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Conserved domains on  [gi|571500055|ref|XP_006594576|]
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receptor-like protein 4 isoform X2 [Glycine max]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PLN03150 super family cl31977
hypothetical protein; Provisional
 10-584 0e+00

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03150:

Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 989.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055  10 LLLWMLFLC--FACTARAAQRGPFAMRISCGARQNVQTKPTTTLWYKDFGYTGGIPTNAKTSSYIAPPLKTLRYFPLSEG 87
Cdd:PLN03150   1 LRLWLLAASalLAVLASLASPEPFTMRISCGARVNVRTAPTNTLWYKDFAYTGGIPANATRPSFIAPPLKTLRYFPLSDG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055  88 PSNCYNINRVPKGHYSIRIFFGLVAQARATDEPLFDISIQGTQIYSLKSGWTTQDDQAFTEA------------------ 149
Cdd:PLN03150  81 PENCYNINRVPKGHYSVRVFFGLVAEPNFDSEPLFDVSVEGTQISSLKSGWSSHDEQVFAEAlvfltdgsasicfhstgh 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 150 ----------------------QWSQGIILRTVKRLSCGFGQSKYGVDYGADPRGGDRFWQHTETFGEDSDRPRSVETRI 207
Cdd:PLN03150 161 gdpailsieilqvddkaynfgpSWGQGVILRTAKRLSCGAGKSKFDEDYSGDHWGGDRFWNRMQTFGSGSDQAISTENVI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 208 KQASHPPNFYPETLYRSALVSTSSQPELTYTLDVDPNKNYSVWLHFAEIDNSVTAEGQRVFDIMINGDVAFKDVDIVKLS 287
Cdd:PLN03150 241 KKASNAPNFYPESLYQSALVSTDTQPDLSYTMDVDPNRNYSVWLHFAEIDNSITAEGKRVFDVLINGDTAFKDVDIVKMS 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 288 GDRYTALVLNTTVVVNGRTLTIALSPKDGSFAIINAIEIMEVIMAESKTLSDEVMALQKLKKALGLPPRFGWNGDPCVPQ 367
Cdd:PLN03150 321 GERYTALVLNKTVAVSGRTLTIVLQPKKGTHAIINAIEVFEIITAESKTLLEEVSALQTLKSSLGLPLRFGWNGDPCVPQ 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 368 QHPWTGADCRLDKSSSKWVIDGLGLDNQGLKGFLPNDISRLHNLQILNLSGNSIQGPIPSPLGTIASLQVLDLSYNFFNG 447
Cdd:PLN03150 401 QHPWSGADCQFDSTKGKWFIDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNG 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 448 SIPESLGQLTSLQRLNLNGNFLSGRVPATLGGRLLHGASFNFTDNAGLCGIPGLPTCGPHLSAGAKVGIGLGVSFTLLLL 527
Cdd:PLN03150 481 SIPESLGQLTSLRILNLNGNSLSGRVPAALGGRLLHRASFNFTDNAGLCGIPGLRACGPHLSVGAKIGIAFGVSVAFLFL 560

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 571500055 528 ITGSVCWWKRRQNILRVQQITARAAPYAKARTQFSRDIQMTRHNNN------NNAENGPILLS 584
Cdd:PLN03150 561 VICAMCWWKRRQNILRAQRIAAREAPYAKARTHFSRDVQMTRHHRQnhgsarTAAENGPSLLS 623
 
Name Accession Description Interval E-value
PLN03150 PLN03150
hypothetical protein; Provisional
 10-584 0e+00

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 989.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055  10 LLLWMLFLC--FACTARAAQRGPFAMRISCGARQNVQTKPTTTLWYKDFGYTGGIPTNAKTSSYIAPPLKTLRYFPLSEG 87
Cdd:PLN03150   1 LRLWLLAASalLAVLASLASPEPFTMRISCGARVNVRTAPTNTLWYKDFAYTGGIPANATRPSFIAPPLKTLRYFPLSDG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055  88 PSNCYNINRVPKGHYSIRIFFGLVAQARATDEPLFDISIQGTQIYSLKSGWTTQDDQAFTEA------------------ 149
Cdd:PLN03150  81 PENCYNINRVPKGHYSVRVFFGLVAEPNFDSEPLFDVSVEGTQISSLKSGWSSHDEQVFAEAlvfltdgsasicfhstgh 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 150 ----------------------QWSQGIILRTVKRLSCGFGQSKYGVDYGADPRGGDRFWQHTETFGEDSDRPRSVETRI 207
Cdd:PLN03150 161 gdpailsieilqvddkaynfgpSWGQGVILRTAKRLSCGAGKSKFDEDYSGDHWGGDRFWNRMQTFGSGSDQAISTENVI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 208 KQASHPPNFYPETLYRSALVSTSSQPELTYTLDVDPNKNYSVWLHFAEIDNSVTAEGQRVFDIMINGDVAFKDVDIVKLS 287
Cdd:PLN03150 241 KKASNAPNFYPESLYQSALVSTDTQPDLSYTMDVDPNRNYSVWLHFAEIDNSITAEGKRVFDVLINGDTAFKDVDIVKMS 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 288 GDRYTALVLNTTVVVNGRTLTIALSPKDGSFAIINAIEIMEVIMAESKTLSDEVMALQKLKKALGLPPRFGWNGDPCVPQ 367
Cdd:PLN03150 321 GERYTALVLNKTVAVSGRTLTIVLQPKKGTHAIINAIEVFEIITAESKTLLEEVSALQTLKSSLGLPLRFGWNGDPCVPQ 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 368 QHPWTGADCRLDKSSSKWVIDGLGLDNQGLKGFLPNDISRLHNLQILNLSGNSIQGPIPSPLGTIASLQVLDLSYNFFNG 447
Cdd:PLN03150 401 QHPWSGADCQFDSTKGKWFIDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNG 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 448 SIPESLGQLTSLQRLNLNGNFLSGRVPATLGGRLLHGASFNFTDNAGLCGIPGLPTCGPHLSAGAKVGIGLGVSFTLLLL 527
Cdd:PLN03150 481 SIPESLGQLTSLRILNLNGNSLSGRVPAALGGRLLHRASFNFTDNAGLCGIPGLRACGPHLSVGAKIGIAFGVSVAFLFL 560

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 571500055 528 ITGSVCWWKRRQNILRVQQITARAAPYAKARTQFSRDIQMTRHNNN------NNAENGPILLS 584
Cdd:PLN03150 561 VICAMCWWKRRQNILRAQRIAAREAPYAKARTHFSRDVQMTRHHRQnhgsarTAAENGPSLLS 623
Malectin_like pfam12819
Malectin-like domain; Malectin is a membrane-anchored protein of the endoplasmic reticulum ...
 35-329 6.18e-49

Malectin-like domain; Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognizes and binds Glc2-N-glycan. The domain is found on a number of plant receptor kinases and is distantly related to malectin domains.


Pssm-ID: 432805 [Multi-domain]  Cd Length: 330  Bit Score: 172.86  E-value: 6.18e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055   35 ISCGARQNVQ-TKPTTTL-WYKDFGYT-GGIPTNAK---TSSYIAPPLKTLRYFPlsEGPSNCYNINRVPKGHYSIRIFF 108
Cdd:pfam12819   1 IDCGLPPNESyTDPTTGLtYVSDADFIdSGKSGNIQaelSTTFLSKPYLTLRSFP--EGKRNCYTLPVTKGTKYLIRATF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055  109 GLVAQARATDEPLFDISIQGTQ-----------------IYSLKSGWT------TQDDQAF------------TEAQWSq 153
Cdd:pfam12819  79 LYGNYDGLNSLPPFDLYLGPNKwttvdltnasngvykeiIHVPTSDTLdvclvkTGTGTPFisalelrplknsTYATTS- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055  154 GIILRTVKRLScgFGQSKYGVDYGADPrgGDRFWQhtETFGEDSDRPRSVETRIKQASHPPNFYPETLYRSALV--STSS 231
Cdd:pfam12819 158 GGSLVLYARLY--FGGSTTTIRYPDDV--YDRIWS--PFSLNPEWTQISTTLTVDNSSNNGYDPPSKVMQTAATptNASA 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055  232 QPELTYTLDvDPNKNYSVWLHFAEIDNSVTAEGQRVFDIMINGDVAFKDVDIVKLSGDryTALVLNTTVVV--NGRTLTI 309
Cdd:pfam12819 232 PLNFTWELD-DPTLQYYVYLHFAEIQSLGLNANTREFNIYLNGKTVYEPVSPKYLVGT--TVALYSPSPVTcsGGSCLLV 308

                         330       340
                  ....*....|....*....|..
gi 571500055  310 ALSPKDGSF--AIINAIEIMEV 329
Cdd:pfam12819 309 SLVKTPDSTlpPLLNAIEIYTV 330
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
390-479 1.04e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 1.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 390 LGLDNQGLKGfLPNDISRLHNLQILNLSGNSIQgPIPSPLGTIASLQVLDLSYNFFNgSIPESLGQLTSLQRLNLNGNFL 469
Cdd:COG4886  118 LDLSGNQLTD-LPEELANLTNLKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQLT-DLPEELGNLTNLKELDLSNNQI 194

                         90
                 ....*....|
gi 571500055 470 SgRVPATLGG 479
Cdd:COG4886  195 T-DLPEPLGN 203
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 411-467 2.30e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 2.30e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 571500055 411 LQILNLSGNSIQgpIPSPLGTIASLQVLDLSYNFFN--GSIPESLGQLTSLQRLNLNGN 467
Cdd:cd21340  122 LRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISdlEELLDLLSSWPSLRELDLTGN 178
3a0801s02tim23 TIGR00983
mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, ...
 352-449 1.18e-03

mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130056  Cd Length: 149  Bit Score: 39.82  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055  352 GLPPRFGWNGDPCVpqqhpWTGADCRLDKssskwVIDGLGLDNQGLKGFLPNDISRLHNLQILNLSGNsiQGPIpspLGT 431
Cdd:TIGR00983  23 GANPSRGWFEDLCF-----GTGTCYLTGL-----AIGALNGLRLGLKETQSMPWTKLRLNQILNMVTR--RGPF---WGN 87

                          90
                  ....*....|....*...
gi 571500055  432 iaSLQVLDLSYNFFNGSI 449
Cdd:TIGR00983  88 --TLGILALVYNGINSII 103
 
Name Accession Description Interval E-value
PLN03150 PLN03150
hypothetical protein; Provisional
 10-584 0e+00

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 989.70  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055  10 LLLWMLFLC--FACTARAAQRGPFAMRISCGARQNVQTKPTTTLWYKDFGYTGGIPTNAKTSSYIAPPLKTLRYFPLSEG 87
Cdd:PLN03150   1 LRLWLLAASalLAVLASLASPEPFTMRISCGARVNVRTAPTNTLWYKDFAYTGGIPANATRPSFIAPPLKTLRYFPLSDG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055  88 PSNCYNINRVPKGHYSIRIFFGLVAQARATDEPLFDISIQGTQIYSLKSGWTTQDDQAFTEA------------------ 149
Cdd:PLN03150  81 PENCYNINRVPKGHYSVRVFFGLVAEPNFDSEPLFDVSVEGTQISSLKSGWSSHDEQVFAEAlvfltdgsasicfhstgh 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 150 ----------------------QWSQGIILRTVKRLSCGFGQSKYGVDYGADPRGGDRFWQHTETFGEDSDRPRSVETRI 207
Cdd:PLN03150 161 gdpailsieilqvddkaynfgpSWGQGVILRTAKRLSCGAGKSKFDEDYSGDHWGGDRFWNRMQTFGSGSDQAISTENVI 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 208 KQASHPPNFYPETLYRSALVSTSSQPELTYTLDVDPNKNYSVWLHFAEIDNSVTAEGQRVFDIMINGDVAFKDVDIVKLS 287
Cdd:PLN03150 241 KKASNAPNFYPESLYQSALVSTDTQPDLSYTMDVDPNRNYSVWLHFAEIDNSITAEGKRVFDVLINGDTAFKDVDIVKMS 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 288 GDRYTALVLNTTVVVNGRTLTIALSPKDGSFAIINAIEIMEVIMAESKTLSDEVMALQKLKKALGLPPRFGWNGDPCVPQ 367
Cdd:PLN03150 321 GERYTALVLNKTVAVSGRTLTIVLQPKKGTHAIINAIEVFEIITAESKTLLEEVSALQTLKSSLGLPLRFGWNGDPCVPQ 400

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 368 QHPWTGADCRLDKSSSKWVIDGLGLDNQGLKGFLPNDISRLHNLQILNLSGNSIQGPIPSPLGTIASLQVLDLSYNFFNG 447
Cdd:PLN03150 401 QHPWSGADCQFDSTKGKWFIDGLGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNG 480

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 448 SIPESLGQLTSLQRLNLNGNFLSGRVPATLGGRLLHGASFNFTDNAGLCGIPGLPTCGPHLSAGAKVGIGLGVSFTLLLL 527
Cdd:PLN03150 481 SIPESLGQLTSLRILNLNGNSLSGRVPAALGGRLLHRASFNFTDNAGLCGIPGLRACGPHLSVGAKIGIAFGVSVAFLFL 560

                        570       580       590       600       610       620
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 571500055 528 ITGSVCWWKRRQNILRVQQITARAAPYAKARTQFSRDIQMTRHNNN------NNAENGPILLS 584
Cdd:PLN03150 561 VICAMCWWKRRQNILRAQRIAAREAPYAKARTHFSRDVQMTRHHRQnhgsarTAAENGPSLLS 623
Malectin_like pfam12819
Malectin-like domain; Malectin is a membrane-anchored protein of the endoplasmic reticulum ...
 35-329 6.18e-49

Malectin-like domain; Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognizes and binds Glc2-N-glycan. The domain is found on a number of plant receptor kinases and is distantly related to malectin domains.


Pssm-ID: 432805 [Multi-domain]  Cd Length: 330  Bit Score: 172.86  E-value: 6.18e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055   35 ISCGARQNVQ-TKPTTTL-WYKDFGYT-GGIPTNAK---TSSYIAPPLKTLRYFPlsEGPSNCYNINRVPKGHYSIRIFF 108
Cdd:pfam12819   1 IDCGLPPNESyTDPTTGLtYVSDADFIdSGKSGNIQaelSTTFLSKPYLTLRSFP--EGKRNCYTLPVTKGTKYLIRATF 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055  109 GLVAQARATDEPLFDISIQGTQ-----------------IYSLKSGWT------TQDDQAF------------TEAQWSq 153
Cdd:pfam12819  79 LYGNYDGLNSLPPFDLYLGPNKwttvdltnasngvykeiIHVPTSDTLdvclvkTGTGTPFisalelrplknsTYATTS- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055  154 GIILRTVKRLScgFGQSKYGVDYGADPrgGDRFWQhtETFGEDSDRPRSVETRIKQASHPPNFYPETLYRSALV--STSS 231
Cdd:pfam12819 158 GGSLVLYARLY--FGGSTTTIRYPDDV--YDRIWS--PFSLNPEWTQISTTLTVDNSSNNGYDPPSKVMQTAATptNASA 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055  232 QPELTYTLDvDPNKNYSVWLHFAEIDNSVTAEGQRVFDIMINGDVAFKDVDIVKLSGDryTALVLNTTVVV--NGRTLTI 309
Cdd:pfam12819 232 PLNFTWELD-DPTLQYYVYLHFAEIQSLGLNANTREFNIYLNGKTVYEPVSPKYLVGT--TVALYSPSPVTcsGGSCLLV 308

                         330       340
                  ....*....|....*....|..
gi 571500055  310 ALSPKDGSF--AIINAIEIMEV 329
Cdd:pfam12819 309 SLVKTPDSTlpPLLNAIEIYTV 330
Malectin pfam11721
Malectin domain; Malectin is a membrane-anchored protein of the endoplasmic reticulum that ...
 162-324 2.89e-20

Malectin domain; Malectin is a membrane-anchored protein of the endoplasmic reticulum that recognizes and binds Glc2-N-glycan. It carries a signal peptide from residues 1-26, a C-terminal transmembrane helix from residues 255-274, and a highly conserved central part of approximately 190 residues followed by an acidic, glutamate-rich region. Carbohydrate-binding is mediated by the four aromatic residues, Y67, Y89, Y116, and F117 and the aspartate at D186. NMR-based ligand-screening studies has shown binding of the protein to maltose and related oligosaccharides, on the basis of which the protein has been designated "malectin", and its endogenous ligand is found to be Glc2-high-mannose N-glycan.


Pssm-ID: 432024 [Multi-domain]  Cd Length: 165  Bit Score: 88.20  E-value: 2.89e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055  162 RLSCGFGQ--SKYGVDYGADprggdRFWQHTETFGEDSDRPRSVETRIKQASHPpnfypeTLYRSALVSTSSqpeLTYTL 239
Cdd:pfam11721   4 AINCGGPEavDSDGILYEAD-----RHFDGGSVADYYVSQQSTRSLSIKNTDDQ------ELYQTERYGPSS---FSYDI 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055  240 DVDPNKNYSVWLHFAEIDNSVTAEGQRVFDIMINGDVAFKDVDIVKLSGDRYTALVLNTTVVVNGRTLTIALS------- 312
Cdd:pfam11721  70 PILENGNYTLILYFAEIYFGETGPGRRVFDIYVNGKLVLKDFDIVAEAGGSGTAHDEYIPVTVTDGKLEICFSwagkgtl 149

                         170
                  ....*....|....*.
gi 571500055  313 --PKDGSF--AIINAI 324
Cdd:pfam11721 150 liPFRGVYdnPKISAI 165
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
390-479 1.04e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 1.04e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 390 LGLDNQGLKGfLPNDISRLHNLQILNLSGNSIQgPIPSPLGTIASLQVLDLSYNFFNgSIPESLGQLTSLQRLNLNGNFL 469
Cdd:COG4886  118 LDLSGNQLTD-LPEELANLTNLKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQLT-DLPEELGNLTNLKELDLSNNQI 194

                         90
                 ....*....|
gi 571500055 470 SgRVPATLGG 479
Cdd:COG4886  195 T-DLPEPLGN 203
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
401-501 2.64e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.13  E-value: 2.64e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 401 LPNDISRLHNLQILNLSGNSIQGpIPSPLGTIASLQVLDLSYNFFNgSIPESLGQLTSLQRLNLNGNFLSgRVPATLGG- 479
Cdd:COG4886  151 LPEPLGNLTNLKSLDLSNNQLTD-LPEELGNLTNLKELDLSNNQIT-DLPEPLGNLTNLEELDLSGNQLT-DLPEPLANl 227

                         90       100
                 ....*....|....*....|....*.
gi 571500055 480 ---RLLHgASFN-FTDNAGLCGIPGL 501
Cdd:COG4886  228 tnlETLD-LSNNqLTDLPELGNLTNL 252
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 390-479 8.04e-15

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.97  E-value: 8.04e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 390 LGLDNQGLKGFLPNDISRLHNLQILNLSGNSIQGPIPSPLGTIASLQVLDLSYNFFNGSIPESLGQLTSLQRLNLNGNFL 469
Cdd:PLN00113 145 LDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNL 224

                         90
                 ....*....|
gi 571500055 470 SGRVPATLGG 479
Cdd:PLN00113 225 SGEIPYEIGG 234
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 382-501 1.47e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.20  E-value: 1.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 382 SSKWVIdgLGLDNqgLKGFLPNDISRLHNLQILNLSGNSIQGPIPSPLGTIASLQVLDLSYNFFNGSIPESLGQLTSLQR 461
Cdd:PLN00113 213 SLKWIY--LGYNN--LSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLIS 288

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 571500055 462 LNLNGNFLSGRVPATLGG----RLLHGASFNFTDN--AGLCGIPGL 501
Cdd:PLN00113 289 LDLSDNSLSGEIPELVIQlqnlEILHLFSNNFTGKipVALTSLPRL 334
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 390-478 5.88e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 75.27  E-value: 5.88e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 390 LGLDNQGLKGFLPNdiSRLHNLQILNLSGNSIQGPIPSPLGTIASLQVLDLSYNFFNGSIPESLGQLTSLQRLNLNGNFL 469
Cdd:PLN00113 123 LNLSNNNFTGSIPR--GSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL 200


                 ....*....
gi 571500055 470 SGRVPATLG 478
Cdd:PLN00113 201 VGQIPRELG 209
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 390-478 1.13e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 74.11  E-value: 1.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 390 LGLDNQGLKGFLPNDISRLHNLQILNLSGNSIQGPIPSPLGTIASLQVLDLSYNFFNGSIPESLGQLTSLQRLNLNGNFL 469
Cdd:PLN00113 169 LDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNL 248


                 ....*....
gi 571500055 470 SGRVPATLG 478
Cdd:PLN00113 249 TGPIPSSLG 257
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 338-478 1.15e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 74.11  E-value: 1.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 338 SDEVMALQKLKKALGLPPRF--GWN--GDPCVpqqhpWTGADCrldKSSSKwvIDGLGLDNQGLKGFLPNDISRLHNLQI 413
Cdd:PLN00113  28 AEELELLLSFKSSINDPLKYlsNWNssADVCL-----WQGITC---NNSSR--VVSIDLSGKNISGKISSAIFRLPYIQT 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 414 LNLSGNSIQGPIPS-----------------------PLGTIASLQVLDLSYNFFNGSIPESLGQLTSLQRLNLNGNFLS 470
Cdd:PLN00113  98 INLSNNQLSGPIPDdifttssslrylnlsnnnftgsiPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLV 177


                 ....*...
gi 571500055 471 GRVPATLG 478
Cdd:PLN00113 178 GKIPNSLT 185
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 387-504 1.30e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 74.11  E-value: 1.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 387 IDGLGLDNQGLKGFLPNDISRLHNLQILNLSGNSIQGPIPSPLGTIASLQVLDLSYNFFNGSIPESLGQLTSLQRLNLNG 466
Cdd:PLN00113 477 LENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQ 556

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 571500055 467 NFLSGRVPATLGG-----------RLLHGA--------SFNFTDNAG---LCG---IPGLPTC 504
Cdd:PLN00113 557 NQLSGEIPKNLGNveslvqvnishNHLHGSlpstgaflAINASAVAGnidLCGgdtTSGLPPC 619
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
390-471 1.42e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.04  E-value: 1.42e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 390 LGLDNQGLKgFLPNDISRLHNLQILNLSGNSIQgPIPSPLGTIASLQVLDLSYNFFNgSIPEsLGQLTSLQRLNLNGNFL 469
Cdd:COG4886  187 LDLSNNQIT-DLPEPLGNLTNLEELDLSGNQLT-DLPEPLANLTNLETLDLSNNQLT-DLPE-LGNLTNLEELDLSNNQL 262


                 ..
gi 571500055 470 SG 471
Cdd:COG4886  263 TD 264
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
402-479 1.58e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 1.58e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 571500055 402 PNDISRLHNLQILNLSGNSIQGpIPSPLGTIASLQVLDLSYNFFNgSIPESLGQLTSLQRLNLNGNFLSGrVPATLGG 479
Cdd:COG4886  106 NEELSNLTNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLT-DLPEPLGNLTNLKSLDLSNNQLTD-LPEELGN 180
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 390-501 2.83e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.96  E-value: 2.83e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 390 LGLDNQGLKGFLPNDISRLHNLQILNLSGNSIQGPIPSPLGTIASLQVLDLSYNFFNGSIPESLGQLTSLQRLNLNGNFL 469
Cdd:PLN00113 193 LTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKL 272

                         90       100       110
                 ....*....|....*....|....*....|..
gi 571500055 470 SGRVPATLGGrLLHGASFNFTDNAGLCGIPGL 501
Cdd:PLN00113 273 SGPIPPSIFS-LQKLISLDLSDNSLSGEIPEL 303
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 390-477 1.52e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.65  E-value: 1.52e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 390 LGLDNQGLKGFLPNDISRLHNLQILNLSGNSIQGPIPSPLGTIASLQVLDLSYNFFNGSIPESLGQLTSLQRLNLNGNFL 469
Cdd:PLN00113 289 LDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNL 368


                 ....*...
gi 571500055 470 SGRVPATL 477
Cdd:PLN00113 369 TGEIPEGL 376
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 397-480 4.87e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 65.64  E-value: 4.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 397 LKGFLPNDISRLHNLQILNLSGNSIQGPIPSPLGTIASLQVLDLSYNFFNGSIPESLGQLTSLQRLNLNGNFLSGRVPAT 476
Cdd:PLN00113 272 LSGPIPPSIFSLQKLISLDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKN 351


                 ....
gi 571500055 477 LGGR 480
Cdd:PLN00113 352 LGKH 355
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 392-478 5.41e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.56  E-value: 5.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 392 LDNQGLKGFLPNDISRLHNLQILNLSGNSIQGPIPSPLGTIASLQVLDLSYNFFNGSIPESLGQlTSLQRLNLNGNFLSG 471
Cdd:PLN00113 411 LQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSG 489


                 ....*..
gi 571500055 472 RVPATLG 478
Cdd:PLN00113 490 AVPRKLG 496
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 390-478 6.16e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.17  E-value: 6.16e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 390 LGLDNQGLKGFLPNDISRLHNLQILNLSGNSIQGPIPSPLGTIASLQVLDLSYNFFNGSIPESLGQLTSLQRLNLNGNFL 469
Cdd:PLN00113 313 LHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSL 392


                 ....*....
gi 571500055 470 SGRVPATLG 478
Cdd:PLN00113 393 EGEIPKSLG 401
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 381-476 6.43e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.17  E-value: 6.43e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 381 SSSKW---VIDGLGLDNQGLKGFLPnDISRLHNLQILNLSGNSIQGPIPSPLGTIASLQVLDLSYNFFNGSIPESLGQLT 457
Cdd:PLN00113 445 NSRKWdmpSLQMLSLARNKFFGGLP-DSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCK 523

                         90
                 ....*....|....*....
gi 571500055 458 SLQRLNLNGNFLSGRVPAT 476
Cdd:PLN00113 524 KLVSLDLSHNQLSGQIPAS 542
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 390-477 1.18e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 61.40  E-value: 1.18e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 390 LGLDNQGLKGFLPNDISRLHNLQILNLSGNSIQGPIPSPLGTiASLQVLDLSYNFFNGSIPESLGQLTSLQRLNLNGNFL 469
Cdd:PLN00113 433 LDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKL 511


                 ....*...
gi 571500055 470 SGRVPATL 477
Cdd:PLN00113 512 SGEIPDEL 519
LRR_8 pfam13855
Leucine rich repeat;
410-467 3.77e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 3.77e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 571500055  410 NLQILNLSGNSIQGPIPSPLGTIASLQVLDLSYNFFNGSIPESLGQLTSLQRLNLNGN 467
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 397-474 4.52e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.48  E-value: 4.52e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 571500055 397 LKGFLPNDISRLHNLQILNLSGNSIQGPIPSPLGTIASLQVLDLSYNFFNGSIPESLGQLTSLQRLNLNGNFLSGRVP 474
Cdd:PLN00113 344 FSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELP 421
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 411-467 2.30e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.71  E-value: 2.30e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 571500055 411 LQILNLSGNSIQgpIPSPLGTIASLQVLDLSYNFFN--GSIPESLGQLTSLQRLNLNGN 467
Cdd:cd21340  122 LRVLNISGNNID--SLEPLAPLRNLEQLDASNNQISdlEELLDLLSSWPSLRELDLTGN 178
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
390-508 1.64e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.62  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 390 LGLDNQGLKGfLPNdISRLHNLQILNLSGNSIQGpIPsPLGTIASLQVLDLSYNFFNGSIPESLGQLTSLQRLNLNGNFL 469
Cdd:COG4886  233 LDLSNNQLTD-LPE-LGNLTNLEELDLSNNQLTD-LP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLL 308

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 571500055 470 SGRVPATLGGRLLHGASFNFTDNAGLCGIPGLPTCGPHL 508
Cdd:COG4886  309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 390-473 3.53e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 3.53e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 390 LGLDNQGLKGFLPNDISRLHNLQILNLSGNSIQGPIPSPLGTIASLQVLDLSYNFFNGSIPESLGQLTSLQRLNLNGNFL 469
Cdd:PLN00113 361 LDLSTNNLTGEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL 440


                 ....
gi 571500055 470 SGRV 473
Cdd:PLN00113 441 QGRI 444
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 397-482 1.37e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 1.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 397 LKGFLPNDISRLHNLQILNLSGNSIQGPIPSPLGTIASLQVLDLSYNFFNGSIPESLGQLTSLQRLNLNGNFLSGRVPAT 476
Cdd:PLN00113 392 LEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDS 471


                 ....*.
gi 571500055 477 LGGRLL 482
Cdd:PLN00113 472 FGSKRL 477
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 403-470 6.40e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 6.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 403 NDISR------LHNLQILNLSGNSI--------------------QGPIPSPL----GTIA----SLQVLDLSYNffNGS 448
Cdd:cd21340   56 NQIEKienlenLVNLKKLYLGGNRIsvveglenltnleelhienqRLPPGEKLtfdpRSLAalsnSLRVLNISGN--NID 133

                         90       100
                 ....*....|....*....|..
gi 571500055 449 IPESLGQLTSLQRLNLNGNFLS 470
Cdd:cd21340  134 SLEPLAPLRNLEQLDASNNQIS 155
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 410-451 9.12e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 9.12e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 571500055  410 NLQILNLSGNSIQGpIPsPLGTIASLQVLDLSYNFFNGSIPE 451
Cdd:pfam12799   2 NLEVLDLSNNQITD-IP-PLAKLPNLETLDLSGNNKITDLSD 41
3a0801s02tim23 TIGR00983
mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, ...
 352-449 1.18e-03

mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130056  Cd Length: 149  Bit Score: 39.82  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055  352 GLPPRFGWNGDPCVpqqhpWTGADCRLDKssskwVIDGLGLDNQGLKGFLPNDISRLHNLQILNLSGNsiQGPIpspLGT 431
Cdd:TIGR00983  23 GANPSRGWFEDLCF-----GTGTCYLTGL-----AIGALNGLRLGLKETQSMPWTKLRLNQILNMVTR--RGPF---WGN 87

                          90
                  ....*....|....*...
gi 571500055  432 iaSLQVLDLSYNFFNGSI 449
Cdd:TIGR00983  88 --TLGILALVYNGINSII 103
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 411-486 4.00e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 4.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 571500055 411 LQILNLSGNSIQGP-IPS---PLGTIASLQVLDLSYNFFN----GSIPESLGQLTSLQRLNLNGNFLSGRVPATLGGRLL 482
Cdd:cd00116  167 LKELNLANNGIGDAgIRAlaeGLKANCNLEVLDLNNNGLTdegaSALAETLASLKSLEVLNLGDNNLTDAGAAALASALL 246


                 ....
gi 571500055 483 HGAS 486
Cdd:cd00116  247 SPNI 250
LRR_8 pfam13855
Leucine rich repeat;
390-443 4.61e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 4.61e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 571500055  390 LGLDNQGLKGFLPNDISRLHNLQILNLSGNSIQGPIPSPLGTIASLQVLDLSYN 443
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 434-467 9.62e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 9.62e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 571500055  434 SLQVLDLSYNFFNgSIPeSLGQLTSLQRLNLNGN 467
Cdd:pfam12799   2 NLEVLDLSNNQIT-DIP-PLAKLPNLETLDLSGN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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