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Conserved domains on  [gi|578817525|ref|XP_006717192|]
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pappalysin-1 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
myxo_disulf_rpt TIGR02232
Myxococcus cysteine-rich repeat; This model represents a sequence region shared between ...
 246-285 1.77e-13

Myxococcus cysteine-rich repeat; This model represents a sequence region shared between several proteins of Myxococcus xanthus DK 1622 and some eukaryotic proteins that include human pappalysin-1 (SP|Q13219). The region of about 40 amino acids contains several conserved Cys residues presumed to form disulfide bonds. The region appears in up to 13 repeats in Myxococcus.


:

Pssm-ID: 200169 [Multi-domain]  Cd Length: 38  Bit Score: 65.09  E-value: 1.77e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 578817525  246 SGYCGDGIIQKdqGEQCDDMNKINGDGCSLFCRQEVSFNC 285
Cdd:TIGR02232   1 APTCGDGIIEP--GEECDDGNTTSGDGCSATCRLEEGFAC 38
Sushi pfam00084
Sushi repeat (SCR repeat);
717-773 2.80e-10

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 56.74  E-value: 2.80e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 578817525  717 CDPPPPKFHGLYQCT-NGFQFNSECRIKCEDSDASQGlgSNVIHCRKDGTWNGSFHVC 773
Cdd:pfam00084   1 CPPPPDIPNGKVSATkNEYNYGASVSYECDPGYRLVG--SPTITCQEDGTWSPPFPEC 56
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 849-885 1.64e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


:

Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.09  E-value: 1.64e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 578817525   849 PHPALIHC-VKGCEPFMGDNYCDAINNRAFCNYDGGDC 885
Cdd:smart00004   1 PQDPWSRCeDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
Sushi pfam00084
Sushi repeat (SCR repeat);
648-707 3.54e-06

Sushi repeat (SCR repeat);


:

Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 44.80  E-value: 3.54e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817525  648 CLAPPPVPNADLQtarCRENKHKVGSFCKYKCKPGYHVPGSSrkskkrafKTQCTQDGSW 707
Cdd:pfam00084   1 CPPPPDIPNGKVS---ATKNEYNYGASVSYECDPGYRLVGSP--------TITCQEDGTW 49
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 598-645 8.64e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 38.21  E-value: 8.64e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 578817525 598 ASFSCPEGT-TFGSQCSFQCRHPAQLKGNNSLlTCMEDGLWSFPEALCE 645
Cdd:cd00033   10 GTVTGSKGSySYGSTVTYSCNEGYTLVGSSTI-TCTENGGWSPPPPTCE 57
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 517-577 3.17e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 36.67  E-value: 3.17e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578817525 517 CPEL-AVENASLNCSSSDRYHGAQCTVSCRTGYVLQirrddeliksqtgPSVTVTCTE-GKWN 577
Cdd:cd00033    1 CPPPpVPENGTVTGSKGSYSYGSTVTYSCNEGYTLV-------------GSSTITCTEnGGWS 50
 
Name Accession Description Interval E-value
myxo_disulf_rpt TIGR02232
Myxococcus cysteine-rich repeat; This model represents a sequence region shared between ...
 246-285 1.77e-13

Myxococcus cysteine-rich repeat; This model represents a sequence region shared between several proteins of Myxococcus xanthus DK 1622 and some eukaryotic proteins that include human pappalysin-1 (SP|Q13219). The region of about 40 amino acids contains several conserved Cys residues presumed to form disulfide bonds. The region appears in up to 13 repeats in Myxococcus.


Pssm-ID: 200169 [Multi-domain]  Cd Length: 38  Bit Score: 65.09  E-value: 1.77e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 578817525  246 SGYCGDGIIQKdqGEQCDDMNKINGDGCSLFCRQEVSFNC 285
Cdd:TIGR02232   1 APTCGDGIIEP--GEECDDGNTTSGDGCSATCRLEEGFAC 38
Sushi pfam00084
Sushi repeat (SCR repeat);
717-773 2.80e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 56.74  E-value: 2.80e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 578817525  717 CDPPPPKFHGLYQCT-NGFQFNSECRIKCEDSDASQGlgSNVIHCRKDGTWNGSFHVC 773
Cdd:pfam00084   1 CPPPPDIPNGKVSATkNEYNYGASVSYECDPGYRLVG--SPTITCQEDGTWSPPFPEC 56
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 849-885 1.64e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.09  E-value: 1.64e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 578817525   849 PHPALIHC-VKGCEPFMGDNYCDAINNRAFCNYDGGDC 885
Cdd:smart00004   1 PQDPWSRCeDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
Sushi pfam00084
Sushi repeat (SCR repeat);
648-707 3.54e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 44.80  E-value: 3.54e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817525  648 CLAPPPVPNADLQtarCRENKHKVGSFCKYKCKPGYHVPGSSrkskkrafKTQCTQDGSW 707
Cdd:pfam00084   1 CPPPPDIPNGKVS---ATKNEYNYGASVSYECDPGYRLVGSP--------TITCQEDGTW 49
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 648-723 3.84e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 44.76  E-value: 3.84e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578817525 648 CLAPPPVPNADLqtaRCRENKHKVGSFCKYKCKPGYHVPGSSRkskkrafkTQCTQDGSWqegacvpvtcDPPPPK 723
Cdd:cd00033    1 CPPPPVPENGTV---TGSKGSYSYGSTVTYSCNEGYTLVGSST--------ITCTENGGW----------SPPPPT 55
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 717-774 2.46e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 42.45  E-value: 2.46e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 578817525 717 CDPPPPKFHGLYQCTNG-FQFNSECRIKCEDSDASQGlgSNVIHCRKDGTWNGSFHVCQ 774
Cdd:cd00033    1 CPPPPVPENGTVTGSKGsYSYGSTVTYSCNEGYTLVG--SSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 648-707 2.76e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 42.51  E-value: 2.76e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817525   648 CLAPPPVPNAdlqTARCRENKHKVGSFCKYKCKPGYHVPGSSRkskkrafkTQCTQDGSW 707
Cdd:smart00032   1 CPPPPDIENG---TVTSSSGTYSYGDTVTYSCDPGYTLIGSST--------ITCLENGTW 49
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 717-773 3.85e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 39.43  E-value: 3.85e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 578817525   717 CDPPPPKFHGLYQCTNG-FQFNSECRIKCEDSdaSQGLGSNVIHCRKDGTWNGSFHVC 773
Cdd:smart00032   1 CPPPPDIENGTVTSSSGtYSYGDTVTYSCDPG--YTLIGSSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 598-645 8.64e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 38.21  E-value: 8.64e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 578817525 598 ASFSCPEGT-TFGSQCSFQCRHPAQLKGNNSLlTCMEDGLWSFPEALCE 645
Cdd:cd00033   10 GTVTGSKGSySYGSTVTYSCNEGYTLVGSSTI-TCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 587-644 1.84e-03

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 37.51  E-value: 1.84e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 578817525   587 CSIPDhhQVYAASFSCPEGT-TFGSQCSFQCRHPAQLKGNNSLlTCMEDGLWSFPEALC 644
Cdd:smart00032   1 CPPPP--DIENGTVTSSSGTySYGDTVTYSCDPGYTLIGSSTI-TCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 517-577 3.17e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 36.67  E-value: 3.17e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578817525 517 CPEL-AVENASLNCSSSDRYHGAQCTVSCRTGYVLQirrddeliksqtgPSVTVTCTE-GKWN 577
Cdd:cd00033    1 CPPPpVPENGTVTGSKGSYSYGSTVTYSCNEGYTLV-------------GSSTITCTEnGGWS 50
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 644-853 4.27e-03

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 40.02  E-value: 4.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817525 644 CELMCLAPPPVP-NADLQTA--RCRENKHKVGSFCKYKCKPGYhvpgssRKSKKRAFKTQCTQDGSWQEGACVPVTCDPP 720
Cdd:PHA02927  16 CVLSCCTIPSRPiNMKFKNSveTDANANYNIGDTIEYLCLPGY------RKQKMGPIYAKCTGTGWTLFNQCIKRRCPSP 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817525 721 PPKFHG-------------LYQCTNGFQFNSECRIKCEdsdasqgLGSNvihcrKDGTWNGSFHVCQEMqgQCSVPNELN 787
Cdd:PHA02927  90 RDIDNGqldiggvdfgssiTYSCNSGYQLIGESKSYCE-------LGST-----GSMVWNPEAPICESV--KCQSPPSIS 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578817525 788 SNLKLQCPDGYAIGSECATSCldhNSESIILPMNVTVRDIPHWLNPTRVERVVCtaglkwyPHPAL 853
Cdd:PHA02927 156 NGRHNGYEDFYTDGSVVTYSC---NSGYSLIGNSGVLCSGGEWSDPPTCQIVKC-------PHPTI 211
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 517-577 9.66e-03

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 35.19  E-value: 9.66e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578817525   517 CPEL-AVENASLNCSSSDRYHGAQCTVSCRTGYVLQirrddeliksqtgPSVTVTCTE-GKWN 577
Cdd:smart00032   1 CPPPpDIENGTVTSSSGTYSYGDTVTYSCDPGYTLI-------------GSSTITCLEnGTWS 50
 
Name Accession Description Interval E-value
myxo_disulf_rpt TIGR02232
Myxococcus cysteine-rich repeat; This model represents a sequence region shared between ...
 246-285 1.77e-13

Myxococcus cysteine-rich repeat; This model represents a sequence region shared between several proteins of Myxococcus xanthus DK 1622 and some eukaryotic proteins that include human pappalysin-1 (SP|Q13219). The region of about 40 amino acids contains several conserved Cys residues presumed to form disulfide bonds. The region appears in up to 13 repeats in Myxococcus.


Pssm-ID: 200169 [Multi-domain]  Cd Length: 38  Bit Score: 65.09  E-value: 1.77e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 578817525  246 SGYCGDGIIQKdqGEQCDDMNKINGDGCSLFCRQEVSFNC 285
Cdd:TIGR02232   1 APTCGDGIIEP--GEECDDGNTTSGDGCSATCRLEEGFAC 38
Sushi pfam00084
Sushi repeat (SCR repeat);
717-773 2.80e-10

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 56.74  E-value: 2.80e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 578817525  717 CDPPPPKFHGLYQCT-NGFQFNSECRIKCEDSDASQGlgSNVIHCRKDGTWNGSFHVC 773
Cdd:pfam00084   1 CPPPPDIPNGKVSATkNEYNYGASVSYECDPGYRLVG--SPTITCQEDGTWSPPFPEC 56
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 849-885 1.64e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.09  E-value: 1.64e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 578817525   849 PHPALIHC-VKGCEPFMGDNYCDAINNRAFCNYDGGDC 885
Cdd:smart00004   1 PQDPWSRCeDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
Sushi pfam00084
Sushi repeat (SCR repeat);
648-707 3.54e-06

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 44.80  E-value: 3.54e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817525  648 CLAPPPVPNADLQtarCRENKHKVGSFCKYKCKPGYHVPGSSrkskkrafKTQCTQDGSW 707
Cdd:pfam00084   1 CPPPPDIPNGKVS---ATKNEYNYGASVSYECDPGYRLVGSP--------TITCQEDGTW 49
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 648-723 3.84e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 44.76  E-value: 3.84e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578817525 648 CLAPPPVPNADLqtaRCRENKHKVGSFCKYKCKPGYHVPGSSRkskkrafkTQCTQDGSWqegacvpvtcDPPPPK 723
Cdd:cd00033    1 CPPPPVPENGTV---TGSKGSYSYGSTVTYSCNEGYTLVGSST--------ITCTENGGW----------SPPPPT 55
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 717-774 2.46e-05

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 42.45  E-value: 2.46e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 578817525 717 CDPPPPKFHGLYQCTNG-FQFNSECRIKCEDSDASQGlgSNVIHCRKDGTWNGSFHVCQ 774
Cdd:cd00033    1 CPPPPVPENGTVTGSKGsYSYGSTVTYSCNEGYTLVG--SSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 648-707 2.76e-05

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 42.51  E-value: 2.76e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817525   648 CLAPPPVPNAdlqTARCRENKHKVGSFCKYKCKPGYHVPGSSRkskkrafkTQCTQDGSW 707
Cdd:smart00032   1 CPPPPDIENG---TVTSSSGTYSYGDTVTYSCDPGYTLIGSST--------ITCLENGTW 49
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 717-773 3.85e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 39.43  E-value: 3.85e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 578817525   717 CDPPPPKFHGLYQCTNG-FQFNSECRIKCEDSdaSQGLGSNVIHCRKDGTWNGSFHVC 773
Cdd:smart00032   1 CPPPPDIENGTVTSSSGtYSYGDTVTYSCDPG--YTLIGSSTITCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 598-645 8.64e-04

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 38.21  E-value: 8.64e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 578817525 598 ASFSCPEGT-TFGSQCSFQCRHPAQLKGNNSLlTCMEDGLWSFPEALCE 645
Cdd:cd00033   10 GTVTGSKGSySYGSTVTYSCNEGYTLVGSSTI-TCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 587-644 1.84e-03

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 37.51  E-value: 1.84e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 578817525   587 CSIPDhhQVYAASFSCPEGT-TFGSQCSFQCRHPAQLKGNNSLlTCMEDGLWSFPEALC 644
Cdd:smart00032   1 CPPPP--DIENGTVTSSSGTySYGDTVTYSCDPGYTLIGSSTI-TCLENGTWSPPPPTC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 517-577 3.17e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 36.67  E-value: 3.17e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578817525 517 CPEL-AVENASLNCSSSDRYHGAQCTVSCRTGYVLQirrddeliksqtgPSVTVTCTE-GKWN 577
Cdd:cd00033    1 CPPPpVPENGTVTGSKGSYSYGSTVTYSCNEGYTLV-------------GSSTITCTEnGGWS 50
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 644-853 4.27e-03

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 40.02  E-value: 4.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817525 644 CELMCLAPPPVP-NADLQTA--RCRENKHKVGSFCKYKCKPGYhvpgssRKSKKRAFKTQCTQDGSWQEGACVPVTCDPP 720
Cdd:PHA02927  16 CVLSCCTIPSRPiNMKFKNSveTDANANYNIGDTIEYLCLPGY------RKQKMGPIYAKCTGTGWTLFNQCIKRRCPSP 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817525 721 PPKFHG-------------LYQCTNGFQFNSECRIKCEdsdasqgLGSNvihcrKDGTWNGSFHVCQEMqgQCSVPNELN 787
Cdd:PHA02927  90 RDIDNGqldiggvdfgssiTYSCNSGYQLIGESKSYCE-------LGST-----GSMVWNPEAPICESV--KCQSPPSIS 155

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578817525 788 SNLKLQCPDGYAIGSECATSCldhNSESIILPMNVTVRDIPHWLNPTRVERVVCtaglkwyPHPAL 853
Cdd:PHA02927 156 NGRHNGYEDFYTDGSVVTYSC---NSGYSLIGNSGVLCSGGEWSDPPTCQIVKC-------PHPTI 211
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 512-641 8.10e-03

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 39.25  E-value: 8.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817525 512 CEKTDCPEL-AVENASLNCSSSDRYHGAQCTVSCRTGYVLqirrddeliksqTGPSvTVTCTEGKWNKQVACEPVDCSIP 590
Cdd:PHA02927 143 CESVKCQSPpSISNGRHNGYEDFYTDGSVVTYSCNSGYSL------------IGNS-GVLCSGGEWSDPPTCQIVKCPHP 209

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 578817525 591 DHHQVYAASfSCPEGTTFGSQCSFQCRHPAQLKGNNSlLTCMEDGLWSfPE 641
Cdd:PHA02927 210 TISNGYLSS-GFKRSYSYNDNVDFKCKYGYKLSGSSS-STCSPGNTWQ-PE 257
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 560-773 9.42e-03

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 38.87  E-value: 9.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817525 560 KSQTGPsVTVTCTEGKWNKQVACEPVDCSIP---DHHQVYAAsfscpeGTTFGSQCSFQCRHPAQLKGNNSL---LTCME 633
Cdd:PHA02927  60 KQKMGP-IYAKCTGTGWTLFNQCIKRRCPSPrdiDNGQLDIG------GVDFGSSITYSCNSGYQLIGESKSyceLGSTG 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578817525 634 DGLWSFPEALCE-LMCLAPPPVPNAdlqTARCRENKHKVGSFCKYKCKPGYHVPGSSrkskkrafKTQCTqDGSWQE-GA 711
Cdd:PHA02927 133 SMVWNPEAPICEsVKCQSPPSISNG---RHNGYEDFYTDGSVVTYSCNSGYSLIGNS--------GVLCS-GGEWSDpPT 200

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 578817525 712 CVPVTCdpPPPKFHGLYqCTNGFQ----FNSECRIKCEDSDASQGLGSNVihCRKDGTWNGSFHVC 773
Cdd:PHA02927 201 CQIVKC--PHPTISNGY-LSSGFKrsysYNDNVDFKCKYGYKLSGSSSST--CSPGNTWQPELPKC 261
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 517-577 9.66e-03

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 35.19  E-value: 9.66e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 578817525   517 CPEL-AVENASLNCSSSDRYHGAQCTVSCRTGYVLQirrddeliksqtgPSVTVTCTE-GKWN 577
Cdd:smart00032   1 CPPPpDIENGTVTSSSGTYSYGDTVTYSCDPGYTLI-------------GSSTITCLEnGTWS 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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