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Conserved domains on  [gi|568926796|ref|XP_006538034|]
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nibrin isoform X4 [Mus musculus]

Protein Classification

BRCT domain-containing protein( domain architecture ID 11618337)

BRCT (BRCA1 C-terminus) domain-containing protein may interact with DNA, and participate in DNA-damage checkpoint or DNA-repair pathways

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NIBRIN_BRCT_II pfam16508
Second BRCT domain on Nijmegen syndrome breakage protein;
66-174 3.99e-33

Second BRCT domain on Nijmegen syndrome breakage protein;


:

Pssm-ID: 465151  Cd Length: 118  Bit Score: 122.79  E-value: 3.99e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926796   66 ERKQIFKGKTFVFLNAKQHKKLSSAVAFGGGEARLMAEDDEEEQ-------------SFFSAPGTCVVDVGITNTqliis 132
Cdd:pfam16508   2 ERKTLFEGKTFVFLDQKQFERLSPPITNGGGKALLYEVEPGETTpddfvryvknvgsELLTGKGVVVVRFRPKKS----- 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 568926796  133 hSQKKWIHLIMDTLQRN-GLRPIPEAEIGLAVIFMTTENYCNP 174
Cdd:pfam16508  77 -SNEEWIASFENELALRlGQRVIEQSEFLDAILHCSASKLCNP 118
Nbs1_C pfam08599
DNA damage repair protein Nbs1; This C terminal region of the DNA damage repair protein Nbs1 ...
 530-591 4.01e-31

DNA damage repair protein Nbs1; This C terminal region of the DNA damage repair protein Nbs1 has been identified to be necessary for the binding of Mre11 and Tel1.


:

Pssm-ID: 462531  Cd Length: 62  Bit Score: 115.09  E-value: 4.01e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568926796  530 KNFKKFKKATFPGAGKLPHIIGGSDLVGHHARKNTELEEWLKQEMEVQKQQAKEESLADDLF 591
Cdd:pfam08599   1 KNFKKFRKVAYPGAGGLPHIIGGSDLLVHNRGKNSELEEWLKQAMEEESQSAREESLADDLF 62
BRCT super family cl00038
C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The ...
 1-33 7.90e-12

C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains; The BRCT (BRCA1 C-terminus) domain is found within many DNA damage repair and cell cycle checkpoint proteins. BRCT domains interact with each other forming homo/hetero BRCT multimers, but are also involved in BRCT-non-BRCT interactions and interactions within DNA strand breaks. BRCT tandem repeats bind to phosphopeptides; it has been shown that the repeats in human BRCA1 bind specifically to pS-X-X-F motifs, mediating the interaction between BRCA1 and the DNA helicase BACH1, or BRCA1 and CtIP, a transcriptional corepressor. It is assumed that BRCT repeats play similar roles in many signaling pathways associated with the response to DNA damage.


The actual alignment was detected with superfamily member cd17741:

Pssm-ID: 469589 [Multi-domain]  Cd Length: 74  Bit Score: 61.08  E-value: 7.90e-12
                         10        20        30
                 ....*....|....*....|....*....|...
gi 568926796   1 MSAVKVTIKTICALICGRPIIKPEYFSEFLKAV 33
Cdd:cd17741   42 MSKIKVTVKVICALISGKPIVTPEYLDALLEAI 74
 
Name Accession Description Interval E-value
NIBRIN_BRCT_II pfam16508
Second BRCT domain on Nijmegen syndrome breakage protein;
66-174 3.99e-33

Second BRCT domain on Nijmegen syndrome breakage protein;


Pssm-ID: 465151  Cd Length: 118  Bit Score: 122.79  E-value: 3.99e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926796   66 ERKQIFKGKTFVFLNAKQHKKLSSAVAFGGGEARLMAEDDEEEQ-------------SFFSAPGTCVVDVGITNTqliis 132
Cdd:pfam16508   2 ERKTLFEGKTFVFLDQKQFERLSPPITNGGGKALLYEVEPGETTpddfvryvknvgsELLTGKGVVVVRFRPKKS----- 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 568926796  133 hSQKKWIHLIMDTLQRN-GLRPIPEAEIGLAVIFMTTENYCNP 174
Cdd:pfam16508  77 -SNEEWIASFENELALRlGQRVIEQSEFLDAILHCSASKLCNP 118
Nbs1_C pfam08599
DNA damage repair protein Nbs1; This C terminal region of the DNA damage repair protein Nbs1 ...
 530-591 4.01e-31

DNA damage repair protein Nbs1; This C terminal region of the DNA damage repair protein Nbs1 has been identified to be necessary for the binding of Mre11 and Tel1.


Pssm-ID: 462531  Cd Length: 62  Bit Score: 115.09  E-value: 4.01e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568926796  530 KNFKKFKKATFPGAGKLPHIIGGSDLVGHHARKNTELEEWLKQEMEVQKQQAKEESLADDLF 591
Cdd:pfam08599   1 KNFKKFRKVAYPGAGGLPHIIGGSDLLVHNRGKNSELEEWLKQAMEEESQSAREESLADDLF 62
BRCT_nibrin cd17741
BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage ...
 1-33 7.90e-12

BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage syndrome protein 1 (NBS1), or cell cycle regulatory protein p95, is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The BRCT (Breast Cancer Suppressor Protein BRCA1, carboxy-terminal) domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is absent in this group.


Pssm-ID: 349372 [Multi-domain]  Cd Length: 74  Bit Score: 61.08  E-value: 7.90e-12
                         10        20        30
                 ....*....|....*....|....*....|...
gi 568926796   1 MSAVKVTIKTICALICGRPIIKPEYFSEFLKAV 33
Cdd:cd17741   42 MSKIKVTVKVICALISGKPIVTPEYLDALLEAI 74
 
Name Accession Description Interval E-value
NIBRIN_BRCT_II pfam16508
Second BRCT domain on Nijmegen syndrome breakage protein;
66-174 3.99e-33

Second BRCT domain on Nijmegen syndrome breakage protein;


Pssm-ID: 465151  Cd Length: 118  Bit Score: 122.79  E-value: 3.99e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568926796   66 ERKQIFKGKTFVFLNAKQHKKLSSAVAFGGGEARLMAEDDEEEQ-------------SFFSAPGTCVVDVGITNTqliis 132
Cdd:pfam16508   2 ERKTLFEGKTFVFLDQKQFERLSPPITNGGGKALLYEVEPGETTpddfvryvknvgsELLTGKGVVVVRFRPKKS----- 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 568926796  133 hSQKKWIHLIMDTLQRN-GLRPIPEAEIGLAVIFMTTENYCNP 174
Cdd:pfam16508  77 -SNEEWIASFENELALRlGQRVIEQSEFLDAILHCSASKLCNP 118
Nbs1_C pfam08599
DNA damage repair protein Nbs1; This C terminal region of the DNA damage repair protein Nbs1 ...
 530-591 4.01e-31

DNA damage repair protein Nbs1; This C terminal region of the DNA damage repair protein Nbs1 has been identified to be necessary for the binding of Mre11 and Tel1.


Pssm-ID: 462531  Cd Length: 62  Bit Score: 115.09  E-value: 4.01e-31
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568926796  530 KNFKKFKKATFPGAGKLPHIIGGSDLVGHHARKNTELEEWLKQEMEVQKQQAKEESLADDLF 591
Cdd:pfam08599   1 KNFKKFRKVAYPGAGGLPHIIGGSDLLVHNRGKNSELEEWLKQAMEEESQSAREESLADDLF 62
BRCT_nibrin cd17741
BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage ...
 1-33 7.90e-12

BRCT domain of nibrin and similar proteins; Nibrin (NBN), also termed Nijmegen breakage syndrome protein 1 (NBS1), or cell cycle regulatory protein p95, is a novel DNA double-strand break repair protein that is mutated in Nijmegen breakage syndrome. It is a component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The BRCT (Breast Cancer Suppressor Protein BRCA1, carboxy-terminal) domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions within DNA strand breaks. The Trp-X-X-X-Cys/Ser signature motif of the BRCT family is absent in this group.


Pssm-ID: 349372 [Multi-domain]  Cd Length: 74  Bit Score: 61.08  E-value: 7.90e-12
                         10        20        30
                 ....*....|....*....|....*....|...
gi 568926796   1 MSAVKVTIKTICALICGRPIIKPEYFSEFLKAV 33
Cdd:cd17741   42 MSKIKVTVKVICALISGKPIVTPEYLDALLEAI 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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