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Conserved domains on  [gi|672074154|ref|XP_008767794|]
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prolargin isoform X1 [Rattus norvegicus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12020562)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
101-300 5.37e-22

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.54  E-value: 5.37e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 101 YLYLQNNFITELPvESFKNATGLRWINLDNNRIRKVDqRVLEKLPGLAFLYMDKNQLEEVPSALPR--NLEQLRLSQNLI 178
Cdd:COG4886  117 SLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNNQI 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 179 SRIPpgvfsklenlllldlqhnrlsdgvfkaDTFQGLKNLMQLNLAHNILRRMPPKVP--PAIHQLYLDSNKIETIPSgy 256
Cdd:COG4886  195 TDLP---------------------------EPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLPE-- 245

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 672074154 257 FKDFPNLAFIRMNYNKLSDrgLPKnSFNISNLLVLHLSHNKISN 300
Cdd:COG4886  246 LGNLTNLEELDLSNNQLTD--LPP-LANLTNLKTLDLSNNQLTD 286
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 239-369 3.41e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 3.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 239 IHQLYLDSNKIETIPSgyFKDFPNLAFIRMNYNKLSD-RGLPKNSfnisNLLVLHLSHNKISNVPAISN--KLEHLYLNN 315
Cdd:cd21340    4 ITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKiENLEFLT----NLTHLYLQNNQIEKIENLENlvNLKKLYLGG 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 672074154 316 NSIEKINGtqicpsnlvafhdfssdLENVPHLRYLRLDGNFLkppiPLDLMMCF 369
Cdd:cd21340   78 NRISVVEG-----------------LENLTNLEELHIENQRL----PPGEKLTF 110
LRRNT smart00013
Leucine rich repeat N-terminal domain;
67-102 4.50e-06

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.08  E-value: 4.50e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 672074154    67 DCPRECYCPPdfpSALYCDSRNLRKVPIIPPRIHYL 102
Cdd:smart00013   1 ACPAPCNCSG---TAVDCSGRGLTEVPLDLPPDTTL 33
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
101-300 5.37e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.54  E-value: 5.37e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 101 YLYLQNNFITELPvESFKNATGLRWINLDNNRIRKVDqRVLEKLPGLAFLYMDKNQLEEVPSALPR--NLEQLRLSQNLI 178
Cdd:COG4886  117 SLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNNQI 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 179 SRIPpgvfsklenlllldlqhnrlsdgvfkaDTFQGLKNLMQLNLAHNILRRMPPKVP--PAIHQLYLDSNKIETIPSgy 256
Cdd:COG4886  195 TDLP---------------------------EPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLPE-- 245

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 672074154 257 FKDFPNLAFIRMNYNKLSDrgLPKnSFNISNLLVLHLSHNKISN 300
Cdd:COG4886  246 LGNLTNLEELDLSNNQLTD--LPP-LANLTNLKTLDLSNNQLTD 286
LRR_8 pfam13855
Leucine rich repeat;
97-157 3.64e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 3.64e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672074154   97 PRIHYLYLQNNFITELPVESFKNATGLRWINLDNNRIRKVDQRVLEKLPGLAFLYMDKNQL 157
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
128-348 4.15e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.25  E-value: 4.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 128 LDNNRIRKVDqrvlEKLPG-LAFLYMDKNQLEEVPSALPRNLEQLRLSQNLISRIPPGVFSKLENLLLLdlqHNRLSdgv 206
Cdd:PRK15370 206 LDNNELKSLP----ENLQGnIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSLDLF---HNKIS--- 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 207 FKADTFQglKNLMQLNLAHNILRRMPPKVPPAIHQLYLDSNKI----ETIPsgyfkdfPNLAFIRMNYNKLSD--RGLPk 280
Cdd:PRK15370 276 CLPENLP--EELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLtalpETLP-------PGLKTLEAGENALTSlpASLP- 345

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672074154 281 nsfniSNLLVLHLSHNKISNVP-AISNKLEHLYLNNNSIekINGTQICPSNLVAFHDFSSDL----ENVPHLR 348
Cdd:PRK15370 346 -----PELQVLDVSKNQITVLPeTLPPTITTLDVSRNAL--TNLPENLPAALQIMQASRNNLvrlpESLPHFR 411
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 98-355 8.48e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.26  E-value: 8.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154  98 RIHYLYLQNNFITELPV-ESFKNatgLRWINLDNNRIRKVDQrvLEKLPGLAFLYMDKNQLEEVP--SALpRNLEQLRLS 174
Cdd:cd21340    3 RITHLYLNDKNITKIDNlSLCKN---LKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEnlENL-VNLKKLYLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 175 QNLISRIppgvfsklenlllldlqhnrlsDGvfkadtFQGLKNLMQLNLAHNilrRMPPKvppaiHQLYLDSNKIETIps 254
Cdd:cd21340   77 GNRISVV----------------------EG------LENLTNLEELHIENQ---RLPPG-----EKLTFDPRSLAAL-- 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 255 gyfkdfpnlafirmnynklsdrglpKNSfnisnLLVLHLSHNKISNVPAISN--KLEHLYLNNNSIEKingtqicpsnlv 332
Cdd:cd21340  119 -------------------------SNS-----LRVLNISGNNIDSLEPLAPlrNLEQLDASNNQISD------------ 156

                        250       260
                 ....*....|....*....|...
gi 672074154 333 aFHDFSSDLENVPHLRYLRLDGN 355
Cdd:cd21340  157 -LEELLDLLSSWPSLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 239-369 3.41e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 3.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 239 IHQLYLDSNKIETIPSgyFKDFPNLAFIRMNYNKLSD-RGLPKNSfnisNLLVLHLSHNKISNVPAISN--KLEHLYLNN 315
Cdd:cd21340    4 ITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKiENLEFLT----NLTHLYLQNNQIEKIENLENlvNLKKLYLGG 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 672074154 316 NSIEKINGtqicpsnlvafhdfssdLENVPHLRYLRLDGNFLkppiPLDLMMCF 369
Cdd:cd21340   78 NRISVVEG-----------------LENLTNLEELHIENQRL----PPGEKLTF 110
LRRNT smart00013
Leucine rich repeat N-terminal domain;
67-102 4.50e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.08  E-value: 4.50e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 672074154    67 DCPRECYCPPdfpSALYCDSRNLRKVPIIPPRIHYL 102
Cdd:smart00013   1 ACPAPCNCSG---TAVDCSGRGLTEVPLDLPPDTTL 33
LRR_8 pfam13855
Leucine rich repeat;
286-355 8.05e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 8.05e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672074154  286 SNLLVLHLSHNKISNVPAIS----NKLEHLYLNNNSIEKINGtqicpsnlVAFHDFssdlenvPHLRYLRLDGN 355
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfkglSNLKVLDLSNNLLTTLSP--------GAFSGL-------PSLRYLDLSGN 59
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 67-97 8.59e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.45  E-value: 8.59e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 672074154   67 DCPRECYCPPdfpSALYCDSRNLRKVPIIPP 97
Cdd:pfam01462   1 ACPVPCHCSA---TVVNCSDRGLTAVPRDLP 28
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
101-300 5.37e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 96.54  E-value: 5.37e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 101 YLYLQNNFITELPvESFKNATGLRWINLDNNRIRKVDqRVLEKLPGLAFLYMDKNQLEEVPSALPR--NLEQLRLSQNLI 178
Cdd:COG4886  117 SLDLSGNQLTDLP-EELANLTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNltNLKELDLSNNQI 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 179 SRIPpgvfsklenlllldlqhnrlsdgvfkaDTFQGLKNLMQLNLAHNILRRMPPKVP--PAIHQLYLDSNKIETIPSgy 256
Cdd:COG4886  195 TDLP---------------------------EPLGNLTNLEELDLSGNQLTDLPEPLAnlTNLETLDLSNNQLTDLPE-- 245

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 672074154 257 FKDFPNLAFIRMNYNKLSDrgLPKnSFNISNLLVLHLSHNKISN 300
Cdd:COG4886  246 LGNLTNLEELDLSNNQLTD--LPP-LANLTNLKTLDLSNNQLTD 286
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
104-358 9.21e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.07  E-value: 9.21e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 104 LQNNFITELPVESFKNATGLRWINLDNNRIrkvdqrvLEKLPGLAFLYMDKNQLEEVPSALPR--NLEQLRLSQNLISRI 181
Cdd:COG4886   79 LLLLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDL 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 182 PPgvfsklenlllldlqhnrlsdgvfkadTFQGLKNLMQLNLAHNILRRMPPKVP--PAIHQLYLDSNKIETIPSGyFKD 259
Cdd:COG4886  152 PE---------------------------PLGNLTNLKSLDLSNNQLTDLPEELGnlTNLKELDLSNNQITDLPEP-LGN 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 260 FPNLAFIRMNYNKLSDrgLPKNSFNISNLLVLHLSHNKISNVPAISN--KLEHLYLNNNSIEKIngtqicpsnlvafhdf 337
Cdd:COG4886  204 LTNLEELDLSGNQLTD--LPEPLANLTNLETLDLSNNQLTDLPELGNltNLEELDLSNNQLTDL---------------- 265

                        250       260
                 ....*....|....*....|.
gi 672074154 338 sSDLENVPHLRYLRLDGNFLK 358
Cdd:COG4886  266 -PPLANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
97-353 1.41e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.58  E-value: 1.41e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154  97 PRIHYLYLQNNFITELPvESFKNATGLRWINLDNNRIRKVDQrVLEKLPGLAFLYMDKNQLEEVPSALPR--NLEQLRLS 174
Cdd:COG4886  159 TNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLS 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 175 QNLISRIPpgvfsklenlllldlqhnrlsdgvfkadTFQGLKNLMQLNLAHNILRRMPPKVP-PAIHQLYLDSNKIETIP 253
Cdd:COG4886  237 NNQLTDLP----------------------------ELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLK 288

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 254 ----SGYFKDFPNLAFIRMNYNKLSDRGLPKNSFNISNLLVLHLSHNKISNVPAISNKLEHLYLNNNSIEKINGTQICPS 329
Cdd:COG4886  289 lkelELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLT 368

                        250       260
                 ....*....|....*....|....
gi 672074154 330 NLVAFHDFSSDLENVPHLRYLRLD 353
Cdd:COG4886  369 LGLLGLLEATLLTLALLLLTLLLL 392
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
140-358 6.38e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.58  E-value: 6.38e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 140 VLEKLPGLAFLYMDKNQLEEVPSALPRNLEQLRLSQNLISRIPPGVFSKLENLLLLDLQHNRLSDGVFKADTFQGLKNLM 219
Cdd:COG4886   20 LLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 220 QLNLAHNI-----------------LRRMPPKVP--PAIHQLYLDSNKIETIPSGyFKDFPNLAFIRMNYNKLSDrgLPK 280
Cdd:COG4886  100 ELDLSGNEelsnltnlesldlsgnqLTDLPEELAnlTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTD--LPE 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 281 NSFNISNLLVLHLSHNKISNVP-AISN--KLEHLYLNNNSIEkingtqicpsnlvafhDFSSDLENVPHLRYLRLDGNFL 357
Cdd:COG4886  177 ELGNLTNLKELDLSNNQITDLPePLGNltNLEELDLSGNQLT----------------DLPEPLANLTNLETLDLSNNQL 240


                 .
gi 672074154 358 K 358
Cdd:COG4886  241 T 241
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
97-331 5.47e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.41  E-value: 5.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154  97 PRIHYLYLQNNFITELPvESFKNATGLRWINLDNNRIRKVDQrVLEKLPGLAFLYMDKNQLEEVP--SALPrNLEQLRLS 174
Cdd:COG4886  182 TNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPelGNLT-NLEELDLS 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 175 QNLISRIPPgvFSKLENLLLLDLQHNRLSDGVFKADTFQGLKNLMQLNLAHNILRRMPPKVPPAIHQLYLDSNKIETIP- 253
Cdd:COG4886  259 NNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVt 336

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672074154 254 SGYFKDFPNLAFIRMNYNKLSDRGLPKNSFNISNLLVLHLSHNKISNVPAISNKLEHLYLNNNSIEKINGTQICPSNL 331
Cdd:COG4886  337 LTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
LRR_8 pfam13855
Leucine rich repeat;
97-157 3.64e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 3.64e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672074154   97 PRIHYLYLQNNFITELPVESFKNATGLRWINLDNNRIRKVDQRVLEKLPGLAFLYMDKNQL 157
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
128-348 4.15e-10

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.25  E-value: 4.15e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 128 LDNNRIRKVDqrvlEKLPG-LAFLYMDKNQLEEVPSALPRNLEQLRLSQNLISRIPPGVFSKLENLLLLdlqHNRLSdgv 206
Cdd:PRK15370 206 LDNNELKSLP----ENLQGnIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQSLDLF---HNKIS--- 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 207 FKADTFQglKNLMQLNLAHNILRRMPPKVPPAIHQLYLDSNKI----ETIPsgyfkdfPNLAFIRMNYNKLSD--RGLPk 280
Cdd:PRK15370 276 CLPENLP--EELRYLSVYDNSIRTLPAHLPSGITHLNVQSNSLtalpETLP-------PGLKTLEAGENALTSlpASLP- 345

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 672074154 281 nsfniSNLLVLHLSHNKISNVP-AISNKLEHLYLNNNSIekINGTQICPSNLVAFHDFSSDL----ENVPHLR 348
Cdd:PRK15370 346 -----PELQVLDVSKNQITVLPeTLPPTITTLDVSRNAL--TNLPENLPAALQIMQASRNNLvrlpESLPHFR 411
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 98-355 8.48e-10

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 58.26  E-value: 8.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154  98 RIHYLYLQNNFITELPV-ESFKNatgLRWINLDNNRIRKVDQrvLEKLPGLAFLYMDKNQLEEVP--SALpRNLEQLRLS 174
Cdd:cd21340    3 RITHLYLNDKNITKIDNlSLCKN---LKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEnlENL-VNLKKLYLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 175 QNLISRIppgvfsklenlllldlqhnrlsDGvfkadtFQGLKNLMQLNLAHNilrRMPPKvppaiHQLYLDSNKIETIps 254
Cdd:cd21340   77 GNRISVV----------------------EG------LENLTNLEELHIENQ---RLPPG-----EKLTFDPRSLAAL-- 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 255 gyfkdfpnlafirmnynklsdrglpKNSfnisnLLVLHLSHNKISNVPAISN--KLEHLYLNNNSIEKingtqicpsnlv 332
Cdd:cd21340  119 -------------------------SNS-----LRVLNISGNNIDSLEPLAPlrNLEQLDASNNQISD------------ 156

                        250       260
                 ....*....|....*....|...
gi 672074154 333 aFHDFSSDLENVPHLRYLRLDGN 355
Cdd:cd21340  157 -LEELLDLLSSWPSLRELDLTGN 178
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
74-345 2.16e-09

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 59.02  E-value: 2.16e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154  74 CPPDFPSALYCDSRNLRKVPIIPPRIHYLYLQNNFITELPVEsfknATGLRWINLDNNRIRKvdqrvLEKLP-GLAFLYM 152
Cdd:PRK15387 219 CLPAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVL----PPGLLELSIFSNPLTH-----LPALPsGLCKLWI 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 153 DKNQLEEVPsALPRNLEQLRLSQNLISRIP--PGVFSKLENLLLLDLQHNRLSDGvfkadtfqglknLMQLNLAHNILRR 230
Cdd:PRK15387 290 FGNQLTSLP-VLPPGLQELSVSDNQLASLPalPSELCKLWAYNNQLTSLPTLPSG------------LQELSVSDNQLAS 356

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 231 MpPKVPPAIHQLYLDSNKIETIPSgyfkdfpnlafirmnynklsdrgLPknsfniSNLLVLHLSHNKISNVPAISNKLEH 310
Cdd:PRK15387 357 L-PTLPSELYKLWAYNNRLTSLPA-----------------------LP------SGLKELIVSGNRLTSLPVLPSELKE 406

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 672074154 311 LYLNNNsieKINGTQICPSNLVAFHDFSSDLENVP 345
Cdd:PRK15387 407 LMVSGN---RLTSLPMLPSGLLSLSVYRNQLTRLP 438
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 84-296 2.23e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.01  E-value: 2.23e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154  84 CDSRNLRKVPI--------IPP------RIHYLYLQNN-FITELPVEsFKNATGLRWINLDNNRIR-KVDQRVLEkLPGL 147
Cdd:PLN00113 377 CSSGNLFKLILfsnslegeIPKslgacrSLRRVRLQDNsFSGELPSE-FTKLPLVYFLDISNNNLQgRINSRKWD-MPSL 454

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 148 AFLYMDKNQ-LEEVP-SALPRNLEQLRLSQNLISRIPPGVFSKLENLLLLDLQHNRLSDGVfkADTFQGLKNLMQLNLAH 225
Cdd:PLN00113 455 QMLSLARNKfFGGLPdSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEI--PDELSSCKKLVSLDLSH 532

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672074154 226 NILRrmppkvppaihqlyldsnkiETIPSGyFKDFPNLAFIRMNYNKLSDRgLPKNSFNISNLLVLHLSHN 296
Cdd:PLN00113 533 NQLS--------------------GQIPAS-FSEMPVLSQLDLSQNQLSGE-IPKNLGNVESLVQVNISHN 581
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
75-276 9.84e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.93  E-value: 9.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154  75 PPDFPSAL-YCD--SRNLRKVPI-IPPRIHYLYLQNNFITELPvesfknatglrwinldnnrirkvdqrvlEKLP-GLAF 149
Cdd:PRK15370 278 PENLPEELrYLSvyDNSIRTLPAhLPSGITHLNVQSNSLTALP----------------------------ETLPpGLKT 329

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 150 LYMDKNQLEEVPSALPRNLEQLRLSQNLISRIPpgvfsklenlllldlqhnrlsdgvfkaDTFQglKNLMQLNLAHNILR 229
Cdd:PRK15370 330 LEAGENALTSLPASLPPELQVLDVSKNQITVLP---------------------------ETLP--PTITTLDVSRNALT 380

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 672074154 230 RMPPKVPPAIHQLYLDSNKI----ETIPSgYFKDFPNLAFIRMNYNKLSDR 276
Cdd:PRK15370 381 NLPENLPAALQIMQASRNNLvrlpESLPH-FRGEGPQPTRIIVEYNPFSER 430
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 239-369 3.41e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.47  E-value: 3.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 239 IHQLYLDSNKIETIPSgyFKDFPNLAFIRMNYNKLSD-RGLPKNSfnisNLLVLHLSHNKISNVPAISN--KLEHLYLNN 315
Cdd:cd21340    4 ITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKiENLEFLT----NLTHLYLQNNQIEKIENLENlvNLKKLYLGG 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 672074154 316 NSIEKINGtqicpsnlvafhdfssdLENVPHLRYLRLDGNFLkppiPLDLMMCF 369
Cdd:cd21340   78 NRISVVEG-----------------LENLTNLEELHIENQRL----PPGEKLTF 110
LRRNT smart00013
Leucine rich repeat N-terminal domain;
67-102 4.50e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 43.08  E-value: 4.50e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 672074154    67 DCPRECYCPPdfpSALYCDSRNLRKVPIIPPRIHYL 102
Cdd:smart00013   1 ACPAPCNCSG---TAVDCSGRGLTEVPLDLPPDTTL 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 106-366 4.52e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 4.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 106 NNFITELPVEsFKNATGLRWINLDNNRIRKVDQRVLEKLPGLAFLYMDKNQLE-EVPSALP--RNLEQLRLSQNLIS-RI 181
Cdd:PLN00113 198 NQLVGQIPRE-LGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSLGnlKNLQYLFLYQNKLSgPI 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 182 PPGVFsklenlllldlqhnrlsdgvfkadtfqGLKNLMQLNLAHNILRrmpPKVPPAIHQ------LYLDSNKIE-TIPS 254
Cdd:PLN00113 277 PPSIF---------------------------SLQKLISLDLSDNSLS---GEIPELVIQlqnleiLHLFSNNFTgKIPV 326

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 255 GyFKDFPNLAFIRMNYNKLSDrGLPKNSFNISNLLVLHLSHN----KISNVPAISNKLEHLYLNNNSIEkingTQICPSn 330
Cdd:PLN00113 327 A-LTSLPRLQVLQLWSNKFSG-EIPKNLGKHNNLTVLDLSTNnltgEIPEGLCSSGNLFKLILFSNSLE----GEIPKS- 399

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 672074154 331 lvafhdfssdLENVPHLRYLRLDGNFLKPPIPLDLM 366
Cdd:PLN00113 400 ----------LGACRSLRRVRLQDNSFSGELPSEFT 425
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 97-228 1.06e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154  97 PRIHYLYL-QNNFITELPvESFKnATGLRWINLDNNRIRKVDQRVLEKLPGLAFLYMDKNQLE-EVPSALP--RNLEQLR 172
Cdd:PLN00113 452 PSLQMLSLaRNKFFGGLP-DSFG-SKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDELSscKKLVSLD 529

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 672074154 173 LSQNLISRIPPGVFSKLENLLLLDLQHNRLSDGVFKadTFQGLKNLMQLNLAHNIL 228
Cdd:PLN00113 530 LSHNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPK--NLGNVESLVQVNISHNHL 583
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 97-358 1.86e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.19  E-value: 1.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154  97 PRIHYLYLQNNFITEL---PVESFKNATGLRWINLDNNRirkvdqrvLEKLpGLAFlymdknqLEEVPSALPRNLEQLRL 173
Cdd:cd00116   81 CGLQELDLSDNALGPDgcgVLESLLRSSSLQELKLNNNG--------LGDR-GLRL-------LAKGLKDLPPALEKLVL 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 174 SQNLISrippgvfsklenlllldlqhNRLSDGVfkADTFQGLKNLMQLNLAHNILRrmppkvPPAIHQLYLDsnkietip 253
Cdd:cd00116  145 GRNRLE--------------------GASCEAL--AKALRANRDLKELNLANNGIG------DAGIRALAEG-------- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 254 sgyFKDFPNLAFIRMNYNKLSDRG-------LPKNSFnisnLLVLHLSHNKISNVPA---------ISNKLEHLYLNNNS 317
Cdd:cd00116  189 ---LKANCNLEVLDLNNNGLTDEGasalaetLASLKS----LEVLNLGDNNLTDAGAaalasallsPNISLLTLSLSCND 261

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 672074154 318 IEkingtqicpsnLVAFHDFSSDLENVPHLRYLRLDGNFLK 358
Cdd:cd00116  262 IT-----------DDGAKDLAEVLAEKESLLELDLRGNKFG 291
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 89-331 5.62e-05

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 45.25  E-value: 5.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154   89 LRKVPIIPPRIHYLYLQNNFITELPvesfknaTGLRWINLDN-----NRIRKVDQRV--LEKL-----PGLAFLYMDKNQ 156
Cdd:PLN03210  717 LKSFPDISTNISWLDLDETAIEEFP-------SNLRLENLDElilceMKSEKLWERVqpLTPLmtmlsPSLTRLFLSDIP 789

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154  157 -LEEVPSALpRNLEQL-RLS----QNLISrIPPGVfsklenlllldlqhnrlsdgvfkadtfqGLKNLMQLNLAHNILRR 230
Cdd:PLN03210  790 sLVELPSSI-QNLHKLeHLEiencINLET-LPTGI----------------------------NLESLESLDLSGCSRLR 839

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154  231 MPPKVPPAIHQLYLDSNKIETIPSgYFKDFPNLAFIRMNynklSDRGLPKNSFNISNLlvLHLSHNKISNVPAISnkleH 310
Cdd:PLN03210  840 TFPDISTNISDLNLSRTGIEEVPW-WIEKFSNLSFLDMN----GCNNLQRVSLNISKL--KHLETVDFSDCGALT----E 908

                         250       260
                  ....*....|....*....|.
gi 672074154  311 LYLNNNSIEKINGTQICPSNL 331
Cdd:PLN03210  909 ASWNGSPSEVAMATDNIHSKL 929
LRR_8 pfam13855
Leucine rich repeat;
286-355 8.05e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 8.05e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672074154  286 SNLLVLHLSHNKISNVPAIS----NKLEHLYLNNNSIEKINGtqicpsnlVAFHDFssdlenvPHLRYLRLDGN 355
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfkglSNLKVLDLSNNLLTTLSP--------GAFSGL-------PSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
242-298 8.30e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 8.30e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 672074154  242 LYLDSNKIETIPSGYFKDFPNLAFIRMNYNKLSdrGLPKNSF-NISNLLVLHLSHNKI 298
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFsGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 97-365 1.10e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 1.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154  97 PRIHYLYLQNNFIT-ELPVESFKNATGLRWINLDNNrirkvdqrvleklpglaflymdkNQLEEVPSALPRNLEQLRLSQ 175
Cdd:PLN00113  93 PYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNN-----------------------NFTGSIPRGSIPNLETLDLSN 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 176 NLIS-RIP-----------------------PGVFSKLENLLLLDLQHNRLSDGVfkADTFQGLKNLMQLNLAHNILRrm 231
Cdd:PLN00113 150 NMLSgEIPndigsfsslkvldlggnvlvgkiPNSLTNLTSLEFLTLASNQLVGQI--PRELGQMKSLKWIYLGYNNLS-- 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 232 pPKVPPAIHQL----YLD---SNKIETIPSGyFKDFPNLAFIRMNYNKLSDRgLPKNSFNISNLLVLHLSHNKIS-NVPA 303
Cdd:PLN00113 226 -GEIPYEIGGLtslnHLDlvyNNLTGPIPSS-LGNLKNLQYLFLYQNKLSGP-IPPSIFSLQKLISLDLSDNSLSgEIPE 302

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 304 ISNKLEhlylnnnsiekingtqicpsNLVAFHDFSSD--------LENVPHLRYLRLDGNFLKPPIPLDL 365
Cdd:PLN00113 303 LVIQLQ--------------------NLEILHLFSNNftgkipvaLTSLPRLQVLQLWSNKFSGEIPKNL 352
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
216-357 1.15e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 44.30  E-value: 1.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 216 KNLMQLNLAHNILRRMPPKVPPAIHQLYLDSNKIETIPSGYFKDFPNLAFIRMNYNKLSDRgLPknsfniSNLLVLHLSH 295
Cdd:PRK15370 199 EQITTLILDNNELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITELPER-LP------SALQSLDLFH 271

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672074154 296 NKISNVP-AISNKLEHLYLNNNSIEKIngTQICPSNLVAFHDFSSDLENVP-----HLRYLRLDGNFL 357
Cdd:PRK15370 272 NKISCLPeNLPEELRYLSVYDNSIRTL--PAHLPSGITHLNVQSNSLTALPetlppGLKTLEAGENAL 337
LRR_8 pfam13855
Leucine rich repeat;
198-249 4.20e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 4.20e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 672074154  198 QHNRLSdgVFKADTFQGLKNLMQLNLAHNILRRMPPKV---PPAIHQLYLDSNKI 249
Cdd:pfam13855   9 SNNRLT--SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAfsgLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 95-372 8.06e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 8.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154  95 IPP------RIHYLYL-QNNFITELPVESFkNATGLRWINLDNNRIRKVDQRVLEKLPGLAFLYMDKNQLE-EVP---SA 163
Cdd:PLN00113 252 IPSslgnlkNLQYLFLyQNKLSGPIPPSIF-SLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTgKIPvalTS 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 164 LPRnLEQLRLSQNLISRIPPGVFSKLENLLLLDLQHNRLSDGVfkADTFQGLKNLMQLNLAHNILRRMPPKVPPAIHQL- 242
Cdd:PLN00113 331 LPR-LQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEI--PEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLr 407

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 243 --YLDSNKIE-TIPSGYFKdFPNLAFIRMNYNKLSDRgLPKNSFNISNLLVLHLSHNKIS-NVPAI--SNKLEHLYLNNN 316
Cdd:PLN00113 408 rvRLQDNSFSgELPSEFTK-LPLVYFLDISNNNLQGR-INSRKWDMPSLQMLSLARNKFFgGLPDSfgSKRLENLDLSRN 485

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 672074154 317 sieKINGTqiCPSNLVAFhdfssdlenvPHLRYLRLDGNFLKPPIPLDLMMCFRLL 372
Cdd:PLN00113 486 ---QFSGA--VPRKLGSL----------SELMQLKLSENKLSGEIPDELSSCKKLV 526
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 67-97 8.59e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.45  E-value: 8.59e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 672074154   67 DCPRECYCPPdfpSALYCDSRNLRKVPIIPP 97
Cdd:pfam01462   1 ACPVPCHCSA---TVVNCSDRGLTAVPRDLP 28
LRR_8 pfam13855
Leucine rich repeat;
166-226 1.40e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 1.40e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672074154  166 RNLEQLRLSQNLISRIPPGVFSKLENLLLLDLQHNRLSdgVFKADTFQGLKNLMQLNLAHN 226
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT--TLSPGAFSGLPSLRYLDLSGN 59
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 287-323 1.51e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 1.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 672074154  287 NLLVLHLSHNKISNVPAISN--KLEHLYL-NNNSIEKING 323
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKlpNLETLDLsGNNKITDLSD 41
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 97-303 2.65e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 2.65e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154  97 PRIHYLYL-QNNFITELPVESFKNaTGLRWINLDNNRIRKVDQRVLEKLPGLAFLYMDKNQLE-EVPSALP--RNLEQLR 172
Cdd:PLN00113 332 PRLQVLQLwSNKFSGEIPKNLGKH-NNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEgEIPKSLGacRSLRRVR 410

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 173 LSQNLISRIPPGVFSKLENLLLLDLQHNRLSDGVfkADTFQGLKNLMQLNLAHNILRRMPPKVPPA--IHQLYLDSNKI- 249
Cdd:PLN00113 411 LQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRI--NSRKWDMPSLQMLSLARNKFFGGLPDSFGSkrLENLDLSRNQFs 488

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 672074154 250 ETIPSGyFKDFPNLAFIRMNYNKLSDRgLPKNSFNISNLLVLHLSHNKIS-NVPA 303
Cdd:PLN00113 489 GAVPRK-LGSLSELMQLKLSENKLSGE-IPDELSSCKKLVSLDLSHNQLSgQIPA 541
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 89-318 4.92e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 38.62  E-value: 4.92e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154  89 LRKVPIIPPRIHYLYLQNNFITELPVESF----KNATGLRWINLDNNRIRkvDQRVLEKLPGLAF------LYMDKNQLE 158
Cdd:COG5238  200 LAEALTQNTTVTTLWLKRNPIGDEGAEILaealKGNKSLTTLDLSNNQIG--DEGVIALAEALKNnttvetLYLSGNQIG 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 159 E-----VPSALPRN--LEQLRLSQNLIsrippgvfsklenlllldlqhnrlsdgvfkadTFQGLKNLMQlNLAHNilrrm 231
Cdd:COG5238  278 AegaiaLAKALQGNttLTSLDLSVNRI--------------------------------GDEGAIALAE-GLQGN----- 319

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 232 ppkvpPAIHQLYLDSNKIETipSGY------FKDFPNLAFIRMNYNKLSDRG---LPKNSFNISNLLVLHLSHNKISNVP 302
Cdd:COG5238  320 -----KTLHTLNLAYNGIGA--QGAialakaLQENTTLHSLDLSDNQIGDEGaiaLAKYLEGNTTLRELNLGKNNIGKQG 392

                        250       260
                 ....*....|....*....|...
gi 672074154 303 AIS-------NKLEHLYLNNNSI 318
Cdd:COG5238  393 AEAlidalqtNRLHTLILDGNLI 415
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 213-355 6.52e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 38.23  E-value: 6.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 213 QGLKNLMQLNL---------AHNILRRMppKVPPAIHQLYLDSNKI-----ETIPSGyFKDFPNLAFIRMNYNKLSDRG- 277
Cdd:COG5238  233 KGNKSLTTLDLsnnqigdegVIALAEAL--KNNTTVETLYLSGNQIgaegaIALAKA-LQGNTTLTSLDLSVNRIGDEGa 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672074154 278 --LPKNSFNISNLLVLHLSHNKISNVPAIS--------NKLEHLYLNNNSIEKINGTQICPSnlvafhdfssdLENVPHL 347
Cdd:COG5238  310 iaLAEGLQGNKTLHTLNLAYNGIGAQGAIAlakalqenTTLHSLDLSDNQIGDEGAIALAKY-----------LEGNTTL 378


                 ....*...
gi 672074154 348 RYLRLDGN 355
Cdd:COG5238  379 RELNLGKN 386
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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