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Conserved domains on  [gi|755519615|ref|XP_006540021|]
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leucine-rich repeat LGI family member 4 isoform X2 [Mus musculus]

Protein Classification

LRR_8 and EPTP domain-containing protein( domain architecture ID 12158096)

LRR_8 and EPTP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
15-75 1.01e-13

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.62  E-value: 1.01e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755519615   15 PSLHLLLFTSNTFSVIEGDAFIGLSYLQYLFIEDNKIGSISKNALRGLRSLTHLSLANNHL 75
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 335-376 8.25e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 50.93  E-value: 8.25e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 755519615  335 RFERRTDIPEAeDVYATKHFQAGGDVFLCLTRYIGDSMVMRW 376
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 70-131 3.39e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 56.24  E-value: 3.39e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755519615    70 LANNHLEALPRFLFRGLETLTHVDLRGNPFQCDCRVLWLLQWMPTVNASV---GTGACAGPPAVA 131
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALA 66
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 380-419 1.03e-03

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 36.68  E-value: 1.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 755519615  380 MFRLLQQLPSRGSHVFQPLLIARDQLAILGSDFAFSQVFR 419
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYR 40
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 159-189 4.43e-03

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


:

Pssm-ID: 461033  Cd Length: 41  Bit Score: 34.75  E-value: 4.43e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 755519615  159 SALSVESFSYQGEPHMVLAqPFAGRCLILVW 189
Cdd:pfam03736  12 GARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
15-75 1.01e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.62  E-value: 1.01e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755519615   15 PSLHLLLFTSNTFSVIEGDAFIGLSYLQYLFIEDNKIGSISKNALRGLRSLTHLSLANNHL 75
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-99 3.55e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 3.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519615  10 SFLKMPSLHLLLFTSNTFSVIeGDAFIGLSYLQYLFIEDNKIGSISKnALRGLRSLTHLSLANNHLEALPRFLfRGLETL 89
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPL-ANLTNL 230

                         90
                 ....*....|
gi 755519615  90 THVDLRGNPF 99
Cdd:COG4886  231 ETLDLSNNQL 240
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 335-376 8.25e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 50.93  E-value: 8.25e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 755519615  335 RFERRTDIPEAeDVYATKHFQAGGDVFLCLTRYIGDSMVMRW 376
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 70-131 3.39e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 56.24  E-value: 3.39e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755519615    70 LANNHLEALPRFLFRGLETLTHVDLRGNPFQCDCRVLWLLQWMPTVNASV---GTGACAGPPAVA 131
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALA 66
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 41-99 5.14e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 5.14e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755519615  41 LQYLFIEDNKIGSISKnaLRGLRSLTHLSLANNHLEALPRF--LFRGLETLTHVDLRGNPF 99
Cdd:cd21340  122 LRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEELldLLSSWPSLRELDLTGNPV 180
LRRCT smart00082
Leucine rich repeat C-terminal domain;
97-145 2.31e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 44.34  E-value: 2.31e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 755519615    97 NPFQCDCRVLWLLQWMPTVNASVGTGA--CAGPPAVAQiQLNHLDPKKFKC 145
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDlrCASPSSLRG-PLLELLHSEFKC 50
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 64-106 9.58e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 9.58e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 755519615   64 SLTHLSLANNHLEALPrfLFRGLETLTHVDLRGNPFQCDCRVL 106
Cdd:pfam12799   2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKITDLSDL 42
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 380-419 1.03e-03

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 36.68  E-value: 1.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 755519615  380 MFRLLQQLPSRGSHVFQPLLIARDQLAILGSDFAFSQVFR 419
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYR 40
LRR smart00370
Leucine-rich repeats, outliers;
62-85 1.75e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 1.75e-03
                           10        20
                   ....*....|....*....|....
gi 755519615    62 LRSLTHLSLANNHLEALPRFLFRG 85
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 159-189 4.43e-03

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 34.75  E-value: 4.43e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 755519615  159 SALSVESFSYQGEPHMVLAqPFAGRCLILVW 189
Cdd:pfam03736  12 GARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
 
Name Accession Description Interval E-value
LRR_8 pfam13855
Leucine rich repeat;
15-75 1.01e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.62  E-value: 1.01e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755519615   15 PSLHLLLFTSNTFSVIEGDAFIGLSYLQYLFIEDNKIGSISKNALRGLRSLTHLSLANNHL 75
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-99 3.55e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 3.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519615  10 SFLKMPSLHLLLFTSNTFSVIeGDAFIGLSYLQYLFIEDNKIGSISKnALRGLRSLTHLSLANNHLEALPRFLfRGLETL 89
Cdd:COG4886  154 PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEPL-ANLTNL 230

                         90
                 ....*....|
gi 755519615  90 THVDLRGNPF 99
Cdd:COG4886  231 ETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-99 9.68e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.41  E-value: 9.68e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519615  10 SFLKMPSLHLLLFTSNTFSVIeGDAFIGLSYLQYLFIEDNKIGSISKnALRGLRSLTHLSLANNHLEALPRFLfrGLETL 89
Cdd:COG4886  177 ELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPELG--NLTNL 252

                         90
                 ....*....|
gi 755519615  90 THVDLRGNPF 99
Cdd:COG4886  253 EELDLSNNQL 262
LRR_8 pfam13855
Leucine rich repeat;
39-99 9.71e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 9.71e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755519615   39 SYLQYLFIEDNKIGSISKNALRGLRSLTHLSLANNHLEALPRFLFRGLETLTHVDLRGNPF 99
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 335-376 8.25e-09

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 50.93  E-value: 8.25e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 755519615  335 RFERRTDIPEAeDVYATKHFQAGGDVFLCLTRYIGDSMVMRW 376
Cdd:pfam03736   1 KFVPYQTIPTR-GARDVEPFSIGGDLFLAVANFSGDSVIYRW 41
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
13-99 9.77e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 57.25  E-value: 9.77e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519615  13 KMPSLHLLLFTSNTFSVIeGDAFIGLSYLQYLFIEDNKIGSISknALRGLRSLTHLSLANNHLEALPRFLfrGLETLTHV 92
Cdd:COG4886  203 NLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTL 277


                 ....*..
gi 755519615  93 DLRGNPF 99
Cdd:COG4886  278 DLSNNQL 284
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 70-131 3.39e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 56.24  E-value: 3.39e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755519615    70 LANNHLEALPRFLFRGLETLTHVDLRGNPFQCDCRVLWLLQWMPTVNASV---GTGACAGPPAVA 131
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALA 66
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
26-97 1.28e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.78  E-value: 1.28e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755519615  26 TFSVIEGDAFIGLSYLQYLFIEDNKIGSISKnALRGLRSLTHLSLANNHLEALPRFLFrGLETLTHVDLRGN 97
Cdd:COG4886  100 ELDLSGNEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNN 169
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 41-99 5.14e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 5.14e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755519615  41 LQYLFIEDNKIGSISKnaLRGLRSLTHLSLANNHLEALPRF--LFRGLETLTHVDLRGNPF 99
Cdd:cd21340  122 LRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEELldLLSSWPSLRELDLTGNPV 180
LRRCT smart00082
Leucine rich repeat C-terminal domain;
97-145 2.31e-06

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 44.34  E-value: 2.31e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 755519615    97 NPFQCDCRVLWLLQWMPTVNASVGTGA--CAGPPAVAQiQLNHLDPKKFKC 145
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVDlrCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
4-51 5.31e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 5.31e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 755519615    4 SRLKAGSFLKMPSLHLLLFTSNTFSVIEGDAFIGLSYLQYLFIEDNKI 51
Cdd:pfam13855  14 TSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
19-99 4.74e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 4.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755519615  19 LLLFTSNTFSVIEGDAFIGLSYLQYLFIEDNkigsiskNALRGLRSLTHLSLANNHLEALPRFLFRgLETLTHVDLRGNP 98
Cdd:COG4886   76 LLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQ 147


                 .
gi 755519615  99 F 99
Cdd:COG4886  148 L 148
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
10-78 6.37e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 6.37e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755519615  10 SFLKMPSLHLLLFTSNTFSVIEgdAFIGLSYLQYLFIEDNKIGSISKNAlrGLRSLTHLSLANNHLEAL 78
Cdd:COG4886  223 PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDL 287
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 64-106 9.58e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 9.58e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 755519615   64 SLTHLSLANNHLEALPrfLFRGLETLTHVDLRGNPFQCDCRVL 106
Cdd:pfam12799   2 NLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNKITDLSDL 42
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 380-419 1.03e-03

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 36.68  E-value: 1.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 755519615  380 MFRLLQQLPSRGSHVFQPLLIARDQLAILGSDFAFSQVFR 419
Cdd:pfam03736   1 KFVPYQTIPTRGARDVEPFSIGGDLFLAVANFSGDSVIYR 40
LRR smart00370
Leucine-rich repeats, outliers;
62-85 1.75e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 1.75e-03
                           10        20
                   ....*....|....*....|....
gi 755519615    62 LRSLTHLSLANNHLEALPRFLFRG 85
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
62-85 1.75e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 1.75e-03
                           10        20
                   ....*....|....*....|....
gi 755519615    62 LRSLTHLSLANNHLEALPRFLFRG 85
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-97 2.03e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 2.03e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755519615  43 YLFieDNKIGSISKnaLRGLRSLTHLSLANNHLEALPRflFRGLETLTHVDLRGN 97
Cdd:cd21340   30 YLY--DNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN 78
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 37-81 2.39e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.38  E-value: 2.39e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 755519615  37 GLSYLQYLFIEDNKIGSIS--KNALRGLRSLTHLSLANNHLEALPRF 81
Cdd:cd21340  140 PLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKPKY 186
EPTP pfam03736
EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, ...
 159-189 4.43e-03

EPTP domain; Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.


Pssm-ID: 461033  Cd Length: 41  Bit Score: 34.75  E-value: 4.43e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 755519615  159 SALSVESFSYQGEPHMVLAqPFAGRCLILVW 189
Cdd:pfam03736  12 GARDVEPFSIGGDLFLAVA-NFSGDSVIYRW 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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