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Conserved domains on  [gi|578828380|ref|XP_006721054|]
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intraflagellar transport protein 140 homolog isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 18610525)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 834-1082 8.55e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.51  E-value: 8.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  834 RALREAEQEPELEARVAVLATQLGMLEDAEQLYRKCKRHD--------LLNKFYQAAGRWQEALQVAE-----HHDRVHL 900
Cdd:COG2956    67 KLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDpddaealrLLAEIYEQEGDWEKAIEVLErllklGPENAHA 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  901 rstYHRYAGHLEASADCSRALSYYEKsdthrfevprMLSEDLPSLELYVNKmkdktlwrwwAQYLESQGEMDAALHYYel 980
Cdd:COG2956   147 ---YCELAELYLEQGDYDEAIEALEK----------ALKLDPDCARALLLL----------AELYLEQGDYEEAIAAL-- 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  981 ardhfslvrihcfqgnvQKAAQIANEtgNLAASYHLARQYESQEEVGQAVHFYTRAQAfknairlckENGLDDQLMNLAL 1060
Cdd:COG2956   202 -----------------ERALEQDPD--YLPALPRLAELYEKLGDPEEALELLRKALE---------LDPSDDLLLALAD 253

                         250       260
                  ....*....|....*....|..
gi 578828380 1061 LSSPEDMIEAARYYEEKGVQMD 1082
Cdd:COG2956   254 LLERKEGLEAALALLERQLRRH 275
WD40 COG2319
WD40 repeat [General function prediction only];
24-133 1.84e-07

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 1.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380   24 HPVHPFLAVAY-------ISTTSTGSVDIY-LEQGECVPdTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQ 95
Cdd:COG2319   286 GHSGGVNSVAFspdgkllASGSDDGTVRLWdLATGKLLR-TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 578828380   96 HTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLD 133
Cdd:COG2319   365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 973-1227 2.23e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.64  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  973 AALHYYELARDHFslvrihcFQGNVQKAAQ-----IANETGNLAASYHLARQYESQEEVGQAVHFYtraqafKNAIRLCK 1047
Cdd:COG2956     7 AALGWYFKGLNYL-------LNGQPDKAIDlleeaLELDPETVEAHLALGNLYRRRGEYDRAIRIH------QKLLERDP 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380 1048 ENglDDQLMNLAllsspedmieaaryyeekgvqmdravMLYHKAGHFSKALELafatqqfvALQLIAEDLDetsDPALLA 1127
Cdd:COG2956    74 DR--AEALLELA--------------------------QDYLKAGLLDRAEEL--------LEKLLELDPD---DAEALR 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380 1128 RCSDFFIEHSQYERAVELLLAARKYQealqlclGQNMSITEEMAEKMTVAKDssdlPEESRRELLE--QIADCCMR---- 1201
Cdd:COG2956   115 LLAEIYEQEGDWEKAIEVLERLLKLG-------PENAHAYCELAELYLEQGD----YDEAIEALEKalKLDPDCARalll 183

                         250       260
                  ....*....|....*....|....*.
gi 578828380 1202 QGSYHLATKKYTQAgnkLKAMRALLK 1227
Cdd:COG2956   184 LAELYLEQGDYEEA---IAALERALE 206
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 834-1082 8.55e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.51  E-value: 8.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  834 RALREAEQEPELEARVAVLATQLGMLEDAEQLYRKCKRHD--------LLNKFYQAAGRWQEALQVAE-----HHDRVHL 900
Cdd:COG2956    67 KLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDpddaealrLLAEIYEQEGDWEKAIEVLErllklGPENAHA 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  901 rstYHRYAGHLEASADCSRALSYYEKsdthrfevprMLSEDLPSLELYVNKmkdktlwrwwAQYLESQGEMDAALHYYel 980
Cdd:COG2956   147 ---YCELAELYLEQGDYDEAIEALEK----------ALKLDPDCARALLLL----------AELYLEQGDYEEAIAAL-- 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  981 ardhfslvrihcfqgnvQKAAQIANEtgNLAASYHLARQYESQEEVGQAVHFYTRAQAfknairlckENGLDDQLMNLAL 1060
Cdd:COG2956   202 -----------------ERALEQDPD--YLPALPRLAELYEKLGDPEEALELLRKALE---------LDPSDDLLLALAD 253

                         250       260
                  ....*....|....*....|..
gi 578828380 1061 LSSPEDMIEAARYYEEKGVQMD 1082
Cdd:COG2956   254 LLERKEGLEAALALLERQLRRH 275
WD40 COG2319
WD40 repeat [General function prediction only];
24-133 1.84e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 1.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380   24 HPVHPFLAVAY-------ISTTSTGSVDIY-LEQGECVPdTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQ 95
Cdd:COG2319   286 GHSGGVNSVAFspdgkllASGSDDGTVRLWdLATGKLLR-TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 578828380   96 HTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLD 133
Cdd:COG2319   365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-229 3.97e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 3.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380   15 AGSPSFISWHPVHPFLAvayiSTTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDK 93
Cdd:cd00200    51 TGPVRDVAASADGTYLA----SGSSDKTIRLWdLETGECV-RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380   94 EQHTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLDQrGRVQGTpLLKHEygKHLTHCIFRlpPPGEDLVqlakaa 173
Cdd:cd00200   126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT-GKCVAT-LTGHT--GEVNSVAFS--PDGEKLL------ 193

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578828380  174 VSGDEKALDMFNwkkSSSGSLLK-MGSHE-----------GLLFFVSLMDGTVHYVD-EKGKTTQVVSA 229
Cdd:cd00200   194 SSSSDGTIKLWD---LSTGKCLGtLRGHEngvnsvafspdGYLLASGSEDGTIRVWDlRTGECVQTLSG 259
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 973-1227 2.23e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.64  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  973 AALHYYELARDHFslvrihcFQGNVQKAAQ-----IANETGNLAASYHLARQYESQEEVGQAVHFYtraqafKNAIRLCK 1047
Cdd:COG2956     7 AALGWYFKGLNYL-------LNGQPDKAIDlleeaLELDPETVEAHLALGNLYRRRGEYDRAIRIH------QKLLERDP 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380 1048 ENglDDQLMNLAllsspedmieaaryyeekgvqmdravMLYHKAGHFSKALELafatqqfvALQLIAEDLDetsDPALLA 1127
Cdd:COG2956    74 DR--AEALLELA--------------------------QDYLKAGLLDRAEEL--------LEKLLELDPD---DAEALR 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380 1128 RCSDFFIEHSQYERAVELLLAARKYQealqlclGQNMSITEEMAEKMTVAKDssdlPEESRRELLE--QIADCCMR---- 1201
Cdd:COG2956   115 LLAEIYEQEGDWEKAIEVLERLLKLG-------PENAHAYCELAELYLEQGD----YDEAIEALEKalKLDPDCARalll 183

                         250       260
                  ....*....|....*....|....*.
gi 578828380 1202 QGSYHLATKKYTQAgnkLKAMRALLK 1227
Cdd:COG2956   184 LAELYLEQGDYEEA---IAALERALE 206
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 951-1233 4.72e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.61  E-value: 4.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380   951 KMKDK-TLWRWWAQYLESQGEMDAALHYYELAR----DHF----SLVRIHCFQGNVQKAAQ-----IANETGNLAASYHL 1016
Cdd:TIGR02917  460 KQPDNaSLHNLLGAIYLGKGDLAKAREAFEKALsiepDFFpaaaNLARIDIQEGNPDDAIQrfekvLTIDPKNLRAILAL 539

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  1017 ARQYESQEEVGQAVHFYTRAQAfknairlckengLDDQLMNLALLsspedmieAARYYEEKGvQMDRAVMLyhkaghFSK 1096
Cdd:TIGR02917  540 AGLYLRTGNEEEAVAWLEKAAE------------LNPQEIEPALA--------LAQYYLGKG-QLKKALAI------LNE 592

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  1097 ALELAFATQQFVAL----QLIAEDLDE--TSDPALLARCSDFFIEHSQ----YERAVELLLAARKYQEALQL----CLGQ 1162
Cdd:TIGR02917  593 AADAAPDSPEAWLMlgraQLAAGDLNKavSSFKKLLALQPDSALALLLladaYAVMKNYAKAITSLKRALELkpdnTEAQ 672

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  1163 NMSITEEMAEKMTV-AKDSSDLPEESRRE---LLEQIADCCMRQGSYHLATKKYTQA-------GNKLKAMRALLKSGDT 1231
Cdd:TIGR02917  673 IGLAQLLLAAKRTEsAKKIAKSLQKQHPKaalGFELEGDLYLRQKDYPAAIQAYRKAlkrapssQNAIKLHRALLASGNT 752


                   ..
gi 578828380  1232 EK 1233
Cdd:TIGR02917  753 AE 754
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 102-130 6.29e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 6.29e-03
                            10        20
                    ....*....|....*....|....*....
gi 578828380    102 HTADITVLRWSPSGNCLLSGDRLGVLLLW 130
Cdd:smart00320   11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 63-112 7.70e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 7.70e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 578828380    63 RVASLCWHPTRLVLAVGWETGEVTVFNKQD-KEQHTMPlTHTADITVLRWS 112
Cdd:pfam12894   40 EVTSLAWRPDGKLLAVGYSDGTVRLLDAENgKIVHHFS-AGSDLITCLGWG 89
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 834-1082 8.55e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.51  E-value: 8.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  834 RALREAEQEPELEARVAVLATQLGMLEDAEQLYRKCKRHD--------LLNKFYQAAGRWQEALQVAE-----HHDRVHL 900
Cdd:COG2956    67 KLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDpddaealrLLAEIYEQEGDWEKAIEVLErllklGPENAHA 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  901 rstYHRYAGHLEASADCSRALSYYEKsdthrfevprMLSEDLPSLELYVNKmkdktlwrwwAQYLESQGEMDAALHYYel 980
Cdd:COG2956   147 ---YCELAELYLEQGDYDEAIEALEK----------ALKLDPDCARALLLL----------AELYLEQGDYEEAIAAL-- 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  981 ardhfslvrihcfqgnvQKAAQIANEtgNLAASYHLARQYESQEEVGQAVHFYTRAQAfknairlckENGLDDQLMNLAL 1060
Cdd:COG2956   202 -----------------ERALEQDPD--YLPALPRLAELYEKLGDPEEALELLRKALE---------LDPSDDLLLALAD 253

                         250       260
                  ....*....|....*....|..
gi 578828380 1061 LSSPEDMIEAARYYEEKGVQMD 1082
Cdd:COG2956   254 LLERKEGLEAALALLERQLRRH 275
WD40 COG2319
WD40 repeat [General function prediction only];
24-133 1.84e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 55.30  E-value: 1.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380   24 HPVHPFLAVAY-------ISTTSTGSVDIY-LEQGECVPdTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQ 95
Cdd:COG2319   286 GHSGGVNSVAFspdgkllASGSDDGTVRLWdLATGKLLR-TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 578828380   96 HTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLD 133
Cdd:COG2319   365 LRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 850-1149 2.30e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.96  E-value: 2.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  850 AVLATQLGMLEDAEQLYRKckrhdllNKFYQAAGRWQEALQVAEHHDRVHLR-STYHRYAGHLEasadcsRALSYYEKsd 928
Cdd:COG2956     3 LPVAAALGWYFKGLNYLLN-------GQPDKAIDLLEEALELDPETVEAHLAlGNLYRRRGEYD------RAIRIHQK-- 67

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  929 thrfevprMLSEDLPSLELYVNKmkdktlwrwwAQYLESQGEMDAALHYYELARD--------HFSLVRIHCFQGNVQKA 1000
Cdd:COG2956    68 --------LLERDPDRAEALLEL----------AQDYLKAGLLDRAEELLEKLLEldpddaeaLRLLAEIYEQEGDWEKA 129

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380 1001 AQIANE-----TGNLAASYHLARQYESQEEVGQAVHFYTRA-QAFKNAIRLckenglddqLMNLA-LLSSPEDMIEAARY 1073
Cdd:COG2956   130 IEVLERllklgPENAHAYCELAELYLEQGDYDEAIEALEKAlKLDPDCARA---------LLLLAeLYLEQGDYEEAIAA 200

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578828380 1074 YEEKGVQMDRAVMLYHKAGHFSKALElafatQQFVALQLIAEDLDETSDPALLARCSDFFIEHSQYERAVELLLAA 1149
Cdd:COG2956   201 LERALEQDPDYLPALPRLAELYEKLG-----DPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALALLERQ 271
WD40 COG2319
WD40 repeat [General function prediction only];
16-139 2.97e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 2.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380   16 GSPSFISWHPVHPFLAvayiSTTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKE 94
Cdd:COG2319   247 GSVRSVAFSPDGRLLA----SGSADGTVRLWdLATGELL-RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK 321

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 578828380   95 QHTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLDQRGRVQ 139
Cdd:COG2319   322 LLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLR 366
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-229 3.97e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 3.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380   15 AGSPSFISWHPVHPFLAvayiSTTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDK 93
Cdd:cd00200    51 TGPVRDVAASADGTYLA----SGSSDKTIRLWdLETGECV-RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380   94 EQHTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLDQrGRVQGTpLLKHEygKHLTHCIFRlpPPGEDLVqlakaa 173
Cdd:cd00200   126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT-GKCVAT-LTGHT--GEVNSVAFS--PDGEKLL------ 193

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578828380  174 VSGDEKALDMFNwkkSSSGSLLK-MGSHE-----------GLLFFVSLMDGTVHYVD-EKGKTTQVVSA 229
Cdd:cd00200   194 SSSSDGTIKLWD---LSTGKCLGtLRGHEngvnsvafspdGYLLASGSEDGTIRVWDlRTGECVQTLSG 259
WD40 COG2319
WD40 repeat [General function prediction only];
21-140 3.17e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 3.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380   21 ISWHPVHPFLAVAyistTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQHTMP 99
Cdd:COG2319   210 VAFSPDGKLLASG----SADGTVRLWdLATGKLL-RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL 284

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 578828380  100 LTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLDQRGRVQG 140
Cdd:COG2319   285 TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 325
WD40 COG2319
WD40 repeat [General function prediction only];
63-133 8.08e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 8.08e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578828380   63 RVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQHTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLD 133
Cdd:COG2319   206 AVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
14-139 9.44e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 9.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380   14 AAGSPSFISWHPVHPFLAVAY-------ISTTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRLVLAVGWETGEV 85
Cdd:COG2319   108 ATGLLLRTLTGHTGAVRSVAFspdgktlASGSADGTVRLWdLATGKLL-RTLTGHSGAVTSVAFSPDGKLLASGSDDGTV 186

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 578828380   86 TVFNKQD-KEQHTMPlTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLDQRGRVQ 139
Cdd:COG2319   187 RLWDLATgKLLRTLT-GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 829-1091 9.97e-05

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 46.06  E-value: 9.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  829 HARGARALRE------AEQEPELEARVAVLATQL----GMLEDA----EQLYRKCKRH----DLLNKFYQAAGRWQEALQ 890
Cdd:COG3071    61 QALGDYERRDeylaqaLELAPEAELAVLLTRAELlldqGQAEQAlatlEALRAGAPRHpqvlRLLLQAYRQLGDWEELLE 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  891 VAE------HHDRVHLRSTYHR-YAGHLEASADCSRALsyyeksdthrfevpRMLSEDLPSLElyvnkMKDKTLWRWWAQ 963
Cdd:COG3071   141 LLPalrkhkALSAEEAQALERRaYLGLLRQAARDAEAL--------------KALWKALPRAE-----RRDPELAAAYAR 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  964 YLESQGEMDAALHYYELARDHF---SLVRI--HCFQGNVQKAAQIAN-----ETGNLAASYHLARQYESQEEVGQAVHFY 1033
Cdd:COG3071   202 ALIALGDHDEAERLLREALKRQwdpRLVRLygRLQGGDPAKQLKRAEkwlkkHPNDPDLLLALGRLCLRNQLWGKAREYL 281

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 578828380 1034 TRAqafknairlckenglddqlmnLALLSSPEDMIEAARYYEEKGvQMDRAVMLYHKA 1091
Cdd:COG3071   282 EAA---------------------LALRPSAEAYAELARLLEQLG-DPEEAAEHYRKA 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 19-121 1.60e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.40  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380   19 SFISWHPVHPFLavayISTTSTGSVDIY-LEQGECVpDTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQHT 97
Cdd:cd00200   181 NSVAFSPDGEKL----LSSSSDGTIKLWdLSTGKCL-GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ 255

                          90       100
                  ....*....|....*....|....*
gi 578828380   98 MpLT-HTADITVLRWSPSGNCLLSG 121
Cdd:cd00200   256 T-LSgHTNSVTSLAWSPDGKRLASG 279
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 785-894 2.42e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.87  E-value: 2.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  785 IGDMDEAFKSI-KLIKSE----AVWENMARMCVKTQRLDVAKVCLgnmghargARALREAEQEPELEARVAVLATQLGML 859
Cdd:COG4783    17 AGDYDEAEALLeKALELDpdnpEAFALLGEILLQLGDLDEAIVLL--------HEALELDPDEPEARLNLGLALLKAGDY 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 578828380  860 EDAEQLYRKCKRHD--------LLNKFYQAAGRWQEALQVAEH 894
Cdd:COG4783    89 DEALALLEKALKLDpehpeaylRLARAYRALGRPDEAIAALEK 131
WD40 COG2319
WD40 repeat [General function prediction only];
35-139 3.36e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.90  E-value: 3.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380   35 ISTTSTGSVDIY-LEQGECVPdTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDKEQHTMPLTHTADITVLRWSP 113
Cdd:COG2319    94 ASASADGTVRLWdLATGLLLR-TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP 172

                          90       100
                  ....*....|....*....|....*.
gi 578828380  114 SGNCLLSGDRLGVLLLWRLDQRGRVQ 139
Cdd:COG2319   173 DGKLLASGSDDGTVRLWDLATGKLLR 198
WD40 COG2319
WD40 repeat [General function prediction only];
14-139 4.40e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.52  E-value: 4.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380   14 AAGSPSFISWHPVHPFLAVAYISTTSTGSVDIYLEQGECVPDTHVERPFRVASLCWHPTRLVLAVGWETGEVTVFNKQDK 93
Cdd:COG2319    31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG 110

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 578828380   94 EQHTMPLTHTADITVLRWSPSGNCLLSGDRLGVLLLWRLDQRGRVQ 139
Cdd:COG2319   111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR 156
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 973-1227 2.23e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 41.64  E-value: 2.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  973 AALHYYELARDHFslvrihcFQGNVQKAAQ-----IANETGNLAASYHLARQYESQEEVGQAVHFYtraqafKNAIRLCK 1047
Cdd:COG2956     7 AALGWYFKGLNYL-------LNGQPDKAIDlleeaLELDPETVEAHLALGNLYRRRGEYDRAIRIH------QKLLERDP 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380 1048 ENglDDQLMNLAllsspedmieaaryyeekgvqmdravMLYHKAGHFSKALELafatqqfvALQLIAEDLDetsDPALLA 1127
Cdd:COG2956    74 DR--AEALLELA--------------------------QDYLKAGLLDRAEEL--------LEKLLELDPD---DAEALR 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380 1128 RCSDFFIEHSQYERAVELLLAARKYQealqlclGQNMSITEEMAEKMTVAKDssdlPEESRRELLE--QIADCCMR---- 1201
Cdd:COG2956   115 LLAEIYEQEGDWEKAIEVLERLLKLG-------PENAHAYCELAELYLEQGD----YDEAIEALEKalKLDPDCARalll 183

                         250       260
                  ....*....|....*....|....*.
gi 578828380 1202 QGSYHLATKKYTQAgnkLKAMRALLK 1227
Cdd:COG2956   184 LAELYLEQGDYEEA---IAALERALE 206
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 951-1233 4.72e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.61  E-value: 4.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380   951 KMKDK-TLWRWWAQYLESQGEMDAALHYYELAR----DHF----SLVRIHCFQGNVQKAAQ-----IANETGNLAASYHL 1016
Cdd:TIGR02917  460 KQPDNaSLHNLLGAIYLGKGDLAKAREAFEKALsiepDFFpaaaNLARIDIQEGNPDDAIQrfekvLTIDPKNLRAILAL 539

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  1017 ARQYESQEEVGQAVHFYTRAQAfknairlckengLDDQLMNLALLsspedmieAARYYEEKGvQMDRAVMLyhkaghFSK 1096
Cdd:TIGR02917  540 AGLYLRTGNEEEAVAWLEKAAE------------LNPQEIEPALA--------LAQYYLGKG-QLKKALAI------LNE 592

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  1097 ALELAFATQQFVAL----QLIAEDLDE--TSDPALLARCSDFFIEHSQ----YERAVELLLAARKYQEALQL----CLGQ 1162
Cdd:TIGR02917  593 AADAAPDSPEAWLMlgraQLAAGDLNKavSSFKKLLALQPDSALALLLladaYAVMKNYAKAITSLKRALELkpdnTEAQ 672

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  1163 NMSITEEMAEKMTV-AKDSSDLPEESRRE---LLEQIADCCMRQGSYHLATKKYTQA-------GNKLKAMRALLKSGDT 1231
Cdd:TIGR02917  673 IGLAQLLLAAKRTEsAKKIAKSLQKQHPKaalGFELEGDLYLRQKDYPAAIQAYRKAlkrapssQNAIKLHRALLASGNT 752


                   ..
gi 578828380  1232 EK 1233
Cdd:TIGR02917  753 AE 754
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 829-1066 5.45e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 41.13  E-value: 5.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  829 HARGARALREAEQEPELEARVAVLATQLG--MLEDAEQLYRKCKRHDLLNKFYQAAGRWQEALQVAEHHDRV--HLRSTY 904
Cdd:COG3914    36 ALAAALGLALLLLAALAEAAAAALLALAAgeAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALnpDNAEAL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  905 HRYAGHLEASADCSRALSYYEKSdthrfevprmLSEDLPSLELYVNkmkdktlwrwWAQYLESQGEMDAALHYYE--LAR 982
Cdd:COG3914   116 FNLGNLLLALGRLEEALAALRRA----------LALNPDFAEAYLN----------LGEALRRLGRLEEAIAALRraLEL 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  983 D------HFSLVRIHCFQGNVQKAAQIANET-----GNLAASYHLARQYESQEEvgqavhfYTRAQAFKNAIRLCKENGl 1051
Cdd:COG3914   176 DpdnaeaLNNLGNALQDLGRLEEAIAAYRRAleldpDNADAHSNLLFALRQACD-------WEVYDRFEELLAALARGP- 247

                         250
                  ....*....|....*
gi 578828380 1052 dDQLMNLALLSSPED 1066
Cdd:COG3914   248 -SELSPFALLYLPDD 261
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 102-130 6.29e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.75  E-value: 6.29e-03
                            10        20
                    ....*....|....*....|....*....
gi 578828380    102 HTADITVLRWSPSGNCLLSGDRLGVLLLW 130
Cdd:smart00320   11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
803-1043 7.69e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.99  E-value: 7.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  803 VWENMARMCVKTQRLDVAKVCLgnmghargARALREAEQEPELEARVAVLATQLGMLEDAEQLYRKCKRHD------LLN 876
Cdd:COG0457    10 AYNNLGLAYRRLGRYEEAIEDY--------EKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDpddaeaLNN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  877 K--FYQAAGRWQEALqvaEHHDRV-----HLRSTYHRYAGHLEASADCSRALSYYEKsdthrfevprmlsedlpSLELyv 949
Cdd:COG0457    82 LglALQALGRYEEAL---EDYDKAleldpDDAEALYNLGLALLELGRYDEAIEAYER-----------------ALEL-- 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578828380  950 nKMKDKTLWRWWAQYLESQGEMDAALHYYELARDHFSLVRIHCFQGNVQKAAQIANETGNLAASYHLARQYESQEEVGQA 1029
Cdd:COG0457   140 -DPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAA 218

                         250
                  ....*....|....
gi 578828380 1030 VHFYTRAQAFKNAI 1043
Cdd:COG0457   219 LAELLLLALALLLA 232
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 63-112 7.70e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 37.26  E-value: 7.70e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 578828380    63 RVASLCWHPTRLVLAVGWETGEVTVFNKQD-KEQHTMPlTHTADITVLRWS 112
Cdd:pfam12894   40 EVTSLAWRPDGKLLAVGYSDGTVRLLDAENgKIVHHFS-AGSDLITCLGWG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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