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Conserved domains on  [gi|578836003|ref|XP_006723861|]
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laminin subunit alpha-5 isoform X7 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
45-298 2.44e-95

Laminin N-terminal (Domain VI);


:

Pssm-ID: 459653  Cd Length: 230  Bit Score: 307.59  E-value: 2.44e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003    45 LHPPYFNLAEGARIAASATCGEEAPargsprpteDLYCKLVGGPvaggdpnqtiRGQYCDICTAANSNKAHPASNAIDGT 124
Cdd:pfam00055    1 CYPAFGNLAFGREVSATSTCGLNGP---------ERYCILSGLE----------GGKKCFICDSRDPHNSHPPSNLTDSN 61

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003   125 ER----WWQSPPLSrgLEYNEVNVTLDLGQVFHVAYVLIKFAnSPRPDLWVLERSMDFGRTYQPWQFFASskrDCLERFG 200
Cdd:pfam00055   62 NGtnetWWQSETGV--IQYENVNLTLDLGKEFHFTYLILKFK-SPRPAAMVLERSTDFGKTWQPYQYFAS---DCRRTFG 135

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003   201 -PQTLERITRDDAAICTTEYSRIVPLENGEIVVSLVNGRPGAMNFSYSPLLREFTKATNVRLRFLRTNTLLGHLmgkaLR 279
Cdd:pfam00055  136 rPSGPSRGIKDDEVICTSEYSDISPLTGGEVIFSTLEGRPSANIFDYSPELQDWLTATNIRIRLLRLHTLGDEL----LD 211

                          250
                   ....*....|....*....
gi 578836003   280 DPTVTRRYYYSIKDISIGG 298
Cdd:pfam00055  212 DPSVLRKYYYAISDISVGG 230
Laminin_B pfam00052
Laminin B (Domain IV);
1693-1829 3.15e-48

Laminin B (Domain IV);


:

Pssm-ID: 459652  Cd Length: 136  Bit Score: 168.99  E-value: 3.15e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003  1693 YWQAPPSYLGDRVSSYGGTLRYELHSETQRGDVfvPMESRPDVVLQGNQMSITFLEPA--YPTPGHVHRGQLQLVEGNFR 1770
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGG--SLNSEPDVILEGNGLRLSYSSPDqpPPDPGQEQTYSVRLHEENWR 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 578836003  1771 HTeTRNTVSREELMMVLASLEQLQIRALFSQISSAVFLRRVALEVASPAGQGALASNVE 1829
Cdd:pfam00052   79 DS-DGAPVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAVPGGSGPPASWVE 136
Laminin_I super family cl26988
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ...
 2192-2290 6.92e-30

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


The actual alignment was detected with superfamily member pfam06008:

Pssm-ID: 310534 [Multi-domain]  Cd Length: 258  Bit Score: 120.60  E-value: 6.92e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003  2192 LRGINASSMAWARLHRLNASIADLQSQLRSPLGPRHETAQQLEVLEQQSTSLGQDARRLGGQAVGTRDQASQLLAGTEAT 2271
Cdd:pfam06008    1 LLSLNSLTGALPAPYKINYNLENLTKQLQEYLSPENAHKIQIEILEKELSSLAQETEELQKKATQTLAKAQQVNAESERT 80

                           90
                   ....*....|....*....
gi 578836003  2272 LGHAKTLLAAIRAVDRTLS 2290
Cdd:pfam06008   81 LGHAKELAEAIKNLIDNIK 99
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1438-1486 3.21e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 60.06  E-value: 3.21e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578836003  1438 CGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFPNCRPCDC 1486
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1577-1625 4.84e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 59.67  E-value: 4.84e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578836003  1577 CDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTFSLDAANPKGC 1625
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 540-583 3.15e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 57.36  E-value: 3.15e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 578836003  540 PCQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPL 583
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 676-718 8.21e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 56.21  E-value: 8.21e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 578836003  676 PCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCVPGAYNFP 718
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 2069-2113 1.24e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.82  E-value: 1.24e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 578836003 2069 PCAC-GPAAEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQG 2113
Cdd:cd00055     1 PCDCnGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 587-634 1.29e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 55.44  E-value: 1.29e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578836003   587 CGCSPAGTLPEGCD-EAGRCLCQPEFAGPHCDRCRPGYHGFPNCQACTC 634
Cdd:pfam00053    1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1528-1579 4.66e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.90  E-value: 4.66e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 578836003  1528 CNCSGPGIqelTDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYPRCRPCDC 1579
Cdd:pfam00053    1 CDCNPHGS---LSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
2023-2065 7.14e-09

Laminin-type epidermal growth factor-like domai;


:

Pssm-ID: 214543  Cd Length: 46  Bit Score: 53.47  E-value: 7.14e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 578836003   2023 CDCTPCGT--EACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGCG 2065
Cdd:smart00180    1 CDCDPGGSasGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPG 45
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1968-2021 7.72e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.51  E-value: 7.72e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 578836003 1968 PCDCSGNGDPNllfSDCDPLTGACRgCLRHTTGPRCEICAPGFYGNALLPGNCT 2021
Cdd:cd00055     1 PCDCNGHGSLS---GQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
494-541 1.05e-08

Laminin-type epidermal growth factor-like domai;


:

Pssm-ID: 214543  Cd Length: 46  Bit Score: 53.08  E-value: 1.05e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 578836003    494 CDCSAAGTQGNACrkDPRVGRCLCKPNFQGTHCELCAPGFYGPGCQPC 541
Cdd:smart00180    1 CDCDPGGSASGTC--DPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 632-679 1.00e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.43  E-value: 1.00e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578836003   632 CTCDPRGALDQLC-GAGGLCRCRPGYTGTACQECSPGFHGFPSCVPCHC 679
Cdd:pfam00053    1 CDCNPHGSLSDTCdPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 775-827 3.07e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 48.89  E-value: 3.07e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 578836003  775 RCSCDLRGTLGGvaECQPGTGQCFCKPHVCGQACASCKDGFFGlDQADYFGCR 827
Cdd:cd00055     1 PCDCNGHGSLSG--QCDPGTGQCECKPNTTGRRCDRCAPGYYG-LPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1913-1966 2.92e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 46.19  E-value: 2.92e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 578836003  1913 CPCPLSVPSNnfaEGCVLRGGrtQCLCKPGYAGASCERCAPGFFGNPLVLGSSC 1966
Cdd:pfam00053    1 CDCNPHGSLS---DTCDPETG--QCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 828-867 4.93e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.42  E-value: 4.93e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 578836003  828 SCRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHY 867
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYY 40
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1863-1899 5.13e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.42  E-value: 5.13e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 578836003 1863 PCQCHGH---SDRCLPGSGVCVdCQHNTEGAHCERCQAGF 1899
Cdd:cd00055     1 PCDCNGHgslSGQCDPGTGQCE-CKPNTTGRRCDRCAPGY 39
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 429-473 1.12e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 44.27  E-value: 1.12e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 578836003   429 CNC-ESDFTDGTCEDLTGRCYCRPNFSGERCDVCAEGFTGFPSCYP 473
Cdd:pfam00053    1 CDCnPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPP 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 299-347 1.27e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 44.27  E-value: 1.27e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 578836003  299 RCVCHGHADACDAKDPTDpfrLQCTCQHNTCGGTCDRCCPGFNQQPWKP 347
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGT---GQCECKPNTTGRRCDRCAPGYYGLPSQG 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 744-773 2.79e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


:

Pssm-ID: 395007  Cd Length: 49  Bit Score: 43.50  E-value: 2.79e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 578836003   744 CMCRAHVEGPSCDRCKPGFWGLSPSNPEGC 773
Cdd:pfam00053   20 CLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 387-421 2.64e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


:

Pssm-ID: 238012  Cd Length: 50  Bit Score: 37.72  E-value: 2.64e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 578836003  387 YQGGGVCIdCQHHTTGVNCERCLPGFYRSPNHPLD 421
Cdd:cd00055    15 DPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_CA super family cl21504
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2117-2145 6.07e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


The actual alignment was detected with superfamily member pfam00053:

Pssm-ID: 473889  Cd Length: 49  Bit Score: 36.56  E-value: 6.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 578836003  2117 CQCPG-----GRCDPHTGRCNCPPGLSGERCDTC 2145
Cdd:pfam00053    1 CDCNPhgslsDTCDPETGQCLCKPGVTGRHCDRC 34
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
45-298 2.44e-95

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 307.59  E-value: 2.44e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003    45 LHPPYFNLAEGARIAASATCGEEAPargsprpteDLYCKLVGGPvaggdpnqtiRGQYCDICTAANSNKAHPASNAIDGT 124
Cdd:pfam00055    1 CYPAFGNLAFGREVSATSTCGLNGP---------ERYCILSGLE----------GGKKCFICDSRDPHNSHPPSNLTDSN 61

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003   125 ER----WWQSPPLSrgLEYNEVNVTLDLGQVFHVAYVLIKFAnSPRPDLWVLERSMDFGRTYQPWQFFASskrDCLERFG 200
Cdd:pfam00055   62 NGtnetWWQSETGV--IQYENVNLTLDLGKEFHFTYLILKFK-SPRPAAMVLERSTDFGKTWQPYQYFAS---DCRRTFG 135

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003   201 -PQTLERITRDDAAICTTEYSRIVPLENGEIVVSLVNGRPGAMNFSYSPLLREFTKATNVRLRFLRTNTLLGHLmgkaLR 279
Cdd:pfam00055  136 rPSGPSRGIKDDEVICTSEYSDISPLTGGEVIFSTLEGRPSANIFDYSPELQDWLTATNIRIRLLRLHTLGDEL----LD 211

                          250
                   ....*....|....*....
gi 578836003   280 DPTVTRRYYYSIKDISIGG 298
Cdd:pfam00055  212 DPSVLRKYYYAISDISVGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 44-298 1.37e-91

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 297.35  E-value: 1.37e-91
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003     44 SLHPPYFNLAEGARIAASATCGEEAPARgsprptedlYCKLVGGpvaggdpnqTIRGQYCDICTAANSNKAHPASNAIDG 123
Cdd:smart00136    6 SCYPPFVNLAFGREVTATSTCGEPGPER---------YCKLVGH---------TEQGKKCDYCDARNPRRSHPAENLTDG 67

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003    124 TE----RWWQSPPLSRGLEYneVNVTLDLGQVFHVAYVLIKFAnSPRPDLWVLERSmDFGRTYQPWQFFASskrDCLERF 199
Cdd:smart00136   68 NNpnnpTWWQSEPLSNGPQN--VNLTLDLGKEFHVTYVILKFC-SPRPSLWILERS-DFGKTWQPWQYFSS---DCRRTF 140

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003    200 GPQTLERITR--DDAAICTTEYSRIVPLENGEIVVSLVNGRPGAMNFSYSPLLREFTKATNVRLRFLRTNTLLGHLMGKA 277
Cdd:smart00136  141 GRPPRGPITKgnEDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDFDNSPVLQEWVTATNIRVRLTRLRTLGDELMDDR 220

                           250       260
                    ....*....|....*....|.
gi 578836003    278 lrdPTVTRRYYYSIKDISIGG 298
Cdd:smart00136  221 ---PEVTRRYYYAISDIAVGG 238
Laminin_B pfam00052
Laminin B (Domain IV);
1693-1829 3.15e-48

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 168.99  E-value: 3.15e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003  1693 YWQAPPSYLGDRVSSYGGTLRYELHSETQRGDVfvPMESRPDVVLQGNQMSITFLEPA--YPTPGHVHRGQLQLVEGNFR 1770
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGG--SLNSEPDVILEGNGLRLSYSSPDqpPPDPGQEQTYSVRLHEENWR 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 578836003  1771 HTeTRNTVSREELMMVLASLEQLQIRALFSQISSAVFLRRVALEVASPAGQGALASNVE 1829
Cdd:pfam00052   79 DS-DGAPVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAVPGGSGPPASWVE 136
LamB smart00281
Laminin B domain;
1689-1818 1.28e-44

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 158.19  E-value: 1.28e-44
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003   1689 FPELYWQAPPSYLGDRVSSYGGTLRYELHSETQRGDVFVpmeSRPDVVLQGNQMSITFLEPAYPTPGHVHRGQLQLVEGN 1768
Cdd:smart00281    2 NEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDGRRGGTHV---SAPDVILEGNGLRISHPAEGPPLPDELTTVEVRFREEN 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|
gi 578836003   1769 FRHTETRnTVSREELMMVLASLEQLQIRALFSQISSAVFLRRVALEVASP 1818
Cdd:smart00281   79 WQYYGGR-PVTREDLMMVLANLTAILIRATYSQQMAGSRLSDVSLEVAVP 127
Laminin_I pfam06008
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ...
 2192-2290 6.92e-30

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 310534 [Multi-domain]  Cd Length: 258  Bit Score: 120.60  E-value: 6.92e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003  2192 LRGINASSMAWARLHRLNASIADLQSQLRSPLGPRHETAQQLEVLEQQSTSLGQDARRLGGQAVGTRDQASQLLAGTEAT 2271
Cdd:pfam06008    1 LLSLNSLTGALPAPYKINYNLENLTKQLQEYLSPENAHKIQIEILEKELSSLAQETEELQKKATQTLAKAQQVNAESERT 80

                           90
                   ....*....|....*....
gi 578836003  2272 LGHAKTLLAAIRAVDRTLS 2290
Cdd:pfam06008   81 LGHAKELAEAIKNLIDNIK 99
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1438-1486 3.21e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 60.06  E-value: 3.21e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578836003  1438 CGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFPNCRPCDC 1486
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1577-1625 4.84e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 59.67  E-value: 4.84e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578836003  1577 CDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTFSLDAANPKGC 1625
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 540-583 3.15e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 57.36  E-value: 3.15e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 578836003  540 PCQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPL 583
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 676-718 8.21e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 56.21  E-value: 8.21e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 578836003  676 PCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCVPGAYNFP 718
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1576-1626 1.17e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.82  E-value: 1.17e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 578836003 1576 PCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTFSlDAANPKGCT 1626
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYG-LPSQGGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 2069-2113 1.24e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.82  E-value: 1.24e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 578836003 2069 PCAC-GPAAEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQG 2113
Cdd:cd00055     1 PCDCnGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 587-634 1.29e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 55.44  E-value: 1.29e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578836003   587 CGCSPAGTLPEGCD-EAGRCLCQPEFAGPHCDRCRPGYHGFPNCQACTC 634
Cdd:pfam00053    1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1437-1479 1.48e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.44  E-value: 1.48e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 578836003 1437 PCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFP 1479
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
541-582 2.48e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 54.62  E-value: 2.48e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 578836003    541 CQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFP 582
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 541-589 2.72e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 54.67  E-value: 2.72e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578836003   541 CQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPLCQLCGC 589
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
2070-2114 2.93e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 54.62  E-value: 2.93e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 578836003   2070 CACGPA-AEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQGC 2114
Cdd:smart00180    1 CDCDPGgSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1528-1579 4.66e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.90  E-value: 4.66e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 578836003  1528 CNCSGPGIqelTDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYPRCRPCDC 1579
Cdd:pfam00053    1 CDCNPHGS---LSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1577-1615 5.59e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 53.85  E-value: 5.59e-09
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 578836003   1577 CDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTF 1615
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYY 39
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
2023-2065 7.14e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 53.47  E-value: 7.14e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 578836003   2023 CDCTPCGT--EACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGCG 2065
Cdd:smart00180    1 CDCDPGGSasGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPG 45
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1968-2021 7.72e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.51  E-value: 7.72e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 578836003 1968 PCDCSGNGDPNllfSDCDPLTGACRgCLRHTTGPRCEICAPGFYGNALLPGNCT 2021
Cdd:cd00055     1 PCDCNGHGSLS---GQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 2023-2067 7.83e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.51  E-value: 7.83e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 578836003  2023 CDCTPCGT--EACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGCGGC 2067
Cdd:pfam00053    1 CDCNPHGSlsDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQ 47
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 2022-2068 8.68e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.13  E-value: 8.68e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 578836003 2022 RCDCTPCGT--EACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGCG-GCR 2068
Cdd:cd00055     1 PCDCNGHGSlsGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGgGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1528-1572 9.48e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.13  E-value: 9.48e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 578836003 1528 CNCSGPGIQeltDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYP 1572
Cdd:cd00055     2 CDCNGHGSL---SGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 2070-2117 1.04e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.13  E-value: 1.04e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578836003  2070 CACGP-AAEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQGCRRC 2117
Cdd:pfam00053    1 CDCNPhGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
494-541 1.05e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 53.08  E-value: 1.05e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 578836003    494 CDCSAAGTQGNACrkDPRVGRCLCKPNFQGTHCELCAPGFYGPGCQPC 541
Cdd:smart00180    1 CDCDPGGSASGTC--DPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1438-1479 1.84e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 52.31  E-value: 1.84e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 578836003   1438 CGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFP 1479
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 677-725 1.87e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 52.36  E-value: 1.87e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578836003   677 CHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCVPGAYNFPYCEAGSC 725
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1528-1572 1.99e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 52.31  E-value: 1.99e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 578836003   1528 CNCSGPGIQeltDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYP 1572
Cdd:smart00180    1 CDCDPGGSA---SGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
677-719 2.50e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 51.93  E-value: 2.50e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 578836003    677 CHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCVPGAYNFPY 719
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGP 43
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 494-543 5.47e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 51.20  E-value: 5.47e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 578836003  494 CDCSAAGTQGNACrkDPRVGRCLCKPNFQGTHCELCAPGFYGPGCQPCQC 543
Cdd:cd00055     2 CDCNGHGSLSGQC--DPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 587-627 6.40e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 50.82  E-value: 6.40e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 578836003  587 CGCSPAGTLPEGCD-EAGRCLCQPEFAGPHCDRCRPGYHGFP 627
Cdd:cd00055     2 CDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYYGLP 43
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 494-543 6.43e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.81  E-value: 6.43e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 578836003   494 CDCSAAGTQGNACrkDPRVGRCLCKPNFQGTHCELCAPGFYG-PGCQPCQC 543
Cdd:pfam00053    1 CDCNPHGSLSDTC--DPETGQCLCKPGVTGRHCDRCKPGYYGlPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 632-679 1.00e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.43  E-value: 1.00e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578836003   632 CTCDPRGALDQLC-GAGGLCRCRPGYTGTACQECSPGFHGFPSCVPCHC 679
Cdd:pfam00053    1 CDCNPHGSLSDTCdPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 775-827 3.07e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 48.89  E-value: 3.07e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 578836003  775 RCSCDLRGTLGGvaECQPGTGQCFCKPHVCGQACASCKDGFFGlDQADYFGCR 827
Cdd:cd00055     1 PCDCNGHGSLSG--QCDPGTGQCECKPNTTGRRCDRCAPGYYG-LPSQGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
587-627 3.88e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 48.46  E-value: 3.88e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 578836003    587 CGCSPAGTLPEGCD-EAGRCLCQPEFAGPHCDRCRPGYHGFP 627
Cdd:smart00180    1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYYGDG 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1969-2019 5.56e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 48.12  E-value: 5.56e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 578836003  1969 CDCSGNGDPNllfSDCDPLTGACRgCLRHTTGPRCEICAPGFYGNALLPGN 2019
Cdd:pfam00053    1 CDCNPHGSLS---DTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQ 47
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 776-826 1.15e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 47.35  E-value: 1.15e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 578836003   776 CSCDLRGTLGGvaECQPGTGQCFCKPHVCGQACASCKDGFFGLDQADYFGC 826
Cdd:pfam00053    1 CDCNPHGSLSD--TCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
776-817 1.98e-06

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 46.54  E-value: 1.98e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 578836003    776 CSCDLRGTLGGvaECQPGTGQCFCKPHVCGQACASCKDGFFG 817
Cdd:smart00180    1 CDCDPGGSASG--TCDPDTGQCECKPNVTGRRCDRCAPGYYG 40
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1913-1966 2.92e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 46.19  E-value: 2.92e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 578836003  1913 CPCPLSVPSNnfaEGCVLRGGrtQCLCKPGYAGASCERCAPGFFGNPLVLGSSC 1966
Cdd:pfam00053    1 CDCNPHGSLS---DTCDPETG--QCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 828-867 4.93e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.42  E-value: 4.93e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 578836003  828 SCRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHY 867
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYY 40
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1863-1899 5.13e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.42  E-value: 5.13e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 578836003 1863 PCQCHGH---SDRCLPGSGVCVdCQHNTEGAHCERCQAGF 1899
Cdd:cd00055     1 PCDCNGHgslSGQCDPGTGQCE-CKPNTTGRRCDRCAPGY 39
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1864-1910 8.25e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 44.65  E-value: 8.25e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 578836003  1864 CQCHGH---SDRCLPGSGVCvDCQHNTEGAHCERCQAGFVSSRDDPSAPC 1910
Cdd:pfam00053    1 CDCNPHgslSDTCDPETGQC-LCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1913-1959 1.02e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 44.61  E-value: 1.02e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 578836003   1913 CPCPlsvPSNNFAEGCVLRGGrtQCLCKPGYAGASCERCAPGFFGNP 1959
Cdd:smart00180    1 CDCD---PGGSASGTCDPDTG--QCECKPNVTGRRCDRCAPGYYGDG 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 429-473 1.12e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 44.27  E-value: 1.12e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 578836003   429 CNC-ESDFTDGTCEDLTGRCYCRPNFSGERCDVCAEGFTGFPSCYP 473
Cdd:pfam00053    1 CDCnPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPP 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 428-470 1.20e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 44.27  E-value: 1.20e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 578836003  428 RCNCESDFT-DGTCEDLTGRCYCRPNFSGERCDVCAEGFTGFPS 470
Cdd:cd00055     1 PCDCNGHGSlSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 299-347 1.27e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 44.27  E-value: 1.27e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 578836003  299 RCVCHGHADACDAKDPTDpfrLQCTCQHNTCGGTCDRCCPGFNQQPWKP 347
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGT---GQCECKPNTTGRRCDRCAPGYYGLPSQG 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 631-673 1.82e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 43.88  E-value: 1.82e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 578836003  631 ACTCDPRGALDQLCGAG-GLCRCRPGYTGTACQECSPGFHGFPS 673
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGtGQCECKPNTTGRRCDRCAPGYYGLPS 44
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
829-867 2.37e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 43.45  E-value: 2.37e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 578836003    829 CRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHY 867
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYY 39
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 744-773 2.79e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 43.50  E-value: 2.79e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 578836003   744 CMCRAHVEGPSCDRCKPGFWGLSPSNPEGC 773
Cdd:pfam00053   20 CLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
429-469 4.32e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 42.68  E-value: 4.32e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 578836003    429 CNCESDFT-DGTCEDLTGRCYCRPNFSGERCDVCAEGFTGFP 469
Cdd:smart00180    1 CDCDPGGSaSGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1912-1967 9.21e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 41.96  E-value: 9.21e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 578836003 1912 SCPCPlsvPSNNFAEGCVLRGGrtQCLCKPGYAGASCERCAPGFFGNPLVlGSSCQ 1967
Cdd:cd00055     1 PCDCN---GHGSLSGQCDPGTG--QCECKPNTTGRRCDRCAPGYYGLPSQ-GGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1969-2013 1.46e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 41.14  E-value: 1.46e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 578836003   1969 CDCSGNGDpnlLFSDCDPLTGACRgCLRHTTGPRCEICAPGFYGN 2013
Cdd:smart00180    1 CDCDPGGS---ASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD 41
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
632-672 1.96e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 40.76  E-value: 1.96e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 578836003    632 CTCDPRGALDQLC-GAGGLCRCRPGYTGTACQECSPGFHGFP 672
Cdd:smart00180    1 CDCDPGGSASGTCdPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 829-867 5.54e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 39.64  E-value: 5.54e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 578836003   829 CRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHY 867
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYY 39
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1864-1899 1.25e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 38.45  E-value: 1.25e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 578836003   1864 CQCHG---HSDRCLPGSGVCvDCQHNTEGAHCERCQAGF 1899
Cdd:smart00180    1 CDCDPggsASGTCDPDTGQC-ECKPNVTGRRCDRCAPGY 38
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 387-421 2.64e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 37.72  E-value: 2.64e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 578836003  387 YQGGGVCIdCQHHTTGVNCERCLPGFYRSPNHPLD 421
Cdd:cd00055    15 DPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
744-773 3.09e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 37.29  E-value: 3.09e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 578836003    744 CMCRAHVEGPSCDRCKPGFWGlspSNPEGC 773
Cdd:smart00180   20 CECKPNVTGRRCDRCAPGYYG---DGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 387-426 5.39e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.95  E-value: 5.39e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 578836003   387 YQGGGVCiDCQHHTTGVNCERCLPGFYRSPNhplDSPHVC 426
Cdd:pfam00053   14 DPETGQC-LCKPGVTGRHCDRCKPGYYGLPS---DPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 2117-2145 6.07e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.56  E-value: 6.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 578836003  2117 CQCPG-----GRCDPHTGRCNCPPGLSGERCDTC 2145
Cdd:pfam00053    1 CDCNPhgslsDTCDPETGQCLCKPGVTGRHCDRC 34
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 2116-2145 8.04e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 36.56  E-value: 8.04e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 578836003 2116 RCQCPG-----GRCDPHTGRCNCPPGLSGERCDTC 2145
Cdd:cd00055     1 PCDCNGhgslsGQCDPGTGQCECKPNTTGRRCDRC 35
 
Name Accession Description Interval E-value
Laminin_N pfam00055
Laminin N-terminal (Domain VI);
45-298 2.44e-95

Laminin N-terminal (Domain VI);


Pssm-ID: 459653  Cd Length: 230  Bit Score: 307.59  E-value: 2.44e-95
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003    45 LHPPYFNLAEGARIAASATCGEEAPargsprpteDLYCKLVGGPvaggdpnqtiRGQYCDICTAANSNKAHPASNAIDGT 124
Cdd:pfam00055    1 CYPAFGNLAFGREVSATSTCGLNGP---------ERYCILSGLE----------GGKKCFICDSRDPHNSHPPSNLTDSN 61

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003   125 ER----WWQSPPLSrgLEYNEVNVTLDLGQVFHVAYVLIKFAnSPRPDLWVLERSMDFGRTYQPWQFFASskrDCLERFG 200
Cdd:pfam00055   62 NGtnetWWQSETGV--IQYENVNLTLDLGKEFHFTYLILKFK-SPRPAAMVLERSTDFGKTWQPYQYFAS---DCRRTFG 135

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003   201 -PQTLERITRDDAAICTTEYSRIVPLENGEIVVSLVNGRPGAMNFSYSPLLREFTKATNVRLRFLRTNTLLGHLmgkaLR 279
Cdd:pfam00055  136 rPSGPSRGIKDDEVICTSEYSDISPLTGGEVIFSTLEGRPSANIFDYSPELQDWLTATNIRIRLLRLHTLGDEL----LD 211

                          250
                   ....*....|....*....
gi 578836003   280 DPTVTRRYYYSIKDISIGG 298
Cdd:pfam00055  212 DPSVLRKYYYAISDISVGG 230
LamNT smart00136
Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related ...
 44-298 1.37e-91

Laminin N-terminal domain (domain VI); N-terminal domain of laminins and laminin-related protein such as Unc-6/ netrins.


Pssm-ID: 214532  Cd Length: 238  Bit Score: 297.35  E-value: 1.37e-91
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003     44 SLHPPYFNLAEGARIAASATCGEEAPARgsprptedlYCKLVGGpvaggdpnqTIRGQYCDICTAANSNKAHPASNAIDG 123
Cdd:smart00136    6 SCYPPFVNLAFGREVTATSTCGEPGPER---------YCKLVGH---------TEQGKKCDYCDARNPRRSHPAENLTDG 67

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003    124 TE----RWWQSPPLSRGLEYneVNVTLDLGQVFHVAYVLIKFAnSPRPDLWVLERSmDFGRTYQPWQFFASskrDCLERF 199
Cdd:smart00136   68 NNpnnpTWWQSEPLSNGPQN--VNLTLDLGKEFHVTYVILKFC-SPRPSLWILERS-DFGKTWQPWQYFSS---DCRRTF 140

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003    200 GPQTLERITR--DDAAICTTEYSRIVPLENGEIVVSLVNGRPGAMNFSYSPLLREFTKATNVRLRFLRTNTLLGHLMGKA 277
Cdd:smart00136  141 GRPPRGPITKgnEDEVICTSEYSDIVPLEGGEIAFSLLEGRPSATDFDNSPVLQEWVTATNIRVRLTRLRTLGDELMDDR 220

                           250       260
                    ....*....|....*....|.
gi 578836003    278 lrdPTVTRRYYYSIKDISIGG 298
Cdd:smart00136  221 ---PEVTRRYYYAISDIAVGG 238
Laminin_B pfam00052
Laminin B (Domain IV);
1693-1829 3.15e-48

Laminin B (Domain IV);


Pssm-ID: 459652  Cd Length: 136  Bit Score: 168.99  E-value: 3.15e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003  1693 YWQAPPSYLGDRVSSYGGTLRYELHSETQRGDVfvPMESRPDVVLQGNQMSITFLEPA--YPTPGHVHRGQLQLVEGNFR 1770
Cdd:pfam00052    1 YWSAPEQFLGNKLTSYGGYLTYTVRYEPLPGGG--SLNSEPDVILEGNGLRLSYSSPDqpPPDPGQEQTYSVRLHEENWR 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 578836003  1771 HTeTRNTVSREELMMVLASLEQLQIRALFSQISSAVFLRRVALEVASPAGQGALASNVE 1829
Cdd:pfam00052   79 DS-DGAPVSREDFMMVLANLTAILIRATYSTGSGQVSLSNVSLDSAVPGGSGPPASWVE 136
LamB smart00281
Laminin B domain;
1689-1818 1.28e-44

Laminin B domain;


Pssm-ID: 214597  Cd Length: 127  Bit Score: 158.19  E-value: 1.28e-44
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003   1689 FPELYWQAPPSYLGDRVSSYGGTLRYELHSETQRGDVFVpmeSRPDVVLQGNQMSITFLEPAYPTPGHVHRGQLQLVEGN 1768
Cdd:smart00281    2 NEPVYWVAPEQFLGDKVTSYGGKLRYTLSFDGRRGGTHV---SAPDVILEGNGLRISHPAEGPPLPDELTTVEVRFREEN 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|
gi 578836003   1769 FRHTETRnTVSREELMMVLASLEQLQIRALFSQISSAVFLRRVALEVASP 1818
Cdd:smart00281   79 WQYYGGR-PVTREDLMMVLANLTAILIRATYSQQMAGSRLSDVSLEVAVP 127
Laminin_I pfam06008
Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from ...
 2192-2290 6.92e-30

Laminin Domain I; coiled-coil structure. It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.


Pssm-ID: 310534 [Multi-domain]  Cd Length: 258  Bit Score: 120.60  E-value: 6.92e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003  2192 LRGINASSMAWARLHRLNASIADLQSQLRSPLGPRHETAQQLEVLEQQSTSLGQDARRLGGQAVGTRDQASQLLAGTEAT 2271
Cdd:pfam06008    1 LLSLNSLTGALPAPYKINYNLENLTKQLQEYLSPENAHKIQIEILEKELSSLAQETEELQKKATQTLAKAQQVNAESERT 80

                           90
                   ....*....|....*....
gi 578836003  2272 LGHAKTLLAAIRAVDRTLS 2290
Cdd:pfam06008   81 LGHAKELAEAIKNLIDNIK 99
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1438-1486 3.21e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 60.06  E-value: 3.21e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578836003  1438 CGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFPNCRPCDC 1486
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1577-1625 4.84e-11

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 59.67  E-value: 4.84e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578836003  1577 CDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTFSLDAANPKGC 1625
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 540-583 3.15e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 57.36  E-value: 3.15e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 578836003  540 PCQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPL 583
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 676-718 8.21e-10

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 56.21  E-value: 8.21e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 578836003  676 PCHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCVPGAYNFP 718
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1576-1626 1.17e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.82  E-value: 1.17e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 578836003 1576 PCDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTFSlDAANPKGCT 1626
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYG-LPSQGGGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 2069-2113 1.24e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.82  E-value: 1.24e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 578836003 2069 PCAC-GPAAEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQG 2113
Cdd:cd00055     1 PCDCnGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQG 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 587-634 1.29e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 55.44  E-value: 1.29e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578836003   587 CGCSPAGTLPEGCD-EAGRCLCQPEFAGPHCDRCRPGYHGFPNCQACTC 634
Cdd:pfam00053    1 CDCNPHGSLSDTCDpETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1437-1479 1.48e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 55.44  E-value: 1.48e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 578836003 1437 PCGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFP 1479
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
541-582 2.48e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 54.62  E-value: 2.48e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 578836003    541 CQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFP 582
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 541-589 2.72e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 54.67  E-value: 2.72e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578836003   541 CQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPLCQLCGC 589
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
2070-2114 2.93e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 54.62  E-value: 2.93e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 578836003   2070 CACGPA-AEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQGC 2114
Cdd:smart00180    1 CDCDPGgSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1528-1579 4.66e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.90  E-value: 4.66e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 578836003  1528 CNCSGPGIqelTDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYPRCRPCDC 1579
Cdd:pfam00053    1 CDCNPHGS---LSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1577-1615 5.59e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 53.85  E-value: 5.59e-09
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 578836003   1577 CDCHEAGTAPGVCDPLTGQCYCKENVQGPKCDQCSLGTF 1615
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYY 39
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
2023-2065 7.14e-09

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 53.47  E-value: 7.14e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 578836003   2023 CDCTPCGT--EACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGCG 2065
Cdd:smart00180    1 CDCDPGGSasGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGPPG 45
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1968-2021 7.72e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.51  E-value: 7.72e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 578836003 1968 PCDCSGNGDPNllfSDCDPLTGACRgCLRHTTGPRCEICAPGFYGNALLPGNCT 2021
Cdd:cd00055     1 PCDCNGHGSLS---GQCDPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGGCQ 50
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 2023-2067 7.83e-09

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.51  E-value: 7.83e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 578836003  2023 CDCTPCGT--EACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGCGGC 2067
Cdd:pfam00053    1 CDCNPHGSlsDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQ 47
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 2022-2068 8.68e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.13  E-value: 8.68e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 578836003 2022 RCDCTPCGT--EACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGCG-GCR 2068
Cdd:cd00055     1 PCDCNGHGSlsGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGgGCQ 50
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1528-1572 9.48e-09

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 53.13  E-value: 9.48e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 578836003 1528 CNCSGPGIQeltDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYP 1572
Cdd:cd00055     2 CDCNGHGSL---SGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLP 43
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 2070-2117 1.04e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 53.13  E-value: 1.04e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578836003  2070 CACGP-AAEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQGCRRC 2117
Cdd:pfam00053    1 CDCNPhGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
494-541 1.05e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 53.08  E-value: 1.05e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*...
gi 578836003    494 CDCSAAGTQGNACrkDPRVGRCLCKPNFQGTHCELCAPGFYGPGCQPC 541
Cdd:smart00180    1 CDCDPGGSASGTC--DPDTGQCECKPNVTGRRCDRCAPGYYGDGPPGC 46
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1438-1479 1.84e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 52.31  E-value: 1.84e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 578836003   1438 CGCHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFP 1479
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 677-725 1.87e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 52.36  E-value: 1.87e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578836003   677 CHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCVPGAYNFPYCEAGSC 725
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1528-1572 1.99e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 52.31  E-value: 1.99e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 578836003   1528 CNCSGPGIQeltDPTCDTDSGQCKCRPNVTGRRCDTCSPGFHGYP 1572
Cdd:smart00180    1 CDCDPGGSA---SGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
677-719 2.50e-08

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 51.93  E-value: 2.50e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 578836003    677 CHCSAEGSLHAACDPRSGQCSCRPRVTGLRCDTCVPGAYNFPY 719
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDGP 43
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 494-543 5.47e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 51.20  E-value: 5.47e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 578836003  494 CDCSAAGTQGNACrkDPRVGRCLCKPNFQGTHCELCAPGFYGPGCQPCQC 543
Cdd:cd00055     2 CDCNGHGSLSGQC--DPGTGQCECKPNTTGRRCDRCAPGYYGLPSQGGGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 587-627 6.40e-08

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 50.82  E-value: 6.40e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 578836003  587 CGCSPAGTLPEGCD-EAGRCLCQPEFAGPHCDRCRPGYHGFP 627
Cdd:cd00055     2 CDCNGHGSLSGQCDpGTGQCECKPNTTGRRCDRCAPGYYGLP 43
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 494-543 6.43e-08

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.81  E-value: 6.43e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 578836003   494 CDCSAAGTQGNACrkDPRVGRCLCKPNFQGTHCELCAPGFYG-PGCQPCQC 543
Cdd:pfam00053    1 CDCNPHGSLSDTC--DPETGQCLCKPGVTGRHCDRCKPGYYGlPSDPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 632-679 1.00e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 50.43  E-value: 1.00e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 578836003   632 CTCDPRGALDQLC-GAGGLCRCRPGYTGTACQECSPGFHGFPSCVPCHC 679
Cdd:pfam00053    1 CDCNPHGSLSDTCdPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 775-827 3.07e-07

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 48.89  E-value: 3.07e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 578836003  775 RCSCDLRGTLGGvaECQPGTGQCFCKPHVCGQACASCKDGFFGlDQADYFGCR 827
Cdd:cd00055     1 PCDCNGHGSLSG--QCDPGTGQCECKPNTTGRRCDRCAPGYYG-LPSQGGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
587-627 3.88e-07

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 48.46  E-value: 3.88e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 578836003    587 CGCSPAGTLPEGCD-EAGRCLCQPEFAGPHCDRCRPGYHGFP 627
Cdd:smart00180    1 CDCDPGGSASGTCDpDTGQCECKPNVTGRRCDRCAPGYYGDG 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1969-2019 5.56e-07

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 48.12  E-value: 5.56e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 578836003  1969 CDCSGNGDPNllfSDCDPLTGACRgCLRHTTGPRCEICAPGFYGNALLPGN 2019
Cdd:pfam00053    1 CDCNPHGSLS---DTCDPETGQCL-CKPGVTGRHCDRCKPGYYGLPSDPPQ 47
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 776-826 1.15e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 47.35  E-value: 1.15e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 578836003   776 CSCDLRGTLGGvaECQPGTGQCFCKPHVCGQACASCKDGFFGLDQADYFGC 826
Cdd:pfam00053    1 CDCNPHGSLSD--TCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
776-817 1.98e-06

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 46.54  E-value: 1.98e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 578836003    776 CSCDLRGTLGGvaECQPGTGQCFCKPHVCGQACASCKDGFFG 817
Cdd:smart00180    1 CDCDPGGSASG--TCDPDTGQCECKPNVTGRRCDRCAPGYYG 40
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1913-1966 2.92e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 46.19  E-value: 2.92e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 578836003  1913 CPCPLSVPSNnfaEGCVLRGGrtQCLCKPGYAGASCERCAPGFFGNPLVLGSSC 1966
Cdd:pfam00053    1 CDCNPHGSLS---DTCDPETG--QCLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 828-867 4.93e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.42  E-value: 4.93e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 578836003  828 SCRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHY 867
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGTGQCECKPNTTGRRCDRCAPGYY 40
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1863-1899 5.13e-06

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 45.42  E-value: 5.13e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 578836003 1863 PCQCHGH---SDRCLPGSGVCVdCQHNTEGAHCERCQAGF 1899
Cdd:cd00055     1 PCDCNGHgslSGQCDPGTGQCE-CKPNTTGRRCDRCAPGY 39
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 1864-1910 8.25e-06

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 44.65  E-value: 8.25e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 578836003  1864 CQCHGH---SDRCLPGSGVCvDCQHNTEGAHCERCQAGFVSSRDDPSAPC 1910
Cdd:pfam00053    1 CDCNPHgslSDTCDPETGQC-LCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1913-1959 1.02e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 44.61  E-value: 1.02e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*..
gi 578836003   1913 CPCPlsvPSNNFAEGCVLRGGrtQCLCKPGYAGASCERCAPGFFGNP 1959
Cdd:smart00180    1 CDCD---PGGSASGTCDPDTG--QCECKPNVTGRRCDRCAPGYYGDG 42
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 429-473 1.12e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 44.27  E-value: 1.12e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 578836003   429 CNC-ESDFTDGTCEDLTGRCYCRPNFSGERCDVCAEGFTGFPSCYP 473
Cdd:pfam00053    1 CDCnPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYYGLPSDPP 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 428-470 1.20e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 44.27  E-value: 1.20e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 578836003  428 RCNCESDFT-DGTCEDLTGRCYCRPNFSGERCDVCAEGFTGFPS 470
Cdd:cd00055     1 PCDCNGHGSlSGQCDPGTGQCECKPNTTGRRCDRCAPGYYGLPS 44
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 299-347 1.27e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 44.27  E-value: 1.27e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 578836003  299 RCVCHGHADACDAKDPTDpfrLQCTCQHNTCGGTCDRCCPGFNQQPWKP 347
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGT---GQCECKPNTTGRRCDRCAPGYYGLPSQG 46
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 631-673 1.82e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 43.88  E-value: 1.82e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 578836003  631 ACTCDPRGALDQLCGAG-GLCRCRPGYTGTACQECSPGFHGFPS 673
Cdd:cd00055     1 PCDCNGHGSLSGQCDPGtGQCECKPNTTGRRCDRCAPGYYGLPS 44
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
829-867 2.37e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 43.45  E-value: 2.37e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 578836003    829 CRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHY 867
Cdd:smart00180    1 CDCDPGGSASGTCDPDTGQCECKPNVTGRRCDRCAPGYY 39
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 744-773 2.79e-05

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 43.50  E-value: 2.79e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 578836003   744 CMCRAHVEGPSCDRCKPGFWGLSPSNPEGC 773
Cdd:pfam00053   20 CLCKPGVTGRHCDRCKPGYYGLPSDPPQGC 49
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
429-469 4.32e-05

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 42.68  E-value: 4.32e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 578836003    429 CNCESDFT-DGTCEDLTGRCYCRPNFSGERCDVCAEGFTGFP 469
Cdd:smart00180    1 CDCDPGGSaSGTCDPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 1912-1967 9.21e-05

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 41.96  E-value: 9.21e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 578836003 1912 SCPCPlsvPSNNFAEGCVLRGGrtQCLCKPGYAGASCERCAPGFFGNPLVlGSSCQ 1967
Cdd:cd00055     1 PCDCN---GHGSLSGQCDPGTG--QCECKPNTTGRRCDRCAPGYYGLPSQ-GGGCQ 50
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1969-2013 1.46e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 41.14  E-value: 1.46e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*
gi 578836003   1969 CDCSGNGDpnlLFSDCDPLTGACRgCLRHTTGPRCEICAPGFYGN 2013
Cdd:smart00180    1 CDCDPGGS---ASGTCDPDTGQCE-CKPNVTGRRCDRCAPGYYGD 41
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
632-672 1.96e-04

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 40.76  E-value: 1.96e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 578836003    632 CTCDPRGALDQLC-GAGGLCRCRPGYTGTACQECSPGFHGFP 672
Cdd:smart00180    1 CDCDPGGSASGTCdPDTGQCECKPNVTGRRCDRCAPGYYGDG 42
TNFRSF16 cd13416
Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 ...
 1844-1913 3.18e-04

Tumor necrosis factor receptor superfamily member 16 (TNFRSF16), also known as p75 neurotrophin receptor (p75NTR) or CD271; TNFRSF16 (also known as nerve growth factor receptor (NGFR) or p75 neurotrophin receptor (p75NTR or p75(NTR)), CD271, Gp80-LNGFR) is a common receptor for both neurotrophins and proneurotrophins, and plays a diverse role in many tissues, including the nervous system. It has been shown to be expressed in various types of stem cells and has been used to prospectively isolate stem cells with different degrees of potency. p75NTR owes its signaling to the recruitment of intracellular binding proteins, leading to the activation of different signaling pathways. It binds nerve growth factor (NGF) and the complex can initiate a signaling cascade which has been associated with both neuronal apoptosis and neuronal survival of discrete populations of neurons, depending on the presence or absence of intracellular signaling molecules downstream of p75NTR (e.g. NF-kB, JNK, or p75NTR intracellular death domain). p75NTR can also bind NGF in concert with the neurotrophic tyrosine kinase receptor type 1 (TrkA) protein where it is thought to modulate the formation of the high-affinity neurotrophin binding complex. On melanoma cell, p75NTR is an immunosuppressive factor, induced by interferon (IFN)-gamma, and mediates down-regulation of melanoma antigens. It can interact with the aggregated form of amyloid beta (Abeta) peptides, and plays an important role in etiopathogenesis of Alzheimer's disease by influencing protein tau hyper-phosphorylation. p75(NTR) is involved in the formation and progression of retina diseases; its expression is induced in retinal pigment epithelium (RPE) cells and its knockdown rescues RPE cell proliferation activity and inhibits RPE apoptosis induced by hypoxia. It can therefore be a potential therapeutic target for RPE hypoxia or oxidative stress diseases.


Pssm-ID: 276921 [Multi-domain]  Cd Length: 159  Bit Score: 43.44  E-value: 3.18e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578836003 1844 ECAPGFYRDVKGlflGRCVPCQchghsdRCLPGSGVCVDCQHNTEgAHCERCQAGFVSSRDDPSAPCVSC 1913
Cdd:cd13416    79 ECAYGYYLDEDS---GTCEPCT------VCPPGQGVVQSCGPNQD-TVCEACPEGTYSDEDSSTDPCLPC 138
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 829-867 5.54e-04

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 39.64  E-value: 5.54e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 578836003   829 CRCDIGGALGQSCEPRTGVCRCRPNTQGPTCSEPARDHY 867
Cdd:pfam00053    1 CDCNPHGSLSDTCDPETGQCLCKPGVTGRHCDRCKPGYY 39
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
1864-1899 1.25e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 38.45  E-value: 1.25e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 578836003   1864 CQCHG---HSDRCLPGSGVCvDCQHNTEGAHCERCQAGF 1899
Cdd:smart00180    1 CDCDPggsASGTCDPDTGQC-ECKPNVTGRRCDRCAPGY 38
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 387-421 2.64e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 37.72  E-value: 2.64e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 578836003  387 YQGGGVCIdCQHHTTGVNCERCLPGFYRSPNHPLD 421
Cdd:cd00055    15 DPGTGQCE-CKPNTTGRRCDRCAPGYYGLPSQGGG 48
EGF_Lam smart00180
Laminin-type epidermal growth factor-like domai;
744-773 3.09e-03

Laminin-type epidermal growth factor-like domai;


Pssm-ID: 214543  Cd Length: 46  Bit Score: 37.29  E-value: 3.09e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 578836003    744 CMCRAHVEGPSCDRCKPGFWGlspSNPEGC 773
Cdd:smart00180   20 CECKPNVTGRRCDRCAPGYYG---DGPPGC 46
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 387-426 5.39e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.95  E-value: 5.39e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 578836003   387 YQGGGVCiDCQHHTTGVNCERCLPGFYRSPNhplDSPHVC 426
Cdd:pfam00053   14 DPETGQC-LCKPGVTGRHCDRCKPGYYGLPS---DPPQGC 49
Laminin_EGF pfam00053
Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.
 2117-2145 6.07e-03

Laminin EGF domain; This family is like pfam00008 but has 8 conserved cysteines instead of six.


Pssm-ID: 395007  Cd Length: 49  Bit Score: 36.56  E-value: 6.07e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 578836003  2117 CQCPG-----GRCDPHTGRCNCPPGLSGERCDTC 2145
Cdd:pfam00053    1 CDCNPhgslsDTCDPETGQCLCKPGVTGRHCDRC 34
EGF_Lam cd00055
Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous ...
 2116-2145 8.04e-03

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies


Pssm-ID: 238012  Cd Length: 50  Bit Score: 36.56  E-value: 8.04e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 578836003 2116 RCQCPG-----GRCDPHTGRCNCPPGLSGERCDTC 2145
Cdd:cd00055     1 PCDCNGhgslsGQCDPGTGQCECKPNTTGRRCDRC 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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