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Conserved domains on  [gi|578837215|ref|XP_006724309|]
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splicing regulator ARVCF isoform X10 [Homo sapiens]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 11997871)

armadillo/beta-catenin-like repeat-containing protein similar to splicing regulator ARVCF, an armadillo repeat protein deleted in velo-cardio-facial syndrome

CATH:  1.25.10.10
Gene Ontology:  GO:0098609|GO:0005515
PubMed:  12946625|9770300|9298899|20688255
SCOP:  3000116

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 350-391 3.99e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 50.12  E-value: 3.99e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 578837215   350 DTDNKAAIRDCGGVPALVRLLRaARDNEVRELVTGTLWNLSS 391
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLK-SEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 307-346 2.09e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.83  E-value: 2.09e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 578837215  307 NEGVKRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLS 346
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 620-655 6.45e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


:

Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.65  E-value: 6.45e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 578837215   620 RATVRKERGLPVLVELLQSETDKVVRAVAIALRNLS 655
Cdd:smart00185   5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 574-610 5.74e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.51  E-value: 5.74e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 578837215  574 ELLYQPEVVRLYLSLLTeSRNFNTLEAAAGALQNLSA 610
Cdd:pfam00514   6 QAVIEAGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
 
Name Accession Description Interval E-value
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 350-391 3.99e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 50.12  E-value: 3.99e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 578837215   350 DTDNKAAIRDCGGVPALVRLLRaARDNEVRELVTGTLWNLSS 391
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLK-SEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 350-391 7.56e-08

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 49.38  E-value: 7.56e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 578837215  350 DTDNKAAIRDCGGVPALVRLLRAArDNEVRELVTGTLWNLSS 391
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSP-DEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 307-346 2.09e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.83  E-value: 2.09e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 578837215  307 NEGVKRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLS 346
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 307-347 2.42e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.81  E-value: 2.42e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 578837215   307 NEGVKRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLSY 347
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 620-655 6.45e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.65  E-value: 6.45e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 578837215   620 RATVRKERGLPVLVELLQSETDKVVRAVAIALRNLS 655
Cdd:smart00185   5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 278-391 1.39e-05

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 49.33  E-value: 1.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837215  278 LPEVLAMLRHPVDPVKANAAAYLQHLCFENEgvkRRVRQLRG--LPLLVALLDHPRAEVRRRACGALRNLSYGRDTDN-- 353
Cdd:PLN03200   60 MPLLVSLLRSGTLGAKVNAAAVLGVLCKEED---LRVKVLLGgcIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSDHvg 136

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 578837215  354 -KAAIRDcGGVPALVRLLRA--ARDNEVRELVTGTLWNLSS 391
Cdd:PLN03200  137 sKIFSTE-GVVPSLWDQLQPgnKQDKVVEGLLTGALRNLCG 176
HEAT COG1413
HEAT repeat [General function prediction only];
272-389 9.42e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.08  E-value: 9.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837215 272 RWRDPE-LPEVLAMLRHPVDPVKANAAAYLqhlcfenegvkRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLsygrd 350
Cdd:COG1413   42 RLGDPRaVPALLEALKDPDPEVRAAAAEAL-----------GRIGDPEAVPALIAALKDEDPEVRRAAAEALGRL----- 105

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 578837215 351 tDNKAAirdcggVPALVRLLRAArDNEVRELVTGTLWNL 389
Cdd:COG1413  106 -GDPAA------VPALLEALKDP-DWEVRRAAARALGRL 136
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 620-655 1.56e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.75  E-value: 1.56e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578837215  620 RATVRKERGLPVLVELLQSETDKVVRAVAIALRNLS 655
Cdd:pfam00514   5 KQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 574-610 5.74e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.51  E-value: 5.74e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 578837215  574 ELLYQPEVVRLYLSLLTeSRNFNTLEAAAGALQNLSA 610
Cdd:pfam00514   6 QAVIEAGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
 
Name Accession Description Interval E-value
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 350-391 3.99e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 50.12  E-value: 3.99e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 578837215   350 DTDNKAAIRDCGGVPALVRLLRaARDNEVRELVTGTLWNLSS 391
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLK-SEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 350-391 7.56e-08

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 49.38  E-value: 7.56e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 578837215  350 DTDNKAAIRDCGGVPALVRLLRAArDNEVRELVTGTLWNLSS 391
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSP-DEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 307-346 2.09e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.83  E-value: 2.09e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 578837215  307 NEGVKRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLS 346
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 307-347 2.42e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.81  E-value: 2.42e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 578837215   307 NEGVKRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLSY 347
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 620-655 6.45e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 46.65  E-value: 6.45e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 578837215   620 RATVRKERGLPVLVELLQSETDKVVRAVAIALRNLS 655
Cdd:smart00185   5 KQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 278-391 1.39e-05

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 49.33  E-value: 1.39e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837215  278 LPEVLAMLRHPVDPVKANAAAYLQHLCFENEgvkRRVRQLRG--LPLLVALLDHPRAEVRRRACGALRNLSYGRDTDN-- 353
Cdd:PLN03200   60 MPLLVSLLRSGTLGAKVNAAAVLGVLCKEED---LRVKVLLGgcIPPLLSLLKSGSAEAQKAAAEAIYAVSSGGLSDHvg 136

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 578837215  354 -KAAIRDcGGVPALVRLLRA--ARDNEVRELVTGTLWNLSS 391
Cdd:PLN03200  137 sKIFSTE-GVVPSLWDQLQPgnKQDKVVEGLLTGALRNLCG 176
HEAT COG1413
HEAT repeat [General function prediction only];
272-389 9.42e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.08  E-value: 9.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837215 272 RWRDPE-LPEVLAMLRHPVDPVKANAAAYLqhlcfenegvkRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLsygrd 350
Cdd:COG1413   42 RLGDPRaVPALLEALKDPDPEVRAAAAEAL-----------GRIGDPEAVPALIAALKDEDPEVRRAAAEALGRL----- 105

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 578837215 351 tDNKAAirdcggVPALVRLLRAArDNEVRELVTGTLWNL 389
Cdd:COG1413  106 -GDPAA------VPALLEALKDP-DWEVRRAAARALGRL 136
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 620-655 1.56e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.75  E-value: 1.56e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 578837215  620 RATVRKERGLPVLVELLQSETDKVVRAVAIALRNLS 655
Cdd:pfam00514   5 KQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 278-380 3.70e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 37.32  E-value: 3.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837215  278 LPEVLAMLRHPVDP-VKANAAAYLQHLCFEnegvkrrvrqlRGLPLLVALLDHPRAEVRRRACGALrnlsygrdtdnkAA 356
Cdd:pfam13646   1 LPALLQALLRDPDPeVRAAAIRALGRIGDP-----------EAVPALLELLKDEDPAVRRAAAEAL------------GK 57

                          90       100
                  ....*....|....*....|....
gi 578837215  357 IRDCGGVPALVRLLRAARDNEVRE 380
Cdd:pfam13646  58 IGDPEALPALLELLRDDDDDVVRA 81
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 574-610 5.74e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 35.51  E-value: 5.74e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 578837215  574 ELLYQPEVVRLYLSLLTeSRNFNTLEAAAGALQNLSA 610
Cdd:pfam00514   6 QAVIEAGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 300-414 8.80e-03

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 40.09  E-value: 8.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578837215  300 LQHLCFENEGVKRRVRQLRGLPLLVALLDHPRAEVRRRACGALRNLSYGrDTDNKAAIRDCGGVPALVRLLRAARDNEVR 379
Cdd:PLN03200  171 LRNLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQANAASLLARLMMA-FESSISKVLDAGAVKQLLKLLGQGNEVSVR 249

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 578837215  380 ELVTGTLWNLSSYEP-LKMVIIDH-GLQTLTHEVIVP 414
Cdd:PLN03200  250 AEAAGALEALSSQSKeAKQAIADAgGIPALINATVAP 286
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 320-345 9.55e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.42  E-value: 9.55e-03
                          10        20
                  ....*....|....*....|....*.
gi 578837215  320 LPLLVALLDHPRAEVRRRACGALRNL 345
Cdd:pfam13513  30 LPALLPLLNDDSDLVREAAAWALGRL 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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