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Conserved domains on  [gi|585707535|ref|XP_006824002|]
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PREDICTED: cyclin-F-like [Saccoglossus kowalevskii]

Protein Classification

cyclin F( domain architecture ID 17778166)

cyclin F functions as the substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle

CATH:  1.20.1280.50|1.10.472.10
Gene Symbol:  CCNF
Gene Ontology:  GO:0006511|GO:0019005|GO:0000079|GO:0019901
PubMed:  20596027|11178263|31898225|30185601|1842340
SCOP:  4001927|4001102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 293-387 7.07e-60

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410225  Cd Length: 95  Bit Score: 196.77  E-value: 7.07e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 293 TSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSRLLEKDIVTIREAAWLTDGTYS 372
Cdd:cd20521    1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTYK 80

                         90
                 ....*....|....*
gi 585707535 373 YEEVVRMMGEIVAVL 387
Cdd:cd20521   81 YEDVVRMMGEIVAAL 95
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 415-526 3.53e-57

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


:

Pssm-ID: 410226  Cd Length: 112  Bit Score: 190.14  E-value: 3.53e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 415 CLAMFITEMTLLHVEFGLFTVANLAASAVFLARVLLLQDFPWPNHMVDFTFFTVDDITPCALLLFRKCFVEPSLTDHRDV 494
Cdd:cd20522    1 CLASYICELSLLHTELGRYSPAVIAASCLLLARVLLNQALPWPSQLEEFTGFSLEDLLSCVLHLHKKCFHEDSPKDYRNV 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 585707535 495 TLMAVKQRYSEENRLEVAKIEVMDYTELCNLL 526
Cdd:cd20522   81 SLTAVKQRYEDERFLSISKIKVMSYEELCALL 112
F-box_FBXO1 cd22082
F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called ...
 19-70 6.17e-26

F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called FBX1, or cyclin-F, is a substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 438854  Cd Length: 52  Bit Score: 100.78  E-value: 6.17e-26
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 585707535  19 NVWCLPEEVLVLLVKGLPAKDLLSMRAVHSKFRNIIDTNPSIWSTVNFRGEW 70
Cdd:cd22082    1 TLWSLPEEVLLHILKGLPIKDLLNMRAVHSRFKDLIDSNPSLWANASFQGSW 52
 
Name Accession Description Interval E-value
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 293-387 7.07e-60

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 196.77  E-value: 7.07e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 293 TSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSRLLEKDIVTIREAAWLTDGTYS 372
Cdd:cd20521    1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTYK 80

                         90
                 ....*....|....*
gi 585707535 373 YEEVVRMMGEIVAVL 387
Cdd:cd20521   81 YEDVVRMMGEIVAAL 95
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 415-526 3.53e-57

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410226  Cd Length: 112  Bit Score: 190.14  E-value: 3.53e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 415 CLAMFITEMTLLHVEFGLFTVANLAASAVFLARVLLLQDFPWPNHMVDFTFFTVDDITPCALLLFRKCFVEPSLTDHRDV 494
Cdd:cd20522    1 CLASYICELSLLHTELGRYSPAVIAASCLLLARVLLNQALPWPSQLEEFTGFSLEDLLSCVLHLHKKCFHEDSPKDYRNV 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 585707535 495 TLMAVKQRYSEENRLEVAKIEVMDYTELCNLL 526
Cdd:cd20522   81 SLTAVKQRYEDERFLSISKIKVMSYEELCALL 112
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 270-392 6.68e-31

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 117.62  E-value: 6.68e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535  270 FQFVLESRSTNTHRMFEFQSGLNTSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVIC 349
Cdd:pfam00134   5 YLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIA 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 585707535  350 SRLLEKDIVTIREAAWLTDGTYSYEEVVRMMGEIVAVLHGQIR 392
Cdd:pfam00134  85 AKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
F-box_FBXO1 cd22082
F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called ...
 19-70 6.17e-26

F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called FBX1, or cyclin-F, is a substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438854  Cd Length: 52  Bit Score: 100.78  E-value: 6.17e-26
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 585707535  19 NVWCLPEEVLVLLVKGLPAKDLLSMRAVHSKFRNIIDTNPSIWSTVNFRGEW 70
Cdd:cd22082    1 TLWSLPEEVLLHILKGLPIKDLLNMRAVHSRFKDLIDSNPSLWANASFQGSW 52
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
288-487 1.54e-18

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 89.06  E-value: 1.54e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 288 QSGLNTSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSRLLEKDIVTIREAAWLT 367
Cdd:COG5024  205 QSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCPSIKDLVYAT 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 368 DGTYSYEEVVRMMGEIVAVLHGQIRIPTVLDYLHLFCDLAAVDKQTECLAMFITEMTLLHVEFGLFTVANLAASAVFLAR 447
Cdd:COG5024  285 DGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSRTPAKFSSEISPVDYKFIQISPSWCAAAAMYLSR 364

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 585707535 448 VLLLQDfPWPNHMVDFT-FFTVDDITPCALLLfRKCFVEPS 487
Cdd:COG5024  365 KILSQN-QWDRTLIHYSgNYTNPDLKPLNESN-KENLQNPS 403
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 394-515 1.27e-17

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 79.20  E-value: 1.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535  394 PTVLDYLHLF--CDLAAVDKQTECLAMFITEMTLLHVEFGLFTVANLAASAVFLARvLLLQDFPWPNHMVDFTFFTVDDI 471
Cdd:pfam02984   1 PTPLSFLRRFskAADYLHDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLAR-KTLNSPEWTETLEHYTGYSEEDL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 585707535  472 TPCALLLfrkcfvEPSLTDHRDVTLMAVKQRYSEENRLEVAKIE 515
Cdd:pfam02984  80 KPCVKLL------LELLLNAPSSKLQAVRRKYSSSKFMKVSTLP 117
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 301-384 2.40e-10

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 57.22  E-value: 2.40e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535   301 DWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSRLLEKDiVTIREAAWLTdGTYSYEEVVRMM 380
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETP-PWTKELVHYT-GYFTEEEILRME 78


                   ....
gi 585707535   381 GEIV 384
Cdd:smart00385  79 RLLL 82
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 398-480 1.05e-09

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 55.68  E-value: 1.05e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535   398 DYLHLFCDLAAVDKQTECLAMFITEMTLLHVEFGLFTVANLAASAVFLARvLLLQDFPWPNHMVDFT-FFTVDDITPCAL 476
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLAS-KTEETPPWTKELVHYTgYFTEEEILRMER 79


                   ....
gi 585707535   477 LLFR 480
Cdd:smart00385  80 LLLE 83
FBOX smart00256
A Receptor for Ubiquitination Targets;
23-61 2.00e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 42.04  E-value: 2.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 585707535    23 LPEEVLVLLVKGLPAKDLLSMRAVHSKFRNIIDtNPSIW 61
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLID-SHDFW 38
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 20-64 1.21e-03

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 37.08  E-value: 1.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 585707535   20 VWCLPEEVLVLLVKGLPAKDLLSMRAVHSKFRNIIDtNPSIWSTV 64
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELAS-DDSLWRRL 44
 
Name Accession Description Interval E-value
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 293-387 7.07e-60

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 196.77  E-value: 7.07e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 293 TSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSRLLEKDIVTIREAAWLTDGTYS 372
Cdd:cd20521    1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRKVPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTYK 80

                         90
                 ....*....|....*
gi 585707535 373 YEEVVRMMGEIVAVL 387
Cdd:cd20521   81 YEDVVRMMGEIVAAL 95
CYCLIN_CCNF_rpt2 cd20522
second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, ...
 415-526 3.53e-57

second cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410226  Cd Length: 112  Bit Score: 190.14  E-value: 3.53e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 415 CLAMFITEMTLLHVEFGLFTVANLAASAVFLARVLLLQDFPWPNHMVDFTFFTVDDITPCALLLFRKCFVEPSLTDHRDV 494
Cdd:cd20522    1 CLASYICELSLLHTELGRYSPAVIAASCLLLARVLLNQALPWPSQLEEFTGFSLEDLLSCVLHLHKKCFHEDSPKDYRNV 80

                         90       100       110
                 ....*....|....*....|....*....|..
gi 585707535 495 TLMAVKQRYSEENRLEVAKIEVMDYTELCNLL 526
Cdd:cd20522   81 SLTAVKQRYEDERFLSISKIKVMSYEELCALL 112
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 270-392 6.68e-31

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 117.62  E-value: 6.68e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535  270 FQFVLESRSTNTHRMFEFQSGLNTSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVIC 349
Cdd:pfam00134   5 YLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIA 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 585707535  350 SRLLEKDIVTIREAAWLTDGTYSYEEVVRMMGEIVAVLHGQIR 392
Cdd:pfam00134  85 AKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
F-box_FBXO1 cd22082
F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called ...
 19-70 6.17e-26

F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called FBX1, or cyclin-F, is a substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438854  Cd Length: 52  Bit Score: 100.78  E-value: 6.17e-26
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 585707535  19 NVWCLPEEVLVLLVKGLPAKDLLSMRAVHSKFRNIIDTNPSIWSTVNFRGEW 70
Cdd:cd22082    1 TLWSLPEEVLLHILKGLPIKDLLNMRAVHSRFKDLIDSNPSLWANASFQGSW 52
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 284-388 6.98e-23

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 94.78  E-value: 6.98e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 284 MFEFQSGLNTSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSRLLEKDIVTIREA 363
Cdd:cd20562   30 MEKIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVNRQRLQLLGVSCMLIASKYEEICAPQVEEF 109

                         90       100
                 ....*....|....*....|....*
gi 585707535 364 AWLTDGTYSYEEVVRMMGEIVAVLH 388
Cdd:cd20562  110 CYITDNTYTKQEVLEMEIDVLNALQ 134
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 286-387 8.49e-23

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 94.24  E-value: 8.49e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 286 EFQSGLNTSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSRLLEKDIVTIREAAW 365
Cdd:cd20504   25 RKQPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLVGTACMFIAAKYEEIYPPEVEEFVY 104

                         90       100
                 ....*....|....*....|..
gi 585707535 366 LTDGTYSYEEVVRMMGEIVAVL 387
Cdd:cd20504  105 ITDDTYTKKQVLRMEHLVLKVL 126
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 274-388 1.77e-21

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 90.67  E-value: 1.77e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 274 LESRSTNTHRMFEFQSGLNTSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSRLL 353
Cdd:cd20507   15 LEKKYAIDPDYLSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQLVGVTALLIASKYE 94

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 585707535 354 EKDIVTIREAAWLTDGTYSYEEVVRMMGEIVAVLH 388
Cdd:cd20507   95 EIYPPEIKDFVYITDNAYTREEILQMERDILKTLD 129
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
288-487 1.54e-18

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 89.06  E-value: 1.54e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 288 QSGLNTSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSRLLEKDIVTIREAAWLT 367
Cdd:COG5024  205 QSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGISALFIASKYEEVNCPSIKDLVYAT 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 368 DGTYSYEEVVRMMGEIVAVLHGQIRIPTVLDYLHLFCDLAAVDKQTECLAMFITEMTLLHVEFGLFTVANLAASAVFLAR 447
Cdd:COG5024  285 DGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASDYDIFSRTPAKFSSEISPVDYKFIQISPSWCAAAAMYLSR 364

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 585707535 448 VLLLQDfPWPNHMVDFT-FFTVDDITPCALLLfRKCFVEPS 487
Cdd:COG5024  365 KILSQN-QWDRTLIHYSgNYTNPDLKPLNESN-KENLQNPS 403
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 288-387 5.55e-18

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 80.87  E-value: 5.55e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 288 QSGLNTSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSRLLEKDIVTIREAAWLT 367
Cdd:cd20561   29 QPDITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYIT 108

                         90       100
                 ....*....|....*....|
gi 585707535 368 DGTYSYEEVVRMMGEIVAVL 387
Cdd:cd20561  109 DDTYTKKQVLRMEHLVLKVL 128
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 285-387 7.07e-18

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 80.76  E-value: 7.07e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 285 FEFQSGLNTSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSRLLEKDIVTIREAA 364
Cdd:cd20508   37 LEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKKVVKKEKLQLLGATAILIASKFDERCPPCVDDFL 116

                         90       100
                 ....*....|....*....|...
gi 585707535 365 WLTDGTYSYEEVVRMMGEIVAVL 387
Cdd:cd20508  117 YICDDAYTREELLKMEREILKTL 139
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 394-515 1.27e-17

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 79.20  E-value: 1.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535  394 PTVLDYLHLF--CDLAAVDKQTECLAMFITEMTLLHVEFGLFTVANLAASAVFLARvLLLQDFPWPNHMVDFTFFTVDDI 471
Cdd:pfam02984   1 PTPLSFLRRFskAADYLHDLELRTLAKYLLELTLLDYDFLKYPPSLIAAAAVYLAR-KTLNSPEWTETLEHYTGYSEEDL 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 585707535  472 TPCALLLfrkcfvEPSLTDHRDVTLMAVKQRYSEENRLEVAKIE 515
Cdd:pfam02984  80 KPCVKLL------LELLLNAPSSKLQAVRRKYSSSKFMKVSTLP 117
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 284-387 1.67e-17

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 80.08  E-value: 1.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 284 MFEFQSGLNTSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSRLLEKDIVTIREA 363
Cdd:cd20567   42 YMSQQPDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSVKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDF 121

                         90       100
                 ....*....|....*....|....
gi 585707535 364 AWLTDGTYSYEEVVRMMGEIVAVL 387
Cdd:cd20567  122 VYISDNAYTRKQILVMEKTMLNTL 145
CYCLIN_CCNO-like_rpt2 cd20537
second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of ...
 394-480 9.00e-17

second cyclin box found in cyclin-O (CCNO) and similar proteins; This subfamily is composed of CCNO and similar proteins including Schizosaccharomyces pombe meiosis-specific cyclin rem1, Drosophila melanogaster G2/mitotic-specific cyclin-A (CCNA), and Candida albicans G1/S-specific cyclin CCN1, among others. Rem1 is required for pre-meiotic DNA synthesis and S phase progression. CCNA is essential for the control of the cell cycle at the G2/M (mitosis) transition. CCN1 is essential for the control of the cell cycle at the G1/S (start) transition and for maintenance of filamentous growth. CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It is involved in the activation of cyclin-dependent kinase 2. Members of this subfamily contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410240 [Multi-domain]  Cd Length: 91  Bit Score: 75.81  E-value: 9.00e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 394 PTVLDYLHLFCDLAAVDKQTECLAMFITEMTLLHVEFGLFTVANLAASAVFLARVLLLQDFPWPNHMVDFTFFTVDDITP 473
Cdd:cd20537    1 PTPLSFLRRYLSLLGLDEKVRHLARYLLELSLLDYEFLKYRPSLIAAAALYLARKILGEPPPSPQLLQLVTGYSENDLQE 80


                 ....*..
gi 585707535 474 CALLLFR 480
Cdd:cd20537   81 CAKELLE 87
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 296-379 1.48e-15

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 72.74  E-value: 1.48e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 296 RYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSRLLEKDIVTIREAAWLTDGTYSYEE 375
Cdd:cd20542    1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKKQ 80


                 ....
gi 585707535 376 VVRM 379
Cdd:cd20542   81 VLRM 84
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 260-387 9.61e-15

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 72.57  E-value: 9.61e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 260 LCKEQVCETVFQFVLESRSTNTHRMFEF--QSGLNTSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRAN 337
Cdd:cd20560   31 LAVPEYAEDIHQYLREAELKHRPKPGYMrkQPDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSVLRGK 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 585707535 338 LQLLGISAMVICSRLLEKDIVTIREAAWLTDGTYSYEEVVRMMGEIVAVL 387
Cdd:cd20560  111 LQLVGTAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVL 160
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 260-379 1.75e-14

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 70.66  E-value: 1.75e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 260 LCKEQVCEtVFQFV--LESRSTNTHRMFEFQSgLNTSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRAN 337
Cdd:cd20566    4 LCSDYVKD-IYQYLrqLEVQQSIRPHYLDGKE-INERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRKK 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 585707535 338 LQLLGISAMVICSRLLEKDIVTIREAAWLTDGTYSYEEVVRM 379
Cdd:cd20566   82 LQLVGVTALLLASKYEEMYSPEIGDFVYITDNAYTKAQIREM 123
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 275-379 1.99e-14

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 70.42  E-value: 1.99e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 275 ESRSTNTHRMFEFQSGLNTSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQ---PTTraNLQLLGISAMVICSR 351
Cdd:cd20519   16 EELYKRDRDFLNRHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQtnvPKT--QLQLIGITCLFIAAK 93

                         90       100
                 ....*....|....*....|....*...
gi 585707535 352 LLEKDIVTIREAAWLTDGTYSYEEVVRM 379
Cdd:cd20519   94 LEEIYPPKLSEFAYVTDGACTEDEILTM 121
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 274-378 4.40e-14

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 69.63  E-value: 4.40e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 274 LESRSTNTHRMFEFQSGLNTSMRYILVDWLVEVtgMKDFSNL--TLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSR 351
Cdd:cd20568   19 LELKTLPNPNYMDDQKELRWKMRGILVDWLVEV--HEKFRLLpeTLFLAVNIIDRFLSKRVVSLNKLQLVGISALFIASK 96

                         90       100
                 ....*....|....*....|....*..
gi 585707535 352 LLEKDIVTIREAAWLTDGTYSYEEVVR 378
Cdd:cd20568   97 YEEVNSPSIKNFAYMTDGAYTVEDILR 123
CYCLIN_CCNA_rpt2 cd20505
second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 394-507 4.97e-14

second cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410209 [Multi-domain]  Cd Length: 110  Bit Score: 68.86  E-value: 4.97e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 394 PTVLDYLHLFCDLAAVDKQTECLAMFITEMTLLHVEFGL-FTVANLAASAVFLARvLLLQDFPWPNHMVDFTFFTVDDIT 472
Cdd:cd20505    1 PTSNWFLERFLKHSNADEKTKSLAMYLCELSLIDADPYLkYLPSVIAAAAVCLAN-HTLGNEVWPQKLARSTGYSLEDLL 79

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 585707535 473 PCALLLFRKCFVEPSLtdhrdvTLMAVKQRYSEEN 507
Cdd:cd20505   80 PCLRDLHRTFLNAPSS------PQQAIREKYKSSK 108
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 275-379 2.57e-13

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 67.56  E-value: 2.57e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 275 ESRSTNTHRMFEFQSGLNTSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRAN-LQLLGISAMVICSRLL 353
Cdd:cd20580   22 ESKYVHDKHFLQLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKNINKSmLQLIGITSLFIASKLE 101

                         90       100
                 ....*....|....*....|....*.
gi 585707535 354 EKDIVTIREAAWLTDGTYSYEEVVRM 379
Cdd:cd20580  102 EIYPPKLHEFAYVTDGACSEDDILDM 127
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 295-387 1.38e-12

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 63.89  E-value: 1.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 295 MRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSRLLEKDIVTIREAAWLTDGTYSYE 374
Cdd:cd20536    1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTRE 80

                         90
                 ....*....|...
gi 585707535 375 EVVRMMGEIVAVL 387
Cdd:cd20536   81 QICNLECIILTKL 93
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 294-387 1.41e-12

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 65.28  E-value: 1.41e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 294 SMRYILVDWLVEVtGMKdFSNL--TLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSRLLEKDIVTIREAAWLTDGTY 371
Cdd:cd20565   34 NMRAILIDWLVQV-QMK-FRLLqeTMYMTVAIIDRFLQNNPVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTY 111

                         90
                 ....*....|....*.
gi 585707535 372 SYEEVVRMMGEIVAVL 387
Cdd:cd20565  112 TKHQIRQMEMKILRAL 127
CYCLIN_AtCycB-like_rpt2 cd20511
second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 394-515 8.79e-11

second cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410215  Cd Length: 117  Bit Score: 59.63  E-value: 8.79e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 394 PTVLDYLHLFCDLAAVDKQTECLAMFITEMTLLHVEFGLFTVANLAASAVFLARVLLLQDFPWPNHMVDFTFFTVDDITP 473
Cdd:cd20511    1 PTPYVFLVRFLKAAQSDKKLENLAFFLVELGLVEYEMLKYSPSMLAASAVYTARCTLNKTPEWTSTLEFHTGYSESQLME 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 585707535 474 CALLLFRKcfvepsltdHRDV---TLMAVKQRYSEENRLEVAKIE 515
Cdd:cd20511   81 CARLMVRL---------HSKAgtgKLTAVYKKYSSSKFGAVALLP 116
CYCLIN_AtCycA-like_rpt2 cd20506
second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 394-504 1.66e-10

second cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410210  Cd Length: 111  Bit Score: 58.80  E-value: 1.66e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 394 PTVLDYLHLF---CDLAAVDKQTECLAMFITEMTLLHVEFGLFTVANLAASAVFLARVLLLQDfPWPNHMVDFTFFTVDD 470
Cdd:cd20506    1 PTIKTFLRRFlraAQASVPDLKLEFLANYLAELSLLDYEFLKYLPSLIAASAVFLARHTLNPH-PWNPTLEHYTGYKAAD 79

                         90       100       110
                 ....*....|....*....|....*....|....
gi 585707535 471 ITPCALLLFRkCFVEPSLTdhrdvTLMAVKQRYS 504
Cdd:cd20506   80 LKPCVQALHD-LQLNASGS-----SLQAVREKYK 107
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 301-384 2.40e-10

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 57.22  E-value: 2.40e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535   301 DWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSRLLEKDiVTIREAAWLTdGTYSYEEVVRMM 380
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETP-PWTKELVHYT-GYFTEEEILRME 78


                   ....
gi 585707535   381 GEIV 384
Cdd:smart00385  79 RLLL 82
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 398-480 1.05e-09

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 55.68  E-value: 1.05e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535   398 DYLHLFCDLAAVDKQTECLAMFITEMTLLHVEFGLFTVANLAASAVFLARvLLLQDFPWPNHMVDFT-FFTVDDITPCAL 476
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLAS-KTEETPPWTKELVHYTgYFTEEEILRMER 79


                   ....
gi 585707535   477 LLFR 480
Cdd:smart00385  80 LLLE 83
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 283-379 1.31e-09

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 56.81  E-value: 1.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 283 RMFEFQSGLNTSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTT-RANLQLLGISAMVICSRLLEKDIVTIR 361
Cdd:cd20579   30 NFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQENVvKTRLQLIGISSLFIAAKLEEIYPPKLH 109

                         90
                 ....*....|....*...
gi 585707535 362 EAAWLTDGTYSYEEVVRM 379
Cdd:cd20579  110 QFAYVTDGACTEDEILSM 127
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 280-379 5.32e-09

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 55.38  E-value: 5.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 280 NTHRMFEFQSGLNTSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSRLLEKDIVT 359
Cdd:cd20515   40 SASYFKCVQTEIQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPIRKSQLQLLGAVCLFLASKLKETIPLT 119

                         90       100
                 ....*....|....*....|
gi 585707535 360 IREAAWLTDGTYSYEEVVRM 379
Cdd:cd20515  120 AEKLCIYTDNSITLQELLDW 139
CYCLIN_CCNB3_rpt2 cd20510
second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 ...
 399-514 1.17e-08

second cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410214  Cd Length: 115  Bit Score: 53.44  E-value: 1.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 399 YLHLFCDLAAVDKQTECLAMFITEMTLLHVEFGLFTVANLAASAVFLArVLLLQDFPWPNHMVDFTFFTVDDITPCALLL 478
Cdd:cd20510    6 FLRRYAKCARASMETLTLARYILELSLMEYQFVQERASKLAAAALLLA-LKMKNLGEWTPTLEYYSGYSAEDLLPLVRKL 84

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 585707535 479 frkcfvEPSLTDHRDVTLMAVKQRYSEENRLEVAKI 514
Cdd:cd20510   85 ------NAMLTKPPNKKLKTVRSKYSHKVFFEVAKI 114
CYCLIN_CCNA1_rpt2 cd20563
second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily ...
 394-515 1.80e-08

second cyclin box found in cyclin-A1 (CCNA1) and similar proteins; CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410266  Cd Length: 123  Bit Score: 53.28  E-value: 1.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 394 PTVLDYLHLFCDLAAVDKQTECLAMFITEMTLLHVE-FGLFTVANLAASAVFLARVLLLQDFpWPNHMVDFTFFTVDDIT 472
Cdd:cd20563    1 PTINQFLLQYLKRHEVCEKTENLAMYVAELSLLEVDpFLKYLPSLTAAAAYCLANYTVNKVF-WPETLAAFTGYSLSEIV 79

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 585707535 473 PCALLLFRKCFVEPsltdHRdvTLMAVKQRYSEENRLEVAKIE 515
Cdd:cd20563   80 PCLSDLHKACLGAP----HR--PQQAIREKYKGSKYMQVSLLE 116
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 269-379 1.62e-07

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 51.13  E-value: 1.62e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 269 VFQFVLESRSTNTHRMFEF---QSGLNTSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISA 345
Cdd:cd20573   25 VLQTMLKAEETCLPSVSYFkcvQKEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGATC 104

                         90       100       110
                 ....*....|....*....|....*....|....
gi 585707535 346 MVICSRLLEKDIVTIREAAWLTDGTYSYEEVVRM 379
Cdd:cd20573  105 MFLASKMKETIPLTAEKLCIYTDNSIRPEELLQM 138
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 274-376 1.66e-07

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 51.14  E-value: 1.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 274 LESRSTNTHRMFE-FQSGLNTSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSRL 352
Cdd:cd20575   33 LEERYVPRVSYFQcVQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQLLGAVCMLLASKL 112

                         90       100
                 ....*....|....*....|....
gi 585707535 353 LEKDIVTIREAAWLTDGTYSYEEV 376
Cdd:cd20575  113 RETTPLTIEKLCIYTDNSISPRQL 136
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 299-380 2.70e-06

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 45.86  E-value: 2.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 299 LVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSRLLEKDIvTIREAAWLTDgtYSYEEVVR 378
Cdd:cd00043    2 AVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACKLEELPR-TLKEIAKVSG--VSEKELRK 78


                 ..
gi 585707535 379 MM 380
Cdd:cd00043   79 AE 80
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 299-387 6.64e-06

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 45.07  E-value: 6.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 299 LVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSRLLEKD--IVTIREAAWLTDGTYSYEEV 376
Cdd:cd20559    2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKarVPLLSELSKMCCNSYGEELF 81

                         90
                 ....*....|.
gi 585707535 377 VRMMGEIVAVL 387
Cdd:cd20559   82 IQMEMHILNTL 92
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 288-377 7.68e-06

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 46.52  E-value: 7.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 288 QSGLNTSMRYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYLMLQPTTRANLQLLGISAMVICSRLLEKDIVTIREAAWLT 367
Cdd:cd20574   48 QKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTRKCHLQLLGAVCMFLASKLKETIPLTAEKLCIYT 127

                         90
                 ....*....|
gi 585707535 368 DGTYSYEEVV 377
Cdd:cd20574  128 DNSIKPQELL 137
CYCLIN_CCNA2_rpt2 cd20564
second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1 ...
 394-480 1.13e-05

second cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly overexpressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410267  Cd Length: 110  Bit Score: 44.82  E-value: 1.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 394 PTVLDYLHLFCDLAAVDKQTECLAMFITEMTLLHVEFGLFTVANLAASAVFLARVLLLQDFPWPNHMVDFTFFTVDDITP 473
Cdd:cd20564    1 PTINQFLTQYFLHQQANCKVESLSMFLGELSLIDADPYLKYLPSVIAAAAFHLALYTVTGQSWPESLVQKTGYTLESLKP 80


                 ....*..
gi 585707535 474 CALLLFR 480
Cdd:cd20564   81 CLMDLHQ 87
FBOX smart00256
A Receptor for Ubiquitination Targets;
23-61 2.00e-05

A Receptor for Ubiquitination Targets;


Pssm-ID: 197608  Cd Length: 41  Bit Score: 42.04  E-value: 2.00e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 585707535    23 LPEEVLVLLVKGLPAKDLLSMRAVHSKFRNIIDtNPSIW 61
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLID-SHDFW 38
CYCLIN_CLBs_yeast_rpt2 cd20512
second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae ...
 410-512 3.95e-05

second cyclin box found in yeast B-type cyclins; The family includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transition. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410216  Cd Length: 116  Bit Score: 43.37  E-value: 3.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 410 DKQTECLAMFITEMTLLHVEFGLFTVANLAASAVFLARVLLLQDfPWPNHMVDFTFFTVDDITPCALLLFrKCFVEPSlt 489
Cdd:cd20512   16 DIQTRTLAKYLLEITILDHRFLGYPPSLLAAAAMYLARKMLGRG-DWNDNLVHYSGYTESQLIPCADIML-EYLVKPI-- 91

                         90       100
                 ....*....|....*....|...
gi 585707535 490 DHRDvtlmAVKQRYSEENRLEVA 512
Cdd:cd20512   92 KHHD----AFFKKYSSKKFLKAS 110
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 394-478 3.86e-04

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 40.43  E-value: 3.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 585707535 394 PTVLDYLHLFCDLAAVDKQT------ECLAM----------FITEMTLLHVEFGLFTVANLAASAVFLARVLLLQDFPWP 457
Cdd:cd20529    1 PTPAHFLEYYLSQGVLFVDDhdglpsELLEKvkeyvrkyadFFLDLSLQDYAFLNYKPSLLAAACIAAARKALGLSPTWP 80

                         90       100
                 ....*....|....*....|.
gi 585707535 458 NHMVDFTFFTVDDITPCALLL 478
Cdd:cd20529   81 EELEKLTGYSEDELEPCVELL 101
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 20-64 1.21e-03

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 37.08  E-value: 1.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 585707535   20 VWCLPEEVLVLLVKGLPAKDLLSMRAVHSKFRNIIDtNPSIWSTV 64
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELAS-DDSLWRRL 44
F-box_CeFBXA-like cd22150
F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and ...
 23-56 2.43e-03

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438921  Cd Length: 46  Bit Score: 36.31  E-value: 2.43e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 585707535  23 LPEEVLVLLVKGLPAKDLLSMRAVHSKFRNIIDT 56
Cdd:cd22150    4 LPIEILNKILDKLDPIDRLVLRKVSRNLRDIVDN 37
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 22-63 3.27e-03

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 35.98  E-value: 3.27e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 585707535   22 CLPEEVLVLLVKGLPAKDLLSMRAVHSKFRNIIDtNPSIWST 63
Cdd:pfam00646   3 DLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVD-SLKLWKK 43
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 296-357 5.88e-03

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 36.91  E-value: 5.88e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 585707535 296 RYILVDWLVEVTGMKDFSNLTLHTAVRCIDRYL--MLQPTTRAN-LQLLGISAMVICSRLLEKDI 357
Cdd:cd20543    2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLssYDLPKDKPWmLQLLAVACLSLAAKMEETDV 66
F-box_FBXO31 cd22102
F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called ...
 23-61 8.34e-03

F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called FBX31, or FBXO14, is a component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438874  Cd Length: 48  Bit Score: 35.10  E-value: 8.34e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 585707535  23 LPEEVLVLLVKGLPAKDLLSMRAVHSKFRNIIDTNpSIW 61
Cdd:cd22102    4 LPPELLVEIFSSLPGTDLPSLAQVCKKFREILNTD-TIW 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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