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Conserved domains on  [gi|568946275|ref|XP_006540287|]
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hydroxyproline dehydrogenase isoform X4 [Mus musculus]

Protein Classification

proline dehydrogenase family protein( domain architecture ID 1903339)

proline dehydrogenase family protein similar to human mitochondrial proline dehydrogenase 1 that converts proline to delta-1-pyrroline-5-carboxylate

EC:  1.5.5.-
Gene Ontology:  GO:0004657|GO:0006562|GO:0071949

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PLN02681 super family cl42973
proline dehydrogenase
47-373 2.82e-58

proline dehydrogenase


The actual alignment was detected with superfamily member PLN02681:

Pssm-ID: 215366 [Multi-domain]  Cd Length: 455  Bit Score: 195.69  E-value: 2.82e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946275  47 CAWPPLVTHGLAFQAWSQRLLGSRLSGALLRASIYGQFVAGETAEEVRNCVGQLQALGLQPLLAVPTEEEPDSTAktsev 126
Cdd:PLN02681  51 CAIGPLVDLGEWLLTSPLMVLGRAIVLALVKATFYSHFCAGEDAEEAARTVRRLWELGLGGILDYAAEDAGDNAA----- 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946275 127 wYEENLSAMLRCVDLSRALvdahgPARNSLMQLKVTALASTRLCKELS---AWIQRPRG------------SSELSPERL 191
Cdd:PLN02681 126 -CDRNLEKFLAAIRAAATL-----PPSSSSAAVKITALCPPSLLERVSdllRWQDRDPNgklpwkqwsfplFADSSPLYH 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946275 192 AEAMDSgrnlqlsCLSTEQNQHLQASLSRLHRVAQHARAKCVRLLVDAEYTFINPALSLLVAALAVRWNSPEEGgPWVWN 271
Cdd:PLN02681 200 ATSEPE-------PLTAEEERLLELAHERLQKLCERAAQLGVPLLIDAEYTSLQPAIDYITYDLAREFNKGKDR-PIVYG 271
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946275 272 TYQAYLKDTHQRLEQDAEAAHKAGLAFGVKLVRGAYLDKERSMTQLQGKEDCTQPDYEATSRSYSRCLELMLRCVSNHgp 351
Cdd:PLN02681 272 TYQAYLKDARERLRLDLERSEREGVPLGAKLVRGAYLSLERRLAASLGVPSPVHDTIQDTHACYNRCAEFLLEKASNG-- 349
                        330       340
                 ....*....|....*....|..
gi 568946275 352 PCHLMVASHNEESVRQATKRSS 373
Cdd:PLN02681 350 DGEVMLATHNVESGELAAAKMN 371
 
Name Accession Description Interval E-value
PLN02681 PLN02681
proline dehydrogenase
47-373 2.82e-58

proline dehydrogenase


Pssm-ID: 215366 [Multi-domain]  Cd Length: 455  Bit Score: 195.69  E-value: 2.82e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946275  47 CAWPPLVTHGLAFQAWSQRLLGSRLSGALLRASIYGQFVAGETAEEVRNCVGQLQALGLQPLLAVPTEEEPDSTAktsev 126
Cdd:PLN02681  51 CAIGPLVDLGEWLLTSPLMVLGRAIVLALVKATFYSHFCAGEDAEEAARTVRRLWELGLGGILDYAAEDAGDNAA----- 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946275 127 wYEENLSAMLRCVDLSRALvdahgPARNSLMQLKVTALASTRLCKELS---AWIQRPRG------------SSELSPERL 191
Cdd:PLN02681 126 -CDRNLEKFLAAIRAAATL-----PPSSSSAAVKITALCPPSLLERVSdllRWQDRDPNgklpwkqwsfplFADSSPLYH 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946275 192 AEAMDSgrnlqlsCLSTEQNQHLQASLSRLHRVAQHARAKCVRLLVDAEYTFINPALSLLVAALAVRWNSPEEGgPWVWN 271
Cdd:PLN02681 200 ATSEPE-------PLTAEEERLLELAHERLQKLCERAAQLGVPLLIDAEYTSLQPAIDYITYDLAREFNKGKDR-PIVYG 271
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946275 272 TYQAYLKDTHQRLEQDAEAAHKAGLAFGVKLVRGAYLDKERSMTQLQGKEDCTQPDYEATSRSYSRCLELMLRCVSNHgp 351
Cdd:PLN02681 272 TYQAYLKDARERLRLDLERSEREGVPLGAKLVRGAYLSLERRLAASLGVPSPVHDTIQDTHACYNRCAEFLLEKASNG-- 349
                        330       340
                 ....*....|....*....|..
gi 568946275 352 PCHLMVASHNEESVRQATKRSS 373
Cdd:PLN02681 350 DGEVMLATHNVESGELAAAKMN 371
Pro_dh pfam01619
Proline dehydrogenase;
218-369 1.26e-32

Proline dehydrogenase;


Pssm-ID: 426348 [Multi-domain]  Cd Length: 296  Bit Score: 123.76  E-value: 1.26e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946275  218 LSRLHRVAQHARAKCVRLLVDAEYTFINPA-----LSLLVAALAVRWNSpeeggpwVWNTYQAYLKDTHQRLEQDAEAAH 292
Cdd:pfam01619  83 LERLRPLCRLAKELGVRLNIDAEEADRLDLtldlfERLLAEPELRGWNG-------VGITLQAYLKDALAVLDWLLELAR 155
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568946275  293 KAGLAFGVKLVRGAYLDKERSMTQLQGKEDCTQPDYEATSRSYSRCLELMLrcvsNHGPPCHLMVASHNEESVRQAT 369
Cdd:pfam01619 156 RRGRPLGVRLVKGAYWDSEIKRAQQGGWPYPVFTRKEATDANYEACARFLL----ENHDRIYPQFATHNARSVAAAL 228
PutA COG0506
Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of ...
82-365 1.04e-14

Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of the Pathway/BioSystem: Proline degradation


Pssm-ID: 440272 [Multi-domain]  Cd Length: 975  Bit Score: 75.85  E-value: 1.04e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946275  82 GQFVAGETAEEVRNCVGQLQALGLQP---LL--AVPTEEEPDSTAKtsevwyeenlsamlRCVDLSRALvDAHGPARNSL 156
Cdd:COG0506  114 RRFVAGETIEEALKAARKLRAKGYRVsldLLgeAVLTEAEAERYLD--------------AYLEALEAI-GAAGVDRPGV 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946275 157 mQLKVTALAStrlckELSAWiQRPRGSSELSP--ERLAE-AMDSGRNLqlsCLSTEQNQHLQASLSRLHRVAQHARAKcv 233
Cdd:COG0506  179 -SVKLSALGP-----RYSPA-QRERVVEELLErlRPLARaAREAGIFV---TIDMEEYDRLDLTLDVFERLLADPELA-- 246
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946275 234 rllvdaeytfinpalsllvaalavrwnspeeGGPWVWNTYQAYLKDTHQRLEQDAEAAHKAGLAFGVKLVRGAYLDKERS 313
Cdd:COG0506  247 -------------------------------GWPGVGIVLQAYLKRAEADLDRLAALARRGGRRIRVRLVKGAYWDPEIV 295
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568946275 314 MTQLQGKEDCTQPDYEATSRSYSRCLELMLRcvsnHGPPCHLMVASHNEESV 365
Cdd:COG0506  296 RAQVHGWPYPVFTRKADTDANYLRCARKLLE----AGDAIYPQFATHNARTI 343
 
Name Accession Description Interval E-value
PLN02681 PLN02681
proline dehydrogenase
47-373 2.82e-58

proline dehydrogenase


Pssm-ID: 215366 [Multi-domain]  Cd Length: 455  Bit Score: 195.69  E-value: 2.82e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946275  47 CAWPPLVTHGLAFQAWSQRLLGSRLSGALLRASIYGQFVAGETAEEVRNCVGQLQALGLQPLLAVPTEEEPDSTAktsev 126
Cdd:PLN02681  51 CAIGPLVDLGEWLLTSPLMVLGRAIVLALVKATFYSHFCAGEDAEEAARTVRRLWELGLGGILDYAAEDAGDNAA----- 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946275 127 wYEENLSAMLRCVDLSRALvdahgPARNSLMQLKVTALASTRLCKELS---AWIQRPRG------------SSELSPERL 191
Cdd:PLN02681 126 -CDRNLEKFLAAIRAAATL-----PPSSSSAAVKITALCPPSLLERVSdllRWQDRDPNgklpwkqwsfplFADSSPLYH 199
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946275 192 AEAMDSgrnlqlsCLSTEQNQHLQASLSRLHRVAQHARAKCVRLLVDAEYTFINPALSLLVAALAVRWNSPEEGgPWVWN 271
Cdd:PLN02681 200 ATSEPE-------PLTAEEERLLELAHERLQKLCERAAQLGVPLLIDAEYTSLQPAIDYITYDLAREFNKGKDR-PIVYG 271
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946275 272 TYQAYLKDTHQRLEQDAEAAHKAGLAFGVKLVRGAYLDKERSMTQLQGKEDCTQPDYEATSRSYSRCLELMLRCVSNHgp 351
Cdd:PLN02681 272 TYQAYLKDARERLRLDLERSEREGVPLGAKLVRGAYLSLERRLAASLGVPSPVHDTIQDTHACYNRCAEFLLEKASNG-- 349
                        330       340
                 ....*....|....*....|..
gi 568946275 352 PCHLMVASHNEESVRQATKRSS 373
Cdd:PLN02681 350 DGEVMLATHNVESGELAAAKMN 371
Pro_dh pfam01619
Proline dehydrogenase;
218-369 1.26e-32

Proline dehydrogenase;


Pssm-ID: 426348 [Multi-domain]  Cd Length: 296  Bit Score: 123.76  E-value: 1.26e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946275  218 LSRLHRVAQHARAKCVRLLVDAEYTFINPA-----LSLLVAALAVRWNSpeeggpwVWNTYQAYLKDTHQRLEQDAEAAH 292
Cdd:pfam01619  83 LERLRPLCRLAKELGVRLNIDAEEADRLDLtldlfERLLAEPELRGWNG-------VGITLQAYLKDALAVLDWLLELAR 155
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568946275  293 KAGLAFGVKLVRGAYLDKERSMTQLQGKEDCTQPDYEATSRSYSRCLELMLrcvsNHGPPCHLMVASHNEESVRQAT 369
Cdd:pfam01619 156 RRGRPLGVRLVKGAYWDSEIKRAQQGGWPYPVFTRKEATDANYEACARFLL----ENHDRIYPQFATHNARSVAAAL 228
PutA COG0506
Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of ...
82-365 1.04e-14

Proline dehydrogenase [Amino acid transport and metabolism]; Proline dehydrogenase is part of the Pathway/BioSystem: Proline degradation


Pssm-ID: 440272 [Multi-domain]  Cd Length: 975  Bit Score: 75.85  E-value: 1.04e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946275  82 GQFVAGETAEEVRNCVGQLQALGLQP---LL--AVPTEEEPDSTAKtsevwyeenlsamlRCVDLSRALvDAHGPARNSL 156
Cdd:COG0506  114 RRFVAGETIEEALKAARKLRAKGYRVsldLLgeAVLTEAEAERYLD--------------AYLEALEAI-GAAGVDRPGV 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946275 157 mQLKVTALAStrlckELSAWiQRPRGSSELSP--ERLAE-AMDSGRNLqlsCLSTEQNQHLQASLSRLHRVAQHARAKcv 233
Cdd:COG0506  179 -SVKLSALGP-----RYSPA-QRERVVEELLErlRPLARaAREAGIFV---TIDMEEYDRLDLTLDVFERLLADPELA-- 246
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568946275 234 rllvdaeytfinpalsllvaalavrwnspeeGGPWVWNTYQAYLKDTHQRLEQDAEAAHKAGLAFGVKLVRGAYLDKERS 313
Cdd:COG0506  247 -------------------------------GWPGVGIVLQAYLKRAEADLDRLAALARRGGRRIRVRLVKGAYWDPEIV 295
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 568946275 314 MTQLQGKEDCTQPDYEATSRSYSRCLELMLRcvsnHGPPCHLMVASHNEESV 365
Cdd:COG0506  296 RAQVHGWPYPVFTRKADTDANYLRCARKLLE----AGDAIYPQFATHNARTI 343
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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