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Conserved domains on  [gi|568935430|ref|XP_006534905|]
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RE1-silencing transcription factor isoform X1 [Mus musculus]

Protein Classification

zf-H2C2_2 and zf-H2C2_5 domain-containing protein( domain architecture ID 11473584)

protein containing domains COG5048, zf-H2C2_2, and zf-H2C2_5

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-338 6.10e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 6.10e-06
                           10        20
                   ....*....|....*....|....*.
gi 568935430   313 HLTRHMRTHSGEKPFKCDQCNYVASN 338
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
299-323 6.76e-06

C2H2-type zinc-finger domain;


:

Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 43.69  E-value: 6.76e-06
                           10        20
                   ....*....|....*....|....*
gi 568935430   299 YKCELCPYSSSQKTHLTRHMRTHSG 323
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-310 3.29e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 3.29e-05
                           10        20
                   ....*....|....*....|....*.
gi 568935430   285 NYVQHVRTHTGERPYKCELCPYSSSQ 310
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
266-409 1.09e-03

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935430  266 FPRKVYTCSKCNYFSDRKNNYVQHVRT--HTGE--RPYKC--ELCPYSSSQKTHLTRHMRTHSGEKPFKC--DQCNY--- 334
Cdd:COG5048   285 GFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSkfs 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935430  335 --VASNQHEVTRHARQVHNGPKPLNCPHCDYK-TADRSNFKKHVELHVN--PRQFNCPVCdYAASKKCNLQYHFKSKHPT 409
Cdd:COG5048   365 plLNNEPPQSLQQYKDLKNDKKSETLSNSCIRnFKRDSNLSLHIITHLSfrPYNCKNPPC-SKSFNRHYNLIPHKKIHTN 443
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
607-776 6.04e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 6.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935430  607 TEPSSGALAQVGVSPDPALIQAEVTGSGSSQTELPSPMDIAKSEPAQMEVSLTGP---PPVEPAQMEPSPAKPPQVEAPT 683
Cdd:PRK12323  396 APAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPapaPAAAPAAAARPAAAGPRPVAAA 475

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935430  684 YPQPPQRGPAPPTGPAPPTGP---APPTEPAPPTGLAEMEPSPTEPSQKEPPPSMEPPCPEELPQAEPPPMedcQKELPS 760
Cdd:PRK12323  476 AAAAPARAAPAAAPAPADDDPppwEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPA---AAPAPR 552

                         170
                  ....*....|....*.
gi 568935430  761 PVEPAQIEVAQTAPTQ 776
Cdd:PRK12323  553 AAAATEPVVAPRPPRA 568
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-338 6.10e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 6.10e-06
                           10        20
                   ....*....|....*....|....*.
gi 568935430   313 HLTRHMRTHSGEKPFKCDQCNYVASN 338
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
299-323 6.76e-06

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 43.69  E-value: 6.76e-06
                           10        20
                   ....*....|....*....|....*
gi 568935430   299 YKCELCPYSSSQKTHLTRHMRTHSG 323
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-310 3.29e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 3.29e-05
                           10        20
                   ....*....|....*....|....*.
gi 568935430   285 NYVQHVRTHTGERPYKCELCPYSSSQ 310
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
297-376 3.87e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 3.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935430  297 RPYKCELCPYSSSQKTHLTRHMRTHSGEKPFKC--DQCNYVASNQHEVTRHARQVHNGPKPLNC---PHCDYKTADRSNF 371
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslPLSNSKASSSSLS 111


                  ....*
gi 568935430  372 KKHVE 376
Cdd:COG5048   112 SSSSN 116
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
266-409 1.09e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935430  266 FPRKVYTCSKCNYFSDRKNNYVQHVRT--HTGE--RPYKC--ELCPYSSSQKTHLTRHMRTHSGEKPFKC--DQCNY--- 334
Cdd:COG5048   285 GFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSkfs 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935430  335 --VASNQHEVTRHARQVHNGPKPLNCPHCDYK-TADRSNFKKHVELHVN--PRQFNCPVCdYAASKKCNLQYHFKSKHPT 409
Cdd:COG5048   365 plLNNEPPQSLQQYKDLKNDKKSETLSNSCIRnFKRDSNLSLHIITHLSfrPYNCKNPPC-SKSFNRHYNLIPHKKIHTN 443
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
358-378 1.09e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 37.14  E-value: 1.09e-03
                           10        20
                   ....*....|....*....|.
gi 568935430   358 CPHCDYKTADRSNFKKHVELH 378
Cdd:pfam13909    3 CSQCDYSTAWKSNLKRHLRKH 23
ZnF_C2H2 smart00355
zinc finger;
299-321 2.54e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.29  E-value: 2.54e-03
                            10        20
                    ....*....|....*....|...
gi 568935430    299 YKCELCPYSSSQKTHLTRHMRTH 321
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
607-776 6.04e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 6.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935430  607 TEPSSGALAQVGVSPDPALIQAEVTGSGSSQTELPSPMDIAKSEPAQMEVSLTGP---PPVEPAQMEPSPAKPPQVEAPT 683
Cdd:PRK12323  396 APAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPapaPAAAPAAAARPAAAGPRPVAAA 475

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935430  684 YPQPPQRGPAPPTGPAPPTGP---APPTEPAPPTGLAEMEPSPTEPSQKEPPPSMEPPCPEELPQAEPPPMedcQKELPS 760
Cdd:PRK12323  476 AAAAPARAAPAAAPAPADDDPppwEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPA---AAPAPR 552

                         170
                  ....*....|....*.
gi 568935430  761 PVEPAQIEVAQTAPTQ 776
Cdd:PRK12323  553 AAAATEPVVAPRPPRA 568
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
313-338 6.10e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 6.10e-06
                           10        20
                   ....*....|....*....|....*.
gi 568935430   313 HLTRHMRTHSGEKPFKCDQCNYVASN 338
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
299-323 6.76e-06

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 43.69  E-value: 6.76e-06
                           10        20
                   ....*....|....*....|....*
gi 568935430   299 YKCELCPYSSSQKTHLTRHMRTHSG 323
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-310 3.29e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 3.29e-05
                           10        20
                   ....*....|....*....|....*.
gi 568935430   285 NYVQHVRTHTGERPYKCELCPYSSSQ 310
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 299-321 8.50e-05

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 40.36  E-value: 8.50e-05
                           10        20
                   ....*....|....*....|...
gi 568935430   299 YKCELCPYSSSQKTHLTRHMRTH 321
Cdd:pfam00096    1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
297-376 3.87e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 3.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935430  297 RPYKCELCPYSSSQKTHLTRHMRTHSGEKPFKC--DQCNYVASNQHEVTRHARQVHNGPKPLNC---PHCDYKTADRSNF 371
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslPLSNSKASSSSLS 111


                  ....*
gi 568935430  372 KKHVE 376
Cdd:COG5048   112 SSSSN 116
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
266-409 1.09e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935430  266 FPRKVYTCSKCNYFSDRKNNYVQHVRT--HTGE--RPYKC--ELCPYSSSQKTHLTRHMRTHSGEKPFKC--DQCNY--- 334
Cdd:COG5048   285 GFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSkfs 364

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935430  335 --VASNQHEVTRHARQVHNGPKPLNCPHCDYK-TADRSNFKKHVELHVN--PRQFNCPVCdYAASKKCNLQYHFKSKHPT 409
Cdd:COG5048   365 plLNNEPPQSLQQYKDLKNDKKSETLSNSCIRnFKRDSNLSLHIITHLSfrPYNCKNPPC-SKSFNRHYNLIPHKKIHTN 443
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
358-378 1.09e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 37.14  E-value: 1.09e-03
                           10        20
                   ....*....|....*....|.
gi 568935430   358 CPHCDYKTADRSNFKKHVELH 378
Cdd:pfam13909    3 CSQCDYSTAWKSNLKRHLRKH 23
zf-H2C2_5 pfam13909
C2H2-type zinc-finger domain;
271-295 1.79e-03

C2H2-type zinc-finger domain;


Pssm-ID: 404746 [Multi-domain]  Cd Length: 25  Bit Score: 36.76  E-value: 1.79e-03
                           10        20
                   ....*....|....*....|....*
gi 568935430   271 YTCSKCNYFSDRKNNYVQHVRTHTG 295
Cdd:pfam13909    1 YKCSQCDYSTAWKSNLKRHLRKHTG 25
ZnF_C2H2 smart00355
zinc finger;
299-321 2.54e-03

zinc finger;


Pssm-ID: 197676  Cd Length: 23  Bit Score: 36.29  E-value: 2.54e-03
                            10        20
                    ....*....|....*....|...
gi 568935430    299 YKCELCPYSSSQKTHLTRHMRTH 321
Cdd:smart00355    1 YRCPECGKVFKSKSALREHMRTH 23
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
607-776 6.04e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 6.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935430  607 TEPSSGALAQVGVSPDPALIQAEVTGSGSSQTELPSPMDIAKSEPAQMEVSLTGP---PPVEPAQMEPSPAKPPQVEAPT 683
Cdd:PRK12323  396 APAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPapaPAAAPAAAARPAAAGPRPVAAA 475

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935430  684 YPQPPQRGPAPPTGPAPPTGP---APPTEPAPPTGLAEMEPSPTEPSQKEPPPSMEPPCPEELPQAEPPPMedcQKELPS 760
Cdd:PRK12323  476 AAAAPARAAPAAAPAPADDDPppwEELPPEFASPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPA---AAPAPR 552

                         170
                  ....*....|....*.
gi 568935430  761 PVEPAQIEVAQTAPTQ 776
Cdd:PRK12323  553 AAAATEPVVAPRPPRA 568
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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