NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|672058435|ref|XP_008763518|]
View 

glycosyltransferase 8 domain-containing protein 2 isoform X1 [Rattus norvegicus]

Protein Classification

glycosyltransferase family protein( domain architecture ID 27718)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Glyco_tranf_GTA_type super family cl11394
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
 69-293 9.23e-58

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


The actual alignment was detected with superfamily member cd06429:

Pssm-ID: 472172 [Multi-domain]  Cd Length: 257  Bit Score: 187.98  E-value: 9.23e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435  69 INSIYSNTD-ANIVFYVVGLRNTLSRIRQWIEHSKLKEINFKIVEFNPIVLKGKIRPDS---------------SRPELL 132
Cdd:cd06429   18 NSSISNNKDpSNLVFHIVTDNQNYGAMRSWFDLNPLKIATVKVLNFDDFKLLGKVKVDSlmqleseadtsnlkqRKPEYI 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 133 QPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDdcdlpsaqdihrlvglqntymgyldyrkk 212
Cdd:cd06429   98 SLLNFARFYLPELFPKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGAVET----------------------------- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 213 sikelgispstcSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEEnlySSSLGGGVATSPMLIVFHGKYSTINPLWHIRH 292
Cdd:cd06429  149 ------------SWNPGVNVVNLTEWRRQNVTETYEKWMELNQEE---EVTLWKLITLPPGLIVFYGLTSPLDPSWHVRG 213


                 .
gi 672058435 293 L 293
Cdd:cd06429  214 L 214
 
Name Accession Description Interval E-value
GT8_like_1 cd06429
GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of ...
 69-293 9.23e-58

GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of glycosyltransferase family 8 with unknown function: Glycosyltransferase family 8 comprises enzymes with a number of known activities; lipopolysaccharide galactosyltransferase lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase and inositol 1-alpha-galactosyltransferase. It is classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed.


Pssm-ID: 133051 [Multi-domain]  Cd Length: 257  Bit Score: 187.98  E-value: 9.23e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435  69 INSIYSNTD-ANIVFYVVGLRNTLSRIRQWIEHSKLKEINFKIVEFNPIVLKGKIRPDS---------------SRPELL 132
Cdd:cd06429   18 NSSISNNKDpSNLVFHIVTDNQNYGAMRSWFDLNPLKIATVKVLNFDDFKLLGKVKVDSlmqleseadtsnlkqRKPEYI 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 133 QPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDdcdlpsaqdihrlvglqntymgyldyrkk 212
Cdd:cd06429   98 SLLNFARFYLPELFPKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGAVET----------------------------- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 213 sikelgispstcSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEEnlySSSLGGGVATSPMLIVFHGKYSTINPLWHIRH 292
Cdd:cd06429  149 ------------SWNPGVNVVNLTEWRRQNVTETYEKWMELNQEE---EVTLWKLITLPPGLIVFYGLTSPLDPSWHVRG 213


                 .
gi 672058435 293 L 293
Cdd:cd06429  214 L 214
Glyco_transf_8 pfam01501
Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to ...
 69-295 3.56e-33

Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase.


Pssm-ID: 279798 [Multi-domain]  Cd Length: 252  Bit Score: 123.59  E-value: 3.56e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435   69 INSIYSNT-DANIVFYVVGLRNTLSRIRQWIEHSKLKEINFKIVEFNPIVLKGKIRPDSSRPELLQPLNFVRFYLPLLVH 147
Cdd:pfam01501  18 IKSLLKNNsDFALNFHIFTDDIPVENLDILNWLASSYKPVLPLLESDIKIFEYFSKLKLRSPKYWSLLNYLRLYLPDLFP 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435  148 QHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDcdlpsaqdihrlvglqnTYMGYLDYRKKSIKELGISPSTCSFN 227
Cdd:pfam01501  98 KLDKILYLDADIVVQGDLSPLWDIDLG-GKVLAAVED-----------------NYFQRYPNFSEPIILENFGPPACYFN 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672058435  228 PGVIVANMTEWKHQRITKQLEKWMqkNVEENLYSSSLGggvATSPMLIVFHGKYSTINPLWHIRHLVS 295
Cdd:pfam01501 160 AGMLLFDLDAWRKENITERYIKWL--NLNENRTLWKLG---DQDPLNIVFYGKVKPLDPRWNVLGLGY 222
PLN02659 PLN02659
Probable galacturonosyltransferase
 114-290 8.88e-18

Probable galacturonosyltransferase


Pssm-ID: 215356 [Multi-domain]  Cd Length: 534  Bit Score: 84.31  E-value: 8.88e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 114 NPIVLKGKIRPDSsrPELLQPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCdlpSAQDi 193
Cdd:PLN02659 311 KPHVIAAKLQALS--PKYNSVMNHIRIHLPELFPSLNKVVFLDDDIVVQTDLSPLWDIDMN-GKVNGAVETC---RGED- 383

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 194 hRLVgLQNTYMGYLDYRKKSIKElGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYSSSLGggvATSPM 273
Cdd:PLN02659 384 -KFV-MSKKLKSYLNFSHPLIAK-NFDPNECAWAYGMNIFDLEAWRKTNISSTYHHWLEENLKSDLSLWQLG---TLPPG 457

                        170
                 ....*....|....*..
gi 672058435 274 LIVFHGKYSTINPLWHI 290
Cdd:PLN02659 458 LIAFHGHVHVIDPFWHM 474
RfaJ COG1442
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ...
 71-260 1.68e-17

Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441051 [Multi-domain]  Cd Length: 301  Bit Score: 81.56  E-value: 1.68e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435  71 SIYS----NTDANIVFYVV--GLRN-TLSRIRQWIE--HSKLKEINFKIVEFNPIVLKGKIRPDSsrpellqplnFVRFY 141
Cdd:COG1442   23 SIASllenNPDRPYDFHILtdGLSDeNKERLEALAAkyNVSIEFIDVDDELLKDLPVSKHISKAT----------YYRLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 142 LP-LLVHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCDLPSaqdihrlvglqntymgyldYRKKSIKELGIS 220
Cdd:COG1442   93 IPeLLPDDYDKVLYLDADTLVLGDLSELWDIDLG-GNLLAAVRDGTVTG-------------------SQKKRAKRLGLP 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 672058435 221 PSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLY 260
Cdd:COG1442  153 DDDGYFNSGVLLINLKKWREENITEKALEFLKENPDKLKY 192
 
Name Accession Description Interval E-value
GT8_like_1 cd06429
GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of ...
 69-293 9.23e-58

GT8_like_1 represents a subfamily of GT8 with unknown function; A subfamily of glycosyltransferase family 8 with unknown function: Glycosyltransferase family 8 comprises enzymes with a number of known activities; lipopolysaccharide galactosyltransferase lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase and inositol 1-alpha-galactosyltransferase. It is classified as a retaining glycosyltransferase, based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed.


Pssm-ID: 133051 [Multi-domain]  Cd Length: 257  Bit Score: 187.98  E-value: 9.23e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435  69 INSIYSNTD-ANIVFYVVGLRNTLSRIRQWIEHSKLKEINFKIVEFNPIVLKGKIRPDS---------------SRPELL 132
Cdd:cd06429   18 NSSISNNKDpSNLVFHIVTDNQNYGAMRSWFDLNPLKIATVKVLNFDDFKLLGKVKVDSlmqleseadtsnlkqRKPEYI 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 133 QPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDdcdlpsaqdihrlvglqntymgyldyrkk 212
Cdd:cd06429   98 SLLNFARFYLPELFPKLEKVIYLDDDVVVQKDLTELWNTDLGGGVAGAVET----------------------------- 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 213 sikelgispstcSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEEnlySSSLGGGVATSPMLIVFHGKYSTINPLWHIRH 292
Cdd:cd06429  149 ------------SWNPGVNVVNLTEWRRQNVTETYEKWMELNQEE---EVTLWKLITLPPGLIVFYGLTSPLDPSWHVRG 213


                 .
gi 672058435 293 L 293
Cdd:cd06429  214 L 214
Glyco_transf_8 pfam01501
Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to ...
 69-295 3.56e-33

Glycosyl transferase family 8; This family includes enzymes that transfer sugar residues to donor molecules. Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. This family includes Lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, and glycogenin glucosyltransferase.


Pssm-ID: 279798 [Multi-domain]  Cd Length: 252  Bit Score: 123.59  E-value: 3.56e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435   69 INSIYSNT-DANIVFYVVGLRNTLSRIRQWIEHSKLKEINFKIVEFNPIVLKGKIRPDSSRPELLQPLNFVRFYLPLLVH 147
Cdd:pfam01501  18 IKSLLKNNsDFALNFHIFTDDIPVENLDILNWLASSYKPVLPLLESDIKIFEYFSKLKLRSPKYWSLLNYLRLYLPDLFP 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435  148 QHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDcdlpsaqdihrlvglqnTYMGYLDYRKKSIKELGISPSTCSFN 227
Cdd:pfam01501  98 KLDKILYLDADIVVQGDLSPLWDIDLG-GKVLAAVED-----------------NYFQRYPNFSEPIILENFGPPACYFN 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672058435  228 PGVIVANMTEWKHQRITKQLEKWMqkNVEENLYSSSLGggvATSPMLIVFHGKYSTINPLWHIRHLVS 295
Cdd:pfam01501 160 AGMLLFDLDAWRKENITERYIKWL--NLNENRTLWKLG---DQDPLNIVFYGKVKPLDPRWNVLGLGY 222
Glyco_transf_8 cd00505
Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis ...
 70-293 1.08e-25

Members of glycosyltransferase family 8 (GT-8) are involved in lipopolysaccharide biosynthesis and glycogen synthesis; Members of this family are involved in lipopolysaccharide biosynthesis and glycogen synthesis. GT-8 comprises enzymes with a number of known activities: lipopolysaccharide galactosyltransferase, lipopolysaccharide glucosyltransferase 1, glycogenin glucosyltransferase, and N-acetylglucosaminyltransferase. GT-8 enzymes contains a conserved DXD motif which is essential in the coordination of a catalytic divalent cation, most commonly Mn2+.


Pssm-ID: 132996 [Multi-domain]  Cd Length: 246  Bit Score: 103.29  E-value: 1.08e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435  70 NSIYSNTDANIVFYVvgLRNTLSR-IRQWIEHSkLKEINFkIVEFNPIVLKGKIRPDS-SRPELlqPLNFVRFYLPLLVH 147
Cdd:cd00505   21 KSVLRHRTKPLRFHV--LTNPLSDtFKAALDNL-RKLYNF-NYELIPVDILDSVDSEHlKRPIK--IVTLTKLHLPNLVP 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 148 QHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDDCDlpsaqdihrlvglqnTYMGYLDYRKKSIKELgispsTCSFN 227
Cdd:cd00505   95 DYDKILYVDADILVLTDIDELWDTPLGGQELAAAPDPGD---------------RREGKYYRQKRSHLAG-----PDYFN 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672058435 228 PGVIVANMTEW-KHQRITKQLEKWMQKNVEENLYSSSLGGGVATSPMLIVFHgkystINPLWHIRHL 293
Cdd:cd00505  155 SGVFVVNLSKErRNQLLKVALEKWLQSLSSLSGGDQDLLNTFFKQVPFIVKS-----LPCIWNVRLT 216
PLN02659 PLN02659
Probable galacturonosyltransferase
 114-290 8.88e-18

Probable galacturonosyltransferase


Pssm-ID: 215356 [Multi-domain]  Cd Length: 534  Bit Score: 84.31  E-value: 8.88e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 114 NPIVLKGKIRPDSsrPELLQPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCdlpSAQDi 193
Cdd:PLN02659 311 KPHVIAAKLQALS--PKYNSVMNHIRIHLPELFPSLNKVVFLDDDIVVQTDLSPLWDIDMN-GKVNGAVETC---RGED- 383

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 194 hRLVgLQNTYMGYLDYRKKSIKElGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYSSSLGggvATSPM 273
Cdd:PLN02659 384 -KFV-MSKKLKSYLNFSHPLIAK-NFDPNECAWAYGMNIFDLEAWRKTNISSTYHHWLEENLKSDLSLWQLG---TLPPG 457

                        170
                 ....*....|....*..
gi 672058435 274 LIVFHGKYSTINPLWHI 290
Cdd:PLN02659 458 LIAFHGHVHVIDPFWHM 474
RfaJ COG1442
Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope ...
 71-260 1.68e-17

Lipopolysaccharide biosynthesis protein, LPS:glycosyltransferase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441051 [Multi-domain]  Cd Length: 301  Bit Score: 81.56  E-value: 1.68e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435  71 SIYS----NTDANIVFYVV--GLRN-TLSRIRQWIE--HSKLKEINFKIVEFNPIVLKGKIRPDSsrpellqplnFVRFY 141
Cdd:COG1442   23 SIASllenNPDRPYDFHILtdGLSDeNKERLEALAAkyNVSIEFIDVDDELLKDLPVSKHISKAT----------YYRLL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 142 LP-LLVHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCDLPSaqdihrlvglqntymgyldYRKKSIKELGIS 220
Cdd:COG1442   93 IPeLLPDDYDKVLYLDADTLVLGDLSELWDIDLG-GNLLAAVRDGTVTG-------------------SQKKRAKRLGLP 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 672058435 221 PSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLY 260
Cdd:COG1442  153 DDDGYFNSGVLLINLKKWREENITEKALEFLKENPDKLKY 192
PLN02742 PLN02742
Probable galacturonosyltransferase
 69-290 2.01e-16

Probable galacturonosyltransferase


Pssm-ID: 215395 [Multi-domain]  Cd Length: 534  Bit Score: 80.20  E-value: 2.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435  69 INSIYSNTDA--NIVFYVVGLRNTLSRIRQW----------IEHSKLKEINFKIVEFNPiVLK----------------- 119
Cdd:PLN02742 244 VNSTVSNAKHpdQLVFHLVTDEVNYGAMQAWfamndfkgvtVEVQKIEEFSWLNASYVP-VLKqlqdsdtqsyyfsgsqd 322

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 120 -GKIRPDSSRPELLQPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCdlpsAQDIHRlvg 198
Cdd:PLN02742 323 dGKTEIKFRNPKYLSMLNHLRFYIPEIYPALEKVVFLDDDVVVQKDLTPLFSIDLH-GNVNGAVETC----LETFHR--- 394

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 199 lqntYMGYLDYRKKSIKElGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssSLGggvATSPMLIVFH 278
Cdd:PLN02742 395 ----YHKYLNFSHPLISS-HFDPDACGWAFGMNVFDLVAWRKANVTAIYHYWQEQNVDRTLW--KLG---TLPPGLLTFY 464

                        250
                 ....*....|..
gi 672058435 279 GKYSTINPLWHI 290
Cdd:PLN02742 465 GLTEPLDRRWHV 476
PLN02870 PLN02870
Probable galacturonosyltransferase
 112-290 1.05e-15

Probable galacturonosyltransferase


Pssm-ID: 215468 [Multi-domain]  Cd Length: 533  Bit Score: 78.06  E-value: 1.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 112 EFNPIVLKGKIRPDSsrPELLQPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCdlpSAQ 191
Cdd:PLN02870 308 ETTPRTFASKLQARS--PKYISLLNHLRIYLPELFPNLDKVVFLDDDVVIQRDLSPLWDIDLG-GKVNGAVETC---RGE 381

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 192 DIHRlvgLQNTYMGYLDYRKKSIKElGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYSSSLGggvATS 271
Cdd:PLN02870 382 DEWV---MSKRFRNYFNFSHPLIAK-NLDPEECAWAYGMNIFDLRAWRKTNIRETYHSWLKENLKSNLTMWKLG---TLP 454

                        170
                 ....*....|....*....
gi 672058435 272 PMLIVFHGKYSTINPLWHI 290
Cdd:PLN02870 455 PALIAFKGHVHPIDPSWHM 473
GT8_A4GalT_like cd04194
A4GalT_like proteins catalyze the addition of galactose or glucose residues to the ...
 69-260 6.04e-14

A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; The members of this family of glycosyltransferases catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface. The enzymes exhibit broad substrate specificities. The known functions found in this family include: Alpha-1,4-galactosyltransferase, LOS-alpha-1,3-D-galactosyltransferase, UDP-glucose:(galactosyl) LPS alpha1,2-glucosyltransferase, UDP-galactose: (glucosyl) LPS alpha1,2-galactosyltransferase, and UDP-glucose:(glucosyl) LPS alpha1,2-glucosyltransferase. Alpha-1,4-galactosyltransferase from N. meningitidis adds an alpha-galactose from UDP-Gal (the donor) to a terminal lactose (the acceptor) of the LOS structure of outer membrane. LOSs are virulence factors that enable the organism to evade the immune system of host cells. In E. coli, the three alpha-1,2-glycosyltransferases, that are involved in the synthesis of the outer core region of the LPS, are all members of this family. The three enzymes share 40 % of sequence identity, but have different sugar donor or acceptor specificities, representing the structural diversity of LPS.


Pssm-ID: 133037 [Multi-domain]  Cd Length: 248  Bit Score: 70.71  E-value: 6.04e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435  69 INSIYSNTDA-NIVFYVVglrntlsrirqwieHSKLKEINFKIvefnpivLKGKIRPDSSR-------PELLQPLNFV-- 138
Cdd:cd04194   19 IKSILANNSKrDYDFYIL--------------NDDISEENKKK-------LKELLKKYNSSiefikidNDDFKFFPATtd 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 139 --------RFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCdlpsaqdihrlvglqntymgYLDYR 210
Cdd:cd04194   78 hisyatyyRLLIPDLLPDYDKVLYLDADIIVLGDLSELFDIDLG-DNLLAAVRDP--------------------FIEQE 136

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 672058435 211 KKSIKELGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLY 260
Cdd:cd04194  137 KKRKRRLGGYDDGSYFNSGVLLINLKKWREENITEKLLELIKEYGGRLIY 186
PLN02910 PLN02910
polygalacturonate 4-alpha-galacturonosyltransferase
 92-290 3.60e-13

polygalacturonate 4-alpha-galacturonosyltransferase


Pssm-ID: 215493 [Multi-domain]  Cd Length: 657  Bit Score: 70.36  E-value: 3.60e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435  92 SRIRQwIEHSKLKEINFKIVEFNPIVlKGKIRPDSSRPELLQPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDT 171
Cdd:PLN02910 420 SVLRQ-LESARIKEYYFKANHPSSLS-AGADNLKYRNPKYLSMLNHLRFYLPEVYPKLEKILFLDDDIVVQKDLTPLWSI 497

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 172 TLAlGHAAAFSDDCDlpsaQDIHRlvglqntYMGYLDYRKKSIKElGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWM 251
Cdd:PLN02910 498 DMQ-GMVNGAVETCK----ESFHR-------FDKYLNFSNPKISE-NFDPNACGWAFGMNMFDLKEWRKRNITGIYHYWQ 564

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 672058435 252 QKNVEENLYssSLGggvATSPMLIVFHGKYSTINPLWHI 290
Cdd:PLN02910 565 DLNEDRTLW--KLG---SLPPGLITFYNLTYPLDRSWHV 598
PLN02523 PLN02523
galacturonosyltransferase
 129-290 5.71e-13

galacturonosyltransferase


Pssm-ID: 215286 [Multi-domain]  Cd Length: 559  Bit Score: 69.90  E-value: 5.71e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 129 PELLQPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCdlpsAQDIHRlvglqntYMGYLD 208
Cdd:PLN02523 357 PKYLSMLNHLRFYLPEMYPKLHRILFLDDDVVVQKDLTGLWKIDMD-GKVNGAVETC----FGSFHR-------YAQYLN 424

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 209 YRKKSIKElGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssSLGggvATSPMLIVFhgkYSTINPL- 287
Cdd:PLN02523 425 FSHPLIKE-KFNPKACAWAYGMNIFDLDAWRREKCTEQYHYWQNLNENRTLW--KLG---TLPPGLITF---YSTTKPLd 495


                 ....*
gi 672058435 288 --WHI 290
Cdd:PLN02523 496 ksWHV 500
PLN02829 PLN02829
Probable galacturonosyltransferase
 129-290 2.41e-12

Probable galacturonosyltransferase


Pssm-ID: 215443 [Multi-domain]  Cd Length: 639  Bit Score: 67.95  E-value: 2.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 129 PELLQPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCdlpsAQDIHRlvglqntYMGYLD 208
Cdd:PLN02829 437 PKYLSILNHLRFYLPEIFPKLNKVLFLDDDIVVQKDLTGLWSIDLK-GNVNGAVETC----GESFHR-------FDRYLN 504

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 209 YRKKSIKElGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYssSLGggvATSPMLIVFHGKYSTINPLW 288
Cdd:PLN02829 505 FSNPLISK-NFDPHACGWAYGMNVFDLDEWKRQNITEVYHSWQKLNHDRQLW--KLG---TLPPGLITFWKRTYPLDRSW 578


                 ..
gi 672058435 289 HI 290
Cdd:PLN02829 579 HV 580
PLN02867 PLN02867
Probable galacturonosyltransferase
 129-293 3.34e-12

Probable galacturonosyltransferase


Pssm-ID: 178458 [Multi-domain]  Cd Length: 535  Bit Score: 67.23  E-value: 3.34e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 129 PELLQPLNFVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSD----DCDLPSAQdihrlvglqntYM 204
Cdd:PLN02867 325 PSCLSLLNHLRIYIPELFPDLNKIVFLDDDVVVQHDLSSLWELDLNGKVVGAVVDswcgDNCCPGRK-----------YK 393

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 205 GYLDYRKKSIKElGISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYSSSLGggvATSPMLIVFHGKYSTI 284
Cdd:PLN02867 394 DYLNFSHPLISS-NLDQERCAWLYGMNVFDLKAWRRTNITEAYHKWLKLSLNSGLQLWQPG---ALPPALLAFKGHVHPI 469


                 ....*....
gi 672058435 285 NPLWHIRHL 293
Cdd:PLN02867 470 DPSWHVAGL 478
PLN02718 PLN02718
Probable galacturonosyltransferase
 69-290 5.36e-09

Probable galacturonosyltransferase


Pssm-ID: 178320 [Multi-domain]  Cd Length: 603  Bit Score: 57.60  E-value: 5.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435  69 INSIYSNTD--ANIVFYVVGLRNTLSRIRQW----------IEHSKLKEINFKIVEFNPIVLKgkirPDSSRPELLQPLN 136
Cdd:PLN02718 330 VNSTISSSKepEKIVFHVVTDSLNYPAISMWfllnppgkatIQILNIDDMNVLPADYNSLLMK----QNSHDPRYISALN 405

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 137 FVRFYLPLLVHQHEKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDC--DLPSAQDIHRLVGLQNTYMGyldyrKKsi 214
Cdd:PLN02718 406 HARFYLPDIFPGLNKIVLFDHDVVVQRDLSRLWSLDMK-GKVVGAVETCleGEPSFRSMDTFINFSDPWVA-----KK-- 477

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 672058435 215 kelgISPSTCSFNPGVIVANMTEWKHQRITKQLEKWMQKNVEENLYSS-SLGGGVATspmlivFHGKYSTINPLWHI 290
Cdd:PLN02718 478 ----FDPKACTWAFGMNLFDLEEWRRQKLTSVYHKYLQLGVKRPLWKAgSLPIGWLT------FYNQTVALDKRWHV 544
PRK15171 PRK15171
lipopolysaccharide 3-alpha-galactosyltransferase;
146-246 1.54e-06

lipopolysaccharide 3-alpha-galactosyltransferase;


Pssm-ID: 185093 [Multi-domain]  Cd Length: 334  Bit Score: 49.36  E-value: 1.54e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 146 VHQHEKVIYLDDDVIVQGDIQELYDTTLALGHAAAFSDDCDLpsaqdihrlvglqntymGYLDYRKKSIKELGISPSTcs 225
Cdd:PRK15171 118 IDKTDKVLYLDADIACKGSIKELIDLDFAENEIAAVVAEGDA-----------------EWWSKRAQSLQTPGLASGY-- 178

                         90       100
                 ....*....|....*....|.
gi 672058435 226 FNPGVIVANMTEWKHQRITKQ 246
Cdd:PRK15171 179 FNSGFLLINIPAWAQENISAK 199
PLN02769 PLN02769
Probable galacturonosyltransferase
 140-264 3.84e-05

Probable galacturonosyltransferase


Pssm-ID: 215412 [Multi-domain]  Cd Length: 629  Bit Score: 45.46  E-value: 3.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672058435 140 FYLPLLVHQHEKVIYLDDDVIVQGDIQELYDttLALGH----AAAFsddCDLpsaqdihRLVGLQNtYMGYLDYRKKSik 215
Cdd:PLN02769 443 FLLPEIFKKLKKVVVLDDDVVVQRDLSFLWN--LDMGGkvngAVQF---CGV-------RLGQLKN-YLGDTNFDTNS-- 507

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 672058435 216 elgispstCSFNPGVIVANMTEWKHQRITK---QLEKWMQKNVEENLYSSSL 264
Cdd:PLN02769 508 --------CAWMSGLNVIDLDKWRELDVTEtylKLLQKFSKDGEESLRAAAL 551
GT8_HUGT1_C_like cd06432
The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family; C-terminal domain ...
 150-186 6.88e-03

The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family; C-terminal domain of glycoprotein glucosyltransferase (UGT). UGT is a large glycoprotein whose C-terminus contains the catalytic activity. This catalytic C-terminal domain is highly homologous to Glycosyltransferase Family 8 (GT 8) and contains the DXD motif that coordinates donor sugar binding, characteristic for Family 8 glycosyltransferases. GT 8 proteins are retaining enzymes based on the relative anomeric stereochemistry of the substrate and product in the reaction catalyzed. The non-catalytic N-terminal portion of the human UTG1 (HUGT1) has been shown to monitor the protein folding status and activate its glucosyltransferase activity.


Pssm-ID: 133054  Cd Length: 248  Bit Score: 37.75  E-value: 6.88e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 672058435 150 EKVIYLDDDVIVQGDIQELYDTTLAlGHAAAFSDDCD 186
Cdd:cd06432   97 DKVIFVDADQIVRTDLKELMDMDLK-GAPYGYTPFCD 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH