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Conserved domains on  [gi|568947893|ref|XP_006540959|]
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palmitoyltransferase ZDHHC13 isoform X1 [Mus musculus]

Protein Classification

ankyrin repeat domain-containing DHHC palmitoyltransferase family protein( domain architecture ID 12790884)

DHHC family palmitoyltransferase may catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes; contains N-terminal ankyrin repeats;

EC:  2.3.1.-
Gene Ontology:  GO:0043543|GO:0016747
PubMed:  21388813

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DHHC pfam01529
DHHC palmitoyltransferase; This entry refers to the DHHC domain, found in DHHC proteins which ...
 293-427 9.27e-32

DHHC palmitoyltransferase; This entry refers to the DHHC domain, found in DHHC proteins which are palmitoyltransferases. Palmitoylation or, more specifically S-acylation, plays important roles in the regulation of protein localization, stability, and activity. It is a post-translational protein modification that involves the attachment of palmitic acid to Cys residues through a thioester linkage. Protein acyltransferases (PATs), also known as palmitoyltransferases, catalyze this reaction by transferring the palmitoyl group from palmitoyl-CoA to the thiol group of Cys residues. They are characterized by the presence of a 50-residue-long domain called the DHHC domain, which in most but not all cases is also cysteine-rich and gets its name from a highly conserved DHHC signature tetrapeptide (Asp-His-His-Cys). The Cys residue within the DHHC domain forms a stable acyl intermediate and transfers the acyl chain to the Cys residues of a target protein. Some proteins containing a DHHC domain include Drosophila DNZ1 protein, Mouse Abl-philin 2 (Aph2) protein, Mammalian ZDHHC9, Yeast ankyrin repeat-containing protein AKR1, Yeast Erf2 protein, and Arabidopsis thaliana tip growth defective 1.


:

Pssm-ID: 396215  Cd Length: 132  Bit Score: 118.62  E-value: 9.27e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893  293 DFRTFCTSCLIRKPLRSLHCHVCNSCVARFDQHCFWTGRCIGFGNHHHYIFFLLSLSMVCDWIIYGSFVYWSNHCATTFK 372
Cdd:pfam01529   3 DELKYCSTCNIYKPPRSKHCRVCNRCVLRFDHHCPWLNNCIGKRNHKYFILFLLYLTLYLILYLVLSLYYLVKLIESSTL 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568947893  373 EDGLWTYLNQivacspWVLYIFMLAAFHFSWSTFLLINQLFQIaFLGLTSHERIS 427
Cdd:pfam01529  83 FFFLILFLFS------ISIILLILSLFFLLFLGILLFFHLYLI-SRNLTTYEFMK 130
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-159 5.96e-28

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 112.74  E-value: 5.96e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893   1 MVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAYKviG-PEPTGFLLKFNPSL 79
Cdd:COG0666  102 IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN--GnLEIVKLLLEAGADV 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893  80 SVVDKtHQNTPLHWAVAAGNVSAVDKLLEAGSSLDIRNAKGETPLDMALQSKNQLISHMLRTEAKMRANKQFRLWRWLHK 159
Cdd:COG0666  180 NARDN-DGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258
 
Name Accession Description Interval E-value
DHHC pfam01529
DHHC palmitoyltransferase; This entry refers to the DHHC domain, found in DHHC proteins which ...
 293-427 9.27e-32

DHHC palmitoyltransferase; This entry refers to the DHHC domain, found in DHHC proteins which are palmitoyltransferases. Palmitoylation or, more specifically S-acylation, plays important roles in the regulation of protein localization, stability, and activity. It is a post-translational protein modification that involves the attachment of palmitic acid to Cys residues through a thioester linkage. Protein acyltransferases (PATs), also known as palmitoyltransferases, catalyze this reaction by transferring the palmitoyl group from palmitoyl-CoA to the thiol group of Cys residues. They are characterized by the presence of a 50-residue-long domain called the DHHC domain, which in most but not all cases is also cysteine-rich and gets its name from a highly conserved DHHC signature tetrapeptide (Asp-His-His-Cys). The Cys residue within the DHHC domain forms a stable acyl intermediate and transfers the acyl chain to the Cys residues of a target protein. Some proteins containing a DHHC domain include Drosophila DNZ1 protein, Mouse Abl-philin 2 (Aph2) protein, Mammalian ZDHHC9, Yeast ankyrin repeat-containing protein AKR1, Yeast Erf2 protein, and Arabidopsis thaliana tip growth defective 1.


Pssm-ID: 396215  Cd Length: 132  Bit Score: 118.62  E-value: 9.27e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893  293 DFRTFCTSCLIRKPLRSLHCHVCNSCVARFDQHCFWTGRCIGFGNHHHYIFFLLSLSMVCDWIIYGSFVYWSNHCATTFK 372
Cdd:pfam01529   3 DELKYCSTCNIYKPPRSKHCRVCNRCVLRFDHHCPWLNNCIGKRNHKYFILFLLYLTLYLILYLVLSLYYLVKLIESSTL 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568947893  373 EDGLWTYLNQivacspWVLYIFMLAAFHFSWSTFLLINQLFQIaFLGLTSHERIS 427
Cdd:pfam01529  83 FFFLILFLFS------ISIILLILSLFFLLFLGILLFFHLYLI-SRNLTTYEFMK 130
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-159 5.96e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 112.74  E-value: 5.96e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893   1 MVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAYKviG-PEPTGFLLKFNPSL 79
Cdd:COG0666  102 IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN--GnLEIVKLLLEAGADV 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893  80 SVVDKtHQNTPLHWAVAAGNVSAVDKLLEAGSSLDIRNAKGETPLDMALQSKNQLISHMLRTEAKMRANKQFRLWRWLHK 159
Cdd:COG0666  180 NARDN-DGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258
COG5273 COG5273
Uncharacterized protein containing DHHC-type Zn finger [General function prediction only];
211-458 5.45e-26

Uncharacterized protein containing DHHC-type Zn finger [General function prediction only];


Pssm-ID: 227598 [Multi-domain]  Cd Length: 309  Bit Score: 107.91  E-value: 5.45e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893 211 YKNLVYLPTVFLLSSIFWIFMTwFILFFPDTAGSPLYFAFIFSIMAFLYFFYKTwaTDPGF--TKASEEERKVNIVTLAE 288
Cdd:COG5273   26 YAYKMFIGLFLLSRIVVYTLLV-IVKSLSLVVLFIILFIVILVLASFSYLLLLV--SDPGYlgENITLSGYRETISRLLD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893 289 TGSLDFRTFCTSCLIRKPLRSLHCHVCNSCVARFDQHCFWTGRCIGFGNHHHYIFFLLslsmvcdWIIYGSFVYWSNHCA 368
Cdd:COG5273  103 DGKFGTENFCSTCNIYKPPRSHHCSICNRCVLKFDHHCPWINNCVGFRNYRFFYQFLL-------YTILVALVVLLSTAY 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893 369 TTFKEDGLWTYLNQIV-------ACSPWVLYIFMLAAFHFswSTFLLINQLFQIAFL----GLTSHERISLLKQS-RHMK 436
Cdd:COG5273  176 YIAGIFSIRHDTSLAIcflifgcSLLGVVFFIITTLLLLF--LIYLILNNLTTIEFIqisrGGSTLEFFPLCRESnLPFT 253

                        250       260
                 ....*....|....*....|....
gi 568947893 437 QTLSLRKT--PYNLGFTQNLADFF 458
Cdd:COG5273  254 NIFDSSEGalPLDLGIGQNLSTIK 277
Ank_2 pfam12796
Ankyrin repeats (3 copies);
23-117 4.62e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 64.75  E-value: 4.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893   23 IHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAYKvigpeptG------FLLKFNPslsVVDKTHQNTPLHWAVA 96
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKN-------GhleivkLLLEHAD---VNLKDNGRTALHYAAR 70

                          90       100
                  ....*....|....*....|.
gi 568947893   97 AGNVSAVDKLLEAGSSLDIRN 117
Cdd:pfam12796  71 SGHLEIVKLLLEKGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1-141 4.73e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 65.08  E-value: 4.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893   1 MVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNgqtplMLSAYKVIGPEPTGFLLKFNPSLS 80
Cdd:PHA02876 193 MVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDLS-----LLKAIRNEDLETSLLLYDAGFSVN 267

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568947893  81 VVDkTHQNTPLHWAVAAGNVSA-VDKLLEAGSSLDIRNAKGETPLdmALQSKNQLISHMLRT 141
Cdd:PHA02876 268 SID-DCKNTPLHHASQAPSLSRlVPKLLERGADVNAKNIKGETPL--YLMAKNGYDTENIRT 326
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 86-115 1.93e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.64  E-value: 1.93e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 568947893    86 HQNTPLHWAVAAGNVSAVDKLLEAGSSLDI 115
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
DHHC pfam01529
DHHC palmitoyltransferase; This entry refers to the DHHC domain, found in DHHC proteins which ...
 293-427 9.27e-32

DHHC palmitoyltransferase; This entry refers to the DHHC domain, found in DHHC proteins which are palmitoyltransferases. Palmitoylation or, more specifically S-acylation, plays important roles in the regulation of protein localization, stability, and activity. It is a post-translational protein modification that involves the attachment of palmitic acid to Cys residues through a thioester linkage. Protein acyltransferases (PATs), also known as palmitoyltransferases, catalyze this reaction by transferring the palmitoyl group from palmitoyl-CoA to the thiol group of Cys residues. They are characterized by the presence of a 50-residue-long domain called the DHHC domain, which in most but not all cases is also cysteine-rich and gets its name from a highly conserved DHHC signature tetrapeptide (Asp-His-His-Cys). The Cys residue within the DHHC domain forms a stable acyl intermediate and transfers the acyl chain to the Cys residues of a target protein. Some proteins containing a DHHC domain include Drosophila DNZ1 protein, Mouse Abl-philin 2 (Aph2) protein, Mammalian ZDHHC9, Yeast ankyrin repeat-containing protein AKR1, Yeast Erf2 protein, and Arabidopsis thaliana tip growth defective 1.


Pssm-ID: 396215  Cd Length: 132  Bit Score: 118.62  E-value: 9.27e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893  293 DFRTFCTSCLIRKPLRSLHCHVCNSCVARFDQHCFWTGRCIGFGNHHHYIFFLLSLSMVCDWIIYGSFVYWSNHCATTFK 372
Cdd:pfam01529   3 DELKYCSTCNIYKPPRSKHCRVCNRCVLRFDHHCPWLNNCIGKRNHKYFILFLLYLTLYLILYLVLSLYYLVKLIESSTL 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 568947893  373 EDGLWTYLNQivacspWVLYIFMLAAFHFSWSTFLLINQLFQIaFLGLTSHERIS 427
Cdd:pfam01529  83 FFFLILFLFS------ISIILLILSLFFLLFLGILLFFHLYLI-SRNLTTYEFMK 130
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-159 5.96e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 112.74  E-value: 5.96e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893   1 MVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAYKviG-PEPTGFLLKFNPSL 79
Cdd:COG0666  102 IVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAAN--GnLEIVKLLLEAGADV 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893  80 SVVDKtHQNTPLHWAVAAGNVSAVDKLLEAGSSLDIRNAKGETPLDMALQSKNQLISHMLRTEAKMRANKQFRLWRWLHK 159
Cdd:COG0666  180 NARDN-DGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLL 258
COG5273 COG5273
Uncharacterized protein containing DHHC-type Zn finger [General function prediction only];
211-458 5.45e-26

Uncharacterized protein containing DHHC-type Zn finger [General function prediction only];


Pssm-ID: 227598 [Multi-domain]  Cd Length: 309  Bit Score: 107.91  E-value: 5.45e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893 211 YKNLVYLPTVFLLSSIFWIFMTwFILFFPDTAGSPLYFAFIFSIMAFLYFFYKTwaTDPGF--TKASEEERKVNIVTLAE 288
Cdd:COG5273   26 YAYKMFIGLFLLSRIVVYTLLV-IVKSLSLVVLFIILFIVILVLASFSYLLLLV--SDPGYlgENITLSGYRETISRLLD 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893 289 TGSLDFRTFCTSCLIRKPLRSLHCHVCNSCVARFDQHCFWTGRCIGFGNHHHYIFFLLslsmvcdWIIYGSFVYWSNHCA 368
Cdd:COG5273  103 DGKFGTENFCSTCNIYKPPRSHHCSICNRCVLKFDHHCPWINNCVGFRNYRFFYQFLL-------YTILVALVVLLSTAY 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893 369 TTFKEDGLWTYLNQIV-------ACSPWVLYIFMLAAFHFswSTFLLINQLFQIAFL----GLTSHERISLLKQS-RHMK 436
Cdd:COG5273  176 YIAGIFSIRHDTSLAIcflifgcSLLGVVFFIITTLLLLF--LIYLILNNLTTIEFIqisrGGSTLEFFPLCRESnLPFT 253

                        250       260
                 ....*....|....*....|....
gi 568947893 437 QTLSLRKT--PYNLGFTQNLADFF 458
Cdd:COG5273  254 NIFDSSEGalPLDLGIGQNLSTIK 277
Ank_2 pfam12796
Ankyrin repeats (3 copies);
23-117 4.62e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 64.75  E-value: 4.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893   23 IHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAYKvigpeptG------FLLKFNPslsVVDKTHQNTPLHWAVA 96
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKN-------GhleivkLLLEHAD---VNLKDNGRTALHYAAR 70

                          90       100
                  ....*....|....*....|.
gi 568947893   97 AGNVSAVDKLLEAGSSLDIRN 117
Cdd:pfam12796  71 SGHLEIVKLLLEKGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1-141 4.73e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 65.08  E-value: 4.73e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893   1 MVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNgqtplMLSAYKVIGPEPTGFLLKFNPSLS 80
Cdd:PHA02876 193 MVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNDLS-----LLKAIRNEDLETSLLLYDAGFSVN 267

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568947893  81 VVDkTHQNTPLHWAVAAGNVSA-VDKLLEAGSSLDIRNAKGETPLdmALQSKNQLISHMLRT 141
Cdd:PHA02876 268 SID-DCKNTPLHHASQAPSLSRlVPKLLERGADVNAKNIKGETPL--YLMAKNGYDTENIRT 326
PHA03095 PHA03095
ankyrin-like protein; Provisional
 2-130 9.76e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 63.89  E-value: 9.76e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893   2 VILLLQHGADPTLIDGEGFSSIHLAVLFQH-MPIIAYLISKGQSVNMTDVNGQTPlmLSAY---KVIGPEPTGFLLKFNP 77
Cdd:PHA03095  66 VRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTP--LHVYlsgFNINPKVIRLLLRKGA 143

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568947893  78 SLSVVDKtHQNTPLHWAVAAGNVSA--VDKLLEAGSSLDIRNAKGETPLDMALQS 130
Cdd:PHA03095 144 DVNALDL-YGMTPLAVLLKSRNANVelLRLLIDAGADVYAVDDRFRSLLHHHLQS 197
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1-132 1.10e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 63.51  E-value: 1.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893   1 MVILLLQHGADPTLIDGEGFSSIHlavlfQHM-------PIIAYLISKGQSVNMTDVNGQTPLMLSAYK------VIGPe 67
Cdd:PHA03095 169 LLRLLIDAGADVYAVDDRFRSLLH-----HHLqsfkpraRIVRELIRAGCDPAATDMLGNTPLHSMATGssckrsLVLP- 242

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568947893  68 ptgFLLKfNPSLSVVDKTHQnTPLHWAVAAGNVSAVDKLLEAGSSLDIRNAKGETPLDMALQSKN 132
Cdd:PHA03095 243 ---LLIA-GISINARNRYGQ-TPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNN 302
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1-133 2.53e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 62.35  E-value: 2.53e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893   1 MVILLLQHGADPTLIDGEGFS--SIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPL----------------MLSAyk 62
Cdd:PHA03095  99 VIKLLIKAGADVNAKDKVGRTplHVYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLavllksrnanvellrlLIDA-- 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893  63 viGPEPTG-----------FLLKFNPSLSVVDK------------THQNTPLHWAVAAGNV--SAVDKLLEAGSSLDIRN 117
Cdd:PHA03095 177 --GADVYAvddrfrsllhhHLQSFKPRARIVREliragcdpaatdMLGNTPLHSMATGSSCkrSLVLPLLIAGISINARN 254

                        170
                 ....*....|....*.
gi 568947893 118 AKGETPLDMALQSKNQ 133
Cdd:PHA03095 255 RYGQTPLHYAAVFNNP 270
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1-139 5.80e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 61.22  E-value: 5.80e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893   1 MVILLLQHGADPTLIDGEGFSSIHLAVLFQH--MPIIAYLISKGQSVN-MTDVNgqtplmlsaykvigpeptgFLLKFNP 77
Cdd:PHA03100 123 IVEYLLDNGANVNIKNSDGENLLHLYLESNKidLKILKLLIDKGVDINaKNRVN-------------------YLLSYGV 183

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568947893  78 SLSVVDKtHQNTPLHWAVAAGNVSAVDKLLEAGSSLDIRNAKGETPLDMALQSKNQLISHML 139
Cdd:PHA03100 184 PINIKDV-YGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-132 8.57e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.89  E-value: 8.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893   1 MVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAYKVIGPEPTGFLLKFNPSLS 80
Cdd:COG0666    2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568947893  81 VVDKtHQNTPLHWAVAAGNVSAVDKLLEAGSSLDIRNAKGETPLDMALQSKN 132
Cdd:COG0666   82 AKDD-GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGN 132
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 2-134 1.60e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 56.51  E-value: 1.60e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893   2 VILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSA----YKVIG------------ 65
Cdd:PHA02874 140 IKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAeygdYACIKllidhgnhimnk 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893  66 ------PEPTGF--------LLKFNPSLSVVDkTHQNTPLHWAVA-AGNVSAVDKLLEAGSSLDIRNAKGETPLDMALQS 130
Cdd:PHA02874 220 ckngftPLHNAIihnrsaieLLINNASINDQD-IDGSTPLHHAINpPCDIDIIDILLYHKADISIKDNKGENPIDTAFKY 298


                 ....
gi 568947893 131 KNQL 134
Cdd:PHA02874 299 INKD 302
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1-139 1.76e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 56.54  E-value: 1.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893   1 MVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNmtDV---NGQTPLMLsAYKVIGPEPTGFLLKF-- 75
Cdd:PHA02875  50 AIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFAD--DVfykDGMTPLHL-ATILKKLDIMKLLIARga 126

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568947893  76 NPSLSVVDKThqnTPLHWAVAAGNVSAVDKLLEAGSSLDIRNAKGETPLDMALQSKNQLISHML 139
Cdd:PHA02875 127 DPDIPNTDKF---SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKML 187
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 26-148 2.38e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 56.15  E-value: 2.38e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893  26 AVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLsAYKVIGPEPTGFLLKFNpSLSVVDKTHQNTPLHWAVAAGNVSAVDK 105
Cdd:PHA02875   9 AILFGELDIARRLLDIGINPNFEIYDGISPIKL-AMKFRDSEAIKLLMKHG-AIPDVKYPDIESELHDAVEEGDVKAVEE 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 568947893 106 LLEAGSSL-DIRNAKGETPLDMALQSKNqliSHMLRTEAKMRAN 148
Cdd:PHA02875  87 LLDLGKFAdDVFYKDGMTPLHLATILKK---LDIMKLLIARGAD 127
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 4-138 6.55e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.89  E-value: 6.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893   4 LLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAYKVIGPEPTGFLLKFNPSLSVVD 83
Cdd:PHA02878 186 LLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYCKDYDILKLLLEHGVDVNAKS 265

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568947893  84 KTHQNTPLHWAVAAGNVSAVdkLLEAGSSLDIRNAKGETPLDMALQSK------NQLISHM 138
Cdd:PHA02878 266 YILGLTALHSSIKSERKLKL--LLEYGADINSLNSYKLTPLSSAVKQYlcinigRILISNI 324
Ank_5 pfam13857
Ankyrin repeats (many copies);
72-127 8.53e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 48.88  E-value: 8.53e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 568947893   72 LLKFNPSLSVVDKTHQNTPLHWAVAAGNVSAVDKLLEAGSSLDIRNAKGETPLDMA 127
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1-134 2.13e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 53.35  E-value: 2.13e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893   1 MVILLLQHGADPTLID-GEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPlMLSAYKVIGPEPTGFLLKFNPSL 79
Cdd:PHA02878 149 ITKLLLSYGADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSP-LHHAVKHYNKPIVHILLENGAST 227

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568947893  80 SVVDKtHQNTPLHWAVAA-GNVSAVDKLLEAGSSLDIRNA-KGETPLDMALQSKNQL 134
Cdd:PHA02878 228 DARDK-CGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYiLGLTALHSSIKSERKL 283
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1-128 1.03e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.12  E-value: 1.03e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893   1 MVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLS----AYKVIGpeptgfLLKFN 76
Cdd:PHA02874 106 MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAikhnFFDIIK------LLLEK 179

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568947893  77 PSLSVVDKTHQNTPLHWAVAAGNVSAVDKLLEAGSSLDIRNAKGETPLDMAL 128
Cdd:PHA02874 180 GAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAI 231
Ank_4 pfam13637
Ankyrin repeats (many copies);
87-132 1.32e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 42.65  E-value: 1.32e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 568947893   87 QNTPLHWAVAAGNVSAVDKLLEAGSSLDIRNAKGETPLDMALQSKN 132
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGN 46
Ank_5 pfam13857
Ankyrin repeats (many copies);
5-56 2.20e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.95  E-value: 2.20e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 568947893    5 LLQHG-ADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPL 56
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
Ank_2 pfam12796
Ankyrin repeats (3 copies);
91-160 5.57e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.03  E-value: 5.57e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568947893   91 LHWAVAAGNVSAVDKLLEAGSSLDIRNAKGETPLDMALQSKN-QLISHMLrteAKMRANKQFRLWRWLHKC 160
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHlEIVKLLL---EHADVNLKDNGRTALHYA 68
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1-115 8.06e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 44.98  E-value: 8.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893   1 MVILLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLS-AYKVIgpEPTGFLLKFNPSL 79
Cdd:PHA02875 117 IMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAmAKGDI--AICKMLLDSGANI 194

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 568947893  80 SVVDKTHQNTPLHWAVAAGNVSAVDKLLEAGSSLDI 115
Cdd:PHA02875 195 DYFGKNGCVAALCYAIENNKIDIVRLFIKRGADCNI 230
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 3-139 1.03e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 45.05  E-value: 1.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893   3 ILLLQHGADPTLIDGEGFSSIHLAVLFQHMP-IIAYLISKGQSVNMTDVNGQTPLMLSAYKVIGPEPTGFLLKFNPSLSV 81
Cdd:PHA02876 257 LLLYDAGFSVNSIDDCKNTPLHHASQAPSLSrLVPKLLERGADVNAKNIKGETPLYLMAKNGYDTENIRTLIMLGADVNA 336

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568947893  82 VDKTHqNTPLHWAVAAG-NVSAVDKLLEAGSSLDIRNAKGETPLDMALQSKNQLISHML 139
Cdd:PHA02876 337 ADRLY-ITPLHQASTLDrNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTL 394
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 86-117 1.55e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.81  E-value: 1.55e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 568947893   86 HQNTPLHWAVA-AGNVSAVDKLLEAGSSLDIRN 117
Cdd:pfam00023   1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 4-59 6.08e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.58  E-value: 6.08e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 568947893   4 LLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLS 59
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELA 155
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 86-115 1.93e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.64  E-value: 1.93e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 568947893    86 HQNTPLHWAVAAGNVSAVDKLLEAGSSLDI 115
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
21-62 2.01e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.48  E-value: 2.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 568947893   21 SSIHLAVLFQHMPIIAYLISKGQSVNMTDVNGQTPLMLSAYK 62
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASN 44
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1-136 3.28e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.05  E-value: 3.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947893   1 MVILLLQHGADPTLIDGEGFSSIHLAVLFQH-MPIIAYLISKGQSVNMTDVNGQTPLMLSAYKVIGPEPTGFLLKFNPSL 79
Cdd:PHA02876 289 LVPKLLERGADVNAKNIKGETPLYLMAKNGYdTENIRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVITLLELGANV 368

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 568947893  80 SVVDkTHQNTPLHWAVAAGNVSAVDKLLEAGSSLDIRNAKGETPLDMALQSKNQLIS 136
Cdd:PHA02876 369 NARD-YCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALCGTNPYMS 424
Ank_4 pfam13637
Ankyrin repeats (many copies);
4-39 3.64e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 3.64e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 568947893    4 LLLQHGADPTLIDGEGFSSIHLAVLFQHMPIIAYLI 39
Cdd:pfam13637  19 LLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1-49 3.94e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 36.63  E-value: 3.94e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 568947893    1 MVILLLQHGAdpTLIDGEGFSSIHLAVLFQHMPIIAYLISKGQSVNMTD 49
Cdd:pfam12796  45 IVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 86-139 4.86e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.50  E-value: 4.86e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568947893  86 HQNTPLHWAVAAGNVSAVDKLLEAGSSLDIRNAKGETPLDMALQSKNQLISHML 139
Cdd:PTZ00322 114 DGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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