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Conserved domains on  [gi|578829786|ref|XP_006721545|]
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calmodulin-binding transcription activator 2 isoform X7 [Homo sapiens]

Protein Classification

TIG domain-containing protein( domain architecture ID 12027827)

TIG domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
347-427 5.06e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 57.07  E-value: 5.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829786   347 TITDFSPEWSYPEGGVKVLITGP-WTEAAEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPL-SASVL 424
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSnFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGIsSSPLT 81

                   ...
gi 578829786   425 FEY 427
Cdd:pfam01833   82 FTY 84
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
523-624 7.39e-09

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.04  E-value: 7.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829786  523 RGMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFrwNRQA-LSIPDS 601
Cdd:COG0666   152 DGNTPLHLAAANGNLEIVKLL------------LEAGADVNARDNDGETPLHLAAENGHLEIVKLLL--EAGAdVNAKDN 217
                          90       100
                  ....*....|....*....|...
gi 578829786  602 LGRLPLSVAHSRGHVRLARCLEE 624
Cdd:COG0666   218 DGKTALDLAAENGNLEIVKLLLE 240
 
Name Accession Description Interval E-value
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
347-427 5.06e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 57.07  E-value: 5.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829786   347 TITDFSPEWSYPEGGVKVLITGP-WTEAAEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPL-SASVL 424
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSnFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGIsSSPLT 81

                   ...
gi 578829786   425 FEY 427
Cdd:pfam01833   82 FTY 84
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
523-624 7.39e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.04  E-value: 7.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829786  523 RGMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFrwNRQA-LSIPDS 601
Cdd:COG0666   152 DGNTPLHLAAANGNLEIVKLL------------LEAGADVNARDNDGETPLHLAAENGHLEIVKLLL--EAGAdVNAKDN 217
                          90       100
                  ....*....|....*....|...
gi 578829786  602 LGRLPLSVAHSRGHVRLARCLEE 624
Cdd:COG0666   218 DGKTALDLAAENGNLEIVKLLLE 240
Ank_2 pfam12796
Ankyrin repeats (3 copies);
528-620 1.27e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 1.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829786   528 LHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLfrWNRQALSIPDSlGRLPL 607
Cdd:pfam12796    1 LHLAAKNGNLELVKLL------------LENGADANLQDKNGRTALHLAAKNGHLEIVKLL--LEHADVNLKDN-GRTAL 65
                           90
                   ....*....|...
gi 578829786   608 SVAHSRGHVRLAR 620
Cdd:pfam12796   66 HYAARSGHLEIVK 78
 
Name Accession Description Interval E-value
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
347-427 5.06e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 57.07  E-value: 5.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829786   347 TITDFSPEWSYPEGGVKVLITGP-WTEAAEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPL-SASVL 424
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSnFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGIsSSPLT 81

                   ...
gi 578829786   425 FEY 427
Cdd:pfam01833   82 FTY 84
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
523-624 7.39e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.04  E-value: 7.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829786  523 RGMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFrwNRQA-LSIPDS 601
Cdd:COG0666   152 DGNTPLHLAAANGNLEIVKLL------------LEAGADVNARDNDGETPLHLAAENGHLEIVKLLL--EAGAdVNAKDN 217
                          90       100
                  ....*....|....*....|...
gi 578829786  602 LGRLPLSVAHSRGHVRLARCLEE 624
Cdd:COG0666   218 DGKTALDLAAENGNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
523-624 2.04e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.89  E-value: 2.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829786  523 RGMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFrwNRQA-LSIPDS 601
Cdd:COG0666   119 DGETPLHLAAYNGNLEIVKLL------------LEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLL--EAGAdVNARDN 184
                          90       100
                  ....*....|....*....|...
gi 578829786  602 LGRLPLSVAHSRGHVRLARCLEE 624
Cdd:COG0666   185 DGETPLHLAAENGHLEIVKLLLE 207
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
524-622 1.28e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.57  E-value: 1.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829786  524 GMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFrwNRQA-LSIPDSL 602
Cdd:COG0666    87 GNTLLHAAARNGDLEIVKLL------------LEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL--EAGAdVNAQDND 152
                          90       100
                  ....*....|....*....|
gi 578829786  603 GRLPLSVAHSRGHVRLARCL 622
Cdd:COG0666   153 GNTPLHLAAANGNLEIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
528-620 1.27e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 1.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829786   528 LHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLfrWNRQALSIPDSlGRLPL 607
Cdd:pfam12796    1 LHLAAKNGNLELVKLL------------LENGADANLQDKNGRTALHLAAKNGHLEIVKLL--LEHADVNLKDN-GRTAL 65
                           90
                   ....*....|...
gi 578829786   608 SVAHSRGHVRLAR 620
Cdd:pfam12796   66 HYAARSGHLEIVK 78
Ank_2 pfam12796
Ankyrin repeats (3 copies);
524-588 2.16e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 38.17  E-value: 2.16e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578829786   524 GMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEvdPLNVDHFSCTPLMWACALGHLEAAVLL 588
Cdd:pfam12796   30 GRTALHLAAKNGHLEIVKLL------------LEHA--DVNLKDNGRTALHYAARSGHLEIVKLL 80
Ank_5 pfam13857
Ankyrin repeats (many copies);
560-610 2.45e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.94  E-value: 2.45e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 578829786   560 VDPLNVDHFSCTPLMWACALGHLEAAVLLFRwNRQALSIPDSLGRLPLSVA 610
Cdd:pfam13857    7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLA-YGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
524-588 6.00e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 6.00e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578829786   524 GMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLL 588
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLL------------LEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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