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Conserved domains on  [gi|672067666|ref|XP_008765986|]
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phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X4 [Rattus norvegicus]

Protein Classification

phosphoribosyl pyrophosphate synthase-associated protein( domain architecture ID 11226557)

phosphoribosyl pyrophosphate synthase-associated protein seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 93-277 3.50e-112

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


:

Pssm-ID: 434046  Cd Length: 184  Bit Score: 321.38  E-value: 3.50e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666   93 DYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPPMVRSvAAIHPSLEIPMLIPKEKPPITVVG 172
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRS-RTVSRSLGLPEIIPKEKPPMTVVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666  173 DVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIPHEIQKLQCPKIKT 252
Cdd:pfam14572  80 DVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKT 159

                         170       180
                  ....*....|....*....|....*
gi 672067666  253 VDISMILSEAIRRIHNGESMSYLFR 277
Cdd:pfam14572 160 IDISQLIAEAIRRIHNGESMSYLFR 184
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 1-52 1.42e-20

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


:

Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 84.39  E-value: 1.42e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 672067666    1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQCKM-RKRGSIVSKLLASMMCKAG 52
Cdd:pfam13793  65 MELLIMIDALKRASAKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
 
Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 93-277 3.50e-112

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 321.38  E-value: 3.50e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666   93 DYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPPMVRSvAAIHPSLEIPMLIPKEKPPITVVG 172
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRS-RTVSRSLGLPEIIPKEKPPMTVVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666  173 DVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIPHEIQKLQCPKIKT 252
Cdd:pfam14572  80 DVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKT 159

                         170       180
                  ....*....|....*....|....*
gi 672067666  253 VDISMILSEAIRRIHNGESMSYLFR 277
Cdd:pfam14572 160 IDISQLIAEAIRRIHNGESMSYLFR 184
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 1-277 7.31e-76

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 233.41  E-value: 7.31e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:COG0462   68 MELLIMIDALKRASARRITAVIPYYGYARQdRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYA 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666  80 SPFLLQYIQEEipDYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPpmvRSVAAIHPSLEI 157
Cdd:COG0462  148 APLLADYIKSK--DLEDLVVV--SPdvGGVKRARAFAKRLGAPLAIIDKR-----------RPGA---NEVEVMNIIGDV 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666 158 pmlipKEKPPItVVGDV---GGriaiivddiiddvdSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVV 234
Cdd:COG0462  210 -----EGKTCI-IVDDMidtGG--------------TLVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSPIDELVV 269

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 672067666 235 TNTIPHEIQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 277
Cdd:COG0462  270 TDTIPLPEEK-RCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
1-277 2.01e-70

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 219.60  E-value: 2.01e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:PRK01259  65 MELLIMIDALKRASAGRITAVIPYFGYARQdRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYG 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666  80 SPFLLQYIQEEipDYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIhgeaqdaesdlvDGRHSPPMVRSVaaihpslei 157
Cdd:PRK01259 145 SPILLEDIKQK--NLENLVVV--SPdvGGVVRARALAKRLDADLAII------------DKRRPRANVSEV--------- 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666 158 pmlipkekppITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNT 237
Cdd:PRK01259 200 ----------MNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKSVYAYATHPVLSGGAIERIENSVIDELVVTDS 269

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 672067666 238 IPHEIQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 277
Cdd:PRK01259 270 IPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLFD 309
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 1-277 5.11e-70

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 218.69  E-value: 5.11e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666    1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRG-SIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:TIGR01251  66 MELLIMIDALKRASAKSITAVIPYYGYARQDKKFKSRePISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYA 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666   80 SPFLLQYIQEEIPDyrNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPPMVRSVAAIhpsleipm 159
Cdd:TIGR01251 146 SPVLAEYLKKKILD--NPVVVSPDAGGVERAKKVADALGCPLAIIDKR-----------RISATNEVEVMNL-------- 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666  160 lipkekppitvVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIP 239
Cdd:TIGR01251 205 -----------VGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGAKRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIP 273

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 672067666  240 HEIqklQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 277
Cdd:TIGR01251 274 HEK---HKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 1-52 1.42e-20

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 84.39  E-value: 1.42e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 672067666    1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQCKM-RKRGSIVSKLLASMMCKAG 52
Cdd:pfam13793  65 MELLIMIDALKRASAKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
 
Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 93-277 3.50e-112

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 321.38  E-value: 3.50e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666   93 DYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDLVDGRHSPPMVRSvAAIHPSLEIPMLIPKEKPPITVVG 172
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRS-RTVSRSLGLPEIIPKEKPPMTVVG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666  173 DVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIPHEIQKLQCPKIKT 252
Cdd:pfam14572  80 DVGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKT 159

                         170       180
                  ....*....|....*....|....*
gi 672067666  253 VDISMILSEAIRRIHNGESMSYLFR 277
Cdd:pfam14572 160 IDISQLIAEAIRRIHNGESMSYLFR 184
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 1-277 7.31e-76

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 233.41  E-value: 7.31e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:COG0462   68 MELLIMIDALKRASARRITAVIPYYGYARQdRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYA 147

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666  80 SPFLLQYIQEEipDYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPpmvRSVAAIHPSLEI 157
Cdd:COG0462  148 APLLADYIKSK--DLEDLVVV--SPdvGGVKRARAFAKRLGAPLAIIDKR-----------RPGA---NEVEVMNIIGDV 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666 158 pmlipKEKPPItVVGDV---GGriaiivddiiddvdSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVV 234
Cdd:COG0462  210 -----EGKTCI-IVDDMidtGG--------------TLVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSPIDELVV 269

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 672067666 235 TNTIPHEIQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 277
Cdd:COG0462  270 TDTIPLPEEK-RCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
1-277 2.01e-70

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 219.60  E-value: 2.01e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:PRK01259  65 MELLIMIDALKRASAGRITAVIPYFGYARQdRKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYG 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666  80 SPFLLQYIQEEipDYRNAVIVakSP--ASAKRAQSFAERLRLGIAVIhgeaqdaesdlvDGRHSPPMVRSVaaihpslei 157
Cdd:PRK01259 145 SPILLEDIKQK--NLENLVVV--SPdvGGVVRARALAKRLDADLAII------------DKRRPRANVSEV--------- 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666 158 pmlipkekppITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNT 237
Cdd:PRK01259 200 ----------MNIIGDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKSVYAYATHPVLSGGAIERIENSVIDELVVTDS 269

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 672067666 238 IPHEIQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 277
Cdd:PRK01259 270 IPLSEEAKKCDKIRVLSVAPLLAEAIRRISNEESVSSLFD 309
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 1-277 5.11e-70

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 218.69  E-value: 5.11e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666    1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRG-SIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:TIGR01251  66 MELLIMIDALKRASAKSITAVIPYYGYARQDKKFKSRePISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYA 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666   80 SPFLLQYIQEEIPDyrNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPPMVRSVAAIhpsleipm 159
Cdd:TIGR01251 146 SPVLAEYLKKKILD--NPVVVSPDAGGVERAKKVADALGCPLAIIDKR-----------RISATNEVEVMNL-------- 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666  160 lipkekppitvVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIP 239
Cdd:TIGR01251 205 -----------VGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGAKRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIP 273

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 672067666  240 HEIqklQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 277
Cdd:TIGR01251 274 HEK---HKPKVSVISVAPLIAEAIRRIHNNESVSSLFD 308
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
1-276 5.44e-52

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 172.81  E-value: 5.44e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRK-RGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLR 78
Cdd:PRK04923  71 MELLVLIDALKRASAASVTAVIPYFGYSRQdRRMRSsRVPITAKVAAKMISAMGADRVLTVDLHADQIQGFFDVPVDNVY 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666  79 ASPFLLQYIQEEIpDYRNAVIVAKSPASAKRAQSFAERLrlgiavihgeaQDAESDLVDGRHSPPMVRSVaaihpsleip 158
Cdd:PRK04923 151 ASPLLLADIWRAY-GTDNLIVVSPDVGGVVRARAVAKRL-----------DDADLAIIDKRRPRANVATV---------- 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666 159 mlipkekppITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTI 238
Cdd:PRK04923 209 ---------MNIIGDVQGKTCVLVDDLVDTAGTLCAAAAALKQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTI 279

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 672067666 239 PHEIQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLF 276
Cdd:PRK04923 280 PLSEAARACAKIRQLSVAELLAETIRRIAFGESVSSLY 317
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
1-276 1.62e-47

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 161.11  E-value: 1.62e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:PRK02269  70 MEILIMVDALKRASAESINVVMPYYGYARQdRKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMG 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666  80 SPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIhgeaqdaesdlvDGRHSppmvrsvaaihpslEIPM 159
Cdd:PRK02269 150 APLIADYFDRRGLVGDDVVVVSPDHGGVTRARKLAQFLKTPIAII------------DKRRS--------------VDKM 203

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666 160 LIPKekpPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIP 239
Cdd:PRK02269 204 NTSE---VMNIIGNVKGKKCILIDDMIDTAGTICHAADALAEAGATEVYASCTHPVLSGPALDNIQKSAIEKLVVLDTIY 280

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 672067666 240 HEIQKLqCPKIKTVDISMILSEAIRRIHNGESMSYLF 276
Cdd:PRK02269 281 LPEERL-IDKIEQISIADLLGEAIIRIHEKRPLSPLF 316
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 1-277 2.45e-47

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 159.86  E-value: 2.45e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:PLN02369  56 MELLIMIDACRRASAKRITAVIPYFGYARAdRKTQGRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPVDHVYG 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666  80 SPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLrlgiavihgeaQDAESDLVDGRHSPpmvrsvaaiHPSLEipm 159
Cdd:PLN02369 136 QPVILDYLASKTISSPDLVVVSPDVGGVARARAFAKKL-----------SDAPLAIVDKRRQG---------HNVAE--- 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666 160 lipkekpPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIP 239
Cdd:PLN02369 193 -------VMNLIGDVKGKVAIMVDDMIDTAGTITKGAALLHQEGAREVYACATHAVFSPPAIERLSSGLFQEVIVTNTIP 265

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 672067666 240 HEIQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 277
Cdd:PLN02369 266 VSEKN-YFPQLTVLSVANLLGETIWRVHDDCSVSSIFD 302
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
1-276 1.20e-45

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 155.49  E-value: 1.20e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:PRK03092  54 MEQLIMIDALKRASAKRITVVLPFYPYARQdKKHRGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPVDHLFA 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666  80 SPFLLQYIQEEIPDyRNAVIVAKSPASAKRAQSFAERLrlgiavihGEAqdaesdlvdgrhspPMvrsvAAIHPSLEIpm 159
Cdd:PRK03092 134 MPLLADYVRDKYDL-DNVTVVSPDAGRVRVAEQWADRL--------GGA--------------PL----AFIHKTRDP-- 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666 160 LIPKEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIP 239
Cdd:PRK03092 185 TVPNQVVANRVVGDVEGRTCVLVDDMIDTGGTIAGAVRALKEAGAKDVIIAATHGVLSGPAAERLKNCGAREVVVTDTLP 264

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 672067666 240 HEIQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLF 276
Cdd:PRK03092 265 IPEEK-RFDKLTVLSIAPLLARAIREVFEDGSVTSLF 300
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 1-277 7.06e-45

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 154.51  E-value: 7.06e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666   1 MELLIMVYACKTSCAKSIIGVIPYFPYSK-QCKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:PRK02812  86 MELLIMVDACRRASARQITAVIPYYGYARaDRKTAGRESITAKLVANLITKAGADRVLAMDLHSAQIQGYFDIPCDHVYG 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666  80 SPFLLQYIQEEipDYRNAVIVAKSPASAKRAQSFAERLRlgiavihgeaqDAESDLVDGRHSPPMVRSVaaihpsleipm 159
Cdd:PRK02812 166 SPVLLDYLASK--NLEDIVVVSPDVGGVARARAFAKKLN-----------DAPLAIIDKRRQAHNVAEV----------- 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666 160 lipkekppITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIP 239
Cdd:PRK02812 222 --------LNVIGDVKGKTAILVDDMIDTGGTICEGARLLRKEGAKQVYACATHAVFSPPAIERLSSGLFEEVIVTNTIP 293

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 672067666 240 HEiQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLFR 277
Cdd:PRK02812 294 VP-EERRFPQLKVLSVANMLGEAIWRIHEESSVSSMFR 330
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 1-277 2.24e-44

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 152.97  E-value: 2.24e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRK-RGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:PRK02458  74 WELLIMIDACKRASANTVNVVLPYFGYARQDRIAKpREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPVDNLFT 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666  80 SPFLLQYIQEEIPDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIHGEAQDAESDlvDGrhsppmvrsvaaihpsleipm 159
Cdd:PRK02458 154 VPLFAKHYCKKGLSGSDVVVVSPKNSGIKRARSLAEYLDAPIAIIDYAQDDSERE--EG--------------------- 210

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666 160 lipkekppiTVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIp 239
Cdd:PRK02458 211 ---------YIIGDVAGKKAILIDDILNTGKTFAEAAKIVEREGATEIYAVASHGLFAGGAAEVLENAPIKEILVTDSV- 280

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 672067666 240 heIQKLQCPK-IKTVDISMILSEAIRRIHNGESMSYLFR 277
Cdd:PRK02458 281 --ATKERVPKnVTYLSASELIADAIIRIHERKPLSPLFA 317
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 1-276 3.09e-42

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 150.02  E-value: 3.09e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFN--IPVDNL 77
Cdd:PTZ00145 184 IELLLMISTCRRASAKKITAVIPYYGYARQdRKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQIQGFFGprVPVDNL 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666  78 RASPFLLQYIQEEipDYRNAVIVAKSPASAKRAQSFAERLrlgiavIHGEAQDAEsdlvdgrhsppmvrsvaaihpsleI 157
Cdd:PTZ00145 264 EAQLIGLDYFTKK--DLYKPVIVSPDAGGVYRARKFQDGL------NHRGISDCG------------------------I 311

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666 158 PMLI-----PKEKPPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEV 232
Cdd:PTZ00145 312 AMLIkqrtkPNEIEKMDLVGNVYDSDVIIVDDMIDTSGTLCEAAKQLKKHGARRVFAFATHGLFSGPAIERIEASPLEEV 391

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 672067666 233 VVTNTIPHEIQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLF 276
Cdd:PTZ00145 392 VVTDTVKSNKNIDSCKKITKLSVSVLVADAIRRIHQKESLNDLF 435
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 1-276 1.82e-40

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 143.13  E-value: 1.82e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQ-CKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:PRK00553  74 MELLIAIDALKRGSAKSITAILPYYGYARQdRKTAGREPITSKLVADLLTKAGVTRVTLTDIHSDQTQGFFDIPVDILRT 153

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666  80 SPFLLQYIQEEIpDYRNAVIVAKSPASAKRAQSFAERLRLGIAVIhgeaqdaesdlvDGRHSPPMVRSvaaihpsleipm 159
Cdd:PRK00553 154 YHVFLSRVLELL-GKKDLVVVSPDYGGVKRARLIAESLELPLAII------------DKRRPKHNVAE------------ 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666 160 lipkekpPITVVGDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEES----AIDEVVVT 235
Cdd:PRK00553 209 -------SINVLGEVKNKNCLIVDDMIDTGGTVIAAAKLLKKQKAKKVCVMATHGLFNKNAIQLFDEAfkkkLIDKLFVS 281

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 672067666 236 NTIPHEIQKlQCPKIKTVDISMILSEAIRRIHNGESMSYLF 276
Cdd:PRK00553 282 NSIPQTKFE-KKPQFKVVDLAHLYEEVLLCYANGGSISAIY 321
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 1-245 6.64e-25

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 100.37  E-value: 6.64e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666   1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRG-SIVSKLLASMMcKAGLTHLITMDLHQKEIQGFFNIPVDNLRA 79
Cdd:PRK00934  63 VELLLLIDALRDEGAKSITLVIPYLGYARQDKRFKPGePISARAIAKII-SAYYDRIITINIHEPSILEFFPIPFINLDA 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666  80 SPFLLQYIQEeipDYRNAVIVAKSPASAKRAQSFAERLrlGIAVIHGEAQdaesdlvdgRHSPPMVRsvaaIHPSlEIpm 159
Cdd:PRK00934 142 APLIAEYIGD---KLDDPLVLAPDKGALELAKEAAEIL--GCEYDYLEKT---------RISPTEVE----IAPK-NL-- 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666 160 lipkekppitvvgDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVVVTNTIP 239
Cdd:PRK00934 201 -------------DVKGKDVLIVDDIISTGGTMATAIKILKEQGAKKVYVACVHPVLVGDAILKLYNAGVDEIIVTDTLE 267


                 ....*.
gi 672067666 240 HEIQKL 245
Cdd:PRK00934 268 SEVSKI 273
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 1-52 1.42e-20

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 84.39  E-value: 1.42e-20
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 672067666    1 MELLIMVYACKTSCAKSIIGVIPYFPYSKQCKM-RKRGSIVSKLLASMMCKAG 52
Cdd:pfam13793  65 MELLIMIDALKRASAKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 15-278 2.25e-18

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 83.85  E-value: 2.25e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666  15 AKSIIGVIPYFPYSKQCKMRKRGSIVSKLLASMMCKAGLTHLITMDLHQKEIQGFFNIP-VDNLRASPFLLQYIQEEIPD 93
Cdd:PRK06827 122 ARRITVIMPFLYESRQHKRKGRESLDCALALQELEELGVDNIITFDAHDPRIENAIPLMgFENLYPSYQIIKALLKNEKD 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666  94 YR----NAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaQDaESDLVDGRHsppmvrsvaaihpsleipmlipkekpPIT 169
Cdd:PRK06827 202 LEidkdHLMVISPDTGAMDRAKYYASVLGVDLGLFYKR-RD-YSRVVNGRN--------------------------PIV 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666 170 VV----GDVGGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLsSDAPRLI----EESAIDEVVVTNTIPHE 241
Cdd:PRK06827 254 AHeflgRDVEGKDVLIVDDMIASGGSMIDAAKELKSRGAKKIIVAATFGFF-TNGLEKFdkayEEGYFDRIIGTNLVYHP 332

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 672067666 242 IQKLQCPKIKTVDISMILSEAIRRIHNGESMSYLFRN 278
Cdd:PRK06827 333 EELLSKPWYIEVDMSKLIARIIDALNHDVSLSKLLDP 369
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
2-265 3.61e-07

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 50.32  E-value: 3.61e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666   2 ELLIMVYACKTSCAKSIIGVIPYFPYSKQCKMRKRGSIVS-----KLLAsmmckAGLTHLITMD--LHQ-KEIQGFFNIP 73
Cdd:PRK07199  67 PLLFAAEAARELGARRVGLVAPYLAYMRQDIAFHPGEAISqrhfaRLLS-----GSFDRLVTVDphLHRyPSLSEVYPIP 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666  74 VDNLRASPFLLQYIQEEIPDyrnAVIVAKSPASAKRAQSFAERLRLGIAVIHGEaqdaesdlvdgRHSPpmvRSVaaihp 153
Cdd:PRK07199 142 AVVLSAAPAIAAWIRAHVPR---PLLIGPDEESEQWVAAVAERAGAPHAVLRKT-----------RHGD---RDV----- 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672067666 154 slEIPMlipkekPPITVVGdvgGRIAIIVDDIIDDVDSFLAAAETLKERGAYKIFVMATHGLLSSDAPRLIEESAIDEVV 233
Cdd:PRK07199 200 --EISL------PDAAPWA---GRTPVLVDDIVSTGRTLIEAARQLRAAGAASPDCVVVHALFAGDAYSALAAAGIARVV 268

                        250       260       270
                 ....*....|....*....|....*....|..
gi 672067666 234 VTNTIPHEIQklqcpkikTVDISMILSEAIRR 265
Cdd:PRK07199 269 STDTVPHPSN--------AISLAPLLAEALRR 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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