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Conserved domains on  [gi|578821198|ref|XP_006718525|]
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von Willebrand factor C and EGF domain-containing protein isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 666-884 1.05e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198  666 RACADPALLPGDccSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAP--------VNCSSCPGPPTASPSRPVLH 737
Cdd:PHA03247 2609 RGPAPPSPLPPD--THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprrARRLGRAAQASSPPQRPRRR 2686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198  738 LLQLL--LRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTP--------PGAPTLPLASPGAPQP 807
Cdd:PHA03247 2687 AARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPavpagpatPGGPARPARPPTTAGP 2766

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578821198  808 PPVTPERSfSASGAQivSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 884
Cdd:PHA03247 2767 PAPAPPAA-PAAGPP--RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 501-559 9.65e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 43.57  E-value: 9.65e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578821198  501 CYFHGRWYADGAVFSGggDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTC 559
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNPRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
572-624 1.89e-04

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.19  E-value: 1.89e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 578821198   572 DNGVEFPIGQIWSPgDPCELCICQLGS-VACSPVDCP--ITCTYPFH--PDGECCPVC 624
Cdd:smart00214   3 HNGRVYNDGETWKP-DPCQICTCLDGTtVLCDPVECPppPDCPNPERvkPPGECCPRC 59
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 386-440 2.20e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 39.72  E-value: 2.20e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 578821198  386 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAA-CSHPIPS-RDGGCCPSC 440
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLdCPNPRLEiPPGECCPVC 57
EGF_CA smart00179
Calcium-binding EGF-like domain;
220-262 5.24e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 5.24e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 578821198   220 DVNECrrpLERRVCHH--SCHNTVGSFLCTCRPGFRlraDRVSCE 262
Cdd:smart00179   1 DIDEC---ASGNPCQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-180 7.10e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 7.10e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 578821198   142 DIDECVTS---SCEGHCVNTEGGFVCECGPGMQlsaDRHSCQ 180
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 190-218 8.37e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.61  E-value: 8.37e-04
                          10        20
                  ....*....|....*....|....*....
gi 578821198  190 CQQRCKNSIGSYKCSCRTGFHLHGNRHSC 218
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 627-682 1.54e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 37.40  E-value: 1.54e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578821198  627 CNYEGRKVANGQVFTLDdePCTRCTCQLGEVSCEKVPCQRA-CADPAL--LPGDCCSSC 682
Cdd:pfam00093   1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLdCPNPRLeiPPGECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 443-488 4.34e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 36.25  E-value: 4.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 578821198  443 CFHSGVVRAEGDVFSPpnENCTVCVCLAGNVSCISPECPSGPCQTP 488
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNP 44
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 666-884 1.05e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198  666 RACADPALLPGDccSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAP--------VNCSSCPGPPTASPSRPVLH 737
Cdd:PHA03247 2609 RGPAPPSPLPPD--THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprrARRLGRAAQASSPPQRPRRR 2686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198  738 LLQLL--LRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTP--------PGAPTLPLASPGAPQP 807
Cdd:PHA03247 2687 AARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPavpagpatPGGPARPARPPTTAGP 2766

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578821198  808 PPVTPERSfSASGAQivSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 884
Cdd:PHA03247 2767 PAPAPPAA-PAAGPP--RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 501-559 9.65e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 43.57  E-value: 9.65e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578821198  501 CYFHGRWYADGAVFSGggDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTC 559
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNPRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
501-559 1.55e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.58  E-value: 1.55e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578821198   501 CYFHGRWYADGAVFSGggDECTTCVCQNGE-VECSFMPCPE-LACPREEWRLGPGQCCFTC 559
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
572-624 1.89e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.19  E-value: 1.89e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 578821198   572 DNGVEFPIGQIWSPgDPCELCICQLGS-VACSPVDCP--ITCTYPFH--PDGECCPVC 624
Cdd:smart00214   3 HNGRVYNDGETWKP-DPCQICTCLDGTtVLCDPVECPppPDCPNPERvkPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 386-440 2.20e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.72  E-value: 2.20e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 578821198  386 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAA-CSHPIPS-RDGGCCPSC 440
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLdCPNPRLEiPPGECCPVC 57
EGF_CA smart00179
Calcium-binding EGF-like domain;
220-262 5.24e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 5.24e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 578821198   220 DVNECrrpLERRVCHH--SCHNTVGSFLCTCRPGFRlraDRVSCE 262
Cdd:smart00179   1 DIDEC---ASGNPCQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-180 7.10e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 7.10e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 578821198   142 DIDECVTS---SCEGHCVNTEGGFVCECGPGMQlsaDRHSCQ 180
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 573-624 7.30e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 38.56  E-value: 7.30e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 578821198  573 NGVEFPIGQIWSPgDPCELCICQLGSVACSPVDCPI-TCTYPFH--PDGECCPVC 624
Cdd:pfam00093   4 NGVVYENGETWKP-DLCTICTCDDGKVLCDKIICPPlDCPNPRLeiPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
386-440 7.35e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 38.65  E-value: 7.35e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 578821198   386 CWHLGAMHESRSRWTEPGCSQCWCEDGK-VTCEKVRCEAA--CSHPIPSRDGG-CCPSC 440
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPPpdCPNPERVKPPGeCCPRC 59
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 190-218 8.37e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.61  E-value: 8.37e-04
                          10        20
                  ....*....|....*....|....*....
gi 578821198  190 CQQRCKNSIGSYKCSCRTGFHLHGNRHSC 218
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 220-255 1.10e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.10e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 578821198 220 DVNECrrpLERRVC--HHSCHNTVGSFLCTCRPGFRLR 255
Cdd:cd00054    1 DIDEC---ASGNPCqnGGTCVNTVGSYRCSCPPGYTGR 35
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 627-682 1.54e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.40  E-value: 1.54e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578821198  627 CNYEGRKVANGQVFTLDdePCTRCTCQLGEVSCEKVPCQRA-CADPAL--LPGDCCSSC 682
Cdd:pfam00093   1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLdCPNPRLeiPPGECCPVC 57
EGF_CA pfam07645
Calcium-binding EGF domain;
220-251 2.10e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 2.10e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 578821198  220 DVNECRRPleRRVCHHS--CHNTVGSFLCTCRPG 251
Cdd:pfam07645   1 DVDECATG--THNCPANtvCVNTIGSFECRCPDG 32
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 749-883 2.28e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 2.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198  749 KTQTLPTSPAGAHGPHSLAlglTATFPGEPGASPRLSPGPstPPGAPTL-PLASPGAPQPP----PVTPERSFSASGAQI 823
Cdd:pfam03154 163 QQQILQTQPPVLQAQSGAA---SPPSPPPPGTTQAATAGP--TPSAPSVpPQGSPATSQPPnqtqSTAAPHTLIQQTPTL 237

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578821198  824 VSRWPPLPGTLLTEASAlsmmDPSPSKTPITLLGPRVL----SPTTSRLSTALAATTHPGPQQP 883
Cdd:pfam03154 238 HPQRLPSPHPPLQPMTQ----PPPPSQVSPQPLPQPSLhgqmPPMPHSLQTGPSHMQHPVPPQP 297
EGF_CA smart00179
Calcium-binding EGF-like domain;
181-214 3.11e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 3.11e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 578821198   181 DTDECL-GTPCQQ--RCKNSIGSYKCSCRTGFHLHGN 214
Cdd:smart00179   1 DIDECAsGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 181-212 3.69e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 3.69e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 578821198 181 DTDECL-GTPCQ--QRCKNSIGSYKCSCRTGFHLH 212
Cdd:cd00054    1 DIDECAsGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 443-488 4.34e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 36.25  E-value: 4.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 578821198  443 CFHSGVVRAEGDVFSPpnENCTVCVCLAGNVSCISPECPSGPCQTP 488
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNP 44
VWC smart00214
von Willebrand factor (vWF) type C domain;
627-682 8.54e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 35.57  E-value: 8.54e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578821198   627 CNYEGRKVANGQVFTldDEPCTRCTCQLGE-VSCEKVPCQRA--CADP--ALLPGDCCSSC 682
Cdd:smart00214   1 CVHNGRVYNDGETWK--PDPCQICTCLDGTtVLCDPVECPPPpdCPNPerVKPPGECCPRC 59
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 142-172 8.70e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 8.70e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 578821198 142 DIDECVTSS---CEGHCVNTEGGFVCECGPGMQL 172
Cdd:cd00054    1 DIDECASGNpcqNGGTCVNTVGSYRCSCPPGYTG 34
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 666-884 1.05e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198  666 RACADPALLPGDccSSCPDSLSPLEEKQGLSPHGNVAFSKAGRSLHGDTEAP--------VNCSSCPGPPTASPSRPVLH 737
Cdd:PHA03247 2609 RGPAPPSPLPPD--THAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPgrvsrprrARRLGRAAQASSPPQRPRRR 2686

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198  738 LLQLL--LRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTP--------PGAPTLPLASPGAPQP 807
Cdd:PHA03247 2687 AARPTvgSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPavpagpatPGGPARPARPPTTAGP 2766

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 578821198  808 PPVTPERSfSASGAQivSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 884
Cdd:PHA03247 2767 PAPAPPAA-PAAGPP--RRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 501-559 9.65e-06

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 43.57  E-value: 9.65e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578821198  501 CYFHGRWYADGAVFSGggDECTTCVCQNGEVECSFMPCPELACPREEWRLGPGQCCFTC 559
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNPRLEIPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
501-559 1.55e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.58  E-value: 1.55e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578821198   501 CYFHGRWYADGAVFSGggDECTTCVCQNGE-VECSFMPCPE-LACPREEWRLGPGQCCFTC 559
Cdd:smart00214   1 CVHNGRVYNDGETWKP--DPCQICTCLDGTtVLCDPVECPPpPDCPNPERVKPPGECCPRC 59
VWC smart00214
von Willebrand factor (vWF) type C domain;
572-624 1.89e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 40.19  E-value: 1.89e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 578821198   572 DNGVEFPIGQIWSPgDPCELCICQLGS-VACSPVDCP--ITCTYPFH--PDGECCPVC 624
Cdd:smart00214   3 HNGRVYNDGETWKP-DPCQICTCLDGTtVLCDPVECPppPDCPNPERvkPPGECCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 386-440 2.20e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 39.72  E-value: 2.20e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 578821198  386 CWHLGAMHESRSRWTEPGCSQCWCEDGKVTCEKVRCEAA-CSHPIPS-RDGGCCPSC 440
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLCDKIICPPLdCPNPRLEiPPGECCPVC 57
PHA03247 PHA03247
large tegument protein UL36; Provisional
 714-884 2.97e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 2.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198  714 TEAPVNCSSCPGPPTASPSR-PVLHLLQLLLRTNLMKTQTLPTSPAGAHGPHSLALGLTATfPGEPGASP----RLSPGP 788
Cdd:PHA03247 2763 TAGPPAPAPPAAPAAGPPRRlTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAAS-PAGPLPPPtsaqPTAPPP 2841

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198  789 STPPGAPTLPLA---SPGAP---QPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLS 862
Cdd:PHA03247 2842 PPGPPPPSLPLGgsvAPGGDvrrRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQP 2921

                         170       180
                  ....*....|....*....|..
gi 578821198  863 PTTSRLSTALAATTHPGPQQPP 884
Cdd:PHA03247 2922 QPPPPPQPQPPPPPPPRPQPPL 2943
motB PRK12799
flagellar motor protein MotB; Reviewed
 745-889 3.98e-04

flagellar motor protein MotB; Reviewed


Pssm-ID: 183756 [Multi-domain]  Cd Length: 421  Bit Score: 43.94  E-value: 3.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198 745 TNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGasprlSPGPSTPPGAPTLPLASPgapqpppvTPERSFSASGAQIV 824
Cdd:PRK12799 288 TGLKQIDTHGTVPVAAVTPSSAVTQSSAITPSSAA-----IPSPAVIPSSVTTQSATT--------TQASAVALSSAGVL 354

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578821198 825 SRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPR-VLSPTTSRLSTALAATthPGPQQPPVGASR 889
Cdd:PRK12799 355 PSDVTLPGTVALPAAEPVNMQPQPMSTTETQQSSTgNITSTANGPTTSLPAA--PASNIPVSPTSR 418
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
702-884 4.71e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 4.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198 702 AFSKAGRSlhGDTeAPVNCSSCP---GPPTASPSRPVLHLLQLLLRTNLMKTQTLPTSPAGAHGPHSLALGLTATFPG-- 776
Cdd:PRK12323 362 AFRPGQSG--GGA-GPATAAAAPvaqPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAArq 438

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198 777 ----------EPGASPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLltEASALSMMDP 846
Cdd:PRK12323 439 asargpggapAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEF--ASPAPAQPDA 516

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 578821198 847 SPS---KTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 884
Cdd:PRK12323 517 APAgwvAESIPDPATADPDDAFETLAPAPAAAPAPRAAAAT 557
EGF_CA smart00179
Calcium-binding EGF-like domain;
220-262 5.24e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 5.24e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 578821198   220 DVNECrrpLERRVCHH--SCHNTVGSFLCTCRPGFRlraDRVSCE 262
Cdd:smart00179   1 DIDEC---ASGNPCQNggTCVNTVGSYRCECPPGYT---DGRNCE 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
 724-884 5.83e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 5.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198  724 PGPPTASPSRPVLHLLQLLLRTNlmktqtlPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASPG 803
Cdd:PHA03247 2557 PAAPPAAPDRSVPPPRPAPRPSE-------PAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPP 2629

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198  804 APQPPPVT-PERSFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLsTALAATTHPGPQQ 882
Cdd:PHA03247 2630 SPSPAANEpDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSL-TSLADPPPPPPTP 2708


                  ..
gi 578821198  883 PP 884
Cdd:PHA03247 2709 EP 2710
PHA03378 PHA03378
EBNA-3B; Provisional
 744-884 6.65e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.52  E-value: 6.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198 744 RTNLMKTQTLPTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQI 823
Cdd:PHA03378 663 KPTWTQIGHIPYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPG 742

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 578821198 824 VSRWPP-LPGTLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPP 884
Cdd:PHA03378 743 RARPPAaAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGP 804
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-180 7.10e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 7.10e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 578821198   142 DIDECVTS---SCEGHCVNTEGGFVCECGPGMQlsaDRHSCQ 180
Cdd:smart00179   1 DIDECASGnpcQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 573-624 7.30e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 38.56  E-value: 7.30e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 578821198  573 NGVEFPIGQIWSPgDPCELCICQLGSVACSPVDCPI-TCTYPFH--PDGECCPVC 624
Cdd:pfam00093   4 NGVVYENGETWKP-DLCTICTCDDGKVLCDKIICPPlDCPNPRLeiPPGECCPVC 57
VWC smart00214
von Willebrand factor (vWF) type C domain;
386-440 7.35e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 38.65  E-value: 7.35e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 578821198   386 CWHLGAMHESRSRWTEPGCSQCWCEDGK-VTCEKVRCEAA--CSHPIPSRDGG-CCPSC 440
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTtVLCDPVECPPPpdCPNPERVKPPGeCCPRC 59
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 190-218 8.37e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 37.61  E-value: 8.37e-04
                          10        20
                  ....*....|....*....|....*....
gi 578821198  190 CQQRCKNSIGSYKCSCRTGFHLHGNRHSC 218
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 220-255 1.10e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 1.10e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 578821198 220 DVNECrrpLERRVC--HHSCHNTVGSFLCTCRPGFRLR 255
Cdd:cd00054    1 DIDEC---ASGNPCqnGGTCVNTVGSYRCSCPPGYTGR 35
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 723-895 1.15e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 42.85  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198  723 CPGPPTASPSRPVLHLLQLLLRTnlmktqTLPTSPAGAHGPHSlalGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASP 802
Cdd:PHA03307   72 PPGPGTEAPANESRSTPTWSLST------LAPASPAREGSPTP---PGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVG 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198  803 G---APQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMmdPSPSKTPITLLGPRVLSPTTSRL-STALAATTHP 878
Cdd:PHA03307  143 SpgpPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAP--SSPPAEPPPSTPPAAASPRPPRRsSPISASASSP 220

                         170
                  ....*....|....*..
gi 578821198  879 GPQQPPVGASRGEESTM 895
Cdd:PHA03307  221 APAPGRSAADDAGASSS 237
PHA03378 PHA03378
EBNA-3B; Provisional
 726-889 1.46e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.36  E-value: 1.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198 726 PPTASPSRPVLHLLQLLLRTNLMktQTLPTSPAGAHGPH------SLALGLTATFPGEPGASPRlSPGPST------PPG 793
Cdd:PHA03378 616 PETSAPRQWPMPLRPIPMRPLRM--QPITFNVLVFPTPHqppqveITPYKPTWTQIGHIPYQPS-PTGANTmlpiqwAPG 692

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198 794 APTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTPiTLLGPRVLSPTTSRLSTAL- 872
Cdd:PHA03378 693 TMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAP-GRARPPAAAPGRARPPAAAp 771

                        170
                 ....*....|....*...
gi 578821198 873 -AATTHPGPQQPPVGASR 889
Cdd:PHA03378 772 gAPTPQPPPQAPPAPQQR 789
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 627-682 1.54e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.40  E-value: 1.54e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 578821198  627 CNYEGRKVANGQVFTLDdePCTRCTCQLGEVSCEKVPCQRA-CADPAL--LPGDCCSSC 682
Cdd:pfam00093   1 CVQNGVVYENGETWKPD--LCTICTCDDGKVLCDKIICPPLdCPNPRLeiPPGECCPVC 57
EGF_CA pfam07645
Calcium-binding EGF domain;
220-251 2.10e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 2.10e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 578821198  220 DVNECRRPleRRVCHHS--CHNTVGSFLCTCRPG 251
Cdd:pfam07645   1 DVDECATG--THNCPANtvCVNTIGSFECRCPDG 32
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
754-894 2.13e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.79  E-value: 2.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198 754 PTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAPTLPLASPGAPQPPPVTPERSFSASGAQIVSRWPPLPGT 833
Cdd:PRK12323 365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP 444

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578821198 834 LLTEASAlsmmdPSPSKTPItllgPRVLSPTTSRLSTALAATTHPGPQQPPVGASRGEEST 894
Cdd:PRK12323 445 GGAPAPA-----PAPAAAPA----AAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDP 496
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 749-883 2.28e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 2.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198  749 KTQTLPTSPAGAHGPHSLAlglTATFPGEPGASPRLSPGPstPPGAPTL-PLASPGAPQPP----PVTPERSFSASGAQI 823
Cdd:pfam03154 163 QQQILQTQPPVLQAQSGAA---SPPSPPPPGTTQAATAGP--TPSAPSVpPQGSPATSQPPnqtqSTAAPHTLIQQTPTL 237

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 578821198  824 VSRWPPLPGTLLTEASAlsmmDPSPSKTPITLLGPRVL----SPTTSRLSTALAATTHPGPQQP 883
Cdd:pfam03154 238 HPQRLPSPHPPLQPMTQ----PPPPSQVSPQPLPQPSLhgqmPPMPHSLQTGPSHMQHPVPPQP 297
EGF_CA smart00179
Calcium-binding EGF-like domain;
181-214 3.11e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 3.11e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 578821198   181 DTDECL-GTPCQQ--RCKNSIGSYKCSCRTGFHLHGN 214
Cdd:smart00179   1 DIDECAsGNPCQNggTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 181-212 3.69e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 3.69e-03
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 578821198 181 DTDECL-GTPCQ--QRCKNSIGSYKCSCRTGFHLH 212
Cdd:cd00054    1 DIDECAsGNPCQngGTCVNTVGSYRCSCPPGYTGR 35
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 784-884 3.83e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.95  E-value: 3.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198 784 LSPGPSTPPGAPTLPLASPGAPQPPPVTPersFSASGAQIVSRWPPLPGTLLTEASALSMMDPSPSKTpitllgPRVLSP 863
Cdd:PRK14950 360 LVPVPAPQPAKPTAAAPSPVRPTPAPSTR---PKAAAAANIPPKEPVRETATPPPVPPRPVAPPVPHT------PESAPK 430

                         90       100
                 ....*....|....*....|.
gi 578821198 864 TTSRLSTALAATTHPGPQQPP 884
Cdd:PRK14950 431 LTRAAIPVDEKPKYTPPAPPK 451
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 443-488 4.34e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 36.25  E-value: 4.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 578821198  443 CFHSGVVRAEGDVFSPpnENCTVCVCLAGNVSCISPECPSGPCQTP 488
Cdd:pfam00093   1 CVQNGVVYENGETWKP--DLCTICTCDDGKVLCDKIICPPLDCPNP 44
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 233-261 4.88e-03

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 35.30  E-value: 4.88e-03
                          10        20
                  ....*....|....*....|....*....
gi 578821198  233 CHHSCHNTVGSFLCTCRPGFRLRADRVSC 261
Cdd:pfam14670   8 CSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
PHA03379 PHA03379
EBNA-3A; Provisional
 689-885 5.77e-03

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 40.43  E-value: 5.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198 689 LEEKQGLSPHGNVAFSKAGRSLHGDteapvncsscPGPPTASPSRPVLHLLQLLLRTNLMKTQTLPTSPAGAHGP----H 764
Cdd:PHA03379 391 LMRAGKLTERAREALEKASEPTYGT----------PRPPVEKPRPEVPQSLETATSHGSAQVPEPPPVHDLEPGPlhdqH 460

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198 765 SLALGLTATFPgePGASPRLSPGpSTPPGAPTLPLASPgAPQPPPVTP-ERSFSASGAQIVSRWP------PLPGTLLTE 837
Cdd:PHA03379 461 SMAPCPVAQLP--PGPLQDLEPG-DQLPGVVQDGRPAC-APVPAPAGPiVRPWEASLSQVPGVAFapvmpqPMPVEPVPV 536

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 578821198 838 ASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTALAATTHPGPQQPPV 885
Cdd:PHA03379 537 PTVALERPVCPAPPLIAMQGPGETSGIVRVRERWRPAPWTPNPPRSPS 584
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 202-223 6.92e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 34.69  E-value: 6.92e-03
                          10        20
                  ....*....|....*....|..
gi 578821198  202 KCSCRTGFHLHGNRHSCVDVNE 223
Cdd:pfam12662   1 TCSCPPGYQLDPDGRTCVDIDE 22
VWC smart00214
von Willebrand factor (vWF) type C domain;
627-682 8.54e-03

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 35.57  E-value: 8.54e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578821198   627 CNYEGRKVANGQVFTldDEPCTRCTCQLGE-VSCEKVPCQRA--CADP--ALLPGDCCSSC 682
Cdd:smart00214   1 CVHNGRVYNDGETWK--PDPCQICTCLDGTtVLCDPVECPPPpdCPNPerVKPPGECCPRC 59
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 142-172 8.70e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 34.92  E-value: 8.70e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 578821198 142 DIDECVTSS---CEGHCVNTEGGFVCECGPGMQL 172
Cdd:cd00054    1 DIDECASGNpcqNGGTCVNTVGSYRCSCPPGYTG 34
Amnionless pfam14828
Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for ...
 589-647 9.09e-03

Amnionless; The amnionless protein forms a complex with cubilin. This complex is necessary for vitamin B12 uptake.


Pssm-ID: 464340  Cd Length: 449  Bit Score: 39.68  E-value: 9.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 578821198  589 CELCICQ---LGSVACSPVD--CPI-TCTYPFHPDGECCPVCrdcnyegrkvanGQVFTLDDEPC 647
Cdd:pfam14828 194 PSGCGCGndeNLERICANVLqrCPPpHCLSPLRPEGHCCDVC------------GAIVSLDYSSC 246
PHA03247 PHA03247
large tegument protein UL36; Provisional
 724-885 9.30e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 9.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198  724 PGPPTASPSRPVLHLLQLLLRTNLMKTQTL--------PTSPAGAHGPHSLALGLTATFPGEPGASPRLSPGPSTPPGAP 795
Cdd:PHA03247 2710 PAPHALVSATPLPPGPAAARQASPALPAAPappavpagPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVA 2789

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578821198  796 TLPLASPGAPQPP-PVTPERSFSASGAQIVSRWPPLPG--TLLTEASALSMMDPSPSKTPITLLGPRVLSPTTSRLSTAL 872
Cdd:PHA03247 2790 SLSESRESLPSPWdPADPPAAVLAPAAALPPAASPAGPlpPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSR 2869

                         170
                  ....*....|....
gi 578821198  873 AATTHPG-PQQPPV 885
Cdd:PHA03247 2870 SPAAKPAaPARPPV 2883
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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