|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
1-326 |
3.88e-130 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 379.86 E-value: 3.88e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 1 MCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRPVATNEV 80
Cdd:TIGR00892 122 LAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFESFGWRGSFLILGGLLLHCCVCGALMRPVGPSQR 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 81 PEP---KEDPLLPPKIPTRSCLAtCVSTIRYHLAFDILRHNmGFCIYVTGVTWMNLGFALPHIFLVPYAMHHGVDDYWAA 157
Cdd:TIGR00892 202 VSKsksKEGLPPDGSTKKLSKKS-TAEKINRFLDFSLFTHR-GFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAA 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 158 MLMSIVGFCNIFLRPMAGLLlAGRKSLAAYRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVL 237
Cdd:TIGR00892 280 FLLSIIGFVDIFARPSCGLI-AGLKWIRPHVQYLFSFALLFNGLTHLLCALAGDYTGLVIYCIFFGLSFGSVGALLFEVL 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 238 MDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLILGVGFYA-------AEKKKLKQ 310
Cdd:TIGR00892 359 MDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVSAGLFLAIGNYInyrllakEQKAALER 438
|
330
....*....|....*.
gi 568973439 311 DGQAKMENATSEMTPM 326
Cdd:TIGR00892 439 EGARDKKDAEGDSRES 454
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
1-300 |
2.22e-123 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 359.47 E-value: 2.22e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 1 MCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRPvatnev 80
Cdd:cd17425 106 FCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWRGSFLVFGGVLLNCCVCGAVMRP------ 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 81 pepkedpllppkiptrsclatcvstiryhlafdiLRHNMGFCIYVTGVTWMNLGFALPHIFLVPYAMHHGVDDYWAAMLM 160
Cdd:cd17425 180 ----------------------------------FCSNTRYQIYTLGVTWMVLGFVLPLIYLVPYATSNGMDESKAALLL 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 161 SIVGFCNIFLRPMAGLLlAGRKSLAAYRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDI 240
Cdd:cd17425 226 SILGFINIFMRPLAGLL-SGLPVFKGRRIYLFSLALLLNGLSNLICAISASFPVLLVYCLLYSISMSGIGSLIFQVLMDT 304
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 241 VPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLILGVGF 300
Cdd:cd17425 305 VEMDRFPSALGLFTILESVTILIGPPLAGLLVDITQQYSYVFYASSIFVVSAALFMGLSF 364
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
1-299 |
3.56e-64 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 208.04 E-value: 3.56e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 1 MCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRPvatnev 80
Cdd:cd17430 106 LALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEEYGWRGGFLILGGLLLNCCTCGAVMRP------ 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 81 pepkedpllppkiptrsclatcvstiryhLAFDILRhNMGFCIYVTGVTWMNLGFALPHIFLVPYAMHHGVDDYWAAMLM 160
Cdd:cd17430 180 -----------------------------LDFSVFR-DRGFVIYTIAKFIMVLGLFVPPIFVVNYAKDIGVPDTEAAFLL 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 161 SIVGFCNIFLRPMAGLLlAGRKSLAAYRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDI 240
Cdd:cd17430 230 SILGFIDIFARPACGVV-AGLKWVRPRVVYLFSFAMLFNGLTDLCSATAADYGGLVVFCVFFGISYGMVGALQFEVLMAI 308
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 568973439 241 VPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLILGVG 299
Cdd:cd17430 309 VGTQKFSSAIGLVLLVEAVAVLIGPPSAGRLVDATKNYELIFYLAGSEVVLSALFLALG 367
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
1-296 |
4.53e-64 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 207.41 E-value: 4.53e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 1 MCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRpvatnev 80
Cdd:cd17352 106 LGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLLR------- 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 81 pepkedpllppkiptrsclatcvstiryhlafdiLRHNMGFCIYVTGVTWMNLGFALPHIFLVPYAMHHGVDDYWAAMLM 160
Cdd:cd17352 179 ----------------------------------LLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLL 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 161 SIVGFCNIFLRPMAGLLlAGRKSLaaYRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDI 240
Cdd:cd17352 225 SIIGISDIVGRILLGLL-ADKPRI--GRLYLYIFTLLILGLSLLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADL 301
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 568973439 241 VPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLIL 296
Cdd:cd17352 302 VGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGVLL 357
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
1-299 |
1.07e-51 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 175.39 E-value: 1.07e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 1 MCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRPVAtnev 80
Cdd:cd17427 106 LAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWRGSFLILGGLLLNCCVAGSLMRPLG---- 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 81 pepkedPLLPPKiptrsclatcvstiryhlafdilrhnmGFCIYVTGVTWMNLGFALPHIFLVPYAMHHGVDDYWAAMLM 160
Cdd:cd17427 182 ------PLFKHR---------------------------GFLIYLSGNVIMFLGFFAPIVFLAPYAKHMGIDEYSAAFLL 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 161 SIVGFCNIFLRPMAGLLlAGRKSLAAYRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDI 240
Cdd:cd17427 229 SILAFVDMFARPSMGLV-ANSKWIRPRIQYFFSFAVMYNGVCHLLCPLAEDYTGLVIYAVFFGFAFGMVSSVLFETLMDL 307
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 568973439 241 VPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLILGVG 299
Cdd:cd17427 308 VGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDVTGNYKYMYFVCGAIVIVASIWLFIG 366
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
4-296 |
6.75e-42 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 150.23 E-value: 6.75e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 4 SFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRPVATnevpep 83
Cdd:cd17423 109 VFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAWRGALLLLSALSLHLVPCGALLRPLAL------ 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 84 KEDPLLPPKiptrsclatcvstiRYHLAFDI-LRHNMGFCIYVTGVTWMNLGFALPHIFLVPYAMHHGVDDYWAAMLMSI 162
Cdd:cd17423 183 PGDPPAPPR--------------SLSAAFGLsLLTHRAFLRYALATTLINTGYFIPYVHLVAHARALGLGEYQAAFVVSV 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 163 VGFCNIFLRPMAGLLlagrKSLAAYRK-YLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIV 241
Cdd:cd17423 249 AAVADAVGRLFSGWL----ADLGPLRLlHLLVLWTALTGLSLLLLPLAKVYGSLLALAVAYGFCAGALAPLVFSVLPELV 324
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 568973439 242 PMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLIL 296
Cdd:cd17423 325 GVERVLNATGLLQMIESVGGLLGPPLSGWLRDITGDYTASFLVAGSFLLLGSLIL 379
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
1-299 |
1.12e-39 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 143.86 E-value: 1.12e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 1 MCFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRPVAtnev 80
Cdd:cd17426 106 LAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWRGSFLILGGLLLNCCVAGSLMRPIG---- 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 81 PEPkedpllppkiptrsclatcvstiryHLAFDILRHNmGFCIYVTGVTWMNLGFALPHIFLVPYAMHHGVDDYWAAMLM 160
Cdd:cd17426 182 PKP-------------------------FLDLTLFTHR-GFLLYLSGNVIMFFGLFAPLVFLSNYAKSKQISNESAAFLL 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 161 SIVGFCNIFLRPMAGLLlAGRKSLAAYRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDI 240
Cdd:cd17426 236 SILAFVDMVARPSMGIV-ANTKWVRPRIQYFFAASVLYNGVCHLLAPLSTSYVGFCIYAIFFGFAFGWLSSVLFETLMDL 314
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 568973439 241 VPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLILGVG 299
Cdd:cd17426 315 VGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDIYGDYKYTYWACGIVLIISSIYLFIG 373
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
2-298 |
8.27e-29 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 114.46 E-value: 8.27e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 2 CFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRpvatnevp 81
Cdd:cd17422 107 CFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWRYCLLVVGALQLNIVVCGALLR-------- 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 82 epkedpllppkiptrsclatcvstiryhlafdILRhNMGFCIYVTGVTWMNLGFALPHIFLVPYAMHHGVDDYWAAMLMS 161
Cdd:cd17422 179 --------------------------------VLK-EPGFICYALFGLFATLGFFAPQLYIIPLSLSLGIDQDWAAYMLS 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 162 IVGFCNIFLRPMAGLLLagrkSLAAYRK-YLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLM-- 238
Cdd:cd17422 226 AMAIAELFGRISAGWVL----NKCPIRKiYIELICVILLCVVLLLFPFAYGFWSLLVCSIFYGFMFGTVAGTHIPLLAed 301
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 239 DIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLILGV 298
Cdd:cd17422 302 DVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVDWTQNYGSAFYSCAAGMALGAVFLAL 361
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
1-297 |
9.38e-28 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 111.44 E-value: 9.38e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 1 MCFSfqSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRPvatnev 80
Cdd:cd17424 108 LCYS--PAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRF------ 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 81 pepkedpLLPPkiptrsclatcvstiryhlafdilrhnmGFCIYVTGVTWMNLGFALPHIFLVPYAMHHGVDDYWAAMLM 160
Cdd:cd17424 180 -------LLMP----------------------------DFLVLAVSVLFLAYGCSPPFVYLVPYALSVGVSHQQAAFLM 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 161 SIVGFCNIFLRPMAGLLlAGRKSLAAYRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDI 240
Cdd:cd17424 225 SILGVIDIIGNITFGWL-TDRRCLKKYRYFCYLFAVGMDGLCCLFLPILKTFPLLVPFSFTFGYFDGAYVALIPVVTSDV 303
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 568973439 241 VPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLILG 297
Cdd:cd17424 304 VGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGTYTAAFLLSGFSMIFSSLLLG 360
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
2-287 |
5.94e-21 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 92.58 E-value: 5.94e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 2 CFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLlARYLLETLGWRGAFLIFGGILLHCCVCGALLRPVATNevp 81
Cdd:cd17421 107 AFLYQAAAVMTAKYFKKRLATAYAIARSGMGLTFALAPF-TQLLLDEYDWQGALLIFGGIMLNLVASGMLLRPIDFS--- 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 82 ePKEDPLlppkiptrsclatcvstiryhlafdilrhnmgFCIYVTGVTWMNLGFALPHIFLVPYAMHHGVDDYWAAMLMS 161
Cdd:cd17421 183 -LLKDPF--------------------------------FCIYTWSFVFSQLAYFIPYFHLVARARTLGIDPMDASFIIS 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 162 IVGFcnifLRPMAGLLLAGRKSLAAYRKYLFAVAILI-NGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDI 240
Cdd:cd17421 230 VAGI----TETVAQLASGWIADQNWIKKYHYHKAYLIlCGVTNLLAPLATTYPLLMTYAVFFAIFCGGYLALLLPVLVDL 305
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 568973439 241 VPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSG 287
Cdd:cd17421 306 VGVTKVNSSLGFSMFFAGIGCLTGPPLAGWLYDYTQTYDCSFYLAGG 352
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
3-296 |
3.33e-20 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 90.71 E-value: 3.33e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 3 FSFQSSITVVGLYF-VRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRPVATNEVP 81
Cdd:COG2223 109 GSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAA 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 82 EPKEDPLLPPKIPTRSclatcvstiryhlafdilRHNMGFCIYVTGVTWMNLGFALphiFLVPYAM-HHGVDDYWAAMLM 160
Cdd:COG2223 189 AAAKASLRDQLEALRD------------------PRFWLLSLLYFGTFGSFIGFSS---WLPPYLVdQFGLSAATAGLLA 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 161 SIVGFCNIFLRPMAGLL---LAGRKSLAAyrkyLFAVAILINGLTNLIctvSADFRVLLGYCLVYSLSMCGVGILVFQVL 237
Cdd:COG2223 248 ALFALLGALGRPLGGWLsdrIGGRRVLLI----VFALMALGLLLLALA---LGSLWLFLVLFLLLGLALGGGNGAVFALV 320
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 568973439 238 MDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLIL 296
Cdd:COG2223 321 PDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALVLT 379
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
7-296 |
4.17e-15 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 75.29 E-value: 4.17e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 7 SSITVVGLYF-VRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLhccvcgallrpvatnevpepke 85
Cdd:COG2271 118 AALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGL---------------------- 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 86 dpllppkiptrscLATCVSTIryhlafdilrhnmGFCIYVTGVTWMNLGFALphiFLVPYAM-HHGVDDYWAAMLMSIVG 164
Cdd:COG2271 176 -------------LLALLRFW-------------LLALAYFLVYFALYGFLT---WLPTYLVeVRGLSLAQAGLLLSLPF 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 165 FCNIFLRPMAGLLlAGRksLAAYRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMD 244
Cdd:COG2271 227 LAGIVGSLLGGWL-SDR--LGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKK 303
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 568973439 245 RFPSALGLFTILCGVTSLISPPLAGLLLDKTnNFSYVFYMSSGFLVSGSLIL 296
Cdd:COG2271 304 ARGTASGLVNTFGFLGGALGPLLVGYLLDAT-GYQAAFLLLAALALLAALLA 354
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
2-296 |
5.04e-15 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 75.39 E-value: 5.04e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 2 CFSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLhccvcgALLRPVATNEVP 81
Cdd:cd17355 108 TLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLAL------LVLVPVLLLLRR 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 82 EPKEDPLLPPKIPTRSCLATCVSTIRYHLAFDILRHNMGFC-IYVTGVTwmnlgfalphIFLVPYAMHHGVDDYWAAMLM 160
Cdd:cd17355 182 RPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCgFAVVGLI----------VHLVPYLADRGISPAAAAVAL 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 161 SIVGFCNIFLRPMAGlLLAGRKSlaayRKYLFAVAILINGLTNLICTVS-ADFRVLLGYCLVYSLSMCGVGILVFQVLMD 239
Cdd:cd17355 252 ALIGLFNIVGRLLSG-WLGDRYS----PRRLLAASYALRALGLALLLLLpFPPLALLLFAALFGLGWGATVPLTAALAAR 326
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 568973439 240 IVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLIL 296
Cdd:cd17355 327 YFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLV 383
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
18-296 |
1.48e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 74.00 E-value: 1.48e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 18 RRRPLANALASMGLSMGVTLWPLLARYLLE--TLGWRGAFLIFGGILLHCCVCGALLRPVATNEVPEPKEdpllppkipt 95
Cdd:cd06174 116 RERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNE---------- 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 96 rsclatCVSTIRYHLAFDILRHNMGFCIYVTGVTWMNLGFALPHIFLVPYAMHHGVDDYW-AAMLMSIVGFCNIFLRPMA 174
Cdd:cd06174 186 ------EASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAvAGLLLSLFGLAGALGSLLL 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 175 GLLLagrkSLAAYRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFT 254
Cdd:cd06174 260 GLLS----DRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLN 335
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 568973439 255 ILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLIL 296
Cdd:cd06174 336 TFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
1-265 |
1.94e-14 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 73.22 E-value: 1.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 1 MCFSFQSSITVVGLYF-VRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRPVATNE 79
Cdd:pfam07690 99 AGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESK 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 80 VPEPKEDPLLPPKIPTRsclatcvstiryhlafdILRHNMGFCIYVTGVTWMNLGFALPhIFLVPYAMHHGVDDYWAAML 159
Cdd:pfam07690 179 RPKPAEEARLSLIVAWK-----------------ALLRDPVLWLLLALLLFGFAFFGLL-TYLPLYQEVLGLSALLAGLL 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 160 MSIVGFCNIFLRPMAGLLLagRKSLAAYRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMD 239
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLS--DRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318
|
250 260
....*....|....*....|....*.
gi 568973439 240 IVPMDRFPSALGLFTILCGVTSLISP 265
Cdd:pfam07690 319 LAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
11-303 |
2.39e-13 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 70.29 E-value: 2.39e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 11 VVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLhccVCGALLRPVATNEVPEPKEDPLLP 90
Cdd:COG2807 130 LIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLAL---LALLLWLPLLRRRPAAAAAAPAAA 206
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 91 PKIPT-RSCLATCVSTIryhlafdilrhnMGFCiyvtgvtwmNLGFALPHIFLVPYAMHHGVDDYWAAMLMSIVGFCNIF 169
Cdd:COG2807 207 SLRSLwRSPLAWLLTLF------------FGLQ---------SLLYYAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIP 265
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 170 LRPMAGLLLAGRKslaayRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSA 249
Cdd:COG2807 266 GSLLVPLLADRLG-----DRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAA 340
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 568973439 250 LGLFTILCG-VTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVsgsLILGVGFYAA 303
Cdd:COG2807 341 LSGMAQSVGyLLAALGPLLVGALHDATGSWTAALLLLAALAV---LMLVAGLLAG 392
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
4-284 |
2.47e-12 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 67.16 E-value: 2.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 4 SFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRpVATNEVpep 83
Cdd:cd17429 109 AYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWRNAMFIQGAVSLNLCVCGALMR-LFTNKV--- 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 84 kedpllppkiptrsclatcvstiryhlafdilrhnmgFCIYVTGVTWMNLGFALPHIFLVPYAMHHGVDDYWAAM-LMSI 162
Cdd:cd17429 185 -------------------------------------FVAFIFWALFAYCSFVIPFIHLPEIVKLYGLSEQNDKFpLTSI 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 163 VGFCNIFLRPMAGlLLAGRKSLAAYRKYLFAVAILinGLTNLICTVSADFRVLLGYCLVYSLSmCGVGILVFQVLMDIVP 242
Cdd:cd17429 228 IAIVHIFGKVILG-IICDLPCISVWNVFILANFTL--GVCILILPLMHTYTGLAIVCALIGFS-SGYFSLMPVVTEDLVG 303
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 568973439 243 MDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYM 284
Cdd:cd17429 304 IKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYV 345
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
3-296 |
2.22e-11 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 64.47 E-value: 2.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 3 FSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRPVATnevpe 82
Cdd:cd17420 113 FAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLDSYGLEGTLRVLSLFMFVLILCSFTYRPLHP----- 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 83 PKEDPllPPKIPTRSCLATCVSTIRYHLAFDILRHNMgFCIYVTGVTWMNLGFALPHIFLVPYAMHHGVDDYWAAMLMSI 162
Cdd:cd17420 188 SPEDP--KSKPGRRTLHSRINLFLRKIFNVEIFKRKR-YVIWALGIPLALFGYFVPYVHLMKFVKEEFFPGKDVNVPLMC 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 163 VGFCNIFLRPMAGLLLAGRKSLAayRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSL-SMCGVGILVfQVLMDIV 241
Cdd:cd17420 265 IGITSGIGRLIFGVIADMPPGVK--KMYLQVLSFVSIGLMSMMIPLCNSFGILISVCLVMGLfDGCFISIMA-PIAFELV 341
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 568973439 242 PMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLIL 296
Cdd:cd17420 342 GPSGASQAIGFLLGLMSIPMTVGPPIAGLLRDSTGSYTVAFYLAGVPPLIGSSLL 396
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
18-296 |
3.44e-10 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 60.67 E-value: 3.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 18 RRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRPvatNEVPEPKEDPLLPPKIPTRs 97
Cdd:cd17325 116 EERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLP---EPRPPPNKRAVSAARLRSG- 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 98 clatcvstiryhLAFDILRHNMGFCIYVTGVTWMNLGFALPhiFLVPYAMHH-GVDDYWAAMLMSIVGFCNIFLRPMAGL 176
Cdd:cd17325 192 ------------LRLLLRDRRLLALFLAIFVLAFAFGALEP--FLPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGK 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 177 LlAGRKSlaayRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTIL 256
Cdd:cd17325 258 L-SDRIG----RKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTA 332
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 568973439 257 CGVTSLISPPLAGLLLDkTNNFSYVFYMSSGFLVSGSLIL 296
Cdd:cd17325 333 FSLGMVLGPLLGGFLYD-AFGFATPFLAAAALLLLAAVLF 371
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
8-295 |
4.86e-09 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 57.31 E-value: 4.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 8 SITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLL-ETLGWRGAFLIFGGILLhccVCGALLRPVatneVPEPKED 86
Cdd:cd06180 109 SNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLgGGLSWRAGWLALALLSA---VLLLLSFLL----LRRGPSA 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 87 PllPPKIPTRSCLATCVSTIRYHLAFdiLRHNMGFCIYVTgvtwmnlgfalphiFLVPYAMHHGVDDYWAAMLMSIVGFC 166
Cdd:cd06180 182 P--TEASAAESAPGLNRPLWRLALAY--GLFGFGYIITAT--------------FLPLIARETGAGSLLAGLLWSLFGLA 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 167 NIFlrpmaGLLLAGRKSLAAYRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRf 246
Cdd:cd06180 244 AVP-----SCFLWGALSDRWGTRRALAANLLVQAVGVLLPLLSPGPAGLVLSAVLFGGTFMAITALVMALARELAPPAA- 317
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 568973439 247 PSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLI 295
Cdd:cd06180 318 PRALALMTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALL 366
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
131-296 |
5.88e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.91 E-value: 5.88e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 131 MNLGFALPHIFLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGLLlAGRKSlaayRKYLFAVAILINGLTNLICTVSA 210
Cdd:COG2814 22 SGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRL-ADRFG----RRRVLLLGLLLFALGSLLCALAP 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 211 DFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDkTNNFSYVFYMSSGFLV 290
Cdd:COG2814 97 SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-LFGWRWVFLVNAVLAL 175
|
....*.
gi 568973439 291 SGSLIL 296
Cdd:COG2814 176 LALLLL 181
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
18-261 |
6.86e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 56.52 E-value: 6.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 18 RRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRPVATNEVPEPKEDPLlppkiptrs 97
Cdd:COG2814 130 ERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL--------- 200
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 98 clatcvstiryhlaFDILRHNMGFCIYVTGVTWMNLGFALPhIFLVPYAMH-HGVDDYWAAMLMSIVGFCNIFLRPMAGl 176
Cdd:COG2814 201 --------------RELLRRPRLLLLLLLAFLLGFGFFALF-TYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAG- 264
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 177 LLAGRKSlaayRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTIL 256
Cdd:COG2814 265 RLADRFG----RRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSA 340
|
....*
gi 568973439 257 CGVTS 261
Cdd:COG2814 341 FFLGG 345
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
3-296 |
3.02e-08 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 54.80 E-value: 3.02e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 3 FSFQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRPVATNevPE 82
Cdd:cd17464 113 FAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLDSVGLFNTLRVLCIFMFVLFLAGFTYKPLVPM--KK 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 83 PKEDPLLPPKIPTRSCLatcvstiryhLAFDILRhNMGFCIYVTGVTWMNLGFALPHIFLVPYAMHHGVDDYWAAMLMSI 162
Cdd:cd17464 191 DKEGKKRKFKCPPLKKI----------FNFNIWK-STGYRIWAFGIPAALFGYFVPYVHLMNHVKERFGEDVNKEVLLMC 259
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 163 VGFCNiflrpMAGLLLAGRKS---LAAYRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSL-SMCGVGILVfQVLM 238
Cdd:cd17464 260 IGITS-----GIGRLIFGRVAdyiPGVKKVYLQVSSFFFIGLMSMMIPLCHVFGGLIAVCLFMGLfDGCFISIMA-PIAF 333
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 568973439 239 DIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLIL 296
Cdd:cd17464 334 ELVGAQNVSQAIGFLLGLMSIPMTVGPPIAGFLRDRLGSYDVAFYLAGVPPIIGGIIL 391
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
18-296 |
1.77e-07 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 52.24 E-value: 1.77e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 18 RRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLrpvatneVPEPKEDPLLPPKIPTRs 97
Cdd:cd17475 116 RERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLF-------YREPPAASAATESASTL- 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 98 clatcVSTIRYHLAFDILRHnmgfcIYVTGVTWMNLGFALpHIFLVPYAM-HHGVDDYWAAMLMSIVGFCNIFLRPMAGL 176
Cdd:cd17475 188 -----LRSLKEVLRNRDVWL-----IAIAGALLVAPQFAL-LTFLLLFLHdHLGLSVVAAGALLAVAQLGGALGRIGLGR 256
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 177 ----LLAGRkslaaYRKYLFAVAILINGLTNLI--CTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSAL 250
Cdd:cd17475 257 vsdrVFGGR-----RRPVLVITAAIAAAALLVLslLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAESAGPEQAGTAL 331
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 568973439 251 GLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLIL 296
Cdd:cd17475 332 GLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLL 377
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
5-296 |
8.52e-07 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 50.20 E-value: 8.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 5 FQSSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRpvatnevpepk 84
Cdd:cd17428 110 YAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYGLDGCLLIVGALALNLLACGSLMR----------- 178
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 85 edpLLPPKIPTRSCLATcvstiryhLAFDIlrhnmgfciyvtgvtwmnlGFALPHIFLVPYAMHHGVDDYWAAM-LMSIV 163
Cdd:cd17428 179 ---LFKNRVFSALFIAI--------LLFDI-------------------GAFPPSLLMEDVARSENIIEEIALIpLVSII 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 164 GFCNIFLRPMAGLLLAGR--KSLaayrkYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLsMCGVGILVFQVLMDIV 241
Cdd:cd17428 229 GITTAIGKLILGVLADFKwvNSL-----YLYVLTLIGMGAALLAIPFAKSYLTLAVLSAILGF-LSGNWSIFPYVTTKTV 302
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 568973439 242 PMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLIL 296
Cdd:cd17428 303 GIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFYFSGFCVLLGGFLL 357
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
121-296 |
1.45e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 49.46 E-value: 1.45e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 121 FCIYVTGVTWMNLGFAlPHIFLVPYAMHHGVDDYWAAMLMSIVgfcNIFLRPMAglLLAGRKSLAAYRKYLFAVAILING 200
Cdd:cd17370 202 FWLYLLAVALFALGNF-SFAFLILRAQELGLSAALIPLLYALF---NLVYALAA--YPAGRLSDRIGRKKLLILGYLSLA 275
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 201 LTNLICTVSADFRVLLGYCLVYslsmcGVGILVFQVLM-----DIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKT 275
Cdd:cd17370 276 LAYLGFALGSSLWLLLLGFILW-----GLYMGAQESIEraavaDLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLI 350
|
170 180
....*....|....*....|.
gi 568973439 276 nNFSYVFYMSSGFLVSGSLIL 296
Cdd:cd17370 351 -SPSAAFLFSAVLALIALLLL 370
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
7-298 |
3.17e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 48.34 E-value: 3.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 7 SSITVVGLYFV-RRRPLANALASMGLSMGVTLWPLLARYLLEtLGWRGAFLIFG-GILLHCCVCgALLRPVATNEVPEPK 84
Cdd:cd17473 108 LATALIGDYFEgEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLlALPVLILVL-LFLPEPARKSKSAAS 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 85 EDPLLPPKIPTRSCLATCVSTIryhlafdilrhnMGFCIYVTGVTwmNLGFALPHIFLVPYAMhhgvddywAAMLMSIVG 164
Cdd:cd17473 186 PGAATAAALPWKRVLPIYFLAF------------LAMLLFYVIPI--QLPFLLQERGGGSAAL--------IGLALAIAS 243
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 165 FCNiflrpMAGLLLAGRKSLAAYRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVyslSMCGVGIL---VFQVLMDIV 241
Cdd:cd17473 244 LAG-----AIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAIL---AGLGFGLLlptLNSWAMSLV 315
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 568973439 242 PMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLILGV 298
Cdd:cd17473 316 PPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLL 372
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
18-296 |
3.76e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 48.34 E-value: 3.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 18 RRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGIllhccvcGALLRPVATnevpepkedpLLPPKIPTRS 97
Cdd:cd17319 123 RERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLL-------GLLLAVLWW----------FYLRQVWGLA 185
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 98 CLATCVSTIRYHLAF---DILRHNMGFciyvtgvTWMNLGFALPHIFLVpyamhhgvddywAAMLMSIVGFCNIFLRPMA 174
Cdd:cd17319 186 LGYFGINYALYGLLTwlpTYLKQARGF-------SLKQVGLLAAIPFLA------------GAIGMILGGRLSDRLLRGA 246
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 175 glllagRKSLAAYRKYLFAVAILINGLTNlictvSADFRVLLgyclvysLSMCGVGILVFQVLMDIVPMDRFP-----SA 249
Cdd:cd17319 247 ------RRLVIIIGLLLAAVGLLLAYLTT-----SPVVAVIL-------LSLAGFGIGAASPVFWSLPADLLPgeaaaTA 308
|
250 260 270 280
....*....|....*....|....*....|....*....|....*..
gi 568973439 250 LGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLIL 296
Cdd:cd17319 309 GGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAALLV 355
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
133-296 |
5.85e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 47.59 E-value: 5.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 133 LGFALPHIFLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGLLLAGRKslaayRKYLFAVAILINGLTNLICTVSADF 212
Cdd:cd17489 10 LSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFG-----RKRLLLIGLLIFALATLLYLLATSV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 213 RVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLaGLLLDKTNNFSYVFYMSSGFLVSG 292
Cdd:cd17489 85 ALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPAL-GLFLYQHLGFAVLFIVAAVLALLA 163
|
....
gi 568973439 293 SLIL 296
Cdd:cd17489 164 LLLV 167
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
131-295 |
8.69e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.19 E-value: 8.69e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 131 MNLGFALPHIFLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGLLlAGRKSlaayRKYLFAVAILINGLTNLICTVSA 210
Cdd:cd17325 8 DMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRL-SDRFG----RKRLLLLGLLLLAVSTLLFAFAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 211 DFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTnNFSYVFYMSSGFLV 290
Cdd:cd17325 83 SYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-GYRAPFLVCAALAL 161
|
....*
gi 568973439 291 SGSLI 295
Cdd:cd17325 162 LALVL 166
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
23-302 |
1.32e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 46.45 E-value: 1.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 23 ANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRPVATNEVPEPKEDPLLppkiptrsclatc 102
Cdd:cd06173 129 ANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLLR------------- 195
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 103 vstiRYHLAFDILRHNMGFCIYVTGVTWMNLGFALPHIFLVPYAMHH-GVDDYWAAMLMSIVGFCNIflrpmAGLLLAGR 181
Cdd:cd06173 196 ----DLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVlGGGAAGYGLLLAAFGVGAL-----LGALLLGR 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 182 KSLAAYRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTS 261
Cdd:cd06173 267 LSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAM 346
|
250 260 270 280
....*....|....*....|....*....|....*....|.
gi 568973439 262 LISPPLAGLLLDKTNnfsyvfyMSSGFLVSGSLILGVGFYA 302
Cdd:cd06173 347 PLGALLAGLLADALG-------LSAVFLLAGALLLLAALLL 380
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
3-295 |
1.60e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.43 E-value: 1.60e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 3 FSFQSSITVVGLYF-VRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRPVATNEVP 81
Cdd:cd17489 100 AFTTAAATLVADIIpPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAE 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 82 EPKEDPLLPPKIPTRSCLATCVSTIryhLAFdilrhnMGFCIYVTgvtwmnlgfalphiFLVPYAMHHGVDDywAAMLMS 161
Cdd:cd17489 180 EAEAGTRAFRRLVEKKVLPPALILF---LAS------IAYGAIST--------------FLPLYAAERGISN--AGLFFT 234
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 162 IVGFCNIFLRPMAGLLlagrkSLAAYRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLsMCGVGILVFQVLM-DI 240
Cdd:cd17489 235 VYAIALLLSRPFSGKL-----SDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGL-GFGLLFPALQALAvDL 308
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 568973439 241 VPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTnNFSYVFYMSSGFLVSGSLI 295
Cdd:cd17489 309 VPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELF-GYRAMFLLAAVVVLLALVL 362
|
|
| MFS_4 |
pfam06779 |
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane ... |
8-296 |
2.59e-05 |
|
Uncharacterized MFS-type transporter YbfB; This family represents putative bacterial membrane proteins which may be sugar transporters. Members carry twelve transmembrane regions which are characteriztic of members of the major facilitator sugar-transporter superfamily.
Pssm-ID: 399632 [Multi-domain] Cd Length: 365 Bit Score: 45.44 E-value: 2.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 8 SITVVGLYFVRRRPLANALASMGLSMGVTLWPLLArYLLETLGWRGAFLIFGGILLhCCVCGALLRPVATNEVPEPKEDP 87
Cdd:pfam06779 105 SSLILGHATAARRAFVGALLFAGVGIGIALSGLLV-PLGLQLGLGGSSLWYGAGVL-SAVLTLAVFPLLPRRAPRHASAP 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 88 LLPPKIPTRScLATCVSTIRYHLAfdilrhNMGFCIYVTgvtwmnlgfalphiFLVPYAMHHGVDDYWAAMLMSIVGfCN 167
Cdd:pfam06779 183 APAAKPLQRS-LPLWILTLAYGLA------GFGYIITAT--------------FLPAMARDGFGGPAAAALFWSLFG-LA 240
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 168 IFLRPMAGLLLAGRKSLAAyrkyLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRfP 247
Cdd:pfam06779 241 AALGVLVWLRAAKRWGTRP----ALTAALLIQALGVLLSLLSPSPAGLAVSSLLFGGTFMAITSLVMQLARELAPPAP-R 315
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 568973439 248 SALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLIL 296
Cdd:pfam06779 316 RLLGLMTASFGIGQILGPLLASLLTAATGGLTPALLLAAAALVLAALIV 364
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
24-322 |
3.33e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.28 E-value: 3.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 24 NALASMGLSMGVTLWPLLARYLLET--LGWRGAFLIFGGIllhcCVCGALLRPVATNEVPEPKEdpllpPKIPTRSclat 101
Cdd:COG2211 153 FAFAGLGGLLASVLPPPLVAAFGGDaaLGYRLTALIFAVL----GLLAFLLTFFGTKERPVPEE-----EKVSLKE---- 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 102 cvstiryhlAFDILRHNMGFCIYVTGVTWMNLGFALPHIFLVPYAMHH-GVDDYWAAMLMSIVGFCNIFLRPMAGlLLAG 180
Cdd:COG2211 220 ---------SLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWP-RLAK 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 181 RKSlaayRKYLFAVAILINGLTNLICTVS--ADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPS-------ALG 251
Cdd:COG2211 290 RFG----KKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTgrrreglYFG 365
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568973439 252 LFTILCGVTSLISPPLAGLLLD-------KTNNFSYVFYMSSGFLVSGSLILGVGFYAAEKKKLKQDGQAKMENATSE 322
Cdd:COG2211 366 IFTFAIKLGQALAGALAGLLLAlfgyvagAAQSPSALTGIRLLFFLLPAVLLLLAALLLLFYPLTRERHAEIRAELAA 443
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
7-299 |
5.87e-05 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 44.71 E-value: 5.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 7 SSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLRPVATNEVPEPKEd 86
Cdd:cd17314 112 SAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGLALVYTILGILAAIVLSVVSLLGFKEPPDNQARLH- 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 87 pllPPKIPTRSCLATCVSTIRYHLAFDILRHNM-GFCIYVTGVTWMNLGFALPHIFLVPyamhhgvddywaamLMSIVGF 165
Cdd:cd17314 191 ---VQKKKTQTMGEIFRDKVFWILFIAIFLVLIgGFLFIANMASLVRSLQLDAPSFVTK--------------LMSIYGL 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 166 CNIFLRPMAGLLLAGRKSlaayRKYLFAVAILINGLT---NLICTVSADFRVLLGYCLVYsLSMCGVGILVFQVLMDIVP 242
Cdd:cd17314 254 FNAFGRLLWGIVADFFGG----RLSTLSILLTILGLGlcaFLFLLKMTPVGLVLTGSLLG-FSYGGLFTVYPATVSTVFG 328
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 568973439 243 MDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSGSLILGVG 299
Cdd:cd17314 329 TESFATLYGILLFAPAIGSILGPMLGAKFYDRTPSYISAVYIYAVIVFLASAILLAV 385
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
7-295 |
7.29e-05 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 44.14 E-value: 7.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 7 SSITVVGLYFVRRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGI-LLHCCVCGALLRPVATNEVPEPKE 85
Cdd:cd17353 112 TPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIfLIIIVIGAFLIRDPPKGWVPPGVD 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 86 DPLLPPKIPTRSCLAT-CVSTIRYHLAfdilrhnmgFCIYVTGVTWMNLGFAlphiFLVPYAMH-HGVDDYWAAMLMSIV 163
Cdd:cd17353 192 PLANNAENSPRDYTPReMLRTPTFWLL---------WLMFFLNATAGLMLIG----QAKPIGQEfAGLDAGIAALAVSIL 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 164 GFCNIFLRPMAGLL--LAGRKslaayRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSlsmCGVGI--LVFQVLMD 239
Cdd:cd17353 259 SIFNGGGRPFWGWLsdKIGRK-----NTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGF---CYGGGfaLFPALTAD 330
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 568973439 240 IVPMDRFPSALGLFTILCGVTSLISPPLAGlLLDKTNNFSYVFYMSSGFLVSGSLI 295
Cdd:cd17353 331 FFGTKNAGTNYGLLYTAKGVGGLIGPIIAA-YVLYTGGYNAAFIIAAALSLVALAL 385
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
119-296 |
9.87e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.56 E-value: 9.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 119 MGFCIYVTGVTWMNLGFALPHIFLVpyamHHGVDDYWAAMLMSIVGFCNIFLRPMAGLLlAGRKSlaayRKYLFAVAILI 198
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAE----DLGISPTEIGLLLTLFSLGYALAQPLAGRL-SDRFG----RRRVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 199 NGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTnNF 278
Cdd:pfam07690 72 FALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF-GW 150
|
170
....*....|....*...
gi 568973439 279 SYVFYMSSGFLVSGSLIL 296
Cdd:pfam07690 151 RAAFLILAILSLLAAVLL 168
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
19-295 |
3.38e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 42.15 E-value: 3.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 19 RRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLhcCVCGALLRPVatnevpepkedPLLPPKIPTRSC 98
Cdd:cd17324 120 KRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAL--LAALLLWRLL-----------PSLPPKKPGSLG 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 99 LatcVSTIRYHLAFDILRHnmgfcIYVTGVTWMNLGFALpHIFLVPYAMH-HGVDDYWAAMLMSIVGFCNIFlrpmaGLL 177
Cdd:cd17324 187 L---LSSLLLLLRNPRLRL-----AYLITFLLFGGFFAL-YTYLAPFLTDvPGFSSSAIIGLLLLFGVAGVV-----GSP 252
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 178 LAGRKSLAAYRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDR-FPSALGLFTIL 256
Cdd:cd17324 253 LAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARgLASSLYLAAYN 332
|
250 260 270
....*....|....*....|....*....|....*....
gi 568973439 257 CGVTslISPPLAGLLLDKTnNFSYVFYMSSGFLVSGSLI 295
Cdd:cd17324 333 LGGA--LGAALGGLVLDHG-GWAGVGWVGAALLLLALLL 368
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
141-295 |
3.71e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.69 E-value: 3.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 141 FLVPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGLLlAGRKSlaaYRKYLFAVAILINGLTNLICTVSADFRVLLGYCL 220
Cdd:cd17477 210 LLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWL-ADRFD---RRRVLLGCALLGALAALLLPLVPGLPLALLVLLF 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 221 V--------YSLSMCGVGilvfqvlmDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLDKTNNFSYVFYMSSGFLVSG 292
Cdd:cd17477 286 LwggaagplYTLALALAG--------DRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFL 357
|
...
gi 568973439 293 SLI 295
Cdd:cd17477 358 LFL 360
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
119-290 |
6.36e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.18 E-value: 6.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 119 MGFCIYVTGVTWMNLGFALPhiflvPYAMHHGVDDYWAAMLMSIVGFCNIFLRPMAGLLlAGRKSlaayRKYLFAVAILI 198
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLP-----ALLQSFGLSASQLGLLFALFSLGYALLQPLAGLL-ADRFG----RRPVLLLGLLL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 199 NGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMDRFPSALGLFTILCGVTSLISPPLAGLLLD-KTNN 277
Cdd:cd06174 71 FALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASsLGFG 150
|
170
....*....|...
gi 568973439 278 FSYVFYMSSGFLV 290
Cdd:cd06174 151 WRAVFLIAAALAL 163
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
18-73 |
6.76e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 37.94 E-value: 6.76e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 568973439 18 RRRPLANALASMGLSMGVTLWPLLARYLLETLGWRGAFLIFGGILLHCCVCGALLR 73
Cdd:cd17503 116 EKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLLD 171
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
8-296 |
7.16e-03 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 37.94 E-value: 7.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 8 SITVVG-LYFVRRRPLANALASMGLSMGVTLWPLLARYLLeTLGWRGAFLIFGGILLHCCVCGALLrpvatneVPEPKED 86
Cdd:cd17474 108 ALTLIGdLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAALIPVAFLAILFL-------LPEPKEK 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 87 PLLPPKIPTRSclatcvstiryhlAFDILRHNMGFCIYVTGVTWMNLGFALphIFLVPY--AMHHGVDDYWAAMLMSIVG 164
Cdd:cd17474 180 AKSSSATKLRD-------------LKKALRGRGLLTFLVSAFLYFFLYFAF--LTYLPFllELLYGISPIIIGLLFAGWS 244
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973439 165 FCNIFLRPMAGLLLAGRKSlaayRKYLFAVAILINGLTNLICTVSADFRVLLGYCLVYSLSMCGVGILVFQVLMDIVPMD 244
Cdd:cd17474 245 VLLALGSLFVGRLLKKRFG----ARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEE 320
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 568973439 245 RFPSALGLFTILCGVTSLISPPLAGLLLdKTNNFSYVFYMSSGFLVSGSLIL 296
Cdd:cd17474 321 ERGTASSLYNFVRFLGQAVGPLLFGLLL-EIFGLSAPFLVGAAIALAAAVLL 371
|
|
| |
