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Conserved domains on  [gi|568975061|ref|XP_006533914|]
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tumor necrosis factor receptor superfamily member 13B isoform X1 [Mus musculus]

Protein Classification

tumor necrosis factor receptor family protein( domain architecture ID 10194110)

tumor necrosis factor receptor (TNFR) family protein may interact with TNF superfamily (TNFSF) ligands (TNFL) to control key cellular processes such as differentiation, proliferation, apoptosis, and cell growth; similar to Rattus norvegicus tumor necrosis factor receptor superfamily member 8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TNFRSF13B cd13415
Tumor necrosis factor receptor superfamily member 13B (TNFRSF13B), also known as transmembrane ...
 6-209 2.06e-99

Tumor necrosis factor receptor superfamily member 13B (TNFRSF13B), also known as transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI); TNFRSF13B (also known as transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI), CVID, RYZN, CD267, CVID2, TNFRSF14B) is mainly expressed on B cells and binds strongly to B cell activating factor (BAFF) and weakly to a proliferation-inducing ligand (APRIL). TACI-APRIL interactions induce B-cell differentiation, whereas TACI-BAFF ligation negatively regulates B-cell functions. In humans, TACI is expressed on memory B cells and TACI mutations are detected in 8-10% of common variable immunodeficiency (CVID) patients, making it the most frequently mutated gene for the disease. Coexisting morbidities in CVID include bronchiectasis, autoimmunity, and malignancies. However, TNFRSF13B/TACI defects alone do not result in CVID but may also be found frequently in distinct clinical phenotypes, including benign lymphoproliferation and IgG subclass deficiencies. Over-expression of TACI has been detected in multiple myeloma and thyroid carcinoma; correlative analyses suggest that TACI expression is a useful prognostic marker for lymphoma.


:

Pssm-ID: 276920  Cd Length: 212  Bit Score: 288.59  E-value: 2.06e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975061   6 CPKDQYWDSSRKSCVSCALTCSQRSQRTCTDFCKFINCRKEQGRYYDHLLGACVSCDSTCTQHPQQCAHFCEKRPRSQAN 85
Cdd:cd13415    1 CPDEQYWDSLVGQCISCSLICSRRSVRTCAAFCKSMSCNKEQGKYYDHLLKDCISCASVCGQHPKQCAPFCENKLRSRVN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975061  86 LQPELGRPQAGEVEVRSDNSGR-----HQGSEHGPGL----RLSSDQLTLYCTLGVCLCAIFCCFLVALASFLRRRGEPL 156
Cdd:cd13415   81 LPPPLRRQQSGETETRSDNSGRyqgseHRGSEAGPALpgpkLSADQLLLVYCTLGLCLCAIVCCFLVAVACFLRRRGEPL 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568975061 157 PSQPAGPRGSQANSPHaHRPVTEACDEVTASPQPVETCSFCFPERSSPTQESA 209
Cdd:cd13415  161 SCQPAAGPCRLRAKSS-KDRLVEAGSVGDGVPEPVETCSFCFPEHRSPTQESA 212
 
Name Accession Description Interval E-value
TNFRSF13B cd13415
Tumor necrosis factor receptor superfamily member 13B (TNFRSF13B), also known as transmembrane ...
 6-209 2.06e-99

Tumor necrosis factor receptor superfamily member 13B (TNFRSF13B), also known as transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI); TNFRSF13B (also known as transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI), CVID, RYZN, CD267, CVID2, TNFRSF14B) is mainly expressed on B cells and binds strongly to B cell activating factor (BAFF) and weakly to a proliferation-inducing ligand (APRIL). TACI-APRIL interactions induce B-cell differentiation, whereas TACI-BAFF ligation negatively regulates B-cell functions. In humans, TACI is expressed on memory B cells and TACI mutations are detected in 8-10% of common variable immunodeficiency (CVID) patients, making it the most frequently mutated gene for the disease. Coexisting morbidities in CVID include bronchiectasis, autoimmunity, and malignancies. However, TNFRSF13B/TACI defects alone do not result in CVID but may also be found frequently in distinct clinical phenotypes, including benign lymphoproliferation and IgG subclass deficiencies. Over-expression of TACI has been detected in multiple myeloma and thyroid carcinoma; correlative analyses suggest that TACI expression is a useful prognostic marker for lymphoma.


Pssm-ID: 276920  Cd Length: 212  Bit Score: 288.59  E-value: 2.06e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975061   6 CPKDQYWDSSRKSCVSCALTCSQRSQRTCTDFCKFINCRKEQGRYYDHLLGACVSCDSTCTQHPQQCAHFCEKRPRSQAN 85
Cdd:cd13415    1 CPDEQYWDSLVGQCISCSLICSRRSVRTCAAFCKSMSCNKEQGKYYDHLLKDCISCASVCGQHPKQCAPFCENKLRSRVN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975061  86 LQPELGRPQAGEVEVRSDNSGR-----HQGSEHGPGL----RLSSDQLTLYCTLGVCLCAIFCCFLVALASFLRRRGEPL 156
Cdd:cd13415   81 LPPPLRRQQSGETETRSDNSGRyqgseHRGSEAGPALpgpkLSADQLLLVYCTLGLCLCAIVCCFLVAVACFLRRRGEPL 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568975061 157 PSQPAGPRGSQANSPHaHRPVTEACDEVTASPQPVETCSFCFPERSSPTQESA 209
Cdd:cd13415  161 SCQPAAGPCRLRAKSS-KDRLVEAGSVGDGVPEPVETCSFCFPEHRSPTQESA 212
TACI-CRD2 pfam09305
TACI, cysteine-rich domain; Members of this family are predominantly found in tumour necrosis ...
 41-79 2.44e-17

TACI, cysteine-rich domain; Members of this family are predominantly found in tumour necrosis factor receptor superfamily, member 13b (TACI), and are required for binding to the ligands APRIL and BAFF.


Pssm-ID: 370419  Cd Length: 39  Bit Score: 73.22  E-value: 2.44e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568975061   41 INCRKEQGRYYDHLLGACVSCDSTCTQHPQQCAHFCEKR 79
Cdd:pfam09305   1 LSCRKEQGRYYDHLLRDCISCSSICGQHPKQCAHFCENK 39
 
Name Accession Description Interval E-value
TNFRSF13B cd13415
Tumor necrosis factor receptor superfamily member 13B (TNFRSF13B), also known as transmembrane ...
 6-209 2.06e-99

Tumor necrosis factor receptor superfamily member 13B (TNFRSF13B), also known as transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI); TNFRSF13B (also known as transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI), CVID, RYZN, CD267, CVID2, TNFRSF14B) is mainly expressed on B cells and binds strongly to B cell activating factor (BAFF) and weakly to a proliferation-inducing ligand (APRIL). TACI-APRIL interactions induce B-cell differentiation, whereas TACI-BAFF ligation negatively regulates B-cell functions. In humans, TACI is expressed on memory B cells and TACI mutations are detected in 8-10% of common variable immunodeficiency (CVID) patients, making it the most frequently mutated gene for the disease. Coexisting morbidities in CVID include bronchiectasis, autoimmunity, and malignancies. However, TNFRSF13B/TACI defects alone do not result in CVID but may also be found frequently in distinct clinical phenotypes, including benign lymphoproliferation and IgG subclass deficiencies. Over-expression of TACI has been detected in multiple myeloma and thyroid carcinoma; correlative analyses suggest that TACI expression is a useful prognostic marker for lymphoma.


Pssm-ID: 276920  Cd Length: 212  Bit Score: 288.59  E-value: 2.06e-99
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975061   6 CPKDQYWDSSRKSCVSCALTCSQRSQRTCTDFCKFINCRKEQGRYYDHLLGACVSCDSTCTQHPQQCAHFCEKRPRSQAN 85
Cdd:cd13415    1 CPDEQYWDSLVGQCISCSLICSRRSVRTCAAFCKSMSCNKEQGKYYDHLLKDCISCASVCGQHPKQCAPFCENKLRSRVN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568975061  86 LQPELGRPQAGEVEVRSDNSGR-----HQGSEHGPGL----RLSSDQLTLYCTLGVCLCAIFCCFLVALASFLRRRGEPL 156
Cdd:cd13415   81 LPPPLRRQQSGETETRSDNSGRyqgseHRGSEAGPALpgpkLSADQLLLVYCTLGLCLCAIVCCFLVAVACFLRRRGEPL 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 568975061 157 PSQPAGPRGSQANSPHaHRPVTEACDEVTASPQPVETCSFCFPERSSPTQESA 209
Cdd:cd13415  161 SCQPAAGPCRLRAKSS-KDRLVEAGSVGDGVPEPVETCSFCFPEHRSPTQESA 212
TACI-CRD2 pfam09305
TACI, cysteine-rich domain; Members of this family are predominantly found in tumour necrosis ...
 41-79 2.44e-17

TACI, cysteine-rich domain; Members of this family are predominantly found in tumour necrosis factor receptor superfamily, member 13b (TACI), and are required for binding to the ligands APRIL and BAFF.


Pssm-ID: 370419  Cd Length: 39  Bit Score: 73.22  E-value: 2.44e-17
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 568975061   41 INCRKEQGRYYDHLLGACVSCDSTCTQHPQQCAHFCEKR 79
Cdd:pfam09305   1 LSCRKEQGRYYDHLLRDCISCSSICGQHPKQCAHFCENK 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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