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Conserved domains on  [gi|667663697|ref|XP_008603680|]
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PDZ domain-containing protein [Beauveria bassiana ARSEF 2860]

Protein Classification

DegQ and PDZ domain-containing protein( domain architecture ID 11415758)

DegQ and PDZ domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
cpPDZ_Deg_HtrA-like super family cl49614
permuted PDZ domain of Deg/high-temperature requirement factor A (HtrA) family of housekeeping ...
 164-252 5.26e-20

permuted PDZ domain of Deg/high-temperature requirement factor A (HtrA) family of housekeeping serine proteases and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain of Deg/HtrA-type serine proteases that participate in folding and degradation of aberrant proteins, and in processing and maturation of native proteins. Typically, these proteases have an N-terminal serine protease domain and at least one C-terminal PDZ domain that recognizes substrates, and in some cases activates the protease function. An exception is yeast Nma11p which has two protease domains and four PDZ domains; its N-terminal half is comprised of a protease domain, followed by two PDZ domains, and its C-terminal half has a similar domain arrangement. HtrA-type proteases include the human HtrA1-4 and MBTPS2, tricorn protease, DegS, DegP and C-terminal processing peptidase, cyanobacterial serine proteases Hhoa, HhoB, and HtrA, and yeast Nma11p. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-termini of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains and as well as those with circular permutations and domain swapping of beta-strands. The canonical PDZ domain contains six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2); arranged as A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F. This Deg/HtrA family PDZ domain is a circularly permuted PDZ domain which places beta-strand A at the C-terminus. Another permutation exists in the PDZ superfamily which places both beta-strands A and B on the C-terminus.


The actual alignment was detected with superfamily member cd06786:

Pssm-ID: 483954 [Multi-domain]  Cd Length: 89  Bit Score: 83.39  E-value: 5.26e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667663697 164 CKGLGLDSGWEERLRRRITASGGLLVASKVLAGGPSCGRILPGDILLEVNGAVALQFDELEDVFNENVNGQVSISLLRSG 243
Cdd:cd06786    1 CRRLGLTPETEAAVRKAFPSETGMLVAETVLPEGPADGKLEEGDVLISVNGELITQFIRLEEILDENVGKTVELVVQRGG 80


                 ....*....
gi 667663697 244 QLVLGTIDV 252
Cdd:cd06786   81 EEITVTITV 89
DegQ super family cl43081
Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational ...
 14-253 8.15e-15

Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG0265:

Pssm-ID: 440035 [Multi-domain]  Cd Length: 274  Bit Score: 73.64  E-value: 8.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667663697  14 DPIHDFAFLKYDPGSIQNMKMDglslSSGGASVGQPVLVVGNDAGEATSIIDGAISRTDRNAP-EYDGPYSDF------- 85
Cdd:COG0265   45 DPLTDLAVLKIDAKDLPAAPLG----DSDKLRVGDWVLAIGNPFGLGQTVTAGIVSALGRSIGsSGGGTYDDFiqtdaai 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667663697  86 NisyymanmnlsGGSSGSPALGEDGLVLGMVS--GRRTDGA--ICFLLPTGPILQILCRLRQGQDVPRGDIqcqfvmkpi 161
Cdd:COG0265  121 N-----------PGNSGGPLVNLNGEVIGINTaiISRSGGSqgIGFAIPINLAKRVVEQLIETGRVRRGWL--------- 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667663697 162 heckGLGLDSGWEERLRR-RITASGGLLVASkVLAGGPSC-GRILPGDILLEVNGAVALQFDELED-VFNENVNGQVSIS 238
Cdd:COG0265  181 ----GVTIQPVTPELAEAlGLPEPEGVLVAR-VEPGSPAAkAGLRPGDVILAVDGKPVTSARDLQRlLASLKPGDTVTLT 255

                        250
                 ....*....|....*
gi 667663697 239 LLRSGQLVlgTIDVV 253
Cdd:COG0265  256 VLRGGKEL--TVTVT 268
PDZ_canonical super family cl49608
canonical PDZ domain; Canonical PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs ...
 257-313 2.04e-07

canonical PDZ domain; Canonical PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain. PDZ domains usually bind to short specific peptide sequences located at the C-terminal end of their partner proteins known as PDZ binding motifs. These domains can also interact with internal peptide motifs and certain lipids, and can take part in a head-to-tail oligomerization with other PDZ domains. The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. The canonical PDZ domain contains six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.


The actual alignment was detected with superfamily member pfam12812:

Pssm-ID: 483948 [Multi-domain]  Cd Length: 78  Bit Score: 48.04  E-value: 2.04e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 667663697  257 HIMPKCLAVNTSVAARGVYVAESTEPLMIGDGEP-GWIIQSLNGQAVSSLEGFLDRLK 313
Cdd:pfam12812  16 HDLSYQQARSYAIPIRGVYVSEASGSFKLSGGESkGWIITSVNNQPTPNLDTFIEVMK 73
 
Name Accession Description Interval E-value
cpPDZ1_ScNma111-like cd06786
circularly permuted first PDZ domain (PDZ1) of Saccharomyces cerevisiae pro-apoptotic serine ...
 164-252 5.26e-20

circularly permuted first PDZ domain (PDZ1) of Saccharomyces cerevisiae pro-apoptotic serine protease Nma111p and related domains; First PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain of the HtrA-type protease Saccharomyces cerevisiae Nma111p (also known as Ynm3p), and related domains. Nma111p is a nuclear serine protease which mediates apoptosis through proteolysis of the apoptotic inhibitor Bir1p. Nma111p is composed of two protease domains and four PDZ domains; its N-terminal half is comprised of a protease domain, followed by two PDZ domains, and its C-terminal half has a similar domain arrangement. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains and as well as those with circular permutations and domain swapping of beta-strands. The canonical PDZ domain contains six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2); arranged as A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F. This ScNma111-like PDZ1 domain is a circularly permuted PDZ domain which places beta-strand A on the C-terminus. Another permutation places both beta-strands A and B on the C-terminus.


Pssm-ID: 467625 [Multi-domain]  Cd Length: 89  Bit Score: 83.39  E-value: 5.26e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667663697 164 CKGLGLDSGWEERLRRRITASGGLLVASKVLAGGPSCGRILPGDILLEVNGAVALQFDELEDVFNENVNGQVSISLLRSG 243
Cdd:cd06786    1 CRRLGLTPETEAAVRKAFPSETGMLVAETVLPEGPADGKLEEGDVLISVNGELITQFIRLEEILDENVGKTVELVVQRGG 80


                 ....*....
gi 667663697 244 QLVLGTIDV 252
Cdd:cd06786   81 EEITVTITV 89
DegQ COG0265
Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational ...
 14-253 8.15e-15

Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440035 [Multi-domain]  Cd Length: 274  Bit Score: 73.64  E-value: 8.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667663697  14 DPIHDFAFLKYDPGSIQNMKMDglslSSGGASVGQPVLVVGNDAGEATSIIDGAISRTDRNAP-EYDGPYSDF------- 85
Cdd:COG0265   45 DPLTDLAVLKIDAKDLPAAPLG----DSDKLRVGDWVLAIGNPFGLGQTVTAGIVSALGRSIGsSGGGTYDDFiqtdaai 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667663697  86 NisyymanmnlsGGSSGSPALGEDGLVLGMVS--GRRTDGA--ICFLLPTGPILQILCRLRQGQDVPRGDIqcqfvmkpi 161
Cdd:COG0265  121 N-----------PGNSGGPLVNLNGEVIGINTaiISRSGGSqgIGFAIPINLAKRVVEQLIETGRVRRGWL--------- 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667663697 162 heckGLGLDSGWEERLRR-RITASGGLLVASkVLAGGPSC-GRILPGDILLEVNGAVALQFDELED-VFNENVNGQVSIS 238
Cdd:COG0265  181 ----GVTIQPVTPELAEAlGLPEPEGVLVAR-VEPGSPAAkAGLRPGDVILAVDGKPVTSARDLQRlLASLKPGDTVTLT 255

                        250
                 ....*....|....*
gi 667663697 239 LLRSGQLVlgTIDVV 253
Cdd:COG0265  256 VLRGGKEL--TVTVT 268
Trypsin_2 pfam13365
Trypsin-like peptidase domain; This family includes trypsin-like peptidase domains.
 2-115 2.39e-09

Trypsin-like peptidase domain; This family includes trypsin-like peptidase domains.


Pssm-ID: 433149 [Multi-domain]  Cd Length: 142  Bit Score: 55.12  E-value: 2.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667663697    2 DQEAVSCRPLYIDPIHDFAFLK--YDPGSIQNMKMDglslSSGGASVGQPVLVVGN-DAGEATSIIDGAISRTDRNAPEY 78
Cdd:pfam13365  36 DGREYPATVVARDPDLDLALLRvsGDGRGLPPLPLG----DSEPLVGGERVYAVGYpLGGEKLSLSEGIVSGVDEGRDGG 111

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 667663697   79 DGPYsdfnisYYMANMNLSGGSSGSPALGEDGLVLGM 115
Cdd:pfam13365 112 DDGR------VIQTDAALSPGSSGGPVFDADGRVVGI 142
PDZ_1 pfam12812
PDZ-like domain; PDZ domains are found in diverse signalling proteins in bacteria, yeasts, ...
 257-313 2.04e-07

PDZ-like domain; PDZ domains are found in diverse signalling proteins in bacteria, yeasts, plants, insects and vertebrates. this is a family of PDZ-like domains from bacteria, plants and fungi.


Pssm-ID: 372324 [Multi-domain]  Cd Length: 78  Bit Score: 48.04  E-value: 2.04e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 667663697  257 HIMPKCLAVNTSVAARGVYVAESTEPLMIGDGEP-GWIIQSLNGQAVSSLEGFLDRLK 313
Cdd:pfam12812  16 HDLSYQQARSYAIPIRGVYVSEASGSFKLSGGESkGWIITSVNNQPTPNLDTFIEVMK 73
PDZ2-4_Nma111p-like cd06719
second and fourth PDZ domains (PDZ2 and 4) of Saccharomyces cerevisiae pro-apoptotic serine ...
 257-322 3.58e-07

second and fourth PDZ domains (PDZ2 and 4) of Saccharomyces cerevisiae pro-apoptotic serine protease Nma111p and related domains; Second and fourth PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens 1)) domains of the HtrA-type protease Saccharomyces cerevisiae Nma11p (also known as Ynm3p), and related domains. Nma111p is a nuclear serine protease which mediates apoptosis through proteolysis of the apoptotic inhibitor Bir1p. Nma111p is composed of two protease domains and four PDZ domains; its N-terminal half is comprised of a protease domain, followed by two PDZ domains, and its C-terminal half has a similar domain arrangement. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminus of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping of beta-strands. The canonical PDZ domain contains six beta-strands (A-F) and two alpha-helices (alpha-helix 1 and 2), arranged as beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F. One permutation places beta-strand A at the C-terminus, another permutation places both beta-strands A and B at the C-terminus. This Nma111p-like family PDZ2 and PDZ4 domains show similarity to permuted PDZ domains.


Pssm-ID: 467617 [Multi-domain]  Cd Length: 79  Bit Score: 47.23  E-value: 3.58e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 667663697 257 HIMPKCLAVNTSVAARGVYVAESTEPLMIGDGEP-GWIIQSLNGQAVSSLEGFLDRLKLLHKGQAVV 322
Cdd:cd06719   11 HDLSYQQARSYAIPVRGVYVSEASGSFKLAGGISkGWIITSVNNQPTPNLDTFIEVMKTIPDNSRVR 77
SdrC COG3480
Predicted secreted protein YlbL, contains PDZ domain [Signal transduction mechanisms];
186-279 1.53e-03

Predicted secreted protein YlbL, contains PDZ domain [Signal transduction mechanisms];


Pssm-ID: 442703 [Multi-domain]  Cd Length: 344  Bit Score: 40.18  E-value: 1.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667663697 186 GLLVASkVLAGGPSCGRILPGDILLEVNGAVALQFDELEDVFNENVNGQ-VSISLLRSGQLVlgTIDVVnlhhimPKCLA 264
Cdd:COG3480  139 GVYVAS-VLEGSPADGVLQPGDVITAVDGKPVTTAEDLRDALAAKKPGDtVTLTVTRDGKEK--TVTVT------LVKLP 209

                         90
                 ....*....|....*
gi 667663697 265 VNTSVAARGVYVAES 279
Cdd:COG3480  210 DDDGRAGIGISLVTK 224
 
Name Accession Description Interval E-value
cpPDZ1_ScNma111-like cd06786
circularly permuted first PDZ domain (PDZ1) of Saccharomyces cerevisiae pro-apoptotic serine ...
 164-252 5.26e-20

circularly permuted first PDZ domain (PDZ1) of Saccharomyces cerevisiae pro-apoptotic serine protease Nma111p and related domains; First PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain of the HtrA-type protease Saccharomyces cerevisiae Nma111p (also known as Ynm3p), and related domains. Nma111p is a nuclear serine protease which mediates apoptosis through proteolysis of the apoptotic inhibitor Bir1p. Nma111p is composed of two protease domains and four PDZ domains; its N-terminal half is comprised of a protease domain, followed by two PDZ domains, and its C-terminal half has a similar domain arrangement. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains and as well as those with circular permutations and domain swapping of beta-strands. The canonical PDZ domain contains six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2); arranged as A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F. This ScNma111-like PDZ1 domain is a circularly permuted PDZ domain which places beta-strand A on the C-terminus. Another permutation places both beta-strands A and B on the C-terminus.


Pssm-ID: 467625 [Multi-domain]  Cd Length: 89  Bit Score: 83.39  E-value: 5.26e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667663697 164 CKGLGLDSGWEERLRRRITASGGLLVASKVLAGGPSCGRILPGDILLEVNGAVALQFDELEDVFNENVNGQVSISLLRSG 243
Cdd:cd06786    1 CRRLGLTPETEAAVRKAFPSETGMLVAETVLPEGPADGKLEEGDVLISVNGELITQFIRLEEILDENVGKTVELVVQRGG 80


                 ....*....
gi 667663697 244 QLVLGTIDV 252
Cdd:cd06786   81 EEITVTITV 89
DegQ COG0265
Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational ...
 14-253 8.15e-15

Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440035 [Multi-domain]  Cd Length: 274  Bit Score: 73.64  E-value: 8.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667663697  14 DPIHDFAFLKYDPGSIQNMKMDglslSSGGASVGQPVLVVGNDAGEATSIIDGAISRTDRNAP-EYDGPYSDF------- 85
Cdd:COG0265   45 DPLTDLAVLKIDAKDLPAAPLG----DSDKLRVGDWVLAIGNPFGLGQTVTAGIVSALGRSIGsSGGGTYDDFiqtdaai 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667663697  86 NisyymanmnlsGGSSGSPALGEDGLVLGMVS--GRRTDGA--ICFLLPTGPILQILCRLRQGQDVPRGDIqcqfvmkpi 161
Cdd:COG0265  121 N-----------PGNSGGPLVNLNGEVIGINTaiISRSGGSqgIGFAIPINLAKRVVEQLIETGRVRRGWL--------- 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667663697 162 heckGLGLDSGWEERLRR-RITASGGLLVASkVLAGGPSC-GRILPGDILLEVNGAVALQFDELED-VFNENVNGQVSIS 238
Cdd:COG0265  181 ----GVTIQPVTPELAEAlGLPEPEGVLVAR-VEPGSPAAkAGLRPGDVILAVDGKPVTSARDLQRlLASLKPGDTVTLT 255

                        250
                 ....*....|....*
gi 667663697 239 LLRSGQLVlgTIDVV 253
Cdd:COG0265  256 VLRGGKEL--TVTVT 268
Trypsin_2 pfam13365
Trypsin-like peptidase domain; This family includes trypsin-like peptidase domains.
 2-115 2.39e-09

Trypsin-like peptidase domain; This family includes trypsin-like peptidase domains.


Pssm-ID: 433149 [Multi-domain]  Cd Length: 142  Bit Score: 55.12  E-value: 2.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667663697    2 DQEAVSCRPLYIDPIHDFAFLK--YDPGSIQNMKMDglslSSGGASVGQPVLVVGN-DAGEATSIIDGAISRTDRNAPEY 78
Cdd:pfam13365  36 DGREYPATVVARDPDLDLALLRvsGDGRGLPPLPLG----DSEPLVGGERVYAVGYpLGGEKLSLSEGIVSGVDEGRDGG 111

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 667663697   79 DGPYsdfnisYYMANMNLSGGSSGSPALGEDGLVLGM 115
Cdd:pfam13365 112 DDGR------VIQTDAALSPGSSGGPVFDADGRVVGI 142
PDZ_1 pfam12812
PDZ-like domain; PDZ domains are found in diverse signalling proteins in bacteria, yeasts, ...
 257-313 2.04e-07

PDZ-like domain; PDZ domains are found in diverse signalling proteins in bacteria, yeasts, plants, insects and vertebrates. this is a family of PDZ-like domains from bacteria, plants and fungi.


Pssm-ID: 372324 [Multi-domain]  Cd Length: 78  Bit Score: 48.04  E-value: 2.04e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 667663697  257 HIMPKCLAVNTSVAARGVYVAESTEPLMIGDGEP-GWIIQSLNGQAVSSLEGFLDRLK 313
Cdd:pfam12812  16 HDLSYQQARSYAIPIRGVYVSEASGSFKLSGGESkGWIITSVNNQPTPNLDTFIEVMK 73
PDZ2-4_Nma111p-like cd06719
second and fourth PDZ domains (PDZ2 and 4) of Saccharomyces cerevisiae pro-apoptotic serine ...
 257-322 3.58e-07

second and fourth PDZ domains (PDZ2 and 4) of Saccharomyces cerevisiae pro-apoptotic serine protease Nma111p and related domains; Second and fourth PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens 1)) domains of the HtrA-type protease Saccharomyces cerevisiae Nma11p (also known as Ynm3p), and related domains. Nma111p is a nuclear serine protease which mediates apoptosis through proteolysis of the apoptotic inhibitor Bir1p. Nma111p is composed of two protease domains and four PDZ domains; its N-terminal half is comprised of a protease domain, followed by two PDZ domains, and its C-terminal half has a similar domain arrangement. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminus of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping of beta-strands. The canonical PDZ domain contains six beta-strands (A-F) and two alpha-helices (alpha-helix 1 and 2), arranged as beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F. One permutation places beta-strand A at the C-terminus, another permutation places both beta-strands A and B at the C-terminus. This Nma111p-like family PDZ2 and PDZ4 domains show similarity to permuted PDZ domains.


Pssm-ID: 467617 [Multi-domain]  Cd Length: 79  Bit Score: 47.23  E-value: 3.58e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 667663697 257 HIMPKCLAVNTSVAARGVYVAESTEPLMIGDGEP-GWIIQSLNGQAVSSLEGFLDRLKLLHKGQAVV 322
Cdd:cd06719   11 HDLSYQQARSYAIPVRGVYVSEASGSFKLAGGISkGWIITSVNNQPTPNLDTFIEVMKTIPDNSRVR 77
PDZ_canonical cd00136
canonical PDZ domain; Canonical PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs ...
 165-214 1.01e-03

canonical PDZ domain; Canonical PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain. PDZ domains usually bind to short specific peptide sequences located at the C-terminal end of their partner proteins known as PDZ binding motifs. These domains can also interact with internal peptide motifs and certain lipids, and can take part in a head-to-tail oligomerization with other PDZ domains. The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. The canonical PDZ domain contains six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.


Pssm-ID: 467153 [Multi-domain]  Cd Length: 81  Bit Score: 37.52  E-value: 1.01e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 667663697 165 KGLGLdsgweeRLRRRITASGGLLVaSKVLAGGPS--CGRILPGDILLEVNG 214
Cdd:cd00136   10 GGLGF------SIRGGKDGGGGIFV-SRVEPGGPAarDGRLRVGDRILEVNG 54
SdrC COG3480
Predicted secreted protein YlbL, contains PDZ domain [Signal transduction mechanisms];
186-279 1.53e-03

Predicted secreted protein YlbL, contains PDZ domain [Signal transduction mechanisms];


Pssm-ID: 442703 [Multi-domain]  Cd Length: 344  Bit Score: 40.18  E-value: 1.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 667663697 186 GLLVASkVLAGGPSCGRILPGDILLEVNGAVALQFDELEDVFNENVNGQ-VSISLLRSGQLVlgTIDVVnlhhimPKCLA 264
Cdd:COG3480  139 GVYVAS-VLEGSPADGVLQPGDVITAVDGKPVTTAEDLRDALAAKKPGDtVTLTVTRDGKEK--TVTVT------LVKLP 209

                         90
                 ....*....|....*
gi 667663697 265 VNTSVAARGVYVAES 279
Cdd:COG3480  210 DDDGRAGIGISLVTK 224
Mycop_pep_DUF31 pfam01732
Mycoplasma peptidase (DUF31); This domain is found in various uncharacterized proteins and ...
 62-118 2.17e-03

Mycoplasma peptidase (DUF31); This domain is found in various uncharacterized proteins and putative lipoproteins from mycoplasmas. Although its function is not clear, it has been suggested that this is a serine protease domain; sequence analysis revealed that the amino acid sequence is similar to that of serine proteases. It is related to pathogenicity as this domain is present in proteins encoded by animal and human pathogenic Mycoplasmas. It has been proposed that the Ig binding protein M may function together with this domain playing a role in evading host Ig-mediated defense against the MIB-MIP (mycoplasma Ig binding protein (MIB) and mycoplasma Ig protease (MIP)) system, which is a novel mechanism that protects mycoplasma against host immune response.


Pssm-ID: 426401  Cd Length: 353  Bit Score: 39.42  E-value: 2.17e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 667663697   62 SIIDGAISRTDRNAPEydGPYSDFNISYYMANMNLSGGSSGSPALGEDGLVLGMVSG 118
Cdd:pfam01732 299 GINDAFINNPKSNYHS--KKYTNYGLGYLLKNSSLYGGASGSLVINQNNQLVGIYFG 353
PDZ_FRMPD1_3_4-like cd06769
PDZ domain of FERM and PDZ domain-containing protein 1 (FRMPD1), FRMPD3, FRMPD4, and related ...
 187-242 2.75e-03

PDZ domain of FERM and PDZ domain-containing protein 1 (FRMPD1), FRMPD3, FRMPD4, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain of FRMPD1, FRMPD3, FRMPD4, and related domains. FRMPD1 (also known as FERM domain-containing protein 2, FRMD2), inhibits the malignant phenotype of lung cancer by activating the Hippo pathway via interaction with WWC3; the FRMPD1 PDZ domain binds WWC3. FRMPD3 is a target gene of the neuron-specific transcription factor NPAS4 that is involved in synaptic plasticity. FRMPD4 (also known as PDZ domain-containing protein 10, PDZD10, PDZK10, PSD-95-interacting regulator of spine morphogenesis, and Preso) regulates dendritic spine morphogenesis, and mGluR1/5 signaling; the FRMPD4 PDZ domain binds PAK-interacting exchange factor-beta (betaPix). PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This FRMPD1,3,4-like family domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.


Pssm-ID: 467250 [Multi-domain]  Cd Length: 75  Bit Score: 36.07  E-value: 2.75e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 667663697 187 LLVASkVLAGGPSCGRILPGDILLEVNGavalqfdelEDVfnENVNGQVSISLLRS 242
Cdd:cd06769   22 VVVRS-VTPGGPSEGKLLPGDQILKINN---------EPV--EDLPRERVIDLIRE 65
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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