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histone deacetylase complex subunit SAP130 isoform X8 [Homo sapiens]
Protein Classification
List of domain hits
Name
Accession
Description
Interval
E-value
SAP130_C
pfam16014 Histone deacetylase complex subunit SAP130 C-terminus;
660-1030
0e+00
Histone deacetylase complex subunit SAP130 C-terminus;
Pssm-ID: 464973 [Multi-domain]
Cd Length: 371
Bit Score: 576.88
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 660 A Q GSSPRPSILRKKPAT D GAKPK SE IHV SM A T PVTV SM E TVSN QN ND Q P T IAVP P TA Q Q P PPT IPT MI A A A S PPSQP A V A 739
Cdd:pfam16014 1 A L GSSPRPSILRKKPAT E GAKPK PD IHV AV A P PVTV AV E ALPG QN SE Q Q T ASAS P PS Q H P AQA IPT IL A P A A PPSQP S V V 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 740 LST I P G A VPI TPPI T --- TIAA APP PSVTVGGSLSSVLGPPV PEIK V K E E V EPMD IMR pvs A VPPL ATNTV SP S L AL LAN 816
Cdd:pfam16014 81 LST L P A A MAV TPPI P asm ANVV APP TQPAASSTAACAVSSVL PEIK I K Q E A EPMD TSQ --- S VPPL TPTSI SP A L TS LAN 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 817 NLS M P TS DL P PGASPRKKPRKQQHVISTEEG D MMETNSTD D EKS TA K S L LVK AEKRKSPPKEYIDEEGVRYVPVRPRPPI 896
Cdd:pfam16014 158 NLS V P AG DL L PGASPRKKPRKQQHVISTEEG E MMETNSTD E EKS AP K P L TSR AEKRKSPPKEYIDEEGVRYVPVRPRPPI 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 897 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK AM LQ EI ANQKGV S CRAQGWK V HLCAAQLLQLTNLEHDVY E RLT N LQEG I I 976
Cdd:pfam16014 238 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK GT LQ DM ANQKGV T CRAQGWK I HLCAAQLLQLTNLEHDVY S RLT T LQEG L I 317
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 578804896 977 PKKKA A TDDDLHRINELIQGNMQRCKLVMDQI S EARDSM L KVLDHKDRVLKLLN 1030
Cdd:pfam16014 318 PKKKA G TDDDLHRINELIQGNMQRCKLVMDQI T EARDSM M KVLDHKDRVLKLLN 371
PHA03247 super family
cl33720 large tegument protein UL36; Provisional
45-365
1.91e-05
large tegument protein UL36; Provisional
PHA03247 :Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 49.17
E-value: 1.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 45 A PS QIANSGSAGLIN P AATVND E SG RD SEVSA R EHMSSSSSLQS R EEKQEPVVV RP YPQVQMLSTHHAVAS A T P VAVTAP 124
Cdd:PHA03247 2628 P PS PSPAANEPDPHP P PTVPPP E RP RD DPAPG R VSRPRRARRLG R AAQASSPPQ RP RRRAARPTVGSLTSL A D P PPPPPT 2707
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 125 P AHLTP A VPLSFSEGLMKPPPKPTM P SR P I APAPP STLS l P P KV PG QVTVTMESSIPQASAI P VATISGQQ G H P SN L HHI 204
Cdd:PHA03247 2708 P EPAPH A LVSATPLPPGPAAARQAS P AL P A APAPP AVPA - G P AT PG GPARPARPPTTAGPPA P APPAAPAA G P P RR L TRP 2786
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 205 MTTNVQM S IIRSNA P GP P LHIG A SH L PR gaaaaavms SSKVTTVLR P TSQ LP NAAT AQP AVQHIIHQ P IQ sr P PVTTSNA 284
Cdd:PHA03247 2787 AVASLSE S RESLPS P WD P ADPP A AV L AP --------- AAALPPAAS P AGP LP PPTS AQP TAPPPPPG P PP -- P SLPLGGS 2855
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 285 IP P AVVATVSATRAQSPVITTTA A HATDSA L S RP TL S IQHPPS A -- AISIQ RP A Q SRDVTTRITL P SH P ALGT P KQQLHT 362
Cdd:PHA03247 2856 VA P GGDVRRRPPSRSPAAKPAAP A RPPVRR L A RP AV S RSTESF A lp PDQPE RP P Q PQAPPPPQPQ P QP P PPPQ P QPPPPP 2935
...
gi 578804896 363 MAQ 365
Cdd:PHA03247 2936 PPR 2938
PHA03247 super family
cl33720 large tegument protein UL36; Provisional
373-876
5.25e-05
large tegument protein UL36; Provisional
PHA03247 :Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 47.63
E-value: 5.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 373 T P VAAATVA P ILATNTI P SATT A GSV S HTQAPTSTIVTMTV P SHSSHATA V TTSNI P VAKVV P QQITHTSPRIQ P DY P AE 452
Cdd:PHA03247 2552 P P PLPPAAP P AAPDRSV P PPRP A PRP S EPAVTSRARRPDAP P QSARPRAP V DDRGD P RGPAP P SPLPPDTHAPD P PP P SP 2631
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 453 RSSLIPISG H RASPN P VAMET R S D NR P S ------- VPVQFQYFLPTY PP SAY -- PL A AH T YTPI TS SVSTIRQY P VSAQ A 523
Cdd:PHA03247 2632 SPAANEPDP H PPPTV P PPERP R D D PA P G rvsrprr ARRLGRAAQASS PP QRP rr RA A RP T VGSL TS LADPPPPP P TPEP A 2711
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 524 P NSAIT A QTGVGVASTVHLNPMQ L MTVD A SH A RHIQGIQ P APISTQGIQ P API G T P GIQ P -- AP LGTQGIHSAT P INTQG 601
Cdd:PHA03247 2712 P HALVS A TPLPPGPAAARQASPA L PAAP A PP A VPAGPAT P GGPARPARP P TTA G P P APA P pa AP AAGPPRRLTR P AVASL 2791
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 602 LQPAPMGTQQPQ P EGKTSV VLA DG A TI va N P ISN P FSAA P AA T TVVQ T HSQ ----- SASTNAPAQGSS P RPSIL R KK P A - 675
Cdd:PHA03247 2792 SESRESLPSPWD P ADPPAA VLA PA A AL -- P P AAS P AGPL P PP T SAQP T APP pppgp PPPSLPLGGSVA P GGDVR R RP P S r 2869
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 676 TDG AKP KSEIHV --- SM A T P VT vsme TV S NQNNDQ P TIAVPPTA Q QPP P TI P TMIAAAS PP S QP AVALSTI P GAV P ITP P 752
Cdd:PHA03247 2870 SPA AKP AAPARP pvr RL A R P AV ---- SR S TESFAL P PDQPERPP Q PQA P PP P QPQPQPP PP P QP QPPPPPP P RPQ P PLA P 2945
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 753 I T TI A A A PP PS VT V GGSLSSV L G P --- P VP EIK V KEEVEPMDI mr P V S AV PPL a T NTVSPSLALL A NN L SMPTSDL PP GA 829
Cdd:PHA03247 2946 T T DP A G A GE PS GA V PQPWLGA L V P grv A VP RFR V PQPAPSREA -- P A S ST PPL - T GHSLSRVSSW A SS L ALHEETD PP PV 3022
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 578804896 830 S prkkp R KQ QHVIS -- TE EG D MMETNST D D E K S TAKS L LVKAEKRKS P P 876
Cdd:PHA03247 3023 S ----- L KQ TLWPP dd TE DS D ADSLFDS D S E R S DLEA L DPLPPEPHD P F 3066
Name
Accession
Description
Interval
E-value
SAP130_C
pfam16014 Histone deacetylase complex subunit SAP130 C-terminus;
660-1030
0e+00
Histone deacetylase complex subunit SAP130 C-terminus;
Pssm-ID: 464973 [Multi-domain]
Cd Length: 371
Bit Score: 576.88
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 660 A Q GSSPRPSILRKKPAT D GAKPK SE IHV SM A T PVTV SM E TVSN QN ND Q P T IAVP P TA Q Q P PPT IPT MI A A A S PPSQP A V A 739
Cdd:pfam16014 1 A L GSSPRPSILRKKPAT E GAKPK PD IHV AV A P PVTV AV E ALPG QN SE Q Q T ASAS P PS Q H P AQA IPT IL A P A A PPSQP S V V 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 740 LST I P G A VPI TPPI T --- TIAA APP PSVTVGGSLSSVLGPPV PEIK V K E E V EPMD IMR pvs A VPPL ATNTV SP S L AL LAN 816
Cdd:pfam16014 81 LST L P A A MAV TPPI P asm ANVV APP TQPAASSTAACAVSSVL PEIK I K Q E A EPMD TSQ --- S VPPL TPTSI SP A L TS LAN 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 817 NLS M P TS DL P PGASPRKKPRKQQHVISTEEG D MMETNSTD D EKS TA K S L LVK AEKRKSPPKEYIDEEGVRYVPVRPRPPI 896
Cdd:pfam16014 158 NLS V P AG DL L PGASPRKKPRKQQHVISTEEG E MMETNSTD E EKS AP K P L TSR AEKRKSPPKEYIDEEGVRYVPVRPRPPI 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 897 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK AM LQ EI ANQKGV S CRAQGWK V HLCAAQLLQLTNLEHDVY E RLT N LQEG I I 976
Cdd:pfam16014 238 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK GT LQ DM ANQKGV T CRAQGWK I HLCAAQLLQLTNLEHDVY S RLT T LQEG L I 317
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 578804896 977 PKKKA A TDDDLHRINELIQGNMQRCKLVMDQI S EARDSM L KVLDHKDRVLKLLN 1030
Cdd:pfam16014 318 PKKKA G TDDDLHRINELIQGNMQRCKLVMDQI T EARDSM M KVLDHKDRVLKLLN 371
PHA03247
PHA03247 large tegument protein UL36; Provisional
45-365
1.91e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 49.17
E-value: 1.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 45 A PS QIANSGSAGLIN P AATVND E SG RD SEVSA R EHMSSSSSLQS R EEKQEPVVV RP YPQVQMLSTHHAVAS A T P VAVTAP 124
Cdd:PHA03247 2628 P PS PSPAANEPDPHP P PTVPPP E RP RD DPAPG R VSRPRRARRLG R AAQASSPPQ RP RRRAARPTVGSLTSL A D P PPPPPT 2707
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 125 P AHLTP A VPLSFSEGLMKPPPKPTM P SR P I APAPP STLS l P P KV PG QVTVTMESSIPQASAI P VATISGQQ G H P SN L HHI 204
Cdd:PHA03247 2708 P EPAPH A LVSATPLPPGPAAARQAS P AL P A APAPP AVPA - G P AT PG GPARPARPPTTAGPPA P APPAAPAA G P P RR L TRP 2786
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 205 MTTNVQM S IIRSNA P GP P LHIG A SH L PR gaaaaavms SSKVTTVLR P TSQ LP NAAT AQP AVQHIIHQ P IQ sr P PVTTSNA 284
Cdd:PHA03247 2787 AVASLSE S RESLPS P WD P ADPP A AV L AP --------- AAALPPAAS P AGP LP PPTS AQP TAPPPPPG P PP -- P SLPLGGS 2855
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 285 IP P AVVATVSATRAQSPVITTTA A HATDSA L S RP TL S IQHPPS A -- AISIQ RP A Q SRDVTTRITL P SH P ALGT P KQQLHT 362
Cdd:PHA03247 2856 VA P GGDVRRRPPSRSPAAKPAAP A RPPVRR L A RP AV S RSTESF A lp PDQPE RP P Q PQAPPPPQPQ P QP P PPPQ P QPPPPP 2935
...
gi 578804896 363 MAQ 365
Cdd:PHA03247 2936 PPR 2938
PHA03247
PHA03247 large tegument protein UL36; Provisional
373-876
5.25e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 47.63
E-value: 5.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 373 T P VAAATVA P ILATNTI P SATT A GSV S HTQAPTSTIVTMTV P SHSSHATA V TTSNI P VAKVV P QQITHTSPRIQ P DY P AE 452
Cdd:PHA03247 2552 P P PLPPAAP P AAPDRSV P PPRP A PRP S EPAVTSRARRPDAP P QSARPRAP V DDRGD P RGPAP P SPLPPDTHAPD P PP P SP 2631
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 453 RSSLIPISG H RASPN P VAMET R S D NR P S ------- VPVQFQYFLPTY PP SAY -- PL A AH T YTPI TS SVSTIRQY P VSAQ A 523
Cdd:PHA03247 2632 SPAANEPDP H PPPTV P PPERP R D D PA P G rvsrprr ARRLGRAAQASS PP QRP rr RA A RP T VGSL TS LADPPPPP P TPEP A 2711
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 524 P NSAIT A QTGVGVASTVHLNPMQ L MTVD A SH A RHIQGIQ P APISTQGIQ P API G T P GIQ P -- AP LGTQGIHSAT P INTQG 601
Cdd:PHA03247 2712 P HALVS A TPLPPGPAAARQASPA L PAAP A PP A VPAGPAT P GGPARPARP P TTA G P P APA P pa AP AAGPPRRLTR P AVASL 2791
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 602 LQPAPMGTQQPQ P EGKTSV VLA DG A TI va N P ISN P FSAA P AA T TVVQ T HSQ ----- SASTNAPAQGSS P RPSIL R KK P A - 675
Cdd:PHA03247 2792 SESRESLPSPWD P ADPPAA VLA PA A AL -- P P AAS P AGPL P PP T SAQP T APP pppgp PPPSLPLGGSVA P GGDVR R RP P S r 2869
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 676 TDG AKP KSEIHV --- SM A T P VT vsme TV S NQNNDQ P TIAVPPTA Q QPP P TI P TMIAAAS PP S QP AVALSTI P GAV P ITP P 752
Cdd:PHA03247 2870 SPA AKP AAPARP pvr RL A R P AV ---- SR S TESFAL P PDQPERPP Q PQA P PP P QPQPQPP PP P QP QPPPPPP P RPQ P PLA P 2945
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 753 I T TI A A A PP PS VT V GGSLSSV L G P --- P VP EIK V KEEVEPMDI mr P V S AV PPL a T NTVSPSLALL A NN L SMPTSDL PP GA 829
Cdd:PHA03247 2946 T T DP A G A GE PS GA V PQPWLGA L V P grv A VP RFR V PQPAPSREA -- P A S ST PPL - T GHSLSRVSSW A SS L ALHEETD PP PV 3022
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 578804896 830 S prkkp R KQ QHVIS -- TE EG D MMETNST D D E K S TAKS L LVKAEKRKS P P 876
Cdd:PHA03247 3023 S ----- L KQ TLWPP dd TE DS D ADSLFDS D S E R S DLEA L DPLPPEPHD P F 3066
Atrophin-1
pfam03154 Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
479-811
9.84e-04
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain]
Cd Length: 991
Bit Score: 43.22
E-value: 9.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 479 P SVPV Q FQYFL P TY PP SAYPLA A H T YT P IT S SV S TIR Q - Y P VSA Q A PN SAI - TA QTGVGVAS T VH L N P MQ L MTVDASHAR 556
Cdd:pfam03154 172 P VLQA Q SGAAS P PS PP PPGTTQ A A T AG P TP S AP S VPP Q g S P ATS Q P PN QTQ s TA APHTLIQQ T PT L H P QR L PSPHPPLQP 251
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 557 HI Q GIQ P API S T Q GIQPAPIGTPGI - Q P AP L G T QGI H SAT P INT Q GLQPA P MGT Q QPQ P E G KTSVVLADGATIVAN P I S N 635
Cdd:pfam03154 252 MT Q PPP P SQV S P Q PLPQPSLHGQMP p M P HS L Q T GPS H MQH P VPP Q PFPLT P QSS Q SQV P P G PSPAAPGQSQQRIHT P P S Q 331
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 636 PFSAA -------------------- P AA TT VVQTHSQSA S TNA P AQG S S P R P ---- S I L RKK PA TDGAKPK S EI H VSM A T 691
Cdd:pfam03154 332 SQLQS qqppreqplppaplsmphik P PP TT PIPQLPNPQ S HKH P PHL S G P S P fqmn S N L PPP PA LKPLSSL S TH H PPS A H 411
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 692 P VTVSMETV S N Q ---- NNDQ P TIAVPPTAQQ P PPTI P TMIAAASP PSQ PAVAL - STI PG AV P - ITPP ITTIAAAPP ---- 761
Cdd:pfam03154 412 P PPLQLMPQ S Q Q lppp PAQP P VLTQSQSLPP P AASH P PTSGLHQV PSQ SPFPQ h PFV PG GP P p ITPP SGPPTSTSS ampg 491
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 578804896 762 ------ P SV TVG G SLSSVLGP P V P EIKV KEE v EPMDIMR P V S AV PP LATNTVS P SL 811
Cdd:pfam03154 492 iqppss A SV SSS G PVPAAVSC P L P PVQI KEE - ALDEAEE P E S PP PP PRSPSPE P TV 546
PRK07003
PRK07003 DNA polymerase III subunit gamma/tau;
605-839
7.44e-03
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain]
Cd Length: 830
Bit Score: 40.22
E-value: 7.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 605 AP M G TQQPQPE G --- KTSVVL A DGATIV A N P ISNPFSA A PA A TTVVQTHSQS A S T N A P A QGSS P R P SILRKKPATDGAKP 681
Cdd:PRK07003 367 AP G G GVPARVA G avp APGARA A AAVGAS A V P AVTAVTG A AG A ALAPKAAAAA A A T R A E A PPAA P A P PATADRGDDAADGD 446
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 682 KS eih V SMATPVTV S METVSNQNND QP TIA vpptaqqpppti PTMIA A ASPPSQ P AV A LSTI P G A VPITPPITTIAAAP - 760
Cdd:PRK07003 447 AP --- V PAKANARA S ADSRCDERDA QP PAD ------------ SGSAS A PASDAP P DA A FEPA P R A AAPSAATPAAVPDA r 511
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578804896 761 P P SVTVGGSLSSVLG PP V PE IKVKE evepmdimr P VS A V P PLATNTVSPS L AL L A N NLSMPT SD LPPG A SPRK KP RKQQ 839
Cdd:PRK07003 512 A P AAASREDAPAAAA PP A PE ARPPT --------- P AA A A P AARAGGAAAA L DV L R N AGMRVS SD RGAR A AAAA KP AAAP 581
Name
Accession
Description
Interval
E-value
SAP130_C
pfam16014 Histone deacetylase complex subunit SAP130 C-terminus;
660-1030
0e+00
Histone deacetylase complex subunit SAP130 C-terminus;
Pssm-ID: 464973 [Multi-domain]
Cd Length: 371
Bit Score: 576.88
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 660 A Q GSSPRPSILRKKPAT D GAKPK SE IHV SM A T PVTV SM E TVSN QN ND Q P T IAVP P TA Q Q P PPT IPT MI A A A S PPSQP A V A 739
Cdd:pfam16014 1 A L GSSPRPSILRKKPAT E GAKPK PD IHV AV A P PVTV AV E ALPG QN SE Q Q T ASAS P PS Q H P AQA IPT IL A P A A PPSQP S V V 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 740 LST I P G A VPI TPPI T --- TIAA APP PSVTVGGSLSSVLGPPV PEIK V K E E V EPMD IMR pvs A VPPL ATNTV SP S L AL LAN 816
Cdd:pfam16014 81 LST L P A A MAV TPPI P asm ANVV APP TQPAASSTAACAVSSVL PEIK I K Q E A EPMD TSQ --- S VPPL TPTSI SP A L TS LAN 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 817 NLS M P TS DL P PGASPRKKPRKQQHVISTEEG D MMETNSTD D EKS TA K S L LVK AEKRKSPPKEYIDEEGVRYVPVRPRPPI 896
Cdd:pfam16014 158 NLS V P AG DL L PGASPRKKPRKQQHVISTEEG E MMETNSTD E EKS AP K P L TSR AEKRKSPPKEYIDEEGVRYVPVRPRPPI 237
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 897 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK AM LQ EI ANQKGV S CRAQGWK V HLCAAQLLQLTNLEHDVY E RLT N LQEG I I 976
Cdd:pfam16014 238 TLLRHYRNPWKAAYHHFQRYSDVRVKEEKK GT LQ DM ANQKGV T CRAQGWK I HLCAAQLLQLTNLEHDVY S RLT T LQEG L I 317
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 578804896 977 PKKKA A TDDDLHRINELIQGNMQRCKLVMDQI S EARDSM L KVLDHKDRVLKLLN 1030
Cdd:pfam16014 318 PKKKA G TDDDLHRINELIQGNMQRCKLVMDQI T EARDSM M KVLDHKDRVLKLLN 371
PHA03247
PHA03247 large tegument protein UL36; Provisional
45-365
1.91e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 49.17
E-value: 1.91e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 45 A PS QIANSGSAGLIN P AATVND E SG RD SEVSA R EHMSSSSSLQS R EEKQEPVVV RP YPQVQMLSTHHAVAS A T P VAVTAP 124
Cdd:PHA03247 2628 P PS PSPAANEPDPHP P PTVPPP E RP RD DPAPG R VSRPRRARRLG R AAQASSPPQ RP RRRAARPTVGSLTSL A D P PPPPPT 2707
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 125 P AHLTP A VPLSFSEGLMKPPPKPTM P SR P I APAPP STLS l P P KV PG QVTVTMESSIPQASAI P VATISGQQ G H P SN L HHI 204
Cdd:PHA03247 2708 P EPAPH A LVSATPLPPGPAAARQAS P AL P A APAPP AVPA - G P AT PG GPARPARPPTTAGPPA P APPAAPAA G P P RR L TRP 2786
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 205 MTTNVQM S IIRSNA P GP P LHIG A SH L PR gaaaaavms SSKVTTVLR P TSQ LP NAAT AQP AVQHIIHQ P IQ sr P PVTTSNA 284
Cdd:PHA03247 2787 AVASLSE S RESLPS P WD P ADPP A AV L AP --------- AAALPPAAS P AGP LP PPTS AQP TAPPPPPG P PP -- P SLPLGGS 2855
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 285 IP P AVVATVSATRAQSPVITTTA A HATDSA L S RP TL S IQHPPS A -- AISIQ RP A Q SRDVTTRITL P SH P ALGT P KQQLHT 362
Cdd:PHA03247 2856 VA P GGDVRRRPPSRSPAAKPAAP A RPPVRR L A RP AV S RSTESF A lp PDQPE RP P Q PQAPPPPQPQ P QP P PPPQ P QPPPPP 2935
...
gi 578804896 363 MAQ 365
Cdd:PHA03247 2936 PPR 2938
PHA03247
PHA03247 large tegument protein UL36; Provisional
373-876
5.25e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 47.63
E-value: 5.25e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 373 T P VAAATVA P ILATNTI P SATT A GSV S HTQAPTSTIVTMTV P SHSSHATA V TTSNI P VAKVV P QQITHTSPRIQ P DY P AE 452
Cdd:PHA03247 2552 P P PLPPAAP P AAPDRSV P PPRP A PRP S EPAVTSRARRPDAP P QSARPRAP V DDRGD P RGPAP P SPLPPDTHAPD P PP P SP 2631
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 453 RSSLIPISG H RASPN P VAMET R S D NR P S ------- VPVQFQYFLPTY PP SAY -- PL A AH T YTPI TS SVSTIRQY P VSAQ A 523
Cdd:PHA03247 2632 SPAANEPDP H PPPTV P PPERP R D D PA P G rvsrprr ARRLGRAAQASS PP QRP rr RA A RP T VGSL TS LADPPPPP P TPEP A 2711
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 524 P NSAIT A QTGVGVASTVHLNPMQ L MTVD A SH A RHIQGIQ P APISTQGIQ P API G T P GIQ P -- AP LGTQGIHSAT P INTQG 601
Cdd:PHA03247 2712 P HALVS A TPLPPGPAAARQASPA L PAAP A PP A VPAGPAT P GGPARPARP P TTA G P P APA P pa AP AAGPPRRLTR P AVASL 2791
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 602 LQPAPMGTQQPQ P EGKTSV VLA DG A TI va N P ISN P FSAA P AA T TVVQ T HSQ ----- SASTNAPAQGSS P RPSIL R KK P A - 675
Cdd:PHA03247 2792 SESRESLPSPWD P ADPPAA VLA PA A AL -- P P AAS P AGPL P PP T SAQP T APP pppgp PPPSLPLGGSVA P GGDVR R RP P S r 2869
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 676 TDG AKP KSEIHV --- SM A T P VT vsme TV S NQNNDQ P TIAVPPTA Q QPP P TI P TMIAAAS PP S QP AVALSTI P GAV P ITP P 752
Cdd:PHA03247 2870 SPA AKP AAPARP pvr RL A R P AV ---- SR S TESFAL P PDQPERPP Q PQA P PP P QPQPQPP PP P QP QPPPPPP P RPQ P PLA P 2945
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 753 I T TI A A A PP PS VT V GGSLSSV L G P --- P VP EIK V KEEVEPMDI mr P V S AV PPL a T NTVSPSLALL A NN L SMPTSDL PP GA 829
Cdd:PHA03247 2946 T T DP A G A GE PS GA V PQPWLGA L V P grv A VP RFR V PQPAPSREA -- P A S ST PPL - T GHSLSRVSSW A SS L ALHEETD PP PV 3022
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 578804896 830 S prkkp R KQ QHVIS -- TE EG D MMETNST D D E K S TAKS L LVKAEKRKS P P 876
Cdd:PHA03247 3023 S ----- L KQ TLWPP dd TE DS D ADSLFDS D S E R S DLEA L DPLPPEPHD P F 3066
PHA03247
PHA03247 large tegument protein UL36; Provisional
124-518
8.79e-05
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain]
Cd Length: 3151
Bit Score: 46.86
E-value: 8.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 124 PP AH L T PA --------- VP LSFSEGLMKP P PKPTMPS RP I AP APPSTLSL P PKVP G QVTVTMES S - I P QASAI P VATISG 193
Cdd:PHA03247 2551 PP PP L P PA appaapdrs VP PPRPAPRPSE P AVTSRAR RP D AP PQSARPRA P VDDR G DPRGPAPP S p L P PDTHA P DPPPPS 2630
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 194 QQGHPSNLHHIMTTN V QMSIIRSNA P G P P ------------ LHIG AS HL P RGAAAA A VMSS - SKV T TVLR P TSQL P NAAT 260
Cdd:PHA03247 2631 PSPAANEPDPHPPPT V PPPERPRDD P A P G rvsrprrarrlg RAAQ AS SP P QRPRRR A ARPT v GSL T SLAD P PPPP P TPEP 2710
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 261 A QP A VQHIIHQ P IQSRPPVTT S N A I P P A VVATVSATRAQS P V - ITTT A AHA T DSALSR P TLSIQHPPSAAISIQ RPA QSR 339
Cdd:PHA03247 2711 A PH A LVSATPL P PGPAAARQA S P A L P A A PAPPAVPAGPAT P G g PARP A RPP T TAGPPA P APPAAPAAGPPRRLT RPA VAS 2790
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 340 DVTT R IT LPS ------ H PA LGTPKQQLHTM A QKTIFSTGT P VA A ATV AP ILATNTI P SATTA G SVSHTQAP tsti V TMTV 413
Cdd:PHA03247 2791 LSES R ES LPS pwdpad P PA AVLAPAAALPP A ASPAGPLPP P TS A QPT AP PPPPGPP P PSLPL G GSVAPGGD ---- V RRRP 2866
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 414 PS H S SH A TAVTTSNI PV AKV vpqqithts P R IQPDYPA E RSS L I P ISGH R ASPNPVAMETRSDNR P SV P V Q F Q YFL P TY P 493
Cdd:PHA03247 2867 PS R S PA A KPAAPARP PV RRL --------- A R PAVSRST E SFA L P P DQPE R PPQPQAPPPPQPQPQ P PP P P Q P Q PPP P PP P 2937
410 420
....*....|....*....|....*
gi 578804896 494 PSAY PLA AH T YTPITSSV S TIRQY P 518
Cdd:PHA03247 2938 RPQP PLA PT T DPAGAGEP S GAVPQ P 2962
Atrophin-1
pfam03154 Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
479-811
9.84e-04
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain]
Cd Length: 991
Bit Score: 43.22
E-value: 9.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 479 P SVPV Q FQYFL P TY PP SAYPLA A H T YT P IT S SV S TIR Q - Y P VSA Q A PN SAI - TA QTGVGVAS T VH L N P MQ L MTVDASHAR 556
Cdd:pfam03154 172 P VLQA Q SGAAS P PS PP PPGTTQ A A T AG P TP S AP S VPP Q g S P ATS Q P PN QTQ s TA APHTLIQQ T PT L H P QR L PSPHPPLQP 251
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 557 HI Q GIQ P API S T Q GIQPAPIGTPGI - Q P AP L G T QGI H SAT P INT Q GLQPA P MGT Q QPQ P E G KTSVVLADGATIVAN P I S N 635
Cdd:pfam03154 252 MT Q PPP P SQV S P Q PLPQPSLHGQMP p M P HS L Q T GPS H MQH P VPP Q PFPLT P QSS Q SQV P P G PSPAAPGQSQQRIHT P P S Q 331
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 636 PFSAA -------------------- P AA TT VVQTHSQSA S TNA P AQG S S P R P ---- S I L RKK PA TDGAKPK S EI H VSM A T 691
Cdd:pfam03154 332 SQLQS qqppreqplppaplsmphik P PP TT PIPQLPNPQ S HKH P PHL S G P S P fqmn S N L PPP PA LKPLSSL S TH H PPS A H 411
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 692 P VTVSMETV S N Q ---- NNDQ P TIAVPPTAQQ P PPTI P TMIAAASP PSQ PAVAL - STI PG AV P - ITPP ITTIAAAPP ---- 761
Cdd:pfam03154 412 P PPLQLMPQ S Q Q lppp PAQP P VLTQSQSLPP P AASH P PTSGLHQV PSQ SPFPQ h PFV PG GP P p ITPP SGPPTSTSS ampg 491
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 578804896 762 ------ P SV TVG G SLSSVLGP P V P EIKV KEE v EPMDIMR P V S AV PP LATNTVS P SL 811
Cdd:pfam03154 492 iqppss A SV SSS G PVPAAVSC P L P PVQI KEE - ALDEAEE P E S PP PP PRSPSPE P TV 546
PRK07003
PRK07003 DNA polymerase III subunit gamma/tau;
605-839
7.44e-03
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain]
Cd Length: 830
Bit Score: 40.22
E-value: 7.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 605 AP M G TQQPQPE G --- KTSVVL A DGATIV A N P ISNPFSA A PA A TTVVQTHSQS A S T N A P A QGSS P R P SILRKKPATDGAKP 681
Cdd:PRK07003 367 AP G G GVPARVA G avp APGARA A AAVGAS A V P AVTAVTG A AG A ALAPKAAAAA A A T R A E A PPAA P A P PATADRGDDAADGD 446
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578804896 682 KS eih V SMATPVTV S METVSNQNND QP TIA vpptaqqpppti PTMIA A ASPPSQ P AV A LSTI P G A VPITPPITTIAAAP - 760
Cdd:PRK07003 447 AP --- V PAKANARA S ADSRCDERDA QP PAD ------------ SGSAS A PASDAP P DA A FEPA P R A AAPSAATPAAVPDA r 511
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 578804896 761 P P SVTVGGSLSSVLG PP V PE IKVKE evepmdimr P VS A V P PLATNTVSPS L AL L A N NLSMPT SD LPPG A SPRK KP RKQQ 839
Cdd:PRK07003 512 A P AAASREDAPAAAA PP A PE ARPPT --------- P AA A A P AARAGGAAAA L DV L R N AGMRVS SD RGAR A AAAA KP AAAP 581
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
