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Conserved domains on  [gi|568972003|ref|XP_006532456|]
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hepatitis A virus cellular receptor 1 homolog isoform X2 [Mus musculus]

Protein Classification

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List of domain hits

 Name Accession Description Interval E-value
IgV_TIM-3_like cd20982
Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3) ...
 23-127 3.41e-62

Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3), and similar domains; The members here are composed of the immunoglobulin variable (IgV) domain of T cell immunoglobulin domain and mucin domain 3 (Tim-3; also known as Hepatitis A virus cellular receptor 2 (HAVcr-2) and Cluster of Differentiation 366 (CD366)) and similar proteins. TIM-3 is a checkpoint inhibitor in immune responses to tumors, as well as involved in chronic viral infections. Thus, Tim-3 has emerged as one of most promising immune checkpoint targets for cancer immunotherapy. Tim-3 is highly expressed on Th1 lymphocytes and CD11b(+) macrophages and is upregulated on activated T and myeloid cells. TIM-3 regulates macrophage, activation and inhibits Th1 mediated immune responses to promote immunological tolerance. There are three TIM family members in humans (TIM-1, TIM-3, and TIM-4) and eight members in mice (TIM-1 to TIM-8). The IgV domain of human TIM-3 has been shown to bind ligands such as carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), high mobility group protein B1 (HMGB1)and galectin-9 (GAL9). The binding of GAL9 to TIM-3 can negatively regulate Th1 immune response, enhance immune tolerance and inhibit anti#tumor immunity. Dysregulation of the TIM-3/GAL9 pathway is implicated in numerous chronic autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus.


:

Pssm-ID: 409574  Cd Length: 107  Bit Score: 192.29  E-value: 3.41e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972003  23 VEVKGVVGHPVTLPCTYSTYRG--ITTTCWGRGQCPSSACQNTLIWTNGHRVTYQKSSRYNLKGHISEGDVSLTIENSVE 100
Cdd:cd20982    1 VEYRAEVGHNAYLPCSYTTAAPgnLVPVCWGKGACPVSYCGNVLLRTDERDVTYQKSSRYQLKGDFSKGDVSLTIENVTL 80

                         90       100
                 ....*....|....*....|....*..
gi 568972003 101 SDSGLYCCRVEIPGWFNDQKVTFSLQV 127
Cdd:cd20982   81 ADSGIYCCRIQIPGIMNDEKFNLKLVI 107
 
Name Accession Description Interval E-value
IgV_TIM-3_like cd20982
Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3) ...
 23-127 3.41e-62

Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3), and similar domains; The members here are composed of the immunoglobulin variable (IgV) domain of T cell immunoglobulin domain and mucin domain 3 (Tim-3; also known as Hepatitis A virus cellular receptor 2 (HAVcr-2) and Cluster of Differentiation 366 (CD366)) and similar proteins. TIM-3 is a checkpoint inhibitor in immune responses to tumors, as well as involved in chronic viral infections. Thus, Tim-3 has emerged as one of most promising immune checkpoint targets for cancer immunotherapy. Tim-3 is highly expressed on Th1 lymphocytes and CD11b(+) macrophages and is upregulated on activated T and myeloid cells. TIM-3 regulates macrophage, activation and inhibits Th1 mediated immune responses to promote immunological tolerance. There are three TIM family members in humans (TIM-1, TIM-3, and TIM-4) and eight members in mice (TIM-1 to TIM-8). The IgV domain of human TIM-3 has been shown to bind ligands such as carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), high mobility group protein B1 (HMGB1)and galectin-9 (GAL9). The binding of GAL9 to TIM-3 can negatively regulate Th1 immune response, enhance immune tolerance and inhibit anti#tumor immunity. Dysregulation of the TIM-3/GAL9 pathway is implicated in numerous chronic autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus.


Pssm-ID: 409574  Cd Length: 107  Bit Score: 192.29  E-value: 3.41e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972003  23 VEVKGVVGHPVTLPCTYSTYRG--ITTTCWGRGQCPSSACQNTLIWTNGHRVTYQKSSRYNLKGHISEGDVSLTIENSVE 100
Cdd:cd20982    1 VEYRAEVGHNAYLPCSYTTAAPgnLVPVCWGKGACPVSYCGNVLLRTDERDVTYQKSSRYQLKGDFSKGDVSLTIENVTL 80

                         90       100
                 ....*....|....*....|....*..
gi 568972003 101 SDSGLYCCRVEIPGWFNDQKVTFSLQV 127
Cdd:cd20982   81 ADSGIYCCRIQIPGIMNDEKFNLKLVI 107
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-122 1.06e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 63.25  E-value: 1.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972003   24 EVKGVVGHPVTLPCTYSTYR--GITTTCWGRGQcPSSACQNTLIWTNGHRVTYQKSSRYNLKGHISEGDVSLTIENSVES 101
Cdd:pfam07686   5 EVTVALGGSVTLPCTYSSSMseASTSVYWYRQP-PGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTLS 83

                          90       100
                  ....*....|....*....|.
gi 568972003  102 DSGLYCCRVEIPGWFNDQKVT 122
Cdd:pfam07686  84 DSGTYTCAVIPSGEGVFGKGT 104
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 25-127 1.49e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.80  E-value: 1.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972003    25 VKGVVGHPVTLPCTYSTYRGITTTcwgrgqcpssacqntliWTNGHRVTYQKSSRYNLKGhiSEGDVSLTIENSVESDSG 104
Cdd:smart00410   4 VTVKEGESVTLSCEASGSPPPEVT-----------------WYKQGGKLLAESGRFSVSR--SGSTSTLTISNVTPEDSG 64

                           90       100
                   ....*....|....*....|...
gi 568972003   105 LYCCRVEIPGwfNDQKVTFSLQV 127
Cdd:smart00410  65 TYTCAATNSS--GSASSGTTLTV 85
 
Name Accession Description Interval E-value
IgV_TIM-3_like cd20982
Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3) ...
 23-127 3.41e-62

Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3), and similar domains; The members here are composed of the immunoglobulin variable (IgV) domain of T cell immunoglobulin domain and mucin domain 3 (Tim-3; also known as Hepatitis A virus cellular receptor 2 (HAVcr-2) and Cluster of Differentiation 366 (CD366)) and similar proteins. TIM-3 is a checkpoint inhibitor in immune responses to tumors, as well as involved in chronic viral infections. Thus, Tim-3 has emerged as one of most promising immune checkpoint targets for cancer immunotherapy. Tim-3 is highly expressed on Th1 lymphocytes and CD11b(+) macrophages and is upregulated on activated T and myeloid cells. TIM-3 regulates macrophage, activation and inhibits Th1 mediated immune responses to promote immunological tolerance. There are three TIM family members in humans (TIM-1, TIM-3, and TIM-4) and eight members in mice (TIM-1 to TIM-8). The IgV domain of human TIM-3 has been shown to bind ligands such as carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), high mobility group protein B1 (HMGB1)and galectin-9 (GAL9). The binding of GAL9 to TIM-3 can negatively regulate Th1 immune response, enhance immune tolerance and inhibit anti#tumor immunity. Dysregulation of the TIM-3/GAL9 pathway is implicated in numerous chronic autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus.


Pssm-ID: 409574  Cd Length: 107  Bit Score: 192.29  E-value: 3.41e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972003  23 VEVKGVVGHPVTLPCTYSTYRG--ITTTCWGRGQCPSSACQNTLIWTNGHRVTYQKSSRYNLKGHISEGDVSLTIENSVE 100
Cdd:cd20982    1 VEYRAEVGHNAYLPCSYTTAAPgnLVPVCWGKGACPVSYCGNVLLRTDERDVTYQKSSRYQLKGDFSKGDVSLTIENVTL 80

                         90       100
                 ....*....|....*....|....*..
gi 568972003 101 SDSGLYCCRVEIPGWFNDQKVTFSLQV 127
Cdd:cd20982   81 ADSGIYCCRIQIPGIMNDEKFNLKLVI 107
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 24-122 1.06e-12

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 63.25  E-value: 1.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972003   24 EVKGVVGHPVTLPCTYSTYR--GITTTCWGRGQcPSSACQNTLIWTNGHRVTYQKSSRYNLKGHISEGDVSLTIENSVES 101
Cdd:pfam07686   5 EVTVALGGSVTLPCTYSSSMseASTSVYWYRQP-PGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTLS 83

                          90       100
                  ....*....|....*....|.
gi 568972003  102 DSGLYCCRVEIPGWFNDQKVT 122
Cdd:pfam07686  84 DSGTYTCAVIPSGEGVFGKGT 104
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 29-128 1.08e-06

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 46.49  E-value: 1.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972003  29 VGHPVTLPCTYSTyRGITTTCWGRgQCPSSACQntLIWTNGHRVTYQKSSRYNLKGHISEGDVSLTIENSVESDSGLYCC 108
Cdd:cd04983   12 EGENVTLNCNYST-STFYYLFWYR-QYPGQGPQ--FLIYISSDSGNKKKGRFSATLDKSRKSSSLHISAAQLSDSAVYFC 87

                         90       100
                 ....*....|....*....|....
gi 568972003 109 RVeiPGWFNDQKVTF----SLQVK 128
Cdd:cd04983   88 AL--SESGGTGKLTFgkgtRLTVE 109
Ig_SLAM-like_N cd16842
N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule ...
 24-127 6.87e-05

N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the signaling lymphocyte activation molecule (SLAM) family and similar proteins. The SLAM family is a group of immune-cell specific receptors that can regulate both adaptive and innate immune responses. Members of this group include proteins such as CD84, SLAM (CD150), Ly-9 (CD229), NTB-A (ly-108, SLAM6), 19A (CRACC), and SLAMF9. The genes coding for the SLAM family are nested on chromosome 1, in humans at 1q23, and in mice at 1H2. The SLAM family is a subset of the CD2 family, which also includes CD2 and CD58 located on chromosome 1 at 1p13 in humans. In mice, CD2 is located on chromosome 3, and there is no CD58 homolog. The SLAM family proteins are organized as an extracellular domain with either two or four Ig-like domains, a single transmembrane segment, and a cytoplasmic region having Tyr-based motifs. The extracellular domain is organized as a membrane-distal Ig variable (IgV) domain that is responsible for ligand recognition and a membrane-proximal truncated Ig constant-2 (IgC2) domain.


Pssm-ID: 409517  Cd Length: 102  Bit Score: 41.15  E-value: 6.87e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972003  24 EVKGVVGHPVTLPCTYSTYRGITTTCWGRGQ-----CPSSACQNTLIWTNghrvtyqksSRYNLKGHISEGDVSLTIENS 98
Cdd:cd16842    2 EVNGILGGSVTFPLNISDGQEIENITWSFKTslaviAPGEGGAPEIIITD---------KSYKERLNISQNDYSLQISNL 72

                         90       100
                 ....*....|....*....|....*....
gi 568972003  99 VESDSGLYCCRVEIPGWFNDQKVTFSLQV 127
Cdd:cd16842   73 TMEDAGSYRARINTKNSRVTITKEFTLHI 101
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 29-123 1.14e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 40.78  E-value: 1.14e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972003  29 VGHPVTLPCTYSTYRGITTTCWGRGQcPSSACQNTLIWTNGHRVTYQK-SSRYNLKGhISEGDVSLTIENSVESDSGLYC 107
Cdd:cd00099   12 EGESVTLSCEVSSSFSSTYIYWYRQK-PGQGPEFLIYLSSSKGKTKGGvPGRFSGSR-DGTSSFSLTISNLQPEDSGTYY 89

                         90
                 ....*....|....*.
gi 568972003 108 CRVEipGWFNDQKVTF 123
Cdd:cd00099   90 CAVS--ESGGTDKLTF 103
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 25-127 1.49e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.80  E-value: 1.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972003    25 VKGVVGHPVTLPCTYSTYRGITTTcwgrgqcpssacqntliWTNGHRVTYQKSSRYNLKGhiSEGDVSLTIENSVESDSG 104
Cdd:smart00410   4 VTVKEGESVTLSCEASGSPPPEVT-----------------WYKQGGKLLAESGRFSVSR--SGSTSTLTISNVTPEDSG 64

                           90       100
                   ....*....|....*....|...
gi 568972003   105 LYCCRVEIPGwfNDQKVTFSLQV 127
Cdd:smart00410  65 TYTCAATNSS--GSASSGTTLTV 85
IGv smart00406
Immunoglobulin V-Type;
33-108 2.45e-04

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 38.90  E-value: 2.45e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568972003    33 VTLPCTYSTYRGITTTC-WGRgQCPSSACQNTLIWTNGHRVTYQKS--SRYNLKGHISEGDVSLTIENSVESDSGLYCC 108
Cdd:smart00406   2 VTLSCKFSGSTFSSYYVsWVR-QPPGKGLEWLGYIGSNGSSYYQESykGRFTISKDTSKNDVSLTISNLRVEDTGTYYC 79
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 24-110 4.65e-04

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 38.97  E-value: 4.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972003  24 EVKGVVGHPVTLPCTYSTYRGITTTC---WGrgQCPSSACQNTLIWTNGHRV----TYQKSSRYNLKGHISEGDVSLTIE 96
Cdd:cd20960    9 EIKKVAGENVTLPCHHQLGLEDQGTLdieWL--LLPSDKVEKVVITYSGDRVynhyYPALKGRVAFTSNDLSGDASLNIS 86

                         90
                 ....*....|....
gi 568972003  97 NSVESDSGLYCCRV 110
Cdd:cd20960   87 NLKLSDTGTYQCKV 100
IgV_NKp30 cd20926
Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and ...
 24-114 6.64e-04

Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and similar domains; The members here are composed of the immunoglobulin variable region (IgV) of Natural Killer cell activating receptor NKp30 (also known as Natural Cytotoxicity triggering Receptor 3 (NCR3)) and similar domains. NKp30 Recognizes the N-Terminal IgV Domain of B7-H6. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells.


Pssm-ID: 409520  Cd Length: 112  Bit Score: 38.80  E-value: 6.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972003  24 EVKGVVGHPVTLPCTYSTYRG---ITTTCWGRGQ-CPSSACQNTLIWTNGhRVTYQKSSRYnLKGHISEgdvsLTIENSV 99
Cdd:cd20926    9 EIRTLEGSSAFLPCSFNASQGrlaIGSVTWFRDEvAPGKEVRNGTPEFRG-RLAPLASSRF-LRDHQAE----LHIWDVR 82

                         90
                 ....*....|....*
gi 568972003 100 ESDSGLYCCRVEIPG 114
Cdd:cd20926   83 GHDAGIYVCRVEVLG 97
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 24-129 2.45e-03

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 37.11  E-value: 2.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972003  24 EVKGVVGHPVTLPCTYSTYRGITTTCWGRgQCPSSacQNTLIWTNGHRVTYQKSSRYNLKGHISEGDVSLTIENSVESDS 103
Cdd:cd07706    8 DVSVQVGEEVTLNCRYETSWTNYYLFWYK-QLPSG--EMTFLIRQDSSEQNAKSGRYSVNFQKAQKSISLTISALQLEDS 84

                         90       100       110
                 ....*....|....*....|....*....|
gi 568972003 104 GLYCCRVEIPGwfNDQKVTFS----LQVKP 129
Cdd:cd07706   85 AKYFCALSLPY--DTDKLIFGkgtrLTVEP 112
Ig_CSPGs_LP_like cd05714
Immunoglobulin (Ig)-like domain of chondroitin sulfate proteoglycans (CSPGs), human cartilage ...
 25-127 3.20e-03

Immunoglobulin (Ig)-like domain of chondroitin sulfate proteoglycans (CSPGs), human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in chondroitin sulfate proteoglycans (CSPGs) and human cartilage link protein (LP). Included in this group are the CSPGs aggrecan, versican, and neurocan. In CSPGs, this Ig-like domain is followed by hyaluronan (HA)-binding tandem repeats, and a C-terminal region with epidermal growth factor-like, lectin-like, and complement regulatory protein-like domains. Separating these N- and C-terminal regions is a nonhomologous glycosaminoglycan attachment region. In cartilage, aggrecan forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggrecan and versican have a wide distribution in connective tissue and extracellular matrices. Neurocan is localized almost exclusively in nervous tissue. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. There is considerable evidence that HA-binding CSPGs are involved in developmental processes in the central nervous system. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409379  Cd Length: 123  Bit Score: 36.80  E-value: 3.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568972003  25 VKGVVGHPVTLPCTYST---------------YRGITTTCWGRGQCPSSACQNTLIWtngHRVTYQKSSRYNLKGHiSEG 89
Cdd:cd05714    7 VFSHLGGNVTLPCKFYRdptafgsgihkirikWTKLTSDSGYLKEVDVLVAMGNVVY---HKKTYGGRVSVPLKPG-SDS 82

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568972003  90 DVSLTIENSVESDSGLYCCRVeIPGwFNDQKVTFSLQV 127
Cdd:cd05714   83 DASLVITDLTASDYGLYRCEV-IEG-IEDDQDVVALDV 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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