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Conserved domains on  [gi|578813599|ref|XP_006715829|]
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radial spoke head 10 homolog B2 isoform X1 [Homo sapiens]

Protein Classification

MORN repeat-containing protein( domain architecture ID 11468649)

membrane-occupation-and-recognition-nexus (MORN) repeat-containing protein may be involved in protein-protein interactions

PubMed:  33296386|35568981

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
86-341 9.44e-43

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 157.04  E-value: 9.44e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599  86 YEGEKVRGLYEGEGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDFVKNVPMNHGVYTWPDGSMYEGEVVNGMRN 165
Cdd:COG4642   81 GGGGKGDGGDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPH 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599 166 GFGMFkcsTQP--VSYIGHWCNGKRHGKGSIYYnqegtcwyegdwvqnikkgwgircyKSGNIYEGQWEDNMRHGEGRMR 243
Cdd:COG4642  161 GQGTL---TYAdgDRYEGEFKNGKRHGQGTLTY-------------------------ANGDVYEGEFKNGQRHGQGTYT 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599 244 WlttneeytgrwergiQNGFgthtwflkrirssqyplrnEYIGEFVNGYRHGRGKFYYASGAMYDGEWVSNKKHGmffcl 323
Cdd:COG4642  213 Y---------------ADGD-------------------RYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHG----- 253

                        250
                 ....*....|....*...
gi 578813599 324 QGRLTFKNGRVYEGAFSN 341
Cdd:COG4642  254 QGTMTYADGSVYEGEWKN 271
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
86-341 9.44e-43

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 157.04  E-value: 9.44e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599  86 YEGEKVRGLYEGEGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDFVKNVPMNHGVYTWPDGSMYEGEVVNGMRN 165
Cdd:COG4642   81 GGGGKGDGGDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPH 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599 166 GFGMFkcsTQP--VSYIGHWCNGKRHGKGSIYYnqegtcwyegdwvqnikkgwgircyKSGNIYEGQWEDNMRHGEGRMR 243
Cdd:COG4642  161 GQGTL---TYAdgDRYEGEFKNGKRHGQGTLTY-------------------------ANGDVYEGEFKNGQRHGQGTYT 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599 244 WlttneeytgrwergiQNGFgthtwflkrirssqyplrnEYIGEFVNGYRHGRGKFYYASGAMYDGEWVSNKKHGmffcl 323
Cdd:COG4642  213 Y---------------ADGD-------------------RYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHG----- 253

                        250
                 ....*....|....*...
gi 578813599 324 QGRLTFKNGRVYEGAFSN 341
Cdd:COG4642  254 QGTMTYADGSVYEGEWKN 271
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 128-318 9.11e-28

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 120.32  E-value: 9.11e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599 128 DGLKYEGDFVKNVPMNHGVYTWPDGSMYEGEVVNGMRNGFGMFKCSTQpVSYIGHWCNGKRHGKGSiYYNQEGTCwYEGD 207
Cdd:PLN03185   7 NGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSG-ATYEGEFSGGYMHGSGT-YTGTDGTT-YKGR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599 208 WVQNIKKGWGIRCYKSGNIYEGQWEDNMRHGEGRMRWLTTNeEYTGRWERGIQNGFGTHTWFLKrirssqyplrNEYIGE 287
Cdd:PLN03185  84 WRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGN-VYLGDMKGGKMSGKGTLTWVSG----------DSYEGQ 152

                        170       180       190
                 ....*....|....*....|....*....|.
gi 578813599 288 FVNGYRHGRGKFYYASGAMYDGEWVSNKKHG 318
Cdd:PLN03185 153 WLDGMMHGFGVYTWSDGGCYVGTWTRGLKDG 183
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
225-244 8.36e-05

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 40.02  E-value: 8.36e-05
                           10        20
                   ....*....|....*....|
gi 578813599   225 NIYEGQWEDNMRHGEGRMRW 244
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTY 20
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 109-129 8.36e-05

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 40.08  E-value: 8.36e-05
                          10        20
                  ....*....|....*....|.
gi 578813599  109 YRGMFSEGLMHGQGTYIWADG 129
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDG 21
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
86-341 9.44e-43

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 157.04  E-value: 9.44e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599  86 YEGEKVRGLYEGEGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDFVKNVPMNHGVYTWPDGSMYEGEVVNGMRN 165
Cdd:COG4642   81 GGGGKGDGGDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPH 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599 166 GFGMFkcsTQP--VSYIGHWCNGKRHGKGSIYYnqegtcwyegdwvqnikkgwgircyKSGNIYEGQWEDNMRHGEGRMR 243
Cdd:COG4642  161 GQGTL---TYAdgDRYEGEFKNGKRHGQGTLTY-------------------------ANGDVYEGEFKNGQRHGQGTYT 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599 244 WlttneeytgrwergiQNGFgthtwflkrirssqyplrnEYIGEFVNGYRHGRGKFYYASGAMYDGEWVSNKKHGmffcl 323
Cdd:COG4642  213 Y---------------ADGD-------------------RYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHG----- 253

                        250
                 ....*....|....*...
gi 578813599 324 QGRLTFKNGRVYEGAFSN 341
Cdd:COG4642  254 QGTMTYADGSVYEGEWKN 271
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
59-256 8.48e-41

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 151.26  E-value: 8.48e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599  59 KDRQNVQQNEDASQYEESILTKLIVESYEGEKVRGLYEGEGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDFVK 138
Cdd:COG4642   77 GGGGGGGGKGDGGDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKN 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599 139 NVPMNHGVYTWPDGSMYEGEVVNGMRNGFGMFKCSTQpVSYIGHWCNGKRHGKGSIYYNQEGTcwYEGDWVQNIKKGWGI 218
Cdd:COG4642  157 GKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANG-DVYEGEFKNGQRHGQGTYTYADGDR--YEGEFKNGKRHGQGT 233

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 578813599 219 RCYKSGNIYEGQWEDNMRHGEGRMRWLTTnEEYTGRWE 256
Cdd:COG4642  234 LTYADGDRYEGEFKNGKRHGQGTMTYADG-SVYEGEWK 270
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
97-346 1.73e-37

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 141.63  E-value: 1.73e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599  97 GEGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDFVKNVPMNHGVYTWPDGSMYEGEVVNGMRNG---------- 166
Cdd:COG4642   11 GGGDATALGGGGEGGLAAAGGEGGGGLGTLPGGGGYGGGADGGGGGGGGTGVAGGGGGEGGVTAAGGGGGggggkgdggd 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599 167 --FGMFKCSTQPVSYIGHWCNGKRHGKGSIYYNQEGtcwYEGDWVQNIKKGWGIRCYKSGNIYEGQWEDNMRHGEGRMRW 244
Cdd:COG4642   91 ggGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGG---YGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTY 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599 245 lTTNEEYTGRWERGIQNGFGTHTWflkrirssqyPLRNEYIGEFVNGYRHGRGKFYYASGAMYDGEWVSNKKHGmffclQ 324
Cdd:COG4642  168 -ADGDRYEGEFKNGKRHGQGTLTY----------ANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHG-----Q 231

                        250       260
                 ....*....|....*....|..
gi 578813599 325 GRLTFKNGRVYEGAFSNDHIAG 346
Cdd:COG4642  232 GTLTYADGDRYEGEFKNGKRHG 253
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 128-318 9.11e-28

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 120.32  E-value: 9.11e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599 128 DGLKYEGDFVKNVPMNHGVYTWPDGSMYEGEVVNGMRNGFGMFKCSTQpVSYIGHWCNGKRHGKGSiYYNQEGTCwYEGD 207
Cdd:PLN03185   7 NGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSG-ATYEGEFSGGYMHGSGT-YTGTDGTT-YKGR 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599 208 WVQNIKKGWGIRCYKSGNIYEGQWEDNMRHGEGRMRWLTTNeEYTGRWERGIQNGFGTHTWFLKrirssqyplrNEYIGE 287
Cdd:PLN03185  84 WRLNLKHGLGYQRYPNGDVFEGSWIQGLQEGPGKYTWANGN-VYLGDMKGGKMSGKGTLTWVSG----------DSYEGQ 152

                        170       180       190
                 ....*....|....*....|....*....|.
gi 578813599 288 FVNGYRHGRGKFYYASGAMYDGEWVSNKKHG 318
Cdd:PLN03185 153 WLDGMMHGFGVYTWSDGGCYVGTWTRGLKDG 183
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
133-347 9.40e-25

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 104.65  E-value: 9.40e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599 133 EGDFVKNVPMNHGVYTWPDGSMYEGEVVNGMRNGFGMFKCSTQPVSYIGHWCNGKRHGKGSIYYNQEGtcwYEGDWVQNI 212
Cdd:COG4642    1 GGSVAEDGAGGGGDATALGGGGEGGLAAAGGEGGGGLGTLPGGGGYGGGADGGGGGGGGTGVAGGGGG---EGGVTAAGG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599 213 KKGWGIRCYKSGNIYEGQWEDNMRHGEGRmrwLTTNEEYTGRWERGIQNGFGTHTWFLKRIRSSQ----YPLRNEYIGEF 288
Cdd:COG4642   78 GGGGGGGKGDGGDGGGGEGGFGGGGGGGG---GKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGgiytFPNGDVYEGEF 154

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 578813599 289 VNGYRHGRGKFYYASGAMYDGEWVSNKKHGmffclQGRLTFKNGRVYEGAFSNDHIAGF 347
Cdd:COG4642  155 KNGKPHGQGTLTYADGDRYEGEFKNGKRHG-----QGTLTYANGDVYEGEFKNGQRHGQ 208
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 86-265 3.83e-24

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 108.77  E-value: 3.83e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599  86 YEGEKVRGLYEGEGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDFVKNVPMNHGVYTWPDGSMYEGEVVNGMRN 165
Cdd:PLN03185  34 YEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLGYQRYPNGDVFEGSWIQGLQE 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599 166 GFGMFKCSTQPVsYIGHWCNGKRHGKGSIyynqegtcwyegDWVqnikkgwgircykSGNIYEGQWEDNMRHGEGRMRWl 245
Cdd:PLN03185 114 GPGKYTWANGNV-YLGDMKGGKMSGKGTL------------TWV-------------SGDSYEGQWLDGMMHGFGVYTW- 166

                        170       180
                 ....*....|....*....|
gi 578813599 246 TTNEEYTGRWERGIQNGFGT 265
Cdd:PLN03185 167 SDGGCYVGTWTRGLKDGKGV 186
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 204-339 5.02e-15

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 79.49  E-value: 5.02e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599 204 YEGDWVQNIKKGWGIRCYKSGNIYEGQWEDNMRHGEGRMRWlttneeytgrwergiqngfgthtwflkrirssqyPLRNE 283
Cdd:PLN03185  11 YSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISW----------------------------------PSGAT 56

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 578813599 284 YIGEFVNGYRHGRGKFYYASGAMYDGEWVSNKKHGmffclQGRLTFKNGRVYEGAF 339
Cdd:PLN03185  57 YEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHG-----LGYQRYPNGDVFEGSW 107
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 86-170 1.15e-12

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 71.79  E-value: 1.15e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599  86 YEGEKVRGLYEGEGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDFVKNVPMNHGVYTWPDGSMYEGEVVNGMRN 165
Cdd:PLN03185 103 FEGSWIQGLQEGPGKYTWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKD 182


                 ....*
gi 578813599 166 GFGMF 170
Cdd:PLN03185 183 GKGVF 187
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
84-138 3.18e-11

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 64.98  E-value: 3.18e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 578813599  84 ESYEGEKVRGLYEGEGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDFVK 138
Cdd:COG4642  217 DRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYADGSVYEGEWKN 271
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 279-347 4.29e-07

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 53.68  E-value: 4.29e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578813599 279 PLRNEYIGEFVNGYRHGRGKFYYASGAMYDGEWVSNKKHGmffclQGRLTFKNGRVYEGAFSNDHIAGF 347
Cdd:PLN03185   6 SNGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHG-----NGKISWPSGATYEGEFSGGYMHGS 69
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
225-244 8.36e-05

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 40.02  E-value: 8.36e-05
                           10        20
                   ....*....|....*....|
gi 578813599   225 NIYEGQWEDNMRHGEGRMRW 244
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTY 20
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 109-129 8.36e-05

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 40.08  E-value: 8.36e-05
                          10        20
                  ....*....|....*....|.
gi 578813599  109 YRGMFSEGLMHGQGTYIWADG 129
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDG 21
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
155-335 1.05e-04

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 43.52  E-value: 1.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599 155 YEGEVVNGMRNGFGMFKCSTQPVSYIGHWCNGKRHGKGSIYYNQEGTCWYEGDWvqniKKGWGIRCYKSGNI-YEGQWED 233
Cdd:COG2849   12 YLLSLKLKYELGDTLLEKNGYKSGVKEKTEDSYNEGGKLIKKKLGKGLGKYKKG----KLGEWKTYYPNGQLkSEGTYKN 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599 234 NMRHGEGRMRWlttneeytgrwergiQNGfgthtwflkRIRSsqyplrneyIGEFVNGYRHGRGKFYYASGA-MYDGEWV 312
Cdd:COG2849   88 GKLEGEWKEYY---------------ENG---------KLKS---------EGNYKNGKLHGEWKEYYENGKlKEEGNYK 134

                        170       180
                 ....*....|....*....|....*....
gi 578813599 313 SNKKHGM--FFCLQGRL----TFKNGRVY 335
Cdd:COG2849  135 NGKKDGVwkYYDENGKLvkeeEYKNGKKV 163
YwqK COG2849
Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];
53-208 1.88e-04

Antitoxin component YwqK of the YwqJK toxin-antitoxin module [Defense mechanisms];


Pssm-ID: 442097 [Multi-domain]  Cd Length: 163  Bit Score: 42.75  E-value: 1.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599  53 NEVKPKKDRQNVQQNEDASQYEESILTKLIVESYEGEKVRGLYEGEGFAAFQGGCTYRGMFSEGLMHGQGTYIWADG-LK 131
Cdd:COG2849    1 KKKEGLLKISKYLLSLKLKYELGDTLLEKNGYKSGVKEKTEDSYNEGGKLIKKKLGKGLGKYKKGKLGEWKTYYPNGqLK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578813599 132 YEGDFVKNVPmnHGVYT--WPDGSM-YEGEVVNGMRNGFGMFKCSTQPVSYIGHWCNGKRHGKgSIYYNQEGTCWYEGDW 208
Cdd:COG2849   81 SEGTYKNGKL--EGEWKeyYENGKLkSEGNYKNGKLHGEWKEYYENGKLKEEGNYKNGKKDGV-WKYYDENGKLVKEEEY 157
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
107-128 1.98e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 39.25  E-value: 1.98e-04
                           10        20
                   ....*....|....*....|..
gi 578813599   107 CTYRGMFSEGLMHGQGTYIWAD 128
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYAN 22
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 284-306 2.61e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 38.93  E-value: 2.61e-04
                          10        20
                  ....*....|....*....|...
gi 578813599  284 YIGEFVNGYRHGRGKFYYASGAM 306
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 132-154 7.66e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 37.39  E-value: 7.66e-04
                          10        20
                  ....*....|....*....|...
gi 578813599  132 YEGDFVKNVPMNHGVYTWPDGSM 154
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
282-302 8.36e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 37.32  E-value: 8.36e-04
                           10        20
                   ....*....|....*....|.
gi 578813599   282 NEYIGEFVNGYRHGRGKFYYA 302
Cdd:smart00698   1 DRYEGEWRNGKRHGRGVYTYA 21
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 227-244 3.27e-03

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 35.46  E-value: 3.27e-03
                          10
                  ....*....|....*...
gi 578813599  227 YEGQWEDNMRHGEGRMRW 244
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTW 18
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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