|
Name |
Accession |
Description |
Interval |
E-value |
| PUFD_like_1 |
cd14260 |
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger ... |
1666-1779 |
9.63e-68 |
|
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats.
Pssm-ID: 271223 Cd Length: 115 Bit Score: 223.57 E-value: 9.63e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1666 EEDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAER 1745
Cdd:cd14260 2 EEDDFMFEFSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEIATMPKAEFYRQVLSSQLLTPAER 81
|
90 100 110
....*....|....*....|....*....|....
gi 578838729 1746 PGGLDDRSPPGSSETVELVRYEPDLLRLLGSEVE 1779
Cdd:cd14260 82 PGGLDDRSPQGSSETVELVRYEPELLRLLGSAVE 115
|
|
| PUFD |
pfam16553 |
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 ... |
1667-1781 |
3.41e-61 |
|
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 corepressor) that is needed for binding and giving specificity to some of the PCGF proteins, polycomb-group RING finger homologs. PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF PCGF1, pfam16207. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologs whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health.
Pssm-ID: 465171 Cd Length: 114 Bit Score: 204.92 E-value: 3.41e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1667 EDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAERP 1746
Cdd:pfam16553 1 SDVFEFEFSDKPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRARFPHFEVVTIAEAEFYKQVSLSQLLSPPEDL 80
|
90 100 110
....*....|....*....|....*....|....*
gi 578838729 1747 GGlddrSPPGSSETVELVRYEPDLLRLLGSEVEFQ 1781
Cdd:pfam16553 81 EA----FNPDSKELVELVEFTPELQTLLGSSVEFL 111
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1494-1603 |
1.55e-27 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 114.67 E-value: 1.55e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1494 NAGETLLQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVN 1573
Cdd:COG0666 118 KDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEN 196
|
90 100 110
....*....|....*....|....*....|
gi 578838729 1574 DNLETIWLLLSYGADPTLATYSGQTAMKLA 1603
Cdd:COG0666 197 GHLEIVKLLLEAGADVNAKDNDGKTALDLA 226
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1500-1591 |
1.83e-16 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 76.31 E-value: 1.83e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1500 LQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHgANVNCSAQDGTrPVHDAVVNDNLETI 1579
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRT-ALHYAARSGHLEIV 77
|
90
....*....|..
gi 578838729 1580 WLLLSYGADPTL 1591
Cdd:pfam12796 78 KLLLEKGADINV 89
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
198-636 |
5.42e-16 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 84.60 E-value: 5.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 198 PLPAPIcPPAPGSASVPHSvPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPA-------------LAPAPPS 264
Cdd:PHA03247 2571 PRPAPR-PSEPAVTSRARR-PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPpspspaanepdphPPPTVPP 2648
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 265 VPTLISDSNPLSVS-----ASVLVPVPASAPPSGPVPLSAPAP-APLSVPVSAPPlaliQAPVPPSAPTLVLAPVPTPvl 338
Cdd:PHA03247 2649 PERPRDDPAPGRVSrprraRRLGRAAQASSPPQRPRRRAARPTvGSLTSLADPPP----PPPTPEPAPHALVSATPLP-- 2722
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 339 apmpastPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAiPTSAPIPASFSLS 418
Cdd:PHA03247 2723 -------PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASLSES 2794
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 419 RVCFPAAQAPAMQKVPLSFQPGTVLTPSQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYLQDRCLP--GVLAS 496
Cdd:PHA03247 2795 RESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPsrSPAAK 2874
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 497 PELRSYPYAFSVARPLTSDSKlvslevnrLPCTSPSGSTTTQPAPDGVPGPLAdtslvTASAKVLPTPQPLLPAPSGSSA 576
Cdd:PHA03247 2875 PAAPARPPVRRLARPAVSRST--------ESFALPPDQPERPPQPQAPPPPQP-----QPQPPPPPQPQPPPPPPPRPQP 2941
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578838729 577 PPHPAKMPSGTEQQTEGTSVTFSPLKSPPQLE--REMASPPECSeMPLDLSSKSNRQKLPLP 636
Cdd:PHA03247 2942 PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvpRFRVPQPAPS-REAPASSTPPLTGHSLS 3002
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1497-1588 |
4.25e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 63.92 E-value: 4.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1497 ETLLQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNL 1576
Cdd:PHA03100 160 KLLIDKGVDINAKNRVNYLLSYGV-PINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
|
90
....*....|..
gi 578838729 1577 ETIWLLLSYGAD 1588
Cdd:PHA03100 239 EIFKLLLNNGPS 250
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
218-664 |
2.48e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 55.93 E-value: 2.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 218 PDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLSVSASVLVPVPASAP-PSGPVP 296
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPsPHPPLQ 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 297 LSAPAPAPLSVPVSAPPLALIQAPVPP------SAPTLVLAPVPTpvlapMPASTPPAAPAPPSVPMPTPTPSSGPPSTP 370
Cdd:pfam03154 251 PMTQPPPPSQVSPQPLPQPSLHGQMPPmphslqTGPSHMQHPVPP-----QPFPLTPQSSQSQVPPGPSPAAPGQSQQRI 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 371 TLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPaaiPTSAPIPAsfslsrvcFPAAQA---PAMQKVPLSFQPGTVLtpsq 447
Cdd:pfam03154 326 HTPPSQSQLQSQQPPREQPLPPAPLSMPHIKP---PPTTPIPQ--------LPNPQShkhPPHLSGPSPFQMNSNL---- 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 448 plvyiPPPSCGQPLSvaTLPTTLGVSStlTLPVLPSYLQDRCLPGVLASPelrsypyafsvarPLTSDSKLVSLEVNRLP 527
Cdd:pfam03154 391 -----PPPPALKPLS--SLSTHHPPSA--HPPPLQLMPQSQQLPPPPAQP-------------PVLTQSQSLPPPAASHP 448
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 528 CTSPSGSTTTQP-------APDGVPGPLADTSLVTASAKVLPTPQPLLPAPSGSSAPphpakMPSGTEQQTEGTSVTFSP 600
Cdd:pfam03154 449 PTSGLHQVPSQSpfpqhpfVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGP-----VPAAVSCPLPPVQIKEEA 523
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578838729 601 LKSPPQLEremaSPPecsempldlssksnrqklPLPNQRKTPPMPVLTPVHTSSKALLSTVLSR 664
Cdd:pfam03154 524 LDEAEEPE----SPP------------------PPPRSPSPEPTVVNTPSHASQSARFYKHLDR 565
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
1530-1558 |
7.17e-06 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 44.12 E-value: 7.17e-06
10 20
....*....|....*....|....*....
gi 578838729 1530 GYTALHEACSRGWTDILNILLEHGANVNC 1558
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
1489-1588 |
1.13e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 43.85 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1489 LIVNKNAGETLLQRAARLGYKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHG---ANVNCSAQ--DG 1563
Cdd:cd22192 10 LLQQKRISESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelVNEPMTSDlyQG 89
|
90 100
....*....|....*....|....*
gi 578838729 1564 TRPVHDAVVNDNLETIWLLLSYGAD 1588
Cdd:cd22192 90 ETALHIAVVNQNLNLVRELIARGAD 114
|
|
| rad23 |
TIGR00601 |
UV excision repair protein Rad23; All proteins in this family for which functions are known ... |
272-337 |
8.12e-03 |
|
UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273167 [Multi-domain] Cd Length: 378 Bit Score: 40.65 E-value: 8.12e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578838729 272 SNPLSVSASVlvPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTlvlAPVPTPV 337
Cdd:TIGR00601 75 SKPKTGTGKV--APPAATPTSAPTPTPSPPASPASGMSAAPASAVEEKSPSEESAT---ATAPESP 135
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PUFD_like_1 |
cd14260 |
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger ... |
1666-1779 |
9.63e-68 |
|
PCGF Ub-like fold discriminator of BCOR-like 1; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor-like protein 1 (BCoR-L1) is largely uncharacterized; it contains ankyrin repeats.
Pssm-ID: 271223 Cd Length: 115 Bit Score: 223.57 E-value: 9.63e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1666 EEDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAER 1745
Cdd:cd14260 2 EEDDFMFEFSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEIATMPKAEFYRQVLSSQLLTPAER 81
|
90 100 110
....*....|....*....|....*....|....
gi 578838729 1746 PGGLDDRSPPGSSETVELVRYEPDLLRLLGSEVE 1779
Cdd:cd14260 82 PGGLDDRSPQGSSETVELVRYEPELLRLLGSAVE 115
|
|
| PUFD |
pfam16553 |
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 ... |
1667-1781 |
3.41e-61 |
|
BCORL-PCGF1-binding domain; PUFD is the minimal domain at the C-terminus of BCORL (BCL6 corepressor) that is needed for binding and giving specificity to some of the PCGF proteins, polycomb-group RING finger homologs. PUFD binds to the RAWUL (RING finger- and WD40-associated ubiquitin-like) domain of the particular PCGF PCGF1, pfam16207. Polycomb group proteins form repressive complexes (PRC) that mediate epigenetic modifications of histones. In humans there are many different PCGF homologs whose functions all vary, but the direct binding partner of PCGF1 is BCOR. BCOR has emerged as an important player in development and health.
Pssm-ID: 465171 Cd Length: 114 Bit Score: 204.92 E-value: 3.41e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1667 EDDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAERP 1746
Cdd:pfam16553 1 SDVFEFEFSDKPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRARFPHFEVVTIAEAEFYKQVSLSQLLSPPEDL 80
|
90 100 110
....*....|....*....|....*....|....*
gi 578838729 1747 GGlddrSPPGSSETVELVRYEPDLLRLLGSEVEFQ 1781
Cdd:pfam16553 81 EA----FNPDSKELVELVEFTPELQTLLGSSVEFL 111
|
|
| PUFD_like |
cd14259 |
PCGF Ub-like fold discriminator and related domains; The PUFD domain binds the RAWUL (RING ... |
1668-1779 |
9.24e-43 |
|
PCGF Ub-like fold discriminator and related domains; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis.
Pssm-ID: 271222 Cd Length: 106 Bit Score: 151.70 E-value: 9.24e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1668 DDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAERPg 1747
Cdd:cd14259 1 DDFEFEFSDEPLPPLYNLRISPNDGPRNWHLLSDVLTRLKLKSRDFLLKQICLELTSIPIEDFLEQASCLQLLCAGEKL- 79
|
90 100 110
....*....|....*....|....*....|..
gi 578838729 1748 glddrSPPGSSETVELVRYEPDLLRLLGSEVE 1779
Cdd:cd14259 80 -----TNNVSSSKVELVEYNDSLRSLLGIEVE 106
|
|
| PUFD |
cd14261 |
PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and ... |
1668-1779 |
1.11e-36 |
|
PCGF Ub-like fold discriminator of BCOR; The PUFD domain binds the RAWUL (RING finger and WD40-associated ubiquitin-like) domain of the polycomb-group RING finger homologs PCGF1 and PCGF3. PUFD was characterized as a domain of the BCL6 corepressor BCOR. It does not appear to bind to PCGF2 and PCGF4. PCGF1 is a component of the Polycomb group (PcG) multi-protein BCOR complex, which is involved in repressing the transcription of BCL6 and CDKN1A. The BCL-6 corepressor (BCOR) is a transcriptional repressor required for germinal center formation and is possibly involved in apoptosis.
Pssm-ID: 271224 Cd Length: 117 Bit Score: 134.97 E-value: 1.11e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1668 DDFMFELSDKPLLPCYNLQVSVSRGPCNWFLFSDVLKRLKLSSRIFQARFPHFEITTMPKAEFYRQVASSQLLTPAERPG 1747
Cdd:cd14261 6 DVFEFEFSDRPLLPCYNIQVSLSQGPRNWLLLSDVLKRLKMSSRIFRCNFPNVEVVTIAEAEFYRQVSLSQLFSCPKDLE 85
|
90 100 110
....*....|....*....|....*....|..
gi 578838729 1748 GLDdrspPGSSETVELVRYEPDLLRLLGSEVE 1779
Cdd:cd14261 86 AFN----PDSKELLDLVEFTNELQTLLGSSLE 113
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1494-1603 |
1.55e-27 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 114.67 E-value: 1.55e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1494 NAGETLLQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVN 1573
Cdd:COG0666 118 KDGETPLHLAAYNGNLEIVKLLLEAGA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAEN 196
|
90 100 110
....*....|....*....|....*....|
gi 578838729 1574 DNLETIWLLLSYGADPTLATYSGQTAMKLA 1603
Cdd:COG0666 197 GHLEIVKLLLEAGADVNAKDNDGKTALDLA 226
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1489-1605 |
3.21e-25 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 107.73 E-value: 3.21e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1489 LIVNKNAGETLLQRAARLGYKDVVLYCLQKDsEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVH 1568
Cdd:COG0666 80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLH 158
|
90 100 110
....*....|....*....|....*....|....*..
gi 578838729 1569 DAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASS 1605
Cdd:COG0666 159 LAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAE 195
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1484-1603 |
1.07e-19 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 91.55 E-value: 1.07e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1484 PEARRLIVNKNA--------GETLLQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGAN 1555
Cdd:COG0666 133 LEIVKLLLEAGAdvnaqdndGNTPLHLAAANGNLEIVKLLLEAGA-DVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 578838729 1556 VNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLA 1603
Cdd:COG0666 212 VNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLA 259
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1489-1603 |
8.33e-17 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 83.08 E-value: 8.33e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1489 LIVNKNAGETLLQRAARLGYKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVH 1568
Cdd:COG0666 46 ALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLH 125
|
90 100 110
....*....|....*....|....*....|....*
gi 578838729 1569 DAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLA 1603
Cdd:COG0666 126 LAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1500-1591 |
1.83e-16 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 76.31 E-value: 1.83e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1500 LQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHgANVNCSAQDGTrPVHDAVVNDNLETI 1579
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGA-DANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRT-ALHYAARSGHLEIV 77
|
90
....*....|..
gi 578838729 1580 WLLLSYGADPTL 1591
Cdd:pfam12796 78 KLLLEKGADINV 89
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
198-636 |
5.42e-16 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 84.60 E-value: 5.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 198 PLPAPIcPPAPGSASVPHSvPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPA-------------LAPAPPS 264
Cdd:PHA03247 2571 PRPAPR-PSEPAVTSRARR-PDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPpspspaanepdphPPPTVPP 2648
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 265 VPTLISDSNPLSVS-----ASVLVPVPASAPPSGPVPLSAPAP-APLSVPVSAPPlaliQAPVPPSAPTLVLAPVPTPvl 338
Cdd:PHA03247 2649 PERPRDDPAPGRVSrprraRRLGRAAQASSPPQRPRRRAARPTvGSLTSLADPPP----PPPTPEPAPHALVSATPLP-- 2722
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 339 apmpastPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAAiPTSAPIPASFSLS 418
Cdd:PHA03247 2723 -------PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASLSES 2794
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 419 RVCFPAAQAPAMQKVPLSFQPGTVLTPSQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYLQDRCLP--GVLAS 496
Cdd:PHA03247 2795 RESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPsrSPAAK 2874
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 497 PELRSYPYAFSVARPLTSDSKlvslevnrLPCTSPSGSTTTQPAPDGVPGPLAdtslvTASAKVLPTPQPLLPAPSGSSA 576
Cdd:PHA03247 2875 PAAPARPPVRRLARPAVSRST--------ESFALPPDQPERPPQPQAPPPPQP-----QPQPPPPPQPQPPPPPPPRPQP 2941
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578838729 577 PPHPAKMPSGTEQQTEGTSVTFSPLKSPPQLE--REMASPPECSeMPLDLSSKSNRQKLPLP 636
Cdd:PHA03247 2942 PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvpRFRVPQPAPS-REAPASSTPPLTGHSLS 3002
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1494-1600 |
5.37e-12 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 68.44 E-value: 5.37e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1494 NAGETLLQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVN 1573
Cdd:COG0666 184 NDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAA 262
|
90 100
....*....|....*....|....*..
gi 578838729 1574 DNLETIWLLLSYGADPTLATYSGQTAM 1600
Cdd:COG0666 263 GAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1491-1557 |
3.41e-10 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 58.20 E-value: 3.41e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578838729 1491 VNKNAGETLLQRAARLGYKDVVLYCLQKdsEDVNHRDNaGYTALHEACSRGWTDILNILLEHGANVN 1557
Cdd:pfam12796 25 LQDKNGRTALHLAAKNGHLEIVKLLLEH--ADVNLKDN-GRTALHYAARSGHLEIVKLLLEKGADIN 88
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1497-1588 |
4.25e-10 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 63.92 E-value: 4.25e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1497 ETLLQRAARLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNL 1576
Cdd:PHA03100 160 KLLIDKGVDINAKNRVNYLLSYGV-PINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNK 238
|
90
....*....|..
gi 578838729 1577 ETIWLLLSYGAD 1588
Cdd:PHA03100 239 EIFKLLLNNGPS 250
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1534-1605 |
5.45e-09 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 54.74 E-value: 5.45e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578838729 1534 LHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGAdpTLATYSGQTAMKLASS 1605
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAAR 70
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1484-1603 |
5.75e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 57.37 E-value: 5.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1484 PEARRLIVNKNA--------GETLLQRAA--RLGYKDVVLYCLQKDSeDVNHRDNAGYTALHEA--CSRGWTDILNILLE 1551
Cdd:PHA03100 86 KEIVKLLLEYGAnvnapdnnGITPLLYAIskKSNSYSIVEYLLDNGA-NVNIKNSDGENLLHLYleSNKIDLKILKLLID 164
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1552 HGANVNcsAQD------------------GTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLA 1603
Cdd:PHA03100 165 KGVDIN--AKNrvnyllsygvpinikdvyGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIA 232
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
181-609 |
1.53e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 56.87 E-value: 1.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 181 TGVPVEGTLPLVTTNFSPLP-APICPPAPGSASVPHSVPDAFQVPLSVPAPVPHSGLVPvqvatsvPAPSPPLAPVPALA 259
Cdd:PHA03247 2717 SATPLPPGPAAARQASPALPaAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAP-------AAGPPRRLTRPAVA 2789
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 260 PAPPSVPTLISDSNPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPlaliqAPVPPSAPTLVLAPVPTPVLA 339
Cdd:PHA03247 2790 SLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP-----GPPPPSLPLGGSVAPGGDVRR 2864
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 340 PMPASTPPAapappsvpmptptpssgppstptlipafaptpvpaptpapifTPAPTPMPAATPAAIPTSAPIPASFSLSR 419
Cdd:PHA03247 2865 RPPSRSPAA------------------------------------------KPAAPARPPVRRLARPAVSRSTESFALPP 2902
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 420 VCFPAAQAPAMQKVPLSFQPgtvlTPSQPLVYIPPPSCGQPLSVATlPTTLGVSSTLTLPVLPSYLQDRCLPGVLASPEL 499
Cdd:PHA03247 2903 DQPERPPQPQAPPPPQPQPQ----PPPPPQPQPPPPPPPRPQPPLA-PTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRF 2977
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 500 RSYPYAFSVARPLTSDSKLVSLEVNRL------------PCTSPSGSTTTQPAPDGVPGPLADTSLVTASAKV-LPTPQP 566
Cdd:PHA03247 2978 RVPQPAPSREAPASSTPPLTGHSLSRVsswasslalheeTDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSdLEALDP 3057
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 578838729 567 LLPAPSGSSAPPHPAKMPSGTEQQTEGTSVTFSPLKSPPQLER 609
Cdd:PHA03247 3058 LPPEPHDPFAHEPDPATPEAGARESPSSQFGPPPLSANAALSR 3100
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
205-419 |
2.00e-07 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 56.04 E-value: 2.00e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 205 PPAPGSASVPHSVPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSvptlisdsnPLSVSASVLVP 284
Cdd:PRK12323 374 PATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEAL---------AAARQASARGP 444
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 285 VPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAptlvlAPVPTPVLAPMPASTPPAAPAPPSVPMPTPTPSS 364
Cdd:PRK12323 445 GGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAP-----AAAPAPADDDPPPWEELPPEFASPAPAQPDAAPA 519
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 578838729 365 GPPSTPTLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPAaiPTSAPIPASFSLSR 419
Cdd:PRK12323 520 GWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATE--PVVAPRPPRASASG 572
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
218-664 |
2.48e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 55.93 E-value: 2.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 218 PDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLSVSASVLVPVPASAP-PSGPVP 296
Cdd:pfam03154 171 PPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPsPHPPLQ 250
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 297 LSAPAPAPLSVPVSAPPLALIQAPVPP------SAPTLVLAPVPTpvlapMPASTPPAAPAPPSVPMPTPTPSSGPPSTP 370
Cdd:pfam03154 251 PMTQPPPPSQVSPQPLPQPSLHGQMPPmphslqTGPSHMQHPVPP-----QPFPLTPQSSQSQVPPGPSPAAPGQSQQRI 325
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 371 TLIPAFAPTPVPAPTPAPIFTPAPTPMPAATPaaiPTSAPIPAsfslsrvcFPAAQA---PAMQKVPLSFQPGTVLtpsq 447
Cdd:pfam03154 326 HTPPSQSQLQSQQPPREQPLPPAPLSMPHIKP---PPTTPIPQ--------LPNPQShkhPPHLSGPSPFQMNSNL---- 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 448 plvyiPPPSCGQPLSvaTLPTTLGVSStlTLPVLPSYLQDRCLPGVLASPelrsypyafsvarPLTSDSKLVSLEVNRLP 527
Cdd:pfam03154 391 -----PPPPALKPLS--SLSTHHPPSA--HPPPLQLMPQSQQLPPPPAQP-------------PVLTQSQSLPPPAASHP 448
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 528 CTSPSGSTTTQP-------APDGVPGPLADTSLVTASAKVLPTPQPLLPAPSGSSAPphpakMPSGTEQQTEGTSVTFSP 600
Cdd:pfam03154 449 PTSGLHQVPSQSpfpqhpfVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGP-----VPAAVSCPLPPVQIKEEA 523
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578838729 601 LKSPPQLEremaSPPecsempldlssksnrqklPLPNQRKTPPMPVLTPVHTSSKALLSTVLSR 664
Cdd:pfam03154 524 LDEAEEPE----SPP------------------PPPRSPSPEPTVVNTPSHASQSARFYKHLDR 565
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1485-1613 |
2.91e-07 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 54.19 E-value: 2.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1485 EARRLIVNKNAGETLLQRAARLGYKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGT 1564
Cdd:COG0666 9 LLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGN 88
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 578838729 1565 RPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASS----DTMKRFLS 1613
Cdd:COG0666 89 TLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYngnlEIVKLLLE 141
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
1530-1582 |
1.10e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 47.27 E-value: 1.10e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 578838729 1530 GYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETI-WLL 1582
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLkLLL 54
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1522-1599 |
1.14e-06 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 53.10 E-value: 1.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1522 DVNHRDNAGYTALHeACSRGW---TDILNILLEHGANVNCSAQDGTRPVHDAVVNDN--LETIWLLLSYGADPTLATYSG 1596
Cdd:PHA03095 109 DVNAKDKVGRTPLH-VYLSGFninPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNanVELLRLLIDAGADVYAVDDRF 187
|
...
gi 578838729 1597 QTA 1599
Cdd:PHA03095 188 RSL 190
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
1477-1588 |
1.23e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 53.53 E-value: 1.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1477 PTARQIPPEARRLIVNKNA----GETLLQRAARLGYKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRG-WTDILNILLE 1551
Cdd:PHA02876 284 PSLSRLVPKLLERGADVNAknikGETPLYLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLE 363
|
90 100 110
....*....|....*....|....*....|....*..
gi 578838729 1552 HGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGAD 1588
Cdd:PHA02876 364 LGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD 400
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
1548-1627 |
1.40e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 53.36 E-value: 1.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1548 ILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASS----DTMKRFLSDHLSDLQGRA 1623
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEEngfrEVVQLLSRHSQCHFELGA 179
|
....
gi 578838729 1624 EGDP 1627
Cdd:PTZ00322 180 NAKP 183
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
1522-1600 |
2.61e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 51.89 E-value: 2.61e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578838729 1522 DVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAM 1600
Cdd:PHA02874 116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPL 194
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1531-1619 |
2.63e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 51.97 E-value: 2.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1531 YTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVH-----DAVVNDNLETIWLLLSYGADPTLATYSGQT-----AM 1600
Cdd:PHA03100 36 VLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHylsniKYNLTDVKEIVKLLLEYGANVNAPDNNGITpllyaIS 115
|
90
....*....|....*....
gi 578838729 1601 KLASSDTMKRFLSDHLSDL 1619
Cdd:PHA03100 116 KKSNSYSIVEYLLDNGANV 134
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
1508-1603 |
3.10e-06 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 51.80 E-value: 3.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1508 YKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWT-DILNILLEHGANVNC-SAQDGTRPVHDAVVNDnlETIWLLLSY 1585
Cdd:PHA02878 212 YNKPIVHILLENGASTDARDKCGNTPLHISVGYCKDyDILKLLLEHGVDVNAkSYILGLTALHSSIKSE--RKLKLLLEY 289
|
90
....*....|....*...
gi 578838729 1586 GADPTLATYSGQTAMKLA 1603
Cdd:PHA02878 290 GADINSLNSYKLTPLSSA 307
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
1498-1550 |
3.30e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 45.73 E-value: 3.30e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 578838729 1498 TLLQRAARLGYKDVVLYCLQKdSEDVNHRDNAGYTALHEACSRGWTDILNILL 1550
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
1516-1568 |
5.90e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 45.03 E-value: 5.90e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 578838729 1516 LQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVH 1568
Cdd:pfam13857 2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1516-1588 |
6.74e-06 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 50.79 E-value: 6.74e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578838729 1516 LQKDSEDVNHRDNAGYTALHEACSRGW---TDILNILLEHGANVNCSAQDGTRPVHDAVVNDN-LETIWLLLSYGAD 1588
Cdd:PHA03095 33 LLAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGAD 109
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
1530-1558 |
7.17e-06 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 44.12 E-value: 7.17e-06
10 20
....*....|....*....|....*....
gi 578838729 1530 GYTALHEACSRGWTDILNILLEHGANVNC 1558
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
287-649 |
7.72e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 51.09 E-value: 7.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 287 ASAPPSGPVPLSAPAPAPL----SVPVS-------------------APPL-ALIQAPV-PPSAPTLVLAPVPTPVLAPM 341
Cdd:PHA03247 2544 ASDDAGDPPPPLPPAAPPAapdrSVPPPrpaprpsepavtsrarrpdAPPQsARPRAPVdDRGDPRGPAPPSPLPPDTHA 2623
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 342 PASTPPAAPAPPSVPMPTPTPSSGPPSTPTLIPAfaptPVPAPTPAPIFTPAPTPMPAATPAAIPTSAPIPASFSLSRVC 421
Cdd:PHA03247 2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPA----PGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLA 2699
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 422 FPAAQAPAMQKVPLSFQPGTVLTP---SQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYlqdrclPGVLASPE 498
Cdd:PHA03247 2700 DPPPPPPTPEPAPHALVSATPLPPgpaAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAG------PPAPAPPA 2773
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 499 LRSYPYAFSVARPLTSdsklvSLEVNRLPCTSPSGSTttqPAPDGVPGPLADTSLVTASAKVLPTPQPLLPAPSGSSAPP 578
Cdd:PHA03247 2774 APAAGPPRRLTRPAVA-----SLSESRESLPSPWDPA---DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGP 2845
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578838729 579 HPAKMPSGTEQQTEGTSVTFSPLKSPPQLEREMASPPECSEMPLDLSSKSNRQKLPLPNQRKTPPMPVLTP 649
Cdd:PHA03247 2846 PPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPP 2916
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
1530-1558 |
4.59e-05 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 41.89 E-value: 4.59e-05
10 20 30
....*....|....*....|....*....|
gi 578838729 1530 GYTALHEACSR-GWTDILNILLEHGANVNC 1558
Cdd:pfam00023 2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNA 31
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
1522-1585 |
4.94e-05 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 48.36 E-value: 4.94e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578838729 1522 DVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSY 1585
Cdd:PTZ00322 107 DPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
1530-1558 |
1.12e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 40.70 E-value: 1.12e-04
10 20
....*....|....*....|....*....
gi 578838729 1530 GYTALHEACSRGWTDILNILLEHGANVNC 1558
Cdd:pfam13606 2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
1522-1605 |
1.48e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 46.41 E-value: 1.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1522 DVNHRD-NAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAM 1600
Cdd:PHA02878 159 DINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPL 238
|
....*
gi 578838729 1601 KLASS 1605
Cdd:PHA02878 239 HISVG 243
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
1516-1579 |
1.69e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 46.60 E-value: 1.69e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578838729 1516 LQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETI 1579
Cdd:PHA02876 164 LLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTI 227
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1490-1557 |
3.74e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 45.04 E-value: 3.74e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578838729 1490 IVNKNA-GETLLQRAARLGYKDVVLYCLQKdSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVN 1557
Cdd:PHA03100 185 INIKDVyGFTPLHYAVYNNNPEFVKYLLDL-GANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1522-1617 |
4.05e-04 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 45.02 E-value: 4.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1522 DVNHRDNAGYTALHEA---CSRGWTDILNiLLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQT 1598
Cdd:PHA03095 214 DPAATDMLGNTPLHSMatgSSCKRSLVLP-LLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNT 292
|
90 100
....*....|....*....|...
gi 578838729 1599 AMKLA----SSDTMKRFLSDHLS 1617
Cdd:PHA03095 293 PLSLMvrnnNGRAVRAALAKNPS 315
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
1516-1612 |
4.79e-04 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 45.24 E-value: 4.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1516 LQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGA--DPTLAT 1593
Cdd:PLN03192 544 LLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASisDPHAAG 623
|
90
....*....|....*....
gi 578838729 1594 YSGQTAMKLASSDTMKRFL 1612
Cdd:PLN03192 624 DLLCTAAKRNDLTAMKELL 642
|
|
| PRK05641 |
PRK05641 |
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated |
271-322 |
8.54e-04 |
|
putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated
Pssm-ID: 235540 [Multi-domain] Cd Length: 153 Bit Score: 41.77 E-value: 8.54e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 578838729 271 DSNPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSApplALIQAPVP 322
Cdd:PRK05641 44 DLSAVQEQVPTPAPAPAPAVPSAPTPVAPAAPAPAPASAGE---NVVTAPMP 92
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
197-336 |
1.04e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 43.93 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 197 SPLPAPICPPAPGSASVPHSVPdafqVPLSVPAPVPHsglvPVQVATSVPAPSPPLAPVPALApappsvptlisdSNPLS 276
Cdd:PRK14951 372 AAAPAEKKTPARPEAAAPAAAP----VAQAAAAPAPA----AAPAAAASAPAAPPAAAPPAPV------------AAPAA 431
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578838729 277 VSASVLVPVPASAPPSGPVPLSAPAPAPLSVPV-SAPPLALIQAPVPPSAPTLVLAPVPTP 336
Cdd:PRK14951 432 AAPAAAPAAAPAAVALAPAPPAQAAPETVAIPVrVAPEPAVASAAPAPAAAPAAARLTPTE 492
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
1489-1588 |
1.13e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 43.85 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1489 LIVNKNAGETLLQRAARLGYKDVVLYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHG---ANVNCSAQ--DG 1563
Cdd:cd22192 10 LLQQKRISESPLLLAAKENDVQAIKKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAApelVNEPMTSDlyQG 89
|
90 100
....*....|....*....|....*
gi 578838729 1564 TRPVHDAVVNDNLETIWLLLSYGAD 1588
Cdd:cd22192 90 ETALHIAVVNQNLNLVRELIARGAD 114
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
1497-1603 |
1.22e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 43.41 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1497 ETLLQRAARLGYKDVVlYCLQKDSEDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDGTRPVHDAVVNDNL 1576
Cdd:PHA02874 125 KTFLHYAIKKGDLESI-KMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDY 203
|
90 100
....*....|....*....|....*..
gi 578838729 1577 ETIWLLLSYGADPTLATYSGQTAMKLA 1603
Cdd:PHA02874 204 ACIKLLIDHGNHIMNKCKNGFTPLHNA 230
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
1496-1588 |
1.48e-03 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 43.32 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1496 GETLLQRAARLGYKDVVLYCLqKDSEDVNHRDNAGYTALHEACSRGWTDILNI--------------------------- 1548
Cdd:PLN03192 558 GRTPLHIAASKGYEDCVLVLL-KHACNVHIRDANGNTALWNAISAKHHKIFRIlyhfasisdphaagdllctaakrndlt 636
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 578838729 1549 ----LLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGAD 1588
Cdd:PLN03192 637 amkeLLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD 680
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
274-569 |
1.75e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 43.33 E-value: 1.75e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 274 PLSVSASVLVPVPASAPPSG--PVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPvptpvlapmpastppaapa 351
Cdd:PRK12323 375 ATAAAAPVAQPAPAAAAPAAaaPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAA------------------- 435
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 352 ppsvpmptptpssgppstptlipafaptpvpaPTPAPIFTPAPTPMPAATPAAIPTSAPIPASFSLSRVCFPAAQAPAMQ 431
Cdd:PRK12323 436 --------------------------------ARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARA 483
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 432 KVPLSFQPGTVLTPsqPLVYIPPpscgqplsvatlpttlgvsstlTLPVLPSYLQDRCLPGVLASPELRSYPYAFSVARP 511
Cdd:PRK12323 484 APAAAPAPADDDPP--PWEELPP----------------------EFASPAPAQPDAAPAGWVAESIPDPATADPDDAFE 539
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 578838729 512 ltsdsklvSLEVNRLPCTSPSGSTTTQPAPDGVPGPLADTSLVTASAKVLPTPQPLLP 569
Cdd:PRK12323 540 --------TLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAARLP 589
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1508-1590 |
1.96e-03 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 42.70 E-value: 1.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1508 YKDVVLyCLQKDSEDVNHRDNAGYTALH-EACSRGWTDILNILLEHGANVNCSAQDGTRPVHD--AVVNDNLETIWLLLS 1584
Cdd:PHA03095 62 VKDIVR-LLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLR 140
|
....*.
gi 578838729 1585 YGADPT 1590
Cdd:PHA03095 141 KGADVN 146
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
274-337 |
2.71e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 42.39 E-value: 2.71e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578838729 274 PLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLAlIQAPVPPSAPTLVLAPVPTPV 337
Cdd:PRK14951 391 AAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAA-APAAAPAAAPAAVALAPAPPA 453
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
1549-1603 |
3.10e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 37.33 E-value: 3.10e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 578838729 1549 LLEHG-ANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLA 1603
Cdd:pfam13857 1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
273-471 |
3.24e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 42.39 E-value: 3.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 273 NPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPVPtpvlapmpastppaapap 352
Cdd:PRK14951 372 AAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAA------------------ 433
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 353 psvpmptptpssgppstptlipafaptpvpaptpapiftPAPTPMPAATPAAIPTSAPIPAsfslsrvcfpaaqAPAMQK 432
Cdd:PRK14951 434 ---------------------------------------PAAAPAAAPAAVALAPAPPAQA-------------APETVA 461
|
170 180 190
....*....|....*....|....*....|....*....
gi 578838729 433 VPLSFQPGTVLTPSqplvyiPPPSCGQPLSVATLPTTLG 471
Cdd:PRK14951 462 IPVRVAPEPAVASA------APAPAAAPAAARLTPTEEG 494
|
|
| PHA02795 |
PHA02795 |
ankyrin-like protein; Provisional |
1521-1563 |
3.32e-03 |
|
ankyrin-like protein; Provisional
Pssm-ID: 165157 [Multi-domain] Cd Length: 437 Bit Score: 41.90 E-value: 3.32e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 578838729 1521 EDVNHRDNAGYTALHEACSRGWTDILNILLEHGANVNCSAQDG 1563
Cdd:PHA02795 212 EDINQLDAGGRTLLYRAIYAGYIDLVSWLLENGANVNAVMSNG 254
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
206-335 |
3.38e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 42.14 E-value: 3.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 206 PAPGSASVPHSVPDAfQVPLSVPAPVPHSGLVPvqvATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLSVSASvlVPV 285
Cdd:PRK07003 360 PAVTGGGAPGGGVPA-RVAGAVPAPGARAAAAV---GASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAP--APP 433
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 578838729 286 PASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPVPT 335
Cdd:PRK07003 434 ATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASD 483
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
1544-1605 |
4.17e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 41.57 E-value: 4.17e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578838729 1544 DILNILLEHGANVNCSAQDGTRPVHDAVVN--DNLETIWLLLSYGADPTLATYSGQTAMKLASS 1605
Cdd:PHA03100 87 EIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLYLE 150
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
180-353 |
4.18e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 42.14 E-value: 4.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 180 GTGVPVEGTLPLVTTNFSPLPAPICPPAPGSASVPHSVPdafqVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALA 259
Cdd:PRK07003 363 TGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTA----VTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADR 438
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 260 PAPPSVPTLisdsnPLSVSASVLVPVPASAPPSGPVPLSAPAPAplSVPVSAPPLALIQAPVPPSAPTLVLAPVPTPVLA 339
Cdd:PRK07003 439 GDDAADGDA-----PVPAKANARASADSRCDERDAQPPADSGSA--SAPASDAPPDAAFEPAPRAAAPSAATPAAVPDAR 511
|
170
....*....|....
gi 578838729 340 PMPASTPPAAPAPP 353
Cdd:PRK07003 512 APAAASREDAPAAA 525
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
74-336 |
6.03e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.85 E-value: 6.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 74 ADPDGSATEKLGHKSEDKPDDPQPKMDYAGNVAEAEGLLVPLSSPGDGLKLPASDSAEASNSRADCSwTPLNTQMSKQVD 153
Cdd:PHA03247 2718 ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLT-RPAVASLSESRE 2796
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 154 CSPAGVKALDSRQGVGEKNTFILATLGTGVPVEGTLPLVTTNFSPLPAPICPPAPGSASVPHSVPDAFQVPLSVPAPVPH 233
Cdd:PHA03247 2797 SLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPA 2876
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 234 SGLVPVQVATSVPAPSPPLAPVPALAPAPPSVPTLISDSNPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPP 313
Cdd:PHA03247 2877 APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
|
250 260
....*....|....*....|....*.
gi 578838729 314 LALIQAPVPPSAPTLVLAP---VPTP 336
Cdd:PHA03247 2957 GAVPQPWLGALVPGRVAVPrfrVPQP 2982
|
|
| PRK12727 |
PRK12727 |
flagellar biosynthesis protein FlhF; |
197-338 |
6.04e-03 |
|
flagellar biosynthesis protein FlhF;
Pssm-ID: 237182 [Multi-domain] Cd Length: 559 Bit Score: 41.51 E-value: 6.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 197 SPLPAPICPPAPGSASVPHSVPDAFQ---------VPLSVPAPVPHSGLVPVQV-ATSVPAPSPPLAPVPALAPAPPSVP 266
Cdd:PRK12727 77 TKPAAPVHAPLKLSANANMSQRQRVAsaaedmiaaMALRQPVSVPRQAPAAAPVrAASIPSPAAQALAHAAAVRTAPRQE 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 267 TLISdSNPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLA-------------------LIQAPVPPSAPT 327
Cdd:PRK12727 157 HALS-AVPEQLFADFLTTAPVPRAPVQAPVVAAPAPVPAIAAALAAHAAyaqdddeqldddgfdlddaLPQILPPAALPP 235
|
170
....*....|.
gi 578838729 328 LVLAPVPTPVL 338
Cdd:PRK12727 236 IVVAPAAPAAL 246
|
|
| FAP |
pfam07174 |
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment ... |
284-337 |
7.51e-03 |
|
Fibronectin-attachment protein (FAP); This family contains bacterial fibronectin-attachment proteins (FAP). Family members are rich in alanine and proline, are approximately 300 long, and seem to be restricted to mycobacteria. These proteins contain a fibronectin-binding motif that allows mycobacteria to bind to fibronectin in the extracellular matrix.
Pssm-ID: 429334 Cd Length: 301 Bit Score: 40.29 E-value: 7.51e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 578838729 284 PVPASAPPS--GPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPVPTPV 337
Cdd:pfam07174 41 PEPAPPPPStaTAPPAPPPPPPAPAAPAPPPPPAAPNAPNAPPPPADPNAPPPPPA 96
|
|
| rad23 |
TIGR00601 |
UV excision repair protein Rad23; All proteins in this family for which functions are known ... |
272-337 |
8.12e-03 |
|
UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273167 [Multi-domain] Cd Length: 378 Bit Score: 40.65 E-value: 8.12e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578838729 272 SNPLSVSASVlvPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTlvlAPVPTPV 337
Cdd:TIGR00601 75 SKPKTGTGKV--APPAATPTSAPTPTPSPPASPASGMSAAPASAVEEKSPSEESAT---ATAPESP 135
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
1545-1614 |
8.33e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 40.82 E-value: 8.33e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578838729 1545 ILNILLEHGANVNCSAQDGTRPVHDAVVNDNLETIWLLLSYGADPTLATYSGQTAMKLASS----DTMKRFLSD 1614
Cdd:PHA02876 160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDskniDTIKAIIDN 233
|
|
| PRK07994 |
PRK07994 |
DNA polymerase III subunits gamma and tau; Validated |
197-329 |
8.38e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236138 [Multi-domain] Cd Length: 647 Bit Score: 41.00 E-value: 8.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 197 SPLPAPICPPA---PGSASVPHSVPDAFQVPLSVPAPVPHSGLVPVQVATSVPAPSPPLAPVPALAPAPPSVPTLISDSN 273
Cdd:PRK07994 363 APLPEPEVPPQsaaPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKKSE 442
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578838729 274 PLSVSASV--------LVPVPASAPPSGPVPLSAPA-------PAPLSVPVSAPPLALIQAPVPPSAPTLV 329
Cdd:PRK07994 443 PAAASRARpvnsalerLASVRPAPSALEKAPAKKEAyrwkatnPVEVKKEPVATPKALKKALEHEKTPELA 513
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
206-351 |
9.14e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 40.85 E-value: 9.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 206 PAPGSASVPHSVPDAFQVPlSVPAPVPHSGLVPVQVATSVPAPspplapvpalapappsvptlisdsnPLSVSASVLVPV 285
Cdd:PRK14951 366 PAAAAEAAAPAEKKTPARP-EAAAPAAAPVAQAAAAPAPAAAP-------------------------AAAASAPAAPPA 419
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578838729 286 PASAPPSGPVPLSAPAPAPLSVPVSAPPlalIQAPVPPSAPTLVLAPVPTPVLAPMPASTPPAAPA 351
Cdd:PRK14951 420 AAPPAPVAAPAAAAPAAAPAAAPAAVAL---APAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAA 482
|
|
| PHA02716 |
PHA02716 |
CPXV016; CPX019; EVM010; Provisional |
1512-1600 |
9.15e-03 |
|
CPXV016; CPX019; EVM010; Provisional
Pssm-ID: 165089 [Multi-domain] Cd Length: 764 Bit Score: 41.05 E-value: 9.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 1512 VLYCLQKDSEDVNHRDNAGYTALHEACSRGW--TDILNILLEHGANVNCSAQDGTRPVHD-----AVVND---------N 1575
Cdd:PHA02716 299 VVYSFLQPGVKLHYKDSAGRTCLHQYILRHNisTDIIKLLHEYGNDLNEPDNIGNTVLHTylsmlSVVNIldpetdndiR 378
|
90 100
....*....|....*....|....*
gi 578838729 1576 LETIWLLLSYGADPTLATYSGQTAM 1600
Cdd:PHA02716 379 LDVIQCLISLGADITAVNCLGYTPL 403
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
278-406 |
9.62e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 40.85 E-value: 9.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578838729 278 SASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPLALIQAPVPPSAPTLVLAPVPTPVLAPMPASTPPAAPAPPSVPM 357
Cdd:PRK14951 367 AAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVA 446
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 578838729 358 PTPTPSSGPPSTPTLIPAFAPTPVPaptpapifTPAPTPMPAATPAAIP 406
Cdd:PRK14951 447 LAPAPPAQAAPETVAIPVRVAPEPA--------VASAAPAPAAAPAAAR 487
|
|
| |
