 43 SLTVGTFI--LIFGRLGDIYGHKkmFVIGSFWFAIwSLIAGFSP-----NFIFFIICRALQGLGPAFLLPNAMALLGRtY 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 190 APPLERSQLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLLwfplvyddpqnHPFISTGEKRYIMCS 269
Cdd:cd17476 116 PPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVA-----------AIFWTSPSFIAVLLA 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 270 LAqedcsLGWSlpikamvkSLPLWAIVVSYFCEYWLLFTIMA----YTPTYISSVLqANLRDSGILSALP----FMFGCV 341
Cdd:cd17476 185 VF-----LGWA--------SFGIWVFYATQYFQNVRGYSPLLtsarFIPMAIGGVL-AAITVGFLIARLPpsyiMAISMV 250
|
....*....
gi 672081819 342 CIILGGLLA 350
Cdd:cd17476 251 AFLVGPILF 259
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
109-422 |
1.57e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 43.88 E-value: 1.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 109 GILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAeaGVALLIVLRVIQG------MSQVMVLTGQ 182
Cdd:TIGR00895 55 GFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALAT--NVTQLLILRFLAGlglgglMPNLNALVSE 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 183 YsmwakwAPPLERSQLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIfGGIGCACCLL----WFP-----LVYDDPQ 253
Cdd:TIGR00895 133 Y------APKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYV-GGIAPLLLLLllmrFLPesidfLVSKRPE 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 254 NHPFISTG---EKRYIMCSLAQEDCSL--GWSLPIKA-----MVKSLPLwaIVVSYFCEYWLLFTIMAYTPtYISSVLQA 323
Cdd:TIGR00895 206 TVRRIVNAiapQMQAEAQSALPEQKSTqgTKRSVFKAlfqgkTARITVL--LWLLYFMLLVGVYFLTNWLP-KLMVELGF 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 324 NLRDSGILSALPFMFGCVCIILGGLLADFLLSRnilrlvtirklfTALGVLVSSGILVPLPWVSSSLSTTMAFLVlssVF 403
Cdd:TIGR00895 283 SLSLAATGGALFNFGGVIGSIIFGWLADRLGPR------------VTALLLLLGAVFAVLVGSTLFSPTLLLLLG---AI 347
|
330
....*....|....*....
gi 672081819 404 ASLCDSGALINFLDIAPRY 422
Cdd:TIGR00895 348 AGFFVNGGQSGLYALMALF 366
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
292-480 |
2.01e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 43.72 E-value: 2.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 292 LWAIVVSYFCEYWLLFTIMAYTPTyISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRNilrlvtirklftal 371
Cdd:COG2223 7 LLLATLAFFLAFGVWYLWSVLAPP-LAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRR-------------- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 372 gVLVSSGILVPLPWVSSSLSTTMAFLVLSSVFASLCDSGALINFLDIA-----PRYAGFLKGLLQVFSYLAGGIAPTVAG 446
Cdd:COG2223 72 -VLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVskwfpPDRRGLALGLAAGGGNLGAAVAAFLAP 150
|
170 180 190
....*....|....*....|....*....|....
gi 672081819 447 FFISQdseFGWRNVFLLAAAIDVVGLLFYLIFGR 480
Cdd:COG2223 151 LLIAA---FGWRNAFLILGILLLVVAVLAWLFLR 181
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
194-448 |
2.42e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 43.36 E-value: 2.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 194 ERSQLITIAASGSMLGTFLVLIAGGLL-------CQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQnhPFISTGEKRYI 266
Cdd:cd17332 133 ERTSLTSWRMFFATIGGLLVTVLPPPLvayfgggNASRGYFLTALIIGIIGIILLLICFFGTRERVV--PPEEEKSKLPL 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 267 MCSLaqedcslgwslpiKAMVKSLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILG 346
Cdd:cd17332 211 LKSL-------------KALLKNRPFLILLLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWP 277
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 347 GLLADFlLSRNILRLVTIRKLFTALGVLVSSGILVPLPWVSSSLS---TTMAFLVLSSVFASLCDSGALINFLDIAPRYA 423
Cdd:cd17332 278 PLKKRF-GKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAgigYGGANLLPWAMLADVIDYGELKTGKRREGIFY 356
|
250 260
....*....|....*....|....*
gi 672081819 424 GFLKGLLQVFSYLAGGIAPTVAGFF 448
Cdd:cd17332 357 SVMTFFRKLGLALAGALVGLILSLA 381
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
121-248 |
3.89e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 42.56 E-value: 3.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 121 LAPIPTGYVAGVFGAKYVVGLGLLVSSVLTlfIPLAAEAGVALLIVLRVIQGMSQVMVL-TGQYSMwAKWAPPLERSQLI 199
Cdd:cd17323 49 LGPLIWAPLSELYGRRPVYLVSLFIFVIFQ--IGCALAPNIAMLIILRFLQGFFGSSPLaIGAGTI-ADLFTPEERGKAM 125
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 672081819 200 TIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCAC---CLLWFPLV 248
Cdd:cd17323 126 GVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFClilIFLFLPIV 177
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
124-255 |
7.08e-04 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 41.98 E-value: 7.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 124 IP-TGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAEagVALLIVLRVIQGMSQVMVLTGQYSMWAKWAPPLERSQLITIA 202
Cdd:TIGR00711 54 IPlTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPN--LELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIW 131
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 672081819 203 ASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLL-WFPLVYDDPQNH 255
Cdd:TIGR00711 132 GLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVaFFILPRDKPAAS 185
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
120-479 |
9.75e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.40 E-value: 9.75e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 120 FLAPIpTGYVAGVFGAKYVVGLGLLVSSVLTLfIPLAAEAgVALLIVLRVIQGMSQVMVLTGQYSMWAKWAPPLERSQLI 199
Cdd:cd17473 50 LFAPL-AGWLADRFGRKRLLIAGLLLYGIGGV-AGLFLDS-LYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKML 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 200 -TIAASGSMLGTFLVLIAGGLLcqALGWPYIFYIFG-GIGCACCLLWFplVYDDPQNHPFISTGEKryimcslaqedcsl 277
Cdd:cd17473 127 gLQSAAMSLGGVVFLLLGGALA--EIGWRAPFLVYLlALPVLILVLLF--LPEPARKSKSAASPGA-------------- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 278 gwslPIKAMVKSLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFGcvciILGGLLADFLLSRn 357
Cdd:cd17473 189 ----ATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAG----AIGALLFGRLKRR- 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 358 ilrlvtIRKLFTALGVLVSSGILVPLPWVSSSLSTTMAFLVLSSVFASLCDSGALINFLDIAPRYA-GFLKGLLQVFSYL 436
Cdd:cd17473 260 ------LGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELrGRAMGIVTSAFFL 333
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 672081819 437 AGGIAPTVAGFFISQdsEFGWRNVFLLAAAIDVVGLLFYLIFG 479
Cdd:cd17473 334 GQFLSPLVLGPLVNL--TGGLSGAFLILGVLALVLAIVLLLLR 374
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
292-478 |
1.22e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 41.01 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 292 LWAIVVSYFCEYWLLFTIMAYTPtYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRNILrlvtirklftAL 371
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAAP-PLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVL----------AI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 372 GVLVSSGILVPLPWVSSsLSTTMAFLVLSSVFASLCDSGALINFLDIAP-RYAGFLKGLLQVFSYLAGGIAPTVAGFFIS 450
Cdd:COG2271 81 GLLLWGLATLLFGFATS-FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPpKERGRALGIFNAGGPLGGALAPPLLGWLLA 159
|
170 180
....*....|....*....|....*...
gi 672081819 451 QdseFGWRNVFLLAAAIDVVGLLFYLIF 478
Cdd:COG2271 160 A---FGWRAAFLILGLPGLLLALLRFWL 184
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
290-490 |
1.38e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 40.99 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 290 LPLWAIVVSYFCeYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRNILRLVTirkLFT 369
Cdd:COG0738 8 RALIAIYLLFFL-WGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL---LLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 370 ALGVLvssgilvpLPWVSSSLSTTMAFLVLSSVFASLCDSGALINFLDIAPRYAGFLKGLLQVFSYLAGGIAPTVAGFFI 449
Cdd:COG0738 84 ALGLL--------LFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLI 155
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 672081819 450 SQDSEFGWRNVFLLAAaidVVGLLFYLIFGRAEVQDWAKEP 490
Cdd:COG0738 156 LLGLSLSWHLPYLILA---VLLLLLALLFLRSKLPEIEEEE 193
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
288-478 |
1.45e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 40.73 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 288 KSLPLWAIVVSYFCEyWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRNILrlvtirkL 367
Cdd:COG2814 8 RWLALLALALGAFLS-GLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL-------L 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 368 FTALGVLVSSGILvplpWVSSSLSTTMAFLVLSSVFASLCDSGALINFLDIAP-RYAGFLKGLLQVFSYLAGGIAPTVAG 446
Cdd:COG2814 80 LGLLLFALGSLLC----ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGG 155
|
170 180 190
....*....|....*....|....*....|..
gi 672081819 447 FFISQdseFGWRNVFLLAAAIDVVGLLFYLIF 478
Cdd:COG2814 156 LLADL---FGWRWVFLVNAVLALLALLLLLRL 184
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
120-478 |
1.73e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.68 E-value: 1.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 120 FLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFIPLAAEAG---VALLIVLRVIQGMSQVMVLTGQYSMWAKWAPPLERS 196
Cdd:cd06173 48 LLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGslsLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLV 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 197 QLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQNHPFIStgekryimcSLAQEDCS 276
Cdd:cd06173 128 RANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESS---------SLLLRDLR 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 277 LGWSLpikaMVKSLPLWAIVVSYFCEYWLLFTIMAYTPTYISSVLQANLRDSGILSALPFmfgcvciiLGGLLADFLLSR 356
Cdd:cd06173 199 EGLRY----LRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFG--------VGALLGALLLGR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 357 NILRLVTIRKLFTALGVLVSSGILVPLpwvSSSLSTTMAFLVLSSVFASLCD--SGALINfLDIAPRYAGFLKGLLQVFS 434
Cdd:cd06173 267 LSKRRRRGRLLLIGALLLGLALLVLGL---SPSLWLLLAALFLLGLAGGLFNvpLNTLLQ-LRVPDELRGRVFSVYNALN 342
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 672081819 435 YLAGGIAPTVAGFFISQdseFGWRNVFLLAAAIDVVGLLFYLIF 478
Cdd:cd06173 343 SGAMPLGALLAGLLADA---LGLSAVFLLAGALLLLAALLLLLL 383
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
292-478 |
2.10e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 40.18 E-value: 2.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 292 LWAIVVSYFCEyWLLFTIMAYTPTYISSVLQANLRDSGILSALPFMFGCVCIILGGLLADFLLSRNILrlvtirkLFTAL 371
Cdd:COG0477 16 LLALALGTFLE-GLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVL-------LIGLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 372 GVLVSSGILVplpwVSSSLSTTMAFLVLSSVFASLCDSGALINFLDIAP-RYAGFLKGLLQVFSYLAGGIAPTVAGFFIS 450
Cdd:COG0477 88 LFGLASLLCG----LAPSPELLIAARALQGIGAGGLMPGALALIAELFPaRERGRALGLWGAAIGLGLALGPLLGGLLVA 163
|
170 180
....*....|....*....|....*...
gi 672081819 451 QdseFGWRNVFLLAAAIDVVGLLFYLIF 478
Cdd:COG0477 164 A---LGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
109-481 |
8.52e-03 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 38.47 E-value: 8.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 109 GILLSSLNYGSFLAPIPTGYVAGVFGAKYVVGLGLLVSSVLTLFipLAAEAGVALLIVLRVIQGMSQVMVLTGQYSMWAK 188
Cdd:cd17343 41 GLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVA--FSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRK 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 189 WAPPLERSQLITIAASGSMLGTFLVLIAGGLLCQALGWPYIFYIFGGIGCACCLLWFPLVYDDPQ--NHPFISTGEKRYI 266
Cdd:cd17343 119 WFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSdvGLNNIEEEESKGK 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 267 MCSLAQEDCSlgwslpIKAMVKSLPLWAIVVSYFCEYWLLFTIMAYTPTY-ISSVLQANLRDSGILSALPfMFGCVCIIL 345
Cdd:cd17343 199 KKKSPRGEST------LKELLLSPFLWLLSLGYLVVFGVKTAVTDWGQLFlIQDKGQSALTGSSFMSSLE-VGGFVGSIA 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672081819 346 GGLLADFLLSRNILRLVTIRKLFTALGVLVSSGILVPLPWVSSSLSTTMAFLVLSSVFASLCDSGALINFLDIAPRYA-G 424
Cdd:cd17343 272 AGYLSDWAVAKHGSSSRGNPRMPLALVFMAGLTVSLHLFRVHITSDSSELFILLLGFLIGFSLYGPIAIFGVIANESApS 351
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 672081819 425 FLKGLLQVFSYLAGGIAPTVAGFFISQ-DSEFGWRNVFLLAAAIDVVGLLFYLIFGRA 481
Cdd:cd17343 352 HLCGTSHAIVALAANVGGVLAGLPFSYiAKHYDWRTAFLLLEILCAITVVILFLLRNI 409
|
|
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