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Conserved domains on  [gi|578805125|ref|XP_006712896|]
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coiled-coil domain-containing protein 74B isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CCDC74_C super family cl20803
Coiled coil protein 74, C terminal; This is a C-terminal conserved domain of coiled-coil ...
 308-423 5.65e-43

Coiled coil protein 74, C terminal; This is a C-terminal conserved domain of coiled-coil proteins from vertebrates. The function is not known. Expression levels in humans are elevated in breast cancer.


The actual alignment was detected with superfamily member pfam14917:

Pssm-ID: 464373  Cd Length: 123  Bit Score: 146.87  E-value: 5.65e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805125  308 LPLPLRKPTTLRQCEVLIRELWNTNLLQTQELQHLKSLLEGSQR-----PQAVPEEASFPRDQEATHFPKVSTKSLSKKC 382
Cdd:pfam14917   2 LPPHAPRPPTLQECEVIIRQLWNANSLQAQELQHLKSDLRESQNsskwtSDGYLLGKSYPKDQDAIQLPKVPLKGQSVKC 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 578805125  383 LLLSP-PVAERAILPALKQTPKNNFAERQKRLQAMQKRRLHR 423
Cdd:pfam14917  82 LALSPaPVAERVILPALKQTLNNNFAERRKRQQAVQRRRLHR 123
CCDC92 super family cl20802
Coiled-coil domain of unknown function; This domain family is found in eukaryotes, and is ...
 47-84 2.16e-10

Coiled-coil domain of unknown function; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The function is not known and the proteins carry no other domains.


The actual alignment was detected with superfamily member pfam14916:

Pssm-ID: 464372 [Multi-domain]  Cd Length: 57  Bit Score: 55.76  E-value: 2.16e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 578805125   47 QKRNLDLEKSLQFLQQQHSEMLAKLHEEIEHLKRENKG 84
Cdd:pfam14916   1 EQRLQSLEKSILFLQQQHAATLKGLHKEIERLQKENKD 38
 
Name Accession Description Interval E-value
CCDC74_C pfam14917
Coiled coil protein 74, C terminal; This is a C-terminal conserved domain of coiled-coil ...
 308-423 5.65e-43

Coiled coil protein 74, C terminal; This is a C-terminal conserved domain of coiled-coil proteins from vertebrates. The function is not known. Expression levels in humans are elevated in breast cancer.


Pssm-ID: 464373  Cd Length: 123  Bit Score: 146.87  E-value: 5.65e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805125  308 LPLPLRKPTTLRQCEVLIRELWNTNLLQTQELQHLKSLLEGSQR-----PQAVPEEASFPRDQEATHFPKVSTKSLSKKC 382
Cdd:pfam14917   2 LPPHAPRPPTLQECEVIIRQLWNANSLQAQELQHLKSDLRESQNsskwtSDGYLLGKSYPKDQDAIQLPKVPLKGQSVKC 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 578805125  383 LLLSP-PVAERAILPALKQTPKNNFAERQKRLQAMQKRRLHR 423
Cdd:pfam14917  82 LALSPaPVAERVILPALKQTLNNNFAERRKRQQAVQRRRLHR 123
CCDC92 pfam14916
Coiled-coil domain of unknown function; This domain family is found in eukaryotes, and is ...
 47-84 2.16e-10

Coiled-coil domain of unknown function; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The function is not known and the proteins carry no other domains.


Pssm-ID: 464372 [Multi-domain]  Cd Length: 57  Bit Score: 55.76  E-value: 2.16e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 578805125   47 QKRNLDLEKSLQFLQQQHSEMLAKLHEEIEHLKRENKG 84
Cdd:pfam14916   1 EQRLQSLEKSILFLQQQHAATLKGLHKEIERLQKENKD 38
 
Name Accession Description Interval E-value
CCDC74_C pfam14917
Coiled coil protein 74, C terminal; This is a C-terminal conserved domain of coiled-coil ...
 308-423 5.65e-43

Coiled coil protein 74, C terminal; This is a C-terminal conserved domain of coiled-coil proteins from vertebrates. The function is not known. Expression levels in humans are elevated in breast cancer.


Pssm-ID: 464373  Cd Length: 123  Bit Score: 146.87  E-value: 5.65e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578805125  308 LPLPLRKPTTLRQCEVLIRELWNTNLLQTQELQHLKSLLEGSQR-----PQAVPEEASFPRDQEATHFPKVSTKSLSKKC 382
Cdd:pfam14917   2 LPPHAPRPPTLQECEVIIRQLWNANSLQAQELQHLKSDLRESQNsskwtSDGYLLGKSYPKDQDAIQLPKVPLKGQSVKC 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 578805125  383 LLLSP-PVAERAILPALKQTPKNNFAERQKRLQAMQKRRLHR 423
Cdd:pfam14917  82 LALSPaPVAERVILPALKQTLNNNFAERRKRQQAVQRRRLHR 123
CCDC92 pfam14916
Coiled-coil domain of unknown function; This domain family is found in eukaryotes, and is ...
 47-84 2.16e-10

Coiled-coil domain of unknown function; This domain family is found in eukaryotes, and is approximately 60 amino acids in length. The function is not known and the proteins carry no other domains.


Pssm-ID: 464372 [Multi-domain]  Cd Length: 57  Bit Score: 55.76  E-value: 2.16e-10
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 578805125   47 QKRNLDLEKSLQFLQQQHSEMLAKLHEEIEHLKRENKG 84
Cdd:pfam14916   1 EQRLQSLEKSILFLQQQHAATLKGLHKEIERLQKENKD 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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