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Conserved domains on  [gi|578829778|ref|XP_006721541|]
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calmodulin-binding transcription activator 2 isoform X5 [Homo sapiens]

Protein Classification

calmodulin-binding transcription activator( domain architecture ID 12224848)

calmodulin-binding transcription activator may act as a tumor suppressor

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CG-1 smart01076
CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains ...
34-155 1.09e-67

CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains contain a predicted bipartite NLS and are named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


:

Pssm-ID: 198144  Cd Length: 118  Bit Score: 222.66  E-value: 1.09e-67
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829778     34 LPPERLRWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKY-RKDGYLWKKRKDGKTTREDHMKLKVQGM 112
Cdd:smart01076    1 LPEAKHRWLTPEEIAAILINFDKHTEWLTTSPPTRPKSGSLFLFNRKKLKYfRKDGYNWKKKKDGKTVREDHEKLKVGGI 80
                            90       100       110       120
                    ....*....|....*....|....*....|....*....|...
gi 578829778    113 EpvswqCLYGCYVHSSIVPTFHRRCYWLLQNPDIVLVHYLNVP 155
Cdd:smart01076   81 E-----CLHCYYAHSEINPTFHRRCYWLLQNPDIVLVHYLNVP 118
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
539-619 6.05e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


:

Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 57.07  E-value: 6.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829778   539 TITDFSPEWSYPEGGVKVLITGP-WTEAAEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPL-SASVL 616
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSnFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGIsSSPLT 81

                   ...
gi 578829778   617 FEY 619
Cdd:pfam01833   82 FTY 84
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
715-816 9.08e-09

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.04  E-value: 9.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829778  715 RGMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFrwNRQA-LSIPDS 793
Cdd:COG0666   152 DGNTPLHLAAANGNLEIVKLL------------LEAGADVNARDNDGETPLHLAAENGHLEIVKLLL--EAGAdVNAKDN 217
                          90       100
                  ....*....|....*....|...
gi 578829778  794 LGRLPLSVAHSRGHVRLARCLEE 816
Cdd:COG0666   218 DGKTALDLAAENGNLEIVKLLLE 240
 
Name Accession Description Interval E-value
CG-1 smart01076
CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains ...
34-155 1.09e-67

CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains contain a predicted bipartite NLS and are named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 198144  Cd Length: 118  Bit Score: 222.66  E-value: 1.09e-67
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829778     34 LPPERLRWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKY-RKDGYLWKKRKDGKTTREDHMKLKVQGM 112
Cdd:smart01076    1 LPEAKHRWLTPEEIAAILINFDKHTEWLTTSPPTRPKSGSLFLFNRKKLKYfRKDGYNWKKKKDGKTVREDHEKLKVGGI 80
                            90       100       110       120
                    ....*....|....*....|....*....|....*....|...
gi 578829778    113 EpvswqCLYGCYVHSSIVPTFHRRCYWLLQNPDIVLVHYLNVP 155
Cdd:smart01076   81 E-----CLHCYYAHSEINPTFHRRCYWLLQNPDIVLVHYLNVP 118
CG-1 pfam03859
CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues ...
40-154 3.46e-52

CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 461077  Cd Length: 114  Bit Score: 178.62  E-value: 3.46e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829778    40 RWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKY-RKDGYLWKKRKDGKTTREDHMKLKVQGMEpvswq 118
Cdd:pfam03859    3 RWLKPQEILAILLNYDPYGFCITPEPPPRPPSGSLFLFDRKKLRYfRKDGHNWRKKKDGKTVREDHEKLKVGGVE----- 77
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 578829778   119 CLYGCYVHSSIVPTFHRRCYWLLQNP-DIVLVHYLNV 154
Cdd:pfam03859   78 AIHCYYAHSEDNPTFQRRIYWLLDSDyHIVLVHYLNV 114
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
539-619 6.05e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 57.07  E-value: 6.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829778   539 TITDFSPEWSYPEGGVKVLITGP-WTEAAEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPL-SASVL 616
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSnFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGIsSSPLT 81

                   ...
gi 578829778   617 FEY 619
Cdd:pfam01833   82 FTY 84
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
715-816 9.08e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.04  E-value: 9.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829778  715 RGMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFrwNRQA-LSIPDS 793
Cdd:COG0666   152 DGNTPLHLAAANGNLEIVKLL------------LEAGADVNARDNDGETPLHLAAENGHLEIVKLLL--EAGAdVNAKDN 217
                          90       100
                  ....*....|....*....|...
gi 578829778  794 LGRLPLSVAHSRGHVRLARCLEE 816
Cdd:COG0666   218 DGKTALDLAAENGNLEIVKLLLE 240
Ank_2 pfam12796
Ankyrin repeats (3 copies);
720-812 1.52e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 1.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829778   720 LHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLfrWNRQALSIPDSlGRLPL 799
Cdd:pfam12796    1 LHLAAKNGNLELVKLL------------LENGADANLQDKNGRTALHLAAKNGHLEIVKLL--LEHADVNLKDN-GRTAL 65
                           90
                   ....*....|...
gi 578829778   800 SVAHSRGHVRLAR 812
Cdd:pfam12796   66 HYAARSGHLEIVK 78
 
Name Accession Description Interval E-value
CG-1 smart01076
CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains ...
34-155 1.09e-67

CG-1 domains are highly conserved domains of about 130 amino-acid residues; The domains contain a predicted bipartite NLS and are named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 198144  Cd Length: 118  Bit Score: 222.66  E-value: 1.09e-67
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829778     34 LPPERLRWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKY-RKDGYLWKKRKDGKTTREDHMKLKVQGM 112
Cdd:smart01076    1 LPEAKHRWLTPEEIAAILINFDKHTEWLTTSPPTRPKSGSLFLFNRKKLKYfRKDGYNWKKKKDGKTVREDHEKLKVGGI 80
                            90       100       110       120
                    ....*....|....*....|....*....|....*....|...
gi 578829778    113 EpvswqCLYGCYVHSSIVPTFHRRCYWLLQNPDIVLVHYLNVP 155
Cdd:smart01076   81 E-----CLHCYYAHSEINPTFHRRCYWLLQNPDIVLVHYLNVP 118
CG-1 pfam03859
CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues ...
40-154 3.46e-52

CG-1 domain; CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs.


Pssm-ID: 461077  Cd Length: 114  Bit Score: 178.62  E-value: 3.46e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829778    40 RWNTNEEIASYLITFEKHDEWLSCAPKTRPQNGSIILYNRKKVKY-RKDGYLWKKRKDGKTTREDHMKLKVQGMEpvswq 118
Cdd:pfam03859    3 RWLKPQEILAILLNYDPYGFCITPEPPPRPPSGSLFLFDRKKLRYfRKDGHNWRKKKDGKTVREDHEKLKVGGVE----- 77
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 578829778   119 CLYGCYVHSSIVPTFHRRCYWLLQNP-DIVLVHYLNV 154
Cdd:pfam03859   78 AIHCYYAHSEDNPTFQRRIYWLLDSDyHIVLVHYLNV 114
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
539-619 6.05e-10

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 57.07  E-value: 6.05e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829778   539 TITDFSPEWSYPEGGVKVLITGP-WTEAAEHYSCVFDHIAVPASLVQPGVLRCYCPAHEVGLVSLQVAGREGPL-SASVL 616
Cdd:pfam01833    2 VITSISPSSGPASGGTTITITGSnFGTDSSDLKVTIGGTPCTVISVSSTTIVCTTPPGTSGLVNVSVTVGGGGIsSSPLT 81

                   ...
gi 578829778   617 FEY 619
Cdd:pfam01833   82 FTY 84
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
715-816 9.08e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 58.04  E-value: 9.08e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829778  715 RGMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFrwNRQA-LSIPDS 793
Cdd:COG0666   152 DGNTPLHLAAANGNLEIVKLL------------LEAGADVNARDNDGETPLHLAAENGHLEIVKLLL--EAGAdVNAKDN 217
                          90       100
                  ....*....|....*....|...
gi 578829778  794 LGRLPLSVAHSRGHVRLARCLEE 816
Cdd:COG0666   218 DGKTALDLAAENGNLEIVKLLLE 240
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
715-816 2.50e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.89  E-value: 2.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829778  715 RGMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFrwNRQA-LSIPDS 793
Cdd:COG0666   119 DGETPLHLAAYNGNLEIVKLL------------LEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLL--EAGAdVNARDN 184
                          90       100
                  ....*....|....*....|...
gi 578829778  794 LGRLPLSVAHSRGHVRLARCLEE 816
Cdd:COG0666   185 DGETPLHLAAENGHLEIVKLLLE 207
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
716-814 1.56e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.57  E-value: 1.56e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829778  716 GMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLFrwNRQA-LSIPDSL 794
Cdd:COG0666    87 GNTLLHAAARNGDLEIVKLL------------LEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL--EAGAdVNAQDND 152
                          90       100
                  ....*....|....*....|
gi 578829778  795 GRLPLSVAHSRGHVRLARCL 814
Cdd:COG0666   153 GNTPLHLAAANGNLEIVKLL 172
Ank_2 pfam12796
Ankyrin repeats (3 copies);
720-812 1.52e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 1.52e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578829778   720 LHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLLfrWNRQALSIPDSlGRLPL 799
Cdd:pfam12796    1 LHLAAKNGNLELVKLL------------LENGADANLQDKNGRTALHLAAKNGHLEIVKLL--LEHADVNLKDN-GRTAL 65
                           90
                   ....*....|...
gi 578829778   800 SVAHSRGHVRLAR 812
Cdd:pfam12796   66 HYAARSGHLEIVK 78
Ank_2 pfam12796
Ankyrin repeats (3 copies);
716-780 2.59e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 38.17  E-value: 2.59e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578829778   716 GMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEvdPLNVDHFSCTPLMWACALGHLEAAVLL 780
Cdd:pfam12796   30 GRTALHLAAKNGHLEIVKLL------------LEHA--DVNLKDNGRTALHYAARSGHLEIVKLL 80
Ank_5 pfam13857
Ankyrin repeats (many copies);
752-802 2.92e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.94  E-value: 2.92e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 578829778   752 VDPLNVDHFSCTPLMWACALGHLEAAVLLFRwNRQALSIPDSLGRLPLSVA 802
Cdd:pfam13857    7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLA-YGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
716-780 7.15e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 7.15e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578829778   716 GMSLLHLAAAQGYARLIETLsqwrsvetgsldLEQEVDPLNVDHFSCTPLMWACALGHLEAAVLL 780
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLL------------LEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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