NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568927369|ref|XP_006538312|]
View 

U4/U6 small nuclear ribonucleoprotein Prp4 isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-276 4.49e-76

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 237.12  E-value: 4.49e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  13 KLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSG 92
Cdd:COG2319  145 RLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL--------LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  93 RFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINF 172
Cdd:COG2319  217 KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369 173 SPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGDFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKV 252
Cdd:COG2319  297 SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAV 375

                        250       260
                 ....*....|....*....|....
gi 568927369 253 MGLDISSDGQLIATCSYDRTFKLW 276
Cdd:COG2319  376 TSVAFSPDGRTLASGSADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-276 4.49e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 237.12  E-value: 4.49e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  13 KLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSG 92
Cdd:COG2319  145 RLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL--------LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  93 RFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINF 172
Cdd:COG2319  217 KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369 173 SPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGDFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKV 252
Cdd:COG2319  297 SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAV 375

                        250       260
                 ....*....|....*....|....
gi 568927369 253 MGLDISSDGQLIATCSYDRTFKLW 276
Cdd:COG2319  376 TSVAFSPDGRTLASGSADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-276 3.43e-70

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 218.36  E-value: 3.43e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369   8 RSGLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVM 87
Cdd:cd00200   29 GDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY--------LASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  88 WHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEI 167
Cdd:cd00200  101 FSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEV 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369 168 YGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGDFLLTGAYDNTAKIWTHPGWSPLKTLAG 247
Cdd:cd00200  181 NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSG 259

                        250       260
                 ....*....|....*....|....*....
gi 568927369 248 HEGKVMGLDISSDGQLIATCSYDRTFKLW 276
Cdd:cd00200  260 HTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 153-192 3.74e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 3.74e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568927369   153 TGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWD 192
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
154-192 2.93e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 2.93e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568927369  154 GRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWD 192
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 135-276 3.80e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.24  E-value: 3.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369 135 SLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSP-NGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNlVTGVK 213
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQ 624

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568927369 214 FEPIHGDFLLTGAYDNTAKIWT--HPGWsPLKTLAGHEGKVMGLDISSDGQLIATcSYDRTFKLW 276
Cdd:PLN00181 625 FPSESGRSLAFGSADHKVYYYDlrNPKL-PLCTMIGHSKTVSYVRFVDSSTLVSS-STDNTLKLW 687
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-276 4.49e-76

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 237.12  E-value: 4.49e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  13 KLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSG 92
Cdd:COG2319  145 RLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL--------LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  93 RFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINF 172
Cdd:COG2319  217 KLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369 173 SPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGDFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKV 252
Cdd:COG2319  297 SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAV 375

                        250       260
                 ....*....|....*....|....
gi 568927369 253 MGLDISSDGQLIATCSYDRTFKLW 276
Cdd:COG2319  376 TSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
13-276 2.66e-71

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 224.79  E-value: 2.66e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  13 KLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSG 92
Cdd:COG2319  103 RLWDLATGLLLRTLTGHTGAVRSVAFSPDGKT--------LASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDG 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  93 RFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINF 172
Cdd:COG2319  175 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369 173 SPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGDFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKV 252
Cdd:COG2319  255 SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 333

                        250       260
                 ....*....|....*....|....
gi 568927369 253 MGLDISSDGQLIATCSYDRTFKLW 276
Cdd:COG2319  334 RSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-276 3.43e-70

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 218.36  E-value: 3.43e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369   8 RSGLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVM 87
Cdd:cd00200   29 GDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY--------LASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVA 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  88 WHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEI 167
Cdd:cd00200  101 FSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEV 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369 168 YGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGDFLLTGAYDNTAKIWTHPGWSPLKTLAG 247
Cdd:cd00200  181 NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSG 259

                        250       260
                 ....*....|....*....|....*....
gi 568927369 248 HEGKVMGLDISSDGQLIATCSYDRTFKLW 276
Cdd:cd00200  260 HTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
13-276 4.33e-65

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 208.61  E-value: 4.33e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  13 KLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSG 92
Cdd:COG2319   61 LLLDAAAGALLATLLGHTAAVLSVAFSPDGRL--------LASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDG 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  93 RFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINF 172
Cdd:COG2319  133 KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 212

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369 173 SPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPiHGDFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKV 252
Cdd:COG2319  213 SPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGV 291

                        250       260
                 ....*....|....*....|....
gi 568927369 253 MGLDISSDGQLIATCSYDRTFKLW 276
Cdd:COG2319  292 NSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 22-276 1.17e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 201.41  E-value: 1.17e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  22 LLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYD 101
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKL--------LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369 102 RSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIAT 181
Cdd:cd00200   73 KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVAS 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369 182 GSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIhGDFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDG 261
Cdd:cd00200  153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD-GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDG 231

                        250
                 ....*....|....*
gi 568927369 262 QLIATCSYDRTFKLW 276
Cdd:cd00200  232 YLLASGSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
50-276 9.12e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 187.04  E-value: 9.12e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  50 DVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIA 129
Cdd:COG2319   48 GARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVA 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369 130 FHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNLV 209
Cdd:COG2319  128 FSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAV 207

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568927369 210 TGVKFEPiHGDFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 276
Cdd:COG2319  208 RSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
45-276 4.47e-49

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 167.01  E-value: 4.47e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  45 SLDQKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMG 124
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369 125 VYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPA 204
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568927369 205 HQNLVTGVKFEPiHGDFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 276
Cdd:COG2319  161 HSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLW 231
WD40 COG2319
WD40 repeat [General function prediction only];
13-194 2.65e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 157.38  E-value: 2.65e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  13 KLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSG 92
Cdd:COG2319  229 RLWDLATGKLLRTLTGHSGSVRSVAFSPDGRL--------LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDG 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  93 RFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINF 172
Cdd:COG2319  301 KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380

                        170       180
                 ....*....|....*....|..
gi 568927369 173 SPNGYHIATGSGDNTCKVWDLR 194
Cdd:COG2319  381 SPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-192 8.99e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 134.77  E-value: 8.99e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  12 CKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPS 91
Cdd:cd00200  117 IKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF--------VASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  92 GRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGIN 171
Cdd:cd00200  189 GEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLA 268

                        170       180
                 ....*....|....*....|.
gi 568927369 172 FSPNGYHIATGSGDNTCKVWD 192
Cdd:cd00200  269 WSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
13-153 1.05e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 113.08  E-value: 1.05e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  13 KLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSG 92
Cdd:COG2319  271 RLWDLATGELLRTLTGHSGGVNSVAFSPDGKL--------LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG 342

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568927369  93 RFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRT 153
Cdd:COG2319  343 KTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-108 3.13e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.60  E-value: 3.13e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  10 GLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWH 89
Cdd:cd00200  199 GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL--------LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWS 270

                         90
                 ....*....|....*....
gi 568927369  90 PSGRFLGTTCYDRSWRLWD 108
Cdd:cd00200  271 PDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 153-192 3.74e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 3.74e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568927369   153 TGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWD 192
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
154-192 2.93e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 2.93e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568927369  154 GRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWD 192
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
239-276 1.66e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 1.66e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568927369  239 WSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 276
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 239-276 1.73e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 1.73e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 568927369   239 WSPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLW 276
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 135-276 3.80e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.24  E-value: 3.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369 135 SLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSP-NGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQNlVTGVK 213
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQ 624

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568927369 214 FEPIHGDFLLTGAYDNTAKIWT--HPGWsPLKTLAGHEGKVMGLDISSDGQLIATcSYDRTFKLW 276
Cdd:PLN00181 625 FPSESGRSLAFGSADHKVYYYDlrNPKL-PLCTMIGHSKTVSYVRFVDSSTLVSS-STDNTLKLW 687
PTZ00421 PTZ00421
coronin; Provisional
 15-124 5.71e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.20  E-value: 5.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  15 WSVP------DCS--LLHtLRGHNTNVGAIVFHPKStvsldqKDVnLASCAADGSVKLWSLDSDEPVADIEGHTVRVARV 86
Cdd:PTZ00421 103 WGIPeegltqNISdpIVH-LQGHTKKVGIVSFHPSA------MNV-LASAGADMVVNVWDVERGKAVEVIKCHSDQITSL 174

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568927369  87 MWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMG 124
Cdd:PTZ00421 175 EWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASA 212
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-66 1.05e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.79  E-value: 1.05e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369   7 DRSGLCKLWSVPDCSLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWS 66
Cdd:cd00200  238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR--------LASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 69-108 2.43e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 2.43e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568927369    69 SDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWD 108
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 77-206 3.47e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.88  E-value: 3.47e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  77 EGHTVRVARVMWHPSGRFlgTTCYDRSWRLWDLEAQ-------EEILHQEGHSMGVYDIAFHQD--GSLAgTGGLDAFGR 147
Cdd:PTZ00421  75 EGPIIDVAFNPFDPQKLF--TASEDGTIMGWGIPEEgltqnisDPIVHLQGHTKKVGIVSFHPSamNVLA-SAGADMVVN 151

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568927369 148 VWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCVYTIPAHQ 206
Cdd:PTZ00421 152 VWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHA 210
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 195-234 6.44e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 6.44e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 568927369   195 QRRCVYTIPAHQNLVTGVKFEPiHGDFLLTGAYDNTAKIW 234
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
196-234 6.54e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 6.54e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568927369  196 RRCVYTIPAHQNLVTGVKFEPiHGDFLLTGAYDNTAKIW 234
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 26-191 9.92e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 9.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  26 LRGHNTNVGAIVFHP-KSTVsldqkdvnLASCAADGSVKLWSL-DSDEPVADIE-------GHTVRVARVMWHPSGRF-L 95
Cdd:PTZ00420  70 LKGHTSSILDLQFNPcFSEI--------LASGSEDLTIRVWEIpHNDESVKEIKdpqcilkGHKKKISIIDWNPMNYYiM 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369  96 GTTCYDRSWRLWDLEAQE---EILHQEGHSMGVYDIAfhqdGS-LAGTGgldafgrvwdlrTGRCIMFLEGHLKEIygin 171
Cdd:PTZ00420 142 CSSGFDSFVNIWDIENEKrafQINMPKKLSSLKWNIK----GNlLSGTC------------VGKHMHIIDPRKQEI---- 201

                        170       180
                 ....*....|....*....|
gi 568927369 172 fsPNGYHIATGsGDNTCKVW 191
Cdd:PTZ00420 202 --ASSFHIHDG-GKNTKNIW 218
WD40 pfam00400
WD domain, G-beta repeat;
71-108 1.59e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.59e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 568927369   71 EPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWD 108
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 21-66 4.61e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 4.61e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 568927369    21 SLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWS 66
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKY--------LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
21-66 6.75e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 6.75e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 568927369   21 SLLHTLRGHNTNVGAIVFHPKSTVsldqkdvnLASCAADGSVKLWS 66
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKL--------LASGSDDGTVKVWD 39
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
159-208 1.20e-03

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 40.01  E-value: 1.20e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568927369 159 FLEGHLKEIYGINFSPNGYHIATGSgDNTCKVWDLR-QRRCVYTIPAHQNL 208
Cdd:COG5170  275 FFEEIVSSISDFKFSDNGRYILSRD-YLTVKIWDVNmAKNPIKTIPMHCDL 324
PTZ00420 PTZ00420
coronin; Provisional
 119-202 2.24e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.16  E-value: 2.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568927369 119 EGHSMGVYDIAFHQDGS-LAGTGGLDAFGRVWDLRTG----------RCImfLEGHLKEIYGINFSPNGYHIATGSG-DN 186
Cdd:PTZ00420  71 KGHTSSILDLQFNPCFSeILASGSEDLTIRVWEIPHNdesvkeikdpQCI--LKGHKKKISIIDWNPMNYYIMCSSGfDS 148

                         90
                 ....*....|....*.
gi 568927369 187 TCKVWDLRQRRCVYTI 202
Cdd:PTZ00420 149 FVNIWDIENEKRAFQI 164
WD40 pfam00400
WD domain, G-beta repeat;
119-150 2.58e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 2.58e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 568927369  119 EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWD 150
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 119-150 7.21e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 33.83  E-value: 7.21e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 568927369   119 EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWD 150
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH