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Conserved domains on  [gi|672057974|ref|XP_008763377|]
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phospholipid phosphatase 2 isoform X1 [Rattus norvegicus]

Protein Classification

PAP2 phosphatase family protein( domain architecture ID 10130187)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to phospholipid phosphatase that catalyzes the conversion of phosphatidic acid to diacylglycerol

CATH:  1.20.144.10
EC:  3.1.3.-
Gene Ontology:  GO:0042577|GO:0046839|GO:0008610
SCOP:  3001110|4001226

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
38-183 7.65e-73

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


:

Pssm-ID: 239479  Cd Length: 150  Bit Score: 217.88  E-value: 7.65e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974  38 AIYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPSFLAVCDPDWSRVNCSGYVQVEV----CRGSPANVTEARLSFYSGHSS 113
Cdd:cd03384    1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIAdctcCTGDPDLIREARLSFPSGHAS 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974 114 FGMYCMLFLALYVQARLCWKWARLLRPTVQFFLVAFAIYVGYTRVSDNKHHWSDVLVGLLQGALVACLTV 183
Cdd:cd03384   81 LSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
38-183 7.65e-73

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 217.88  E-value: 7.65e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974  38 AIYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPSFLAVCDPDWSRVNCSGYVQVEV----CRGSPANVTEARLSFYSGHSS 113
Cdd:cd03384    1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIAdctcCTGDPDLIREARLSFPSGHAS 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974 114 FGMYCMLFLALYVQARLCWKWARLLRPTVQFFLVAFAIYVGYTRVSDNKHHWSDVLVGLLQGALVACLTV 183
Cdd:cd03384   81 LSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
acidPPc smart00014
Acid phosphatase homologues;
47-183 5.81e-27

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 99.73  E-value: 5.81e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974    47 LFGAAVSQSLTDLAKYMIGRLRPSFLAVCDPdwsrvncsgyvqveVCRGSPANVTEARLSFYSGHSSFGMYCMLFLALYv 126
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGDA--------------CCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLY- 65
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 672057974   127 qarlcwKWARLLRPTVQFFLVAFAIYVGYTRVSDNKHHWSDVLVGLLQGALVACLTV 183
Cdd:smart00014  66 ------LPARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
46-186 1.59e-20

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 83.24  E-value: 1.59e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974   46 FLFGAAVSQSLTDLAKYMIGRLRPSFLAVCDPDWSrvncsgyvqvevcrgSPANVTEARLSFYSGHSSFGMYCMLFLALY 125
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVP---------------APSTLPGLGYSFPSGHSATAFALALLLALL 66
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672057974  126 VqARLCWKWARLLRptvqFFLVAFAIYVGYTRVSDNKHHWSDVLVGLLQGALVACLTVCYV 186
Cdd:pfam01569  67 L-RRLRKIVRVLLA----LLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PLN02250 PLN02250
lipid phosphate phosphatase
40-195 9.89e-17

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 77.27  E-value: 9.89e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974  40 YKVLGtFLFGAAVSQSLTDLAKYMIGRLRPSFLAVCDPDWSRVNCSGYVQVeVCRGSPANVTEARLSFYSGHSSFGMYCM 119
Cdd:PLN02250  98 HAILG-LLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGVFHPVTTDV-LCTGAKSVIKEGHKSFPSGHTSWSFAGL 175
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672057974 120 LFLALYV--QARLCWKWARLLRPTVQFFLVAFAIYVGYTRVSDNKHHWSDVLVGLLQGALVAclTVCYVSdFFksrPP 195
Cdd:PLN02250 176 GFLSLYLsgKIRVFDRRGHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVA--SFCYLQ-FF---PP 247
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
42-183 4.84e-08

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 51.19  E-value: 4.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974  42 VLGTFLFGAAVSQSLTDLAKYMIGRLRPSflavcdpdwsrvncsgyvqvEVCRGSPANVTEARLSFYSGHSSFGMYCMLF 121
Cdd:COG0671   74 LLLLAALLLLLLLLLLLLLKYLFGRPRPF--------------------VVPDLELLLGTAGGYSFPSGHAAAAFALALV 133
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672057974 122 LALYVQARLCWkwarllrptvqFFLVAFAIYVGYTRVSDNKHHWSDVLVGLLQGALVACLTV 183
Cdd:COG0671  134 LALLLPRRWLA-----------ALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLL 184
 
Name Accession Description Interval E-value
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
38-183 7.65e-73

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 217.88  E-value: 7.65e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974  38 AIYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPSFLAVCDPDWSRVNCSGYVQVEV----CRGSPANVTEARLSFYSGHSS 113
Cdd:cd03384    1 RLYRFVGVFLFGLFATQLLTDLGKYVTGRLRPHFLDVCKPNYTDLTCSLDHQYIAdctcCTGDPDLIREARLSFPSGHAS 80
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974 114 FGMYCMLFLALYVQARLCWKWARLLRPTVQFFLVAFAIYVGYTRVSDNKHHWSDVLVGLLQGALVACLTV 183
Cdd:cd03384   81 LSMYAAVFLALYLQARLKLRGSRLLRPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIALFLV 150
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
45-186 3.47e-28

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 104.99  E-value: 3.47e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974  45 TFLFGAAVSQSLTDLAKYMIGRLRPSFLAVCDPDWSRVNCSGYVQVEVCRGSPANVTEARLSFYSGHSSFGMYCMLFLAL 124
Cdd:cd03390   50 GLLLSVSLNGVITNVLKNYAGRPRPDFLARCFPDGGTPSDTLVGIDICCTGDPGVLKEGRKSFPSGHSSFAFAGLGFLSL 129
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672057974 125 YVQARL-CWKWA-RLLRPTVQFFLVAFAIYVGYTRVSDNKHHWSDVLVGLLQGALVACLTVCYV 186
Cdd:cd03390  130 YLAGKLhIFDPRgSSWRLLLALLPLLLAILVAVSRTRDYRHHFSDVIAGSLIGLIIAYLSYRQY 193
acidPPc smart00014
Acid phosphatase homologues;
47-183 5.81e-27

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 99.73  E-value: 5.81e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974    47 LFGAAVSQSLTDLAKYMIGRLRPSFLAVCDPdwsrvncsgyvqveVCRGSPANVTEARLSFYSGHSSFGMYCMLFLALYv 126
Cdd:smart00014   1 ALLAVVSQLFNGVIKNYFGRPRPFFLSIGDA--------------CCTPNFLLTLEAGYSFPSGHTAFAFAFALFLLLY- 65
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 672057974   127 qarlcwKWARLLRPTVQFFLVAFAIYVGYTRVSDNKHHWSDVLVGLLQGALVACLTV 183
Cdd:smart00014  66 ------LPARAGRKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
40-183 1.98e-23

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 90.60  E-value: 1.98e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974  40 YKVLGTFLFGAAVSQSLTDLAKYMIGRLRPSFLAVCDPDwsrvncsgyvqvevcrGSPANVTEARLSFYSGHSSFGMYCM 119
Cdd:cd01610    2 RLLALLLLLALLAGLLLTGVLKYLFGRPRPYFLLRCGPD----------------GDPLLLTEGGYSFPSGHAAFAFALA 65
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672057974 120 LFLALYVqarlcwkWARLLRPTVQFFLVAFAIYVGYTRVSDNKHHWSDVLVGLLQGALVACLTV 183
Cdd:cd01610   66 LFLALLL-------PRRLLRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
46-186 1.59e-20

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 83.24  E-value: 1.59e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974   46 FLFGAAVSQSLTDLAKYMIGRLRPSFLAVCDPDWSrvncsgyvqvevcrgSPANVTEARLSFYSGHSSFGMYCMLFLALY 125
Cdd:pfam01569   2 LLLALALAGLLSSVLKDYFGRPRPFFLLLEGGLVP---------------APSTLPGLGYSFPSGHSATAFALALLLALL 66
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 672057974  126 VqARLCWKWARLLRptvqFFLVAFAIYVGYTRVSDNKHHWSDVLVGLLQGALVACLTVCYV 186
Cdd:pfam01569  67 L-RRLRKIVRVLLA----LLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLV 122
PLN02250 PLN02250
lipid phosphate phosphatase
40-195 9.89e-17

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 77.27  E-value: 9.89e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974  40 YKVLGtFLFGAAVSQSLTDLAKYMIGRLRPSFLAVCDPDWSRVNCSGYVQVeVCRGSPANVTEARLSFYSGHSSFGMYCM 119
Cdd:PLN02250  98 HAILG-LLFSVLITGVITDAIKDAVGRPRPDFFWRCFPDGKGVFHPVTTDV-LCTGAKSVIKEGHKSFPSGHTSWSFAGL 175
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 672057974 120 LFLALYV--QARLCWKWARLLRPTVQFFLVAFAIYVGYTRVSDNKHHWSDVLVGLLQGALVAclTVCYVSdFFksrPP 195
Cdd:PLN02250 176 GFLSLYLsgKIRVFDRRGHVAKLCIVFLPLLVAALVGVSRVDDYWHHWQDVFAGALIGLTVA--SFCYLQ-FF---PP 247
PLN02715 PLN02715
lipid phosphate phosphatase
40-185 2.07e-15

lipid phosphate phosphatase


Pssm-ID: 178317 [Multi-domain]  Cd Length: 327  Bit Score: 73.55  E-value: 2.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974  40 YKVLGtFLFGAAVSQSLTDLAKYMIGRLRPSFLAVCDPDWSRV-NCSGYVqveVCRGSPANVTEARLSFYSGHSSFGMYC 118
Cdd:PLN02715 123 HSILG-LLFAVLITGVITDSIKVATGRPRPNFYWRCFPDGKELyDALGGV---ICHGKAAEVKEGHKSFPSGHTSWSFAG 198
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672057974 119 MLFLALYVQARLCW--KWARLLRPTVQFFLVAFAIYVGYTRVSDNKHHWSDVLVGLLQGALVACLtvCY 185
Cdd:PLN02715 199 LTFLSLYLSGKIKAfnGEGHVAKLCLVIFPLLAACLVGISRVDDYWHHWQDVFAGALIGILVAAF--CY 265
PLN02731 PLN02731
Putative lipid phosphate phosphatase
40-195 1.58e-14

Putative lipid phosphate phosphatase


Pssm-ID: 178332  Cd Length: 333  Bit Score: 71.21  E-value: 1.58e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974  40 YKVLGtFLFGAAVSQSLTDLAKYMIGRLRPSFLAVCDPDWSRVNCS-GYVqveVCRGSPANVTEARLSFYSGHSSFGMYC 118
Cdd:PLN02731 117 HAVLG-LLYSVLVTAVLTDAIKNAVGRPRPDFFWRCFPDGKALYDSlGDV---ICHGDKSVIREGHKSFPSGHTSWSFSG 192
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 672057974 119 MLFLALYVQARLCW--KWARLLRPTVQFFLVAFAIYVGYTRVSDNKHHWSDVLVGLLQGALvaCLTVCYVSDFfksrPP 195
Cdd:PLN02731 193 LGFLSLYLSGKIQAfdGKGHVAKLCIVILPLLFAALVGISRVDDYWHHWQDVFAGGLLGLA--ISTICYLQFF----PP 265
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
40-179 2.87e-11

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 58.11  E-value: 2.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974  40 YKVLGTFLFGAAVSQSLTDLAKYMIGRLRPsflaVCDPDWSRvncsgyvqvevcrgspanvtearlSFYSGHSSFGMYCm 119
Cdd:cd03394    2 REGLLILAEAAALTAAVTEGLKFAVGRARP----DGSNNGYR------------------------SFPSGHTASAFAA- 52
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974 120 lflALYVQARLCWKWarllrptVQFFLVAFAIYVGYTRVSDNKHHWSDVLVGLLQGALVA 179
Cdd:cd03394   53 ---ATFLQYRYGWRW-------YGIPAYALASLVGASRVVANRHWLSDVLAGAAIGILVG 102
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
32-185 9.58e-09

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 53.00  E-value: 9.58e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974  32 FNNYVAAIYkVLGTFLFGAAVSQSLtdlaKYMIGRLRPsflavcdPDWSRVNCSGYvqvevcrgspanvtearlSFYSGH 111
Cdd:cd03392   58 KRRRRAALF-LLLALLGGGALNTLL----KLLVQRPRP-------PLHLLVPEGGY------------------SFPSGH 107
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 672057974 112 SSFGMYCMLFLALYVQARLcwkWARLLRPTVQFFLVAFAIYVGYTRVSDNKHHWSDVLVGLLQGAlvACLTVCY 185
Cdd:cd03392  108 AMGATVLYGFLAYLLARRL---PRRRVRILLLILAAILILLVGLSRLYLGVHYPSDVLAGWLLGL--AWLALLI 176
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
42-183 4.84e-08

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 51.19  E-value: 4.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974  42 VLGTFLFGAAVSQSLTDLAKYMIGRLRPSflavcdpdwsrvncsgyvqvEVCRGSPANVTEARLSFYSGHSSFGMYCMLF 121
Cdd:COG0671   74 LLLLAALLLLLLLLLLLLLKYLFGRPRPF--------------------VVPDLELLLGTAGGYSFPSGHAAAAFALALV 133
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 672057974 122 LALYVQARLCWkwarllrptvqFFLVAFAIYVGYTRVSDNKHHWSDVLVGLLQGALVACLTV 183
Cdd:COG0671  134 LALLLPRRWLA-----------ALLLALALLVGLSRVYLGVHYPSDVLAGALLGLAIALLLL 184
PAP2_lipid_A_1_phosphatase cd03389
PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from ...
7-179 3.25e-04

PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major constituents of the outer membrane in many gram-negative bacteria.


Pssm-ID: 239483  Cd Length: 186  Bit Score: 40.00  E-value: 3.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974   7 TATVVLVSSGEAYLVYTDRlYSRSDFNNYVAAIYKV--LGTFLFGA-AVSQSLTDLAKYMIGRLRPSFLAvcDPDWsrvn 83
Cdd:cd03389   33 KSGWYLIPSLLLFLLFRFG-DLRGLSAPSRARFPKAawAGLFLFATvALSGILVNLLKFIIGRARPKLLF--DDGL---- 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974  84 csgYVQVEVCRGSPANvtearlSFYSGHSS--FGMycmlFLALYvqarlcwkwarLLRPTVQFFLVAFAIYVGYTRVSDN 161
Cdd:cd03389  106 ---YGFDPFHADYAFT------SFPSGHSAtaGAA----AAALA-----------LLFPRYRWAFILLALLIAFSRVIVG 161
                        170
                 ....*....|....*...
gi 672057974 162 KHHWSDVLVGLLQGALVA 179
Cdd:cd03389  162 AHYPSDVIAGSLLGAVTA 179
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
57-181 3.48e-04

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 39.94  E-value: 3.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 672057974  57 TDLAKYMIGRLRPSF-LAVCDpDWSRVNCSGyvqvevcrgspanvteaRLSFYSGHSSFGMYCMLFLALYVqarlcwkWA 135
Cdd:cd03395   73 SGFLKPLVARLRPCNaLDGVR-LVVLGDQGG-----------------SYSFASSHAANSFALALFIWLFF-------RR 127
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 672057974 136 RLLRPtvqfFLVAFAIYVGYTRVSDNKHHWSDVLVGLLQGALVACL 181
Cdd:cd03395  128 GLFSP----VLLLWALLVGYSRVYVGVHYPGDVIAGALIGIISGLL 169
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
109-179 4.32e-04

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 39.56  E-value: 4.32e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 672057974 109 SGHSSFgmycMLFLALYVQARLCWKWARLLRPTVQFFLVAF----AIYVGYTRVSDNKHHWSDVLVGLLQGALVA 179
Cdd:cd03382   85 SSHSQF----MGFFAVYLLLFIYLRLGRLNSLVSRFLLSLGllllALLVSYSRVYLGYHTVSQVVVGAIVGILLG 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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