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Conserved domains on  [gi|568975606|ref|XP_006534176|]
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monocarboxylate transporter 13 isoform X1 [Mus musculus]

Protein Classification

monocarboxylate transporter( domain architecture ID 13024522)

proton-linked monocarboxylate transporter catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate; similar to monocarboxylate transporters MCT11 and MCT13

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MCT11_13 cd17423
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ...
 13-344 1.33e-149

Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340981 [Multi-domain]  Cd Length: 383  Bit Score: 427.96  E-value: 1.33e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGS------------------------- 67
Cdd:cd17423    1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASpvgsalstrygarpvvmlggllssl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  68 -----------------------SGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 124
Cdd:cd17423   81 gfllasfatsllhlylcigllsgLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 125 LLVSALSLHLMACGALLRPLSLTEDAAV---GGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPL 201
Cdd:cd17423  161 LLLSALSLHLVPCGALLRPLALPGDPPApprSLSAAFGLSLLTHRAFLRYALATTLINTGYFIPYVHLVAHARALGLGEY 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 202 PAAFLLSVAAVSDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVL 281
Cdd:cd17423  241 QAAFVVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAGALAPLVFSVL 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568975606 282 PELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLP 344
Cdd:cd17423  321 PELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSLILLTLP 383
 
Name Accession Description Interval E-value
MFS_MCT11_13 cd17423
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ...
 13-344 1.33e-149

Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340981 [Multi-domain]  Cd Length: 383  Bit Score: 427.96  E-value: 1.33e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGS------------------------- 67
Cdd:cd17423    1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASpvgsalstrygarpvvmlggllssl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  68 -----------------------SGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 124
Cdd:cd17423   81 gfllasfatsllhlylcigllsgLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 125 LLVSALSLHLMACGALLRPLSLTEDAAV---GGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPL 201
Cdd:cd17423  161 LLLSALSLHLVPCGALLRPLALPGDPPApprSLSAAFGLSLLTHRAFLRYALATTLINTGYFIPYVHLVAHARALGLGEY 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 202 PAAFLLSVAAVSDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVL 281
Cdd:cd17423  241 QAAFVVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAGALAPLVFSVL 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568975606 282 PELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLP 344
Cdd:cd17423  321 PELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSLILLTLP 383
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
 3-337 1.38e-46

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 164.91  E-value: 1.38e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606    3 RRAEPPDGGWGWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIA------------VQQFGSS-- 68
Cdd:TIGR00892   7 PEGPPPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAvlyaggpissilVNRFGCRpv 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606   69 ----------------------------------GWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWL 114
Cdd:TIGR00892  87 viaggllaslgmilasfssnvielyltagfitglGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  115 INNYAWRGALLLVSALSLHLMACGALLRPL--------SLTEDAAVGGPGAQIT---------------SLLRHGPFLRY 171
Cdd:TIGR00892 167 FESFGWRGSFLILGGLLLHCCVCGALMRPVgpsqrvskSKSKEGLPPDGSTKKLskkstaekinrfldfSLFTHRGFLVY 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  172 TAALTLINTGFFIPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGD--AVPGPVARLLMLWTTLTGVSLAL 249
Cdd:TIGR00892 247 LSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGlkWIRPHVQYLFSFALLFNGLTHLL 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  250 FPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVA 329
Cdd:TIGR00892 327 CALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYAS 406


                  ....*...
gi 568975606  330 GAFLLAGS 337
Cdd:TIGR00892 407 GSIVVSAG 414
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
69-343 7.51e-24

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 101.49  E-value: 7.51e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  69 GWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGALLLVSALSLHLMACGALLRPlSLTE 148
Cdd:COG2807  119 GIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLR-RRPA 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 149 DAAVGGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAV 228
Cdd:COG2807  198 AAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRL 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 229 PGPvARLLMLWTTLTGVSLALFPVAQASSTLVVlAVAYGFTSGALTPVAFSVLPELVGTGRIYC-GMGLVQMIESIGGLL 307
Cdd:COG2807  278 GDR-RPLLLLLGLLGLAGLLGLLLAPGSLPWLW-AVLLGLGQGGLFPLALTLIGLRARTPAEAAaLSGMAQSVGYLLAAL 355

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568975606 308 GAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTL 343
Cdd:COG2807  356 GPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
MFS_1 pfam07690
Major Facilitator Superfamily;
71-309 7.00e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 62.82  E-value: 7.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606   71 ALTFTPTMACLSRYFS-QRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGALLLVSALSLHLMACGALLRP----LS 145
Cdd:pfam07690 100 GALFPAALALIADWFPpEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPppesKR 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  146 LTEDAAVGGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLG 225
Cdd:pfam07690 180 PKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLS 259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  226 D-AVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIG 304
Cdd:pfam07690 260 DrLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLG 339


                  ....*
gi 568975606  305 GLLGA 309
Cdd:pfam07690 340 GALGP 344
 
Name Accession Description Interval E-value
MFS_MCT11_13 cd17423
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ...
 13-344 1.33e-149

Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340981 [Multi-domain]  Cd Length: 383  Bit Score: 427.96  E-value: 1.33e-149
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGS------------------------- 67
Cdd:cd17423    1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVQQLASpvgsalstrygarpvvmlggllssl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  68 -----------------------SGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 124
Cdd:cd17423   81 gfllasfatsllhlylcigllsgLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 125 LLVSALSLHLMACGALLRPLSLTEDAAV---GGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPL 201
Cdd:cd17423  161 LLLSALSLHLVPCGALLRPLALPGDPPApprSLSAAFGLSLLTHRAFLRYALATTLINTGYFIPYVHLVAHARALGLGEY 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 202 PAAFLLSVAAVSDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVL 281
Cdd:cd17423  241 QAAFVVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAGALAPLVFSVL 320

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568975606 282 PELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLP 344
Cdd:cd17423  321 PELVGVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSLILLTLP 383
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 13-344 1.53e-70

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 225.12  E-value: 1.53e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSS------------------------ 68
Cdd:cd17352    1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPlssalvnrfgcrpvaiaggllaal 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  69 ------------------------GWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 124
Cdd:cd17352   81 glllssfatslwqlyltygvlgglGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 125 LLVSALSLHLMACGALLRplsltedaavggpgaqitsLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAA 204
Cdd:cd17352  161 LILGGLCLNLCVCGLLLR-------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAA 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 205 FLLSVAAVSDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPEL 284
Cdd:cd17352  222 FLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADL 301

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 285 VGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLP 344
Cdd:cd17352  302 VGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLLFLLP 361
MFS_MCT7 cd17422
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ...
 13-343 1.31e-55

Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340980 [Multi-domain]  Cd Length: 363  Bit Score: 186.49  E-value: 1.31e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAVQQFGSS------------------------ 68
Cdd:cd17422    1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPlstvlsnrfghrpvvmvggllisl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  69 ------------------------GWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 124
Cdd:cd17422   81 gmitasfassivemyltigiisglGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 125 LLVSALSLHLMACGALLRplsltedaavggpgaqitsLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAA 204
Cdd:cd17422  161 LVVGALQLNIVVCGALLR-------------------VLKEPGFICYALFGLFATLGFFAPQLYIIPLSLSLGIDQDWAA 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 205 FLLSVAAVSDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPE- 283
Cdd:cd17422  222 YMLSAMAIAELFGRISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVAGTHIPLLAEd 301

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568975606 284 -LVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGsGVLLTL 343
Cdd:cd17422  302 dVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALG-AVFLAL 361
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
 3-337 1.38e-46

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 164.91  E-value: 1.38e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606    3 RRAEPPDGGWGWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIA------------VQQFGSS-- 68
Cdd:TIGR00892   7 PEGPPPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAvlyaggpissilVNRFGCRpv 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606   69 ----------------------------------GWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWL 114
Cdd:TIGR00892  87 viaggllaslgmilasfssnvielyltagfitglGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYL 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  115 INNYAWRGALLLVSALSLHLMACGALLRPL--------SLTEDAAVGGPGAQIT---------------SLLRHGPFLRY 171
Cdd:TIGR00892 167 FESFGWRGSFLILGGLLLHCCVCGALMRPVgpsqrvskSKSKEGLPPDGSTKKLskkstaekinrfldfSLFTHRGFLVY 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  172 TAALTLINTGFFIPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGD--AVPGPVARLLMLWTTLTGVSLAL 249
Cdd:TIGR00892 247 LSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGlkWIRPHVQYLFSFALLFNGLTHLL 326

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  250 FPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVA 329
Cdd:TIGR00892 327 CALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYAS 406


                  ....*...
gi 568975606  330 GAFLLAGS 337
Cdd:TIGR00892 407 GSIVVSAG 414
MFS_MCT12 cd17424
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ...
 13-340 7.64e-37

Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340982 [Multi-domain]  Cd Length: 363  Bit Score: 136.86  E-value: 7.64e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWI----------------------------------ASI 58
Cdd:cd17424    1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIhsivdcttmlcaplgslisnhlscqvgiilggllAST 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  59 GIAVQQFGSS--------------GWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 124
Cdd:cd17424   81 GLILSSFATSleylyltlgvltglGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 125 LLVSALSLHLMACGALLRPLsLTEDaavggpgaqitsllrhgpFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAA 204
Cdd:cd17424  161 LILGGFVLNLCVCGALMRFL-LMPD------------------FLVLAVSVLFLAYGCSPPFVYLVPYALSVGVSHQQAA 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 205 FLLSVAAVSDLVGRVASGWLGDAVPGPVARLL--MLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLP 282
Cdd:cd17424  222 FLMSILGVIDIIGNITFGWLTDRRCLKKYRYFcyLFAVGMDGLCCLFLPILKTFPLLVPFSFTFGYFDGAYVALIPVVTS 301

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568975606 283 ELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVL 340
Cdd:cd17424  302 DVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLL 359
MFS_MCT5 cd17421
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ...
 13-344 7.53e-36

Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340979 [Multi-domain]  Cd Length: 369  Bit Score: 134.18  E-value: 7.53e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASI---------------------------------- 58
Cdd:cd17421    1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSImsslrlsagplasvacgrlgerwtsilgaflvsa 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  59 GIAVQQFGSS--------------GWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISsFAFAPLFQWLINNYAWRGAL 124
Cdd:cd17421   81 GFLISIFATSvpflyvsmgllvglGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLT-FALAPFTQLLLDEYDWQGAL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 125 LLVSALSLHLMACGALLRPLSLtedaavggpgaqitSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAA 204
Cdd:cd17421  160 LIFGGIMLNLVASGMLLRPIDF--------------SLLKDPFFCIYTWSFVFSQLAYFIPYFHLVARARTLGIDPMDAS 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 205 FLLSVAAVSDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPEL 284
Cdd:cd17421  226 FIISVAGITETVAQLASGWIADQNWIKKYHYHKAYLILCGVTNLLAPLATTYPLLMTYAVFFAIFCGGYLALLLPVLVDL 305

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 285 VGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLP 344
Cdd:cd17421  306 VGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGGCYLLSSVSFFLEP 365
MFS_MCT2 cd17427
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ...
 13-337 1.11e-34

Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340985 [Multi-domain]  Cd Length: 367  Bit Score: 131.09  E-value: 1.11e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAV------------QQFGSS------------ 68
Cdd:cd17427    1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVmyaggpissilvNKYGSRpvviaggllcsl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  69 ------------------------GWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 124
Cdd:cd17427   81 gmisasfcnsvmqlylcigvigglGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 125 LLVSALSLHLMACGALLRPLsltedaavgGPgaqitsLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAA 204
Cdd:cd17427  161 LILGGLLLNCCVAGSLMRPL---------GP------LFKHRGFLIYLSGNVIMFLGFFAPIVFLAPYAKHMGIDEYSAA 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 205 FLLSVAAVSDLVGRVASGWLGDA--VPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLP 282
Cdd:cd17427  226 FLLSILAFVDMFARPSMGLVANSkwIRPRIQYFFSFAVMYNGVCHLLCPLAEDYTGLVIYAVFFGFAFGMVSSVLFETLM 305

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568975606 283 ELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGS 337
Cdd:cd17427  306 DLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVAS 360
MFS_MCT3_4 cd17430
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ...
 13-343 2.85e-34

Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340988 [Multi-domain]  Cd Length: 368  Bit Score: 130.23  E-value: 2.85e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASI------------GIAVQQFGSS------------ 68
Cdd:cd17430    1 GWAVLFGCFVITGFSYAFPKAVSVFFKELMREFGVGYSDTAWISSIllamlygtgplcSILVNRFGCRpvmlvggllasl 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  69 ------------------------GWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 124
Cdd:cd17430   81 gmilasfctsiiqlyltagvitglGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 125 LLVSALSLHLMACGALLRPLSLtedaavggpgaqitSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAA 204
Cdd:cd17430  161 LILGGLLLNCCTCGAVMRPLDF--------------SVFRDRGFVIYTIAKFIMVLGLFVPPIFVVNYAKDIGVPDTEAA 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 205 FLLSVAAVSDLVGRVASG------WLGDAVPGPVArLLMLWTTLTGVSLAlfpVAQASSTLVVLAVAYGFTSGALTPVAF 278
Cdd:cd17430  227 FLLSILGFIDIFARPACGvvaglkWVRPRVVYLFS-FAMLFNGLTDLCSA---TAADYGGLVVFCVFFGISYGMVGALQF 302

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568975606 279 SVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAgSGVLLTL 343
Cdd:cd17430  303 EVLMAIVGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVL-SALFLAL 366
MFS_MCT1 cd17426
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ...
 13-337 7.23e-31

Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340984 [Multi-domain]  Cd Length: 374  Bit Score: 120.75  E-value: 7.23e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASIGIAV------------QQFGSS------------ 68
Cdd:cd17426    1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVmyaggpissilvNKYGSRpimiaggclsga 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  69 ------------------------GWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 124
Cdd:cd17426   81 gliaasfcntveglyfcvgvvgglGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 125 LLVSALSLHLMACGALLRPLsltedaavgGPGAQIT-SLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPA 203
Cdd:cd17426  161 LILGGLLLNCCVAGSLMRPI---------GPKPFLDlTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSNYAKSKQISNESA 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 204 AFLLSVAAVSDLVGRVASGWLGDA--VPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVL 281
Cdd:cd17426  232 AFLLSILAFVDMVARPSMGIVANTkwVRPRIQYFFAASVLYNGVCHLLAPLSTSYVGFCIYAIFFGFAFGWLSSVLFETL 311

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 568975606 282 PELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGS 337
Cdd:cd17426  312 MDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISS 367
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 53-343 9.00e-26

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 106.97  E-value: 9.00e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  53 SWIASIGIAVQQFGSSGwALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGALLLVSALSL 132
Cdd:cd17355   91 LWQLYLLWGLLGGGGAG-TLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLAL 169

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 133 HLMACGALLR-------PLSLTEDAAVGGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAAF 205
Cdd:cd17355  170 LVLVPVLLLLrrrpadlALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAV 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 206 LLSVAAVSDLVGRVASGWLGDAVPGPvaRLLMLWTTLTGVSLALFPVAQASSTLVVLAVA-YGFTSGALTPVAFSVLPEL 284
Cdd:cd17355  250 ALALIGLFNIVGRLLSGWLGDRYSPR--RLLAASYALRALGLALLLLLPFPPLALLLFAAlFGLGWGATVPLTAALAARY 327

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568975606 285 VGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTL 343
Cdd:cd17355  328 FGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
69-343 7.51e-24

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 101.49  E-value: 7.51e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  69 GWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGALLLVSALSLHLMACGALLRPlSLTE 148
Cdd:COG2807  119 GIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLR-RRPA 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 149 DAAVGGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAV 228
Cdd:COG2807  198 AAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRL 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 229 PGPvARLLMLWTTLTGVSLALFPVAQASSTLVVlAVAYGFTSGALTPVAFSVLPELVGTGRIYC-GMGLVQMIESIGGLL 307
Cdd:COG2807  278 GDR-RPLLLLLGLLGLAGLLGLLLAPGSLPWLW-AVLLGLGQGGLFPLALTLIGLRARTPAEAAaLSGMAQSVGYLLAAL 355

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568975606 308 GAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTL 343
Cdd:COG2807  356 GPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
MFS_MCT14 cd17429
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ...
 13-344 1.41e-22

Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340987 [Multi-domain]  Cd Length: 361  Bit Score: 97.59  E-value: 1.41e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIAS------------IGIAVQQFG------------SS 68
Cdd:cd17429    1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSlsmgitlivgpfIGLFINTCGcrktaiiggiltSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  69 GWALT------------------------FTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 124
Cdd:cd17429   81 GWVLSayatnvhylfisfgvtagigsgmaYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAM 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 125 LLVSALSLHLMACGALLRplsltedaavggpgaqitsLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAA 204
Cdd:cd17429  161 FIQGAVSLNLCVCGALMR-------------------LFTNKVFVAFIFWALFAYCSFVIPFIHLPEIVKLYGLSEQNDK 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 205 F-LLSVAAVSDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSG--ALTPVafsVL 281
Cdd:cd17429  222 FpLTSIIAIVHIFGKVILGIICDLPCISVWNVFILANFTLGVCILILPLMHTYTGLAIVCALIGFSSGyfSLMPV---VT 298

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568975606 282 PELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLP 344
Cdd:cd17429  299 EDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYVCGLLYMVGIICLLLKP 361
MFS_MCT6 cd17425
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ...
 13-343 2.73e-22

Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340983 [Multi-domain]  Cd Length: 364  Bit Score: 96.76  E-value: 2.73e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASI------------GIAVQQFG-------------- 66
Cdd:cd17425    1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSImtavlhaggplcSILVERFGcrvtvmlggllsgv 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  67 ----SS------------------GWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 124
Cdd:cd17425   81 gmvaSSfshsivqlyftagfitglGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSF 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 125 LLVSALSLHLMACGALLRPlsltedaavggpgaqitsLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAA 204
Cdd:cd17425  161 LVFGGVLLNCCVCGAVMRP------------------FCSNTRYQIYTLGVTWMVLGFVLPLIYLVPYATSNGMDESKAA 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 205 FLLSVAAVSDLVGRVASGWLGD--AVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLP 282
Cdd:cd17425  223 LLLSILGFINIFMRPLAGLLSGlpVFKGRRIYLFSLALLLNGLSNLICAISASFPVLLVYCLLYSISMSGIGSLIFQVLM 302

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568975606 283 ELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFvVAGAFLLAGSGVLLTL 343
Cdd:cd17425  303 DTVEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVF-YASSIFVVSAALFMGL 362
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
71-344 3.37e-21

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 93.79  E-value: 3.37e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  71 ALTFTPTMACLSRYF-SQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGALLLVSALSLHLMACGAL-LRPLSLTE 148
Cdd:COG2223  108 GGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLfLRDPPAGA 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 149 DAAVGGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQD-LGWDPLPAAFLLSVAAVSDLVGRVASGWLGDA 227
Cdd:COG2223  188 AAAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDqFGLSAATAGLLAALFALLGALGRPLGGWLSDR 267

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 228 VPGpvARLLMLWTTLTGVSLALFPVAQASSTL-VVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGL 306
Cdd:COG2223  268 IGG--RRVLLIVFALMALGLLLLALALGSLWLfLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGF 345

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 568975606 307 LGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLP 344
Cdd:COG2223  346 LGPLLFGALLDATGSYTAAFLVFAVLALVALVLTLLLY 383
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
71-344 8.50e-18

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 83.77  E-value: 8.50e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  71 ALTFTPTMACLSRYFS-QRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGALllvsalslhlmacgallrplslted 149
Cdd:COG2271  113 AGFFPAALKLIAEWFPpKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF------------------------- 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 150 AAVGGPGAqITSLLRhgpFLRYTAALTLINTGFFIPYVHLVAHLQD-LGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAV 228
Cdd:COG2271  168 LILGLPGL-LLALLR---FWLLALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRL 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 229 PGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLG 308
Cdd:COG2271  244 GRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALG 323

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 568975606 309 APLSGYLRDVTGnYTASFVVAGAFLLAGSGVLLTLP 344
Cdd:COG2271  324 PLLVGYLLDATG-YQAAFLLLAALALLAALLALLLL 358
MFS_MCT8_10 cd17420
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ...
 13-344 1.14e-17

Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340978 [Multi-domain]  Cd Length: 400  Bit Score: 83.73  E-value: 1.14e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAF-----EEQAARVSWIAS------------------------------ 57
Cdd:cd17420    1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLtklgdPEASFKAAWVGAlamgmiffcspivscftdkigcrltafaga 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  58 ----IGIAVQQFGSS--------------GWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYA 119
Cdd:cd17420   81 avsfGGLLLSSFCSSigalyftygimfgcGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 120 WRGALLLVSALSLHLMACGALLRPLSLTEDAAVGGPGAQITS--------------LLRHGPFLRYTAALTLINTGFFIP 185
Cdd:cd17420  161 LEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSKPGRRTLHsrinlflrkifnveIFKRKRYVIWALGIPLALFGYFVP 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 186 YVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPGpVAR--LLMLWTTLTGVSLALFPVAQASSTLVVLA 263
Cdd:cd17420  241 YVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPPG-VKKmyLQVLSFVSIGLMSMMIPLCNSFGILISVC 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 264 VAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTL 343
Cdd:cd17420  320 LVMGLFDGCFISIMAPIAFELVGPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIGSSLLFFI 399


                 .
gi 568975606 344 P 344
Cdd:cd17420  400 P 400
MFS_MCT9 cd17428
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ...
 13-341 1.64e-15

Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340986 [Multi-domain]  Cd Length: 361  Bit Score: 77.16  E-value: 1.64e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASI------------GIAVQQFGSS------------ 68
Cdd:cd17428    1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLasgvgliaspvcSACVSSFGARpvtifsgfmvag 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  69 ------------------------GWALTFTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 124
Cdd:cd17428   81 glmlsafapniyflifsygivvglGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 125 LLVSALSLHLMACGALLRplsltedaavggpgaqitsLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAA 204
Cdd:cd17428  161 LIVGALALNLLACGSLMR-------------------LFKNRVFSALFIAILLFDIGAFPPSLLMEDVARSENIIEEIAL 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 205 F-LLSVAAVSDLVGRVASGWLGDAVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFsVLPE 283
Cdd:cd17428  222 IpLVSIIGITTAIGKLILGVLADFKWVNSLYLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGFLSGNWSIFPY-VTTK 300

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568975606 284 LVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLL 341
Cdd:cd17428  301 TVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLLL 358
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 13-341 2.35e-14

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 73.60  E-value: 2.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAARVSWIASI------------GIAVQQFG------------SS 68
Cdd:cd17314    1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLsnlgmlltqpilGFIADSFGprplmalagimvLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  69 GWALT------------------------FTPTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGAL 124
Cdd:cd17314   81 GYTYLsyvfnsfplsyacfvfigagtgilYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 125 LLVSALSLHLMACGALLRPLS----LTEDAAVGGPGAQITSLLRHGPFLRYTAALTLINTGFFIP---YVHLVAHLQDLG 197
Cdd:cd17314  161 TILGILAAIVLSVVSLLGFKEppdnQARLHVQKKKTQTMGEIFRDKVFWILFIAIFLVLIGGFLFianMASLVRSLQLDA 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 198 WDPLPAafLLSVAAVSDLVGRVASGWLGDAVPGpvaRLLMLWTTLT--GVSLALFPVAQAS--STLVVLAVAYGFTSGAL 273
Cdd:cd17314  241 PSFVTK--LMSIYGLFNAFGRLLWGIVADFFGG---RLSTLSILLTilGLGLCAFLFLLKMtpVGLVLTGSLLGFSYGGL 315

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568975606 274 TPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLL 341
Cdd:cd17314  316 FTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILL 383
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 87-341 4.31e-14

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 73.04  E-value: 4.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  87 QRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWR-GALLLVSALSLHLMACGALLR--PLSLTEDAAVGGPGAQITSLL 163
Cdd:cd17475  116 RERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRaAFVVAGLVSILAAVLFWLFYRepPAASAATESASTLLRSLKEVL 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 164 RHGPFLRYTAALTLINTGFFIPYVHLVAHLQD-LGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPG----PVARLLML 238
Cdd:cd17475  196 RNRDVWLIAIAGALLVAPQFALLTFLLLFLHDhLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGgrrrPVLVITAA 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 239 WTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDV 318
Cdd:cd17475  276 IAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDA 355

                        250       260
                 ....*....|....*....|...
gi 568975606 319 TGNYTASFVVAGAFLLAGSGVLL 341
Cdd:cd17475  356 THSYAPAWLALALLLVLAALLLL 378
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
69-305 8.70e-13

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 68.85  E-value: 8.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  69 GWALTFTPTMACLSRYFS-QRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGALLLVSALSLHLMACGALLRPLSLT 147
Cdd:COG2814  111 GAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRP 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 148 EDAAvgGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQD-LGWDPLPAAFLLSVAAVSDLVGRVASGWLGD 226
Cdd:COG2814  191 AARA--RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLAD 268

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568975606 227 AVPGpvARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGG 305
Cdd:COG2814  269 RFGR--RRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 24-343 1.06e-12

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 68.79  E-value: 1.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  24 SALVFGVLRSFGVFFVEFVAAFeeqaarvsWIASIGIAVqqFGSSGWALTFTPTMACLSRYFSQRRSLAMGLALTGVGIS 103
Cdd:cd17353   70 AILIGGILFGLGFILSAFAISL--------PLLFLGYGV--LGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLG 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 104 SFAFAPLFQWLINNYAWRGALLLVSALSLHLMACGALL-----------RPLSLTEDAAVGGPGAQITSLLRHGPFLRYT 172
Cdd:cd17353  140 SLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLirdppkgwvppGVDPLANNAENSPRDYTPREMLRTPTFWLLW 219

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 173 AALTLINTG--FFIPYVHLVAHlQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVpGPVaRLLMLWTTLTGVSLALF 250
Cdd:cd17353  220 LMFFLNATAglMLIGQAKPIGQ-EFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKI-GRK-NTLSIAFLIQGVAMFLL 296

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 251 PVAQASSTLVVLAVA-YGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLrDVTGNYTASFVVA 329
Cdd:cd17353  297 PFIGSVAVLFVLGVAlIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYV-LYTGGYNAAFIIA 375

                        330
                 ....*....|....
gi 568975606 330 GAFLLAGSGVLLTL 343
Cdd:cd17353  376 AALSLVALALALLL 389
MFS_MCT8 cd17465
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ...
 13-344 9.03e-12

Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341023 [Multi-domain]  Cd Length: 367  Bit Score: 65.59  E-value: 9.03e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAFEEQAAR-----VSWIASIGIAVQQFGSsgwaltftPTMACLSRYFSQ 87
Cdd:cd17465    1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLNEQEDQKDQavqfkTAWVGALAMGMIFFCS--------PVVSIFTDRFGC 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  88 RRSLAMGLALTGVGI-----------------------SSFAFAPLFQWLINNYAWRGALLLVSALSLHLMACGALLRPL 144
Cdd:cd17465   73 RKTAMGGAAVAFIGLlsssftkslglryftygilfgcgSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLL 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 145 SLTEDAAVGGPGAQITSLL--------------RHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAAFLLSVA 210
Cdd:cd17465  153 KMVGDAIGLAHTFQVLSLFmfiqiflsltykvfRRKTYRIWAFGIATAVLGYFVPYVHLMKYVEEEFKENKREWVLLVCI 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 211 AVSDLVGRVASGWLGDAVPGPVA-RLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGR 289
Cdd:cd17465  233 GASSGIGRLMSGKIGDLIPGLKKiYLQVASFLLLGIMSMMIPLCQVFEGVIVVCLFLGLCDGCFITIMAPIAFELVGPMQ 312

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568975606 290 IYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLP 344
Cdd:cd17465  313 ASQAIGYLLGLMAIPMTAGPPIAGLLHDYFGSYHVAFYLAGVPPIIGGTVLFFVP 367
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 69-341 2.40e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 64.52  E-value: 2.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  69 GWALTFTPTMACLSRYF-SQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGALLLVSALSLHLMACGALLRPLSLT 147
Cdd:cd17325   97 ASAAVWPAAMALIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRP 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 148 EDAAVGGPGAQITS---LLRHGPFLRYTAALTLIN---TGFFIPYVHLVAHlQDLGWDPLPAAFLLSVAAVSDLVGRVAS 221
Cdd:cd17325  177 PPNKRAVSAARLRSglrLLLRDRRLLALFLAIFVLafaFGALEPFLPLYAA-ELGGLSPAQIGLLFGAQGLASALSQPPA 255

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 222 GWLGDAVPGPvaRLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIE 301
Cdd:cd17325  256 GKLSDRIGRK--PLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAF 333

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 568975606 302 SIGGLLGAPLSGYLRDVTGnYTASFVVAGAFLLAGSGVLL 341
Cdd:cd17325  334 SLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFL 372
MFS_1 pfam07690
Major Facilitator Superfamily;
71-309 7.00e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 62.82  E-value: 7.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606   71 ALTFTPTMACLSRYFS-QRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGALLLVSALSLHLMACGALLRP----LS 145
Cdd:pfam07690 100 GALFPAALALIADWFPpEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPppesKR 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  146 LTEDAAVGGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLG 225
Cdd:pfam07690 180 PKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLS 259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  226 D-AVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIG 304
Cdd:pfam07690 260 DrLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLG 339


                  ....*
gi 568975606  305 GLLGA 309
Cdd:pfam07690 340 GALGP 344
MFS_MCT10 cd17464
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ...
 13-344 8.01e-11

Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341022 [Multi-domain]  Cd Length: 395  Bit Score: 62.89  E-value: 8.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  13 GWMVVLSAFFQSALVFGVLRSFGVFFVEFVAAF-----EEQAARVSWIAS------------------------------ 57
Cdd:cd17464    1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLLEEFgskddAQMRFKTAWVGSlsmgmiffcspivsvftdlfgcrktatgga 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  58 ----IGIAVQQFGSSGWALTFT--------------PTMACLSRYFSQRRSLAMGLALTGVGISSFAFAPLFQWLINNYA 119
Cdd:cd17464   81 avgfVGLLASSFVSSIEPLYFTygiifacgcsfayqPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 120 WRGALLLVSALSLHLMACGALLRPLSLTEDAAVGG-------PGAQI--TSLLRHGPFLRYTAALTLINTGFFIPYVHLV 190
Cdd:cd17464  161 LFNTLRVLCIFMFVLFLAGFTYKPLVPMKKDKEGKkrkfkcpPLKKIfnFNIWKSTGYRIWAFGIPAALFGYFVPYVHLM 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 191 AHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPGPVARLLMLWT-TLTGVSLALFPVAQASSTLVVLAVAYGFT 269
Cdd:cd17464  241 NHVKERFGEDVNKEVLLMCIGITSGIGRLIFGRVADYIPGVKKVYLQVSSfFFIGLMSMMIPLCHVFGGLIAVCLFMGLF 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568975606 270 SGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLP 344
Cdd:cd17464  321 DGCFISIMAPIAFELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGVPPIIGGIILCFIP 395
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 172-345 9.71e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 59.51  E-value: 9.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 172 TAALTLINTGFFIPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPgpvARLLMLW-TTLTGVSLALF 250
Cdd:cd17325    2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFG---RKRLLLLgLLLLAVSTLLF 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 251 PVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGnYTASFVVAG 330
Cdd:cd17325   79 AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCA 157

                        170
                 ....*....|....*
gi 568975606 331 AFLLAGSGVLLTLPH 345
Cdd:cd17325  158 ALALLALVLALLLLP 172
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 194-343 2.24e-09

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 58.35  E-value: 2.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 194 QDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPGPVARL-LMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGA 272
Cdd:cd17319  208 QARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLvIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGA 287

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568975606 273 LTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTL 343
Cdd:cd17319  288 ASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLVLLL 358
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
160-344 3.21e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 57.68  E-value: 3.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 160 TSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPgpVARLLMLW 239
Cdd:COG2814    4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFG--RRRVLLLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 240 TTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVT 319
Cdd:COG2814   82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161

                        170       180
                 ....*....|....*....|....*
gi 568975606 320 GNYTASFVVAGAFLLAGSGVLLTLP 344
Cdd:COG2814  162 GWRWVFLVNAVLALLALLLLLRLLP 186
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 54-341 6.53e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 50.89  E-value: 6.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  54 WIASIGIAVQQFGSsgwALTFTPTMACLSRYFSQR-RSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGALLLVSALSL 132
Cdd:cd06174   85 WLLLLGRFLLGLGS---GLIDPAVLALIADLFPEReRGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAAL 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 133 HLMACGALLRPLSLTEDAAVGGPGAQ--------ITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQD-LGWDPLPA 203
Cdd:cd06174  162 ALLAAILLLLVVPDPPESARAKNEEAssksvlklLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDlGGLSVAVA 241

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 204 AFLLSVAAVSDLVGRVASGWLGDaVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPE 283
Cdd:cd06174  242 GLLLSLFGLAGALGSLLLGLLSD-RLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAE 320

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568975606 284 LVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLL 341
Cdd:cd06174  321 LFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 203-345 6.84e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 50.63  E-value: 6.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 203 AAFLLSVAAVSDLVGRVASGWLGDAVPGpvARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLP 282
Cdd:cd17324   36 AGLLVSAYALGYALGALLLGPLSDRIER--RRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAA 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568975606 283 ELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLPH 345
Cdd:cd17324  114 DLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPS 176
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 147-344 8.72e-07

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 50.26  E-value: 8.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 147 TEDAAVGGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGW-DPLPAAFLLSVAAVSDLVGRVASGWLG 225
Cdd:cd17473  178 RKSKSAASPGAATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGgSAALIGLALAIASLAGAIGALLFGRLK 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 226 DAVPgpVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGG 305
Cdd:cd17473  258 RRLG--KRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQ 335

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 568975606 306 LLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLP 344
Cdd:cd17473  336 FLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 88-336 1.41e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 49.86  E-value: 1.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  88 RRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGALLLVSALSLHLMACGALLRPLSLTEDAAVGGPGAQITSLLRHGP 167
Cdd:cd17324  120 KRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNPR 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 168 FLRYTAALTLINTGFFIPYVHLVAHLQDLGW-DPLPAAFLLSVAAVSDLVGRVASGWLGDAvpGPVARLLMLWTTLTGVS 246
Cdd:cd17324  200 LRLAYLITFLLFGGFFALYTYLAPFLTDVPGfSSSAIIGLLLLFGVAGVVGSPLAGRLADR--GGRRALLIALLLLAAAL 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 247 LALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRiYCGMGLVQMIESIGGLLGAPLSGYLRDVTGnYTASF 326
Cdd:cd17324  278 LLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEAR-GLASSLYLAAYNLGGALGAALGGLVLDHGG-WAGVG 355

                        250
                 ....*....|
gi 568975606 327 VVAGAFLLAG 336
Cdd:cd17324  356 WVGAALLLLA 365
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
90-352 1.48e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 49.90  E-value: 1.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  90 SLAMGLALTGVGISSFAFAPLFQWLINNYA--WRGALLLVSALSLHLMACGALLRPLSLTEDAAVGGPGAQITSLLRHGP 167
Cdd:COG2211  150 SWRFAFAGLGGLLASVLPPPLVAAFGGDAAlgYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKESLKALLKNRP 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 168 FLRYTAALTLINTGFFIPYVHLVAHLQD-LGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVpGPVaRLLMLWTTLTGVS 246
Cdd:COG2211  230 FLLLLLAYLLFFLALALVAALLLYYFKYvLGLSAALVGLLLALYFLAALLGAPLWPRLAKRF-GKK-KAFIIGLLLAALG 307

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 247 LALFPVAQASST--LVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCG-------MGLVQMIESIGGLLGAPLSGYLRD 317
Cdd:COG2211  308 LLLLFFLGPGNLwlLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGrrreglyFGIFTFAIKLGQALAGALAGLLLA 387

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 568975606 318 VTGnYTASFVVAGAFLLAGSGVLLTLPHFFSCISV 352
Cdd:COG2211  388 LFG-YVAGAAQSPSALTGIRLLFFLLPAVLLLLAA 421
MFS_1 pfam07690
Major Facilitator Superfamily;
194-345 2.09e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.95  E-value: 2.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  194 QDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPgpVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGAL 273
Cdd:pfam07690  25 EDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG--RRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGAL 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568975606  274 TPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLPH 345
Cdd:pfam07690 103 FPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPP 174
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 177-344 4.63e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 47.97  E-value: 4.63e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 177 LINTGFFIPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVpGPVaRLLMLWTTLTGVSLALFPVAQAS 256
Cdd:cd17489    7 FFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRF-GRK-RLLLIGLLIFALATLLYLLATSV 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 257 STLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGnYTASFVVAGAFLLAG 336
Cdd:cd17489   85 ALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG-FAVLFIVAAVLALLA 163


                 ....*...
gi 568975606 337 SGVLLTLP 344
Cdd:cd17489  164 LLLVFLVK 171
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 71-341 1.73e-05

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 46.53  E-value: 1.73e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  71 ALTFTPTMA-CLSRYFSQRRSLAMGLALTGVGISSF---AFAPLFQWLINNY--AWRGALLLVSalslhlmACGALLRPL 144
Cdd:cd06180  102 AFVFVFGSNlVLHHATAAGRGHLIGLLFAGVGLGIAlsgLLVPAGLGGGLSWraGWLALALLSA-------VLLLLSFLL 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 145 SLTEDAAVGGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWL 224
Cdd:cd06180  175 LRRGPSAPTEASAAESAPGLNRPLWRLALAYGLFGFGYIITATFLPLIARETGAGSLLAGLLWSLFGLAAVPSCFLWGAL 254

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 225 GDAVPGPVARLLMLWTTLTGVSLALfpVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCgMGLVQMIESIG 304
Cdd:cd06180  255 SDRWGTRRALAANLLVQAVGVLLPL--LSPGPAGLVLSAVLFGGTFMAITALVMALARELAPPAAPRA-LALMTASFGVG 331

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 568975606 305 GLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLL 341
Cdd:cd06180  332 QILGPLLAGWLADATGGFAPALILAAAALVVAALLAL 368
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 174-347 4.51e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 44.91  E-value: 4.51e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 174 ALTLINTGFFIPYVHLVAHlQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPGpvaRLLMLW-TTLTGVSLALFPV 252
Cdd:cd17329    9 FLNRLGFFMVWPFMAIYLH-QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGR---KPVMLAgLLLRALGFALLGF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 253 AQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLrdVTGNYTASFVV-AGA 331
Cdd:cd17329   85 AHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLL--LLYSFRLLFLAaAVL 162

                        170
                 ....*....|....*.
gi 568975606 332 FLLAGSGVLLTLPHFF 347
Cdd:cd17329  163 FLLAALVLLFLLPETR 178
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
143-335 6.85e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 44.46  E-value: 6.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 143 PLSLTEDAAVGGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQD-LGWDPLPAAFLLSVAAVSDLVGRVAS 221
Cdd:COG0738  187 PEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDvLGLSEATAALGLSLFWGGMTIGRFLG 266

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 222 GWLGDAVPGpvARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYcGMGLVQMIE 301
Cdd:COG0738  267 GFLLKRFGP--VRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAA-AVSAVLIMG 343

                        170       180       190
                 ....*....|....*....|....*....|....
gi 568975606 302 SIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLA 335
Cdd:COG0738  344 IVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLI 377
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 167-341 8.71e-05

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 44.07  E-value: 8.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 167 PFLRYTAALTLINTGFFiPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVpgpVARLLMLWTTLTGV- 245
Cdd:cd17370  201 AFWLYLLAVALFALGNF-SFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRI---GRKKLLILGYLSLAl 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 246 SLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGnYTAS 325
Cdd:cd17370  277 AYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLIS-PSAA 355

                        170
                 ....*....|....*.
gi 568975606 326 FVVAGAFLLAGSGVLL 341
Cdd:cd17370  356 FLFSAVLALIALLLLL 371
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 192-335 9.98e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 44.09  E-value: 9.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 192 HLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPGpvaRLLMLWTTLTGVSLALFPVAQASSTLV--VLAVAYGFT 269
Cdd:cd17477  214 YGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDR---RRVLLGCALLGALAALLLPLVPGLPLAllVLLFLWGGA 290

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568975606 270 SGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGN---YTASFVVAGAFLLA 335
Cdd:cd17477  291 AGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPhglFLFLAAVALLFLLF 359
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
173-336 1.11e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 43.71  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 173 AALTLINTGFFIPYVhlvahLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPgpVARLLMLWTTLTGVSLALFPV 252
Cdd:COG2271   22 NYLDRSNLSVAAPPL-----QADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFG--RRRVLAIGLLLWGLATLLFGF 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 253 AQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAF 332
Cdd:COG2271   95 ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPG 174


                 ....
gi 568975606 333 LLAG 336
Cdd:COG2271  175 LLLA 178
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 151-341 1.82e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 42.97  E-value: 1.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 151 AVGGPGAQITSLLRhGPFLRYTAALTLINTGFFIPYVHLVAHLQ-DLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVP 229
Cdd:cd17316  163 LIGALPALLALLLR-RRTLLLILLWFFISFGYYGLTTFLPTYLQtVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIG 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 230 GPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGA 309
Cdd:cd17316  242 RKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAP 321

                        170       180       190
                 ....*....|....*....|....*....|..
gi 568975606 310 PLSGYLRDVTGNYTASFVVAGAFLLAGSGVLL 341
Cdd:cd17316  322 PLIALLLASTGGTGVPALILALLAIVALIVAL 353
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 168-341 2.28e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 42.99  E-value: 2.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 168 FLRYTAALTLINTGFFIPYVHLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPgpvARLLMLWTTLT-GVS 246
Cdd:cd06173    1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFD---RRRLLILADLLrALL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 247 LALFPVAQASST-----LVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGN 321
Cdd:cd06173   78 AAVLALLALLGSlslwlLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGP 157

                        170       180
                 ....*....|....*....|
gi 568975606 322 YTASFVVAGAFLLAGSGVLL 341
Cdd:cd06173  158 GGAFAINALSFLLSALLLLF 177
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 69-336 3.63e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 42.20  E-value: 3.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  69 GWALTFTPTMACLSRYF-SQRRSLAMGLALTGVGISSFAFAPLFQWLINNYAWRGALLLVSALSLHLMACgALLRPLSLT 147
Cdd:cd17489   97 GWGAFTTAAATLVADIIpPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLL-VFLVKDPPP 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 148 EDAAVGGPGAQITSLLRHGPFLRYTAALTLINTGFFIPYVHLVAHLQDLGWDplPAAFLLSVAAVSDLVGRVASGWLGDA 227
Cdd:cd17489  176 VAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGIS--NAGLFFTVYAIALLLSRPFSGKLSDR 253

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 228 VPGpvARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLL 307
Cdd:cd17489  254 KGP--KTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGL 331

                        250       260
                 ....*....|....*....|....*....
gi 568975606 308 GAPLSGYLRDVTGnYTASFVVAGAFLLAG 336
Cdd:cd17489  332 GGLLLGLVAELFG-YRAMFLLAAVVVLLA 359
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 194-343 1.15e-03

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 40.72  E-value: 1.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 194 QDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGD-AVPGPVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVA-YGFTSG 271
Cdd:cd17312  212 EVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDkLFGGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFlIGFFVG 291

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 568975606 272 ALTPVAFSVLPELVGTGRIyCG--MGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTL 343
Cdd:cd17312  292 GPINLIGGAAAQDIGRKEA-AGtaTGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLSLW 364
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 167-313 1.30e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 40.62  E-value: 1.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 167 PFLRYTAALTLINTGFFIPYVHLVAHLQD-LGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAV-PGPVARLLMLWTTLTG 244
Cdd:cd17321  169 TFSGAVLAAFLLGAALGGLLFLLPLYLQGvLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFgPRLVLVAGLLLTAVGL 248

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568975606 245 VSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSG 313
Cdd:cd17321  249 LLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLG 317
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 180-345 1.49e-03

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 40.26  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 180 TGFFIPYvhLVAHLQDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPGPvaRLLMLWTTLTGVS--LALFPVAQASS 257
Cdd:cd17335   13 LGSLLPF--LSVYLKQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGKR--KALLLLSLLAAVLffLSLFFVAQIFW 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 258 TLVVLAVAYGFTSGALTPVAFSVLPELVG-TGRIYcgmGLVQMIESIGGLLGAPLSGYLRDVTG---NYTASFVVAGAFL 333
Cdd:cd17335   89 LLLLLVILGAFFSAPVVPLVDSITLQYLGeERERY---GKQRLWGSIGFGIAALLVGILIDRSStykNYTIAFYVFAVLM 165

                        170
                 ....*....|..
gi 568975606 334 LAGSGVLLTLPH 345
Cdd:cd17335  166 LLALLLALKFPF 177
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 207-336 2.40e-03

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 39.56  E-value: 2.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 207 LSVAAVSDLVGRVASGWLGDAVPGpvARLLMLwtTLTGVSLALFPVAQASS--TLVVLAVAYGFTSGALTPVAFSVLPEL 284
Cdd:cd17391  246 FSATGVSSLLSAPRLGKLGDRIGH--HRILLG--ALLASALLYIPQAFVQTpwQLGILRFLLGLATGGLLPAINSLLAKI 321

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568975606 285 V---GTGRIYcgmGLVQMIESIGGLLGAPLSGYLRDVTGnYTASFVVAGAFLLAG 336
Cdd:cd17391  322 TpkeVAGRIF---GYNQSFQYLGNVAGPLLGSAIAAHFG-YRAVFVVTALLVLLN 372
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 162-343 2.94e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.52  E-value: 2.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 162 LLRHGPFLRYTAALTLINTGFFIPYVHLVAHL--QDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPgpVARLLMLW 239
Cdd:cd06173  203 YLRRSPLLRLLLLALALFALLGGALTVLLPLLakEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRR--RGRLLLIG 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 240 TTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGT---GRIycgMGLVQMIESIGGLLGAPLSGYLR 316
Cdd:cd06173  281 ALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDelrGRV---FSVYNALNSGAMPLGALLAGLLA 357

                        170       180
                 ....*....|....*....|....*..
gi 568975606 317 DVTGnYTASFVVAGAFLLAGSGVLLTL 343
Cdd:cd06173  358 DALG-LSAVFLLAGALLLLAALLLLLL 383
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
194-344 5.57e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 38.71  E-value: 5.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 194 QDLGWDPLPAAFLLSVAAVSDLVGRVASGWLGDAVPGpvARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGAL 273
Cdd:COG2223   33 EEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGP--RRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGS 110

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568975606 274 TPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLTLP 344
Cdd:COG2223  111 FAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLR 181
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 54-342 5.79e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 38.32  E-value: 5.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  54 WIASIGIAVQQFGSSGwaLTFTPTMACLSRYFSQRRSLAMGL--ALTGVGISSFafaPLFQWLINNYAWRGALLLVSALS 131
Cdd:cd17474   88 ALLLAGRALQGIGAAG--LGPLALTLIGDLFEGGERAKAMGLyeAALGLGIAVG---PLLGGLLAAISWRYPFFLLAALI 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 132 LHLMACGALLRPLSLTEDAAVGGPGAQITSLLRHGPFLRYTAALT-LINTGFF--IPYVHLVAHLqDLGWDPLPAAFLLS 208
Cdd:cd17474  163 PVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAfLYFFLYFafLTYLPFLLEL-LYGISPIIIGLLFA 241

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606 209 VAAVSDLVGRVASGWLGDAVPGpVARLLMLWTTLTGVSLALFPVAQASSTLVVLAVAYGFTSGALTPVAFSVLPELVGTG 288
Cdd:cd17474  242 GWSVLLALGSLFVGRLLKKRFG-ARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEE 320

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 568975606 289 RIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVLLT 342
Cdd:cd17474  321 ERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
ATG22 pfam11700
Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which ...
 261-341 6.76e-03

Vacuole effluxer Atg22 like; Autophagy is a major survival survival mechanism in which eukaryotes recycle cellular nutrients during stress conditions. Atg22, Avt3 and Avt4 are partially redundant vacuolar effluxes, which mediate the efflux of leucine and other amino acids resulting from autophagy. This family also includes other transporter proteins.


Pssm-ID: 371676  Cd Length: 479  Bit Score: 38.40  E-value: 6.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975606  261 VLAVAYGFTSGALTPVAFSVLPELVGTGRIYCGMGLVQMIESIGGLLGAPLSGYLRDVTGNYTASFVVAGAFLLAGSGVL 340
Cdd:pfam11700 387 VLQAFYGLVLGGLRSYSRSLYSELIPRGKEAQFFSLYAITDKGSSWIGPLIVGAIQDRTGNIRSPFVFLAILLVVPLPLL 466


                  .
gi 568975606  341 L 341
Cdd:pfam11700 467 L 467
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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