NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|672062885|ref|XP_008764721|]
View 

protein ABHD14A isoform X1 [Rattus norvegicus]

Protein Classification

alpha/beta fold hydrolase( domain architecture ID 11426811)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

PubMed:  1409539|12369917

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 68-197 5.83e-15

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


:

Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 70.42  E-value: 5.83e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672062885  68 VVFLHGKAFNSHTWEQLgtLQLLSKRgYRAVAVDLPGFGNSAPSKEVSTESGRVELLEGVLRDLQLQNTVL--------- 138
Cdd:COG0596   26 VVLLHGLPGSSYEWRPL--IPALAAG-YRVIAPDLRGHGRSDKPAGGYTLDDLADDLAALLDALGLERVVLvghsmggmv 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672062885 139 -----------------------------------------------------------TPTLILYGELDHTLARESLQQ 159
Cdd:COG0596  103 alelaarhpervaglvlvdevlaalaeplrrpglapealaallralartdlrerlaritVPTLVIWGEKDPIVPPALARR 182

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 672062885 160 L-RHLPNHSVVKLHNAGHACYLHKPEAFHLALLAFLDHL 197
Cdd:COG0596  183 LaELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 68-197 5.83e-15

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 70.42  E-value: 5.83e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672062885  68 VVFLHGKAFNSHTWEQLgtLQLLSKRgYRAVAVDLPGFGNSAPSKEVSTESGRVELLEGVLRDLQLQNTVL--------- 138
Cdd:COG0596   26 VVLLHGLPGSSYEWRPL--IPALAAG-YRVIAPDLRGHGRSDKPAGGYTLDDLADDLAALLDALGLERVVLvghsmggmv 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672062885 139 -----------------------------------------------------------TPTLILYGELDHTLARESLQQ 159
Cdd:COG0596  103 alelaarhpervaglvlvdevlaalaeplrrpglapealaallralartdlrerlaritVPTLVIWGEKDPIVPPALARR 182

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 672062885 160 L-RHLPNHSVVKLHNAGHACYLHKPEAFHLALLAFLDHL 197
Cdd:COG0596  183 LaELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
80-193 8.29e-05

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 41.93  E-value: 8.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672062885  80 TWEQLGTLQLLSKRGYRAVAVDLPGFGNSAPSKEVSTESGRVELLEGVLRDLQLQNtVLTPTLILYGELDHTLARESLQQ 159
Cdd:PRK10349 139 TVERFLALQTMGTETARQDARALKKTVLALPMPEVDVLNGGLEILKTVDLRQPLQN-VSMPFLRLYGYLDGLVPRKVVPM 217

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 672062885 160 LRHLPNHSVVKLH-NAGHACYLHKPEAFHLALLAF 193
Cdd:PRK10349 218 LDKLWPHSESYIFaKAAHAPFISHPAEFCHLLVAL 252
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 68-113 5.83e-04

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 39.41  E-value: 5.83e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 672062885   68 VVFLHGKAFNSHTWEQLgtLQLLSKRGYRAVAVDLPGFGNSAPSKE 113
Cdd:pfam00561   3 VLLLHGLPGSSDLWRKL--APALARDGFRVIALDLRGFGKSSRPKA 46
 
Name Accession Description Interval E-value
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 68-197 5.83e-15

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 70.42  E-value: 5.83e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672062885  68 VVFLHGKAFNSHTWEQLgtLQLLSKRgYRAVAVDLPGFGNSAPSKEVSTESGRVELLEGVLRDLQLQNTVL--------- 138
Cdd:COG0596   26 VVLLHGLPGSSYEWRPL--IPALAAG-YRVIAPDLRGHGRSDKPAGGYTLDDLADDLAALLDALGLERVVLvghsmggmv 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672062885 139 -----------------------------------------------------------TPTLILYGELDHTLARESLQQ 159
Cdd:COG0596  103 alelaarhpervaglvlvdevlaalaeplrrpglapealaallralartdlrerlaritVPTLVIWGEKDPIVPPALARR 182

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 672062885 160 L-RHLPNHSVVKLHNAGHACYLHKPEAFHLALLAFLDHL 197
Cdd:COG0596  183 LaELLPNAELVVLPGAGHFPPLEQPEAFAAALRDFLARL 221
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
46-195 1.08e-06

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 47.30  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672062885  46 TRGSSQIFYREVLPLQQTHRAeVVFLHGkaFNSHTWEQLGTLQLLSKRGYRAVAVDLPGFGNSAPS-------------- 111
Cdd:COG2267   10 TRDGLRLRGRRWRPAGSPRGT-VVLVHG--LGEHSGRYAELAEALAAAGYAVLAFDLRGHGRSDGPrghvdsfddyvddl 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672062885 112 ----KEVSTESGR----------------------------------------VELLEGVLRDLQLQN---TVLTPTLIL 144
Cdd:COG2267   87 raalDALRARPGLpvvllghsmggliallyaarypdrvaglvllapayradplLGPSARWLRALRLAEalaRIDVPVLVL 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 672062885 145 YGELDHTLARESLQQL--RHLPNHSVVKLHNAGHACYLHKP-EAFHLALLAFLD 195
Cdd:COG2267  167 HGGADRVVPPEAARRLaaRLSPDVELVLLPGARHELLNEPArEEVLAAILAWLE 220
PRK10349 PRK10349
pimeloyl-ACP methyl ester esterase BioH;
80-193 8.29e-05

pimeloyl-ACP methyl ester esterase BioH;


Pssm-ID: 137836 [Multi-domain]  Cd Length: 256  Bit Score: 41.93  E-value: 8.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672062885  80 TWEQLGTLQLLSKRGYRAVAVDLPGFGNSAPSKEVSTESGRVELLEGVLRDLQLQNtVLTPTLILYGELDHTLARESLQQ 159
Cdd:PRK10349 139 TVERFLALQTMGTETARQDARALKKTVLALPMPEVDVLNGGLEILKTVDLRQPLQN-VSMPFLRLYGYLDGLVPRKVVPM 217

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 672062885 160 LRHLPNHSVVKLH-NAGHACYLHKPEAFHLALLAF 193
Cdd:PRK10349 218 LDKLWPHSESYIFaKAAHAPFISHPAEFCHLLVAL 252
PRK00870 PRK00870
haloalkane dehalogenase; Provisional
 68-138 2.42e-04

haloalkane dehalogenase; Provisional


Pssm-ID: 179147 [Multi-domain]  Cd Length: 302  Bit Score: 40.72  E-value: 2.42e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672062885  68 VVFLHGKAfnshTWEQL--GTLQLLSKRGYRAVAVDLPGFGNS-APSK-EVSTESGRVELLEGVLRDLQLQNTVL 138
Cdd:PRK00870  49 VLLLHGEP----SWSYLyrKMIPILAAAGHRVIAPDLIGFGRSdKPTRrEDYTYARHVEWMRSWFEQLDLTDVTL 119
Abhydrolase_1 pfam00561
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 68-113 5.83e-04

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 395444 [Multi-domain]  Cd Length: 245  Bit Score: 39.41  E-value: 5.83e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 672062885   68 VVFLHGKAFNSHTWEQLgtLQLLSKRGYRAVAVDLPGFGNSAPSKE 113
Cdd:pfam00561   3 VLLLHGLPGSSDLWRKL--APALARDGFRVIALDLRGFGKSSRPKA 46
PLN03087 PLN03087
BODYGUARD 1 domain containing hydrolase; Provisional
 45-125 3.25e-03

BODYGUARD 1 domain containing hydrolase; Provisional


Pssm-ID: 215567  Cd Length: 481  Bit Score: 37.48  E-value: 3.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672062885  45 LTRGSSQIFYREVLPLQQTHRAEVVFLHGKAFNSHTWEQ--LGTLQLLSKRGYRAVAVDLPGFGNS-APSKEVSTESGRV 121
Cdd:PLN03087 181 LSSSNESLFVHVQQPKDNKAKEDVLFIHGFISSSAFWTEtlFPNFSDAAKSTYRLFAVDLLGFGRSpKPADSLYTLREHL 260


                 ....
gi 672062885 122 ELLE 125
Cdd:PLN03087 261 EMIE 264
Abhydrolase_6 pfam12697
Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse ...
 68-138 4.39e-03

Alpha/beta hydrolase family; This family contains alpha/beta hydrolase enzymes of diverse specificity.


Pssm-ID: 463673 [Multi-domain]  Cd Length: 211  Bit Score: 36.68  E-value: 4.39e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672062885   68 VVFLHGkafnshTWEQLGTLQLLSKRGYRAVAVDLPGFGNSAPSkevSTESGRVELLEGVLRDLQLQNTVL 138
Cdd:pfam12697   1 VVLVHG------AGLSAAPLAALLAAGVAVLAPDLPGHGSSSPP---PLDLADLADLAALLDELGAARPVV 62
YheT COG0429
Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];
35-132 7.12e-03

Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only];


Pssm-ID: 440198 [Multi-domain]  Cd Length: 323  Bit Score: 36.27  E-value: 7.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672062885  35 RGPNV-TVLTGLTRGSSQIFY-REVLPL-------------QQTHRAEVVFLHGKAFNSHTWEQLGTLQLLSKRGYRAVA 99
Cdd:COG0429   16 RNGHLqTIYPSLFRRRPALPYrRERLELpdgdfvdldwsdpPAPSKPLVVLLHGLEGSSDSHYARGLARALYARGWDVVR 95

                         90       100       110
                 ....*....|....*....|....*....|...
gi 672062885 100 VDLPGFGNSAPSKEVSTESGRVELLEGVLRDLQ 132
Cdd:COG0429   96 LNFRGCGGEPNLLPRLYHSGDTEDLVWVLAHLR 128
Hydrolase_4 pfam12146
Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is ...
 64-133 7.78e-03

Serine aminopeptidase, S33; This domain is found in bacteria and eukaryotes and is approximately 110 amino acids in length. It is found in association with pfam00561. The majority of the members in this family carry the exopeptidase active-site residues of Ser-122, Asp-239 and His-269 as in UniProtKB:Q7ZWC2.


Pssm-ID: 463473 [Multi-domain]  Cd Length: 238  Bit Score: 36.04  E-value: 7.78e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672062885   64 HRAEVVFLHGkaFNSHTW--EQLGtlQLLSKRGYRAVAVDLPGFGNSAPskevstESGRVELLEGVLRDLQL 133
Cdd:pfam12146   3 PRAVVVLVHG--LGEHSGryAHLA--DALAAQGFAVYAYDHRGHGRSDG------KRGHVPSFDDYVDDLDT 64
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
122-198 8.21e-03

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 36.07  E-value: 8.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672062885 122 ELLEGVLRDLqlqNTVLTPTLILYGELDHTLARESLQQL-RHL--PNHSVVKLHNAGH-ACYLHKPEAFHLALLAFLDHL 197
Cdd:COG1647  168 RLIREVRRDL---PKITAPTLIIQSRKDEVVPPESARYIyERLgsPDKELVWLEDSGHvITLDKDREEVAEEILDFLERL 244


                 .
gi 672062885 198 P 198
Cdd:COG1647  245 A 245
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 68-108 8.25e-03

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 34.81  E-value: 8.25e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 672062885  68 VVFLHGKAFNSHTWEQLGtlQLLSKRGYRAVAVDLPGFGNS 108
Cdd:COG1075    8 VVLVHGLGGSAASWAPLA--PRLRAAGYPVYALNYPSTNGS 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH